Receptor
PDB id Resolution Class Description Source Keywords
4agl 1.7 Å NON-ENZYME: BINDING STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO THE S SMALL MOLECULE PHIKAN784 HOMO SAPIENS TRANSCRIPTION CELL CYCLE APOPTOSIS CANCER MUTATION SURFACREVICE PROTEIN FOLDING AGGREGATION MUTANT RESCUE SMALLDRUG PROTEIN STABILIZATION HALOGEN BONDING
Ref.: HALOGEN-ENRICHED FRAGMENT LIBRARIES AS LEADS FOR DR OF MUTANT P53. J.AM.CHEM.SOC. V. 134 6810 2012
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
P84 A:400;
B:400;
 Valid;
Valid;
 none;
none;
 Kd = 225 uM
486.13 C14 H20 I2 N2 O CN1CC...
ZN A:1300;
B:1300;
 Part of Protein;
Part of Protein;
 none;
none;
 submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6SI3 1.4 Å NON-ENZYME: BINDING P53 CANCER MUTANT Y220S IN COMPLEX WITH SMALL-MOLECULE STABI PK9301 HOMO SAPIENS P53 TRANSCRIPTION FACTOR TUMOR SUPPRESSOR CANCER THERAPYONCOGENIC MUTANT PROTEIN MISFOLDING DNA-BINDING DOMAIN DSURFACE CREVICE SMALL-MOLECULE STABILIZER MUTANT P53 RESCBINDING PROTEIN
Ref.: TARGETING CAVITY-CREATING P53 CANCER MUTATIONS WITH SMALL-MOLECULE STABILIZERS: THE Y220X PARADIGM. ACS CHEM.BIOL. V. 15 657 2020
Members (40)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 552 families.
1 2X0W - X0W C10 H11 N O2 S Cc1nc2cc(c....
2 4AGM Kd = 105 uM P86 C16 H24 I2 N2 O CCN(CC)C1C....
3 5AB9 Kd = 470 uM 92O C15 H20 N2 CCc1cccc2c....
4 6GGE - EYE C21 H23 N2 S CCn1c2ccc(....
5 2X0V - X0V C7 H7 F3 N2 c1cc(c(cc1....
6 5O1A Kd = 30 uM 9H5 C16 H17 I2 N3 O2 CN1CCN(CC1....
7 5G4O Kd = 37.2 uM O80 C17 H17 F3 N2 CN(C)Cc1cc....
8 5O1F Kd = 30 uM 9GQ C15 H16 I N O4 CCCCOc1cc(....
9 5AOJ Kd = 21 uM Y0V C11 H7 I2 N O3 c1ccn(c1)c....
10 6GGF - EXQ C21 H23 N2 S CCn1c2ccc(....
11 5O1G Kd = 116 uM 9GK C19 H16 I N O4 c1ccc(cc1)....
12 5O1I Kd = 4 uM 9GH C16 H16 I N3 O3 S CCN(CC)c1n....
13 5AOL Kd = 4800 uM UFV C7 H6 Br F3 N2 c1c(cc(c(c....
14 6GGC - EXN C20 H21 N2 O CCn1c2ccc(....
15 5AOI Kd = 940 uM RZH C13 H17 Br N2 CCc1cc(cc2....
16 5O1D Kd = 22 uM 9GW C14 H14 I N O4 CCCOc1cc(c....
17 4AGP Kd = 20.6 uM P51 C25 H31 I N2 O2 CCN(CC)C1C....
18 6SI4 Kd = 5.9 uM LEK C19 H19 N3 S CCn1c2ccc(....
19 3ZME - QC5 C17 H19 F N4 CN(C)CCn1c....
20 5AOK - GOH C11 H10 N6 O c1ccn(c1)c....
21 6SI3 Kd = 4 uM LEB C16 H14 Br F3 N2 CNCc1ccc2c....
22 5A7B Kd = 271 uM KMN C27 H32 N2 O2 CCN(CC)C1C....
23 5ABA Kd = 1040 uM UL7 C17 H24 Br Cl N2 O2 c1c(cc(c(c....
24 6GGD - EYB C19 H20 N3 O CCn1c2ccc(....
25 2VUK Kd = 125 uM P83 C16 H18 N2 CCn1c2cccc....
26 4AGQ Kd = 9.7 uM P96 C25 H32 I N3 O CCN(CC)C1C....
27 5O1E Kd = 33 uM 9GT C14 H12 I N O4 C=CCOc1cc(....
28 4AGN Kd = 107 uM NXG C19 H27 I N2 O2 CCN(CC)C1C....
29 6GGA - EY2 C16 H18 Br N2 CCn1c2ccc(....
30 5O1B Kd = 20 uM 9H2 C11 H9 I2 N O2 c1ccn(c1)c....
31 5AOM Kd = 1270 uM FY8 C12 H15 Cl N2 O2 c1cc(c(cc1....
32 2X0U - X0U C9 H8 N2 O2 S c1c2c(cc3c....
33 4AGO Kd = 15.5 uM P74 C24 H36 I N3 O3 CCN(CC)C1C....
34 5O1C Kd = 113 uM 9GZ C17 H11 F I N O3 c1ccn(c1)c....
35 5G4N Kd = 101 uM O83 C16 H16 F2 N2 CNCc1ccc2c....
36 6GGB - EXQ C21 H23 N2 S CCn1c2ccc(....
37 5O1H Kd = 14 uM 9GN C14 H14 I N O3 S CCCSc1cc(c....
38 4AGL Kd = 225 uM P84 C14 H20 I2 N2 O CN1CCC(CC1....
39 6SI0 Kd = 5.3 uM LEK C19 H19 N3 S CCn1c2ccc(....
40 5G4M Kd = 138 uM O82 C16 H17 F N2 CNCc1ccc2c....
70% Homology Family (40)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 426 families.
1 2X0W - X0W C10 H11 N O2 S Cc1nc2cc(c....
2 4AGM Kd = 105 uM P86 C16 H24 I2 N2 O CCN(CC)C1C....
3 5AB9 Kd = 470 uM 92O C15 H20 N2 CCc1cccc2c....
4 6GGE - EYE C21 H23 N2 S CCn1c2ccc(....
5 2X0V - X0V C7 H7 F3 N2 c1cc(c(cc1....
6 5O1A Kd = 30 uM 9H5 C16 H17 I2 N3 O2 CN1CCN(CC1....
7 5G4O Kd = 37.2 uM O80 C17 H17 F3 N2 CN(C)Cc1cc....
8 5O1F Kd = 30 uM 9GQ C15 H16 I N O4 CCCCOc1cc(....
9 5AOJ Kd = 21 uM Y0V C11 H7 I2 N O3 c1ccn(c1)c....
10 6GGF - EXQ C21 H23 N2 S CCn1c2ccc(....
11 5O1G Kd = 116 uM 9GK C19 H16 I N O4 c1ccc(cc1)....
12 5O1I Kd = 4 uM 9GH C16 H16 I N3 O3 S CCN(CC)c1n....
13 5AOL Kd = 4800 uM UFV C7 H6 Br F3 N2 c1c(cc(c(c....
14 6GGC - EXN C20 H21 N2 O CCn1c2ccc(....
15 5AOI Kd = 940 uM RZH C13 H17 Br N2 CCc1cc(cc2....
16 5O1D Kd = 22 uM 9GW C14 H14 I N O4 CCCOc1cc(c....
17 4AGP Kd = 20.6 uM P51 C25 H31 I N2 O2 CCN(CC)C1C....
18 6SI4 Kd = 5.9 uM LEK C19 H19 N3 S CCn1c2ccc(....
19 3ZME - QC5 C17 H19 F N4 CN(C)CCn1c....
20 5AOK - GOH C11 H10 N6 O c1ccn(c1)c....
21 6SI3 Kd = 4 uM LEB C16 H14 Br F3 N2 CNCc1ccc2c....
22 5A7B Kd = 271 uM KMN C27 H32 N2 O2 CCN(CC)C1C....
23 5ABA Kd = 1040 uM UL7 C17 H24 Br Cl N2 O2 c1c(cc(c(c....
24 6GGD - EYB C19 H20 N3 O CCn1c2ccc(....
25 2VUK Kd = 125 uM P83 C16 H18 N2 CCn1c2cccc....
26 4AGQ Kd = 9.7 uM P96 C25 H32 I N3 O CCN(CC)C1C....
27 5O1E Kd = 33 uM 9GT C14 H12 I N O4 C=CCOc1cc(....
28 4AGN Kd = 107 uM NXG C19 H27 I N2 O2 CCN(CC)C1C....
29 6GGA - EY2 C16 H18 Br N2 CCn1c2ccc(....
30 5O1B Kd = 20 uM 9H2 C11 H9 I2 N O2 c1ccn(c1)c....
31 5AOM Kd = 1270 uM FY8 C12 H15 Cl N2 O2 c1cc(c(cc1....
32 2X0U - X0U C9 H8 N2 O2 S c1c2c(cc3c....
33 4AGO Kd = 15.5 uM P74 C24 H36 I N3 O3 CCN(CC)C1C....
34 5O1C Kd = 113 uM 9GZ C17 H11 F I N O3 c1ccn(c1)c....
35 5G4N Kd = 101 uM O83 C16 H16 F2 N2 CNCc1ccc2c....
36 6GGB - EXQ C21 H23 N2 S CCn1c2ccc(....
37 5O1H Kd = 14 uM 9GN C14 H14 I N O3 S CCCSc1cc(c....
38 4AGL Kd = 225 uM P84 C14 H20 I2 N2 O CN1CCC(CC1....
39 6SI0 Kd = 5.3 uM LEK C19 H19 N3 S CCn1c2ccc(....
40 5G4M Kd = 138 uM O82 C16 H17 F N2 CNCc1ccc2c....
50% Homology Family (40)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 322 families.
1 2X0W - X0W C10 H11 N O2 S Cc1nc2cc(c....
2 4AGM Kd = 105 uM P86 C16 H24 I2 N2 O CCN(CC)C1C....
3 5AB9 Kd = 470 uM 92O C15 H20 N2 CCc1cccc2c....
4 6GGE - EYE C21 H23 N2 S CCn1c2ccc(....
5 2X0V - X0V C7 H7 F3 N2 c1cc(c(cc1....
6 5O1A Kd = 30 uM 9H5 C16 H17 I2 N3 O2 CN1CCN(CC1....
7 5G4O Kd = 37.2 uM O80 C17 H17 F3 N2 CN(C)Cc1cc....
8 5O1F Kd = 30 uM 9GQ C15 H16 I N O4 CCCCOc1cc(....
9 5AOJ Kd = 21 uM Y0V C11 H7 I2 N O3 c1ccn(c1)c....
10 6GGF - EXQ C21 H23 N2 S CCn1c2ccc(....
11 5O1G Kd = 116 uM 9GK C19 H16 I N O4 c1ccc(cc1)....
12 5O1I Kd = 4 uM 9GH C16 H16 I N3 O3 S CCN(CC)c1n....
13 5AOL Kd = 4800 uM UFV C7 H6 Br F3 N2 c1c(cc(c(c....
14 6GGC - EXN C20 H21 N2 O CCn1c2ccc(....
15 5AOI Kd = 940 uM RZH C13 H17 Br N2 CCc1cc(cc2....
16 5O1D Kd = 22 uM 9GW C14 H14 I N O4 CCCOc1cc(c....
17 4AGP Kd = 20.6 uM P51 C25 H31 I N2 O2 CCN(CC)C1C....
18 6SI4 Kd = 5.9 uM LEK C19 H19 N3 S CCn1c2ccc(....
19 3ZME - QC5 C17 H19 F N4 CN(C)CCn1c....
20 5AOK - GOH C11 H10 N6 O c1ccn(c1)c....
21 6SI3 Kd = 4 uM LEB C16 H14 Br F3 N2 CNCc1ccc2c....
22 5A7B Kd = 271 uM KMN C27 H32 N2 O2 CCN(CC)C1C....
23 5ABA Kd = 1040 uM UL7 C17 H24 Br Cl N2 O2 c1c(cc(c(c....
24 6GGD - EYB C19 H20 N3 O CCn1c2ccc(....
25 2VUK Kd = 125 uM P83 C16 H18 N2 CCn1c2cccc....
26 4AGQ Kd = 9.7 uM P96 C25 H32 I N3 O CCN(CC)C1C....
27 5O1E Kd = 33 uM 9GT C14 H12 I N O4 C=CCOc1cc(....
28 4AGN Kd = 107 uM NXG C19 H27 I N2 O2 CCN(CC)C1C....
29 6GGA - EY2 C16 H18 Br N2 CCn1c2ccc(....
30 5O1B Kd = 20 uM 9H2 C11 H9 I2 N O2 c1ccn(c1)c....
31 5AOM Kd = 1270 uM FY8 C12 H15 Cl N2 O2 c1cc(c(cc1....
32 2X0U - X0U C9 H8 N2 O2 S c1c2c(cc3c....
33 4AGO Kd = 15.5 uM P74 C24 H36 I N3 O3 CCN(CC)C1C....
34 5O1C Kd = 113 uM 9GZ C17 H11 F I N O3 c1ccn(c1)c....
35 5G4N Kd = 101 uM O83 C16 H16 F2 N2 CNCc1ccc2c....
36 6GGB - EXQ C21 H23 N2 S CCn1c2ccc(....
37 5O1H Kd = 14 uM 9GN C14 H14 I N O3 S CCCSc1cc(c....
38 4AGL Kd = 225 uM P84 C14 H20 I2 N2 O CN1CCC(CC1....
39 6SI0 Kd = 5.3 uM LEK C19 H19 N3 S CCn1c2ccc(....
40 5G4M Kd = 138 uM O82 C16 H17 F N2 CNCc1ccc2c....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: P84; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 P84 1 1
2 P86 0.426471 0.942308
Similar Ligands (3D)
Ligand no: 1; Ligand: P84; Similar ligands found: 403
No: Ligand Similarity coefficient
1 9KH 0.9478
2 OMD 0.9474
3 HQ9 0.9323
4 57O 0.9243
5 R9S 0.9228
6 NBG 0.9207
7 AS3 0.9200
8 LYL 0.9187
9 AX3 0.9175
10 DIU 0.9161
11 XQI 0.9132
12 OHP 0.9129
13 CFA 0.9117
14 BDP 0.9107
15 URC 0.9102
16 HPT 0.9097
17 4XS 0.9077
18 ASC 0.9077
19 3C4 0.9076
20 K5W 0.9071
21 SAF 0.9050
22 HHT 0.9045
23 MJ2 0.9041
24 B2J 0.9036
25 4XV 0.9031
26 CN0 0.9029
27 EV0 0.9024
28 EVA 0.9022
29 AEH 0.9014
30 C2U 0.9010
31 UFV 0.9010
32 PRZ 0.9007
33 YO5 0.8999
34 IJZ 0.8997
35 4MU 0.8996
36 JTH 0.8992
37 OA3 0.8990
38 DOR 0.8989
39 SRO 0.8983
40 B4O 0.8981
41 GCU 0.8976
42 KJU 0.8974
43 2CL 0.8974
44 8TX 0.8972
45 6OT 0.8961
46 BGC 0.8956
47 OKM 0.8950
48 FOT 0.8950
49 BSX 0.8948
50 A13 0.8948
51 JZ4 0.8947
52 KBB 0.8946
53 NAG 0.8942
54 AY4 0.8939
55 2LP 0.8939
56 GCB 0.8934
57 KIB 0.8933
58 0LH 0.8933
59 7ME 0.8930
60 92K 0.8925
61 KIA 0.8922
62 QSH 0.8918
63 1P8 0.8918
64 GLC 0.8918
65 NCD 0.8917
66 TNX 0.8914
67 KFH 0.8911
68 FBU 0.8909
69 KTA 0.8907
70 5GU 0.8907
71 SYA 0.8906
72 23J 0.8906
73 II6 0.8904
74 IPT 0.8903
75 GAL 0.8903
76 1LN 0.8899
77 H7Y 0.8896
78 K3Q 0.8893
79 2AL 0.8893
80 3MG 0.8892
81 MO8 0.8890
82 0W1 0.8890
83 JFJ 0.8889
84 E35 0.8888
85 LGC 0.8883
86 DHY 0.8883
87 6ME 0.8882
88 ORO 0.8881
89 EOL 0.8880
90 5JL 0.8880
91 6FZ 0.8867
92 KBG 0.8864
93 PRY 0.8864
94 FBV 0.8862
95 XAZ 0.8862
96 NVU 0.8859
97 FRU 0.8858
98 SBK 0.8854
99 DQA 0.8853
100 0F9 0.8853
101 ZZZ 0.8851
102 4ME 0.8850
103 X0W 0.8849
104 IAC 0.8848
105 Q88 0.8848
106 CKU 0.8847
107 8NX 0.8847
108 TAG 0.8841
109 5JQ 0.8840
110 NOJ 0.8840
111 TSR 0.8836
112 AIN 0.8835
113 6LW 0.8834
114 PAC 0.8832
115 VOH 0.8831
116 ISD 0.8831
117 V55 0.8831
118 DA4 0.8829
119 EUG 0.8829
120 B55 0.8828
121 G2F 0.8828
122 TWO 0.8826
123 FA3 0.8824
124 FP1 0.8824
125 M1Z 0.8822
126 1X7 0.8821
127 75K 0.8820
128 GLO 0.8819
129 2LT 0.8818
130 QY9 0.8818
131 SVD 0.8818
132 BMA 0.8817
133 BNT 0.8816
134 ASO 0.8814
135 GCS 0.8813
136 42J 0.8812
137 ONR 0.8808
138 IPD 0.8807
139 34D 0.8807
140 S24 0.8805
141 NOY 0.8805
142 EPR 0.8803
143 SJ5 0.8802
144 SYV 0.8800
145 6CS 0.8799
146 3HP 0.8799
147 54G 0.8798
148 DFB 0.8797
149 A29 0.8795
150 KDF 0.8794
151 G3F 0.8792
152 8S0 0.8792
153 7MU 0.8791
154 MQB 0.8791
155 A7W 0.8790
156 GTQ 0.8790
157 293 0.8789
158 R9Y 0.8788
159 67X 0.8787
160 NGT 0.8785
161 5MK 0.8783
162 TFU 0.8783
163 LDP 0.8780
164 8WO 0.8779
165 GDE 0.8779
166 ZZ2 0.8777
167 MAN 0.8777
168 HJP 0.8776
169 YTX 0.8775
170 3AL 0.8774
171 NLA 0.8774
172 EYK 0.8773
173 GRX 0.8771
174 7WR 0.8771
175 8IG 0.8770
176 IFM 0.8770
177 LNR 0.8769
178 SX1 0.8769
179 HQJ 0.8766
180 61M 0.8765
181 069 0.8765
182 SHA 0.8763
183 TSS 0.8763
184 DBH 0.8760
185 B40 0.8760
186 4AA 0.8759
187 LCN 0.8752
188 9PY 0.8751
189 KFN 0.8750
190 KDG 0.8749
191 8U3 0.8748
192 HA5 0.8748
193 4NC 0.8746
194 MS9 0.8745
195 CSN 0.8743
196 7N0 0.8742
197 D1X 0.8740
198 DX3 0.8738
199 J6W 0.8737
200 790 0.8735
201 EMZ 0.8734
202 ZWZ 0.8733
203 4JT 0.8732
204 ZZ3 0.8730
205 DIN 0.8730
206 3DM 0.8730
207 DHK 0.8729
208 SOE 0.8727
209 ICO 0.8726
210 M3Q 0.8726
211 IFL 0.8726
212 NGO 0.8724
213 5M0 0.8724
214 3HA 0.8724
215 KG1 0.8723
216 3IT 0.8722
217 JP2 0.8721
218 8GK 0.8720
219 AJ2 0.8720
220 ES2 0.8720
221 BTY 0.8720
222 DRL 0.8720
223 3R6 0.8720
224 2FG 0.8718
225 DHS 0.8717
226 GJZ 0.8715
227 AHR 0.8713
228 G1P 0.8712
229 F0J 0.8711
230 VGD 0.8710
231 M5K 0.8710
232 5RG 0.8709
233 2A7 0.8709
234 AZF 0.8708
235 263 0.8708
236 J9Q 0.8706
237 ESI 0.8706
238 N2Z 0.8705
239 RM1 0.8704
240 IBM 0.8704
241 4FH 0.8702
242 4HM 0.8702
243 6VD 0.8701
244 6XI 0.8701
245 MRW 0.8700
246 AW5 0.8699
247 9TZ 0.8699
248 CWM 0.8699
249 1F1 0.8697
250 QM1 0.8697
251 2XX 0.8695
252 IOS 0.8693
253 S3C 0.8693
254 JA8 0.8693
255 KYA 0.8691
256 3OC 0.8691
257 URS 0.8690
258 FE DB1 0.8690
259 L5V 0.8690
260 FA1 0.8690
261 3F0 0.8689
262 MBG 0.8688
263 FGZ 0.8686
264 NDG 0.8683
265 GT0 0.8683
266 5NI 0.8682
267 SHG 0.8681
268 LIP 0.8681
269 IFP 0.8681
270 SYC 0.8681
271 45L 0.8680
272 3M0 0.8679
273 QPR 0.8679
274 R20 0.8678
275 2O6 0.8678
276 OXC 0.8677
277 261 0.8676
278 92P 0.8675
279 PFB 0.8673
280 51R 0.8673
281 EXD 0.8672
282 CWJ 0.8670
283 K7M 0.8666
284 PZI 0.8666
285 GOX 0.8665
286 PA1 0.8664
287 DBX 0.8664
288 S76 0.8664
289 ES0 0.8664
290 5CU 0.8663
291 HXX 0.8663
292 BCU 0.8663
293 XCZ 0.8662
294 463 0.8661
295 DIE 0.8660
296 5OF 0.8657
297 4CS 0.8657
298 OXZ 0.8656
299 FBW 0.8654
300 8XQ 0.8653
301 ZON 0.8652
302 MZM 0.8652
303 BNF 0.8650
304 XIY 0.8647
305 3NY 0.8645
306 N3W 0.8642
307 QUS 0.8641
308 4HC 0.8640
309 AQO 0.8640
310 L7T 0.8637
311 FLC 0.8635
312 97T 0.8635
313 TXW 0.8635
314 4SX 0.8634
315 ICT 0.8632
316 GTR 0.8632
317 GL1 0.8631
318 XM0 0.8631
319 REL 0.8630
320 GZQ 0.8626
321 VXX 0.8624
322 BPY 0.8623
323 L21 0.8622
324 5OB 0.8622
325 ICB 0.8621
326 IV2 0.8620
327 15N 0.8614
328 6NI 0.8612
329 E7S 0.8612
330 GDL 0.8611
331 N2I 0.8611
332 HPS 0.8610
333 MEW 0.8610
334 KOJ 0.8609
335 GLU 0.8609
336 2H5 0.8607
337 BK9 0.8607
338 CBF 0.8606
339 LAO 0.8606
340 SMN 0.8604
341 YIO 0.8604
342 94W 0.8602
343 SG2 0.8601
344 36R 0.8600
345 4ZC 0.8600
346 JR2 0.8600
347 2F6 0.8600
348 2AK 0.8599
349 CTL 0.8598
350 5XC 0.8597
351 717 0.8597
352 SWA 0.8596
353 5WU 0.8595
354 AFR 0.8594
355 7ZC 0.8593
356 9F8 0.8592
357 KGK 0.8591
358 GFP 0.8589
359 X0V 0.8586
360 UNC 0.8584
361 R1P 0.8581
362 QMP 0.8581
363 8OZ 0.8579
364 E7Z 0.8576
365 8W9 0.8574
366 HBO 0.8572
367 5RO 0.8572
368 FK8 0.8571
369 GC2 0.8569
370 3DO 0.8568
371 5VM 0.8568
372 GLA 0.8567
373 BZ3 0.8567
374 GLF 0.8566
375 Z5P 0.8565
376 149 0.8565
377 DEE 0.8565
378 QIC 0.8562
379 DHB 0.8560
380 EKZ 0.8560
381 2D0 0.8560
382 C2A 0.8560
383 PHU 0.8560
384 HQD 0.8560
385 G5V 0.8557
386 A2G 0.8556
387 CLW 0.8555
388 2EC 0.8554
389 ET2 0.8552
390 APS 0.8552
391 9BF 0.8552
392 ES5 0.8550
393 Q24 0.8550
394 F9Y 0.8550
395 948 0.8547
396 6RQ 0.8540
397 BCP 0.8535
398 DMJ 0.8532
399 OCH 0.8530
400 42C 0.8525
401 SNG 0.8521
402 ABV 0.8520
403 PJL 0.8515
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6SI3; Ligand: LEB; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 6si3.bio2) has 21 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 6SI3; Ligand: LEB; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 6si3.bio1) has 24 residues
No: Leader PDB Ligand Sequence Similarity
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