Receptor
PDB id Resolution Class Description Source Keywords
4UYH 1.73 Å NON-ENZYME: OTHER N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-((2R,4S)-2- METHYL-4-(PHENYLAMINO)-6-(4-(PIPERIDIN-1-YLMETHYL)PHENYL)- 3 ,4-DIHYDROQUINOLIN-1(2H)-YL)ETHANONE HOMO SAPIENS TRANSCRIPTION HISTONE EPIGENETIC READER BET BRD2 BROMOD
Ref.: THE DISCOVERY OF I-BET726 (GSK1324726A), A POTENT TETRAHYDROQUINOLINE APOA1 UP-REGULATOR AND SELECTIV BROMODOMAIN INHIBITOR. J.MED.CHEM. V. 57 8111 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SO4 B:1184;
Invalid;
none;
submit data
96.063 O4 S [O-]S...
DMS C:1182;
Invalid;
none;
submit data
78.133 C2 H6 O S CS(=O...
9S3 A:1184;
B:1183;
Valid;
Valid;
none;
none;
ic50 = 0.1995 uM
453.618 C30 H35 N3 O C[C@H...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2YDW 1.9 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD2 WIT INHIBITOR GW841819X HOMO SAPIENS NUCLEAR PROTEIN HISTONE EPIGENETIC READER
Ref.: DISCOVERY AND CHARACTERIZATION OF SMALL MOLECULE IN OF THE BET FAMILY BROMODOMAINS. J.MED.CHEM. V. 54 3827 2011
Members (14)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 4A9I - P9I C15 H13 N2 O C/C(=C/1C=....
2 4UYH ic50 = 0.1995 uM 9S3 C30 H35 N3 O C[C@H]1C[C....
3 4A9H - TVP C12 H15 N O C[C@H]1CCc....
4 4A9F - MB3 C5 H9 N O CN1CCCC1=O
5 4ALG ic50 = 0.5 uM 1GH C23 H21 N5 O3 Cc1c(c(on1....
6 2YEK ic50 = 32.5 nM EAM C22 H22 Cl N5 O2 CCNC(=O)C[....
7 2YDW ic50 = 29.9 nM WSH C25 H21 N5 O2 Cc1nnc2n1-....
8 4A9J - TYL C8 H9 N O2 CC(=O)Nc1c....
9 4A9M ic50 = 0.5 uM P9M C17 H22 N2 O3 S Cc1ccc(cc1....
10 4ALH - A9P C11 H11 N O Cc1c(c(on1....
11 4A9E - 3PF C9 H10 N2 O CN1Cc2cccc....
12 4A9O - A9O C12 H13 N O CCc1c(c(no....
13 4AKN ic50 = 0.79 uM S5B C25 H25 N3 O3 Cc1c(c(on1....
14 4A9N ic50 = 1.5 uM A9N C15 H16 N2 O3 S Cc1ccc(cc1....
70% Homology Family (166)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 4IOO - BAE C6 H13 N O CC(C)(C)C(....
2 5I88 ic50 = 0.46 uM 69G C20 H21 N3 O2 C/C=C/CN1C....
3 5DX4 ic50 = 0.41 uM E0C C20 H17 Br N2 O4 S CCN1c2ccc(....
4 3JVK Kd = 118 uM GLY GLY ALY ALA PRO ARG LYS GLN n/a n/a
5 4HBX ic50 = 1.9 uM 14X C13 H17 N3 O3 S CN1Cc2cc(c....
6 4NUE Ki = 0.15 uM NUE C19 H19 N5 O3 S Cc1cc(c(c(....
7 4HXR ic50 = 4.1 uM 1A4 C13 H10 N2 O3 S3 c1cc(cc(c1....
8 5TI5 ic50 = 41 uM 7CN C16 H13 Br N2 O3 S c1cc(cc(c1....
9 4O7C ic50 = 10 uM 2RK C22 H23 N5 O C1CNCCC1C2....
10 4IOQ - BAQ C4 H7 N O C1CC(=O)NC....
11 4HXK - 1AJ C11 H11 N3 O S c1csc2c1CN....
12 2YEL ic50 = 15.5 nM WSH C25 H21 N5 O2 Cc1nnc2n1-....
13 4BW4 ic50 = 631 nM 9B6 C22 H16 F3 N5 O4 Cc1c(c(on1....
14 4O72 ic50 = 1 uM 2R4 C25 H19 N O3 S c1ccc2c(c1....
15 5F63 Kd = 12 nM 5W2 C28 H35 Cl F N7 O3 S Cc1cnc(nc1....
16 5HLS ic50 = 0.039 uM 62G C20 H16 Cl N3 O2 Cc1c-2c(on....
17 4HBW ic50 = 4.8 uM 14Z C11 H15 N3 O3 S CCNS(=O)(=....
18 4OGI Kd = 37 nM R78 C28 H39 N7 O3 CC[C@@H]1C....
19 5TI7 ic50 = 11 uM 7CQ C17 H19 Br N2 O4 S COc1ccc(cc....
20 4J0S ic50 = 0.382 uM 1H3 C18 H17 N O3 Cc1c(c(on1....
21 4F3I ic50 = 0.03 uM 0S6 C20 H19 Cl N4 O2 S Cc1c(sc-2c....
22 4QZS Kd = 89 nM JQ1 C23 H26 Cl N4 O2 S Cc1c(sc-2c....
23 4WIV Kd = 550 nM 3P2 C21 H23 N5 O Cc1c(c(on1....
24 3P5O Kd = 50.5 nM EAM C22 H22 Cl N5 O2 CCNC(=O)C[....
25 4UIX ic50 = 50 nM TVU C22 H24 N2 O6 S2 CN1C=C(c2c....
26 4HXS ic50 = 4.1 uM 1A3 C16 H14 N2 O3 S2 c1ccc(cc1)....
27 5HM0 ic50 = 0.44 uM 62V C18 H13 Cl N2 O Cc1c-2c(on....
28 5DLX Kd = 2 uM 5D2 C25 H33 Cl N8 O Cc1nnc2n1n....
29 5TI2 ic50 = 24 uM 7CJ C16 H15 F N2 O3 S c1cc(cc(c1....
30 5D3H Kd = 7.9 uM 57G C20 H27 N3 O6 S CCc1c(c([n....
31 4MEP ic50 = 4.7 uM 24Y C19 H14 Cl N5 O Cc1cccnc1n....
32 4YH4 ic50 = 26 uM Y81 C20 H15 N3 O2 c1ccc(cc1)....
33 5D3N Kd = 9.2 uM L40 C18 H23 N3 O4 S CCc1c(c([n....
34 5D26 Kd = 0.81 uM L28 C19 H26 N4 O5 S CCc1c(c([n....
35 3MUK Kd = 380 uM ALA THR PRK ALA ALA ARG LYS SER n/a n/a
36 4J3I Kd = 8.93 uM 1K0 C20 H22 N2 O5 Cc1cc(cc(c....
37 4QB3 Kd = 3.4 uM 30M C17 H21 N3 O2 CC(=O)NCCC....
38 4LZS Kd = 16 uM L46 C11 H16 N2 O2 CCc1c(c([n....
39 4O71 ic50 = 18 uM CPB C21 H20 Cl N O5 C[N@]1CC[C....
40 4CFL Kd = 1.33 uM 8DQ C19 H18 N2 O2 c1ccc(cc1)....
41 4C67 - L5S C15 H12 N4 S Cc1nnc2n1-....
42 4QR3 ic50 = 1.4 uM BNJ C14 H16 N2 O3 S2 c1cc(cc(c1....
43 4ZC9 - 4MW C38 H37 Cl N8 O7 S Cc1c(sc-2c....
44 4MEO - 25V C18 H16 N2 O2 Cc1cc(c2cc....
45 4LRG ic50 = 0.026 uM 1XB C20 H18 Cl N3 O2 S Cc1c(sc-2c....
46 5TI3 ic50 = 44 uM 7CG C16 H14 Br2 N2 O3 S c1cc(cc(c1....
47 4HXP - 1A5 C10 H10 N2 O3 c1cc(ccc1C....
48 4O7E ic50 = 5.7 uM 2RN C20 H15 N3 O c1ccc(cc1)....
49 4O74 ic50 = 0.025 uM R78 C28 H39 N7 O3 CC[C@@H]1C....
50 4BW2 ic50 = 6.31 uM UTH C24 H24 N4 O3 Cc1c(c(on1....
51 5CS8 ic50 = 2.29 uM EB8 C21 H18 N2 O5 S CCN1c2ccc(....
52 3U5J Kd = 2.46 uM 08H C17 H13 Cl N4 Cc1nnc2n1-....
53 5EIS ic50 = 2.6 uM 5OU C14 H13 Cl N4 O2 CCn1cnc2c1....
54 3U5L Kd = 0.64 uM 08K C17 H14 Cl N5 Cc1nnc2n1-....
55 4QR4 ic50 = 0.25 uM BNK C14 H15 Cl N2 O3 S2 c1cc(c(cc1....
56 4O7A ic50 = 19 uM 2RF C16 H10 Cl2 N2 O3 c1cc(cc(c1....
57 5F61 Kd = 35 nM 5W0 C26 H34 F N7 O2 S Cc1cnc(nc1....
58 4HXN - 1A7 C9 H6 F N O S c1ccc(c(c1....
59 5TI4 ic50 = 26 uM 7CM C16 H14 Cl F N2 O3 S c1cc(cc(c1....
60 4NUD Ki < 0.0845 uM NUD C18 H17 N5 O3 S Cc1cc(c(cc....
61 4O7B ic50 = 20 uM 2RJ C26 H26 F N5 O Cc1cccc(c1....
62 5CPE ic50 = 0.45 uM EB2 C20 H24 N2 O3 S CCN1c2ccc(....
63 5DW2 Kd = 185 nM 5GD C24 H29 N3 O4 Cc1cc(cc(c....
64 5D3P Kd = 7.4 uM 57E C19 H21 N3 O4 S CCc1c(c([n....
65 4PCE ic50 = 7 uM 2N0 C17 H19 N O CCc1cc2c(n....
66 5D25 Kd = 0.46 uM 56M C19 H25 N3 O5 S CCN(CC)S(=....
67 5DLZ Kd = 1.8 uM 5D1 C28 H35 N3 O3 Cc1cccc(c1....
68 4J0R ic50 = 0.386 uM 1H2 C18 H17 N O3 Cc1c(c(on1....
69 5F60 Kd = 43 nM 5VZ C26 H34 Cl N7 O2 S Cc1cnc(nc1....
70 4HXO - 1A6 C11 H10 N4 O S Cc1cc(on1)....
71 5CRM ic50 = 1.09 uM EB5 C15 H16 N2 O3 S CCNS(=O)(=....
72 5CQT ic50 = 0.13 uM EB3 C19 H22 N2 O3 S CCN1c2ccc(....
73 5KHM Ki = 5.012 nM XNH C25 H33 N7 O3 C[C@@H]1C(....
74 4Z1S ic50 = 0.79 uM 559 C23 H21 Cl N6 Cc1nnc2n1-....
75 4MR3 - 1K0 C20 H22 N2 O5 Cc1cc(cc(c....
76 5ULA Ki = 77 nM 5MJ C20 H19 Cl N2 O3 CC1=C(CCC1....
77 4O78 ic50 = 4.6 uM SAV C21 H22 N6 O3 Cc1c2ccc(c....
78 4OGJ Kd = 164 nM 2TA C27 H36 N6 O3 S Cc1cnc(nc1....
79 5A85 ic50 = 3.98 uM 78J C21 H30 N4 O2 CC1=Cc2ccn....
80 5TI6 ic50 = 21 uM 7CO C16 H14 F2 N2 O3 S c1cc(cc(c1....
81 4MR4 - 1K0 C20 H22 N2 O5 Cc1cc(cc(c....
82 4QR5 ic50 = 0.06 uM BNM C18 H21 N3 O4 S2 c1c(cc(cc1....
83 4MEQ - 25O C12 H11 N5 Cc1cc(n2c(....
84 4O77 ic50 = 2.5 uM 2RE C20 H14 F N3 O c1cc(ccc1c....
85 5EI4 ic50 = 26.4 uM 5NV C17 H17 Cl N8 O2 S CCn1c(nc2c....
86 5CY9 ic50 = 0.73 uM E0A C17 H20 N2 O3 S CCCCS(=O)(....
87 5CRZ ic50 = 0.45 uM EB7 C19 H14 Cl F N2 O3 S CCN1c2ccc(....
88 5AD2 Kd = 63 nM ETU C24 H30 Cl N7 O2 C[C@@H]1C(....
89 4E96 ic50 = 0.22 uM 0NS C16 H17 N3 O4 S CN1Cc2cc(c....
90 5D0C ic50 = 3.18 uM E0B C21 H25 N3 O4 S CCN1c2ccc(....
91 4O7F ic50 = 13 uM 2RQ C25 H24 F N5 O2 COc1ccccc1....
92 5CP5 Kd = 1.234 uM EB0 C19 H15 F N2 O3 S CCN1c2ccc(....
93 4CFK Kd = 1.83 uM LY2 C19 H17 N O3 c1ccc(cc1)....
94 5D3R - 57C C23 H31 N3 O4 S CCCc1c(c([....
95 4NUC Ki = 0.91 uM 435 C19 H18 N4 O3 S Cc1cc(cc(c....
96 4HXL ic50 = 2.2 uM 1A9 C22 H25 N3 O4 S3 c1cc(sc1)S....
97 5D3L Kd = 0.88 uM 57F C21 H29 N3 O5 S CCc1c(c([n....
98 4A9L - P9L C14 H19 N3 O4 S CN1Cc2cc(c....
99 4XYA Kd = 1370 nM 43S C13 H8 Br N5 O c1coc2c1cc....
100 4C66 - H4C C17 H16 Cl N4 S CCc1cc2c(s....
101 4O76 ic50 = 0.13 uM 1M3 C26 H35 N7 O2 S Cc1cnc(nc1....
102 5LJ2 ic50 = 16 uM 6XW C25 H32 N6 O4 S CC1=Cc2c(c....
103 5I80 ic50 = 0.092 uM 67B C17 H17 N3 O2 CN1C=C(c2c....
104 4O75 ic50 = 21 uM 2RC C23 H26 F N6 O9 P CC1(C(=O)N....
105 3ZYU ic50 = 0.1 uM 1GH C23 H21 N5 O3 Cc1c(c(on1....
106 4Z1Q ic50 = 0.015 uM 558 C23 H21 Cl N6 Cc1nnc2n1-....
107 5IGK Kd = 41.8 nM BMF C17 H20 N6 O4 S CCOC(=O)Nc....
108 5KDH Ki = 0.37 uM 6RX C18 H17 N3 O4 CCN1C2=C([....
109 4PS5 ic50 = 0.29 uM 2TA C27 H36 N6 O3 S Cc1cnc(nc1....
110 5D24 Kd = 5.8 uM L26 C18 H21 N3 O4 CCc1c(c([n....
111 5ACY Kd = 6.4 nM 9S3 C30 H35 N3 O C[C@H]1C[C....
112 5HCL ic50 = 6 mM 5Y9 C4 H9 N O CC(=O)N(C)....
113 5COI ic50 = 2.58 uM 55K C20 H22 N2 O5 S CCN1c2ccc(....
114 4HXM ic50 = 0.79 uM 1A8 C17 H17 N3 O4 S3 CCCC(=O)Nc....
115 5F62 Kd = 6.8 nM 5W1 C26 H33 Cl F N7 O2 S Cc1cnc(nc1....
116 5D3S Kd = 1.3 uM 579 C20 H24 F N3 O5 S CCc1c(c([n....
117 4LYW Kd = 237 nM 21Q C20 H27 N3 O5 S CCc1c(c([n....
118 4HBV ic50 = 23 uM 15E C9 H9 Br N2 O CN1Cc2cc(c....
119 5LUU Kd = 8.63 uM 77X C15 H17 N3 O CCC(=O)N1C....
120 4YH3 ic50 = 26 uM Y80 C24 H20 N2 O3 COc1ccc(cc....
121 4X2I ic50 = 0.35 uM 3X0 C18 H17 Cl N4 Cc1nnc2n1-....
122 5F5Z Kd = 86 nM 5VY C26 H35 N7 O2 S Cc1cnc(nc1....
123 4HBY ic50 = 4.4 uM 13F C15 H15 N3 O3 S CN1Cc2cc(c....
124 5D3J Kd = 5.7 uM L33 C20 H27 N3 O4 S CCc1c(c([n....
125 3MUL - GLY GLY BTK ALA PRO ARG LYS GLN n/a n/a
126 4LR6 ic50 = 33 uM 1XA C10 H10 N2 O Cc1c(c(on1....
127 5AD3 Kd = 7.9 nM K6K C26 H30 N10 O3 CN(CCOc1cc....
128 4PCI ic50 = 7.5 uM 2NJ C16 H16 N2 O CN1c2ccccc....
129 5D3T Kd = 12 uM 56Y C19 H23 N3 O3 CCc1c(c([n....
130 5LJ1 ic50 = 6.3 uM 6XX C28 H35 F2 N5 O3 Cc1cc(cnc1....
131 4O70 ic50 = 19 uM 1QK C21 H29 N6 O2 CCc1cnn2c1....
132 4XY9 Kd = 7651 nM 43U C12 H10 Br N5 O COc1ccc(cc....
133 3MXF - JQ1 C23 H26 Cl N4 O2 S Cc1c(sc-2c....
134 5CFW Kd = 0.78 uM 53W C27 H32 N4 O3 Cc1c(c(on1....
135 5A5S ic50 = 1.3 uM NP8 C20 H23 N5 O2 CC1=Cc2c(c....
136 4UIY ic50 = 2.512 uM 5V2 C21 H20 F3 N3 O3 S2 CN1C=C(c2c....
137 4LZR Kd = 20 uM LOC C22 H25 N O6 CC(=O)N[C@....
138 4BW1 ic50 = 1.26 uM S5B C25 H25 N3 O3 Cc1c(c(on1....
139 4MEN - 25K C15 H17 N5 Cc1ccc(cc1....
140 4UIZ ic50 = 0.1995 uM N1D C22 H25 N3 O6 S2 CN1C=C(c2c....
141 5KJ0 ic50 = 130 nM 6TB C29 H41 N7 O3 CC[C@@H]1C....
142 4KV1 - THR PHE ALY SER ILE MET LYS n/a n/a
143 5EGU ic50 = 5 uM 5NQ C23 H32 N8 O2 S CCCCc1c(nc....
144 4BW3 ic50 = 501 nM 9BM C25 H26 N4 O4 Cc1c(c(on1....
145 3U5K - 08J C18 H13 Cl F N3 Cc1ncc2n1-....
146 4FLP Kd = 190 nM JQ1 C23 H26 Cl N4 O2 S Cc1c(sc-2c....
147 4KCX Kd = 37 uM 1QK C21 H29 N6 O2 CCc1cnn2c1....
148 4A9I - P9I C15 H13 N2 O C/C(=C/1C=....
149 4UYH ic50 = 0.1995 uM 9S3 C30 H35 N3 O C[C@H]1C[C....
150 4A9H - TVP C12 H15 N O C[C@H]1CCc....
151 4A9F - MB3 C5 H9 N O CN1CCCC1=O
152 4ALG ic50 = 0.5 uM 1GH C23 H21 N5 O3 Cc1c(c(on1....
153 2YEK ic50 = 32.5 nM EAM C22 H22 Cl N5 O2 CCNC(=O)C[....
154 2YDW ic50 = 29.9 nM WSH C25 H21 N5 O2 Cc1nnc2n1-....
155 4A9J - TYL C8 H9 N O2 CC(=O)Nc1c....
156 4A9M ic50 = 0.5 uM P9M C17 H22 N2 O3 S Cc1ccc(cc1....
157 4ALH - A9P C11 H11 N O Cc1c(c(on1....
158 4A9E - 3PF C9 H10 N2 O CN1Cc2cccc....
159 4A9O - A9O C12 H13 N O CCc1c(c(no....
160 4AKN ic50 = 0.79 uM S5B C25 H25 N3 O3 Cc1c(c(on1....
161 4A9N ic50 = 1.5 uM A9N C15 H16 N2 O3 S Cc1ccc(cc1....
162 4BJX ic50 = 22 nM 73B C25 H23 Cl N2 O3 C[C@H]1C[C....
163 4UYD ic50 = 79.4 uM V1T C10 H11 N3 O2 CN1c2ccc(c....
164 5WUU ic50 = 0.81 uM 7UU C18 H18 N2 O3 S CN(CCCNC1=....
165 5VOM ic50 = 0.79 uM 9GY C24 H23 N3 O4 C[C@H]1CN(....
166 3AQA - BYH C17 H16 N4 S2 CN1c2ccccc....
50% Homology Family (246)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 4IOO - BAE C6 H13 N O CC(C)(C)C(....
2 5I88 ic50 = 0.46 uM 69G C20 H21 N3 O2 C/C=C/CN1C....
3 5DX4 ic50 = 0.41 uM E0C C20 H17 Br N2 O4 S CCN1c2ccc(....
4 3JVK Kd = 118 uM GLY GLY ALY ALA PRO ARG LYS GLN n/a n/a
5 4HBX ic50 = 1.9 uM 14X C13 H17 N3 O3 S CN1Cc2cc(c....
6 4NUE Ki = 0.15 uM NUE C19 H19 N5 O3 S Cc1cc(c(c(....
7 4HXR ic50 = 4.1 uM 1A4 C13 H10 N2 O3 S3 c1cc(cc(c1....
8 5TI5 ic50 = 41 uM 7CN C16 H13 Br N2 O3 S c1cc(cc(c1....
9 4O7C ic50 = 10 uM 2RK C22 H23 N5 O C1CNCCC1C2....
10 4IOQ - BAQ C4 H7 N O C1CC(=O)NC....
11 4HXK - 1AJ C11 H11 N3 O S c1csc2c1CN....
12 2YEL ic50 = 15.5 nM WSH C25 H21 N5 O2 Cc1nnc2n1-....
13 4BW4 ic50 = 631 nM 9B6 C22 H16 F3 N5 O4 Cc1c(c(on1....
14 4O72 ic50 = 1 uM 2R4 C25 H19 N O3 S c1ccc2c(c1....
15 5F63 Kd = 12 nM 5W2 C28 H35 Cl F N7 O3 S Cc1cnc(nc1....
16 5HLS ic50 = 0.039 uM 62G C20 H16 Cl N3 O2 Cc1c-2c(on....
17 4HBW ic50 = 4.8 uM 14Z C11 H15 N3 O3 S CCNS(=O)(=....
18 4OGI Kd = 37 nM R78 C28 H39 N7 O3 CC[C@@H]1C....
19 5TI7 ic50 = 11 uM 7CQ C17 H19 Br N2 O4 S COc1ccc(cc....
20 4J0S ic50 = 0.382 uM 1H3 C18 H17 N O3 Cc1c(c(on1....
21 4F3I ic50 = 0.03 uM 0S6 C20 H19 Cl N4 O2 S Cc1c(sc-2c....
22 4QZS Kd = 89 nM JQ1 C23 H26 Cl N4 O2 S Cc1c(sc-2c....
23 4WIV Kd = 550 nM 3P2 C21 H23 N5 O Cc1c(c(on1....
24 3P5O Kd = 50.5 nM EAM C22 H22 Cl N5 O2 CCNC(=O)C[....
25 4UIX ic50 = 50 nM TVU C22 H24 N2 O6 S2 CN1C=C(c2c....
26 4HXS ic50 = 4.1 uM 1A3 C16 H14 N2 O3 S2 c1ccc(cc1)....
27 5HM0 ic50 = 0.44 uM 62V C18 H13 Cl N2 O Cc1c-2c(on....
28 5DLX Kd = 2 uM 5D2 C25 H33 Cl N8 O Cc1nnc2n1n....
29 5TI2 ic50 = 24 uM 7CJ C16 H15 F N2 O3 S c1cc(cc(c1....
30 5D3H Kd = 7.9 uM 57G C20 H27 N3 O6 S CCc1c(c([n....
31 4MEP ic50 = 4.7 uM 24Y C19 H14 Cl N5 O Cc1cccnc1n....
32 4YH4 ic50 = 26 uM Y81 C20 H15 N3 O2 c1ccc(cc1)....
33 5D3N Kd = 9.2 uM L40 C18 H23 N3 O4 S CCc1c(c([n....
34 5D26 Kd = 0.81 uM L28 C19 H26 N4 O5 S CCc1c(c([n....
35 3MUK Kd = 380 uM ALA THR PRK ALA ALA ARG LYS SER n/a n/a
36 4J3I Kd = 8.93 uM 1K0 C20 H22 N2 O5 Cc1cc(cc(c....
37 4QB3 Kd = 3.4 uM 30M C17 H21 N3 O2 CC(=O)NCCC....
38 4LZS Kd = 16 uM L46 C11 H16 N2 O2 CCc1c(c([n....
39 4O71 ic50 = 18 uM CPB C21 H20 Cl N O5 C[N@]1CC[C....
40 4CFL Kd = 1.33 uM 8DQ C19 H18 N2 O2 c1ccc(cc1)....
41 4C67 - L5S C15 H12 N4 S Cc1nnc2n1-....
42 4QR3 ic50 = 1.4 uM BNJ C14 H16 N2 O3 S2 c1cc(cc(c1....
43 4ZC9 - 4MW C38 H37 Cl N8 O7 S Cc1c(sc-2c....
44 4MEO - 25V C18 H16 N2 O2 Cc1cc(c2cc....
45 4LRG ic50 = 0.026 uM 1XB C20 H18 Cl N3 O2 S Cc1c(sc-2c....
46 5TI3 ic50 = 44 uM 7CG C16 H14 Br2 N2 O3 S c1cc(cc(c1....
47 4HXP - 1A5 C10 H10 N2 O3 c1cc(ccc1C....
48 4O7E ic50 = 5.7 uM 2RN C20 H15 N3 O c1ccc(cc1)....
49 4O74 ic50 = 0.025 uM R78 C28 H39 N7 O3 CC[C@@H]1C....
50 4BW2 ic50 = 6.31 uM UTH C24 H24 N4 O3 Cc1c(c(on1....
51 5CS8 ic50 = 2.29 uM EB8 C21 H18 N2 O5 S CCN1c2ccc(....
52 3U5J Kd = 2.46 uM 08H C17 H13 Cl N4 Cc1nnc2n1-....
53 5EIS ic50 = 2.6 uM 5OU C14 H13 Cl N4 O2 CCn1cnc2c1....
54 3U5L Kd = 0.64 uM 08K C17 H14 Cl N5 Cc1nnc2n1-....
55 4QR4 ic50 = 0.25 uM BNK C14 H15 Cl N2 O3 S2 c1cc(c(cc1....
56 4O7A ic50 = 19 uM 2RF C16 H10 Cl2 N2 O3 c1cc(cc(c1....
57 5F61 Kd = 35 nM 5W0 C26 H34 F N7 O2 S Cc1cnc(nc1....
58 4HXN - 1A7 C9 H6 F N O S c1ccc(c(c1....
59 5TI4 ic50 = 26 uM 7CM C16 H14 Cl F N2 O3 S c1cc(cc(c1....
60 4NUD Ki < 0.0845 uM NUD C18 H17 N5 O3 S Cc1cc(c(cc....
61 4O7B ic50 = 20 uM 2RJ C26 H26 F N5 O Cc1cccc(c1....
62 5CPE ic50 = 0.45 uM EB2 C20 H24 N2 O3 S CCN1c2ccc(....
63 5DW2 Kd = 185 nM 5GD C24 H29 N3 O4 Cc1cc(cc(c....
64 5D3P Kd = 7.4 uM 57E C19 H21 N3 O4 S CCc1c(c([n....
65 4PCE ic50 = 7 uM 2N0 C17 H19 N O CCc1cc2c(n....
66 5D25 Kd = 0.46 uM 56M C19 H25 N3 O5 S CCN(CC)S(=....
67 5DLZ Kd = 1.8 uM 5D1 C28 H35 N3 O3 Cc1cccc(c1....
68 4J0R ic50 = 0.386 uM 1H2 C18 H17 N O3 Cc1c(c(on1....
69 5F60 Kd = 43 nM 5VZ C26 H34 Cl N7 O2 S Cc1cnc(nc1....
70 4HXO - 1A6 C11 H10 N4 O S Cc1cc(on1)....
71 5CRM ic50 = 1.09 uM EB5 C15 H16 N2 O3 S CCNS(=O)(=....
72 5CQT ic50 = 0.13 uM EB3 C19 H22 N2 O3 S CCN1c2ccc(....
73 5KHM Ki = 5.012 nM XNH C25 H33 N7 O3 C[C@@H]1C(....
74 4Z1S ic50 = 0.79 uM 559 C23 H21 Cl N6 Cc1nnc2n1-....
75 4MR3 - 1K0 C20 H22 N2 O5 Cc1cc(cc(c....
76 5ULA Ki = 77 nM 5MJ C20 H19 Cl N2 O3 CC1=C(CCC1....
77 4O78 ic50 = 4.6 uM SAV C21 H22 N6 O3 Cc1c2ccc(c....
78 4OGJ Kd = 164 nM 2TA C27 H36 N6 O3 S Cc1cnc(nc1....
79 5A85 ic50 = 3.98 uM 78J C21 H30 N4 O2 CC1=Cc2ccn....
80 5TI6 ic50 = 21 uM 7CO C16 H14 F2 N2 O3 S c1cc(cc(c1....
81 4MR4 - 1K0 C20 H22 N2 O5 Cc1cc(cc(c....
82 4QR5 ic50 = 0.06 uM BNM C18 H21 N3 O4 S2 c1c(cc(cc1....
83 4MEQ - 25O C12 H11 N5 Cc1cc(n2c(....
84 4O77 ic50 = 2.5 uM 2RE C20 H14 F N3 O c1cc(ccc1c....
85 5EI4 ic50 = 26.4 uM 5NV C17 H17 Cl N8 O2 S CCn1c(nc2c....
86 5CY9 ic50 = 0.73 uM E0A C17 H20 N2 O3 S CCCCS(=O)(....
87 5CRZ ic50 = 0.45 uM EB7 C19 H14 Cl F N2 O3 S CCN1c2ccc(....
88 5AD2 Kd = 63 nM ETU C24 H30 Cl N7 O2 C[C@@H]1C(....
89 4E96 ic50 = 0.22 uM 0NS C16 H17 N3 O4 S CN1Cc2cc(c....
90 5D0C ic50 = 3.18 uM E0B C21 H25 N3 O4 S CCN1c2ccc(....
91 4O7F ic50 = 13 uM 2RQ C25 H24 F N5 O2 COc1ccccc1....
92 5CP5 Kd = 1.234 uM EB0 C19 H15 F N2 O3 S CCN1c2ccc(....
93 4CFK Kd = 1.83 uM LY2 C19 H17 N O3 c1ccc(cc1)....
94 5D3R - 57C C23 H31 N3 O4 S CCCc1c(c([....
95 4NUC Ki = 0.91 uM 435 C19 H18 N4 O3 S Cc1cc(cc(c....
96 4HXL ic50 = 2.2 uM 1A9 C22 H25 N3 O4 S3 c1cc(sc1)S....
97 5D3L Kd = 0.88 uM 57F C21 H29 N3 O5 S CCc1c(c([n....
98 4A9L - P9L C14 H19 N3 O4 S CN1Cc2cc(c....
99 4XYA Kd = 1370 nM 43S C13 H8 Br N5 O c1coc2c1cc....
100 4C66 - H4C C17 H16 Cl N4 S CCc1cc2c(s....
101 4O76 ic50 = 0.13 uM 1M3 C26 H35 N7 O2 S Cc1cnc(nc1....
102 5LJ2 ic50 = 16 uM 6XW C25 H32 N6 O4 S CC1=Cc2c(c....
103 5I80 ic50 = 0.092 uM 67B C17 H17 N3 O2 CN1C=C(c2c....
104 4O75 ic50 = 21 uM 2RC C23 H26 F N6 O9 P CC1(C(=O)N....
105 3ZYU ic50 = 0.1 uM 1GH C23 H21 N5 O3 Cc1c(c(on1....
106 4Z1Q ic50 = 0.015 uM 558 C23 H21 Cl N6 Cc1nnc2n1-....
107 5IGK Kd = 41.8 nM BMF C17 H20 N6 O4 S CCOC(=O)Nc....
108 5KDH Ki = 0.37 uM 6RX C18 H17 N3 O4 CCN1C2=C([....
109 4PS5 ic50 = 0.29 uM 2TA C27 H36 N6 O3 S Cc1cnc(nc1....
110 5D24 Kd = 5.8 uM L26 C18 H21 N3 O4 CCc1c(c([n....
111 5ACY Kd = 6.4 nM 9S3 C30 H35 N3 O C[C@H]1C[C....
112 5HCL ic50 = 6 mM 5Y9 C4 H9 N O CC(=O)N(C)....
113 5COI ic50 = 2.58 uM 55K C20 H22 N2 O5 S CCN1c2ccc(....
114 4HXM ic50 = 0.79 uM 1A8 C17 H17 N3 O4 S3 CCCC(=O)Nc....
115 5F62 Kd = 6.8 nM 5W1 C26 H33 Cl F N7 O2 S Cc1cnc(nc1....
116 5D3S Kd = 1.3 uM 579 C20 H24 F N3 O5 S CCc1c(c([n....
117 4LYW Kd = 237 nM 21Q C20 H27 N3 O5 S CCc1c(c([n....
118 4HBV ic50 = 23 uM 15E C9 H9 Br N2 O CN1Cc2cc(c....
119 5LUU Kd = 8.63 uM 77X C15 H17 N3 O CCC(=O)N1C....
120 4YH3 ic50 = 26 uM Y80 C24 H20 N2 O3 COc1ccc(cc....
121 4X2I ic50 = 0.35 uM 3X0 C18 H17 Cl N4 Cc1nnc2n1-....
122 5F5Z Kd = 86 nM 5VY C26 H35 N7 O2 S Cc1cnc(nc1....
123 4HBY ic50 = 4.4 uM 13F C15 H15 N3 O3 S CN1Cc2cc(c....
124 5D3J Kd = 5.7 uM L33 C20 H27 N3 O4 S CCc1c(c([n....
125 3MUL - GLY GLY BTK ALA PRO ARG LYS GLN n/a n/a
126 4LR6 ic50 = 33 uM 1XA C10 H10 N2 O Cc1c(c(on1....
127 5AD3 Kd = 7.9 nM K6K C26 H30 N10 O3 CN(CCOc1cc....
128 4PCI ic50 = 7.5 uM 2NJ C16 H16 N2 O CN1c2ccccc....
129 5D3T Kd = 12 uM 56Y C19 H23 N3 O3 CCc1c(c([n....
130 5LJ1 ic50 = 6.3 uM 6XX C28 H35 F2 N5 O3 Cc1cc(cnc1....
131 4O70 ic50 = 19 uM 1QK C21 H29 N6 O2 CCc1cnn2c1....
132 4XY9 Kd = 7651 nM 43U C12 H10 Br N5 O COc1ccc(cc....
133 3MXF - JQ1 C23 H26 Cl N4 O2 S Cc1c(sc-2c....
134 5CFW Kd = 0.78 uM 53W C27 H32 N4 O3 Cc1c(c(on1....
135 5A5S ic50 = 1.3 uM NP8 C20 H23 N5 O2 CC1=Cc2c(c....
136 4UIY ic50 = 2.512 uM 5V2 C21 H20 F3 N3 O3 S2 CN1C=C(c2c....
137 4LZR Kd = 20 uM LOC C22 H25 N O6 CC(=O)N[C@....
138 4BW1 ic50 = 1.26 uM S5B C25 H25 N3 O3 Cc1c(c(on1....
139 4MEN - 25K C15 H17 N5 Cc1ccc(cc1....
140 4UIZ ic50 = 0.1995 uM N1D C22 H25 N3 O6 S2 CN1C=C(c2c....
141 5KJ0 ic50 = 130 nM 6TB C29 H41 N7 O3 CC[C@@H]1C....
142 4KV1 - THR PHE ALY SER ILE MET LYS n/a n/a
143 5EGU ic50 = 5 uM 5NQ C23 H32 N8 O2 S CCCCc1c(nc....
144 4BW3 ic50 = 501 nM 9BM C25 H26 N4 O4 Cc1c(c(on1....
145 3U5K - 08J C18 H13 Cl F N3 Cc1ncc2n1-....
146 5MGJ Kd = 51 uM 7MX C9 H10 Cl N O3 CCOC(=O)C1....
147 5OR8 - JR4 C17 H18 F N3 O3 S Cc1cc2c(cc....
148 5FE0 - ALY C8 H16 N2 O3 CC(=O)NCCC....
149 5LVR Kd = 250 uM 78Y C10 H10 N4 O Cc1c(nn(n1....
150 5FDZ Kd = 6.8 uM 5X0 C21 H24 N2 O5 CNC(=O)c1c....
151 5FE1 - 12Q C10 H9 N O CN1c2ccccc....
152 5FE6 Kd = 6910 uM 5WZ C9 H16 N2 O C1CC1C(=O)....
153 5FE2 - 5WV C9 H9 N O CN1Cc2cccc....
154 5FE7 Kd = 488 uM 5WU C10 H14 N2 O2 Cc1c2c(n(n....
155 5FE8 - 5WT C13 H14 N2 O2 CC1=CC(=O)....
156 5FE4 - 5WY C9 H9 N O3 c1cc(c2c(c....
157 5FE9 Kd = 20.98 uM 5WS C12 H14 N2 O3 S CC1=CC(=O)....
158 5FE5 - 2QC C9 H9 N3 S c1cc(ccc1C....
159 5LVQ Kd = 73 uM 2LX C13 H17 N O3 CNC(=O)c1c....
160 5FE3 - 5WX C8 H8 N2 O2 COc1cccc2c....
161 3QZS Kd = 99 uM LYS GLY GLY ALA ALY ARG HIS ARG LYS VAL n/a n/a
162 3QZT - LYS GLY GLY ALA ALY ARG HIS ARG LYS VAL n/a n/a
163 2WP1 - LYS ALA PRO ARG ALY GLN LEU ALA THR LYS n/a n/a
164 4FLP Kd = 190 nM JQ1 C23 H26 Cl N4 O2 S Cc1c(sc-2c....
165 4KCX Kd = 37 uM 1QK C21 H29 N6 O2 CCc1cnn2c1....
166 4A9I - P9I C15 H13 N2 O C/C(=C/1C=....
167 4UYH ic50 = 0.1995 uM 9S3 C30 H35 N3 O C[C@H]1C[C....
168 4A9H - TVP C12 H15 N O C[C@H]1CCc....
169 4A9F - MB3 C5 H9 N O CN1CCCC1=O
170 4ALG ic50 = 0.5 uM 1GH C23 H21 N5 O3 Cc1c(c(on1....
171 2YEK ic50 = 32.5 nM EAM C22 H22 Cl N5 O2 CCNC(=O)C[....
172 2YDW ic50 = 29.9 nM WSH C25 H21 N5 O2 Cc1nnc2n1-....
173 4A9J - TYL C8 H9 N O2 CC(=O)Nc1c....
174 4A9M ic50 = 0.5 uM P9M C17 H22 N2 O3 S Cc1ccc(cc1....
175 4ALH - A9P C11 H11 N O Cc1c(c(on1....
176 4A9E - 3PF C9 H10 N2 O CN1Cc2cccc....
177 4A9O - A9O C12 H13 N O CCc1c(c(no....
178 4AKN ic50 = 0.79 uM S5B C25 H25 N3 O3 Cc1c(c(on1....
179 4A9N ic50 = 1.5 uM A9N C15 H16 N2 O3 S Cc1ccc(cc1....
180 4KV4 - THR PHE ALY SER ILE MET LYS n/a n/a
181 5UEZ Ki = 970 nM 89G C18 H16 N2 O3 CN1C(=O)C=....
182 5UF0 Ki = 160 uM 89J C12 H13 N3 O CNC1=CC(=O....
183 5UEU - 0S6 C20 H19 Cl N4 O2 S Cc1c(sc-2c....
184 4Z93 Ki = 12.2 nM 4LD C24 H23 N5 O2 Cc1c(c(n[n....
185 5UEY Ki = 5.1 nM 88M C22 H24 F2 N2 O5 S CCOC1=CC(=....
186 5UEX Ki = 1.5 nM 89D C24 H26 F2 N2 O5 S CCS(Nc1ccc....
187 5N18 Kd = 2.1 uM 8HZ C21 H19 N3 O Cc1ccc(cc1....
188 4BJX ic50 = 22 nM 73B C25 H23 Cl N2 O3 C[C@H]1C[C....
189 4UYD ic50 = 79.4 uM V1T C10 H11 N3 O2 CN1c2ccc(c....
190 4XUB ic50 = 1.07 uM 43D C19 H18 N8 Cc1cn(nn1)....
191 4XUA ic50 = 26 uM 43C C21 H18 N6 Cc1cn(nn1)....
192 5MGF Kd = 54 uM 7MW C9 H11 N O3 CCC(=O)c1c....
193 5E9I - F60 C8 H7 N O c1cc(cc2c1....
194 4NRB ic50 = 38 uM 2LX C13 H17 N O3 CNC(=O)c1c....
195 5MGG - 7MU C7 H7 Cl N2 O CNC(=O)c1c....
196 5ORB - JR6 C16 H19 N3 O2 S Cn1c(c2c(n....
197 4NRC ic50 = 241 uM 2LY C8 H9 N O3 S CNC(=O)c1c....
198 5E9K - 5KX C3 H3 Cl N2 c1cnc([nH]....
199 4NRA Kd = 65 uM 2LW C13 H13 Cl N2 O CC(=O)N1CC....
200 5MGE Kd = 87 uM 7MX C9 H10 Cl N O3 CCOC(=O)C1....
201 4NR9 - ALY C8 H16 N2 O3 CC(=O)NCCC....
202 5E9L - 6AI C7 H7 N3 c1cc2cn[nH....
203 5OR9 Kd = 88 uM JR5 C18 H21 F N4 O3 S Cn1c(c2c(n....
204 5E74 Kd = 39 uM 5KH C25 H19 F3 N2 O3 Cc1ccc(cc1....
205 5E9M - BAE C6 H13 N O CC(C)(C)C(....
206 5DYX - ADE C5 H5 N5 c1[nH]c2c(....
207 5DYU - MZ0 C4 H6 N2 O c1c([nH]cn....
208 5E73 Kd = 23 uM UO1 C19 H18 N2 O3 Cc1ccc(cc1....
209 5DBM ic50 = 0.35 uM 58N C17 H22 N4 O C[C@@H]1CC....
210 5LPM Kd = 2.77 uM 71Y C20 H23 Cl N2 O3 CCc1c(c([n....
211 5NRW - 96N C21 H22 N2 O2 CCc1c(c([n....
212 3P1D - MB3 C5 H9 N O CN1CCCC1=O
213 5LPJ Kd = 10.1 uM XDM C17 H19 Cl N2 O2 CCc1c(c([n....
214 4TQN Kd = 0.77 uM UL4 C18 H17 N O5 CCOc1ccc(c....
215 5TB6 Kd = 1.53 uM 77X C15 H17 N3 O CCC(=O)N1C....
216 5MQK - QPR C11 H11 N O CC(=O)c1cn....
217 5MQG - F31 C9 H11 N O2 CC(=O)c1cc....
218 5I83 ic50 = 4.1 uM 68Y C18 H20 N2 O2 C[C@@H]1CC....
219 4A9K - TYL C8 H9 N O2 CC(=O)Nc1c....
220 5I86 ic50 = 0.53 uM 69A C18 H19 N3 O2 C[C@@H]1CC....
221 5NU5 Kd = 0.47 uM 99E C21 H22 N2 O4 CCc1c(c([n....
222 5LPK Kd = 3.06 uM XDM C17 H19 Cl N2 O2 CCc1c(c([n....
223 5I89 ic50 = 0.033 uM 69B C21 H22 N4 O C[C@@H]1CC....
224 5NU3 Kd = 0.23 uM 99E C21 H22 N2 O4 CCc1c(c([n....
225 5J0D Kd = 134 nM 6F9 C27 H35 N3 O5 CCC(=O)N1C....
226 5CGP Kd = 0.12 uM 53W C27 H32 N4 O3 Cc1c(c(on1....
227 5DFD - 59E C23 H21 N5 O3 Cc1nnc2n1-....
228 5XHK - LDR C13 H9 N O c1ccc2c(c1....
229 5IG6 Kd = 213.7 uM 6B3 C27 H18 N2 O4 c1ccc2c(c1....
230 4J1P Kd = 0.206 uM 1K0 C20 H22 N2 O5 Cc1cc(cc(c....
231 5UEW - 87D C20 H20 N2 O5 S CN1C=C(C(=....
232 3ONI - JQ1 C23 H26 Cl N4 O2 S Cc1c(sc-2c....
233 4MR6 - 1K0 C20 H22 N2 O5 Cc1cc(cc(c....
234 5DW1 Kd = 185 nM 5GD C24 H29 N3 O4 Cc1cc(cc(c....
235 5DFC - EAM C22 H22 Cl N5 O2 CCNC(=O)C[....
236 4MR5 - 1K0 C20 H22 N2 O5 Cc1cc(cc(c....
237 5A7C ic50 = 0.00000001 M 5D4 C10 H20 N2 O2 CC(=O)NCCC....
238 5TPX Kd = 280 nM 7H7 C21 H24 N6 Cc1nnc2n1n....
239 5WUU ic50 = 0.81 uM 7UU C18 H18 N2 O3 S CN(CCCNC1=....
240 5N17 Kd = 4.8 uM 8FK C19 H18 N2 O3 S CN1c2ccc(c....
241 5N16 Kd = 5 uM 8FN C22 H15 N5 O2 S c1ccc2c(c1....
242 5VOM ic50 = 0.79 uM 9GY C24 H23 N3 O4 C[C@H]1CN(....
243 2YEM ic50 = 15.5 nM WSH C25 H21 N5 O2 Cc1nnc2n1-....
244 5JWM ic50 = 3.09 nM 6ON C54 H66 Cl2 N10 O9 S2 Cc1c(sc-2c....
245 5UOO ic50 = 7.2 nM 8FV C26 H21 N5 O2 Cc1c(c(on1....
246 3AQA - BYH C17 H16 N4 S2 CN1c2ccccc....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 9S3; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 9S3 1 1
2 73B 0.515789 0.633333
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2YDW; Ligand: WSH; Similar sites found: 10
This union binding pocket(no: 1) in the query (biounit: 2ydw.bio2) has 17 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3KPE TM3 0.01427 0.40475 None
2 3FUR Z12 0.004634 0.45487 3.26797
3 3H0A D30 0.008537 0.42241 7.84314
4 1GJW GLC 0.01724 0.40152 11.7647
5 3UVD MB3 0.00005117 0.51775 23.3871
6 5IGL BMF 0.00006803 0.45104 30.719
7 5LJ0 6XX 0.0000005812 0.62054 32.3077
8 5MG2 7M8 0.00006684 0.48444 34.3066
9 4YC9 4C1 0.0000006106 0.59253 35.2941
10 5I8G 69E 0.00000002234 0.68046 45.098
Pocket No.: 2; Query (leader) PDB : 2YDW; Ligand: WSH; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2ydw.bio2) has 15 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 2YDW; Ligand: WSH; Similar sites found: 409
This union binding pocket(no: 3) in the query (biounit: 2ydw.bio1) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1C1L GAL BGC 0.0003102 0.47396 None
2 3F81 STT 0.001319 0.46302 None
3 1SS4 CIT 0.002811 0.45859 None
4 2W3L DRO 0.001894 0.45542 None
5 1TU3 GNP 0.0004723 0.45539 None
6 2YC5 6BC 0.001835 0.44419 None
7 1TDF NAP 0.007749 0.44328 None
8 3QDT A2G GAL 0.003617 0.43379 None
9 3QDY A2G GAL 0.003807 0.43276 None
10 2JAR UMP 0.001059 0.43002 None
11 1TDF FAD 0.008308 0.42725 None
12 2OFE NAG 0.002498 0.42678 None
13 2F01 BTN 0.02693 0.41566 None
14 2F01 BTQ 0.02693 0.41566 None
15 3A2Q ACA ACA 0.00233 0.41465 None
16 2Q1A 2KT 0.005327 0.4127 None
17 1QJC PNS 0.02297 0.41205 None
18 1VQ2 DDN 0.002729 0.41201 None
19 4NAT ADP 0.04605 0.41159 None
20 2IYG FMN 0.0009892 0.41041 None
21 4NAT 2W5 0.01411 0.40906 None
22 2DTX BMA 0.01669 0.40791 None
23 3R35 4CO 0.01176 0.40576 None
24 4KQI NIO 0.01367 0.40305 None
25 4KQI RBZ 0.01367 0.40305 None
26 3VPD ANP 0.006684 0.40262 None
27 3IU9 T07 0.03376 0.40755 0.653595
28 1X1T NAD 0.01937 0.42505 1.30719
29 3WO0 ALA 0.008193 0.41801 1.30719
30 3WO0 ADP 0.008193 0.41801 1.30719
31 1HDR NAD 0.000289 0.49262 1.96078
32 3GEG NAD 0.001365 0.44002 1.96078
33 1B8U OAA 0.002695 0.43349 1.96078
34 1SQ5 PAU 0.00106 0.42937 1.96078
35 2QCX PF1 0.001728 0.42703 1.96078
36 1NN5 ANP 0.00353 0.42602 1.96078
37 1NN5 2DT 0.00353 0.42602 1.96078
38 2Q2V NAD 0.004487 0.42555 1.96078
39 3B20 NAD 0.004427 0.41628 1.96078
40 3HZS M0E 0.01735 0.40903 1.96078
41 3HY3 10F 0.005833 0.40834 1.96078
42 2PT9 2MH 0.01573 0.40393 1.96078
43 3T31 FAD 0.002603 0.45508 2.61438
44 3T31 DCQ 0.002821 0.45508 2.61438
45 1U7Z PMT 0.0008812 0.45494 2.61438
46 1Y9Q MED 0.0008864 0.44604 2.61438
47 1YOE RIB 0.002478 0.43093 2.61438
48 1R6W 164 0.001849 0.41629 2.61438
49 4K5S PM0 0.01624 0.41613 2.61438
50 4K5S FAD 0.007555 0.41613 2.61438
51 2X61 NGA GAL SIA 0.02955 0.40952 2.61438
52 2X61 CH 0.01088 0.40952 2.61438
53 4B9E FAH 0.009169 0.40852 2.61438
54 3ZRR PXG 0.006395 0.40159 2.61438
55 4PO2 ASN ARG LEU LEU LEU THR GLY 0.009445 0.40152 2.61438
56 4F8L GAL 0.006902 0.44601 2.75862
57 1NVU GTP 0.001315 0.4682 3.26797
58 2GSD NAD 0.000874 0.45768 3.26797
59 3G9E RO7 0.003432 0.45449 3.26797
60 3FC2 IBI 0.001205 0.44518 3.26797
61 1QW9 KHP 0.0009808 0.44263 3.26797
62 1X54 4AD 0.001291 0.43616 3.26797
63 1T26 GBD 0.01952 0.43371 3.26797
64 1T26 NAI 0.01952 0.43371 3.26797
65 1JA9 NDP 0.01424 0.43004 3.26797
66 1OAA OAA 0.00855 0.42409 3.26797
67 2QA1 FAD 0.006875 0.42013 3.26797
68 3NKS ACJ 0.001513 0.41962 3.26797
69 1F5F DHT 0.0001192 0.41938 3.26797
70 1Q3Q ANP 0.01891 0.41823 3.26797
71 3ZS7 ATP 0.002982 0.41822 3.26797
72 3Q9T FAY 0.009503 0.41737 3.26797
73 4KS1 2H8 0.01336 0.41571 3.26797
74 1GEX PLP HSA 0.004664 0.41537 3.26797
75 3BK2 U5P 0.001603 0.41379 3.26797
76 3Q3C NAD 0.02078 0.41363 3.26797
77 3NKS FAD 0.01107 0.41354 3.26797
78 2GWD GLU 0.001138 0.41055 3.26797
79 3CKZ ZMR 0.01627 0.41023 3.26797
80 2ZI8 SDT 0.00815 0.40978 3.26797
81 4NES UDP 0.003659 0.4071 3.26797
82 2GJ3 FAD 0.01057 0.40706 3.26797
83 1KDK DHT 0.007489 0.40238 3.26797
84 3FSY SCA 0.009922 0.41503 3.91566
85 3S9K CIT 0.003959 0.47116 3.92157
86 1Q0H NDP 0.001265 0.46372 3.92157
87 4G1V FAD 0.000893 0.44591 3.92157
88 1I0Z OXM 0.002997 0.44578 3.92157
89 1RYI FAD 0.002757 0.44332 3.92157
90 2XK9 XK9 0.001932 0.44202 3.92157
91 2IZ1 ATR 0.001491 0.43637 3.92157
92 2C7G ODP 0.007726 0.43415 3.92157
93 1RYI GOA 0.005791 0.4314 3.92157
94 1CKN GTP 0.0003221 0.43041 3.92157
95 1EDO NAP 0.01563 0.42819 3.92157
96 2C31 TZD 0.01716 0.42802 3.92157
97 2V6O FAD 0.01783 0.4278 3.92157
98 2C31 ADP 0.0234 0.42127 3.92157
99 3WBF NAP 0.004776 0.41928 3.92157
100 4COQ SAN 0.003848 0.41875 3.92157
101 2ZWS PLM 0.02243 0.41861 3.92157
102 4M5P MLA 0.01683 0.41687 3.92157
103 2AE2 NAP 0.01086 0.41685 3.92157
104 2AE2 PTO 0.01086 0.41685 3.92157
105 1QPB TPP 0.005188 0.41499 3.92157
106 1Q0H FOM 0.01577 0.41428 3.92157
107 3WBF API 0.008961 0.41303 3.92157
108 4NAO AKG 0.008269 0.41053 3.92157
109 1CKM GTP 0.002353 0.41008 3.92157
110 1DXY NAD 0.0071 0.40947 3.92157
111 3WD1 ST7 0.01888 0.40919 3.92157
112 3DAG FEG 0.006643 0.40918 3.92157
113 3RO7 TDR 0.008843 0.40699 3.92157
114 4M5P 23W 0.01367 0.40697 3.92157
115 2WGC SIA GAL BGC 0.03736 0.40665 3.92157
116 4BAS GNP 0.005379 0.40634 3.92157
117 2ZJ5 ADP 0.006187 0.40417 3.92157
118 1H6C NDP 0.02106 0.40166 3.92157
119 2PUL ACP 0.004604 0.40114 3.92157
120 2YFT DQR 0.004903 0.4001 3.92157
121 1H8G CHT 0.04391 0.40284 4.21053
122 3MBG FAD 0.009815 0.40234 4.31655
123 3F3E LEU 0.0001222 0.49616 4.57516
124 2YVF FAD 0.001953 0.46443 4.57516
125 1QY1 PRZ 0.0002327 0.45996 4.57516
126 4O8A FAD 0.0007333 0.45548 4.57516
127 3TKA CTN 0.005126 0.45085 4.57516
128 3O7B SAH 0.0003166 0.45035 4.57516
129 2YVF NAD 0.004919 0.44717 4.57516
130 1R6D DAU 0.004597 0.4426 4.57516
131 1R6D NAD 0.005232 0.4409 4.57516
132 4LHM AZZ 0.001182 0.43383 4.57516
133 1P9B IMO 0.001904 0.4294 4.57516
134 1TIW FAD 0.005937 0.42604 4.57516
135 1TIW TFB 0.005937 0.42604 4.57516
136 9LDB NAD 0.003856 0.42577 4.57516
137 1JIL 485 0.001749 0.4236 4.57516
138 9LDT NAD 0.004634 0.42248 4.57516
139 4IAE 1DX 0.01253 0.42147 4.57516
140 4C0C WVH 0.01038 0.42133 4.57516
141 2BLE 5GP 0.01782 0.42071 4.57516
142 4N4J HG1 0.008882 0.4201 4.57516
143 2J8Z NAP 0.004912 0.41879 4.57516
144 1V35 NAI 0.01206 0.41583 4.57516
145 3LPF Z77 0.005325 0.41454 4.57516
146 1T0I FMN 0.0028 0.41364 4.57516
147 1ZFJ IMP 0.01498 0.41355 4.57516
148 1TUF AZ1 0.004906 0.41294 4.57516
149 1KTC NGA 0.002764 0.4128 4.57516
150 4KCF AKM 0.004622 0.41236 4.57516
151 1RM4 NDP 0.02899 0.41118 4.57516
152 4NE2 SH2 0.01616 0.4045 4.57516
153 2DDH HXD 0.006001 0.40447 4.57516
154 4N02 FNR 0.03365 0.40429 4.57516
155 3BW2 FMN 0.01249 0.40345 4.57516
156 1SSQ CYS 0.02944 0.40281 4.57516
157 1LL2 UPG 0.007069 0.40166 4.57516
158 4NE2 ADP 0.01826 0.4012 4.57516
159 4KCT FDP 0.00199 0.40046 4.57516
160 3UEC ALA ARG TPO LYS 0.0006851 0.45867 4.79452
161 4LSJ LSJ 0.0003138 0.45486 5.22876
162 2YYJ 4HP 0.009893 0.44279 5.22876
163 2YYJ FAD 0.009893 0.44279 5.22876
164 3MAG 3MA 0.005999 0.43966 5.22876
165 2R14 TXD 0.001913 0.43832 5.22876
166 1M5B BN1 0.007486 0.43621 5.22876
167 2R14 FMN 0.002006 0.4317 5.22876
168 1XOC VAL ASP SER LYS ASN THR SER SER TRP 0.005784 0.42855 5.22876
169 4RJK PYR 0.005136 0.42673 5.22876
170 2NX1 PEP 0.003 0.42611 5.22876
171 3MPI GRA 0.01292 0.42352 5.22876
172 4C0X AQN 0.004793 0.42187 5.22876
173 4C0X FMN 0.004162 0.41887 5.22876
174 2CKM AA7 0.01069 0.41808 5.22876
175 2NX1 RP5 0.005013 0.41703 5.22876
176 1ZK4 NAP 0.03401 0.41683 5.22876
177 1ZK4 AC0 0.03401 0.41683 5.22876
178 4G09 0VD 0.001954 0.41537 5.22876
179 4HA6 PXM 0.0002933 0.41427 5.22876
180 3LN9 FLC 0.02114 0.41252 5.22876
181 2DKH FAD 0.01026 0.41058 5.22876
182 4C6F NCD 0.001672 0.41045 5.22876
183 4C6F DOR 0.001672 0.41045 5.22876
184 2QJN KDG 0.002639 0.40808 5.22876
185 1H2B NAJ 0.01196 0.40779 5.22876
186 2GDZ NAD 0.01035 0.40681 5.22876
187 4AF0 MOA 0.007281 0.40606 5.22876
188 2JFV FLC 0.007961 0.40521 5.22876
189 4AF0 IMP 0.03135 0.40276 5.22876
190 2PTZ PAH 0.004354 0.40207 5.22876
191 4CS4 ANP 0.001281 0.45312 5.47445
192 4CS4 AXZ 0.01063 0.42001 5.47445
193 2AEB ABH 0.009677 0.40258 5.59006
194 1G0N PHH 0.001461 0.45512 5.88235
195 4JK3 NAD 0.0009 0.4489 5.88235
196 4GYW UDP 0.001767 0.44109 5.88235
197 3PC3 P1T 0.0008244 0.43838 5.88235
198 2HV8 GTP 0.001173 0.43782 5.88235
199 2HW1 ANP 0.001024 0.43467 5.88235
200 4MZ7 DGT 0.002319 0.43351 5.88235
201 2VJJ RAM GLC GAL NAG NAG GLC 0.00764 0.4309 5.88235
202 4MZ7 DTP 0.003083 0.42844 5.88235
203 3K37 BCZ 0.03135 0.41749 5.88235
204 4WNB 4BN 0.002012 0.41711 5.88235
205 2IXB A2G 0.01177 0.41341 5.88235
206 1RZM PEP 0.002751 0.41289 5.88235
207 1G0N NDP 0.01214 0.41284 5.88235
208 2IXB NAD 0.008845 0.41087 5.88235
209 1M7Y PPG 0.008486 0.41036 5.88235
210 2Q8M FBP 0.002653 0.4103 5.88235
211 1RKD ADP 0.01099 0.40817 5.88235
212 1RKD RIB 0.01099 0.40817 5.88235
213 4L7I SAM 0.0003508 0.4028 5.88235
214 3RKR NAP 0.002787 0.40219 5.88235
215 2VAR ANP 0.007391 0.4009 5.88235
216 4UBP HAE 0.007181 0.40052 5.88235
217 1QRD FAD 0.009384 0.40009 5.88235
218 2OD9 A1R NCA 0.009684 0.408 6.16883
219 2QLX RM4 0.001211 0.44767 6.48148
220 4E28 9MZ 0.0006043 0.45315 6.53595
221 4E28 0MZ 0.0005289 0.44823 6.53595
222 4W97 UCA 0.001297 0.43607 6.53595
223 4AAW R84 0.00669 0.43219 6.53595
224 1ZZ7 S0H 0.0009446 0.43137 6.53595
225 1LYX PGA 0.0007998 0.42773 6.53595
226 2H6B 3C4 0.01408 0.42258 6.53595
227 3P0K FAD 0.003345 0.41625 6.53595
228 3PVT 3HC 0.01397 0.40924 6.53595
229 1JCM 137 0.009407 0.40723 6.53595
230 1BUC CAA 0.009659 0.40113 6.53595
231 2YB9 HA0 0.0003608 0.46666 7.18954
232 1UXG NAD 0.0009193 0.46037 7.18954
233 1UXG FUM 0.0009193 0.46037 7.18954
234 3RFV NAI 0.00052 0.45704 7.18954
235 1NU4 MLA 0.002725 0.45703 7.18954
236 2BJK NAD 0.002954 0.45146 7.18954
237 4TMK T5A 0.01466 0.44497 7.18954
238 1MDZ PLP 0.001565 0.44327 7.18954
239 3QP6 HL6 0.0003252 0.44254 7.18954
240 3OIG NAD 0.005982 0.44197 7.18954
241 3OND ADN 0.004824 0.43839 7.18954
242 3OND NAD 0.004824 0.43839 7.18954
243 1XX4 BAM 0.004411 0.43765 7.18954
244 4FR3 0V4 0.01485 0.42978 7.18954
245 4FR3 LYS ARG ARG LYS SEP VAL 0.01485 0.42978 7.18954
246 3K9W ADE 0.03639 0.42127 7.18954
247 3K9W 4PS 0.03639 0.42127 7.18954
248 4P3H 25G 0.01076 0.42065 7.18954
249 1H0C AOA 0.005208 0.41948 7.18954
250 3S7O LBV 0.007164 0.41466 7.18954
251 3OIG IMJ 0.009273 0.41241 7.18954
252 1MDZ DCS 0.01002 0.41101 7.18954
253 1UMP SQA 0.006011 0.41093 7.18954
254 4WVH ASP HIS ASP ALA HIS ALA 0.002772 0.40734 7.18954
255 4KQL 1SG 0.03768 0.40722 7.18954
256 1D3V ABH 0.009027 0.4038 7.18954
257 2D0V PQQ 0.005689 0.40358 7.18954
258 2VHJ ADP 0.006269 0.40193 7.18954
259 3RFV 15L 0.01134 0.40122 7.18954
260 1EP2 ORO 0.0009038 0.45579 7.27969
261 1EP2 FMN 0.004464 0.41909 7.27969
262 1EP2 FAD 0.004911 0.41131 7.27969
263 1H6W SER LEU ASN TYR ILE ILE LYS VAL LYS GLU 0.001704 0.45943 7.84314
264 2Q8H TF4 0.00165 0.45832 7.84314
265 1KBI FMN 0.0009884 0.44413 7.84314
266 1KBI PYR 0.0009884 0.44413 7.84314
267 4OYA 1VE 0.01314 0.44359 7.84314
268 1JQI FAD 0.003597 0.43308 7.84314
269 3T1A 5MA 0.001391 0.42543 7.84314
270 4IVG ANP 0.01073 0.42482 7.84314
271 1LC8 33P 0.003125 0.42391 7.84314
272 4DQ2 BTX 0.003988 0.42249 7.84314
273 1FM9 570 0.01298 0.42139 7.84314
274 2NLI FMN 0.01957 0.41332 7.84314
275 2NLI LAC 0.01957 0.41332 7.84314
276 2VDJ HSE 0.01076 0.4118 7.84314
277 1PR9 NAP 0.01005 0.41096 7.84314
278 1V9N NDP 0.009633 0.41055 7.84314
279 3PJU C2E 0.006688 0.41052 7.84314
280 1WDA BAG 0.002351 0.4101 7.84314
281 3TO7 COA 0.01407 0.4101 7.84314
282 1JQI CAA 0.007072 0.40657 7.84314
283 2V5E SCR 0.002019 0.46363 7.92079
284 5FIT AP2 0.001304 0.41716 8.16327
285 1ML4 PAL 0.007049 0.40083 8.44156
286 2G86 UMP 0.001552 0.46076 8.49673
287 2XCG XCG 0.001058 0.44749 8.49673
288 1DR1 NAP 0.003263 0.43598 8.49673
289 1DR1 HBI 0.003263 0.43598 8.49673
290 3CL7 HYN 0.002547 0.42434 8.49673
291 1Z44 NPO 0.01849 0.42312 8.49673
292 4MWV BCZ 0.007659 0.42031 8.49673
293 2HGS ADP 0.002969 0.4183 8.49673
294 1XNK XS2 0.001719 0.4175 8.49673
295 3QV9 QV7 0.003395 0.41494 8.49673
296 3QO8 SSA 0.002382 0.41208 8.49673
297 3OZG SSI 0.002478 0.41143 8.49673
298 4GQB 0XU 0.02581 0.40944 8.49673
299 3LIH RAF 0.00532 0.40282 8.49673
300 4NM5 ADP 0.007779 0.40172 8.49673
301 1ZK7 FAD 0.0009315 0.46758 9.15033
302 3M0J OAF 0.001309 0.44511 9.15033
303 2YPO PHE 0.001255 0.44445 9.15033
304 3E5P PPI 0.02201 0.43932 9.15033
305 1C3V NDP 0.00183 0.43911 9.15033
306 2XVE FAD 0.01545 0.42479 9.15033
307 1E2S CSN 0.002055 0.4122 9.15033
308 3LST SAH 0.002687 0.40779 9.15033
309 1BTN I3P 0.01544 0.42581 9.43396
310 3D3W NAP 0.0009371 0.45109 9.80392
311 3IB8 AMP 0.0006055 0.43231 9.80392
312 2XDQ MGX 0.009156 0.42227 9.80392
313 4LXH C1E 0.001931 0.41779 9.80392
314 4A3R CIT 0.007954 0.41747 9.80392
315 2QDT I38 0.002418 0.41184 9.80392
316 2BNF UTP 0.01388 0.41037 9.80392
317 1V1A KDG 0.004323 0.40917 9.80392
318 4CCO OGA 0.003882 0.40693 9.80392
319 2BGM MAX 0.00758 0.40536 9.80392
320 2WQP WQP 0.009583 0.40418 9.80392
321 3PNL ADP 0.007624 0.40207 9.80392
322 1Y75 NAG 0.00029 0.44505 10.1695
323 2E2R 2OH 0.0005022 0.46644 10.4575
324 1T0S BML 0.002744 0.43936 10.4575
325 2J07 FAD 0.005794 0.43575 10.4575
326 2J07 HDF 0.005794 0.43575 10.4575
327 1IM8 SAI 0.001978 0.42344 10.4575
328 1E7S NAP 0.006465 0.41774 10.4575
329 2B82 ADN 0.003094 0.41579 10.4575
330 4HZD COA 0.009466 0.41429 10.4575
331 1WVG APR 0.005749 0.41171 10.4575
332 1Z45 NAD 0.008074 0.41125 10.4575
333 1WVG CXY 0.005015 0.40928 10.4575
334 4W6Z 8ID 0.00165 0.44732 11.1111
335 1H9G COA MYR 0.001495 0.43687 11.1111
336 2ZX7 ZX7 0.002503 0.43283 11.1111
337 1LDM NAD 0.0118 0.43134 11.1111
338 2ZJ3 G6P 0.00294 0.41479 11.1111
339 4PLG OXM 0.0142 0.40894 11.1111
340 4PLG NAI 0.0142 0.40894 11.1111
341 3SQG TP7 0.003402 0.40617 11.1111
342 1BGQ RDC 0.0006548 0.45136 11.7647
343 2R40 20E 0.0009524 0.44144 11.7647
344 2R40 EPH 0.001845 0.43829 11.7647
345 1N6B DMZ 0.008252 0.41894 11.7647
346 2JC9 ADN 0.0008451 0.40898 11.7647
347 3ZLM ANP 0.003751 0.40871 11.7647
348 2JBH 5GP 0.002884 0.40668 11.7647
349 1QF5 GDP 0.003175 0.44631 12.4183
350 1QF5 RPL 0.003175 0.44631 12.4183
351 1LVL FAD 0.0032 0.4425 12.4183
352 1GSA ADP 0.0188 0.41255 12.4183
353 4CMF PXG 0.02215 0.41093 12.4183
354 1GSA GSH 0.02065 0.40577 12.4183
355 4EPL JAI 0.004763 0.40058 12.4183
356 4R3L COA 0.002824 0.41036 12.7168
357 1JSH SIA GAL 0.001884 0.42611 13.0682
358 1YBH FAD 0.003014 0.4396 13.0719
359 2VBQ BSJ 0.002529 0.43715 13.0719
360 2Q1S NAI 0.004403 0.43653 13.0719
361 3BAZ NAP 0.004938 0.41437 13.0719
362 1WUR 8DG 0.004743 0.41024 13.0719
363 4Q3R XA2 0.007074 0.40808 13.0719
364 2B4Q NAP 0.009731 0.40791 13.0719
365 1RY2 AMP 0.01079 0.40067 13.0719
366 2AMV BIN 0.005926 0.43615 13.7255
367 2YHW BM3 0.003588 0.42573 13.7255
368 1XHL NDP 0.004476 0.42436 13.7255
369 2J0W ADP 0.00243 0.41395 13.7255
370 3SSO SAH 0.003897 0.41185 13.7255
371 1GV0 NAD 0.009134 0.40905 13.7255
372 3O03 NAP 0.01035 0.40282 13.7255
373 3LZW NAP 0.0125 0.42696 14.3791
374 3LZW FAD 0.0103 0.41588 14.3791
375 3NYQ MCA 0.008823 0.41213 14.3791
376 3NYQ AMP 0.01001 0.41102 14.3791
377 4OJ8 AKG 0.004377 0.40803 14.3791
378 2JBZ COA 0.01278 0.41868 14.6853
379 4M51 BEZ 0.003281 0.43576 15.0327
380 1KOL NAD 0.005017 0.42699 15.0327
381 1R37 NAD 0.005151 0.42424 15.0327
382 3AHC TPP 0.008388 0.41057 15.0327
383 2Y7P SAL 0.003166 0.41046 15.0327
384 3WE0 FAD 0.0002507 0.49011 15.6863
385 1D6H COA 0.002778 0.44515 15.6863
386 3MMR ABH 0.005452 0.41264 15.6863
387 1A8R GTP 0.003637 0.41118 15.6863
388 1LTH NAD 0.03305 0.40464 15.6863
389 2F2U M77 0.003051 0.40073 15.6863
390 1FP1 SAH 0.000722 0.43189 16.3399
391 1R27 MGD 0.0128 0.40982 16.3399
392 1QS8 IVA VAL VAL STA ALA STA 0.0006208 0.43902 16.9935
393 3EE4 MYR 0.002565 0.419 16.9935
394 1VDC FAD 0.003783 0.44299 17.6471
395 1EXB NDP 0.009646 0.43893 17.6471
396 1FIQ FAD 0.003046 0.43377 17.6471
397 1P72 ADP 0.005501 0.4194 17.6471
398 4AT0 FAD 0.03504 0.40063 17.6471
399 3K3K A8S 0.001103 0.43142 18.3007
400 1EZV SMA 0.006658 0.4106 18.9189
401 2HVW DCP 0.003629 0.40284 18.9542
402 1MVN PCO 0.04361 0.40156 20.915
403 1DLJ UGA 0.007527 0.43158 21.5686
404 3TN7 NJP 0.01495 0.40144 21.5686
405 1GS5 ANP 0.002107 0.4392 22.2222
406 1GS5 NLG 0.002107 0.4392 22.2222
407 1SB8 UD2 0.002934 0.45119 23.5294
408 1SB8 NAD 0.02243 0.40918 23.5294
409 2CE7 ADP 0.002508 0.40892 25.4902
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