Receptor
PDB id Resolution Class Description Source Keywords
5AMC 1.65 Å EC: 3.4.15.1 CRYSTAL STRUCTURE OF THE ANGIOTENSIN-1 CONVERTING ENZYME N-D COMPLEX WITH AMYLOID-BETA FLUOROGENIC FRAGMENT 4-10 HOMO SAPIENS HYDROLASE ANGIOTENSIN-CONVERTING ENZYME METALLOPROTEASE ABETA
Ref.: THE KINETIC AND STRUCTURAL CHARACTERISATION OF AMYL METABOLISM BY HUMAN ANGIOTENSIN-1- CONVERTING ENZYM FEBS J. V. 283 1060 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PEG A:1620;
B:1620;
A:1622;
B:1623;
B:1622;
A:1621;
 Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
 none;
none;
none;
none;
none;
none;
 submit data
106.12 C4 H10 O3 C(COC...
GLY NIY A:906;
B:906;
 Valid;
Valid;
 none;
none;
 submit data
285.256 n/a O=C([...
NAG NAG G:1;
D:1;
 Invalid;
Invalid;
 none;
none;
 submit data
408.404 n/a O=C(N...
P6G B:1621;
 Invalid;
 none;
 submit data
282.331 C12 H26 O7 C(COC...
PG4 B:1611;
 Invalid;
 none;
 submit data
194.226 C8 H18 O5 C(COC...
NAG FUC C:1;
F:1;
 Invalid;
Invalid;
 none;
none;
 submit data
367.351 n/a O=C(N...
CL B:1612;
A:1611;
 Invalid;
Invalid;
 none;
none;
 submit data
35.453 Cl [Cl-]
NAG NAG BMA H:1;
 Invalid;
 none;
 submit data
570.545 n/a O=C(N...
ZN A:1001;
B:1001;
 Part of Protein;
Part of Protein;
 none;
none;
 submit data
65.409 Zn [Zn+2...
FUC NAG BMA NAG E:4;
 Invalid;
 none;
 submit data
n/a n/a
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5AMC 1.65 Å EC: 3.4.15.1 CRYSTAL STRUCTURE OF THE ANGIOTENSIN-1 CONVERTING ENZYME N-D COMPLEX WITH AMYLOID-BETA FLUOROGENIC FRAGMENT 4-10 HOMO SAPIENS HYDROLASE ANGIOTENSIN-CONVERTING ENZYME METALLOPROTEASE ABETA
Ref.: THE KINETIC AND STRUCTURAL CHARACTERISATION OF AMYL METABOLISM BY HUMAN ANGIOTENSIN-1- CONVERTING ENZYM FEBS J. V. 283 1060 2016
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 5AMC - GLY NIY n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 5AMC - GLY NIY n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 5AMC - GLY NIY n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: GLY NIY; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 GLY NIY 1 1
2 NIY 0.52459 0.810345
3 NPA 0.45 0.754386
Similar Ligands (3D)
Ligand no: 1; Ligand: GLY NIY; Similar ligands found: 11
No: Ligand Similarity coefficient
1 6U5 0.8934
2 9PP 0.8847
3 X2M 0.8730
4 7W7 0.8659
5 3NF 0.8654
6 GLY TYR 0.8645
7 D5M 0.8614
8 4X2 0.8599
9 BZS 0.8594
10 0XR 0.8568
11 IM5 0.8562
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5AMC; Ligand: GLY NIY; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 5amc.bio2) has 15 residues
No: Leader PDB Ligand Sequence Similarity
APoc FAQ
Feedback