Receptor
PDB id Resolution Class Description Source Keywords
5AP1 2.05 Å EC: 2.7.12.1 NATURALLY OCCURRING MUTATIONS IN THE MPS1 GENE PREDISPOSE CELLS TO KINASE INHIBITOR DRUG RESISTANCE. HOMO SAPIENS TRANSFERASE MPS1 PROTEIN KINASE MITOSIS DRUG RESISTANCE
Ref.: NATURALLY OCCURRING MUTATIONS IN THE MPS1 GENE PRED CELLS TO KINASE INHIBITOR DRUG RESISTANCE. CANCER RES. V. 75 3340 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MG A:1801;
A:1803;
A:1802;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
submit data
24.305 Mg [Mg+2...
GOL A:1800;
A:1799;
A:1797;
A:1798;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
O38 A:1796;
Valid;
none;
submit data
427.502 C24 H25 N7 O Cn1cc...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5N87 2.29 Å EC: 2.7.12.1 TTK KINASE DOMAIN IN COMPLEX WITH NTRC 0066-0 HOMO SAPIENS KINASE INHIBITOR MITOSIS MPS1 TRANSFERASE
Ref.: TARGET RESIDENCE TIME-GUIDED OPTIMIZATION ON TTK KI RESULTS IN INHIBITORS WITH POTENT ANTI-PROLIFERATIV ACTIVITY. J. MOL. BIOL. V. 429 2211 2017
Members (15)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 5N9S ic50 = 2.4 nM 8QW C29 H26 F N5 O4 S C[C@H](c1c....
2 5N87 ic50 = 0.9 nM N66 C33 H39 N7 O2 CCc1cccc(c....
3 5AP0 - AU5 C24 H32 N6 O3 CN1CCC(CC1....
4 5MRB Kd = 471 nM C5N C33 H40 N8 O2 CCc1cccc(c....
5 4C4J - X21 C26 H26 Cl N7 O2 CC(C)(C)OC....
6 5N93 Ki = 7.7 nM 8QE C17 H20 N6 O CC(C)(C)Nc....
7 4C4F - 7CE C17 H14 N4 O2 COc1ccccc1....
8 5AP6 - PWU C26 H27 N7 O2 Cc1ncc(n1C....
9 5EI6 ic50 = 0.099 uM 5OQ C21 H20 N4 O2 Cn1cc(cn1)....
10 5AP7 - SVE C35 H39 F3 N8 O3 CCc1cccc(c....
11 3WZK ic50 = 58 nM O23 C21 H19 N5 O S c1cc(sc1)C....
12 5EHY ic50 = 0.81 uM 5O4 C16 H11 N3 O c1ccc(cc1)....
13 5AP1 - O38 C24 H25 N7 O Cn1cc(cn1)....
14 5N84 ic50 = 6.7 nM 8Q5 C20 H23 N5 O CC(C)CNc1c....
15 5EI8 ic50 = 0.008 uM 5OE C22 H20 N8 O Cn1cc(cn1)....
70% Homology Family (19)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 3HMP ic50 = 38.41 uM CX4 C12 H12 Cl N3 c1cc2c(cc1....
2 3HMO ic50 = 0.102 uM STU C28 H26 N4 O3 C[C@@]12[C....
3 5N9S ic50 = 2.4 nM 8QW C29 H26 F N5 O4 S C[C@H](c1c....
4 5N87 ic50 = 0.9 nM N66 C33 H39 N7 O2 CCc1cccc(c....
5 5AP0 - AU5 C24 H32 N6 O3 CN1CCC(CC1....
6 5MRB Kd = 471 nM C5N C33 H40 N8 O2 CCc1cccc(c....
7 4C4J - X21 C26 H26 Cl N7 O2 CC(C)(C)OC....
8 5N93 Ki = 7.7 nM 8QE C17 H20 N6 O CC(C)(C)Nc....
9 4C4F - 7CE C17 H14 N4 O2 COc1ccccc1....
10 5AP6 - PWU C26 H27 N7 O2 Cc1ncc(n1C....
11 5EI6 ic50 = 0.099 uM 5OQ C21 H20 N4 O2 Cn1cc(cn1)....
12 5AP7 - SVE C35 H39 F3 N8 O3 CCc1cccc(c....
13 3WZK ic50 = 58 nM O23 C21 H19 N5 O S c1cc(sc1)C....
14 5EHY ic50 = 0.81 uM 5O4 C16 H11 N3 O c1ccc(cc1)....
15 5AP1 - O38 C24 H25 N7 O Cn1cc(cn1)....
16 5N84 ic50 = 6.7 nM 8Q5 C20 H23 N5 O CC(C)CNc1c....
17 5EI8 ic50 = 0.008 uM 5OE C22 H20 N8 O Cn1cc(cn1)....
18 5EH0 Ki = 0.0005 uM 5NW C23 H27 N7 O CC(C)(C)CN....
19 4D2S ic50 = 0.02 uM DYK C24 H26 N6 O2 CN1CCC(CC1....
50% Homology Family (19)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 3HMP ic50 = 38.41 uM CX4 C12 H12 Cl N3 c1cc2c(cc1....
2 3HMO ic50 = 0.102 uM STU C28 H26 N4 O3 C[C@@]12[C....
3 5N9S ic50 = 2.4 nM 8QW C29 H26 F N5 O4 S C[C@H](c1c....
4 5N87 ic50 = 0.9 nM N66 C33 H39 N7 O2 CCc1cccc(c....
5 5AP0 - AU5 C24 H32 N6 O3 CN1CCC(CC1....
6 5MRB Kd = 471 nM C5N C33 H40 N8 O2 CCc1cccc(c....
7 4C4J - X21 C26 H26 Cl N7 O2 CC(C)(C)OC....
8 5N93 Ki = 7.7 nM 8QE C17 H20 N6 O CC(C)(C)Nc....
9 4C4F - 7CE C17 H14 N4 O2 COc1ccccc1....
10 5AP6 - PWU C26 H27 N7 O2 Cc1ncc(n1C....
11 5EI6 ic50 = 0.099 uM 5OQ C21 H20 N4 O2 Cn1cc(cn1)....
12 5AP7 - SVE C35 H39 F3 N8 O3 CCc1cccc(c....
13 3WZK ic50 = 58 nM O23 C21 H19 N5 O S c1cc(sc1)C....
14 5EHY ic50 = 0.81 uM 5O4 C16 H11 N3 O c1ccc(cc1)....
15 5AP1 - O38 C24 H25 N7 O Cn1cc(cn1)....
16 5N84 ic50 = 6.7 nM 8Q5 C20 H23 N5 O CC(C)CNc1c....
17 5EI8 ic50 = 0.008 uM 5OE C22 H20 N8 O Cn1cc(cn1)....
18 5EH0 Ki = 0.0005 uM 5NW C23 H27 N7 O CC(C)(C)CN....
19 4D2S ic50 = 0.02 uM DYK C24 H26 N6 O2 CN1CCC(CC1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: O38; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 O38 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5N87; Ligand: N66; Similar sites found: 466
This union binding pocket(no: 1) in the query (biounit: 5n87.bio1) has 39 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1RDL MMA 0.01981 0.42467 None
2 4WG0 CHD 0.02136 0.42403 None
3 4PU5 ANP 0.004775 0.41841 1.27796
4 5FUI APY 0.00276 0.47214 1.51515
5 2HRL SIA GAL SIA BGC NGA CEQ 0.004912 0.45249 1.5748
6 2PNC CLU 0.007345 0.45295 1.59744
7 3PGU OLA 0.02096 0.41535 1.59744
8 4GGZ BTN 0.001257 0.47286 1.73913
9 3R9V DXC 0.01634 0.43216 1.74825
10 4C5N ACP 0.00479 0.41244 1.81159
11 2D6M LBT 0.001068 0.50637 1.88679
12 2QHV OC9 0.03765 0.40579 1.90476
13 4CC6 L5Y 0.03899 0.40498 1.91693
14 2TPI ILE VAL 0.02007 0.40254 2.18341
15 5SVV FMN 0.008876 0.41269 2.18978
16 4AZT LY2 0.000482 0.49932 2.23642
17 4YVN EBS 0.003447 0.46743 2.23642
18 4ANW O92 0.00007615 0.46497 2.23642
19 1VRP IOM 0.006946 0.43844 2.23642
20 5NCY 8TK 0.001148 0.42608 2.23642
21 1OLM VTQ 0.004063 0.40985 2.23642
22 1SR9 KIV 0.04545 0.40682 2.23642
23 4RDL FUC GAL NDG FUC 0.01589 0.43109 2.27273
24 4P7X AKG 0.006835 0.42457 2.39726
25 4P7X YCP 0.006835 0.42457 2.39726
26 3VPC ADP 0.002094 0.43737 2.48227
27 3X01 AMP 0.001641 0.48566 2.54453
28 5MRH Q9Z 0.0004358 0.50762 2.55591
29 4OCV ANP 0.001616 0.44988 2.55591
30 2Q8E OGA 0.01023 0.44196 2.55591
31 4WOE ADP 0.01449 0.43487 2.55591
32 5KR7 6X9 0.02503 0.41136 2.55591
33 4NOS ITU 0.04258 0.40294 2.55591
34 1J3R 6PG 0.009417 0.43323 2.63158
35 4ZU4 4TG 0.01084 0.41858 2.7027
36 4OCT AKG 0.02452 0.41182 2.7027
37 5NBW 8SK 0.02789 0.40535 2.7027
38 3ZJX BOG 0.02302 0.42276 2.76817
39 3I0O ADP 0.0002765 0.51166 2.8754
40 4U98 ACP 0.0008664 0.47113 2.8754
41 3AKK ADP 0.0009257 0.46098 2.8754
42 1PK8 ATP 0.001473 0.43384 2.8754
43 4UWH JXM 0.008419 0.4276 2.8754
44 2Z5Y HRM 0.01774 0.42314 2.8754
45 3O0W MAN MAN MAN GLC 0.01073 0.43033 2.9304
46 3WV6 GAL GLC 0.002119 0.47673 3.04054
47 3WV6 GAL BGC 0.003036 0.46952 3.04054
48 1EPB REA 0.009931 0.42042 3.04878
49 5KBE IPH 0.03071 0.41452 3.05677
50 4LH7 1X8 0.01397 0.43223 3.19489
51 1OFL NGK GCD 0.02159 0.42044 3.19489
52 3JQ3 ADP 0.02711 0.40956 3.19489
53 4FFG 0U8 0.03538 0.40929 3.19489
54 4FFG LBS 0.02281 0.40767 3.19489
55 3UDZ ADP 0.00005111 0.40541 3.19489
56 2C1P FNZ 0.03866 0.40155 3.21101
57 1IA9 ANP 0.0001316 0.49984 3.21429
58 4MPO AMP 0.03244 0.40694 3.26797
59 2F9W PAU 0.02377 0.41641 3.32103
60 2GQS C2R 0.0003231 0.49683 3.37553
61 2GQS ADP 0.01401 0.41324 3.37553
62 3UW5 MAA CHG PRO 0DQ 0.04247 0.40847 3.44828
63 2CFM AMP 0.000547 0.49651 3.51438
64 3SJK LYS PRO VAL LEU ARG THR ALA 0.01947 0.42663 3.51438
65 1UH4 GLC GLC GLC GLC GLC GLC 0.04251 0.40884 3.51438
66 3NEM ATP 0.03152 0.40616 3.51438
67 3T1A 5MA 0.01569 0.40448 3.5524
68 4EE7 PIS 0.03195 0.40581 3.61842
69 4DK7 0KS 0.01895 0.40068 3.64372
70 3EW2 BTN 0.001748 0.4707 3.7037
71 4IAW LIZ 0.002341 0.46422 3.7234
72 5IXH OTP 0.002801 0.40661 3.72671
73 1GT4 UNA 0.01783 0.40819 3.77358
74 3SK2 GRI 0.03463 0.41279 3.78788
75 3JU6 ANP 0.01158 0.43749 3.83387
76 3WVR AMP 0.005535 0.43652 3.83387
77 1JL0 PUT 0.01858 0.408 3.83387
78 5L9V OGA 0.01541 0.42224 3.96825
79 1WAP TRP 0.02336 0.40252 4
80 3SHR CMP 0.001929 0.46851 4.01338
81 4K55 H6P 0.00891 0.44224 4.03226
82 3H7J PPY 0.01094 0.42202 4.11523
83 4LRJ ANP 0.000002173 0.42981 4.14201
84 2IO8 ADP 0.001612 0.43546 4.15335
85 5AWV GHP 3MY 3FG GHP GHP OMY 3FG NAG MAN 0.02295 0.42624 4.15335
86 5MW8 ATP 0.0000544 0.4207 4.15335
87 5DCH 1YO 0.005776 0.4569 4.16667
88 3UYW TAU 0.04747 0.41124 4.20561
89 1S9D AFB 0.02687 0.40977 4.26829
90 4FE2 AIR 0.0006086 0.49414 4.31373
91 4JNJ BTN 0.002004 0.4581 4.34783
92 5DG2 GAL GLC 0.00514 0.43346 4.44444
93 3TII ANP 0.002564 0.46219 4.47284
94 4D4U FUC GAL 0.01478 0.42838 4.47284
95 4D4U FUC GAL NDG FUC 0.02573 0.41073 4.47284
96 4OKD GLC GLC GLC 0.03893 0.40629 4.47284
97 5C3R HMU 0.0206 0.402 4.47284
98 5C3R AKG 0.0206 0.402 4.47284
99 2AQX ATP 0.01254 0.40299 4.49827
100 4RYV ZEA 0.00105 0.48203 4.51613
101 2PYW ADP 0.00007252 0.40831 4.52381
102 3NZ1 3NY 0.009185 0.43667 4.5977
103 2V58 LZJ 0.002463 0.40969 4.67706
104 2VQD AP2 0.001031 0.45481 4.74138
105 5E89 TD2 0.006573 0.42902 5.03597
106 1SDW IYT 0.02245 0.41012 5.09554
107 5F6U 5VK 0.04047 0.40034 5.09554
108 2YRX AMP 0.006211 0.45431 5.11182
109 2R0D 4IP 0.02772 0.41694 5.11182
110 3AI0 PNW 0.02838 0.4016 5.11182
111 2GBB CIT 0.04739 0.4042 5.12821
112 5H9Q TD2 0.007842 0.4223 5.16129
113 4R78 AMP 0.003042 0.4634 5.17799
114 3OF1 CMP 0.01005 0.43178 5.28455
115 2YMZ LAT 0.005417 0.4313 5.38462
116 3Q60 ATP 0.000007446 0.56987 5.43131
117 1F52 ADP 0.004882 0.4434 5.43131
118 1LFO OLA 0.01159 0.41055 5.46875
119 4ZS4 ATP 0.0002247 0.48918 5.53746
120 2W3L DRO 0.03765 0.41083 5.55556
121 5AIG VPR 0.006491 0.44153 5.6
122 3VV1 GAL FUC 0.005158 0.46163 5.625
123 4O4F ATP 0.004219 0.41474 5.64516
124 4O4F IHP 0.004953 0.40905 5.64516
125 3VOT ADP 0.009092 0.43402 5.7508
126 3ORQ ADP 0.004929 0.42422 5.7508
127 5XLY C2E 0.006093 0.42691 6.01504
128 2R5V HHH 0.001447 0.46981 6.07029
129 5MST FUM 0.02488 0.41536 6.07029
130 2YW2 ATP 0.01216 0.40652 6.07029
131 1LRH NLA 0.02236 0.41782 6.13497
132 5FPX GLY SER SER HIS HIS HIS HIS HIS 0.00387 0.43247 6.19469
133 4RT1 C2E 0.001257 0.4634 6.25
134 4CYI ATP 0.00002235 0.41609 6.38978
135 3GL0 HXX 0.02333 0.40928 6.70927
136 3DNT ATP 0.009147 0.40336 6.70927
137 3TPV ADE 0.01853 0.40113 6.70927
138 3I7V ATP 0.01617 0.41991 6.71642
139 3AJH BL3 0.008428 0.42384 6.85484
140 5DMZ ADP 0.000001255 0.59948 7.02875
141 4XMF HSM 0.0004834 0.51815 7.02875
142 4BJX 73B 0.02076 0.42376 7.02875
143 5WUU 7UU 0.03745 0.411 7.02875
144 4OFG PCG 0.02544 0.40737 7.02875
145 5U98 1KX 0.005037 0.40893 7.07071
146 1PVC ILE SER GLU VAL 0.01716 0.43061 7.14286
147 5JAX 6J7 0.002079 0.45296 7.40741
148 4OAV ACP 0.0000003551 0.63303 7.4392
149 3OYW TDG 0.006914 0.44957 7.46269
150 4ZYB 4SQ 0.008214 0.43208 7.46269
151 1W6P NDG GAL 0.0245 0.4188 7.46269
152 3TDV GDP 0.0001133 0.50796 7.51634
153 4FLP JQ1 0.01118 0.43882 7.56302
154 2OS2 OGA 0.01248 0.43696 7.66773
155 4WVO 3UZ 0.004092 0.40973 7.73481
156 1EHI ADP 0.008332 0.41715 7.98722
157 5TFZ 7BC 0.04024 0.40425 8
158 1N5S ADL 0.01212 0.41627 8.03571
159 4KAX 4IP 0.03609 0.41069 8.07453
160 3K5I ADP 0.009573 0.41121 8.18859
161 5IQD RIO 0.000197 0.4431 8.19672
162 5IQD GNP 0.0001809 0.4431 8.19672
163 5I35 ANP 0.00001012 0.56351 8.30671
164 2DTJ THR 0.02803 0.40881 8.42697
165 3AB4 THR 0.03758 0.40219 8.42697
166 1Y7P RIP 0.002735 0.42301 8.52018
167 2G30 ALA ALA PHE 0.004607 0.4057 8.52713
168 4UCC ZKW 0.02858 0.40223 8.58369
169 5A0U CHT 0.02933 0.41157 8.6262
170 3OCP CMP 0.006392 0.44187 8.63309
171 3HAV ATP 0.0001415 0.54482 8.69565
172 1OW4 2AN 0.03829 0.40177 9.30233
173 2W5P CL8 0.01599 0.43405 9.39597
174 1ZP9 ATP 0.00001908 0.55684 9.68992
175 1CBK ROI 0.01877 0.42716 10
176 3RE4 TO1 0.0000365 0.40555 10.0775
177 2XG5 EC5 0.003448 0.47523 10.0917
178 2XG5 EC2 0.003448 0.47523 10.0917
179 3PNA CMP 0.01263 0.43092 10.3896
180 2BKK ADP 0.0009499 0.47895 10.6061
181 3VPB ADP 0.000895 0.44287 10.7143
182 1XK5 TPG 0.03544 0.4118 10.7843
183 4ETZ C2E 0.01895 0.42162 11.1111
184 1OGX EQU 0.009479 0.42507 11.4504
185 1TZD ADP 0.003003 0.47306 11.5016
186 1W2D ADP 0.0007835 0.48853 11.6981
187 4QXB OGA 0.02742 0.41312 11.7647
188 4OUC 5ID 0.0000003174 0.64372 12.4601
189 5BWD FUM 0.002201 0.47922 12.4601
190 4D00 SIA GAL NAG 0.04483 0.40174 12.5683
191 5ML3 DL3 0.00206 0.40609 12.7517
192 3VY6 BGC BGC 0.04445 0.41237 12.766
193 4BKJ STI 0.000286 0.4058 13.4185
194 1I7M PUT 0.01822 0.41217 13.4328
195 3C1X CKK 0.00004994 0.50893 14.0575
196 2CDO GAL AAL GAL AAL GAL AAL 0.01265 0.4403 14.375
197 2IDO TMP 0.04119 0.40915 14.5161
198 5GZ9 ANP 0.0000004995 0.47914 14.7541
199 1VJY 460 0.00000007423 0.54952 15.016
200 4CRL C1I 0.000000666 0.53801 15.3355
201 2QX0 PH2 0.009165 0.44168 15.3355
202 4INW 1EY 0.008182 0.4209 15.7143
203 4XH0 ADP 0.000001645 0.64995 16.2939
204 4I94 ANP 0.0000008911 0.43965 16.2939
205 4NS0 PIO 0.0006114 0.50569 16.5414
206 4WVW SLT 0.001024 0.48474 16.6667
207 4RJD TFP 0.04593 0.40188 16.6667
208 2PZI AXX 0.00006848 0.536 16.9329
209 4Y0X ADP 0.000004897 0.42238 16.9329
210 4DFU QUE 0.03291 0.41288 17.0807
211 2Y6O 1N1 0.0000001514 0.49307 17.5258
212 4JR7 GNP 0.0000002459 0.463 17.8914
213 5C4L 4XR 0.0005914 0.41085 18.8498
214 4UYG 73B 0.04089 0.40717 19.1083
215 4O1P ANP 0.0000002291 0.46683 19.8083
216 5EOB 5QQ 0.0000003209 0.56518 20.1278
217 1QKQ MAN 0.01625 0.41584 20.4225
218 1TQP ATP 0.0001858 0.47533 20.4473
219 4IX4 ADP 0.00003798 0.4211 20.4473
220 4GYI ADP 0.00006148 0.53834 20.7668
221 1KTG AMP 0.02975 0.41747 21.0145
222 3VHE 42Q 0.0000001319 0.57956 21.0863
223 3PP0 03Q 0.00000121 0.55717 21.0863
224 4KBA 1QM 0.000004094 0.53063 21.0863
225 4ASE AV9 0.000004363 0.52951 21.0863
226 4AG8 AXI 0.0000007782 0.52684 21.0863
227 5W4W 9WG 0.0000004289 0.51882 21.0863
228 1U59 STU 0.00000001209 0.69384 21.2544
229 5UR1 YY9 0.0000004919 0.54414 21.865
230 3GQI ACP 0.00000001489 0.6896 22.0447
231 5MY8 RXZ 0.000003423 0.4664 22.0447
232 1JPA ANP 0.00001223 0.57377 22.1154
233 3PLS ANP 0.00000009662 0.66004 22.1477
234 4WW7 AMP 0.000003362 0.45074 22.4599
235 3H9R TAK 0.0000003454 0.67 22.6837
236 4OTH DRN 0.000000002839 0.69613 23.0032
237 5LXT ACP 0.01178 0.40138 23.0769
238 4WOV 3SM 0.000004114 0.59699 23.3227
239 5C03 AGS 0.00001112 0.55514 23.3227
240 5T8O 76Z 0.0000001059 0.63411 23.4957
241 4F9C 0SX 0.0000001494 0.46374 23.9617
242 5TO8 7FM 0.000001707 0.51958 24.1135
243 4GJ3 0XP 0.000000013 0.61281 24.1722
244 1Y57 MPZ 0.000001643 0.56832 24.6006
245 4E1Z 0MX 0.00000002006 0.65112 25.0859
246 5JGA 6KC 0.00000004979 0.58505 25.2396
247 4CSV STI 0.00001975 0.52159 25.8182
248 2XVD AS6 0.0000001526 0.58255 25.8278
249 5M06 ADP 0.000026 0.55027 26.4493
250 1OPK P16 0.000005021 0.51367 26.5176
251 4IDT T28 0.00000001927 0.48398 27.1565
252 4WB6 ATP 0.000001964 0.47677 27.1565
253 1ZY5 ANP 0.000007874 0.41786 27.3927
254 1RE8 BD2 0.00000002053 0.6001 27.476
255 3IDB ANP 0.0000008019 0.5818 27.476
256 2QCS ANP 0.000001004 0.4852 27.476
257 3FHI ANP 0.0000015 0.48063 27.476
258 4WB7 ATP 0.00002118 0.47522 27.476
259 5FBN 5WF 0.000001773 0.51013 27.6753
260 2GU8 796 0.000000001838 0.65222 27.7955
261 5USZ SKE 0.0000005428 0.56598 28.0277
262 4XLI 1N1 0.0000004779 0.62686 28.7313
263 5EKO N17 0.0001824 0.40113 29.393
264 5UOX 8GY 0.0000002975 0.60704 29.5203
265 4TWP AXI 0.000002917 0.46356 29.5203
266 1OUK 084 0.000001017 0.58141 29.7125
267 4LOO SB4 0.000001276 0.44536 29.7125
268 2R5T ANP 0.0000005887 0.59397 30.0319
269 1BYG STU 0.00000003419 0.69098 30.2158
270 5LXC 7AA 0.00000001492 0.47877 30.3514
271 4G17 0VN 0.00001262 0.40529 30.3514
272 2QLU ADE 0.0000005713 0.6885 30.5732
273 2CSN CKI 0.0002982 0.45471 30.6397
274 5UIU 8CG 0.0000002276 0.52331 31.9489
275 4IJP 1EH 0.000000003817 0.52709 32.2684
276 4Y85 499 0.000003678 0.429 32.2684
277 4IZY 1J2 0.000000003887 0.69863 32.5879
278 2HY0 306 0.00000004687 0.69405 32.5879
279 4UX9 ANP 0.000000008416 0.68355 32.5879
280 3TKI S25 0.00000009977 0.58319 32.5879
281 3TTI KBI 0.00000000844 0.63884 32.9073
282 3GNI ATP 0.0000001408 0.62855 32.9073
283 4FL3 ANP 0.0000001175 0.62484 32.9073
284 4WHZ 3NL 0.00000001372 0.52213 32.9073
285 3PTG 932 0.000000005615 0.46365 32.9073
286 4NST ADP 0.00000006615 0.65929 33.5463
287 4YZC STU 0.000000001024 0.63272 33.5463
288 3ORK AGS 0.000002464 0.5497 33.5463
289 3E8N ATP 0.0000008693 0.48328 33.5463
290 3E8N VRA 0.0000008693 0.48328 33.5463
291 4M69 ANP 0.00002424 0.52803 33.5689
292 3QCQ 3Q0 0.000000001951 0.43572 33.9744
293 5LVP ATP 0.00000003226 0.46403 34.0836
294 4CLI 5P8 0.0000000624 0.57888 34.1853
295 5EFQ ADP 0.0000000264 0.48626 34.1853
296 4EWH T77 0.0000001379 0.58996 34.5455
297 2X2M X2M 0.000000004796 0.52881 34.7134
298 4NFN 2KC 0.000004332 0.58111 34.8243
299 4Q5H ANP 0.00001014 0.55701 35.0575
300 3GC8 B45 0.0000000591 0.63799 35.1351
301 4EUU BX7 0.00000004656 0.61517 35.4633
302 5HCY 60D 0.0000001508 0.56469 35.4633
303 5HX8 66P 0.000000008336 0.64579 36.0927
304 2H8H H8H 0.0000002886 0.62935 36.1022
305 5VC5 96M 0.000000004695 0.56735 36.1022
306 4E93 GUI 0.0000003564 0.55282 36.1022
307 3RI1 3RH 0.00000003293 0.53407 36.1022
308 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.0000001322 0.46113 36.1022
309 2JDR L20 0.0000001322 0.46113 36.1022
310 4H3Q ANP 0.00000001725 0.52015 36.1878
311 5KO1 6UY 0.0000001655 0.64887 36.3958
312 3SXF BK5 0.000001789 0.5179 36.4217
313 4H3P ANP 0.0000000003942 0.76341 36.4641
314 1BHX ASP PHE GLU GLU ILE 0.002714 0.46092 36.6667
315 5LPZ ADP 0.0000002531 0.63202 36.7412
316 3PE2 E1B 0.0000009533 0.53794 36.7953
317 2PVN P63 0.000000008953 0.63133 36.9318
318 2Z7R STU 0.000000006312 0.68083 37.0607
319 5CEO 50D 0.000008228 0.42224 37.6667
320 5HVJ ANP 0.00000008115 0.72785 37.6997
321 3OFM 4B0 0.0000005934 0.4293 37.7143
322 2OO8 RAJ 0.0002199 0.48054 37.8549
323 3MVH WFE 0.000000009401 0.56806 38.0192
324 5LPB ADP 0.000001222 0.42213 38.1757
325 5JKG 6LF 0.000001084 0.52511 38.2637
326 4Y93 746 0.000002461 0.54972 38.3387
327 3LXK MI1 0.00000003129 0.54125 38.3387
328 4G31 0WH 0.000005895 0.50286 38.4615
329 5NKB 8ZT 0.0000000393 0.54027 38.5621
330 3PVW QRX 0.00000004042 0.61769 38.6581
331 3GC0 AMP 0.000001856 0.61426 38.6581
332 3UIM ANP 0.000001518 0.59561 38.6581
333 5UKL SIX 0.0000000631 0.52892 38.6581
334 3LXN MI1 0.000000009836 0.6805 38.9776
335 2B9I ADP 0.000000008521 0.70095 39.2971
336 3VRY B43 0.000001899 0.55441 39.2971
337 2B9H ADP 0.000000004643 0.51539 39.2971
338 2B9F ADP 0.000000003943 0.50714 39.2971
339 2B9J ADP 0.000000008568 0.49067 39.2971
340 4JDI ANP 0.0000004394 0.4682 39.2971
341 4U0I 0LI 0.00000509 0.51345 39.3651
342 3NW7 LGV 0.0000006492 0.54416 39.4137
343 3G5D 1N1 0.0000001186 0.58298 39.5105
344 3EKK GS2 0.000000009333 0.5881 39.7394
345 5HES 032 0.0000002034 0.48093 39.7394
346 3BU5 ATP 0.00000001697 0.49255 39.8693
347 3V8S 0HD 0.0000000007092 0.76204 39.9361
348 4L9I 8PR 0.00000001139 0.70441 39.9361
349 4BTK DTQ 0.000006899 0.43099 39.9361
350 3CY2 MB9 0.0000006039 0.58713 40.2556
351 4N70 2HX 0.0000009914 0.54007 40.2556
352 4OH4 ANP 0.0000001075 0.47764 40.2556
353 5DBX ANP 0.0000003959 0.42804 40.2556
354 3KRR DQX 0.00000001178 0.63061 40.339
355 4YZN 4K5 0.00000001213 0.66056 40.4181
356 3M2W L8I 0.00000003022 0.46349 40.4682
357 5BYZ 4WE 0.0000000008168 0.65886 40.5751
358 1XJD STU 0.00000005061 0.65643 40.5751
359 4P5Z Q7M 0.0000003952 0.52474 40.5751
360 4FG8 ATP 0.0000001283 0.4872 40.5751
361 4X7Q 3YR 0.00000002162 0.68202 40.7051
362 4AT3 LTI 0.00001009 0.50617 40.8027
363 2X4Z X4Z 0.00000006402 0.57074 40.8784
364 3BZ3 YAM 0.0000004957 0.45294 40.942
365 4XV1 904 0.000003998 0.49366 41.0959
366 2BPM 529 0.000000006396 0.52733 41.1003
367 3KRL KRL 0.0000006173 0.59306 41.2141
368 3TXO 07U 0.0000004709 0.44355 41.2141
369 4YMJ 4EJ 0.000001324 0.65459 41.4474
370 4NW6 2NS 0.0000001103 0.57203 41.4861
371 5TA6 79D 0.0000000192 0.62446 41.5335
372 4WNK 453 0.0000001103 0.53461 41.5335
373 5JFS 6K0 0.000001249 0.52613 41.5335
374 1Q8Y ADP 0.0000003154 0.47855 41.5335
375 3ALN ANP 0.000001274 0.46008 41.5335
376 1CM8 ANP 0.000001145 0.44246 41.5335
377 1Q8Y ADE 0.000002291 0.40517 41.5335
378 5U6C 7YS 0.000001023 0.58339 41.5873
379 2ZV2 609 0.0000002768 0.66498 41.6107
380 4NM5 ADP 0.00000002405 0.6477 41.853
381 3HZT J60 0.000001095 0.63445 41.853
382 3F7Z 34O 0.00000008378 0.47867 41.853
383 3KN5 ANP 0.00000003205 0.46305 41.853
384 3ZRM ZRM 0.000001917 0.44284 41.853
385 2XK9 XK9 0.001734 0.43661 41.853
386 4CFU 2WC 0.000000001918 0.75208 41.9142
387 3AQV TAK 0.00003647 0.40909 42.029
388 2WQN ADP 0.000003546 0.60021 42.1725
389 3FHR P4O 0.000001491 0.58907 42.1725
390 4BCM T7Z 0.00000006822 0.71845 42.1927
391 4BCQ TJF 0.000000171 0.44336 42.1927
392 4I6H 1C8 0.000006438 0.56625 42.2078
393 4BCN T9N 0.000000004996 0.7426 42.3333
394 3SLS ANP 0.0000008013 0.46769 42.4342
395 4KS7 X4Z 0.0000002435 0.6042 42.4658
396 4Y8D 49J 0.000000004458 0.71411 42.492
397 2PVF ACP 0.000000008814 0.70974 42.492
398 5BVE 4VG 0.0000000003977 0.68515 42.492
399 2JLD AG1 0.000000003345 0.62333 42.492
400 2RIO ADP 0.000000021 0.485 42.492
401 2XMY CDK 0.000000005066 0.64616 42.6175
402 5MJA 7O3 0.0000003873 0.44786 42.623
403 5LMK 6ZK 0.00000004027 0.46328 42.7609
404 3IGO ANP 0.0000001797 0.6167 42.8115
405 4U44 3D9 0.000001044 0.44893 42.8115
406 2WEL K88 0.00000003938 0.41143 42.8115
407 1K3A ACP 0.0000004922 0.64305 42.8571
408 3SXS PP2 0.0000004961 0.60396 42.9104
409 2A19 ANP 0.0000001285 0.68202 42.9577
410 5VCV 1N1 0.000000007608 0.66174 43.0868
411 4L3L 5FI 0.000000009655 0.56922 43.0921
412 5L8L ADP 0.0000000256 0.71783 43.1579
413 5G1X ADP 0.0000001009 0.65914 43.1579
414 4ITH RCM 0.01632 0.40073 43.1973
415 2OFV 242 0.0000003426 0.53966 43.3213
416 5DEY 59T 0.00000002322 0.49887 43.4343
417 4K33 ACP 0.0000001014 0.48135 43.4505
418 5LXM ADP 0.00000006019 0.66986 43.4629
419 4CQE CQE 0.000003316 0.44689 43.5252
420 5DRB 5FJ 0.00005536 0.4238 43.6426
421 1U5R ATP 0.000000003211 0.72078 43.77
422 5LI9 ACP 0.000000378 0.61639 43.77
423 4AUA 4AU 0.0000001457 0.46401 43.9739
424 4RFM 3P6 0.000001654 0.46053 43.985
425 5HQ0 LZ9 0.0000000006886 0.73242 44.0397
426 2YAB AMP 0.00000003329 0.66478 44.0895
427 5DH3 5BS 0.0000006334 0.59919 44.0895
428 5H2U 1N1 0.0000008416 0.6076 44.1948
429 5JZJ AN2 0.000000009691 0.70777 44.4444
430 2VN9 GVD 0.0000000421 0.43978 44.5183
431 5DA3 58V 0.00000004613 0.70475 44.5283
432 2F57 23D 0.0000005267 0.63298 44.7284
433 4QTB 38Z 0.0000000003375 0.61068 44.7284
434 4QMN DB8 0.000000107 0.55785 44.8387
435 4C2V YJA 0.000000000169 0.69223 44.9123
436 3C0G 3AM 0.00000002881 0.7046 45.0479
437 5IH9 6BF 0.00000005972 0.56695 45.0479
438 5LI1 ANP 0.000000142 0.48892 45.0479
439 3DLS ADP 0.0000007815 0.43475 45.0479
440 3SRV S19 0.000000005428 0.49955 45.1264
441 5AX9 4KT 0.0000005417 0.45814 45.1299
442 3GGF GVD 0.000000007509 0.48737 45.1827
443 4AU8 Z3R 0.00000002155 0.72164 45.2703
444 4WNP 3RJ 0.000000003576 0.74986 45.2962
445 1PHK ATP 0.000000005409 0.51204 45.302
446 3E7O 35F 0.00000007293 0.5788 45.3674
447 5EW9 5VC 0.0000005843 0.59137 45.3875
448 4USF 6UI 0.00002043 0.43893 45.3947
449 3DAK ANP 0.00000005242 0.46192 45.5172
450 2HK5 1BM 0.0000001046 0.48878 45.5556
451 5AWM ANP 0.0000001119 0.68508 45.6869
452 4BFM ANP 0.00000002616 0.66141 45.6869
453 4F4P 0SB 0.000002009 0.53937 45.7875
454 1V0O INR 0.000000003439 0.70999 45.8333
455 4C2W ANP 0.000000008798 0.46245 45.8781
456 1UNH IXM 0.000000001578 0.7676 45.8904
457 3O0G 3O0 0.00000001051 0.4906 45.8904
458 3E5A VX6 0.0000008607 0.56876 45.8955
459 4BHN BH9 0.0000003347 0.61164 46.0064
460 2WEI VGG 0.0000003191 0.6436 46.3415
461 5EYK 5U5 0.000000006956 0.64222 46.7391
462 2YAK OSV 0.000000002698 0.64536 47.0175
463 5A6N U7E 0.00000003309 0.49368 47.7032
464 2VZ6 FEF 0.0000007365 0.6343 47.9233
465 4A4X JUP 0.000000234 0.50728 48.0287
466 2V7O DRN 0.00000000932 0.45014 48.8818
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