Receptor
PDB id Resolution Class Description Source Keywords
4u73 1.8 Å EC: 3.4.11.18 HSMETAP(F309M) IN COMPLEX WITH (AMINO(PHENYL)METHYL)PHOSPHON HOMO SAPIENS HYDROLASE
Ref.: IDENTIFICATION OF THE MOLECULAR BASIS OF INHIBITOR SELECTIVITY BETWEEN THE HUMAN AND STREPTOCOCCAL TYP METHIONINE AMINOPEPTIDASES J.MED.CHEM. V. 58 2350 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
K A:403;
 Part of Protein;
 none;
 submit data
39.098 K [K+]
CO A:402;
A:401;
 Part of Protein;
Part of Protein;
 none;
none;
 submit data
58.933 Co [Co+2...
Q02 A:404;
 Valid;
 none;
 Ki = 6.6 uM
187.133 C7 H10 N O3 P c1ccc...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4IKR 1.78 Å EC: 3.4.11.18 CRYSTAL STRUCTURE OF TYPE 1 HUMAN METHIONINE AMINOPEPTIDASE WITH 2-(4-(5-CHLORO-6-METHYL-2-(PYRIDIN-2-YL)PYRIMIDIN-4-YLP IPERAZIN-1-YL)ETHANOL HOMO SAPIENS PITA-BREAD FOLD AMINOPEPTIDASE RIBOSOME HYDROLASE
Ref.: IDENTIFICATION, BIOCHEMICAL AND STRUCTURAL EVALUATI SPECIES-SPECIFIC INHIBITORS AGAINST TYPE I METHIONI AMINOPEPTIDASES J.MED.CHEM. V. 56 5295 2013
Members (20)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 2NQ6 ic50 = 1.5 uM HM4 C14 H16 N4 O3 S CC(C)(C)OC....
2 4U69 Ki = 54.8 uM Q07 C6 H16 N O3 P CCC[C@H](C....
3 2G6P ic50 = 0.6 uM HM2 C18 H17 Cl N4 Cc1c(c(nc(....
4 4U73 Ki = 6.6 uM Q02 C7 H10 N O3 P c1ccc(cc1)....
5 4IKT ic50 = 0.67 uM TFV C18 H16 Cl F3 N6 Cc1c(c(nc(....
6 4U6Z Ki = 3.9 uM Q07 C6 H16 N O3 P CCC[C@H](C....
7 4U70 Ki = 9.5 uM Q04 C8 H18 N O3 P C1CCC(CC1)....
8 4FLI ic50 = 3.59 uM Y16 C14 H26 N2 O6 CC(C)(C)/C....
9 4U6C Ki = 9.9 uM Q06 C8 H18 N O3 P C1CCC(C1)C....
10 4IKR ic50 = 0.59 uM PVP C16 H20 Cl N5 O Cc1c(c(nc(....
11 4FLK ic50 = 5.58 uM Y10 C21 H31 N O5 CC(C)(C)/C....
12 4IKU ic50 = 1.79 uM SHX C19 H18 Cl N5 O Cc1c(c(nc(....
13 2NQ7 ic50 = 2.9 uM HM5 C14 H16 N4 O2 S CC(C)(C)C(....
14 4FLL ic50 = 5.14 uM YZ6 C25 H35 N O6 CC(C)(C)/C....
15 4U71 Ki = 6 uM Q03 C7 H16 N O3 P C1CCC(CC1)....
16 4HXX - 1AY C28 H29 Cl2 N5 Cc1c(c(nc(....
17 4IKS ic50 = 7.23 uM TFD C18 H16 Cl F3 N6 Cc1c(c(nc(....
18 4U6E Ki = 111.6 uM Q02 C7 H10 N O3 P c1ccc(cc1)....
19 4U1B Ki = 4.9 uM Q08 C8 H20 N O3 P CCCC(CCC)[....
20 4FLJ ic50 = 7.45 uM Y08 C22 H38 N2 O6 CC(C)(C)/C....
70% Homology Family (21)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 2NQ6 ic50 = 1.5 uM HM4 C14 H16 N4 O3 S CC(C)(C)OC....
2 4U69 Ki = 54.8 uM Q07 C6 H16 N O3 P CCC[C@H](C....
3 2G6P ic50 = 0.6 uM HM2 C18 H17 Cl N4 Cc1c(c(nc(....
4 4U73 Ki = 6.6 uM Q02 C7 H10 N O3 P c1ccc(cc1)....
5 4IKT ic50 = 0.67 uM TFV C18 H16 Cl F3 N6 Cc1c(c(nc(....
6 4U6Z Ki = 3.9 uM Q07 C6 H16 N O3 P CCC[C@H](C....
7 4U70 Ki = 9.5 uM Q04 C8 H18 N O3 P C1CCC(CC1)....
8 4FLI ic50 = 3.59 uM Y16 C14 H26 N2 O6 CC(C)(C)/C....
9 4U6C Ki = 9.9 uM Q06 C8 H18 N O3 P C1CCC(C1)C....
10 4IKR ic50 = 0.59 uM PVP C16 H20 Cl N5 O Cc1c(c(nc(....
11 4FLK ic50 = 5.58 uM Y10 C21 H31 N O5 CC(C)(C)/C....
12 4IKU ic50 = 1.79 uM SHX C19 H18 Cl N5 O Cc1c(c(nc(....
13 2NQ7 ic50 = 2.9 uM HM5 C14 H16 N4 O2 S CC(C)(C)C(....
14 4FLL ic50 = 5.14 uM YZ6 C25 H35 N O6 CC(C)(C)/C....
15 4U71 Ki = 6 uM Q03 C7 H16 N O3 P C1CCC(CC1)....
16 4HXX - 1AY C28 H29 Cl2 N5 Cc1c(c(nc(....
17 4IKS ic50 = 7.23 uM TFD C18 H16 Cl F3 N6 Cc1c(c(nc(....
18 4U6E Ki = 111.6 uM Q02 C7 H10 N O3 P c1ccc(cc1)....
19 4U1B Ki = 4.9 uM Q08 C8 H20 N O3 P CCCC(CCC)[....
20 4FLJ ic50 = 7.45 uM Y08 C22 H38 N2 O6 CC(C)(C)/C....
21 4IU6 - FZ1 C24 H23 N5 O COc1ccc(cc....
50% Homology Family (69)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 2NQ6 ic50 = 1.5 uM HM4 C14 H16 N4 O3 S CC(C)(C)OC....
2 4U69 Ki = 54.8 uM Q07 C6 H16 N O3 P CCC[C@H](C....
3 2G6P ic50 = 0.6 uM HM2 C18 H17 Cl N4 Cc1c(c(nc(....
4 4U73 Ki = 6.6 uM Q02 C7 H10 N O3 P c1ccc(cc1)....
5 4IKT ic50 = 0.67 uM TFV C18 H16 Cl F3 N6 Cc1c(c(nc(....
6 4U6Z Ki = 3.9 uM Q07 C6 H16 N O3 P CCC[C@H](C....
7 4U70 Ki = 9.5 uM Q04 C8 H18 N O3 P C1CCC(CC1)....
8 4FLI ic50 = 3.59 uM Y16 C14 H26 N2 O6 CC(C)(C)/C....
9 4U6C Ki = 9.9 uM Q06 C8 H18 N O3 P C1CCC(C1)C....
10 4IKR ic50 = 0.59 uM PVP C16 H20 Cl N5 O Cc1c(c(nc(....
11 4FLK ic50 = 5.58 uM Y10 C21 H31 N O5 CC(C)(C)/C....
12 4IKU ic50 = 1.79 uM SHX C19 H18 Cl N5 O Cc1c(c(nc(....
13 2NQ7 ic50 = 2.9 uM HM5 C14 H16 N4 O2 S CC(C)(C)C(....
14 4FLL ic50 = 5.14 uM YZ6 C25 H35 N O6 CC(C)(C)/C....
15 4U71 Ki = 6 uM Q03 C7 H16 N O3 P C1CCC(CC1)....
16 4HXX - 1AY C28 H29 Cl2 N5 Cc1c(c(nc(....
17 4IKS ic50 = 7.23 uM TFD C18 H16 Cl F3 N6 Cc1c(c(nc(....
18 4U6E Ki = 111.6 uM Q02 C7 H10 N O3 P c1ccc(cc1)....
19 4U1B Ki = 4.9 uM Q08 C8 H20 N O3 P CCCC(CCC)[....
20 4FLJ ic50 = 7.45 uM Y08 C22 H38 N2 O6 CC(C)(C)/C....
21 2GG0 ic50 = 1.7 uM U11 C16 H20 F3 N3 O5 C[C@@H](C(....
22 1YVM Ki = 0.4 uM TMG C10 H7 N3 S c1ccc2c(c1....
23 2GU6 - NLP C5 H14 N O3 P CCCC[C@H](....
24 2Q95 ic50 = 1.6 uM A05 C11 H6 Cl N O5 c1cc(c(cc1....
25 2GG8 ic50 = 25 uM U15 C20 H31 N3 O5 Cc1ccc(cc1....
26 2GTX - NLP C5 H14 N O3 P CCCC[C@H](....
27 2EVC ic50 = 0.29 uM FC3 C12 H7 F3 O3 c1ccc(c(c1....
28 4A6W ic50 = 1.9 uM 5C1 C10 H7 Cl N2 O3 c1ccc(c(c1....
29 2GG3 ic50 = 0.58 uM U13 C9 H7 F N6 [H]/N=C/1C....
30 3D27 ic50 = 55.7 uM W29 C12 H12 O2 S CCc1ccsc1c....
31 2GG7 ic50 = 1.75 uM U14 C10 H8 N6 O2 [H]/N=C1/C....
32 2GU5 - NLP C5 H14 N O3 P CCCC[C@H](....
33 1XNZ ic50 = 0.24 uM FCD C11 H7 Cl O3 c1ccc(c(c1....
34 4A6V ic50 = 1.9 uM IKY C11 H7 F3 N2 O3 c1ccc(c(c1....
35 1C21 - MET C5 H11 N O2 S CSCC[C@@H]....
36 2Q92 ic50 = 1.1 uM B23 C11 H7 N O5 c1ccc(c(c1....
37 1C27 - NLP C5 H14 N O3 P CCCC[C@H](....
38 1C24 - MPJ C4 H12 N O2 P S CSCC[C@H](....
39 2EVO ic50 = 0.067 uM CT0 C10 H13 N3 O2 S c1csc(n1)N....
40 2P99 ic50 = 1.16 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
41 2GG9 ic50 = 3.5 uM U16 C22 H35 N3 O5 CC(C)C[C@H....
42 2Q94 ic50 = 0.37 uM A04 C12 H7 F3 O4 c1ccc(c(c1....
43 2P98 ic50 = 0.64 uM YE7 C12 H10 N4 O c1ccc2c(c1....
44 2GGB ic50 = 12 uM U17 C17 H33 N3 O6 CCCC[C@H](....
45 2EVM ic50 = 0.693 uM FC2 C11 H6 Cl2 O3 c1cc(c(cc1....
46 1C22 - MF3 C5 H8 F3 N O2 S C(CSC(F)(F....
47 1C23 - MPH C4 H12 N O3 P S CSCC[C@H](....
48 2Q96 ic50 = 1.2 uM A18 C12 H9 Cl O3 c1ccc(c(c1....
49 2BB7 ic50 = 2.14 uM QMS C10 H10 N2 O2 S CS(=O)(=O)....
50 2GG2 ic50 = 0.25 uM U12 C10 H7 F3 N6 c1cc(cc(c1....
51 2GGC - MET C5 H11 N O2 S CSCC[C@@H]....
52 2GU4 - NLP C5 H14 N O3 P CCCC[C@H](....
53 2Q93 ic50 = 0.56 uM B21 C12 H10 O4 COc1ccccc1....
54 2GG5 ic50 = 0.25 uM U19 C10 H7 F3 N6 [H]/N=C1/C....
55 3MAT - AHH ALA LEU VAL 0A9 n/a n/a
56 2P9A ic50 = 6.56 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
57 4IU6 - FZ1 C24 H23 N5 O COc1ccc(cc....
58 1QXZ ic50 = 19 uM M3C C8 H14 N2 O2 S2 CSCC[C@@H]....
59 1QXY ic50 = 16 uM M2C C10 H16 N2 O2 S CSCC[C@@H]....
60 1QXW ic50 = 7 uM M1C C10 H22 N2 O2 CCCC[C@@H]....
61 3IU9 ic50 = 0.24 uM T07 C9 H8 Cl2 N4 S c1cc(c(cc1....
62 3IU7 ic50 = 16 uM FCD C11 H7 Cl O3 c1ccc(c(c1....
63 3PKE - Y10 C21 H31 N O5 CC(C)(C)/C....
64 3PKB ic50 = 0.62 uM Y16 C14 H26 N2 O6 CC(C)(C)/C....
65 3PKA ic50 = 0.54 uM Y02 C23 H37 N O6 Cc1cc(c(c(....
66 3PKC ic50 = 0.96 uM Y08 C22 H38 N2 O6 CC(C)(C)/C....
67 3IU8 ic50 = 0.58 uM T03 C9 H8 F N3 S c1cc(ccc1C....
68 3PKD ic50 = 0.76 uM Y10 C21 H31 N O5 CC(C)(C)/C....
69 1YJ3 - MET C5 H11 N O2 S CSCC[C@@H]....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: Q02; Similar ligands found: 5
No: Ligand ECFP6 Tc MDL keys Tc
1 Q02 1 1
2 787 0.515152 0.633333
3 1OS 0.45 0.8125
4 1OU 0.418605 0.722222
5 1OT 0.404255 0.604651
Similar Ligands (3D)
Ligand no: 1; Ligand: Q02; Similar ligands found: 861
No: Ligand Similarity coefficient
1 Q03 0.9754
2 B85 0.9593
3 HPS 0.9570
4 173 0.9547
5 8OZ 0.9462
6 9RH 0.9426
7 SMN 0.9423
8 9RW 0.9396
9 PMF 0.9345
10 CXP 0.9339
11 HCI 0.9319
12 PBA 0.9316
13 GWM 0.9308
14 MAJ 0.9301
15 QMP 0.9300
16 DBX 0.9297
17 ICO 0.9296
18 SYC 0.9293
19 JZA 0.9267
20 23J 0.9251
21 RMN 0.9250
22 A29 0.9248
23 4SX 0.9245
24 NDH 0.9242
25 SEP 0.9241
26 1L5 0.9240
27 ISZ 0.9238
28 PPY 0.9236
29 5RN 0.9233
30 EKZ 0.9229
31 NIZ 0.9225
32 3YP 0.9224
33 0HO 0.9220
34 92K 0.9220
35 6M4 0.9214
36 5NI 0.9211
37 KBB 0.9208
38 0HN 0.9207
39 HFA 0.9207
40 2ZM 0.9205
41 E7Z 0.9204
42 0OC 0.9203
43 CFI 0.9201
44 3NY 0.9198
45 MNN 0.9195
46 CTL 0.9193
47 PAC 0.9190
48 M2K 0.9190
49 1F1 0.9186
50 APG 0.9182
51 FK8 0.9181
52 GRO 0.9174
53 MWP 0.9173
54 PHU 0.9172
55 6NT 0.9167
56 X0V 0.9165
57 1DJ 0.9163
58 PHE 0.9161
59 LSA 0.9157
60 EYK 0.9155
61 BHO 0.9147
62 6NI 0.9147
63 NCT 0.9144
64 IFP 0.9143
65 I1E 0.9138
66 TTL 0.9138
67 TSU 0.9138
68 JAW 0.9136
69 FBV 0.9135
70 SAF 0.9133
71 QY9 0.9132
72 FBS 0.9131
73 3A9 0.9129
74 SAN 0.9129
75 K6H 0.9128
76 4P5 0.9124
77 M74 0.9124
78 2HU 0.9121
79 I3A 0.9121
80 MES 0.9121
81 61M 0.9120
82 PO6 0.9119
83 ABI 0.9118
84 CCB 0.9117
85 M3H 0.9117
86 I4B 0.9116
87 NFA 0.9111
88 OMD 0.9107
89 K5W 0.9107
90 2O6 0.9106
91 IAC 0.9103
92 091 0.9102
93 M4T 0.9102
94 HIS 0.9098
95 5NS 0.9097
96 269 0.9097
97 PPT 0.9097
98 MXN 0.9096
99 A3M 0.9095
100 AKG 0.9094
101 5RO 0.9094
102 HHH 0.9089
103 OGA 0.9088
104 FBW 0.9087
105 5OB 0.9084
106 4J8 0.9084
107 FF3 0.9084
108 S8V 0.9084
109 URO 0.9083
110 8ZE 0.9079
111 ICB 0.9078
112 HC4 0.9075
113 TYL 0.9075
114 9FL 0.9075
115 GPF 0.9074
116 MHK 0.9069
117 BZ3 0.9068
118 268 0.9055
119 C2Y 0.9054
120 HA5 0.9053
121 0JD 0.9051
122 BCU 0.9050
123 15N 0.9050
124 ESP 0.9050
125 9CA 0.9050
126 EVF 0.9046
127 92P 0.9045
128 1IT 0.9042
129 DYT 0.9041
130 COU 0.9041
131 PD2 0.9041
132 E1P 0.9040
133 3PG 0.9039
134 B3U 0.9039
135 J9Q 0.9036
136 BNL 0.9035
137 4TU 0.9034
138 36E 0.9034
139 AHN 0.9032
140 5XB 0.9032
141 DOB 0.9029
142 4FH 0.9029
143 PMB 0.9028
144 E1T 0.9027
145 EDR 0.9026
146 XCZ 0.9023
147 BZJ 0.9022
148 EA1 0.9022
149 NNO 0.9021
150 2LY 0.9019
151 OCH 0.9019
152 INO 0.9018
153 K7M 0.9016
154 DPN 0.9016
155 BHA 0.9016
156 XBT 0.9016
157 PIM 0.9015
158 JB8 0.9014
159 M4E 0.9011
160 H42 0.9010
161 4HC 0.9009
162 FHC 0.9007
163 JB5 0.9007
164 03V 0.9006
165 AMS 0.9006
166 AAS 0.9006
167 R9M 0.9006
168 JDN 0.9005
169 GVG 0.9004
170 FHB 0.9003
171 4JQ 0.9001
172 PDC 0.9000
173 TYE 0.9000
174 HA7 0.9000
175 GOJ 0.8999
176 97T 0.8999
177 KJH 0.8998
178 HF2 0.8998
179 9ZE 0.8995
180 PIY 0.8995
181 J0Z 0.8995
182 6FZ 0.8995
183 SLS 0.8993
184 SXS 0.8993
185 NVU 0.8992
186 PJW 0.8991
187 GLO 0.8991
188 0BP 0.8990
189 2HC 0.8989
190 12Q 0.8988
191 DHB 0.8986
192 BZ2 0.8986
193 ONL 0.8985
194 51R 0.8985
195 4Z4 0.8985
196 7W1 0.8984
197 5QX 0.8983
198 GUA 0.8983
199 8XL 0.8982
200 5CU 0.8981
201 1SA 0.8979
202 2PG 0.8978
203 3FH 0.8976
204 152 0.8975
205 4A3 0.8975
206 2BG 0.8975
207 FEH 0.8974
208 93K 0.8972
209 BNF 0.8972
210 LZ2 0.8970
211 IPB 0.8969
212 FB2 0.8969
213 7CT 0.8969
214 FA0 0.8968
215 BEA 0.8967
216 N2I 0.8966
217 ES5 0.8965
218 P9P 0.8964
219 CH9 0.8964
220 ABV 0.8964
221 R2P 0.8964
222 FCR 0.8964
223 GTQ 0.8963
224 2AQ 0.8962
225 ESX 0.8962
226 TT4 0.8961
227 GLN 0.8961
228 5XC 0.8961
229 GLU 0.8960
230 4FS 0.8959
231 DHY 0.8957
232 RAT 0.8956
233 FBM 0.8956
234 LT2 0.8953
235 9TW 0.8952
236 3QM 0.8952
237 A09 0.8952
238 SRT 0.8952
239 QUS 0.8952
240 T9G 0.8949
241 GBN 0.8949
242 HDH 0.8949
243 FBB 0.8948
244 FB1 0.8948
245 PLU 0.8946
246 3PF 0.8945
247 52C 0.8944
248 PHB 0.8942
249 M45 0.8941
250 FAN 0.8941
251 SYM 0.8940
252 4NC 0.8940
253 9ON 0.8939
254 F9P 0.8939
255 HQD 0.8938
256 SHI 0.8936
257 7MK 0.8936
258 1XA 0.8934
259 HQJ 0.8932
260 0N7 0.8931
261 R9S 0.8930
262 2HG 0.8930
263 TIH 0.8929
264 3LR 0.8929
265 SOR 0.8928
266 4JT 0.8927
267 FBT 0.8927
268 EN1 0.8925
269 SKM 0.8924
270 3SL 0.8923
271 XM0 0.8923
272 S2P 0.8922
273 KVP 0.8922
274 NPO 0.8921
275 YZM 0.8921
276 DS0 0.8920
277 JF6 0.8920
278 FBJ 0.8920
279 TZL 0.8918
280 4YO 0.8916
281 IOS 0.8916
282 YPN 0.8916
283 J9W 0.8915
284 5QY 0.8915
285 ODO 0.8914
286 5NU 0.8914
287 5WV 0.8913
288 MSR 0.8910
289 SNU 0.8908
290 DGN 0.8908
291 4VY 0.8907
292 HSO 0.8907
293 HQT 0.8905
294 BZX 0.8905
295 54D 0.8903
296 DE5 0.8903
297 TTY 0.8902
298 DHI 0.8902
299 MUC 0.8902
300 K2T 0.8900
301 791 0.8899
302 LNR 0.8899
303 XRX 0.8898
304 EXD 0.8897
305 MR1 0.8897
306 SPA 0.8897
307 4M0 0.8896
308 XXG 0.8893
309 L5V 0.8893
310 TIU 0.8893
311 HDL 0.8892
312 7HQ 0.8892
313 D48 0.8892
314 F1A 0.8892
315 KJU 0.8891
316 5RG 0.8891
317 2C2 0.8890
318 TSR 0.8890
319 3BU 0.8888
320 QSB 0.8888
321 MYJ 0.8888
322 8U3 0.8888
323 2FY 0.8888
324 GPJ 0.8887
325 B09 0.8887
326 IWT 0.8886
327 A9P 0.8886
328 Q07 0.8885
329 HG3 0.8885
330 N2Z 0.8885
331 URS 0.8884
332 HPV 0.8884
333 TSS 0.8884
334 9FE 0.8884
335 ASO 0.8884
336 SYV 0.8883
337 56D 0.8882
338 XIY 0.8882
339 GCB 0.8882
340 G3H 0.8881
341 263 0.8880
342 AEG 0.8880
343 1M2 0.8880
344 SE2 0.8880
345 1X4 0.8879
346 JAE 0.8879
347 PAB 0.8879
348 S2G 0.8878
349 SKF 0.8878
350 E4P 0.8878
351 4WL 0.8878
352 PEY 0.8877
353 FOM 0.8876
354 EVA 0.8876
355 0LH 0.8875
356 J5I 0.8875
357 M5E 0.8874
358 94W 0.8873
359 8G0 0.8873
360 VNL 0.8873
361 XDE 0.8871
362 ET2 0.8871
363 GGL 0.8870
364 2IT 0.8870
365 2HO 0.8870
366 MS9 0.8868
367 J9N 0.8868
368 JLZ 0.8866
369 XX2 0.8863
370 HIO 0.8863
371 URC 0.8862
372 54G 0.8862
373 TGX 0.8862
374 4PN 0.8862
375 G3E 0.8862
376 4MU 0.8862
377 K34 0.8860
378 264 0.8860
379 F05 0.8860
380 KDG 0.8859
381 13P 0.8858
382 ISN 0.8856
383 OK7 0.8855
384 0P6 0.8853
385 SRO 0.8853
386 DAL DAL 0.8853
387 AX7 0.8853
388 KKN 0.8853
389 069 0.8852
390 MQN 0.8851
391 PBZ 0.8850
392 ESI 0.8850
393 CPZ 0.8850
394 QX4 0.8849
395 5H1 0.8849
396 OA3 0.8847
397 HY1 0.8847
398 9TZ 0.8845
399 67X 0.8845
400 BDP 0.8844
401 R8V 0.8843
402 PEP 0.8843
403 SHA 0.8843
404 7N0 0.8842
405 RUY 0.8841
406 UFV 0.8841
407 DQU 0.8840
408 F31 0.8839
409 1P8 0.8838
410 GJZ 0.8838
411 6KT 0.8837
412 LFC 0.8837
413 6TZ 0.8837
414 XRS 0.8837
415 SD4 0.8836
416 1VK 0.8836
417 GCU 0.8835
418 J9T 0.8834
419 AC6 0.8834
420 CHB 0.8833
421 RM1 0.8832
422 L99 0.8831
423 AZ9 0.8831
424 FA1 0.8830
425 MLT 0.8830
426 14O 0.8829
427 CN0 0.8829
428 BGC 0.8828
429 PGH 0.8828
430 8WO 0.8828
431 0F9 0.8828
432 A5E 0.8828
433 7W4 0.8827
434 PZI 0.8827
435 4MA 0.8827
436 5LD 0.8826
437 B40 0.8825
438 DNF 0.8824
439 0TU 0.8824
440 HX4 0.8824
441 7VS 0.8823
442 2ZQ 0.8823
443 SAL 0.8823
444 42A 0.8823
445 7ZE 0.8822
446 3HM 0.8821
447 Z5P 0.8821
448 0FK 0.8819
449 OVM 0.8819
450 PE0 0.8819
451 R20 0.8818
452 4ZA 0.8817
453 IV2 0.8817
454 5M0 0.8817
455 DGL 0.8817
456 I38 0.8816
457 5MI 0.8816
458 F60 0.8816
459 ES7 0.8816
460 Q6T 0.8815
461 M1Q 0.8815
462 APS 0.8815
463 KTA 0.8815
464 3MB 0.8815
465 CWJ 0.8814
466 M4S 0.8813
467 2HQ 0.8813
468 8CM 0.8813
469 KDV 0.8812
470 717 0.8812
471 SPV 0.8811
472 PKU 0.8810
473 N8Y 0.8810
474 GCO 0.8809
475 5DL 0.8809
476 IHB 0.8809
477 ES2 0.8808
478 LMR 0.8807
479 B62 0.8807
480 TYR 0.8806
481 OTR 0.8806
482 M72 0.8805
483 1WC 0.8805
484 3OC 0.8804
485 JRB 0.8804
486 UA5 0.8803
487 BE2 0.8803
488 DHK 0.8802
489 NLA 0.8802
490 6M9 0.8802
491 AZ8 0.8802
492 8HC 0.8800
493 HGA 0.8798
494 ZBT 0.8798
495 HNL 0.8798
496 ISA 0.8798
497 HQ9 0.8798
498 AJ2 0.8797
499 2K4 0.8795
500 DTY 0.8794
501 3CR 0.8794
502 3SK 0.8794
503 1Y6 0.8793
504 KOJ 0.8793
505 JKE 0.8792
506 GZ3 0.8792
507 K97 0.8792
508 S0E 0.8792
509 AFS 0.8791
510 5MB 0.8791
511 P58 0.8791
512 AQO 0.8791
513 86J 0.8789
514 QBS 0.8789
515 NLP 0.8789
516 GLC 0.8788
517 E0O 0.8788
518 AOT 0.8787
519 AZM 0.8787
520 GZQ 0.8787
521 F9Y 0.8786
522 HHI 0.8786
523 CS2 0.8784
524 P72 0.8783
525 JA8 0.8780
526 7MU 0.8780
527 5VL 0.8780
528 Z82 0.8780
529 MUA 0.8779
530 S24 0.8779
531 3ID 0.8778
532 DIN 0.8778
533 M6N 0.8778
534 OSE 0.8777
535 XQ0 0.8775
536 PEA 0.8774
537 M6H 0.8774
538 Q24 0.8774
539 P9E 0.8773
540 4TB 0.8772
541 VNJ 0.8771
542 F4E 0.8770
543 3C4 0.8770
544 M5K 0.8769
545 MPV 0.8765
546 5WY 0.8763
547 6AI 0.8763
548 TPA 0.8763
549 8H8 0.8763
550 J6W 0.8761
551 TCA 0.8760
552 MEW 0.8759
553 3U4 0.8759
554 IOP 0.8759
555 NID 0.8757
556 3HB 0.8756
557 0W8 0.8756
558 KTW 0.8756
559 CWS 0.8756
560 FDR 0.8756
561 1A7 0.8755
562 DXG 0.8755
563 LPK 0.8754
564 826 0.8754
565 HBD 0.8754
566 PPR 0.8752
567 4AA 0.8752
568 12T 0.8751
569 36Y 0.8751
570 2KA 0.8750
571 MTL 0.8750
572 4RU 0.8750
573 5GU 0.8750
574 QPR 0.8749
575 2F6 0.8749
576 GAB 0.8749
577 CLW 0.8747
578 BTM 0.8746
579 6RQ 0.8746
580 15E 0.8746
581 TZF 0.8744
582 QBK 0.8744
583 3R4 0.8744
584 SVD 0.8744
585 7QS 0.8744
586 2LP 0.8742
587 4FA 0.8742
588 CXF 0.8742
589 8TX 0.8742
590 SKA 0.8742
591 36R 0.8741
592 5MK 0.8741
593 A7W 0.8741
594 HNK 0.8740
595 ZYR 0.8740
596 PNZ 0.8740
597 ANN 0.8739
598 6CS 0.8739
599 HMH 0.8738
600 ARP 0.8738
601 PBN 0.8736
602 LZM 0.8734
603 ES6 0.8734
604 1HN 0.8733
605 RHU 0.8733
606 UNJ 0.8732
607 INE 0.8732
608 G3P 0.8732
609 AX3 0.8731
610 27B 0.8730
611 4LW 0.8730
612 F12 0.8730
613 KUF 0.8730
614 PCS 0.8729
615 GJP 0.8727
616 ASC 0.8727
617 DHS 0.8727
618 2FT 0.8727
619 ASP 0.8726
620 TH7 0.8726
621 JG8 0.8724
622 KPA 0.8724
623 AJV 0.8724
624 1LQ 0.8724
625 9R5 0.8723
626 2CK 0.8722
627 TAG 0.8722
628 XHP 0.8721
629 M5H 0.8721
630 TZM 0.8720
631 7Q1 0.8720
632 DHR 0.8720
633 AEF 0.8720
634 0A9 0.8720
635 IP8 0.8719
636 174 0.8719
637 5NE 0.8718
638 42C 0.8718
639 2AL 0.8718
640 MQB 0.8716
641 11S 0.8716
642 7VP 0.8716
643 E5X 0.8715
644 36M 0.8713
645 ENO 0.8713
646 NYL 0.8710
647 FYU 0.8709
648 FIX 0.8709
649 270 0.8708
650 GLR 0.8708
651 Y4L 0.8706
652 AL0 0.8705
653 4V2 0.8705
654 ONR 0.8703
655 44W 0.8701
656 PC 0.8701
657 6VD 0.8699
658 M58 0.8699
659 DMD 0.8698
660 AN3 0.8698
661 DBJ 0.8697
662 OVV 0.8696
663 3Z8 0.8696
664 AHC 0.8695
665 53C 0.8695
666 OW4 0.8694
667 MRW 0.8691
668 AKH 0.8691
669 PBC 0.8691
670 3NT 0.8691
671 PTU 0.8690
672 YRL 0.8689
673 NPY 0.8689
674 TOF 0.8688
675 TPO 0.8688
676 8GK 0.8688
677 E35 0.8687
678 OAA 0.8687
679 6ME 0.8687
680 2MI 0.8686
681 VGD 0.8685
682 0RW 0.8683
683 0FN 0.8683
684 OTW 0.8682
685 BEZ 0.8682
686 GDE 0.8681
687 8WT 0.8681
688 BSX 0.8681
689 PXL 0.8680
690 HHT 0.8680
691 MJ2 0.8680
692 NHG 0.8679
693 DEE 0.8679
694 DYA 0.8679
695 SX1 0.8678
696 DHC 0.8678
697 FP1 0.8678
698 RLG 0.8673
699 ZXD 0.8673
700 ES9 0.8673
701 2FQ 0.8673
702 2EC 0.8673
703 M6Z 0.8672
704 L22 0.8672
705 DBH 0.8671
706 NOJ 0.8671
707 KTJ 0.8671
708 TAR 0.8671
709 PH3 0.8670
710 1SQ 0.8669
711 TLA 0.8669
712 261 0.8669
713 KFH 0.8669
714 PRF 0.8669
715 KGK 0.8668
716 9DG 0.8668
717 GO2 0.8668
718 FK1 0.8667
719 3HG 0.8666
720 NCA 0.8665
721 4BZ 0.8665
722 N3W 0.8664
723 C5A 0.8662
724 XAZ 0.8661
725 AMH 0.8661
726 2BX 0.8661
727 SME 0.8660
728 RB5 0.8659
729 BEN 0.8659
730 PRZ 0.8659
731 HKD 0.8657
732 SVN 0.8657
733 XX3 0.8657
734 1BN 0.8656
735 MO8 0.8656
736 IFL 0.8655
737 KMY 0.8655
738 5VM 0.8654
739 FUD 0.8654
740 G5V 0.8653
741 IP0 0.8653
742 SWA 0.8652
743 44V 0.8651
744 LDP 0.8650
745 HXX 0.8650
746 AT3 0.8649
747 HMU 0.8648
748 3AB 0.8648
749 OW7 0.8648
750 0W1 0.8646
751 1AL 0.8645
752 BAM 0.8645
753 NIO 0.8645
754 QUZ 0.8644
755 9UL 0.8644
756 EHM 0.8642
757 BTY 0.8641
758 9SE 0.8641
759 X1S 0.8641
760 1Z6 0.8640
761 1DV 0.8639
762 N1E 0.8638
763 4JC 0.8638
764 KYA 0.8637
765 41K 0.8637
766 GZL 0.8636
767 SYG 0.8635
768 1P7 0.8634
769 H4N 0.8633
770 REL 0.8632
771 SQ7 0.8632
772 TVP 0.8631
773 7ME 0.8630
774 ROI 0.8630
775 0FO 0.8630
776 CFA 0.8626
777 GGB 0.8625
778 L7T 0.8625
779 XRG 0.8624
780 ZON 0.8623
781 9BF 0.8621
782 3S5 0.8620
783 MVN 0.8620
784 HLZ 0.8620
785 TEO 0.8618
786 39O 0.8617
787 PZA 0.8614
788 XYH 0.8613
789 75K 0.8613
790 RP5 0.8611
791 2AK 0.8611
792 GZ2 0.8611
793 VXX 0.8611
794 9MG 0.8610
795 PRA 0.8609
796 URP 0.8609
797 DXP 0.8609
798 YIE 0.8607
799 UNU 0.8607
800 5LA 0.8607
801 4ME 0.8606
802 JZ7 0.8606
803 7WV 0.8603
804 LAO 0.8603
805 8K2 0.8602
806 SQ4 0.8601
807 AC0 0.8600
808 BPY 0.8600
809 EGR 0.8600
810 6HO 0.8599
811 VK3 0.8598
812 7WG 0.8597
813 3HA 0.8597
814 GUN 0.8597
815 5B1 0.8593
816 SW7 0.8593
817 RJY 0.8590
818 JXZ 0.8589
819 CXH 0.8588
820 BVA 0.8586
821 428 0.8586
822 3ZB 0.8585
823 PEQ 0.8582
824 0V5 0.8582
825 UN1 0.8580
826 R9Y 0.8580
827 24W 0.8578
828 24B 0.8576
829 DX3 0.8576
830 Q08 0.8576
831 SQV 0.8575
832 X0U 0.8574
833 LQ2 0.8573
834 RBL 0.8572
835 FRU 0.8572
836 GJS 0.8570
837 BPN 0.8570
838 XIZ 0.8569
839 4NZ 0.8567
840 OVP 0.8564
841 O2A 0.8562
842 3R6 0.8560
843 NTN 0.8559
844 LYS 0.8557
845 4XS 0.8555
846 HL4 0.8554
847 1GP 0.8552
848 KBZ 0.8552
849 39U 0.8548
850 XUL 0.8542
851 30G 0.8539
852 4I8 0.8539
853 4BY 0.8539
854 28N 0.8538
855 RQD 0.8532
856 GP9 0.8523
857 KW8 0.8522
858 3F0 0.8518
859 3BZ 0.8518
860 WCE 0.8516
861 8W9 0.8514
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4IKR; Ligand: PVP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 4ikr.bio1) has 31 residues
No: Leader PDB Ligand Sequence Similarity
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