Receptor
PDB id Resolution Class Description Source Keywords
5AHO 2.16 Å EC: 3.1.-.- CRYSTAL STRUCTURE OF HUMAN 5' EXONUCLEASE APOLLO HOMO SAPIENS HYDROLASE DNA REPAIR METALLO-BETA-LACTAMASE DCLRE1B
Ref.: THE STRUCTURES OF THE SNM1A AND SNM1B/APOLLO NUCLEA DOMAINS REVEAL A POTENTIAL BASIS FOR THEIR DISTINCT PROCESSING ACTIVITIES. NUCLEIC ACIDS RES. V. 43 11047 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EDO A:1316;
A:1315;
A:1317;
A:1314;
A:1318;
A:1323;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
ZN A:1321;
A:1320;
Part of Protein;
Part of Protein;
none;
none;
submit data
65.409 Zn [Zn+2...
TLA A:1319;
A:1322;
Valid;
Valid;
none;
none;
submit data
150.087 C4 H6 O6 [C@@H...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5AHO 2.16 Å EC: 3.1.-.- CRYSTAL STRUCTURE OF HUMAN 5' EXONUCLEASE APOLLO HOMO SAPIENS HYDROLASE DNA REPAIR METALLO-BETA-LACTAMASE DCLRE1B
Ref.: THE STRUCTURES OF THE SNM1A AND SNM1B/APOLLO NUCLEA DOMAINS REVEAL A POTENTIAL BASIS FOR THEIR DISTINCT PROCESSING ACTIVITIES. NUCLEIC ACIDS RES. V. 43 11047 2015
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 23 families.
1 5AHO - TLA C4 H6 O6 [C@@H]([C@....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 17 families.
1 5AHO - TLA C4 H6 O6 [C@@H]([C@....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 14 families.
1 5AHO - TLA C4 H6 O6 [C@@H]([C@....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: TLA; Similar ligands found: 13
No: Ligand ECFP6 Tc MDL keys Tc
1 SRT 1 1
2 TAR 1 1
3 TLA 1 1
4 LGT 0.588235 1
5 GAE 0.588235 1
6 RAT 0.588235 1
7 2OP 0.5 0.611111
8 LAC 0.5 0.611111
9 IPM 0.47619 0.8
10 LFC 0.434783 0.777778
11 ICT 0.416667 0.727273
12 DXX 0.411765 0.777778
13 MAK 0.4 0.941176
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5AHO; Ligand: TLA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 5aho.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 5AHO; Ligand: TLA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 5aho.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
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