Receptor
PDB id Resolution Class Description Source Keywords
5BV3 2.25 Å EC: 3.6.1.59 YEAST SCAVENGER DECAPPING ENZYME IN COMPLEX WITH M7GDP SACCHAROMYCES CEREVISIAE (STRAIN ATCC S288C) SCAVENGER DECAPPING ENZYME CAP STRUCTURE DECAPPING ENZYMESUBSTRATE INHIBITION PROTEIN DYNAMICS HYDROLASE
Ref.: AN EXCESS OF CATALYTICALLY REQUIRED MOTIONS INHIBIT SCAVENGER DECAPPING ENZYME. NAT.CHEM.BIOL. V. 11 697 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL C:403;
D:404;
D:403;
A:404;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
35.453 Cl [Cl-]
SO4 B:401;
A:403;
A:402;
D:402;
B:402;
D:401;
C:402;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
M7G C:401;
A:401;
Valid;
Valid;
none;
none;
Kd = 196 uM
459.243 C11 H19 N5 O11 P2 CN1CN...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5BV3 2.25 Å EC: 3.6.1.59 YEAST SCAVENGER DECAPPING ENZYME IN COMPLEX WITH M7GDP SACCHAROMYCES CEREVISIAE (STRAIN ATCC S288C) SCAVENGER DECAPPING ENZYME CAP STRUCTURE DECAPPING ENZYMESUBSTRATE INHIBITION PROTEIN DYNAMICS HYDROLASE
Ref.: AN EXCESS OF CATALYTICALLY REQUIRED MOTIONS INHIBIT SCAVENGER DECAPPING ENZYME. NAT.CHEM.BIOL. V. 11 697 2015
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5BV3 Kd = 196 uM M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5BV3 Kd = 196 uM M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5BV3 Kd = 196 uM M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: M7G; Similar ligands found: 11
No: Ligand ECFP6 Tc MDL keys Tc
1 M7G 1 1
2 MGT 0.910256 1
3 M7M 0.541667 0.963855
4 G8D 0.537634 0.914634
5 TPG 0.525 0.920455
6 8GT 0.494845 0.914634
7 CDP 0.43617 0.829268
8 UDP 0.430108 0.780488
9 8GM 0.412371 0.902439
10 8OD 0.411765 0.77907
11 8GD 0.407767 0.872093
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5BV3; Ligand: M7G; Similar sites found with APoc: 1
This union binding pocket(no: 1) in the query (biounit: 5bv3.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 1ST0 GTG 48.6647
Pocket No.: 2; Query (leader) PDB : 5BV3; Ligand: M7G; Similar sites found with APoc: 1
This union binding pocket(no: 2) in the query (biounit: 5bv3.bio2) has 22 residues
No: Leader PDB Ligand Sequence Similarity
1 1ST0 GTG 48.6647
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