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Receptor
PDB id Resolution Class Description Source Keywords
5AP1 2.05 Å EC: 2.7.12.1 NATURALLY OCCURRING MUTATIONS IN THE MPS1 GENE PREDISPOSE CELLS TO KINASE INHIBITOR DRUG RESISTANCE. HOMO SAPIENS TRANSFERASE MPS1 PROTEIN KINASE MITOSIS DRUG RESISTANCE
Ref.: NATURALLY OCCURRING MUTATIONS IN THE MPS1 GENE PRED CELLS TO KINASE INHIBITOR DRUG RESISTANCE. CANCER RES. V. 75 3340 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MG A:1801;
A:1803;
A:1802;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
submit data
24.305 Mg [Mg+2...
GOL A:1800;
A:1799;
A:1797;
A:1798;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
O38 A:1796;
Valid;
none;
submit data
427.502 C24 H25 N7 O Cn1cc...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5N87 2.29 Å EC: 2.7.12.1 TTK KINASE DOMAIN IN COMPLEX WITH NTRC 0066-0 HOMO SAPIENS KINASE INHIBITOR MITOSIS MPS1 TRANSFERASE
Ref.: TARGET RESIDENCE TIME-GUIDED OPTIMIZATION ON TTK KI RESULTS IN INHIBITORS WITH POTENT ANTI-PROLIFERATIV ACTIVITY. J. MOL. BIOL. V. 429 2211 2017
Members (15)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 5N9S ic50 = 2.4 nM 8QW C29 H26 F N5 O4 S C[C@H](c1c....
2 5N87 ic50 = 0.9 nM N66 C33 H39 N7 O2 CCc1cccc(c....
3 5AP0 - AU5 C24 H32 N6 O3 CN1CCC(CC1....
4 5MRB Kd = 471 nM C5N C33 H40 N8 O2 CCc1cccc(c....
5 4C4J - X21 C26 H26 Cl N7 O2 CC(C)(C)OC....
6 5N93 Ki = 7.7 nM 8QE C17 H20 N6 O CC(C)(C)Nc....
7 4C4F - 7CE C17 H14 N4 O2 COc1ccccc1....
8 5AP6 - PWU C26 H27 N7 O2 Cc1ncc(n1C....
9 5EI6 ic50 = 0.099 uM 5OQ C21 H20 N4 O2 Cn1cc(cn1)....
10 5AP7 - SVE C35 H39 F3 N8 O3 CCc1cccc(c....
11 3WZK ic50 = 58 nM O23 C21 H19 N5 O S c1cc(sc1)C....
12 5EHY ic50 = 0.81 uM 5O4 C16 H11 N3 O c1ccc(cc1)....
13 5AP1 - O38 C24 H25 N7 O Cn1cc(cn1)....
14 5N84 ic50 = 6.7 nM 8Q5 C20 H23 N5 O CC(C)CNc1c....
15 5EI8 ic50 = 0.008 uM 5OE C22 H20 N8 O Cn1cc(cn1)....
70% Homology Family (20)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 3HMP ic50 = 38.41 uM CX4 C12 H12 Cl N3 c1cc2c(cc1....
2 3HMO ic50 = 0.102 uM STU C28 H26 N4 O3 C[C@@]12[C....
3 6H3K Ki = 0.11 mM FMW C24 H30 N8 O CCOc1cc(cc....
4 5EH0 Ki = 0.0005 uM 5NW C23 H27 N7 O CC(C)(C)CN....
5 4D2S ic50 = 0.02 uM DYK C24 H26 N6 O2 CN1CCC(CC1....
6 5N9S ic50 = 2.4 nM 8QW C29 H26 F N5 O4 S C[C@H](c1c....
7 5N87 ic50 = 0.9 nM N66 C33 H39 N7 O2 CCc1cccc(c....
8 5AP0 - AU5 C24 H32 N6 O3 CN1CCC(CC1....
9 5MRB Kd = 471 nM C5N C33 H40 N8 O2 CCc1cccc(c....
10 4C4J - X21 C26 H26 Cl N7 O2 CC(C)(C)OC....
11 5N93 Ki = 7.7 nM 8QE C17 H20 N6 O CC(C)(C)Nc....
12 4C4F - 7CE C17 H14 N4 O2 COc1ccccc1....
13 5AP6 - PWU C26 H27 N7 O2 Cc1ncc(n1C....
14 5EI6 ic50 = 0.099 uM 5OQ C21 H20 N4 O2 Cn1cc(cn1)....
15 5AP7 - SVE C35 H39 F3 N8 O3 CCc1cccc(c....
16 3WZK ic50 = 58 nM O23 C21 H19 N5 O S c1cc(sc1)C....
17 5EHY ic50 = 0.81 uM 5O4 C16 H11 N3 O c1ccc(cc1)....
18 5AP1 - O38 C24 H25 N7 O Cn1cc(cn1)....
19 5N84 ic50 = 6.7 nM 8Q5 C20 H23 N5 O CC(C)CNc1c....
20 5EI8 ic50 = 0.008 uM 5OE C22 H20 N8 O Cn1cc(cn1)....
50% Homology Family (20)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 3HMP ic50 = 38.41 uM CX4 C12 H12 Cl N3 c1cc2c(cc1....
2 3HMO ic50 = 0.102 uM STU C28 H26 N4 O3 C[C@@]12[C....
3 6H3K Ki = 0.11 mM FMW C24 H30 N8 O CCOc1cc(cc....
4 5EH0 Ki = 0.0005 uM 5NW C23 H27 N7 O CC(C)(C)CN....
5 4D2S ic50 = 0.02 uM DYK C24 H26 N6 O2 CN1CCC(CC1....
6 5N9S ic50 = 2.4 nM 8QW C29 H26 F N5 O4 S C[C@H](c1c....
7 5N87 ic50 = 0.9 nM N66 C33 H39 N7 O2 CCc1cccc(c....
8 5AP0 - AU5 C24 H32 N6 O3 CN1CCC(CC1....
9 5MRB Kd = 471 nM C5N C33 H40 N8 O2 CCc1cccc(c....
10 4C4J - X21 C26 H26 Cl N7 O2 CC(C)(C)OC....
11 5N93 Ki = 7.7 nM 8QE C17 H20 N6 O CC(C)(C)Nc....
12 4C4F - 7CE C17 H14 N4 O2 COc1ccccc1....
13 5AP6 - PWU C26 H27 N7 O2 Cc1ncc(n1C....
14 5EI6 ic50 = 0.099 uM 5OQ C21 H20 N4 O2 Cn1cc(cn1)....
15 5AP7 - SVE C35 H39 F3 N8 O3 CCc1cccc(c....
16 3WZK ic50 = 58 nM O23 C21 H19 N5 O S c1cc(sc1)C....
17 5EHY ic50 = 0.81 uM 5O4 C16 H11 N3 O c1ccc(cc1)....
18 5AP1 - O38 C24 H25 N7 O Cn1cc(cn1)....
19 5N84 ic50 = 6.7 nM 8Q5 C20 H23 N5 O CC(C)CNc1c....
20 5EI8 ic50 = 0.008 uM 5OE C22 H20 N8 O Cn1cc(cn1)....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: O38; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 O38 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5N87; Ligand: N66; Similar sites found with APoc: 772
This union binding pocket(no: 1) in the query (biounit: 5n87.bio1) has 39 residues
No: Leader PDB Ligand Sequence Similarity
1 5C8W PCG None
2 6F7X MFU None
3 1UO4 PIH None
4 1UO5 PIH None
5 1RDL MMA None
6 4WG0 CHD None
7 3ZO7 K6H None
8 1RV1 IMZ None
9 4ZSI 4R1 None
10 4RHP PEF 0.851064
11 4CSD MFU 1.10294
12 3QRC SCR 1.27389
13 4PU5 ANP 1.27796
14 2Z77 HE7 1.43885
15 5FUI APY 1.51515
16 2HRL SIA GAL SIA BGC NGA CEQ 1.5748
17 1Y52 BTN 1.5873
18 2PNC CLU 1.59744
19 2Z48 A2G 1.59744
20 2Z48 NGA 1.59744
21 3PGU OLA 1.59744
22 4GGZ BTN 1.73913
23 4UTW RFW 1.74672
24 3R9V DXC 1.74825
25 3VPD ANP 1.77936
26 4C5N ACP 1.81159
27 4ZH7 FUC GAL NAG GAL FUC 1.84162
28 2D6M LBT 1.88679
29 2QHV OC9 1.90476
30 6EZ6 C5Z 1.91693
31 5Y72 DST 1.91693
32 5J75 6GQ 1.91693
33 4UCI ADN 1.91693
34 3DER ALA LYS 1.91693
35 4CC6 L5Y 1.91693
36 5AYE BMA BMA 1.91693
37 1SZO CAX 1.94553
38 2ATJ BHO 1.94805
39 4GN8 ASO 2.00669
40 2GWH PCI 2.01342
41 5EJL C2E 2.01613
42 2TPI ILE VAL 2.18341
43 5SVV FMN 2.18978
44 5N26 CPT 2.1978
45 4YVN EBS 2.23642
46 6C1S EFV 2.23642
47 1VRP IOM 2.23642
48 1GQG DCD 2.23642
49 4G7A AZM 2.23642
50 5AE9 OKO 2.23642
51 1OLM VTQ 2.23642
52 4HPP GLU 2.23642
53 1VRP ADP 2.23642
54 1SR9 KIV 2.23642
55 4J0M BLD 2.23642
56 1I7L ATP 2.26537
57 4RDL FUC GAL NDG FUC 2.27273
58 3VKX T3 2.29885
59 4Q0A 4OA 2.31788
60 1SWG BTN 2.34375
61 5C1M OLC 2.36486
62 4P7X YCP 2.39726
63 4P7X AKG 2.39726
64 2AGC DAO 2.46914
65 3RGA LSB 2.4735
66 3VPC ADP 2.48227
67 1SU2 ATP 2.51572
68 2PTM CMP 2.52525
69 3X01 AMP 2.54453
70 5MRH Q9Z 2.55591
71 1F9V ADP 2.55591
72 5KJW 53C 2.55591
73 5VKM GAL SIA 2.55591
74 4OCV ANP 2.55591
75 4PZ6 GMP 2.55591
76 2Q8E OGA 2.55591
77 2P5B OGA 2.55591
78 4QDC ASD 2.55591
79 4QCK ASD 2.55591
80 4XJ6 GH3 2.55591
81 5KR7 6X9 2.55591
82 3U6W KIV 2.55591
83 4NOS ITU 2.55591
84 4WOE ADP 2.55591
85 1RYD GLC 2.58398
86 3HPY MCT 2.589
87 3NJQ NJQ 2.59067
88 1J3R 6PG 2.63158
89 4ZU4 4TG 2.7027
90 4OCT AKG 2.7027
91 5NBW 8SK 2.7027
92 2PFC PLM 2.73224
93 3BP1 GUN 2.75862
94 3ZJX BOG 2.76817
95 2PUL ACP 2.77078
96 2RDE C2E 2.78884
97 3K0T BGC 2.7972
98 5DYO FLU 2.83019
99 3I0O ADP 2.8754
100 5GLT BGC GAL NAG GAL 2.8754
101 4U98 ACP 2.8754
102 3AKK ADP 2.8754
103 3ETH ATP 2.8754
104 1U6R IOM 2.8754
105 1PK8 ATP 2.8754
106 4UWH JXM 2.8754
107 2Z5Y HRM 2.8754
108 3TY5 ADP 2.8754
109 2OG7 SIN 2.8754
110 2AWN ADP 2.8754
111 3VSV XYP 2.8754
112 1MLD CIT 2.8754
113 3TY5 ATP 2.8754
114 4MZU TYD 2.88462
115 1AUX AGS 2.89389
116 3O0W MAN MAN MAN GLC 2.9304
117 4NFE BEN 2.95359
118 5FYR INS 3.02013
119 5XEG AKG 3.0303
120 3WV6 GAL GLC 3.04054
121 3WV6 GAL BGC 3.04054
122 5KBE IPH 3.05677
123 4V03 ADP 3.11284
124 3SAO DBH 3.125
125 3SAO NKN 3.125
126 4L4J NAG NAG BMA MAN NAG 3.16742
127 3UDZ ADP 3.19489
128 1F5F DHT 3.19489
129 1KDK DHT 3.19489
130 5VLQ ANP 3.19489
131 4LH7 1X8 3.19489
132 1OFL NGK GCD 3.19489
133 6FL8 TIY 3.19489
134 6FL8 ADP 3.19489
135 3JQ3 ADP 3.19489
136 4FFG 0U8 3.19489
137 4FFG LBS 3.19489
138 5D85 FLC 3.19489
139 1OFZ FUC 3.20513
140 1OFZ FUL 3.20513
141 6C0B PAM 3.20513
142 2C1P FNZ 3.21101
143 1IA9 ANP 3.21429
144 4MPO AMP 3.26797
145 2XOM GAL GAL GAL 3.28947
146 2F9W PAU 3.32103
147 2BS5 BGC GAL FUC 3.33333
148 3BXO SAM 3.34728
149 1XAP TTB 3.37079
150 2GQS C2R 3.37553
151 2GQR ADP 3.37553
152 2GQS ADP 3.37553
153 2XOC ADP 3.44828
154 3UW5 MAA CHG PRO 0DQ 3.44828
155 2DUA OXL 3.44828
156 3ZW2 NAG GAL FUC 3.44828
157 2CFM AMP 3.51438
158 1OBD ATP 3.51438
159 4MOB ADP 3.51438
160 3SJK LYS PRO VAL LEU ARG THR ALA 3.51438
161 4C2G ALA ALA ALA ALA 3.51438
162 3KJS DQ1 3.51438
163 1UH4 GLC GLC GLC GLC GLC GLC 3.51438
164 3NEM ATP 3.51438
165 2P4S DIH 3.51438
166 3T1A 5MA 3.5524
167 5ZCT ANP 3.59477
168 4GLW 0XT 3.60656
169 4EE7 PIS 3.61842
170 4DK7 0KS 3.64372
171 1C1L GAL BGC 3.64964
172 5EPQ OLA 3.65854
173 5HV0 AKG 3.68664
174 4QAC KK3 3.68664
175 3EW2 BTN 3.7037
176 4IAW LIZ 3.7234
177 5TZO 7V7 3.7234
178 1P6O HPY 3.72671
179 5IXH OTP 3.72671
180 1GT4 UNA 3.77358
181 3SK2 GRI 3.78788
182 5T96 79J 3.80117
183 1XX4 BAM 3.83142
184 2Z3U CRR 3.83387
185 3JU6 ANP 3.83387
186 3WVR AMP 3.83387
187 3A76 SPD 3.83387
188 4UHL VFV 3.83387
189 1IZC PYR 3.83387
190 4BE9 7P9 3.83387
191 2VDY HCY 3.83387
192 6F5W KG1 3.83387
193 5HWV MBN 3.84615
194 5EO8 TFU 3.85852
195 6GVZ CHO 3.93443
196 4JLS 3ZE 3.94737
197 5L9V OGA 3.96825
198 4YJK URA 3.96825
199 5NFB 8VT 3.97727
200 1WAP TRP 4
201 3SHR CMP 4.01338
202 4K55 H6P 4.03226
203 6CB2 OLC 4.09556
204 3H7J PPY 4.11523
205 3VVY ET 4.12371
206 4LRJ ANP 4.14201
207 5YJS SAL 4.15335
208 2VPQ ANP 4.15335
209 2IO8 ADP 4.15335
210 5AWV GHP 3MY 3FG GHP GHP OMY 3FG NAG MAN 4.15335
211 5MW8 ATP 4.15335
212 1X8X TYR 4.15335
213 5L6G XYP 4.15335
214 5DCH 1YO 4.16667
215 3UYW TAU 4.20561
216 5OCG 9R5 4.2328
217 2D5X L35 4.25532
218 5K21 6QF 4.25532
219 1S9D AFB 4.26829
220 1RE0 AFB 4.26829
221 4FE2 AIR 4.31373
222 1DTL BEP 4.34783
223 4JNJ BTN 4.34783
224 4NPL AKG 4.4
225 1S68 AMP 4.41767
226 5H9P TD2 4.43038
227 1IS3 LAT 4.44444
228 5DG2 GAL GLC 4.44444
229 6A0S NDP 4.47284
230 3TII ANP 4.47284
231 4D52 GXL 4.47284
232 4D4U FUC GAL 4.47284
233 4D4U FUC GAL NAG 4.47284
234 5VNF VAL THR SER VAL VAL 4.47284
235 4D4U FUC GAL NDG FUC 4.47284
236 4OKD GLC GLC GLC 4.47284
237 5C3R HMU 4.47284
238 5C3R AKG 4.47284
239 4D52 GIV 4.47284
240 4Z28 BTN 4.47761
241 2AQX ATP 4.49827
242 4RYV ZEA 4.51613
243 2PYW ADP 4.52381
244 4O4Z N2O 4.54545
245 5V3Y 5V8 4.54545
246 3NZ1 3NY 4.5977
247 6FA4 D1W 4.62428
248 4V1F BQ1 4.65116
249 2V58 LZJ 4.67706
250 2VQD AP2 4.74138
251 5LHT TIH 4.7619
252 5EQY 5RA 4.79233
253 2HGS ADP 4.79233
254 3W5N RAM 4.79233
255 2XZ9 PYR 4.79233
256 3AI3 SOE 4.94297
257 3KO0 TFP 4.9505
258 4P25 FUC GAL NAG FUC 4.96689
259 1UMZ BGC BGC XYS BGC XYS GAL 5.03597
260 2E27 AB0 5.04202
261 5ODY 9SK 5.07246
262 1NYW DAU 5.07614
263 1SDW IYT 5.09554
264 5F6U 5VK 5.09554
265 3WUC GLC GAL 5.10949
266 6DW2 HD4 5.11182
267 2YRX AMP 5.11182
268 2NZ2 CIR 5.11182
269 2YKL NLD 5.11182
270 2R0D 4IP 5.11182
271 2R09 4IP 5.11182
272 6E08 NAP 5.11182
273 2FCU AKG 5.11182
274 3T3Z 9PL 5.11182
275 3AI0 PNW 5.11182
276 3THR C2F 5.11945
277 2GBB CIT 5.12821
278 5H9Q TD2 5.16129
279 4R78 AMP 5.17799
280 3I51 45C 5.18518
281 1A78 TDG 5.22388
282 6HDT BTN 5.26316
283 3OF1 CMP 5.28455
284 2YMZ LAT 5.38462
285 2ZL7 FUC GAL NGA 5.42373
286 3Q60 ATP 5.43131
287 1F52 ADP 5.43131
288 4LKK SIA GAL 5.43131
289 4QDF 30Q 5.43131
290 5U97 PIT 5.43131
291 5XJD 87L 5.45455
292 1LFO OLA 5.46875
293 4ZS4 ATP 5.53746
294 2W3L DRO 5.55556
295 4LCN GNG 5.58376
296 5AIG VPR 5.6
297 3VV1 GAL FUC 5.625
298 3KYF 5GP 5GP 5.62771
299 4O4F ATP 5.64516
300 4O4F IHP 5.64516
301 4N9I PCG 5.71429
302 5COU ATP 5.7508
303 3VOT ADP 5.7508
304 3ORQ ADP 5.7508
305 1ELI PYC 5.7508
306 3IO3 ADP 5.7508
307 1I82 BGC BGC 5.82011
308 5C1P ADP 5.88235
309 1T27 PCW 5.90406
310 3ZXE PGZ 6.01504
311 5XLY C2E 6.01504
312 5KWY C3S 6.01504
313 2R5V HHH 6.07029
314 3WXL ADP 6.07029
315 5MST FUM 6.07029
316 1CKN GTP 6.07029
317 2YW2 ATP 6.07029
318 3KC1 2T6 6.07029
319 3V4S ATP 6.07029
320 1LRH NLA 6.13497
321 3PDT ADP 6.18182
322 5FPX GLY SER SER HIS HIS HIS HIS HIS 6.19469
323 5Y4R C2E 6.2069
324 4RT1 C2E 6.25
325 3T4L ZEA 6.2963
326 4RF7 ARG 6.38978
327 5YK1 ANP 6.38978
328 4CYI ATP 6.38978
329 5OSW DIU 6.38978
330 1TW4 CHD 6.4
331 2ET1 GLV 6.46766
332 4Y24 TD2 6.49351
333 3NV3 GAL NAG MAN 6.52174
334 1MID LAP 6.59341
335 3NB0 G6P 6.70927
336 4YRI 4JH 6.70927
337 3GL0 HXX 6.70927
338 3GFZ FMN 6.70927
339 3DNT ATP 6.70927
340 3TPV ADE 6.70927
341 3I7V ATP 6.71642
342 4TV1 36M 6.77291
343 4N7C AEF 6.81818
344 5UC4 83S 6.81818
345 3AJH BL3 6.85484
346 2QL9 CIT 6.93642
347 5DMZ ADP 7.02875
348 4XMF HSM 7.02875
349 2IF8 ADP 7.02875
350 4BJX 73B 7.02875
351 5WUU 7UU 7.02875
352 4OFG PCG 7.02875
353 5U98 1KX 7.07071
354 1PVC ILE SER GLU VAL 7.14286
355 5BV6 35G 7.23684
356 1M0W ANP 7.34824
357 5M4Q PRO 7.34824
358 5FXD H7Y 7.34824
359 2H5Z CTO 7.37705
360 6GNO XDI 7.40741
361 5JAX 6J7 7.40741
362 4OAV ACP 7.4392
363 5Z46 8XL 7.44337
364 3OYW TDG 7.46269
365 1W6P NDG GAL 7.46269
366 3TDV GDP 7.51634
367 4FLP JQ1 7.56302
368 3CBC DBS 7.57576
369 5OES ADP 7.66773
370 4AZW ATP 7.66773
371 1LSH PLD 7.66773
372 5VZ0 ADP 7.66773
373 2OS2 OGA 7.66773
374 5W75 SUC 7.66773
375 5G48 1FL 7.66773
376 2I4O ATP 7.66773
377 5TKL G3H 7.66773
378 5XHA FRU FRU 7.66773
379 4WVO 3UZ 7.73481
380 2C1Q BTN 7.93651
381 3ZGJ RMN 7.98722
382 1EHI ADP 7.98722
383 5I0U DCY 8
384 5TFZ 7BC 8
385 1N5S ADL 8.03571
386 4KAX 4IP 8.07453
387 4G86 BNT 8.09859
388 3K5I ADP 8.18859
389 6CGD AKN 8.19672
390 6CGD GNP 8.19672
391 5I35 ANP 8.30671
392 1T36 ADP 8.30671
393 4ZU5 THM 8.33333
394 2DTJ THR 8.42697
395 3AB4 THR 8.42697
396 1Y7P RIP 8.52018
397 2G30 ALA ALA PHE 8.52713
398 4UCC ZKW 8.58369
399 5A0U CHT 8.6262
400 3OCP CMP 8.63309
401 1ULE GLA GAL NAG 8.66667
402 3HAV ATP 8.69565
403 3RV5 DXC 8.98876
404 4XYM A12 9.13043
405 4XZ3 ACP 9.13043
406 1GSA ADP 9.17722
407 6FOF LAT 9.18367
408 5LX9 OLB 9.26518
409 5FPE 3TR 9.26518
410 1VBH PEP 9.26518
411 1OW4 2AN 9.30233
412 2W5P CL8 9.39597
413 1ONI BEZ 9.42029
414 5K2M ADP 9.43396
415 5B09 4MX 9.61539
416 1ZTH ADP 9.68992
417 1ZP9 ATP 9.68992
418 2QK4 ATP 9.90415
419 1CBK ROI 10
420 3RE4 TO1 10.0775
421 2XG5 EC2 10.0917
422 2XG5 EC5 10.0917
423 5XQW 8EU 10.1382
424 3KMW ATP 10.3321
425 3PNA CMP 10.3896
426 3KP6 SAL 10.596
427 2BKK ADP 10.6061
428 5N0L ILE 10.6918
429 3VPB ADP 10.7143
430 2AKO ADP 10.757
431 1XK5 TPG 10.7843
432 5IM3 DTP 10.8626
433 4YZ5 SLT 10.8626
434 2PNZ 5GP 10.8626
435 2ALG DAO 10.8696
436 1NE6 SP1 10.9541
437 4ETZ C2E 11.1111
438 1OGX EQU 11.4504
439 1TZD ADP 11.5016
440 5INJ 6C7 11.5016
441 1W2D ADP 11.6981
442 4QXB OGA 11.7647
443 2YG2 FLC 12.2093
444 3WG3 A2G GAL NAG FUC 12.3596
445 4OUC 5ID 12.4601
446 6G34 5ID 12.4601
447 5BWD FUM 12.4601
448 4D00 SIA GAL NAG 12.5683
449 4BJ8 BTN 12.6984
450 5ML3 DL3 12.7517
451 3VY6 BGC BGC 12.766
452 5DXT 5H5 12.7796
453 5FI4 5XV 12.7796
454 3M3E GAL A2G NPO 13.0435
455 6E2B PT7 13.1579
456 6GWR FEW 13.4185
457 1I7M PUT 13.4328
458 6E8I PTR 13.6095
459 1WW5 SGA BGC 13.75
460 3C1X CKK 14.0575
461 1VR0 3SL 14.0575
462 3PAK MAN 14.1892
463 2CDO GAL AAL GAL AAL GAL AAL 14.375
464 2IDO TMP 14.5161
465 1U29 I3P 14.7287
466 5GZ9 ANP 14.7541
467 1VJY 460 15.016
468 4CRL C1I 15.3355
469 2QX0 PH2 15.3355
470 4RFR RHN 15.3355
471 5QIN J2V 15.655
472 4INW 1EY 15.7143
473 1JGS SAL 15.942
474 5CHR 4NC 16.0584
475 4XH0 ADP 16.2939
476 4I94 ANP 16.2939
477 4NS0 PIO 16.5414
478 1C3X 8IG 16.5414
479 4WVW SLT 16.6667
480 4RJD TFP 16.6667
481 4Y0X ADP 16.9329
482 2PZI AXX 16.9329
483 3KIF GDL 16.9811
484 4DFU QUE 17.0807
485 6AC9 ANP 17.2524
486 2Y6O 1N1 17.5258
487 6ES0 BW8 17.5719
488 1XZ3 ICF 17.8161
489 4JR7 GNP 17.8914
490 5C4L 4XR 18.8498
491 4UYG 73B 19.1083
492 3CF6 SP1 19.1617
493 4O1P ANP 19.8083
494 5EOB 5QQ 20.1278
495 1TQP ATP 20.4473
496 4IX4 ADP 20.4473
497 4GYI ADP 20.7668
498 1KTG AMP 21.0145
499 5OKT 9XK 21.0863
500 5W4W 9WG 21.0863
501 3PP0 03Q 21.0863
502 4KBA 1QM 21.0863
503 3VHE 42Q 21.0863
504 4ASE AV9 21.0863
505 4AG8 AXI 21.0863
506 1U59 STU 21.2544
507 4FF8 14S 21.4058
508 5UR1 YY9 21.865
509 3GQI ACP 22.0447
510 5MY8 RXZ 22.0447
511 1JPA ANP 22.1154
512 3PLS ANP 22.1477
513 4WW7 AMP 22.4599
514 6GIN IR2 22.6837
515 3H9R TAK 22.6837
516 4OTH DRN 23.0032
517 5LXT ACP 23.0769
518 4WOV 3SM 23.3227
519 5C03 AGS 23.3227
520 5T8O 76Z 23.4957
521 4F9C 0SX 23.9617
522 5TO8 7FM 24.1135
523 4GJ3 0XP 24.1722
524 1Y57 MPZ 24.6006
525 4E1Z 0MX 25.0859
526 6C7Y ADP 25.1748
527 5JGA 6KC 25.2396
528 4CSV STI 25.8182
529 2XVD AS6 25.8278
530 5M06 ADP 26.4493
531 1OPK P16 26.5176
532 5KJZ PCG 26.6667
533 5OMY 9YE 26.8371
534 2HZQ STR 27.0115
535 6E2O S0L 27.1186
536 4IDT T28 27.1565
537 4WB6 ATP 27.1565
538 1ZY5 ANP 27.3927
539 3IDB ANP 27.476
540 2QCS ANP 27.476
541 3FHI ANP 27.476
542 4WB7 ATP 27.476
543 1RE8 BD2 27.476
544 5FBN 5WF 27.6753
545 2GU8 796 27.7955
546 5USZ SKE 28.0277
547 5EKO N17 29.393
548 4TWP AXI 29.5203
549 1OUK 084 29.7125
550 4LOO SB4 29.7125
551 2R5T ANP 30.0319
552 1BYG STU 30.2158
553 5ZTN CUR 30.3514
554 4G17 0VN 30.3514
555 2QLU ADE 30.5732
556 2CSN CKI 30.6397
557 6BFN DL1 30.6709
558 5UIU 8CG 31.9489
559 4IJP 1EH 32.2684
560 4Y85 499 32.2684
561 4UX9 ANP 32.5879
562 4IZY 1J2 32.5879
563 2HY0 306 32.5879
564 3TKI S25 32.5879
565 3GNI ATP 32.9073
566 4FL3 ANP 32.9073
567 3TTI KBI 32.9073
568 4WHZ 3NL 32.9073
569 3PTG 932 32.9073
570 6F3G CJN 33.2203
571 4NST ADP 33.5463
572 4YZC STU 33.5463
573 3E8N ATP 33.5463
574 3E8N VRA 33.5463
575 3ORK AGS 33.5463
576 4M69 ANP 33.5689
577 5LVP ATP 34.0836
578 3RWP ABQ 34.0836
579 5EFQ ADP 34.1853
580 4CLI 5P8 34.1853
581 4EWH T77 34.5455
582 2X2M X2M 34.7134
583 4NFN 2KC 34.8243
584 4Q5H ANP 35.0575
585 3GC8 B45 35.1351
586 6GZD LCI 35.4633
587 4EUU BX7 35.4633
588 5HCY 60D 35.4633
589 5WO4 B7V 36.0927
590 3RI1 3RH 36.1022
591 2H8H H8H 36.1022
592 5VC5 96M 36.1022
593 4E93 GUI 36.1022
594 5CKW ANP 36.1022
595 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 36.1022
596 2JDR L20 36.1022
597 4H3Q ANP 36.1878
598 5KO1 6UY 36.3958
599 4ONA UW1 36.4217
600 4H3P ANP 36.4641
601 1BHX ASP PHE GLU GLU ILE 36.6667
602 5LPZ ADP 36.7412
603 3PE2 E1B 36.7953
604 2PVN P63 36.9318
605 2Z7R STU 37.0607
606 5YF9 NIO 37.4631
607 5CEO 50D 37.6667
608 5HVJ ANP 37.6997
609 2OO8 RAJ 37.8549
610 3MVH WFE 38.0192
611 5LPB ADP 38.1757
612 5JKG 6LF 38.2637
613 3LXK MI1 38.3387
614 4Y93 746 38.3387
615 4G31 0WH 38.4615
616 5NKB 8ZT 38.5621
617 5WNL STU 38.6581
618 3PVW QRX 38.6581
619 5UKL SIX 38.6581
620 3UIM ANP 38.6581
621 3GC0 AMP 38.6581
622 3LXN MI1 38.9776
623 2B9J ADP 39.2971
624 2B9H ADP 39.2971
625 2B9I ADP 39.2971
626 2B9F ADP 39.2971
627 3VRY B43 39.2971
628 5UPK ANP 39.2971
629 4U0I 0LI 39.3651
630 3NW7 LGV 39.4137
631 3G5D 1N1 39.5105
632 6GQM F8H 39.6166
633 3EKK GS2 39.7394
634 5HES 032 39.7394
635 3BU5 ATP 39.8693
636 3V8S 0HD 39.9361
637 4PNI KQQ 39.9361
638 4L9I 8PR 39.9361
639 4BTK DTQ 39.9361
640 1IR3 ANP 40.1961
641 4OH4 ANP 40.2556
642 5DBX ANP 40.2556
643 3CY2 MB9 40.2556
644 4N70 2HX 40.2556
645 4YZN 4K5 40.4181
646 3M2W L8I 40.4682
647 4FG8 ATP 40.5751
648 4P5Z Q7M 40.5751
649 1XJD STU 40.5751
650 4X7Q 3YR 40.7051
651 1EB1 ASP TYR GLU PRO ILE PRO GLU GLU ALA PHE 40.7407
652 4AT3 LTI 40.8027
653 6C0T EE4 40.8946
654 3BZ3 YAM 40.942
655 4XV1 904 41.0959
656 2BPM 529 41.1003
657 3TXO 07U 41.2141
658 4UXL 5P8 41.2141
659 3KRL KRL 41.2141
660 5XVG 8FX 41.2969
661 4YMJ 4EJ 41.4474
662 4NW6 2NS 41.4861
663 1Q8Y ADE 41.5335
664 1Q8Y ADP 41.5335
665 1CM8 ANP 41.5335
666 3ALN ANP 41.5335
667 4WNK 453 41.5335
668 3FC2 IBI 41.5335
669 5TA6 79D 41.5335
670 5JFS 6K0 41.5335
671 5U6C 7YS 41.5873
672 2ZV2 609 41.6107
673 3KN5 ANP 41.853
674 1O9U ADZ 41.853
675 4NM5 ADP 41.853
676 3F7Z 34O 41.853
677 3HZT J60 41.853
678 3ZRM ZRM 41.853
679 2XK9 XK9 41.853
680 4CFU 2WC 41.9142
681 3AQV TAK 42.029
682 6GUE FB8 42.053
683 6CQF F97 42.0875
684 2WQN ADP 42.1725
685 3FHR P4O 42.1725
686 4BCM T7Z 42.1927
687 4BCQ TJF 42.1927
688 4I6H 1C8 42.2078
689 4BCN T9N 42.3333
690 3SLS ANP 42.4342
691 3SLS 77D 42.4342
692 4KS7 X4Z 42.4658
693 4Y8D 49J 42.492
694 2PVF ACP 42.492
695 2RIO ADP 42.492
696 2JLD AG1 42.492
697 5BVE 4VG 42.492
698 5Y80 IRE 42.492
699 2XMY CDK 42.6175
700 5MJA 7O3 42.623
701 5LMK 6ZK 42.7609
702 4U44 3D9 42.8115
703 3IGO ANP 42.8115
704 2WEL K88 42.8115
705 1K3A ACP 42.8571
706 3SXS PP2 42.9104
707 2A19 ANP 42.9577
708 5VCV 1N1 43.0868
709 4L3L 5FI 43.0921
710 5G1X ADP 43.1579
711 5L8L ADP 43.1579
712 4ITH RCM 43.1973
713 2OFV 242 43.3213
714 5DEY 59T 43.4343
715 4K33 ACP 43.4505
716 5LXM ADP 43.4629
717 4CQE CQE 43.5252
718 5DRB 5FJ 43.6426
719 1U5R ATP 43.77
720 4UAL 3FV 43.77
721 5LI9 ACP 43.77
722 5ODT ADP 43.8163
723 6CZ3 FLJ 43.9394
724 4AUA 4AU 43.9739
725 4RFM 3P6 43.985
726 5HQ0 LZ9 44.0397
727 6GU6 1QK 44.0397
728 2YAB AMP 44.0895
729 6BXI ANP 44.0895
730 5DH3 5BS 44.0895
731 5H2U 1N1 44.1948
732 2J7T 274 44.3709
733 5JZJ AN2 44.4444
734 2VN9 GVD 44.5183
735 4QTB 38Z 44.7284
736 2F57 23D 44.7284
737 4QMN DB8 44.8387
738 4C2V YJA 44.9123
739 3C0G 3AM 45.0479
740 3DLS ADP 45.0479
741 5LI1 ANP 45.0479
742 5IH9 6BF 45.0479
743 3SRV S19 45.1264
744 5AX9 4KT 45.1299
745 3GGF GVD 45.1827
746 4AU8 Z3R 45.2703
747 4WNP 3RJ 45.2962
748 1PHK ATP 45.302
749 3E7O 35F 45.3674
750 5EW9 5VC 45.3875
751 4USF 6UI 45.3947
752 3DAK ANP 45.5172
753 2HK5 1BM 45.5556
754 2F2U M77 45.6869
755 4BFM ANP 45.6869
756 5AWM ANP 45.6869
757 4F4P 0SB 45.7875
758 1V0O INR 45.8333
759 4C2W ANP 45.8781
760 1UNH IXM 45.8904
761 3O0G 3O0 45.8904
762 3E5A VX6 45.8955
763 4BHN BH9 46.0064
764 2WEI VGG 46.3415
765 5EYK 5U5 46.7391
766 2YAK OSV 47.0175
767 4DC2 ADE 47.2843
768 5A6N U7E 47.7032
769 2VZ6 FEF 47.9233
770 4A4X JUP 48.0287
771 2V7O DRN 48.8818
772 6CMJ F6J 49.8403
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