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Receptor
PDB id Resolution Class Description Source Keywords
5C1M 2.1 Å NON-ENZYME: SIGNAL_HORMONE CRYSTAL STRUCTURE OF ACTIVE MU-OPIOID RECEPTOR BOUND TO THE BU72 MUS MUSCULUS LIGANDS MICE AGONISTS MORPHINANS ACTIVATION RECEPTORS MU NANOBODY SIGNALING PROTEIN-ANTAGONIST COMPLEX
Ref.: STRUCTURAL INSIGHTS INTO MU-OPIOID RECEPTOR ACTIVAT NATURE V. 524 315 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
4VO A:401;
Valid;
none;
Ki = 21 pM
428.566 C28 H32 N2 O2 C[C@@...
PO4 A:405;
Invalid;
none;
submit data
94.971 O4 P [O-]P...
P6G A:407;
A:406;
Invalid;
Invalid;
none;
none;
submit data
282.331 C12 H26 O7 C(COC...
CLR A:404;
Valid;
none;
submit data
386.654 C27 H46 O CC(C)...
OLC A:403;
A:402;
Valid;
Valid;
Atoms found LESS than expected: % Diff = 0;
Atoms found LESS than expected: % Diff = 0;
submit data
356.54 C21 H40 O4 CCCCC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5C1M 2.1 Å NON-ENZYME: SIGNAL_HORMONE CRYSTAL STRUCTURE OF ACTIVE MU-OPIOID RECEPTOR BOUND TO THE BU72 MUS MUSCULUS LIGANDS MICE AGONISTS MORPHINANS ACTIVATION RECEPTORS MU NANOBODY SIGNALING PROTEIN-ANTAGONIST COMPLEX
Ref.: STRUCTURAL INSIGHTS INTO MU-OPIOID RECEPTOR ACTIVAT NATURE V. 524 315 2015
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 286 families.
1 5C1M Ki = 21 pM 4VO C28 H32 N2 O2 C[C@@]12C[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 5C1M Ki = 21 pM 4VO C28 H32 N2 O2 C[C@@]12C[....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 5C1M Ki = 21 pM 4VO C28 H32 N2 O2 C[C@@]12C[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 4VO; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 4VO 1 1
Ligand no: 2; Ligand: CLR; Similar ligands found: 18
No: Ligand ECFP6 Tc MDL keys Tc
1 CLR 1 1
2 HC3 0.807692 0.921053
3 HC9 0.666667 0.894737
4 Y01 0.638298 0.853659
5 HC2 0.58427 0.921053
6 HCD 0.58427 0.921053
7 5JK 0.573034 0.921053
8 HCR 0.573034 0.921053
9 2OB 0.560748 0.8
10 2DC 0.543478 0.829268
11 CLL 0.535714 0.8
12 PLO 0.529412 0.864865
13 K2B 0.494624 0.861111
14 XCA 0.46 0.829268
15 AND 0.44186 0.864865
16 0T9 0.432692 0.825
17 L39 0.428571 0.785714
18 DL4 0.407767 0.804878
Ligand no: 3; Ligand: OLC; Similar ligands found: 71
No: Ligand ECFP6 Tc MDL keys Tc
1 OLC 1 1
2 OLB 1 1
3 MVC 0.958333 1
4 78N 0.9375 1
5 78M 0.9375 1
6 1QW 0.808511 0.969697
7 GYM 0.808511 0.969697
8 NKP 0.683333 0.688889
9 1AG 0.62069 1
10 D3D 0.597222 0.733333
11 PGW 0.597222 0.733333
12 PGV 0.589041 0.733333
13 DR9 0.589041 0.733333
14 P6L 0.581081 0.733333
15 S12 0.577465 0.627451
16 OZ2 0.573333 0.733333
17 PGM 0.571429 0.727273
18 D21 0.558824 0.652174
19 P3A 0.558442 0.733333
20 NKN 0.533333 0.666667
21 NKO 0.533333 0.666667
22 DGA 0.525424 0.828571
23 L2C 0.525424 0.828571
24 DDR 0.525424 0.828571
25 FAW 0.525424 0.828571
26 ELA 0.519231 0.617647
27 NER 0.519231 0.617647
28 OLA 0.519231 0.617647
29 LOP 0.5 0.603774
30 L9Q 0.5 0.603774
31 6OU 0.5 0.603774
32 VCA 0.490566 0.617647
33 PAM 0.490566 0.617647
34 ZPE 0.487179 0.603774
35 MPG 0.483871 0.941176
36 TGL 0.482759 0.722222
37 PGT 0.472222 0.711111
38 LHG 0.472222 0.711111
39 1O2 0.46988 0.711111
40 LBR 0.469697 0.805556
41 B7N 0.469136 0.607843
42 PVC 0.46875 0.815789
43 3TF 0.464286 0.711111
44 RCL 0.453125 0.705882
45 G2A 0.446429 0.882353
46 2JT 0.446429 0.882353
47 GP7 0.435294 0.603774
48 2WA 0.432836 0.885714
49 2WM 0.432836 0.885714
50 3WM 0.432836 0.885714
51 1L2 0.428571 0.711111
52 PGK 0.426829 0.666667
53 LPP 0.426471 0.630435
54 3PH 0.426471 0.630435
55 6PH 0.426471 0.630435
56 F57 0.426471 0.630435
57 7PH 0.426471 0.630435
58 AGA 0.421053 0.711111
59 PX8 0.42029 0.608696
60 PX2 0.42029 0.608696
61 7P9 0.42029 0.630435
62 18C 0.41791 0.608696
63 16C 0.41791 0.608696
64 SPL 0.41791 0.608696
65 PEK 0.411765 0.603774
66 VA 0.40678 0.617647
67 GGD 0.40625 0.680851
68 8ND 0.405797 0.636364
69 CD4 0.405405 0.666667
70 CDL 0.4 0.622222
71 EIC 0.4 0.647059
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5C1M; Ligand: 4VO; Similar sites found with APoc: 138
This union binding pocket(no: 1) in the query (biounit: 5c1m.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
1 1UO5 PIH None
2 5NNT DPV None
3 5CSD ACD None
4 5K53 STE 0.763359
5 6CB2 OLC 1.02389
6 5DLY 5D7 2.4
7 5X3R 7Y3 2.43902
8 1R6N 434 2.8436
9 3KXC PLM 3.2
10 4POJ 2VP 3.2
11 5UWA 8ND 3.2
12 1YMT DR9 3.25203
13 4QJR PIZ 3.26531
14 5FQK 6NT 3.34572
15 3D78 NBB 3.36134
16 2W3L DRO 3.47222
17 6AYH C3G 3.48259
18 3KPX CZH 3.53535
19 2VQ5 HBA 4
20 1HG4 LPP 4
21 2HZL PYR 4
22 3I51 6PL 4
23 5HCV 60R 4
24 3TL1 JRO 4
25 3EWC MCF 4.05405
26 2ZRU FMN 4.39189
27 5XJD 87L 4.54545
28 1EWF PC1 4.72973
29 3EKK GS2 4.8
30 1DB1 VDX 4.8
31 6B2M COA 4.8
32 1G2N EPH 4.8
33 5NXX 3Q7 4.8
34 3C3N FMN 4.8
35 3KO0 TFP 4.9505
36 3KDU NKS 5.05415
37 1PZL MYR 5.06329
38 5A1S FLC 5.06757
39 3GST GPR 5.06757
40 3FS1 MYR 5.21739
41 6CGN DA 5.40541
42 2YB9 HA0 5.40541
43 3R1V AZB 5.51181
44 3F8C HT1 5.55556
45 3I0O SMI 5.6
46 2I0G I0G 5.6
47 1XX4 BAM 5.6
48 3E8T UQ8 5.6
49 4GU5 FAD 5.6
50 4K7O EKZ 5.6
51 5M36 9SZ 5.67686
52 1DNP FAD 6.08108
53 1NP7 FAD 6.08108
54 2D5X L35 6.16438
55 5MWE TCE 6.17284
56 1KYZ FER 6.4
57 1QNF FAD 6.4
58 1QNF HDF 6.4
59 3EWK FAD 6.4
60 2X5W K2B 6.4
61 3E7S AT2 6.4
62 1LN1 DLP 6.4
63 5W7B MYR 6.4
64 2UXI G50 6.4
65 2OBD PCW 6.41892
66 3OKI OKI 6.43777
67 2OCI TYC 6.69291
68 1LRI CLR 7.14286
69 3AQT RCO 7.2
70 4DOL PLM 7.2
71 5GUE GGS 7.2
72 3O01 DXC 8
73 3B9Z CO2 8
74 6C7D EOJ 8
75 2QE4 JJ3 8
76 2BJ4 OHT 8
77 4NKW PLO 8
78 3ZQE DXC 8
79 2AIB ERG 8.16327
80 4N02 FNR 8.8
81 5OLK DTP 8.8
82 2WOR 2AN 9
83 1NU4 MLA 9.27835
84 1ZOY UQ1 9.45946
85 2Z7I 742 9.45946
86 3CH6 311 9.6
87 3CH6 NAP 9.6
88 4I90 CHT 9.6
89 5LUN OGA 9.6
90 5LUN ARG 9.6
91 1XZ3 ICF 9.77011
92 2WCJ M21 9.92908
93 3KP6 SAL 9.93377
94 2Y69 CHD 10
95 5CHR 4NC 10.219
96 6AYI C3G 10.4
97 3LN0 52B 10.8108
98 1GUX ASP LEU TYR CYS TYR GLU GLN LEU ASN 11.0092
99 5C9J STE 11.1111
100 5C9J DAO 11.1111
101 4GBD MCF 11.2
102 3L9R L9Q 11.2
103 2XXP DSL 11.2
104 1ZPD CIT 12
105 4PGK Y69 12.7049
106 4F7E 0SH 12.8
107 1N1G BCP 12.8
108 2ALG DAO 13.0435
109 2ALG HP6 13.0435
110 5TO8 7FM 13.6
111 1YOK P6L 14.4
112 4WAS NAP 14.4
113 4LY9 1YY 14.4
114 4LY9 S6P 14.4
115 2GWH PCI 15.2
116 4MRP GSH 15.2
117 5Z84 CHD 15.2174
118 5Z84 PGV 15.2174
119 5ZCO CHD 15.2174
120 5W97 CHD 15.2174
121 2DYS PGV 15.2174
122 2DYR PGV 15.2174
123 5ZCO PGV 15.2174
124 3AJM 4IP 16
125 6GG9 FMN 16
126 4V1F BQ1 16.2791
127 5N18 8HZ 18.3486
128 4RJD TFP 19.697
129 5V4R MGT 19.7531
130 2E2R 2OH 20.8
131 5DRB 5FJ 22.4
132 5AM1 I5T 28.8
133 4X8D AVI 29.6
134 1ZED PNP 33.6
135 2RH1 CAU 34.1216
136 3HUJ AGH 36.8
137 4OGQ 7PH 41.9355
138 3RUG DB6 44.8
Pocket No.: 2; Query (leader) PDB : 5C1M; Ligand: OLC; Similar sites found with APoc: 3
This union binding pocket(no: 2) in the query (biounit: 5c1m.bio1) has 6 residues
No: Leader PDB Ligand Sequence Similarity
1 4O1Z MXM 8.8
2 3LN0 52B 10.8108
3 3P9C SAH 13.6
Pocket No.: 3; Query (leader) PDB : 5C1M; Ligand: OLC; Similar sites found with APoc: 780
This union binding pocket(no: 3) in the query (biounit: 5c1m.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 1G27 BB1 None
2 6CHP F0Y None
3 1BWO LPC None
4 2IYG FMN None
5 3ND6 ATP None
6 1DTL BEP None
7 5CSD ACD None
8 1ECM TSA None
9 3QMN COA None
10 1YRX FMN None
11 3RV5 DXC None
12 3RET PYR None
13 3RET SAL None
14 1L6O SER LEU LYS LEU MET THR THR VAL None
15 1UO5 PIH None
16 2ZFZ ARG None
17 4XRQ 1B0 0.4329
18 5K53 STE 0.763359
19 6CB2 OLC 1.02389
20 5DUF G7A 1.6
21 6ET8 BWH 1.6
22 1JAY F42 1.68919
23 4OMJ 2TX 1.68919
24 4MNS 2AX 1.88679
25 1PZX PLM 2.07612
26 3P9T TCL 2.28311
27 4C2X NHW 2.36486
28 4E70 N7I 2.36486
29 5N87 N66 2.36486
30 5TWB FAD 2.36486
31 1IYK MYA 2.4
32 2XSU PIE 2.4
33 4ORM FMN 2.4
34 4ORM ORO 2.4
35 4ORM 2V6 2.4
36 1TV5 N8E 2.4
37 5K7H IVC 2.4
38 2HJ3 FAD 2.4
39 3CAQ NDP 2.4
40 5X3R 7Y3 2.43902
41 2GBB CIT 2.5641
42 1Q1Y BB2 2.6178
43 1ID0 ANP 2.63158
44 3IIS PID 2.64901
45 4WPF 3SN 2.65152
46 5NWI TYR PHE SER SEP ASN 2.67176
47 4U8P FDA 2.7027
48 4U8P UDP 2.7027
49 3G4Q MCH 2.73973
50 5B4B LP5 2.82258
51 1R6N 434 2.8436
52 3EM0 CHD 2.89855
53 3AGC RCC 2.89855
54 2FR3 REA 2.91971
55 2GSQ GBI 2.9703
56 5LJ0 6XX 3.07692
57 5IJJ I6P 3.125
58 5NI5 8YB 3.125
59 5AZC PGT 3.2
60 3SHZ 5CO 3.2
61 3TGE TGE 3.2
62 5UWA 8ND 3.2
63 6MPT C30 3.2
64 2Q8G AZX 3.2
65 2OZ5 7XY 3.2
66 4POJ 2VP 3.2
67 5K7K 6RJ 3.2
68 4M8E 29V 3.2
69 2FP2 TSA 3.2
70 2E3N 6CM 3.2
71 1P72 ADP 3.2
72 3KXC PLM 3.2
73 3BQD DAY 3.2
74 3NTA COA 3.2
75 1A05 IPM 3.2
76 2HPS CTZ 3.22581
77 1U1B PAX 3.22581
78 4O4Z N2O 3.24675
79 1YMT DR9 3.25203
80 4QJR PIZ 3.26531
81 1ZDT PEF 3.3195
82 1YP0 PEF 3.34728
83 2X32 OTP 3.35196
84 3D78 NBB 3.36134
85 6BR9 PGV 3.37838
86 4NB5 2JT 3.37838
87 6BR9 6OU 3.37838
88 4WGF HX2 3.41463
89 6AYH C3G 3.48259
90 3KPX CZH 3.53535
91 6BR8 6OU 3.57143
92 6BR8 PGV 3.57143
93 4E1N TQX 3.61446
94 5MTE BB2 3.64964
95 1J78 VDY 3.71622
96 5Y02 HBX 3.73832
97 4EKQ NPO 3.74332
98 4NAT 2W5 3.75
99 4NAT ADP 3.75
100 4BVM VCA 3.7594
101 1M48 FRG 3.7594
102 3ET3 ET1 3.76712
103 6AD9 KK4 3.83275
104 4H07 IPH 3.8961
105 2HFP NSI 3.90071
106 3T50 FMN 3.90625
107 2O5L MNR 3.92157
108 1GHE ACO 3.9548
109 2P4Y C03 3.97112
110 1FP1 HCC 4
111 3I51 6PL 4
112 3V66 D3A 4
113 1M13 HYF 4
114 5B25 4QJ 4
115 2C43 COA 4
116 1P1M MET 4
117 4B5P ACO 4
118 5OSW DIU 4
119 1EM6 CP4 4
120 3EE4 MYR 4
121 5A86 D7E 4
122 4KP7 1UQ 4
123 2A3I C0R 4
124 2C3Q GTX 4
125 2YOO K2B 4
126 2EV1 OLA 4
127 3NHT U46 4
128 5EEH P9P 4
129 1HG4 LPP 4
130 4JE7 BB2 4
131 5IKH 6BW 4
132 5HCV 60R 4
133 2BIF BOG 4
134 1LOX RS7 4
135 1FM9 9CR 4.04412
136 3H0A D30 4.04412
137 4G8R 96P 4.05405
138 5IKR ID8 4.05405
139 3Q8G PEE 4.0625
140 1XW6 GSH 4.12844
141 4OAS 2SW 4.16667
142 4DR9 BB2 4.16667
143 3VHZ SOG 4.19847
144 3VHZ L2P GLC MAN SGA 4.19847
145 4XU6 TDA 4.28571
146 5EP2 AZU 4.29688
147 4WN5 MVC 4.34783
148 1FP2 HMO 4.39189
149 6H21 UD1 4.39189
150 5WX3 COA 4.39189
151 5C2H 4PX 4.39189
152 3TIK JKF 4.39189
153 1N5S ADL 4.46429
154 2QM9 TDZ 4.51613
155 5BVS EIC 4.54545
156 2NNQ T4B 4.58015
157 3SFI 3SF 4.66102
158 1RV1 IMZ 4.70588
159 5G3N X28 4.72441
160 3GFZ FMN 4.72973
161 6F6E PLM 4.72973
162 4L1F COS 4.72973
163 1EWF PC1 4.72973
164 5X13 HC4 4.78723
165 6BA2 7KM 4.8
166 4DOO DAO 4.8
167 4BNU 9KQ 4.8
168 4ZBR DIF 4.8
169 4ZBR NPS 4.8
170 2HU5 GLY PHE 4.8
171 3UR0 SVR 4.8
172 2OKL BB2 4.8
173 1TMX HGX 4.8
174 5V13 JH3 4.8
175 1XRO LEU 4.8
176 4V3I ASP LEU THR ARG PRO 4.8
177 5FUS DAO 4.8
178 6B2M COA 4.8
179 3V78 ET 4.8
180 4QGE 35O 4.8
181 2C31 TZD 4.8
182 2C31 ADP 4.8
183 4WVO 3UZ 4.8
184 2YAY DUP 4.8
185 1UOU CMU 4.8
186 1UDY FAD 4.8
187 1UDY CS8 4.8
188 4PYW ACE THR THR ALA ILE NH2 4.8
189 5JFL NAD 4.8
190 2Y31 SMQ 4.8
191 6AP8 BNY 4.8
192 2BHW NEX 4.8
193 1RQJ RIS 4.8
194 4PJT 2YQ 4.8
195 3W68 VIV 4.8
196 6D5G FVD 4.8
197 5KLP IHP 4.8
198 6D55 FWA 4.8
199 6AP6 TLF 4.83271
200 5F5N 5VD 4.84429
201 1K7L 544 4.86111
202 4V2O CLQ 4.87805
203 1LQY BB2 4.8913
204 5VWK PRO ALA TRP ASP GLU THR ASN LEU 4.91803
205 3KO0 TFP 4.9505
206 4HBM 0Y7 5
207 3L41 LYS PRO SEP GLN GLU LEU 5
208 3KDU NKS 5.05415
209 1PZL MYR 5.06329
210 3NT6 COA 5.06757
211 4J7Q B7N 5.06757
212 3NTD COA 5.06757
213 5U83 ZN8 5.18868
214 3UWB BB2 5.19481
215 3FS1 ALA ALA LEU ALA ALA LEU LEU ALA ALA 5.21739
216 3FS1 MYR 5.21739
217 3WBG 2AN 5.22876
218 3FEI CTM 5.24345
219 5B0I BOG 5.24781
220 1MDC PLM 5.30303
221 1RL4 BL5 5.31915
222 4IS0 1R4 5.39419
223 3R9C ECL 5.40541
224 2YB9 HA0 5.40541
225 4OKZ 3E9 5.40541
226 4FC7 COA 5.41516
227 4FC7 NAP 5.41516
228 4WUJ FMN 5.44218
229 1MID LAP 5.49451
230 3R1V AZB 5.51181
231 1S17 GNR 5.55556
232 5MU6 MYA 5.6
233 5MU6 KFK 5.6
234 2I0G I0G 5.6
235 5F1R 42O 5.6
236 3E8T UQ8 5.6
237 1U3R 338 5.6
238 5G57 6M5 5.6
239 5CFT APC 5.6
240 5CFT 51G 5.6
241 3D9F N6C 5.6
242 3D9F FAD 5.6
243 3E3U NVC 5.6
244 4O4K 2PK 5.6
245 4DSG UDP 5.6
246 4DSG FAD 5.6
247 3ROE THM 5.6
248 1YYE 196 5.6
249 3RO7 TDR 5.6
250 3U3U EAH 5.6
251 3HP9 CF1 5.6
252 4KVL PLM 5.6
253 2WPF WPF 5.6
254 1TW4 CHD 5.6
255 2C0U FAD NBT 5.6
256 4GFD 0YB 5.6
257 1PZO CBT 5.6
258 2XFH CL6 5.6
259 5EY0 GTP 5.6
260 3LCV SAM 5.6
261 4LPG 1MV 5.6
262 1R5L VIV 5.6
263 3I59 N6R 5.6
264 3F5K CE5 5.6
265 4OHU NAD 5.6
266 5UC4 83S 5.6
267 5J6A P46 5.6
268 4OB6 S2T 5.6
269 4OHU 2TK 5.6
270 2YI0 YI0 5.6
271 3RS8 APR 5.6
272 5WRI A3P 5.6
273 3RS8 ALA TRP LEU PHE GLU ALA 5.6
274 1YC4 43P 5.6
275 3GB5 FMN 5.6
276 4GU5 FAD 5.6
277 3CB2 GDP 5.6
278 4WT2 3UD 5.71429
279 4OGN 2U5 5.71429
280 6FTB M0E 5.71429
281 4I4B 1CV 5.74324
282 3HYW DCQ 5.74324
283 1NF8 BOG 5.7971
284 5HZ9 5M8 5.92593
285 6BTN E8M 5.94059
286 6BTQ E8S 5.94059
287 1NP7 FAD 6.08108
288 5HCN DAO 6.13027
289 2WG9 OCA 6.15385
290 5MWE TCE 6.17284
291 1N8V BDD 6.25
292 2HW2 RFP 6.29371
293 2YLD CMO 6.29921
294 3BEJ MUF 6.30252
295 3DCT 064 6.38298
296 4UWJ MYA 6.4
297 4UWJ 7L5 6.4
298 2WSA 646 6.4
299 2WSA MYA 6.4
300 1QV1 CZH 6.4
301 5W7B MYR 6.4
302 2C78 PUL 6.4
303 2HKJ RDC 6.4
304 2X5W K2B 6.4
305 4CVZ TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 6.4
306 6F70 GSH 6.4
307 4RPL FAD 6.4
308 4RPL 3UC 6.4
309 5LPA 71R 6.4
310 5LPA ATP 6.4
311 3WYJ H78 6.4
312 2UXI G50 6.4
313 2X24 X24 6.4
314 4RHP PEF 6.4
315 3QKD HI0 6.4
316 2QO4 CHD 6.4
317 4RC8 STE 6.4
318 1OWB NAD 6.4
319 2OBF F83 6.4
320 3W54 RNB 6.4
321 1LN1 DLP 6.4
322 3EWK FAD 6.4
323 5YZC 95C 6.4
324 6D6L FY4 6.4
325 4C9G CXT 6.4
326 2YFB SIN 6.4
327 5W7B PA1 PO4 FTT FTT GCS FTT PO4 KDO MYR 6.4
328 3QCP FAD 6.4
329 5VZ0 2BA 6.4
330 4DXJ 0M9 6.4
331 2D3M COA 6.4
332 3G5K BB2 6.4
333 2F99 AKV 6.4
334 2OBD PCW 6.41892
335 2OBD 2OB 6.41892
336 6BMM OLB 6.41892
337 6ARJ SAH 6.41892
338 3OKI OKI 6.43777
339 1P1C SAH 6.53266
340 5Z1N PEF 6.54762
341 5ICK FEZ 6.55022
342 4OIV XX9 6.63717
343 4DS8 A8S 6.69856
344 3SE5 ANP 6.70732
345 3JRS A8S 6.73077
346 1AUA BOG 6.75676
347 3AHO 3A2 6.75676
348 2ISJ FMN 6.75676
349 4Q0P 0MK 6.92308
350 3KDJ A8S 6.93069
351 4IBF 1D5 6.97674
352 3GWN FAD 7.01754
353 3G5N PB2 7.09459
354 2J8C U10 7.11744
355 2J8C SPO 7.11744
356 3ZUY TCH 7.12074
357 5N26 CPT 7.14286
358 2ZCQ B65 7.16724
359 1IID NHM 7.2
360 6B21 C9V 7.2
361 3FZG SAM 7.2
362 1XMU ROF 7.2
363 1DMH LIO 7.2
364 1UBY DMA 7.2
365 5OHJ 9VE 7.2
366 1XMY ROL 7.2
367 1W2Y DUN 7.2
368 2C9E PID 7.2
369 1VPV PLM 7.2
370 2FTB OLA 7.2
371 5HZ5 65X 7.2
372 3AQT RCO 7.2
373 1MGP PLM 7.2
374 5G61 FNY 7.2
375 2FV5 541 7.2
376 3WV1 WHH 7.2
377 3PPM JG1 7.2
378 1XM4 PIL 7.2
379 3ICT COA 7.2
380 3ICS COA 7.2
381 3IPQ 965 7.2
382 3GF4 UPG 7.2
383 1OPK P16 7.2
384 4OIC A8S 7.2
385 1EE0 CAA 7.2
386 6D28 NEC 7.2
387 5KOR GDP 7.2
388 3GF4 U5P 7.2
389 3GF4 FAD 7.2
390 1OPK MYR 7.2
391 1SAY PYR 7.2
392 3V1V GST 7.2
393 4RDZ MYR 7.2
394 5U97 PIT 7.2
395 1OKC CXT 7.2
396 2GFD RDA 7.2
397 6ECT SAM 7.2
398 3CLH NAD 7.2
399 1N9L FMN 7.33945
400 3BJC WAN 7.43243
401 2W1A TSA 7.43243
402 4BPM GSH 7.43243
403 5XJ8 NKO 7.46269
404 4DHY S41 7.46269
405 2D5Z L35 7.53425
406 5JO1 6LM 7.56757
407 1SJN DUP 7.64706
408 1X0P FAD 7.69231
409 5N7O 69Y 7.69231
410 1W96 S1A 7.77027
411 4ZW3 4S9 7.77027
412 3RGA ILD 7.77385
413 2QJY SMA 7.80669
414 6EVN PRO PRO GLY PRO ALA GLY PRO PRO GLY 7.84314
415 5LOF 70R 8
416 2QE4 JJ3 8
417 1GNI OLA 8
418 3O01 DXC 8
419 5YWX GSH 8
420 5YWX 93C 8
421 5AAV GW5 8
422 2BJ4 OHT 8
423 3UUA 0CZ 8
424 3UUD EST 8
425 2QZO KN1 8
426 3X1M COA 8
427 2QA8 GEN 8
428 3X01 AMP 8
429 3MBG FAD 8
430 4LA7 A1O 8
431 5WRE 7TL 8
432 5JNN 6LM 8
433 2OHV NHL 8
434 4CZG QH3 8
435 3NMV PYV 8
436 1N83 CLR 8
437 4LBP 1WG 8
438 3U5S FAD 8
439 3O55 FAD 8
440 3R9V DXC 8
441 5AE9 OKO 8
442 1H9G COA MYR 8
443 6C7D EOJ 8
444 3ETG GTP 8
445 2QE0 NAP 8
446 3ETG GLU 8
447 3ETG NDP 8
448 4DK7 0KS 8
449 5XK9 DMA 8
450 5XK9 GST 8
451 4W97 UCA 8
452 2EG5 XTS 8
453 4WZV E40 8
454 1M2T ADE 8
455 1WUB OTP 8
456 5EUD 5S6 8
457 2IYA ZIO 8
458 2BHZ MAL 8
459 2BYC FMN 8.0292
460 1T8U UAP SGN IDS SGN 8.08823
461 5W8Q BU4 8.10811
462 4QVX 3CQ 8.38323
463 1BII ARG GLY PRO GLY ARG ALA PHE VAL THR ILE 8.40336
464 2YNE NHW 8.44595
465 2YNE YNE 8.44595
466 2YNC YNC 8.44595
467 4QOM PYG 8.44595
468 4XRZ SI6 8.44595
469 2Z6D FMN 8.46154
470 3CR4 PNT 8.69565
471 3F3E LEU 8.78378
472 4F4P 0SB 8.79121
473 3COW 52H 8.8
474 1JF0 CZH 8.8
475 5MBC FMN 8.8
476 2AMV BIN 8.8
477 2V0U FMN 8.8
478 2WKQ FMN 8.8
479 4V24 GYR 8.8
480 2EVL GAL SPH EIC 8.8
481 6CAY ERG 8.8
482 5EFW FMN 8.8
483 3TDC 0EU 8.8
484 5OLK DTP 8.8
485 1OQC FAD 8.8
486 4YDQ ANP 8.8
487 4YDQ HFG 8.8
488 6ALW BNV 8.8
489 6ALW BMJ 8.8
490 2E9L OLA 8.8
491 1Z3C SA8 8.8
492 4RFM 3P6 8.8
493 2E9L PLM 8.8
494 2E9L BGC 8.8
495 5HM3 649 8.8
496 3LOO B4P 8.8
497 2ZKJ ADP 8.8
498 1BUC CAA 8.8
499 2V57 PRL 8.8
500 2EW5 Y12 8.83978
501 2VWA PTY 8.91089
502 2B96 ANN 8.94309
503 1L0I PSR 8.97436
504 1ZT1 PHE GLU ALA ASN GLY ASN LEU ILE 9
505 3STD MQ0 9.09091
506 1MHC FME TYR PHE ILE ASN ILE LEU THR LEU 9.09091
507 1LEK GLU GLN TYR LYS PHE TYR SER VAL 9.09091
508 3HDY GDU 9.12162
509 3HDY FDA 9.12162
510 4EOX 0S5 9.12162
511 3HDY FAD 9.12162
512 2CB8 MYA 9.1954
513 2BTO GTP 9.25926
514 5BYK A3P 9.26641
515 5BYK OAQ 9.26641
516 1OW4 2AN 9.30233
517 3NJQ NJQ 9.32642
518 4P3H 25G 9.32642
519 4V1T ADP 9.375
520 1JR8 FAD 9.40171
521 1AWI PRO PRO PRO PRO PRO PRO PRO PRO PRO PRO 9.42029
522 3HCN CHD 9.45946
523 2Z7I 742 9.45946
524 4M4Q 21A 9.54357
525 5IF4 6AK 9.6
526 1T57 FMN 9.6
527 3G4G D71 9.6
528 3G58 988 9.6
529 3PXP MYR 9.6
530 5N9T 8QQ 9.6
531 5XWV 8H6 9.6
532 1XON PIL 9.6
533 5JF2 SF7 9.6
534 5LUN ARG 9.6
535 3GYT DL4 9.6
536 5LUN OGA 9.6
537 4Y9J UCC 9.6
538 5GK9 ACO 9.6
539 3IQE F42 9.6
540 3IQE H4M 9.6
541 2WSI FAD 9.6
542 1EKO I84 9.6
543 4RKK GLC GLC GLC GLC GLC GLC 9.6
544 2GTE VA 9.67742
545 1MT1 AG2 9.73451
546 1XZ3 ICF 9.77011
547 2WCJ M21 9.92908
548 3KP6 SAL 9.93377
549 4PVV HO4 10.1351
550 4U0S ADP 10.1351
551 5N8V KZZ 10.1449
552 5CHR 4NC 10.219
553 1UHK CZN 10.4
554 3P0K FAD 10.4
555 6ADI 9UO 10.4
556 4JD3 COA 10.4
557 5SVV FMN 10.4
558 6AYI C3G 10.4
559 5UC9 MYR 10.4
560 5CXI 5TW 10.4
561 5V3Y 5V8 10.4
562 3GL0 HXX 10.4
563 2HW1 ANP 10.4
564 2CIX CEJ 10.4
565 3OBK PBG 10.4
566 3UG4 AHR 10.4
567 3RDE OYP 10.473
568 4UNR QZE 10.4762
569 1N13 AG2 10.6195
570 6B5Q PPI CZS 2KY MLY 1XY 10.6667
571 2QQC AG2 10.7143
572 2QQD AG2 10.7143
573 4OYA 1VE 10.8108
574 4YSX E23 10.8108
575 5EK3 5PK 10.8108
576 4YSX EPH 10.8108
577 6GH1 ARG LEU PRO ALA LYS ALA PRO LEU LEU 11
578 5C9J DAO 11.1111
579 5C9J STE 11.1111
580 2Z9I GLY ALA THR VAL 11.1486
581 2R75 01G 11.1486
582 2XXP DSL 11.2
583 3L9R L9R 11.2
584 5LGD PLM 11.2
585 3RMK BML 11.2
586 3L9R L9Q 11.2
587 4E90 7RG 11.2
588 3LDW ZOL 11.2
589 1D6H COA 11.2
590 3RLF MAL 11.2
591 6C7R EO4 11.2
592 3ET1 ET1 11.2
593 5X4Q 7Z6 11.2
594 4ONA UW1 11.2
595 3ZCN ATP 11.2
596 4GBD MCF 11.2
597 3OGN 3OG 11.2903
598 4EES FMN 11.3043
599 3GWL FAD 11.3208
600 5OVC ACE GLU ALA GLN THR ARG LEU 11.4583
601 2PX6 DH9 11.4865
602 5AG3 3EB 11.4865
603 1D5Z ACE ALC ARG ALA ODA SER LEU NH2 11.7155
604 3T6E UQ9 11.8243
605 3T6E MQ9 11.8243
606 1FCZ 156 11.8243
607 2LBD REA 11.8243
608 3ZS7 ATP 11.8243
609 4D7M TDC 12
610 3QUG GIX 12
611 4PA0 2OW 12
612 4KBS PX2 12
613 2IFB PLM 12
614 5N69 2OW 12
615 4DJA DLZ 12
616 4DJA FAD 12
617 4ZVV GN0 12
618 3HB5 E2B 12
619 3HB5 NAP 12
620 4ZVV NAD 12
621 1SBR VIB 12
622 4CRL C1I 12
623 3RWP ABQ 12
624 5T70 THR SER ASN LEU GLN GLU GLN ILE GLY TRP 12.1212
625 5U98 1KX 12.1212
626 5U98 VAL THR THR ASP ILE GLN VAL LYS VAL 12.1212
627 5XS3 VAL ARG SER ARG ARG CYS LEU ARG LEU 12.2449
628 4YV5 SVR 12.2951
629 5D9J 0N8 12.2995
630 4YUS FMN 12.5
631 4GAA BES 12.5
632 4PGK Y69 12.7049
633 1Y75 NAG 12.7119
634 3HY2 ATP 12.7273
635 2XCG XCG 12.8
636 4R38 RBF 12.8
637 3LSJ PLM COA 12.8
638 1N1G BCP 12.8
639 4YC9 4C1 12.8
640 2P1C GG3 12.8
641 6B5G CQY 12.8
642 6B5G NAD 12.8
643 5HTL C2E 12.8
644 3QMK SGN IDS SGN IDS 12.8
645 3LSJ COA PLM 12.8
646 5FH7 5XL 12.9032
647 1FK5 OLA 12.9032
648 1XVB BHL 12.9412
649 2ALG DAO 13.0435
650 5DKK FMN 13.1034
651 3KMR EQN 13.5135
652 1DKF BMS 13.5135
653 1DKF OLA 13.5135
654 3G08 FEE 13.6
655 5TO8 7FM 13.6
656 4Y30 49L 13.6
657 4IGH ORO 13.6
658 4IGH FMN 13.6
659 4IGH 1EA 13.6
660 4DL8 UMP AF3 PO4 13.6
661 6BQC LOP 13.6
662 4Y30 SAH 13.6
663 1W3R 2MN 13.6
664 1W3R PYR 13.6
665 5X8Q 82R 13.6364
666 3LLI FAD 13.7931
667 1XAP TTB 13.8514
668 4DM8 REA 13.8514
669 2GJ3 FAD 14.1667
670 2PEH LYS ARG LYS SER ARG TRP ASP GLU THR PRO 14.2857
671 1YOK P6L 14.4
672 3WCA FPS 14.4
673 5UNJ RJW 14.4
674 5MW4 5JU 14.4
675 1YUC EPH 14.4
676 1ZDU P3A 14.4
677 3MG9 GHP 3MY 3FG GHP GHP OMY 3FG 14.4
678 4LY9 S6P 14.4
679 3HLX PQQ 14.4
680 2Z6C FMN 14.7287
681 3F5O UOC COA 14.8649
682 5BVT PAM 14.9254
683 3VVY ET 14.9485
684 2GWH PCI 15.2
685 6AYB KKK 15.2
686 4ZVI 4S4 15.2
687 4MRV HGD 15.2
688 4MRP GSH 15.2
689 3HKW IX6 15.2
690 4MRS GDS 15.2
691 6CR2 LFV 15.2
692 6BMS PLM 15.2027
693 5Z84 TGL 15.2174
694 5ZCO TGL 15.2174
695 2DYS TGL 15.2174
696 5ZCO PGV 15.2174
697 5Z84 PGV 15.2174
698 2DYR PGV 15.2174
699 2DYS PGV 15.2174
700 2DYR PEK 15.2174
701 2DYR TGL 15.2174
702 2DYS PEK 15.2174
703 5Z84 PEK 15.2174
704 5W97 CHD 15.2174
705 5ZCO PEK 15.2174
706 5MOB A8S 15.5172
707 2BCG GER 16
708 3QQA TCH 16
709 6GG9 FMN 16
710 5DJT FMN 16.3934
711 5DJU FMN 16.3934
712 1UVC STE 16.4835
713 4QBK 3NZ 16.4948
714 4P53 NAI 16.5541
715 5TIV A3P 16.6008
716 2A06 SMA 16.6667
717 4Q6R 30J 16.8
718 3JRX S1A 17.2297
719 1HFS L04 17.5
720 3P7N FMN 17.6
721 3T58 FAD 17.9054
722 4F4S EFO 18.4211
723 4QWT ACD 18.5811
724 5IM3 DTP 19.2
725 2WPX ACO 19.2
726 1HK8 DGT 19.2
727 2A1L PCW 20
728 1NQ7 HIS LYS ILE LEU HIS ARG LEU LEU GLN GLU 20
729 3GWT 066 20
730 5OM2 DXT 20
731 4WRI OKA 20
732 4YDU ADP 20
733 1N4H REA 20
734 5V03 658 20.5882
735 2E2R 2OH 20.8
736 2EIX FAD 20.8
737 2VAT COA 20.8
738 5IUY BOG 20.8
739 5LXT GDP 21.6
740 5LXT 7AK 21.6
741 2H7C COA 21.6
742 5LXT GTP 21.6
743 5EYP GDP 21.6
744 5ITZ GDP 21.6
745 5EIB GTP 21.6
746 3RYC GDP 21.6
747 4LNU GDP 21.6
748 5EYP LOC 21.6
749 4WQ2 3SU 21.9653
750 4N4J HG1 22.4
751 3E7O 35F 22.4
752 3NBK PNS 22.4
753 5TK8 7D5 22.4
754 3BKR PLM 24
755 6EQ8 BQZ 24
756 3WH1 NAG NAG NAG NAG 24
757 6CS9 PIO 26.8293
758 2GCE SFC 27.2
759 4P42 PEE 30.4
760 4F97 GDP 32
761 2QZT PLM 33.3333
762 2RH1 CLR 34.1216
763 2RH1 CAU 34.1216
764 3HUJ AGH 36.8
765 6BJ3 ILE PRO LEU THR GLU GLU ALA GLU LEU 39.2
766 5C0C ARG GLN PHE GLY PRO ASP TRP ILE VAL ALA 40
767 5ISZ GLY ILE LEU GLY PHE VAL PHE THR LEU 40.8
768 3QUZ QUV 41.6
769 3SCM LGN 41.6
770 4OGQ 2WA 41.9355
771 4OGQ SQD 41.9355
772 3TJH SER PRO LEU ASP SER LEU TRP TRP ILE 42.4
773 5JHD GLY ILE LEU GLY PHE VAL PHE THR LEU 42.4
774 1OGA GLY ILE LEU GLY PHE VAL PHE THR LEU 43.2
775 2FKW RG1 43.3962
776 3RUG DB6 44.8
777 3QDJ ALA ALA GLY ILE GLY ILE LEU THR VAL 44.8
778 4WO4 JLS 44.8
779 3QFJ LEU LEU PHE GLY PHE PRO VAL TYR VAL 44.8
780 1FO0 ILE ASN PHE ASP PHE ASN THR ILE 47.3214
Pocket No.: 4; Query (leader) PDB : 5C1M; Ligand: CLR; Similar sites found with APoc: 280
This union binding pocket(no: 4) in the query (biounit: 5c1m.bio1) has 13 residues
No: Leader PDB Ligand Sequence Similarity
1 5CSD ACD None
2 6CHP F0Y None
3 1BWO LPC None
4 5K53 STE 0.763359
5 6CB2 OLC 1.02389
6 5K52 OCD 2.26415
7 3P9T TCL 2.28311
8 2XSU PIE 2.4
9 5DLY SAH 2.4
10 3IIS PID 2.64901
11 5B4B LP5 2.82258
12 1R6N 434 2.8436
13 5LJ0 6XX 3.07692
14 5NI5 8YB 3.125
15 5UWA 8ND 3.2
16 2FP2 TSA 3.2
17 4POJ 2VP 3.2
18 4M8E 29V 3.2
19 2E3N 6CM 3.2
20 3NTA COA 3.2
21 5AZC PGT 3.2
22 2HPS CTZ 3.22581
23 4O4Z N2O 3.24675
24 4Q9M FPP 3.25203
25 4Q9M 2ZW 3.25203
26 4QJR PIZ 3.26531
27 3D78 NBB 3.36134
28 6BR9 PGV 3.37838
29 4WGF HX2 3.41463
30 6AYH C3G 3.48259
31 6BR8 PGV 3.57143
32 4NAT ADP 3.75
33 3ET3 ET1 3.76712
34 3B1M KRC 3.88693
35 2HFP NSI 3.90071
36 1GHE ACO 3.9548
37 2C43 COA 4
38 3V66 D3A 4
39 3EE4 MYR 4
40 1P1M MET 4
41 1YKD CMP 4
42 3NHT U46 4
43 5EEH P9P 4
44 2BIF BOG 4
45 5HCV 60R 4
46 4R29 SAM 4
47 1I7L ATP 4
48 2YOO K2B 4
49 1FM9 9CR 4.04412
50 3VHZ L2P GLC MAN SGA 4.19847
51 4XU6 TDA 4.28571
52 5C2H 4PX 4.39189
53 5C2H 4XU 4.39189
54 5WX3 COA 4.39189
55 1POC GEL 4.47761
56 2NNQ T4B 4.58015
57 3SFI 3SF 4.66102
58 4FDV 0UK 4.8
59 1UDY FAD 4.8
60 1UDY CS8 4.8
61 5V13 JH3 4.8
62 4BNU 9KQ 4.8
63 2Y31 SMQ 4.8
64 5CX6 CDP 4.8
65 4PYW ACE THR THR ALA ILE NH2 4.8
66 4J7Q B7N 5.06757
67 3NT6 COA 5.06757
68 3NTD COA 5.06757
69 3ABA FLI 5.40541
70 5N5U 7N8 5.40541
71 4FC7 COA 5.41516
72 4FC7 NAP 5.41516
73 5FVJ ACO 5.42169
74 3R1V AZB 5.51181
75 3E8T UQ8 5.6
76 5G57 6M5 5.6
77 5F1R 42O 5.6
78 2I0G I0G 5.6
79 2XFH CL6 5.6
80 1PZO CBT 5.6
81 3E3U NVC 5.6
82 4GU5 FAD 5.6
83 3QWB NDP 5.6
84 3F5K CE5 5.6
85 5J6A P46 5.6
86 1U3R 338 5.6
87 5M37 9SZ 5.65217
88 5M36 9SZ 5.67686
89 1ESM COA 5.6962
90 6C5B SAH 5.74324
91 1NP7 FAD 6.08108
92 2D5X L35 6.16438
93 5MWE TCE 6.17284
94 5W7B MYR 6.4
95 4CVZ TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 6.4
96 1YQZ FAD 6.4
97 3WYJ H78 6.4
98 5W7D PX8 6.4
99 4TWP AXI 6.4
100 5LPA 71R 6.4
101 5LPA ATP 6.4
102 4RC8 STE 6.4
103 2JBZ COA 6.4
104 3QKD HI0 6.4
105 4RHP PEF 6.4
106 2UXI G50 6.4
107 1LN1 DLP 6.4
108 2OBD PCW 6.41892
109 2OBD 2OB 6.41892
110 3OKI OKI 6.43777
111 4OIV XX9 6.63717
112 4NE2 SH2 6.75676
113 4EI7 GDP 6.75676
114 5N26 CPT 7.14286
115 2ZCQ B65 7.16724
116 2FV5 541 7.2
117 6B21 C9V 7.2
118 3ICT COA 7.2
119 3ICS COA 7.2
120 1XMY ROL 7.2
121 5OHJ 9VE 7.2
122 1XM4 PIL 7.2
123 1XMU ROF 7.2
124 4I6G FAD 7.2
125 5GUE GGS 7.2
126 4IAE 1DX 7.2
127 2C9E PID 7.2
128 5XJ7 87O 7.46269
129 1W96 S1A 7.77027
130 3O01 DXC 8
131 1GNI OLA 8
132 3ETG GLU 8
133 3ETG NDP 8
134 3ETG GTP 8
135 2QE4 JJ3 8
136 5AAV GW5 8
137 5LOF 70R 8
138 2BJ4 OHT 8
139 1JGS SAL 8
140 4KWD JF2 8
141 6C7D EOJ