Receptor
PDB id Resolution Class Description Source Keywords
5AWM 1.79 Å EC: 2.7.11.24 THE CRYSTAL STRUCTURE OF JNK FROM DROSOPHILA MELANOGASTER RE EVOLUTIONARILY CONSERVED TOPOLOGY WITH THAT OF MAMMALIAN JNP ROTEINS. DROSOPHILA MELANOGASTER C-JUN N-TERMINAL KINASE MAP KINASE DROSOPHILA JNK PATHWAYTRANSFERASE
Ref.: THE CRYSTAL STRUCTURE OF JNK FROM DROSOPHILA MELANO REVEALS AN EVOLUTIONARILY CONSERVED TOPOLOGY WITH T MAMMALIAN JNK PROTEINS. BMC STRUCT.BIOL. V. 15 17 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ANP A:401;
Valid;
none;
submit data
506.196 C10 H17 N6 O12 P3 c1nc(...
MG A:402;
A:403;
Part of Protein;
Invalid;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5AWM 1.79 Å EC: 2.7.11.24 THE CRYSTAL STRUCTURE OF JNK FROM DROSOPHILA MELANOGASTER RE EVOLUTIONARILY CONSERVED TOPOLOGY WITH THAT OF MAMMALIAN JNP ROTEINS. DROSOPHILA MELANOGASTER C-JUN N-TERMINAL KINASE MAP KINASE DROSOPHILA JNK PATHWAYTRANSFERASE
Ref.: THE CRYSTAL STRUCTURE OF JNK FROM DROSOPHILA MELANO REVEALS AN EVOLUTIONARILY CONSERVED TOPOLOGY WITH T MAMMALIAN JNK PROTEINS. BMC STRUCT.BIOL. V. 15 17 2015
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 16 families.
1 5AWM - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
70% Homology Family (41)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 3TTI ic50 = 0.006 uM KBI C21 H23 F3 N6 O2 c1c(cc(c(c....
2 3TTJ ic50 = 0.21 uM JBI C23 H23 F N6 O COc1ccc(cc....
3 1JNK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
4 4H3B Kd = 17.2 uM VAL VAL ARG PRO GLY SER LEU ASP LEU PRO n/a n/a
5 3KVX ic50 = 0.148 uM FMY C26 H27 F N8 O2 c1cc(ccc1/....
6 4H39 Kd = 0.8 uM PRO LYS ARG PRO THR THR LEU ASN LEU PHE n/a n/a
7 4AWI ic50 = 1 uM AQ2 C21 H25 N3 O4 S2 CC(C)c1cc2....
8 2O0U ic50 = 3.2 uM C0M C27 H28 N4 O2 S c1ccc2c(c1....
9 2P33 ic50 = 57 nM J07 C20 H23 Cl N6 O CCNC(=O)N1....
10 2ZDU - 446 C28 H23 Br N2 O6 COC(=O)C1=....
11 2B1P ic50 = 3 nM AIZ C26 H26 Cl N5 O3 CN(C)CCCC(....
12 2OK1 Ki = 0.55 uM 33A C21 H17 Cl N4 O c1ccc(cc1)....
13 3OXI ic50 = 2.2 uM SYY C12 H11 N O3 S2 COC(=O)c1c....
14 3OY1 ic50 = 0.016 uM 589 C28 H31 N5 O2 c1ccc2cc(c....
15 2ZDT - 46C C26 H20 Cl N O4 CCC(=O)C1=....
16 3ELJ - GS7 C22 H21 F N6 O4 S COc1cc(ccc....
17 3FI2 ic50 = 0.025 uM JK1 C26 H25 N5 O5 COc1cc(cc(....
18 4L7F ic50 = 160 nM 1V5 C26 H26 F N5 O2 c1cc(ccc1C....
19 2WAJ ic50 = 0.398 uM SNB C16 H13 Br Cl N O COc1cc2c(c....
20 4QTD ic50 = 1080 nM 38Z C33 H33 N9 O2 c1cnc(nc1)....
21 3G9L Ki = 0.74 uM J67 C25 H19 F N2 O4 c1ccc(cc1)....
22 4Y46 ic50 = 11 nM 4F2 C22 H32 N6 O2 CC(C)NC(=O....
23 1PMN ic50 = 7.1 nM 984 C25 H30 Cl2 N6 CCCn1c(c(n....
24 3FI3 ic50 = 12 nM JK2 C29 H25 F N4 O4 COc1cc(cc(....
25 2O2U ic50 = 4 uM 738 C16 H13 F N2 O S c1ccc(c(c1....
26 4W4V ic50 = 866 nM 3H8 C23 H19 Cl N6 O2 Cc1cc(ccn1....
27 3DA6 - BZ9 C28 H23 N7 O Cc1cc(c2cc....
28 2R9S ic50 = 0.15 uM 255 C24 H24 N4 O2 S CC(C)(C)NS....
29 4Y5H ic50 = 15 nM 519 C20 H30 N6 O2 CC(C)NC(=O....
30 4X21 Kd = 36 nM 3WH C20 H23 I N6 O CCNC(=O)N1....
31 3RTP ic50 = 7 nM 34I C18 H14 N6 O2 S c1ccc2c(c1....
32 3PZE - CFK C12 H11 N3 O2 S c1ccc(cc1)....
33 4Z9L ic50 = 1.6 nM 880 C27 H34 Cl2 N6 CCCn1c(c(n....
34 4WHZ ic50 < 1 nM 3NL C24 H23 Cl N8 O2 c1ccc(c(c1....
35 4W4Y ic50 = 3034 nM 3HQ C24 H22 N6 O2 Cc1ccc(cc1....
36 4W4W ic50 = 6630 nM 3HJ C23 H20 N6 O2 Cc1cc(ccn1....
37 3G90 Ki = 0.44 uM J72 C17 H12 F2 N2 O4 c1cc2c(cc1....
38 1PMV ic50 = 150 nM 537 C14 H8 N2 O c1ccc2c(c1....
39 5AWM - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
40 3NPC - B96 C31 H37 N5 O3 Cc1ccc(cc1....
41 3E7O ic50 = 120 nM 35F C20 H14 N6 O2 c1cc(cc(c1....
50% Homology Family (257)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 3GCV Kd = 74 nM SS6 C29 H30 N8 O Cc1cccc(c1....
2 3L8S Kd = 99 nM BFF C20 H24 Br F2 N5 O3 S c1c(cc(c(c....
3 3RIN ic50 = 1.3 nM I2O C23 H24 N2 O2 Cc1ccc(cc1....
4 5N65 - 8OT C20 H18 N4 S c1ccc(cc1)....
5 4FA2 - SB0 C20 H21 F N4 O2 COc1nccc(n....
6 2GHM - LIC C24 H28 Cl N5 O3 C[C@@H](C(....
7 1W84 ic50 = 35 uM L12 C15 H14 N2 c1ccc2c(c1....
8 4EH5 - IRG C17 H16 N4 c1ccc(cc1)....
9 2BAK Kd = 37 nM AQZ C32 H37 N7 O4 Cc1ccc(cc1....
10 3HV6 ic50 = 5500 nM R39 C27 H35 N5 O3 Cc1ccc(cc1....
11 3HP2 - P36 C19 H16 Br N O2 c1ccc(cc1)....
12 1WBO ic50 = 1 mM 2CH C6 H5 Cl O c1ccc(c(c1....
13 4KIQ ic50 = 23 nM 1RA C23 H23 N3 O4 CCOC(=O)n1....
14 3GC7 ic50 = 0.4 nM B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
15 4EH6 - IRG C17 H16 N4 c1ccc(cc1)....
16 5MTX Kd = 17.7 nM FJI C34 H31 F N4 O5 c1ccc(cc1)....
17 2ZB0 Ki = 0.24 uM GK3 C24 H18 N4 O2 Cc1ccc(cc1....
18 2GTM ic50 = 542 nM LID C19 H15 Cl F2 N6 CCn1c2c(cn....
19 5N66 - B96 C31 H37 N5 O3 Cc1ccc(cc1....
20 2YIX Kd = 3.3 nM YIX C19 H23 N5 O S CCNC(=O)NC....
21 3OCG ic50 = 3 nM OCG C21 H18 N6 O3 Cc1ccc(cc1....
22 1BL7 - SB4 C18 H19 F N6 c1cc(ccc1c....
23 3P7C ic50 = 0.022 uM P7C C25 H33 Cl2 N5 O3 S CC(C)(C)c1....
24 5TBE Kd = 4.4 nM 78L C33 H30 F2 N4 O4 S c1cc(sc1)C....
25 4KIP ic50 = 7 nM 1R9 C21 H18 Cl N3 O2 S Cc1ccc(cc1....
26 2EWA - SB2 C21 H16 F N3 O S C[S@](=O)c....
27 2GHL - LIB C23 H26 Cl N5 O3 C[C@@H](C(....
28 1ZZ2 ic50 = 6 uM B11 C24 H26 F N3 O4 S c1ccc(c(c1....
29 3ZSI - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
30 2YIW - YIW C30 H33 N7 O S CC(C)c1nnc....
31 1A9U - SB2 C21 H16 F N3 O S C[S@](=O)c....
32 1M7Q ic50 = 2.6 nM DQO C24 H20 Cl2 F2 N4 O c1cc(c(c(c....
33 5MTY Kd = 1.3 nM HB9 C29 H23 F2 N3 O4 S c1cc(sc1)C....
34 4EH7 - IRG C17 H16 N4 c1ccc(cc1)....
35 1YQJ ic50 = 7.3 nM 6NP C30 H27 N5 c1ccc(cc1)....
36 4EH3 - NAR C15 H12 O5 c1cc(ccc1[....
37 4AA5 ic50 = 6.7 nM NQB C24 H27 N5 O2 Cc1ccc(cc1....
38 1OVE ic50 = 0.74 nM 358 C26 H22 Cl2 F2 N2 O c1cc(c(c(c....
39 3UVP ic50 = 0.035 uM 048 C24 H21 F N2 O2 c1ccc(cc1)....
40 5N67 - 8ON C28 H30 N6 O CC(=O)N1CC....
41 3NNV ic50 = 27 nM 437 C25 H26 N4 O2 CC(C)(C)c1....
42 3CTQ ic50 = 40 nM 337 C30 H34 N6 O5 S Cc1ccc(cc1....
43 3IW7 - IPK C26 H26 N4 O S c1ccc(cc1)....
44 3ITZ ic50 = 1.4 nM P66 C21 H15 Cl F2 N6 O c1cc(c(c(c....
45 2ZB1 Ki = 0.48 uM GK4 C21 H21 N3 O2 Cc1ccc(cc1....
46 3HV5 ic50 = 150 nM R24 C30 H29 N7 O3 Cc1ccc(cc1....
47 1WBW ic50 = 44 uM LI4 C16 H14 N2 O c1ccc2c(c1....
48 3P79 ic50 = 2.3 uM P79 C24 H29 N5 O4 S CC(C)(C)c1....
49 3HV7 ic50 = 90 nM 1AU C24 H25 N5 O CC(C)(C)c1....
50 3GFE ic50 = 3.2 nM P37 C24 H21 F2 N5 O2 Cc1ccc(cc1....
51 3ZYA - 2A8 C21 H18 N2 O c1ccc2c(c1....
52 2RG5 ic50 = 3.1 nM 279 C19 H22 N6 O3 CCNC(=O)c1....
53 3L8X ic50 = 10 nM N4D C20 H18 N6 O Cc1ccc(cc1....
54 3GCS Kd = 56 nM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
55 3ZS5 - SB2 C21 H16 F N3 O S C[S@](=O)c....
56 3D83 Ki = 4.4 nM GK6 C28 H30 N4 O3 Cc1ccc(cc1....
57 1YW2 ic50 = 141 nM PGJ C22 H18 F N3 O5 CCOC[N@]1C....
58 1W82 ic50 = 196 nM L10 C20 H21 Cl N4 O CC(C)(C)C1....
59 3ZSG - T75 C24 H21 N3 O S CCc1nc(c(s....
60 5TCO Kd = 3.14 nM 79Q C35 H33 F N4 O4 c1ccc(cc1)....
61 4EH8 - IRG C17 H16 N4 c1ccc(cc1)....
62 3GCP Kd = 15 nM SB2 C21 H16 F N3 O S C[S@](=O)c....
63 3HLL Ki = 0.0058 uM I45 C22 H19 Br F2 N2 O3 Cc1ccc(cc1....
64 1ZZL ic50 = 5 nM TZY C18 H15 F N4 O CC(C)c1nnc....
65 2RG6 ic50 = 2.2 nM 287 C25 H26 N6 O3 Cc1ccc(cc1....
66 3MPT ic50 = 0.25 uM 1GK C18 H16 N2 O3 Cc1ccccc1C....
67 1BL6 - SB6 C18 H16 F N3 c1cc(ccc1c....
68 3NNW ic50 = 9 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
69 3GI3 Kd < 1.8 nM B10 C33 H39 N5 O5 S CC(C)(C)c1....
70 3K3J - I46 C14 H9 F2 N3 c1cc(ccc1c....
71 3HEC ic50 = 70 uM STI C29 H31 N7 O Cc1ccc(cc1....
72 1IAN - D13 C21 H16 I N3 O S C[S@@](=O)....
73 3FC1 - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
74 3MVM ic50 = 13 nM 39P C22 H23 N7 O3 CCCNC(=O)c....
75 3NNU ic50 = 48 nM EDB C22 H17 Cl2 N5 O2 S c1cc(cc(c1....
76 1W7H ic50 = 1 mM 3IP C12 H12 N2 O c1ccc(cc1)....
77 3U8W ic50 = 1 nM 09J C24 H21 Cl F N5 O2 CCN1C(=O)C....
78 1WBS ic50 = 0.63 uM LI2 C26 H25 F N4 O2 c1cc2c(cc1....
79 4E6C Kd ~ 15 uM 0O8 C25 H53 N O4 P CCCCCCCCCC....
80 5N68 - 8OK C26 H27 N5 O c1ccc(cc1)....
81 1WBV ic50 = 162 uM LI3 C19 H18 F N3 O2 c1cc2c(cc[....
82 4EH2 - IRG C17 H16 N4 c1ccc(cc1)....
83 3HA8 - 5JZ C36 H38 N8 O5 CCOc1nc(nc....
84 3HEG ic50 = 0.057 uM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
85 2ZAZ Ki = 0.4 uM GK1 C20 H15 N3 O2 S Cc1ccc(cc1....
86 3HP5 - I46 C14 H9 F2 N3 c1cc(ccc1c....
87 5ML5 ic50 = 10 nM 1VI C26 H25 F N4 O3 S COc1ccc(c(....
88 4DLI Kd = 2.4 uM IRG C17 H16 N4 c1ccc(cc1)....
89 3P78 ic50 = 0.11 uM P78 C24 H27 N3 O4 S2 CC(C)(C)c1....
90 4EH9 - IRG C17 H16 N4 c1ccc(cc1)....
91 1YWR ic50 = 32 nM LI9 C27 H29 F N6 O C[C@@H](c1....
92 3IW5 Kd = 0.839 uM DF3 C28 H24 F3 N3 O4 S c1ccc2c(c1....
93 3HV3 ic50 = 900 nM R49 C30 H31 N7 O Cc1cccc(c1....
94 4A9Y - RNY C32 H37 N7 O4 Cc1ccc(cc1....
95 3GCU - R48 C29 H30 N8 O Cc1ccc(cc1....
96 1OUY ic50 = 4.3 nM 094 C24 H18 Cl2 F2 N4 O S c1cc(c(c(c....
97 3D7Z Ki = 12 nM GK5 C22 H24 N2 O2 Cc1ccc(cc1....
98 2YIS - YIS C35 H34 Cl N7 O3 S2 CC(C)(C)c1....
99 1OUK ic50 = 0.13 nM 084 C28 H29 F3 N6 C[C@@H](c1....
100 3BV2 Ki = 0.44 nM P38 C33 H32 N8 O3 Cc1ccc(cc1....
101 4R3C - GG5 C14 H10 F N3 c1cc(ccc1c....
102 4L8M ic50 = 0.001 uM F46 C33 H30 F N3 O5 c1ccc(cc1)....
103 4E6A - 0O9 C32 H65 O10 P CCCCCCCCCC....
104 1WBN ic50 = 0.35 uM L09 C20 H22 Cl N5 O2 CC(C)(C)c1....
105 2QD9 ic50 = 13 nM LGF C27 H24 F2 N6 O5 COC1=NC2=N....
106 3HUC Kd = 1030 nM G97 C20 H16 N6 O C=CC(=O)Nc....
107 3HL7 Ki = 0.023 uM I47 C20 H20 Cl N5 O2 c1cc(ccc1c....
108 4EHV - IRG C17 H16 N4 c1ccc(cc1)....
109 2GTN ic50 = 4 nM LIE C20 H16 F3 N5 O CC(C)n1c2c....
110 3HRB ic50 = 21 nM I39 C19 H14 F2 N2 O2 Cc1ccccc1c....
111 3BX5 ic50 = 1.5 nM 304 C17 H22 N4 O2 S CC[C@@H](C....
112 3HVC ic50 = 600 nM GG5 C14 H10 F N3 c1cc(ccc1c....
113 2GFS ic50 = 0.7 uM PQB C19 H18 F N3 O4 c1cc(cc(c1....
114 5N63 - 8OW C21 H17 F N4 c1ccc(cc1)....
115 2NPQ Kd = 3.08 uM BOG C14 H28 O6 CCCCCCCCO[....
116 3IW6 Kd = 3.29 uM PP0 C23 H31 N3 O3 CCn1c(c(c(....
117 3S4Q ic50 = 4 nM NK0 C25 H23 N5 O2 Cc1ccc(cc1....
118 2BAJ Kd = 4 nM 1PP C20 H20 Cl2 N4 O CC(C)(C)c1....
119 3ROC - 29B C14 H10 F N3 c1cc(ccc1c....
120 3NWW ic50 = 7 nM 3NW C24 H34 N8 O S CCNC(=O)NC....
121 1W83 ic50 = 0.065 uM L11 C23 H25 Cl F N3 O3 c1cc(cnc1)....
122 3ZSH - 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
123 3IPH Ki = 0.0000251 mM G11 C21 H23 N3 O2 Cc1ccc(cc1....
124 3P7B ic50 = 0.018 uM P7B C25 H28 N4 O3 S CC(C)(C)c1....
125 3GCQ Kd = 342 nM 1BU C29 H30 N8 O Cc1cccc(c1....
126 4F9Y Ki = 184 nM LM3 C21 H18 N4 CN(C)c1cc(....
127 2BAL Kd = 490 nM PQA C21 H21 F N4 O2 c1cc(cc(c1....
128 3HUB Kd = 8.2 nM 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
129 4F9W Ki = 114 nM LM4 C21 H18 N4 CN(C)c1cc(....
130 3P5K ic50 = 0.076 uM P5K C24 H27 N3 O4 S2 CC(C)(C)c1....
131 2I0H ic50 = 9 nM 222 C27 H19 Cl2 F N4 O3 c1ccc2c(c1....
132 1ZYJ ic50 = 1.5 uM BI5 C19 H16 N2 O2 c1ccc(cc1)....
133 3K3I - JZJ C18 H16 Br N3 c1ccc2c(c1....
134 1WBT ic50 = 0.34 uM WBT C26 H25 F N4 O2 c1cc(cc2c1....
135 1BMK - SB5 C17 H16 F N5 c1cc(ccc1c....
136 3E92 Ki = 10 nM G6A C21 H21 N3 O2 Cc1ccc(cc1....
137 3P7A ic50 = 0.52 uM P7A C23 H27 N3 O3 S2 CC(C)(C)c1....
138 3NNX ic50 = 11 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
139 4EH4 - IRG C17 H16 N4 c1ccc(cc1)....
140 1KV1 Kd = 1.16 uM BMU C15 H19 Cl N4 O CC(C)(C)c1....
141 3KF7 ic50 = 40 nM L9G C22 H18 F2 N4 O Cc1ccc(cc1....
142 4KIN ic50 = 4.8 nM 1M8 C22 H19 Cl N2 O2 S Cc1ccc(cc1....
143 4AA4 ic50 = 9 nM QC0 C25 H25 N5 O3 Cc1ccc(cc1....
144 3E93 Ki = 1.4 nM 19B C30 H32 N4 O3 Cc1ccc(cc1....
145 4AAC ic50 = 16 nM AAV C24 H24 N6 O3 Cc1ccc(cc1....
146 4AA0 ic50 = 35 nM AA0 C30 H33 N7 O3 Cc1ccc(cc1....
147 1OZ1 ic50 = 6.5 nM FPH C18 H12 F N3 O c1cc2c(c(c....
148 5N64 - 8OH C19 H16 N4 S c1ccc(cc1)....
149 3IW8 Kd = 13.4 uM HIZ C19 H18 Cl F N4 O2 S c1ccc(cc1)....
150 3TTI ic50 = 0.006 uM KBI C21 H23 F3 N6 O2 c1c(cc(c(c....
151 3TTJ ic50 = 0.21 uM JBI C23 H23 F N6 O COc1ccc(cc....
152 1JNK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
153 4H3B Kd = 17.2 uM VAL VAL ARG PRO GLY SER LEU ASP LEU PRO n/a n/a
154 3KVX ic50 = 0.148 uM FMY C26 H27 F N8 O2 c1cc(ccc1/....
155 4H39 Kd = 0.8 uM PRO LYS ARG PRO THR THR LEU ASN LEU PHE n/a n/a
156 4AWI ic50 = 1 uM AQ2 C21 H25 N3 O4 S2 CC(C)c1cc2....
157 2O0U ic50 = 3.2 uM C0M C27 H28 N4 O2 S c1ccc2c(c1....
158 2P33 ic50 = 57 nM J07 C20 H23 Cl N6 O CCNC(=O)N1....
159 2ZDU - 446 C28 H23 Br N2 O6 COC(=O)C1=....
160 2B1P ic50 = 3 nM AIZ C26 H26 Cl N5 O3 CN(C)CCCC(....
161 2OK1 Ki = 0.55 uM 33A C21 H17 Cl N4 O c1ccc(cc1)....
162 3OXI ic50 = 2.2 uM SYY C12 H11 N O3 S2 COC(=O)c1c....
163 3OY1 ic50 = 0.016 uM 589 C28 H31 N5 O2 c1ccc2cc(c....
164 2ZDT - 46C C26 H20 Cl N O4 CCC(=O)C1=....
165 3ELJ - GS7 C22 H21 F N6 O4 S COc1cc(ccc....
166 3FI2 ic50 = 0.025 uM JK1 C26 H25 N5 O5 COc1cc(cc(....
167 4L7F ic50 = 160 nM 1V5 C26 H26 F N5 O2 c1cc(ccc1C....
168 2WAJ ic50 = 0.398 uM SNB C16 H13 Br Cl N O COc1cc2c(c....
169 4QTD ic50 = 1080 nM 38Z C33 H33 N9 O2 c1cnc(nc1)....
170 3G9L Ki = 0.74 uM J67 C25 H19 F N2 O4 c1ccc(cc1)....
171 4Y46 ic50 = 11 nM 4F2 C22 H32 N6 O2 CC(C)NC(=O....
172 1PMN ic50 = 7.1 nM 984 C25 H30 Cl2 N6 CCCn1c(c(n....
173 3FI3 ic50 = 12 nM JK2 C29 H25 F N4 O4 COc1cc(cc(....
174 2O2U ic50 = 4 uM 738 C16 H13 F N2 O S c1ccc(c(c1....
175 4W4V ic50 = 866 nM 3H8 C23 H19 Cl N6 O2 Cc1cc(ccn1....
176 3DA6 - BZ9 C28 H23 N7 O Cc1cc(c2cc....
177 2R9S ic50 = 0.15 uM 255 C24 H24 N4 O2 S CC(C)(C)NS....
178 4Y5H ic50 = 15 nM 519 C20 H30 N6 O2 CC(C)NC(=O....
179 4X21 Kd = 36 nM 3WH C20 H23 I N6 O CCNC(=O)N1....
180 3RTP ic50 = 7 nM 34I C18 H14 N6 O2 S c1ccc2c(c1....
181 3PZE - CFK C12 H11 N3 O2 S c1ccc(cc1)....
182 4Z9L ic50 = 1.6 nM 880 C27 H34 Cl2 N6 CCCn1c(c(n....
183 4WHZ ic50 < 1 nM 3NL C24 H23 Cl N8 O2 c1ccc(c(c1....
184 4W4Y ic50 = 3034 nM 3HQ C24 H22 N6 O2 Cc1ccc(cc1....
185 4W4W ic50 = 6630 nM 3HJ C23 H20 N6 O2 Cc1cc(ccn1....
186 3G90 Ki = 0.44 uM J72 C17 H12 F2 N2 O4 c1cc2c(cc1....
187 1PMV ic50 = 150 nM 537 C14 H8 N2 O c1ccc2c(c1....
188 3GC8 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
189 3GC9 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
190 4ZSL - 4QZ C17 H17 Cl N6 O C[C@@H](c1....
191 5BYZ ic50 = 0.042 uM 4WE C25 H32 F N7 O Cc1ncc(n1C....
192 4ZSJ ic50 = 2.3 uM 4R0 C13 H17 Cl N6 O Cc1cc(ccc1....
193 4ZSG - 4QX C12 H15 Cl N6 O CC(C)NC(=O....
194 4XP3 - DX4 C5 H5 N5 S c1[nH]c2c(....
195 4O6E ic50 = 1 nM 2SH C21 H25 Cl F N5 O3 c1cc(c(cc1....
196 5NHJ ic50 < 0.0003 uM 8XE C18 H21 N7 O2 Cn1c(ccn1)....
197 4QYY Kd = 0.05 uM 3G7 C25 H29 Cl N4 O4 CC(=O)c1cc....
198 4I5H Ki < 2 nM G17 C26 H21 F3 N4 O Cc1ccc(cc1....
199 4QTE Kd = 0.084 uM 390 C24 H20 Cl2 F N5 O2 Cc1cnc(nc1....
200 4XNE - TT4 C8 H9 N5 c1ccc(cc1)....
201 3QYW - 6PB C11 H8 Br N5 c1cc(cc(c1....
202 5BUE ic50 = 0.003 uM 4V8 C23 H21 N5 O c1ccc(cc1)....
203 2Z7L - S91 C20 H19 N5 O3 Cc1cccc(c1....
204 4ZXT - CAQ C6 H6 O2 c1ccc(c(c1....
205 1WZY ic50 = 0.56 uM F29 C21 H17 N7 C=CCn1c2c(....
206 5NHH ic50 < 0.00113 uM 8XH C19 H25 N5 O3 COCCN1CCc2....
207 4N4S - 2H1 C25 H24 N6 O Cc1cc(cc2c....
208 4QP8 ic50 = 0.28 uM 362 C14 H10 N6 c1cc(cnc1)....
209 4QP4 - 36O C11 H15 N5 c1[nH]c2c(....
210 4QP9 ic50 = 0.071 uM 35X C17 H16 N6 CCCn1cc(cn....
211 5BVE ic50 = 0.01 nM 4VG C25 H28 Cl N5 O3 c1cc(cc(c1....
212 5KE0 - 6S9 C20 H18 N6 O Cc1cc(ccn1....
213 4XOY - DX4 C5 H5 N5 S c1[nH]c2c(....
214 3QYZ - Z8B C10 H11 Br N8 O3 c1nc(c2c(n....
215 5BVF ic50 = 0.19 nM 4VJ C25 H28 Cl N5 O3 c1cc(cc(c1....
216 4XOZ - 620 C15 H16 N6 O c1ccc(cc1)....
217 5HD7 - 38Z C33 H33 N9 O2 c1cnc(nc1)....
218 4XRJ - 620 C15 H16 N6 O c1ccc(cc1)....
219 2OJJ Ki = 0.002 uM 82A C22 H17 Cl2 F N4 O2 c1cc(cc(c1....
220 4QTA Kd = 0.013 uM 38Z C33 H33 N9 O2 c1cnc(nc1)....
221 5NHO ic50 < 0.0003 uM 8XN C20 H25 N7 O2 Cc1cnc(nc1....
222 2OJG Ki = 2.3 uM 19A C16 H16 N4 O CN(C)C(=O)....
223 4XP0 - 42A C8 H5 N3 c1cc2c(c[n....
224 4QP2 Kd = 940 uM 36R C7 H5 Cl N2 O c1cc2c(cc1....
225 5NHF ic50 = 0.0012 uM 8X5 C23 H25 N5 O2 c1ccc(cc1)....
226 5BUJ ic50 = 0.005 uM 4VB C16 H15 N5 O c1cnccc1c2....
227 5BUI ic50 = 0.089 uM 4V9 C17 H15 F N4 c1ccnc(c1)....
228 4QP7 ic50 = 5.9 uM 363 C9 H7 N5 c1c[nH]c2c....
229 3ERK ic50 = 18 uM SB4 C18 H19 F N6 c1cc(ccc1c....
230 5V60 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
231 1TVO Ki = 0.14 uM FRZ C18 H13 N7 c1ccc(cc1)....
232 5BVD ic50 = 0.16 nM 4VF C24 H26 Cl N5 O3 c1cc(cc(c1....
233 4ZZN ic50 = 0.26 uM CQ8 C18 H21 Cl N4 O2 CNC(=O)c1c....
234 3SA0 - NRA C13 H8 O6 c1c(cc2c(c....
235 4ERK ic50 = 27 uM OLO C15 H18 N6 O Cn1cnc2c1n....
236 5U6I - 81Y C19 H22 N4 O2 CC(C)Oc1cc....
237 5NHV ic50 = 0.0028 uM 8QB C16 H19 N5 O2 c1cnc(nc1c....
238 3I5Z Ki = 2 nM Z48 C24 H23 N5 O2 Cc1cnc(nc1....
239 4N0S - DHC C9 H8 O4 c1cc(c(cc1....
240 5NHP ic50 = 0.023 uM 8XK C19 H23 N7 O2 Cn1c(ccn1)....
241 3I60 Ki < 2 nM E86 C24 H22 Cl N5 O2 Cc1cnc(nc1....
242 4XP2 - TT4 C8 H9 N5 c1ccc(cc1)....
243 1PME Ki = 0.76 nM SB2 C21 H16 F N3 O S C[S@](=O)c....
244 5NHL ic50 < 0.0003 uM 8XB C20 H25 N7 O2 Cc1cnc(nc1....
245 5HD4 - 38Z C33 H33 N9 O2 c1cnc(nc1)....
246 5K4I ic50 = 3.1 nM 6QB C21 H18 Cl F N6 O2 Cn1c(ccn1)....
247 2F9G - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
248 2B9F - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
249 5AWM - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
250 4EYM - 0RX C21 H20 N4 O3 c1cc(ccc1N....
251 5EKO ic50 = 15785 nM N17 C22 H18 N4 O2 Cc1cn(cn1)....
252 4EYJ - N61 C20 H23 N5 O2 CC(C)(C)c1....
253 1CM8 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
254 4QTB Kd = 0.084 uM 38Z C33 H33 N9 O2 c1cnc(nc1)....
255 2ZOQ ic50 = 0.9 uM 5ID C11 H13 I N4 O4 c1c(c2c(nc....
256 3NPC - B96 C31 H37 N5 O3 Cc1ccc(cc1....
257 3E7O ic50 = 120 nM 35F C20 H14 N6 O2 c1cc(cc(c1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ANP; Similar ligands found: 358
No: Ligand ECFP6 Tc MDL keys Tc
1 ANP 1 1
2 A2D 0.810811 0.945205
3 B4P 0.802632 0.945205
4 ADP 0.802632 0.972222
5 AP5 0.802632 0.945205
6 BA3 0.789474 0.945205
7 AU1 0.782051 1
8 ATP 0.772152 0.972222
9 AN2 0.769231 0.986111
10 AQP 0.7625 0.972222
11 5FA 0.7625 0.972222
12 M33 0.759494 0.932432
13 MAP 0.752941 0.972973
14 ACP 0.75 0.945946
15 APR 0.740741 0.945205
16 AR6 0.740741 0.945205
17 ACQ 0.73494 0.945946
18 AD9 0.731707 0.945946
19 SAP 0.731707 0.921053
20 AGS 0.731707 0.921053
21 AMP 0.723684 0.944444
22 A 0.723684 0.944444
23 ATF 0.717647 0.933333
24 ADX 0.716049 0.851852
25 CA0 0.716049 0.92
26 50T 0.707317 0.932432
27 PRX 0.698795 0.87013
28 ABM 0.696203 0.893333
29 AMP MG 0.683544 0.868421
30 AP2 0.679012 0.933333
31 A12 0.679012 0.933333
32 APC 0.678571 0.933333
33 TAT 0.674419 0.933333
34 A22 0.674157 0.958904
35 SRA 0.670886 0.894737
36 SRP 0.670455 0.883117
37 5AL 0.666667 0.906667
38 ADQ 0.659341 0.92
39 A1R 0.659341 0.884615
40 ADP MG 0.654762 0.881579
41 3OD 0.648936 0.92
42 BIS 0.648936 0.909091
43 5SV 0.648352 0.82716
44 BEF ADP 0.647059 0.858974
45 ADP BEF 0.647059 0.858974
46 OAD 0.645161 0.92
47 25L 0.642105 0.958904
48 AMO 0.641304 0.907895
49 G5P 0.636364 0.897436
50 DLL 0.634409 0.906667
51 AHX 0.634409 0.897436
52 00A 0.634409 0.860759
53 ANP MG 0.633333 0.921053
54 ADV 0.632184 0.907895
55 ADP PO3 0.632184 0.917808
56 RBY 0.632184 0.907895
57 NB8 0.631579 0.897436
58 25A 0.630435 0.945205
59 8QN 0.630435 0.906667
60 OOB 0.630435 0.906667
61 G3A 0.626263 0.897436
62 ATP MG 0.625 0.881579
63 4AD 0.623656 0.896104
64 PAJ 0.623656 0.8625
65 LAD 0.621053 0.839506
66 1ZZ 0.614583 0.819277
67 TXA 0.614583 0.907895
68 ME8 0.614583 0.819277
69 GTA 0.613861 0.864198
70 3UK 0.610526 0.894737
71 SON 0.604651 0.907895
72 ADP ALF 0.604396 0.848101
73 ALF ADP 0.604396 0.848101
74 WAQ 0.604167 0.860759
75 PR8 0.604167 0.829268
76 4UV 0.6 0.871795
77 GAP 0.6 0.87013
78 FYA 0.597938 0.881579
79 PTJ 0.597938 0.873418
80 ADP VO4 0.597826 0.906667
81 VO4 ADP 0.597826 0.906667
82 UP5 0.596154 0.896104
83 YAP 0.59596 0.871795
84 FA5 0.59596 0.883117
85 PAP 0.595506 0.958333
86 A4P 0.59434 0.823529
87 XAH 0.59 0.841463
88 4UU 0.588235 0.871795
89 AFH 0.588235 0.8625
90 9SN 0.585859 0.85
91 2A5 0.58427 0.894737
92 T5A 0.583333 0.821429
93 NAI 0.580952 0.884615
94 ITT 0.579545 0.917808
95 ATR 0.577778 0.944444
96 OMR 0.575472 0.831325
97 5AS 0.574713 0.781609
98 YLP 0.571429 0.8
99 48N 0.571429 0.873418
100 AP0 0.570093 0.873418
101 4TC 0.570093 0.873418
102 7D3 0.569767 0.881579
103 ADJ 0.568807 0.831325
104 GNP 0.568421 0.922078
105 DAL AMP 0.568421 0.881579
106 NXX 0.566038 0.907895
107 TXD 0.566038 0.884615
108 NAX 0.566038 0.851852
109 4UW 0.566038 0.839506
110 6V0 0.566038 0.873418
111 DND 0.566038 0.907895
112 XYA 0.565789 0.821918
113 ADN 0.565789 0.821918
114 RAB 0.565789 0.821918
115 AOC 0.564706 0.8
116 7D4 0.561798 0.881579
117 ADP BMA 0.561224 0.894737
118 TXE 0.560748 0.884615
119 TYM 0.560748 0.883117
120 YLB 0.555556 0.8
121 YLC 0.555556 0.819277
122 139 0.554545 0.851852
123 5N5 0.551282 0.797297
124 JB6 0.55 0.860759
125 LAQ 0.54717 0.819277
126 MYR AMP 0.544554 0.797619
127 A4D 0.544304 0.797297
128 5CD 0.544304 0.783784
129 7MD 0.542857 0.864198
130 6AD 0.542553 0.886076
131 A2R 0.541667 0.958904
132 UPA 0.541284 0.884615
133 YLA 0.540541 0.8
134 A A 0.54 0.918919
135 COD 0.539823 0.793103
136 BTX 0.539823 0.821429
137 G5A 0.537634 0.781609
138 CNA 0.535714 0.907895
139 AYB 0.535714 0.790698
140 3DH 0.535714 0.753247
141 BT5 0.535088 0.811765
142 ATP A A A 0.533981 0.905405
143 IOT 0.531532 0.811765
144 MTA 0.53012 0.753247
145 3AM 0.529412 0.90411
146 A3P 0.52809 0.944444
147 NAD 0.526316 0.906667
148 PPS 0.526316 0.851852
149 EP4 0.52439 0.734177
150 7D5 0.52381 0.855263
151 AMP DBH 0.52381 0.87013
152 J7C 0.522727 0.75
153 A5A 0.520833 0.809524
154 EAD 0.520661 0.851852
155 TSB 0.520408 0.821429
156 AHZ 0.518519 0.797619
157 M2T 0.518072 0.716049
158 DTA 0.518072 0.766234
159 A3D 0.517241 0.894737
160 6RE 0.517241 0.740741
161 YLY 0.516949 0.790698
162 SSA 0.515464 0.802326
163 NA7 0.514852 0.933333
164 TYR AMP 0.514286 0.858974
165 AR6 AR6 0.514019 0.893333
166 7MC 0.513514 0.843373
167 A2P 0.511111 0.930556
168 52H 0.510204 0.781609
169 VMS 0.510204 0.790698
170 54H 0.510204 0.790698
171 TAD 0.509259 0.8625
172 NAQ 0.508333 0.85
173 A3N 0.505618 0.766234
174 AV2 0.505155 0.893333
175 5CA 0.50505 0.802326
176 53H 0.50505 0.781609
177 ARU 0.504951 0.839506
178 ARG AMP 0.504587 0.809524
179 ZID 0.504132 0.894737
180 P1H 0.504 0.831325
181 3AT 0.5 0.945205
182 NAE 0.5 0.871795
183 AVV 0.5 0.873418
184 P5A 0.495146 0.747253
185 DSZ 0.49505 0.802326
186 LSS 0.49505 0.764045
187 NSS 0.49505 0.802326
188 N0B 0.491803 0.8
189 AF3 ADP 3PG 0.491071 0.817073
190 LA8 ALF 3PG 0.491071 0.817073
191 ALF ADP 3PG 0.491071 0.817073
192 NVA LMS 0.490196 0.764045
193 DAT 0.489362 0.881579
194 IMO 0.488889 0.90411
195 ZAS 0.488636 0.792208
196 FDA 0.488372 0.813953
197 NAJ PZO 0.487395 0.85
198 4TA 0.487179 0.788235
199 LPA AMP 0.486486 0.797619
200 LEU LMS 0.485437 0.764045
201 DTP 0.484536 0.881579
202 V3L 0.484536 0.945205
203 GJV 0.483516 0.731707
204 S4M 0.483516 0.651685
205 DZD 0.483051 0.8625
206 2AM 0.482759 0.917808
207 5AD 0.481013 0.726027
208 KAA 0.480769 0.755556
209 GSU 0.480769 0.781609
210 NDE 0.480315 0.907895
211 M24 0.479339 0.851852
212 MAO 0.478261 0.761905
213 DSH 0.477778 0.707317
214 NEC 0.477778 0.727273
215 FAD 0.477273 0.831325
216 FAS 0.477273 0.831325
217 RGT 0.476636 0.933333
218 0WD 0.474576 0.897436
219 G A A A 0.474576 0.85
220 FNK 0.474074 0.786517
221 5X8 0.473684 0.74359
222 6FA 0.473282 0.821429
223 FB0 0.472868 0.786517
224 NDC 0.472868 0.85
225 YSA 0.472222 0.781609
226 7DD 0.468085 0.958333
227 OVE 0.466667 0.881579
228 NAD IBO 0.466102 0.848101
229 MHZ 0.463158 0.701149
230 A3G 0.461538 0.779221
231 6C6 0.459184 0.858974
232 U A G G 0.458333 0.860759
233 SFG 0.458333 0.730769
234 7D7 0.45679 0.723684
235 128 0.45614 0.8
236 SFD 0.455224 0.736842
237 DDS 0.454545 0.855263
238 GDP 0.454545 0.896104
239 6IA 0.454545 0.817073
240 NJP 0.453782 0.921053
241 ODP 0.453782 0.886076
242 7DT 0.453608 0.958333
243 A7D 0.452632 0.75641
244 Z5A 0.452381 0.802326
245 WSA 0.452174 0.790698
246 7C5 0.45045 0.797468
247 FAY 0.449275 0.841463
248 NDP 0.449153 0.897436
249 A5D 0.44898 0.766234
250 SA8 0.44898 0.690476
251 NAJ PYZ 0.448 0.851852
252 71V 0.446809 0.884615
253 GGZ 0.446602 0.804878
254 RFL 0.446043 0.802326
255 2SA 0.445545 0.907895
256 AMP NAD 0.444444 0.858974
257 GP3 0.444444 0.897436
258 SAI 0.444444 0.716049
259 SAH 0.444444 0.725
260 A A A 0.443396 0.881579
261 PO4 PO4 A A A A PO4 0.443396 0.878378
262 4YB 0.442478 0.764045
263 GTP 0.441176 0.896104
264 SMM 0.441176 0.670455
265 S7M 0.441176 0.674419
266 Y3J 0.440476 0.706667
267 SAM 0.44 0.674419
268 649 0.439655 0.747253
269 12D 0.438596 0.809524
270 A3S 0.4375 0.789474
271 NPW 0.436975 0.864198
272 GCP 0.436893 0.873418
273 AAT 0.435644 0.690476
274 EEM 0.435644 0.674419
275 GNH 0.435644 0.909091
276 DCA 0.435484 0.804598
277 ETB 0.435484 0.813953
278 N6P 0.433962 0.890411
279 TXP 0.433333 0.897436
280 NZQ 0.433333 0.886076
281 PGS 0.43299 0.860759
282 APU 0.432203 0.871795
283 PUA 0.432 0.8625
284 62F 0.431655 0.841463
285 F2N 0.431507 0.795455
286 DA 0.430108 0.855263
287 D5M 0.430108 0.855263
288 J7V 0.429688 0.813953
289 NIA 0.428571 0.848101
290 6K6 0.428571 0.905405
291 A3T 0.428571 0.8
292 0T1 0.428571 0.804598
293 COA 0.428571 0.804598
294 P5F 0.427586 0.804598
295 AAM 0.425532 0.944444
296 0UM 0.424528 0.682353
297 G1R 0.423077 0.884615
298 AMZ 0.422222 0.891892
299 C2R 0.422222 0.88
300 A U 0.420168 0.848101
301 IDP 0.42 0.894737
302 GSP 0.419048 0.851852
303 COS 0.418605 0.786517
304 CAO 0.418605 0.777778
305 AMX 0.418605 0.813953
306 30N 0.418605 0.736842
307 DG1 0.418605 0.897436
308 1DG 0.418605 0.897436
309 TM1 0.418182 0.797619
310 A6D 0.416667 0.746988
311 K15 0.416667 0.666667
312 V1N 0.415929 0.893333
313 SCO 0.415385 0.804598
314 CMX 0.415385 0.804598
315 GEK 0.415094 0.719512
316 NHD 0.414634 0.881579
317 XNP 0.414634 0.851852
318 AIR 0.413793 0.876712
319 COK 0.413534 0.786517
320 G2R 0.412844 0.8625
321 FCX 0.412214 0.777778
322 FAM 0.412214 0.786517
323 ACO 0.412214 0.777778
324 NAP 0.410853 0.92
325 CNV FAD 0.409722 0.775281
326 FA9 0.409396 0.843373
327 SXZ 0.409091 0.694118
328 HAX 0.409091 0.806818
329 PLP AAD 0.408 0.744444
330 TAP 0.407692 0.884615
331 2MC 0.407407 0.752688
332 62X 0.407407 0.651685
333 GKE 0.40708 0.8625
334 GDD 0.40708 0.8625
335 GDC 0.40708 0.8625
336 FYN 0.406015 0.804598
337 3KK 0.406015 0.786517
338 U G A 0.405797 0.819277
339 NA0 0.40458 0.907895
340 101 0.404255 0.855263
341 G 0.40404 0.883117
342 5GP 0.40404 0.883117
343 MGP 0.403846 0.8625
344 MCD 0.402985 0.786517
345 OXK 0.402985 0.786517
346 CA6 0.402985 0.714286
347 SOP 0.402985 0.786517
348 3AD 0.402299 0.783784
349 S8M 0.401869 0.78481
350 YE1 0.40146 0.795455
351 1VU 0.4 0.777778
352 2VA 0.4 0.779221
353 CMC 0.4 0.786517
354 7RP 0.4 0.902778
355 GMV 0.4 0.873418
356 6G0 0.4 0.8625
357 CO6 0.4 0.786517
358 NMX 0.4 0.782609
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5AWM; Ligand: ANP; Similar sites found: 370
This union binding pocket(no: 1) in the query (biounit: 5awm.bio1) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2RIF AMP 0.005768 0.41717 None
2 3DNT ATP 0.0008688 0.47098 1.26904
3 3ETH ATP 0.002544 0.44446 1.40845
4 5I35 ANP 0.00002388 0.53285 1.52672
5 5C1P DAL DAL 0.001065 0.46839 1.63399
6 5C1P ADP 0.0004406 0.46736 1.63399
7 2E5A LAQ 0.0245 0.40489 1.72911
8 5BV3 M7G 0.007279 0.41854 1.73913
9 1PK8 ATP 0.00002322 0.432 1.77665
10 4UWH JXM 0.003624 0.42674 1.77665
11 1OX5 1PR 0.01893 0.41056 1.77665
12 4RDL FUC GAL NDG FUC 0.003312 0.40196 1.94805
13 2Q7D ANP 0.00779 0.42713 2.02312
14 5MW8 ATP 0.0003303 0.4897 2.03046
15 2Z49 AMG 0.002734 0.44849 2.03046
16 1TZD ADP 0.0005406 0.41277 2.03046
17 2YW2 ATP 0.001163 0.40211 2.03046
18 5U98 1KX 0.0164 0.4259 2.16606
19 4XYM A12 0.0006806 0.46819 2.17391
20 2IF8 ADP 0.0001932 0.46537 2.20386
21 2PYW ADP 0.00002928 0.53652 2.28426
22 5TT5 NAD 0.001878 0.45622 2.28426
23 3F3E LEU 0.03611 0.40605 2.28426
24 5GZ9 ANP 0.00000004116 0.68079 2.29508
25 5IQD GNP 0.002083 0.46803 2.29508
26 5IQD RIO 0.002196 0.46803 2.29508
27 3LLI FAD 0.01839 0.40987 2.29885
28 2FB3 GTP 0.02954 0.40201 2.35294
29 2FB3 5AD 0.01242 0.40135 2.35294
30 3TII ANP 0.002066 0.43321 2.36842
31 1S68 AMP 0.005753 0.40333 2.40964
32 3AKK ADP 0.002955 0.43745 2.46154
33 3LOO B4P 0.02029 0.41713 2.46575
34 2V58 LZJ 0.0005927 0.50425 2.53807
35 1M0W ANP 0.001644 0.44299 2.53807
36 4U98 ACP 0.003377 0.40222 2.53807
37 1I7L ATP 0.00007834 0.52238 2.589
38 1IOW PHY 0.001424 0.47399 2.61438
39 1IOW ADP 0.001424 0.47399 2.61438
40 4IRX INS 0.007585 0.40683 2.7027
41 2VPQ ANP 0.0001322 0.50915 2.79188
42 3DLG GWE 0.04561 0.41627 2.79188
43 3T1A 5MA 0.01147 0.40899 2.79188
44 4FMU 0UM 0.01996 0.40231 2.79188
45 4CC6 L5Y 0.0005049 0.45465 2.83019
46 3VPC ADP 0.00004413 0.44298 2.83688
47 3V4S ATP 0.009394 0.41676 2.84238
48 4EN4 GT1 0.02819 0.4117 2.88462
49 4EN4 GT0 0.02819 0.4117 2.88462
50 4EN4 ATP 0.02819 0.4117 2.88462
51 1JG3 ADN 0.01456 0.41761 2.97872
52 5VZ0 ADP 0.0001298 0.49785 3.04569
53 3KAL ADP 0.001215 0.47617 3.04569
54 3K5I ADP 0.01403 0.40652 3.04569
55 3K5I AIR 0.02938 0.40448 3.04569
56 4A4Z ANP 0.01006 0.4011 3.04569
57 5USZ SKE 0.0000009418 0.62387 3.11419
58 3X01 AMP 0.0007341 0.46905 3.30789
59 3OOI SAM 0.01042 0.41283 3.44828
60 3WVR AMP 0.001321 0.44749 3.5533
61 4B0T ADP 0.01846 0.407 3.5533
62 4O4F ATP 0.001455 0.46169 3.62903
63 4O4F IHP 0.001572 0.46169 3.62903
64 4DFU QUE 0.005994 0.42122 3.72671
65 4WOV 3SM 0.00003914 0.50226 3.78549
66 2CFM AMP 0.001861 0.43533 3.80711
67 4GLW 0XT 0.0004886 0.45517 3.93443
68 3HY3 10F 0.007312 0.42542 3.94089
69 2IVF MD1 0.01692 0.42014 3.97727
70 2PUL ACP 0.007463 0.4417 4.06091
71 5DZT AMP 0.002957 0.40917 4.06091
72 4LCN GNG 0.01018 0.40323 4.06091
73 2GUE NAG 0.01978 0.40021 4.09836
74 4JBL MET 0.009614 0.41109 4.12979
75 4CS9 AMP 0.009765 0.40968 4.2328
76 3VOT ADP 0.0002244 0.47816 4.31472
77 3I0O ADP 0.0002341 0.47731 4.42478
78 2QK4 ATP 0.0007331 0.44798 4.56853
79 1T36 ADP 0.004465 0.44066 4.56853
80 2GQR ADP 0.007713 0.41334 4.64135
81 1IA9 ANP 0.0000468 0.4593 4.64286
82 5W2I ADP 0.0001975 0.50263 4.66926
83 5W2I I3P 0.0001975 0.50263 4.66926
84 5ENQ 5QE 0.005094 0.43477 4.73373
85 1W2D ADP 0.0005101 0.46154 4.90566
86 3RE4 TO1 0.00007103 0.50145 5.03876
87 4OUC 5ID 0.0000007727 0.60037 5.04202
88 4MV1 ADP 0.0009972 0.47914 5.07614
89 5DXT 5H5 0.003086 0.43654 5.07614
90 2AQX ATP 0.0006177 0.4096 5.19031
91 3TDV GDP 0.002245 0.40765 5.22876
92 4OCJ NDG 0.00025 0.51658 5.27704
93 3UDZ ADP 0.00008943 0.51066 5.32995
94 5FI4 5XV 0.008186 0.423 5.32995
95 3KH5 AMP 0.02438 0.42438 5.35714
96 4O1P ANP 0.00000005266 0.66286 5.58376
97 4CYI ATP 0.00001102 0.55707 5.58376
98 2VQD AP2 0.0004459 0.42033 5.58376
99 5K2M ADP 0.00005934 0.52831 5.66038
100 3PN1 IVH 0.0005508 0.44396 5.66038
101 2R3A SAM 0.008471 0.41343 5.66667
102 3HAV ATP 0.0001899 0.45609 5.68562
103 5CKW ANP 0.00003479 0.5159 5.83756
104 3TY5 ATP 0.003396 0.42314 5.83756
105 3TY5 ADP 0.01049 0.40485 5.83756
106 4R38 RBF 0.01152 0.41071 6.42857
107 5COU ATP 0.002863 0.43388 6.47059
108 4R78 AMP 0.000004354 0.56653 6.47249
109 4C5N ACP 0.0002722 0.40338 6.52174
110 4GYI ADP 0.00000997 0.52869 6.59898
111 4KOT CE3 0.03437 0.40718 6.79012
112 2BKK ADP 0.0003096 0.47455 6.81818
113 4LH7 1X8 0.000172 0.50908 7.12074
114 1CKN GTP 0.003817 0.41649 7.27273
115 1CKM GTP 0.01016 0.40524 7.27273
116 3CH6 311 0.04642 0.41138 7.34266
117 3CH6 NAP 0.04642 0.41138 7.34266
118 5TDF ADP 0.0008819 0.46488 7.36041
119 5ML3 DL3 0.01828 0.4205 7.38255
120 2GQS ADP 0.005705 0.41959 7.59494
121 4P8K 38C 0.03461 0.41692 7.61421
122 4P8K FAD 0.03461 0.41692 7.61421
123 2IO8 ADP 0.0001758 0.40968 7.61421
124 4ZGP ADP 0.006803 0.41594 8.19113
125 4OCV ANP 0.0002461 0.43874 8.44327
126 4CNG SAH 0.008114 0.42769 8.62745
127 4AZW ATP 0.001136 0.45956 8.62944
128 4AZT LY2 0.000606 0.45805 8.62944
129 3ORQ ADP 0.004799 0.42919 8.75332
130 4WW7 AMP 0.000109 0.51111 9.62567
131 1IDA 0PO 0.03398 0.40549 10.101
132 3VPB ADP 0.00004607 0.53578 10.7143
133 5C03 AGS 0.00001181 0.55027 10.9137
134 4RYV ZEA 0.009379 0.40251 12.9032
135 4OH4 ANP 0.00000002696 0.67679 12.9129
136 4LRJ ANP 0.00001112 0.54864 13.0178
137 3UIM ANP 0.000000007077 0.61136 13.4969
138 4IX4 ADP 0.00006264 0.52052 13.7143
139 5SVV FMN 0.01208 0.40969 13.8686
140 3PP0 03Q 0.0000000004208 0.55047 13.9053
141 3VHE 42Q 0.00000008159 0.46949 13.9276
142 1ZTH ADP 0.000008744 0.54385 13.9535
143 1ZP9 ATP 0.00001714 0.50555 13.9535
144 2PZI AXX 0.00002564 0.50965 14.2132
145 5LPB ADP 0.00000004727 0.64952 14.527
146 3Q60 ATP 0.00003344 0.52589 14.5553
147 1NVM NAD 0.02228 0.41065 14.7436
148 3PVW QRX 0.00006326 0.42317 14.9746
149 4BKJ STI 0.000009108 0.57056 15.2381
150 4ZS4 ATP 0.0001033 0.44437 15.3094
151 5C4L 4XR 0.001827 0.46445 15.5763
152 5C4L SIS 0.0158 0.41706 15.5763
153 2X2M X2M 0.0000002325 0.64119 16.242
154 1TQP ATP 0.0001745 0.41401 17.0213
155 3PDT ADP 0.0005666 0.46488 17.0909
156 5DMZ ADP 0.000001444 0.53202 17.2603
157 3GNI ATP 0.0000001973 0.64171 17.4807
158 5T8O 76Z 0.000000001484 0.60595 20.3438
159 4OAV ACP 0.00000008597 0.58849 20.8122
160 4FL3 ANP 0.0000009223 0.61204 21.066
161 5VC5 96M 0.000001176 0.61906 22.4914
162 4OTH DRN 0.000001003 0.61027 22.8739
163 2H8H H8H 0.00000002693 0.67681 23.3503
164 4Y0X ADP 0.00001798 0.53574 24
165 4Y93 746 0.000007621 0.57439 24.3655
166 5MJA 7O3 0.0000005361 0.60788 24.5902
167 4WNK 453 0.000012 0.57267 24.6193
168 4BTK DTQ 0.000005002 0.56815 25.2226
169 4F9C 0SX 0.00000000156 0.73205 25.7618
170 3V8S 0HD 0.0000005166 0.6121 25.8883
171 4DC2 ADE 0.0000001084 0.56769 26.1421
172 5UKL SIX 0.00006431 0.53247 26.3959
173 4IDT T28 0.000000007733 0.69895 26.4045
174 5TA6 79D 0.00001657 0.42322 26.5363
175 5LI1 ANP 0.000000011 0.70572 26.5537
176 5HCY 60D 0.0000002032 0.68391 26.5861
177 3MVH WFE 0.0000004372 0.64491 26.6082
178 5LI9 ACP 0.00001026 0.48458 26.8571
179 2RIO ADP 0.00000001101 0.69165 26.9036
180 5VCV 1N1 0.00000006946 0.51882 27.0096
181 4E93 GUI 0.00000002965 0.47312 27.0557
182 2R5T ANP 0.0000005425 0.51461 27.0777
183 4XH0 ADP 0.00000005715 0.67537 27.1574
184 5LPZ ADP 0.00000007827 0.65462 27.4096
185 1Y57 MPZ 0.000001335 0.4849 27.4112
186 4NFN 2KC 0.00000955 0.55179 27.5081
187 3TXO 07U 0.0000001629 0.63234 28.0453
188 4Q5H ANP 0.0005213 0.4715 28.1609
189 4N70 2HX 0.000005 0.61664 28.3537
190 3FC2 IBI 0.01522 0.44433 28.3582
191 3VRY B43 0.000001013 0.47103 28.4264
192 4G17 0VN 0.000001578 0.58571 28.4848
193 2Y6O 1N1 0.000001991 0.59577 28.5223
194 4PZ6 GMP 0.00004339 0.46803 28.5714
195 4U44 3D9 0.0000005241 0.61507 28.6145
196 2OO8 RAJ 0.0001605 0.50293 28.7066
197 1U5R ATP 0.00000001729 0.59797 28.7356
198 3H9R TAK 0.0000006381 0.60644 28.7879
199 4FF8 14S 0.00001567 0.53204 28.7926
200 2XVD AS6 0.000001665 0.61368 28.8079
201 4Y8D 49J 0.00000004137 0.58089 28.8235
202 5HVJ ANP 0.000005758 0.5729 28.8889
203 4BHN BH9 0.00000005035 0.67044 29.0419
204 4X7Q 3YR 0.0000000816 0.57671 29.1667
205 3DLS ADP 0.000000003462 0.71143 29.2537
206 3CY2 MB9 0.000001088 0.49914 29.6178
207 4I94 ANP 0.00000005427 0.65867 29.6667
208 3TKI S25 0.000001042 0.65771 29.7214
209 1JPA ANP 0.0000001055 0.47056 29.8077
210 2HY0 306 0.000002884 0.55109 29.8137
211 4JR7 GNP 0.0000000164 0.68713 29.9465
212 4L9I 8PR 0.00007087 0.51036 29.9492
213 4ASE AV9 0.0000002769 0.65037 30.0283
214 5TO8 7FM 0.000003418 0.61404 30.1418
215 4K33 ACP 0.0000003188 0.62859 30.1538
216 5JGA 6KC 0.0000004765 0.44426 30.1587
217 4WB7 ATP 0.00000007781 0.44659 30.203
218 3KMW ATP 0.00003202 0.52679 30.2326
219 4QMN DB8 0.00001094 0.58335 30.3226
220 3GQI ACP 0.0000001386 0.56615 30.3681
221 5W4W 9WG 0.000006254 0.58877 30.5136
222 4KBA 1QM 0.00002557 0.42037 30.5136
223 1BYG STU 0.00000007055 0.64953 30.5755
224 1OPK P16 0.0000005268 0.4472 30.7107
225 2PVF ACP 0.000000139 0.58202 30.8383
226 5AX9 4KT 0.00000000712 0.70448 30.8442
227 3GGF GVD 0.0000002175 0.6264 30.897
228 4EWH T77 0.0000005585 0.46843 30.9091
229 4E1Z 0MX 0.0000003034 0.50784 30.9278
230 4M69 ANP 0.0000009949 0.60767 30.9904
231 4EUU BX7 0.0000005883 0.47716 31.0345
232 4GJ3 0XP 0.00000008347 0.68328 31.1258
233 4CLI 5P8 0.000001676 0.63612 31.1927
234 3C1X CKK 0.000004445 0.47552 31.2183
235 2CSN CKI 0.002272 0.48349 31.3131
236 4Y85 499 0.000005946 0.56159 31.3253
237 3LXN MI1 0.0000000106 0.57814 31.4465
238 3LXK MI1 0.00000006016 0.6834 31.4985
239 3NW7 LGV 0.00001185 0.5944 31.5961
240 3EKK GS2 0.000001868 0.40891 31.5961
241 3BU5 ATP 0.0000001046 0.64858 31.6993
242 3KRL KRL 0.000009 0.46817 31.9403
243 1K3A ACP 0.0000009394 0.59279 32.4415
244 5UR1 YY9 0.00008063 0.54713 32.4759
245 4YZC STU 0.0000002489 0.66919 32.4873
246 3KRR DQX 0.0000002447 0.70205 32.5424
247 3RI1 3RH 0.0000003452 0.64323 32.5879
248 4P5Z Q7M 0.000006995 0.59647 32.687
249 1U59 STU 0.0000004664 0.55002 32.7526
250 4AT3 LTI 0.0000008568 0.44346 32.7759
251 3PLS ANP 0.0000002491 0.62718 32.8859
252 3ALN ANP 0.00000002251 0.68738 33.0275
253 5JKG 6LF 0.00002994 0.56399 33.119
254 4YMJ 4EJ 0.0000003782 0.63561 33.2237
255 5HX8 66P 0.00000003997 0.5072 33.4437
256 4AG8 AXI 0.0000006357 0.42085 33.5443
257 3SXS PP2 0.0000001709 0.64473 33.5821
258 4USF 6UI 0.00000362 0.58804 33.8816
259 2OFV 242 0.00000007653 0.69351 33.935
260 4U0I 0LI 0.000001376 0.62192 33.9683
261 3FHI ANP 0.00000001959 0.70506 34
262 2QCS ANP 0.00000002378 0.70089 34
263 1RE8 BD2 0.0000001439 0.69485 34
264 3IDB ANP 0.00000001826 0.54737 34
265 4L3L 5FI 0.000001697 0.61533 34.2105
266 3G5D 1N1 0.0000007329 0.66831 34.2657
267 4WB6 ATP 0.00000002865 0.69687 34.2857
268 1VJY 460 0.00000001323 0.72593 34.3234
269 2QLU ADE 0.000009211 0.45908 34.3949
270 5JFS 6K0 0.0000004014 0.66371 34.4156
271 5UIU 8CG 0.00000004521 0.69441 34.6749
272 2Z7R STU 0.00000009536 0.66003 34.891
273 2ZV2 609 0.0000002861 0.61308 34.8993
274 3HZT J60 0.000001918 0.57456 35.0254
275 2YAB AMP 0.00001211 0.55249 35.1801
276 2GU8 796 0.0000002054 0.69781 35.3116
277 4TWP AXI 0.0000003926 0.67051 35.4244
278 5FBN 5WF 0.000009218 0.58551 35.4244
279 4A4X JUP 0.000005797 0.58244 35.4839
280 2HK5 1BM 0.0000002915 0.6335 35.5556
281 4CSV STI 0.000006374 0.57361 35.6364
282 5CEO 50D 0.000002286 0.58443 35.6667
283 5KO1 6UY 0.0000001641 0.6358 35.689
284 3ORK AGS 0.00002285 0.44405 35.6913
285 5UOX 8GY 0.0000000746 0.66523 35.7934
286 2A19 ANP 0.000004047 0.55945 35.9155
287 3IGO ANP 0.000001699 0.49158 36.2944
288 5EOB 5QQ 0.00001188 0.60262 36.3636
289 4WNP 3RJ 0.00000003403 0.63792 36.5854
290 3FHR P4O 0.0000004289 0.53535 36.6071
291 4D2S DYK 0.00000004542 0.65457 36.6197
292 3E8N ATP 0.0000000642 0.4072 36.6569
293 3E8N VRA 0.0000000642 0.4072 36.6569
294 3SXF BK5 0.000005615 0.59648 36.802
295 4YZN 4K5 0.0000000873 0.66481 37.2822
296 5M06 ADP 0.000006608 0.5563 37.3188
297 5HES 032 0.0000001463 0.65099 37.4593
298 5U6C 7YS 0.00000003347 0.68218 37.4603
299 3AQV TAK 0.000173 0.49445 37.6812
300 4NW6 2NS 0.00000001475 0.47809 38.0805
301 4BFM ANP 0.0000001951 0.53747 38.6228
302 4CRL C1I 0.0000001385 0.6764 38.67
303 4XV1 904 0.000003882 0.60289 38.6986
304 3QCQ 3Q0 0.00006882 0.58326 38.7821
305 5LVP ATP 0.00002202 0.52846 38.9068
306 5LXC 7AA 0.00000001605 0.67993 39.0863
307 3M2W L8I 0.0000002015 0.62418 39.7993
308 1ZY5 ANP 0.00002529 0.53166 39.934
309 5DBX ANP 0.00000118 0.58814 39.939
310 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.0000006544 0.67214 40.0585
311 2JDR L20 0.0000006544 0.67214 40.0585
312 2WEL K88 0.00000152 0.53966 40.0612
313 5H2U 1N1 0.0000005183 0.6153 40.0749
314 3C0G 3AM 0.000003198 0.56781 40.1709
315 5DH3 5BS 0.000004319 0.57679 40.3175
316 5DA3 58V 0.00000004851 0.649 40.3774
317 2WU6 DKI 0.000000008579 0.71412 40.4199
318 3SRV S19 0.000000005312 0.70672 40.4332
319 3SLS ANP 0.0000001003 0.65896 40.4605
320 4CQE CQE 0.000002227 0.5934 40.6475
321 2V7O DRN 0.0000005357 0.58831 40.7738
322 4F4P 0SB 0.000004364 0.63022 41.0256
323 5MY8 RXZ 0.000004886 0.58392 41.2533
324 4JDI ANP 0.000001298 0.60208 41.3295
325 2JLD AG1 0.000001216 0.62849 41.3706
326 5IH9 6BF 0.000005549 0.59842 41.4925
327 4YLL 4E3 0.0000005534 0.62556 42.3823
328 3OFM 4B0 0.0000006621 0.59993 42.5714
329 2WQN ADP 0.00000535 0.53794 42.5806
330 1XJD STU 0.00000003956 0.57721 42.6087
331 4FG8 ATP 0.00001187 0.55551 43.1746
332 2F57 23D 0.0000171 0.50879 43.2177
333 4NM5 ADP 0.0003314 0.52271 43.2361
334 4XLI 1N1 0.000001612 0.53472 43.2836
335 2VN9 GVD 0.0000009635 0.57675 43.5216
336 3ZRM ZRM 0.000002089 0.58631 43.6658
337 5EFQ ADP 0.000000002916 0.72305 43.804
338 4IJP 1EH 0.00000000922 0.70616 43.8547
339 2X4Z X4Z 0.000119 0.52892 44.2568
340 1PHK ATP 0.000000006468 0.71013 44.2953
341 3KN5 ANP 0.00000148 0.58352 44.3077
342 4NST ADP 0.000000001461 0.73743 44.7293
343 3HMO STU 0.00000002889 0.67171 45.0292
344 4I6H 1C8 0.00004038 0.52471 45.1299
345 2YAK OSV 0.000009477 0.43062 45.2632
346 4C2V YJA 0.00003172 0.41394 45.2632
347 1Q8Y ADP 0.00000002356 0.68642 45.3083
348 1Q8Y ADE 0.0000006826 0.58299 45.3083
349 5G1X ADP 0.000001009 0.59826 45.614
350 5L8L ADP 0.00001317 0.53557 45.614
351 5N87 N66 0.0000001119 0.68508 45.6869
352 5LXM ADP 0.000000268 0.62566 45.9364
353 2VZ6 FEF 0.00000447 0.54475 46.0064
354 4C2W ANP 0.000002433 0.56975 46.2366
355 3F7Z 34O 0.000000486 0.61664 46.2857
356 5X8I SQZ 0.00000001114 0.69518 46.5318
357 3DAK ANP 0.000002716 0.57455 46.5517
358 5DEY 59T 0.00004038 0.57326 46.8013
359 5EYK 5U5 0.00001332 0.56653 47.1014
360 5EW9 5VC 0.0001851 0.56702 47.6015
361 4KS7 X4Z 0.0000198 0.45314 47.9452
362 3GC0 AMP 0.00001711 0.53361 48.0243
363 2XK9 XK9 0.003311 0.4856 48.1366
364 3PE2 E1B 0.000009688 0.599 48.368
365 5A6N U7E 0.0000133 0.55053 48.4099
366 3E5A VX6 0.000009869 0.45118 48.5075
367 2PVN P63 0.00000006218 0.68512 48.5795
368 5JZJ AN2 0.00000001361 0.68727 48.8215
369 4AUA 4AU 0.000001762 0.58673 48.8599
370 5HQ0 LZ9 0.0000000005625 0.765 49.6689
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