Receptor
PDB id Resolution Class Description Source Keywords
4YLL 1.4 Å EC: 2.7.12.1 CRYSTAL STRUCTURE OF DYRK1AA IN COMPLEX WITH 10-BROMO-SUBSTI INDOLO[3,2-C]QUINOLONE-6-CARBOXYLIC ACID INHIBITOR 5T HOMO SAPIENS HALOGEN INHIBITOR STRUCTURAL GENOMICS STRUCTURAL GENOMICSCONSORTIUM SGC TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: 10-IODO-11H-INDOLO[3,2-C]QUINOLINE-6-CARBOXYLIC ACI SELECTIVE INHIBITORS OF DYRK1A. J.MED.CHEM. V. 58 3131 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SO4 A:503;
A:505;
A:501;
A:502;
A:504;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
EDO A:513;
A:510;
A:509;
A:507;
A:514;
A:511;
A:506;
A:508;
A:512;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
4E3 A:515;
Valid;
none;
ic50 = 0.12 uM
467.055 C16 H8 Br I N2 O2 c1cc2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4YLL 1.4 Å EC: 2.7.12.1 CRYSTAL STRUCTURE OF DYRK1AA IN COMPLEX WITH 10-BROMO-SUBSTI INDOLO[3,2-C]QUINOLONE-6-CARBOXYLIC ACID INHIBITOR 5T HOMO SAPIENS HALOGEN INHIBITOR STRUCTURAL GENOMICS STRUCTURAL GENOMICSCONSORTIUM SGC TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: 10-IODO-11H-INDOLO[3,2-C]QUINOLINE-6-CARBOXYLIC ACI SELECTIVE INHIBITORS OF DYRK1A. J.MED.CHEM. V. 58 3131 2015
Members (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 5A4T ic50 = 1.3 uM AJG C10 H7 N3 O S CC(=O)N=C1....
2 5A4Q ic50 = 2.9 uM Y3L C9 H7 Cl N2 O S CC(=O)Nc1n....
3 5A3X ic50 = 0.8 uM QIV C9 H8 N2 O2 S CC(=O)Nc1n....
4 4YLK ic50 = 0.18 uM 4E2 C16 H8 Cl I N2 O2 c1cc2c3c(c....
5 4MQ1 - 2C3 C25 H22 Cl2 N6 O4 COc1ncc2c(....
6 4YLL ic50 = 0.12 uM 4E3 C16 H8 Br I N2 O2 c1cc2c3c(c....
70% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 5A4T ic50 = 1.3 uM AJG C10 H7 N3 O S CC(=O)N=C1....
2 5A4Q ic50 = 2.9 uM Y3L C9 H7 Cl N2 O S CC(=O)Nc1n....
3 5A3X ic50 = 0.8 uM QIV C9 H8 N2 O2 S CC(=O)Nc1n....
4 4YLK ic50 = 0.18 uM 4E2 C16 H8 Cl I N2 O2 c1cc2c3c(c....
5 4MQ1 - 2C3 C25 H22 Cl2 N6 O4 COc1ncc2c(....
6 4YLL ic50 = 0.12 uM 4E3 C16 H8 Br I N2 O2 c1cc2c3c(c....
50% Homology Family (9)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 5A4T ic50 = 1.3 uM AJG C10 H7 N3 O S CC(=O)N=C1....
2 5A4Q ic50 = 2.9 uM Y3L C9 H7 Cl N2 O S CC(=O)Nc1n....
3 5A3X ic50 = 0.8 uM QIV C9 H8 N2 O2 S CC(=O)Nc1n....
4 4YLK ic50 = 0.18 uM 4E2 C16 H8 Cl I N2 O2 c1cc2c3c(c....
5 4MQ1 - 2C3 C25 H22 Cl2 N6 O4 COc1ncc2c(....
6 4YLL ic50 = 0.12 uM 4E3 C16 H8 Br I N2 O2 c1cc2c3c(c....
7 4IFC - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
8 4IIR - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
9 4IJP ic50 = 0.016 uM 1EH C20 H14 Cl N3 O2 S2 c1cc(c2cc(....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 4E3; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 4E3 1 1
2 4E2 0.705882 0.942857
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4YLL; Ligand: 4E3; Similar sites found: 381
This union binding pocket(no: 1) in the query (biounit: 4yll.bio1) has 24 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4HNN LYS 0.03143 0.40102 1.15607
2 4Y3O OGA 0.01916 0.41266 1.38504
3 2Z77 NCA 0.02295 0.40741 1.43885
4 4FE2 ADP 0.001749 0.44926 1.56863
5 4FE2 AIR 0.00354 0.43925 1.56863
6 4XFR CIT 0.02225 0.41081 1.66205
7 5FPE 3TR 0.02304 0.40519 1.66205
8 5LUN OGA 0.02796 0.40292 1.70455
9 1W8S FBP 0.01636 0.40272 1.90114
10 2PYW ADP 0.00002756 0.50517 1.93906
11 5MRH Q9Z 0.0003965 0.49193 1.93906
12 5W2I I3P 0.0002882 0.446 1.94553
13 5W2I ADP 0.0002882 0.446 1.94553
14 5IDB BMA 0.01513 0.42187 2.11268
15 5IDB MAN 0.01513 0.42187 2.11268
16 2IF8 ADP 0.0000411 0.5492 2.21607
17 4I94 ANP 0.00001197 0.53887 2.33333
18 4O4F ATP 0.0001367 0.45412 2.41935
19 4O4F IHP 0.0001517 0.4467 2.41935
20 4CYI ATP 0.00003783 0.49929 2.49307
21 3TII ANP 0.001095 0.46422 2.49307
22 2XSB GDL 0.01073 0.41993 2.49307
23 3V4S ATP 0.002579 0.4173 2.49307
24 2OS2 OGA 0.03193 0.40129 2.49307
25 3VOT ADP 0.001447 0.45828 2.58824
26 4RDL FUC GAL NDG FUC 0.02264 0.4101 2.5974
27 1OBD ATP 0.003315 0.43598 2.61438
28 1EHI ADP 0.008398 0.40204 2.65252
29 3NZ1 3NY 0.008261 0.43169 2.68199
30 2G30 ALA ALA PHE 0.001987 0.40563 2.71318
31 3X01 AMP 0.001025 0.47989 2.77008
32 3ORQ ADP 0.001022 0.43803 2.77008
33 4C2C ALA ALA ALA 0.01206 0.41537 2.77008
34 2I4O ATP 0.01371 0.41035 2.77008
35 4OKD GLC GLC GLC 0.02295 0.40632 2.77008
36 4LH7 1X8 0.003685 0.45071 2.78638
37 1IA9 ANP 0.00004615 0.50084 2.85714
38 1I7L ATP 0.0003727 0.44237 2.91262
39 3T4L ZEA 0.007125 0.40861 2.96296
40 3WVR AMP 0.0003244 0.47871 3.04709
41 4UWH JXM 0.004999 0.42324 3.04709
42 3K5I ADP 0.005673 0.40614 3.04709
43 4GYI ADP 0.00001055 0.55531 3.3241
44 4U98 ACP 0.0002755 0.47674 3.3241
45 2QHV OC9 0.02461 0.40168 3.33333
46 2GQS ADP 0.0007133 0.45789 3.37553
47 2GQS C2R 0.002746 0.4354 3.37553
48 2AQX ATP 0.001031 0.434 3.46021
49 4RT1 C2E 0.00753 0.41113 3.57143
50 4ZS4 ATP 0.000006161 0.53904 3.58306
51 3UDZ ADP 0.000005501 0.50504 3.60111
52 4ZGP ADP 0.004166 0.42289 3.60111
53 1TZD ADP 0.0003877 0.49606 3.63636
54 3SJK LYS PRO VAL LEU ARG THR ALA 0.009377 0.43335 3.68421
55 1GT4 UNA 0.001875 0.43873 3.77358
56 5VZ0 ADP 0.0003253 0.47345 3.87812
57 1PK8 ATP 0.0001833 0.44836 3.87812
58 3AVR OGA 0.03205 0.40055 3.87812
59 3VPC ADP 0.0001459 0.46961 3.90071
60 5C1P ADP 0.0004896 0.47569 3.92157
61 3PDT ADP 0.00001945 0.53576 4
62 3CBC DBS 0.02627 0.40403 4.0404
63 3I0O ADP 0.00001512 0.55525 4.12979
64 4XMF HSM 0.003405 0.44717 4.34783
65 1CBK ROI 0.002542 0.46065 4.375
66 4OUC 5ID 0.0000009305 0.59736 4.48179
67 1W2D ADP 0.0001048 0.51411 4.5283
68 1W2D 4IP 0.001047 0.40282 4.5283
69 5HZX 2GE 0.007733 0.42259 4.54545
70 1ZTH ADP 0.000001479 0.60466 4.65116
71 1ZP9 ATP 0.00000514 0.56272 4.65116
72 4AZW ATP 0.0008932 0.44053 4.70914
73 4AZT LY2 0.006949 0.42487 4.70914
74 4CC6 L5Y 0.01973 0.40655 4.70914
75 5TDF ADP 0.006023 0.40502 4.70914
76 2ZL7 FUC GAL NGA 0.01147 0.42833 4.74576
77 4CS9 AMP 0.03404 0.41076 4.7619
78 4DFU QUE 0.003846 0.44759 4.96894
79 5C4L 4XR 0.0001106 0.48309 4.98442
80 5C4L SIS 0.0002 0.47214 4.98442
81 5I35 ANP 0.000001282 0.58313 4.98615
82 4OCV ANP 0.00007605 0.49137 4.98615
83 4R38 RBF 0.006371 0.40397 5
84 2YRX AMP 0.00485 0.44313 5.09978
85 4WW7 AMP 0.00001848 0.50724 5.36398
86 3WH2 FLC 0.01237 0.43634 5.44218
87 5DKK FMN 0.006242 0.40436 5.51724
88 3ZJX BOG 0.004433 0.4455 5.53633
89 3DNT ATP 0.002812 0.40773 5.54017
90 2BKK ADP 0.0001864 0.49572 5.68182
91 4PU5 ANP 0.003314 0.40945 5.73951
92 5CKW ANP 0.00006415 0.52453 5.81717
93 2GEK GDP 0.01092 0.41117 5.81717
94 4OYA 1VE 0.02412 0.40772 5.81717
95 2YW2 ATP 0.00751 0.40091 5.89623
96 4LRJ ANP 0.00000007796 0.6386 5.91716
97 2CFM AMP 0.02071 0.40152 6.09418
98 3RE4 TO1 0.0001317 0.50924 6.20155
99 2IO8 ADP 0.0006015 0.4347 6.37119
100 2CFI ZZZ 0.0219 0.40425 6.38298
101 3B2Q AES 0.02045 0.40405 6.6482
102 2VQD AP2 0.000219 0.46666 6.68103
103 3HAV ATP 0.001372 0.47163 6.68896
104 2XG5 EC5 0.001654 0.46399 6.88073
105 2XG5 EC2 0.001654 0.46399 6.88073
106 5MW8 ATP 0.000001876 0.54294 7.20222
107 4WOE ADP 0.0306 0.40288 7.20222
108 3Q60 ATP 0.000003887 0.56116 7.47922
109 4GLW 0XT 0.01548 0.41188 7.47922
110 3QSB 743 0.01652 0.40636 7.47922
111 5KJW 53C 0.01294 0.42644 7.49415
112 3BP1 GUN 0.003656 0.44394 7.58621
113 3AKK ADP 0.0002342 0.47002 7.69231
114 3ETH ATP 0.0008224 0.43813 7.88732
115 4PL9 ADP 0.01636 0.40272 8.19672
116 5DZT AMP 0.0152 0.41724 8.31025
117 5LXT ACP 0.001329 0.42579 8.39161
118 4R78 AMP 0.0001935 0.50757 8.41424
119 2WBV SIA 0.004282 0.45529 8.46561
120 4IX4 ADP 0.0000339 0.48221 8.57143
121 2QX0 PH2 0.006092 0.43834 8.80503
122 2Z49 AMG 0.005055 0.43052 8.86427
123 1HFE CYS 0.01909 0.41702 8.94309
124 5IQD RIO 0.0001033 0.49331 9.18033
125 5IQD GNP 0.00009599 0.49331 9.18033
126 3REU ATP 0.008479 0.40522 9.18367
127 5DYO FLU 0.004477 0.4466 9.43396
128 2ARC ARA 0.02471 0.40159 9.7561
129 2GOO NDG 0.02649 0.40168 9.80392
130 5GZ9 ANP 0.00000009387 0.5964 9.83607
131 1TQP ATP 0.00003035 0.486 9.92908
132 2VPQ ANP 0.000225 0.45749 10.2493
133 3TPV ADE 0.006747 0.40621 10.5263
134 5XLY C2E 0.008281 0.40568 10.5263
135 4CLI 5P8 0.000001004 0.58891 11.315
136 1PVC ILE SER GLU VAL 0.00672 0.46428 11.3573
137 5KO1 6UY 0.0000001693 0.62325 12.0141
138 3LQV ADE 0.03123 0.40719 12.8205
139 5T8O 76Z 0.0000003161 0.58819 12.894
140 3WG3 A2G GAL NAG FUC 0.02399 0.40224 12.9213
141 5K2M ADP 0.0003802 0.45006 13.2075
142 4Y85 499 0.0005675 0.46242 13.253
143 3TDV GDP 0.00001446 0.52884 13.7255
144 4XYM A12 0.006268 0.40761 13.913
145 4CVN ADP 0.01798 0.41292 14.1361
146 3VHE 42Q 0.000007783 0.47301 14.2061
147 3W0O ADP 0.001033 0.40203 14.3266
148 3W0O HY0 0.001033 0.40203 14.3266
149 4IDT T28 0.000001211 0.58426 14.6814
150 5M06 ADP 0.000005213 0.56244 14.8551
151 4BKJ STI 0.0008494 0.42264 15.5556
152 5HCY 60D 0.00000002701 0.47798 15.71
153 2PUL ACP 0.000003874 0.56122 15.7895
154 4O1P ANP 0.0000006245 0.53591 16.0665
155 1BHX ASP PHE GLU GLU ILE 0.01686 0.40593 16.1905
156 3C1X CKK 0.00008214 0.48008 16.3435
157 4OAV ACP 0.000003679 0.56225 17.1745
158 3LXN MI1 0.00000002812 0.63314 17.2956
159 4MN3 ACE PHE ALA TYR M3L SER NH2 0.003991 0.42781 17.8571
160 3H0L ADP 0.01596 0.40711 18.0851
161 4GJ3 0XP 0.000006157 0.47379 18.2119
162 5EOB 5QQ 0.00000006253 0.65579 18.4953
163 4A4X JUP 0.000001477 0.52107 18.638
164 4E1Z 0MX 0.0000006158 0.56282 18.9003
165 5C03 AGS 0.00007883 0.49597 19.0058
166 3VPB ADP 0.0001837 0.44903 19.6429
167 3FHR P4O 0.000003732 0.54855 20.2381
168 4WOV 3SM 0.0001005 0.50853 20.5047
169 4G17 0VN 0.000003211 0.49317 21.8182
170 4YZC STU 0.0000002944 0.60247 24.0997
171 4E93 GUI 0.0000003776 0.50669 24.0997
172 5CEO 50D 0.000002575 0.51034 25.4848
173 3VRY B43 0.00001119 0.49441 26.0388
174 4OH4 ANP 0.000001846 0.56873 26.7267
175 5LPZ ADP 0.0000001396 0.61878 26.8072
176 5TA6 79D 0.00001145 0.48493 26.8156
177 4XH0 ADP 0.000000469 0.65543 26.8698
178 1VJY 460 0.0000001357 0.51951 27.0627
179 3KMW ATP 0.0004565 0.46673 27.1318
180 3E8N VRA 0.0000003054 0.45269 27.2727
181 3E8N ATP 0.0000003054 0.45269 27.2727
182 4Y0X ADP 0.0000002783 0.62182 27.4238
183 1Y57 MPZ 0.000001182 0.55119 27.4238
184 2PZI AXX 0.00001358 0.55008 27.4238
185 2H8H H8H 0.00002882 0.51548 27.4238
186 5U6C 7YS 0.00001022 0.51803 28.254
187 2RIO ADP 0.00000002881 0.65833 28.2548
188 5VCV 1N1 0.0000008769 0.54761 28.2958
189 5NKB 8ZT 0.0000008075 0.44704 28.4314
190 3H9R TAK 0.000001207 0.61824 28.4848
191 3UIM ANP 0.000004818 0.55014 28.5276
192 4FL3 ANP 0.00000001985 0.6317 28.5319
193 2V7O DRN 0.00000002773 0.70049 28.5714
194 1U5R ATP 0.00000004998 0.63868 28.7356
195 4DC2 ADE 0.0000003363 0.45937 28.8089
196 4P5Z Q7M 0.000002045 0.45592 28.8089
197 1OPK P16 0.000211 0.41948 28.8089
198 4EUU BX7 0.000005623 0.50096 28.8401
199 3NW7 LGV 0.0000007275 0.59805 28.9902
200 4Y8D 49J 0.0000002842 0.605 29.1176
201 5JFS 6K0 0.000001949 0.44397 29.2208
202 2WEL K88 0.0000001086 0.49485 29.3578
203 4L9I 8PR 0.000000001573 0.71594 29.3629
204 3V8S 0HD 0.00000001749 0.66821 29.3629
205 2YAB AMP 0.00000004568 0.63208 29.3629
206 4BTK DTQ 0.000002948 0.51088 29.3769
207 5LI1 ANP 0.000000009032 0.64604 29.3785
208 4WNK 453 0.0000000007466 0.61261 29.6399
209 4Y93 746 0.00000135 0.53129 29.6399
210 5LI9 ACP 0.000000001582 0.69588 29.7143
211 5UIU 8CG 0.000000002529 0.67813 29.7214
212 1K3A ACP 0.0000009572 0.6051 29.7659
213 4U0I 0LI 0.0001782 0.42039 29.8413
214 3C0G 3AM 0.000001149 0.60131 29.9145
215 5LPB ADP 0.0000006029 0.62374 30.0676
216 5HX8 66P 0.0000008755 0.52905 30.1325
217 5IH9 6BF 0.000000006846 0.53507 30.1493
218 4N70 2HX 0.000000245 0.44297 30.1829
219 4OTH DRN 0.00000005074 0.61462 30.2053
220 3LXK MI1 0.00000006342 0.56163 30.2752
221 1U59 STU 0.0000008285 0.58426 30.3136
222 5VC5 96M 0.000003299 0.50316 30.4498
223 4ASE AV9 0.00001195 0.47782 30.4709
224 3PP0 03Q 0.000004136 0.50343 30.4734
225 2VN9 GVD 0.000000003212 0.74748 30.5648
226 2X2M X2M 0.0000006281 0.56881 30.5732
227 2OO8 RAJ 0.002053 0.42146 30.5994
228 3EKK GS2 0.0000001627 0.49291 30.6189
229 2JDR L20 0.00000001888 0.43763 30.7018
230 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.00000001888 0.43763 30.7018
231 3BU5 ATP 0.00000003804 0.64397 30.719
232 2R5T ANP 0.0000001237 0.59839 30.7479
233 2PVF ACP 0.00000009694 0.63429 30.8383
234 5HES 032 0.00003102 0.48762 30.9446
235 5DMZ ADP 0.00000007694 0.63032 31.0249
236 3PLS ANP 0.0000000421 0.65081 31.2081
237 2QLU ADE 0.000001177 0.64187 31.2102
238 3GQI ACP 0.0000006736 0.58827 31.2883
239 4U44 3D9 0.000004319 0.50774 31.3253
240 3KN5 ANP 0.0000005224 0.51246 31.3846
241 3CY2 MB9 0.0000001045 0.59448 31.5287
242 3MVH WFE 0.00000004527 0.55357 31.5789
243 3KRL KRL 0.00008449 0.47956 31.5789
244 2VZ6 FEF 0.0000001283 0.64679 31.6294
245 5DBX ANP 0.00000008523 0.65527 31.7073
246 3TXO 07U 0.00000002568 0.67011 31.728
247 5HVJ ANP 0.0000004845 0.65555 31.746
248 4K33 ACP 0.00000005289 0.6293 32
249 4BFM ANP 0.0000000001388 0.73183 32.0359
250 4NFN 2KC 0.00009363 0.49812 32.0388
251 3HZT J60 0.000001431 0.60536 32.133
252 5USZ SKE 0.00002619 0.47073 32.1799
253 2QCS ANP 0.00000006993 0.57134 32.2857
254 5JGA 6KC 0.0000002383 0.50916 32.381
255 1XJD STU 0.0000001192 0.61388 32.4638
256 1RE8 BD2 0.00000004571 0.65164 32.5714
257 3FHI ANP 0.00000008883 0.56719 32.5714
258 3IDB ANP 0.000001611 0.54565 32.5714
259 4QMN DB8 0.0000003157 0.49217 32.5806
260 5W4W 9WG 0.00000003196 0.54232 32.6284
261 4KBA 1QM 0.000004283 0.49516 32.6284
262 4X7Q 3YR 0.0000001721 0.61471 32.6923
263 4EWH T77 0.000001537 0.51559 32.7273
264 3TKI S25 0.0000003919 0.42436 32.8173
265 4USF 6UI 0.0004365 0.44758 32.8947
266 3RI1 3RH 0.0000001246 0.56267 32.9073
267 2HY0 306 0.000006833 0.56432 32.9193
268 3M2W L8I 0.00000000295 0.72505 33.1104
269 5UR1 YY9 0.000002822 0.43382 33.119
270 5UKL SIX 0.000000005633 0.6582 33.241
271 3PVW QRX 0.00000002749 0.58696 33.241
272 1JPA ANP 0.00001263 0.58127 33.3333
273 5DH3 5BS 0.000002336 0.55102 33.3333
274 5AX9 4KT 0.00001225 0.53205 33.4416
275 4I6H 1C8 0.0001171 0.4883 33.4416
276 5MJA 7O3 0.0000001151 0.63971 33.4426
277 2XVD AS6 0.0000001544 0.54062 33.4437
278 2ZV2 609 0.0000003127 0.63769 33.518
279 4XV1 904 0.000001865 0.56237 33.5616
280 2HK5 1BM 0.00000005558 0.62048 33.7037
281 4AG8 AXI 0.00006919 0.419 33.8608
282 4JR7 GNP 0.0000001185 0.62195 33.9572
283 5DEY 59T 0.000002235 0.41093 34.0067
284 4BHN BH9 0.000002514 0.54966 34.1317
285 3G5D 1N1 0.0000004361 0.41193 34.2657
286 4FG8 ATP 0.000000006471 0.66044 34.2857
287 4JDI ANP 0.00000000978 0.65277 34.3931
288 3GGF GVD 0.000003558 0.57017 34.5515
289 1CM8 ANP 0.000007666 0.5477 34.626
290 3ORK AGS 0.0000002129 0.56166 34.7267
291 3OFM 4B0 0.000000482 0.51668 34.8571
292 3SXF BK5 0.00000001024 0.53739 34.903
293 2PVN P63 0.00000001775 0.57536 34.9432
294 5FBN 5WF 0.000001258 0.47714 35.0554
295 4CQE CQE 0.000003359 0.53828 35.2518
296 2F57 23D 0.0000005619 0.60758 35.3312
297 5JKG 6LF 0.00008876 0.41088 35.3698
298 2Y6O 1N1 0.000003771 0.53618 35.3952
299 2WQN ADP 0.0000001273 0.64695 35.4839
300 3AQV TAK 0.001217 0.40624 35.5072
301 4Q5H ANP 0.000009815 0.53635 35.5263
302 4LOO SB4 0.000003104 0.55866 36.0111
303 5JZJ AN2 0.000000004363 0.69573 36.0269
304 4RFM 3P6 0.000004727 0.40496 36.0902
305 3SRV S19 0.0000001257 0.62913 36.1011
306 1PHK ATP 0.0000000008154 0.65183 36.2416
307 4CRL C1I 0.0000002411 0.50175 36.2881
308 3DLS ADP 0.000001486 0.5048 36.4179
309 2YAK OSV 0.0000000004862 0.6174 36.4912
310 4YMJ 4EJ 0.000005256 0.59885 36.5132
311 3GNI ATP 0.000000425 0.58269 36.5651
312 4M69 ANP 0.0000001284 0.60493 36.7412
313 5A6N U7E 0.000000002396 0.63669 36.7491
314 4NST ADP 0.0000004996 0.59406 36.7521
315 5TO8 7FM 0.000001145 0.45402 36.8794
316 3DAK ANP 0.0000000151 0.68088 36.8966
317 4XLI 1N1 0.000002489 0.56999 36.9403
318 1BYG STU 0.00000004734 0.65772 37.0504
319 4YZN 4K5 0.00000001303 0.63165 37.2822
320 3SXS PP2 0.000000779 0.57143 37.3134
321 2OFV 242 0.00003318 0.42531 37.5451
322 5EFQ ADP 0.000000137 0.61914 37.7522
323 4C2V YJA 0.000003262 0.48909 37.8947
324 5LVP ATP 0.0000001736 0.64051 37.9421
325 5H2U 1N1 0.00001339 0.53033 38.2022
326 2A19 ANP 0.0000003504 0.63527 38.3803
327 4G31 0WH 0.0002216 0.4088 38.4615
328 5DA3 58V 0.000001515 0.60415 38.4906
329 5EYK 5U5 0.0000003725 0.53664 39.1304
330 3SLS ANP 0.0000004595 0.5745 39.1447
331 5DRB 5FJ 0.00000123 0.42979 39.1753
332 1Q8Y ADP 0.00000000126 0.69084 39.3352
333 1Q8Y ADE 0.0000000577 0.68452 39.3352
334 4WNP 3RJ 0.0000007547 0.61003 39.3728
335 5G1X ADP 0.0000001171 0.63054 39.6491
336 5L8L ADP 0.0000004695 0.62905 39.6491
337 4KS7 X4Z 0.00000000829 0.63972 39.726
338 5UOX 8GY 0.000004175 0.53432 39.8524
339 5EKO N17 0.00002215 0.49887 39.8892
340 5LXM ADP 0.000001983 0.57449 39.9293
341 4WB6 ATP 0.00000007661 0.56918 40
342 4WB7 ATP 0.0000005766 0.48313 40
343 2GU8 796 0.00000001373 0.44445 40
344 2X4Z X4Z 0.000000004535 0.5501 40.2027
345 4L3L 5FI 0.00000006958 0.61712 40.4605
346 3E7O 35F 0.000006962 0.4595 40.8333
347 3IGO ANP 0.00000000412 0.66033 41.2742
348 4CSV STI 0.0004301 0.44592 41.8182
349 2Z7R STU 0.00000001554 0.63617 42.0561
350 4F9C 0SX 0.00000003807 0.6528 42.1053
351 3E5A VX6 0.00000572 0.50755 42.1642
352 3ALN ANP 0.0000002852 0.5901 42.2018
353 5AWM ANP 0.0000005534 0.62556 42.3823
354 4QTB 38Z 0.000000001499 0.6094 42.9363
355 4H3P ANP 0.000000001623 0.70511 43.2133
356 4UX9 ANP 0.000000004336 0.66788 43.2133
357 4IZY 1J2 0.0000003757 0.58498 43.2133
358 3TTI KBI 0.0000001324 0.55212 43.2133
359 3GC8 B45 0.00000464 0.5324 43.2133
360 3PTG 932 0.00003268 0.4411 43.2133
361 4WHZ 3NL 0.000001671 0.42261 43.2133
362 4H3Q ANP 0.000000002233 0.66313 43.4903
363 5BVE 4VG 0.00000002115 0.42238 43.4903
364 4AT3 LTI 0.000002449 0.49124 43.8127
365 1ZY5 ANP 0.000008447 0.54578 43.8944
366 4C2W ANP 0.0000007004 0.49688 44.2308
367 4NW6 2NS 0.0000004203 0.50539 44.8916
368 4NM5 ADP 0.0000003834 0.57128 45.4294
369 2JLD AG1 0.0000001232 0.52117 45.4294
370 2B9I ADP 0.00000000708 0.67656 45.6091
371 2B9J ADP 0.00000003278 0.65577 45.6091
372 2B9F ADP 0.00000004994 0.6387 45.6091
373 2B9H ADP 0.00000001501 0.60279 45.6091
374 3ZRM ZRM 0.000001982 0.56736 45.7064
375 5BYZ 4WE 0.00000003777 0.54365 46.5517
376 3F7Z 34O 0.0000007646 0.58582 47.1429
377 3GC0 AMP 0.00005937 0.51947 48.0243
378 3PE2 E1B 0.0000006632 0.59985 48.0712
379 5MY8 RXZ 0.000000005695 0.62016 48.4765
380 2BPM 529 0.00000001794 0.47049 48.8673
381 4CFU 2WC 0.000000609 0.60595 49.835
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