Receptor
PDB id Resolution Class Description Source Keywords
4RYV 1.38 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF YELLOW LUPIN LLPR-10.1A PROTEIN IN COMP TRANS-ZEATIN LUPINUS LUTEUS PR-10 FOLD LIGAND BINDING PHYTOHORMONE BINDING PROTEIN TRZEATIN CYTOKININ PLANT PROTEIN
Ref.: CRYSTALLOGRAPHIC AND CD PROBING OF LIGAND-INDUCED CONFORMATIONAL CHANGES IN A PLANT PR-10 PROTEIN. J.STRUCT.BIOL. V. 193 55 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ZEA A:204;
A:203;
A:205;
A:202;
A:201;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
submit data
219.243 C10 H13 N5 O C/C(=...
SO4 A:206;
Invalid;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4RYV 1.38 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF YELLOW LUPIN LLPR-10.1A PROTEIN IN COMP TRANS-ZEATIN LUPINUS LUTEUS PR-10 FOLD LIGAND BINDING PHYTOHORMONE BINDING PROTEIN TRZEATIN CYTOKININ PLANT PROTEIN
Ref.: CRYSTALLOGRAPHIC AND CD PROBING OF LIGAND-INDUCED CONFORMATIONAL CHANGES IN A PLANT PR-10 PROTEIN. J.STRUCT.BIOL. V. 193 55 2016
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 4RYV - ZEA C10 H13 N5 O C/C(=CCNc1....
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 2QIM - ZEA C10 H13 N5 O C/C(=CCNc1....
2 3E85 Kd = 4.2 uM BSU C13 H12 N2 O c1ccc(cc1)....
3 4MA6 - 28E C15 H14 O6 c1cc(c(cc1....
4 4RYV - ZEA C10 H13 N5 O C/C(=CCNc1....
50% Homology Family (18)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 2QIM - ZEA C10 H13 N5 O C/C(=CCNc1....
2 3E85 Kd = 4.2 uM BSU C13 H12 N2 O c1ccc(cc1)....
3 4JHG - ZEA C10 H13 N5 O C/C(=CCNc1....
4 4JHH - H35 C10 H9 N5 O c1cc(oc1)C....
5 4GY9 - ZIP C10 H13 N5 CC(=CCNc1c....
6 4MA6 - 28E C15 H14 O6 c1cc(c(cc1....
7 4A87 - NAR C15 H12 O5 c1cc(ccc1[....
8 4A8V - 2AN C16 H13 N O3 S c1ccc(cc1)....
9 4A86 - H35 C10 H9 N5 O c1cc(oc1)C....
10 4A85 - H35 C10 H9 N5 O c1cc(oc1)C....
11 4MNS - 2AX C15 H15 N O4 S C[C@H]1CS[....
12 4A83 - DXC C24 H40 O4 C[C@H](CCC....
13 4A80 - 2AN C16 H13 N O3 S c1ccc(cc1)....
14 1FM4 - DXC C24 H40 O4 C[C@H](CCC....
15 4A81 - DXC C24 H40 O4 C[C@H](CCC....
16 4A84 - DXC C24 H40 O4 C[C@H](CCC....
17 4RYV - ZEA C10 H13 N5 O C/C(=CCNc1....
18 5I8F - ML1 C13 H16 N2 O2 CC(=O)NCCc....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ZEA; Similar ligands found: 5
No: Ligand ECFP6 Tc MDL keys Tc
1 ZEA 1 1
2 ZEZ 1 1
3 ZIP 0.745455 0.808511
4 2KU 0.5 0.696429
5 EMU 0.462687 0.717391
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4RYV; Ligand: ZEA; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 4ryv.bio2) has 11 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 4RYV; Ligand: ZEA; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 4ryv.bio2) has 4 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 4RYV; Ligand: ZEA; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 4ryv.bio2) has 7 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 4RYV; Ligand: ZEA; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 4ryv.bio2) has 15 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 4RYV; Ligand: ZEA; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 4ryv.bio2) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 4RYV; Ligand: ZEA; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 4ryv.bio1) has 11 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 7; Query (leader) PDB : 4RYV; Ligand: ZEA; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 7) in the query (biounit: 4ryv.bio1) has 4 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 8; Query (leader) PDB : 4RYV; Ligand: ZEA; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 8) in the query (biounit: 4ryv.bio1) has 7 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 9; Query (leader) PDB : 4RYV; Ligand: ZEA; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 9) in the query (biounit: 4ryv.bio1) has 15 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 10; Query (leader) PDB : 4RYV; Ligand: ZEA; Similar sites found: 202
This union binding pocket(no: 10) in the query (biounit: 4ryv.bio1) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3IX8 TX3 0.005627 0.43416 None
2 2E5A LAQ 0.02393 0.40541 None
3 3PNA CMP 0.006947 0.40246 None
4 4NJS G08 0.0323 0.40237 None
5 5ML3 DL3 0.007779 0.43971 1.34228
6 4R38 RBF 0.01455 0.40575 1.42857
7 2YMZ LAT 0.00312 0.40802 1.53846
8 2D6M LBT 0.003528 0.44626 1.93548
9 3HKW IX6 0.03106 0.41872 1.93548
10 1M15 ADP 0.02367 0.41154 1.93548
11 1M15 ARG 0.02367 0.41154 1.93548
12 5VC5 96M 0.01826 0.41003 1.93548
13 5TV6 PML 0.005745 0.40342 1.93548
14 2ZHL NAG GAL GAL NAG 0.003686 0.41227 2.02703
15 4TW7 37K 0.000339 0.49476 2.34375
16 4DSU BZI 0.0001339 0.5093 2.58065
17 3QSB 743 0.0003517 0.46907 2.58065
18 1RE8 BD2 0.005406 0.45492 2.58065
19 2ZYI STE 0.007292 0.42705 2.58065
20 3ZJX BOG 0.0101 0.41345 2.58065
21 4K3P ACE GLN LEU ALA LEU PHE 0.0008085 0.40289 2.58065
22 4YLZ LAT NAG GAL 0.000344 0.43867 2.61438
23 1KGI T4A 0.0001465 0.50902 3.14961
24 3G5D 1N1 0.0005006 0.51696 3.22581
25 1TT8 PHB 0.0004953 0.48658 3.22581
26 4ORM FMN 0.01696 0.44112 3.22581
27 4ORM 2V6 0.01696 0.44112 3.22581
28 4ORM ORO 0.01696 0.44112 3.22581
29 1N07 FMN 0.0113 0.42689 3.22581
30 4UWJ MYA 0.04847 0.41598 3.22581
31 4UWJ 7L5 0.04847 0.41598 3.22581
32 1ZB6 GST 0.0256 0.40517 3.22581
33 1GQG DCD 0.01792 0.40463 3.22581
34 1ZB6 DIN 0.02664 0.40305 3.22581
35 4P5Z Q7M 0.003204 0.45958 3.87097
36 2C78 PUL 0.008079 0.45388 3.87097
37 2PNC CLU 0.001966 0.45292 3.87097
38 2YKL NLD 0.001889 0.43765 3.87097
39 5U98 1KX 0.01069 0.43561 3.87097
40 5UIU 8CG 0.009998 0.42586 3.87097
41 3EFS BTN 0.0002908 0.42419 3.87097
42 2QHV OC9 0.00497 0.42016 3.87097
43 5U98 VAL THR THR ASP ILE GLN VAL LYS VAL 0.01603 0.41673 3.87097
44 5T8U LPA 0.00607 0.41381 3.87097
45 2QHS OCA 0.006699 0.40935 3.87097
46 1PJS SAH 0.01494 0.4052 3.87097
47 2GQS C2R 0.004434 0.40286 3.87097
48 5MJA 7O3 0.01282 0.4007 3.87097
49 4Y24 TD2 0.009055 0.40323 3.8961
50 4ZU4 4TG 0.0007525 0.41249 4.05405
51 4QPW XYP XYP XYP 0.005226 0.40716 4.22535
52 3E9I XAH 0.0005679 0.48853 4.51613
53 5N87 N66 0.00105 0.48203 4.51613
54 1IF7 SBR 0.01254 0.45974 4.51613
55 4YZC STU 0.004123 0.4528 4.51613
56 3FW4 CAQ 0.00357 0.44241 4.51613
57 3IWJ NAD 0.003302 0.43308 4.51613
58 3CBC DBS 0.0001185 0.42929 4.51613
59 4USF 6UI 0.01114 0.41638 4.51613
60 1SBR VIB 0.00853 0.41366 4.51613
61 5LI1 ANP 0.01669 0.40453 4.51613
62 2X2M X2M 0.01717 0.40392 4.51613
63 5TO8 7FM 0.04364 0.40172 4.51613
64 1NYW DAU 0.01649 0.40134 4.51613
65 4L3L 5FI 0.002565 0.45562 5.16129
66 4F4P 0SB 0.02319 0.42984 5.16129
67 5LRT ADP 0.006728 0.42878 5.16129
68 4NFN 2KC 0.005961 0.41869 5.16129
69 4FE2 AIR 0.006623 0.40959 5.16129
70 5X8G S0N 0.04769 0.40865 5.16129
71 1U6R ADP 0.01156 0.40693 5.16129
72 2YAJ 4HP 0.01175 0.40028 5.16129
73 2AG4 LP3 0.000581 0.51776 5.80645
74 2AG4 OLA 0.0005218 0.51776 5.80645
75 5EW9 5VC 0.006785 0.47849 5.80645
76 3DLG GWE 0.004942 0.46899 5.80645
77 3MVH WFE 0.002086 0.46012 5.80645
78 1VJY 460 0.002723 0.45705 5.80645
79 1QY1 PRZ 0.001728 0.45265 5.80645
80 1CLU DBG 0.008599 0.44152 5.80645
81 1JJE BYS 0.003277 0.43723 5.80645
82 5A3T MMK 0.009759 0.42768 5.80645
83 3RZ3 U94 0.005019 0.42004 5.80645
84 5MW4 5JU 0.02326 0.41888 5.80645
85 2E0N SAH 0.008224 0.41404 5.80645
86 3TTZ 07N 0.006499 0.41241 5.80645
87 1KZN CBN 0.01151 0.40891 5.80645
88 2ZMF CMP 0.01286 0.40657 5.80645
89 1VRP ADP 0.01027 0.40527 5.80645
90 2HK5 1BM 0.01644 0.40317 5.80645
91 1T90 NAD 0.03202 0.40256 5.80645
92 4OPC FDA 0.001014 0.52473 6.45161
93 4OPC PGT 0.001164 0.52473 6.45161
94 5BYZ 4WE 0.000993 0.47781 6.45161
95 5XLY C2E 0.0002275 0.43903 6.45161
96 4P8K FAD 0.03587 0.4208 6.45161
97 4P8K 38C 0.03682 0.4208 6.45161
98 3WG3 A2G GAL NAG FUC 0.004527 0.41199 6.45161
99 1O9J NAD 0.0202 0.41164 6.45161
100 3NKS ACJ 0.01328 0.40205 6.45161
101 1A78 TDG 0.008319 0.41342 6.71642
102 5DQ8 FLF 0.0001128 0.5146 7.09677
103 2B4G FMN 0.01332 0.41691 7.09677
104 3W8X FAD 0.03325 0.41405 7.09677
105 1OIV GDP 0.01402 0.41295 7.09677
106 1HXD BTN 0.0005166 0.40816 7.09677
107 3RGA LSB 0.003761 0.42823 7.42049
108 4WVW SLT 0.01433 0.41542 7.63889
109 2RCU BUJ 0.006421 0.45773 7.74194
110 5H9P TD2 0.0003067 0.45378 7.74194
111 1PNF NDG NAG 0.008979 0.4133 7.74194
112 4GID 0GH 0.04372 0.41212 7.74194
113 5HCY 60D 0.03552 0.41003 7.74194
114 3GD9 GLC BGC BGC BGC 0.007919 0.40837 7.74194
115 1NCQ W11 0.0009822 0.40783 7.74194
116 5FUI APY 0.00009301 0.5298 8.33333
117 5BVE 4VG 0.01315 0.44456 8.3871
118 3A5Y KAA 0.003606 0.4422 8.3871
119 4WOE ADP 0.003469 0.43737 8.3871
120 1REQ DCA 0.03323 0.41242 8.3871
121 4QTB 38Z 0.02338 0.40593 8.3871
122 5E89 TD2 0.001219 0.41558 8.63309
123 5DEY 59T 0.001466 0.49031 9.03226
124 1OUK 084 0.006589 0.47921 9.03226
125 4CQE CQE 0.006623 0.44332 9.03226
126 1F76 FMN 0.006292 0.43175 9.03226
127 4LOO SB4 0.004459 0.42682 9.03226
128 4XV1 904 0.01163 0.42624 9.03226
129 3JU6 ANP 0.007748 0.41572 9.03226
130 3B6R ADP 0.008408 0.41155 9.03226
131 3A16 PXO 0.02394 0.40232 9.03226
132 4L9I 8PR 0.01377 0.40129 9.03226
133 3G08 FEE 0.0005646 0.51417 9.67742
134 3KRR DQX 0.001354 0.49947 9.67742
135 2Y6Q I7T 0.005874 0.4557 9.67742
136 3OIX FMN 0.006306 0.42859 9.67742
137 5L2J 70E 0.03065 0.42818 9.67742
138 5L2J 6UL 0.02918 0.42818 9.67742
139 4PFC 2QX 0.01036 0.42096 9.67742
140 5H9Y BGC BGC BGC BGC 0.005975 0.41645 9.67742
141 4B7P 9UN 0.03184 0.41506 9.67742
142 3SCM LGN 0.04377 0.41346 9.67742
143 5ECP MET 0.03391 0.41023 9.67742
144 5ECP JAA 0.0368 0.40835 9.67742
145 5H2U 1N1 0.002986 0.40132 9.67742
146 1NB9 RBF 0.01998 0.41949 10.2041
147 1NB9 ADP 0.01998 0.41949 10.2041
148 5W4W 9WG 0.011 0.42503 10.3226
149 4KBA 1QM 0.004061 0.42437 10.3226
150 3LXK MI1 0.01152 0.42007 10.3226
151 5JKG 6LF 0.01985 0.41865 10.3226
152 4N70 2HX 0.03065 0.41674 10.3226
153 5HES 032 0.00952 0.41648 10.3226
154 1M2K APR 0.01713 0.41275 10.3226
155 4HN1 TYD 0.01228 0.40158 10.3226
156 1V3S ATP 0.004569 0.43023 10.3448
157 3C6K SPD 0.03216 0.40773 10.4987
158 3C6K MTA 0.03216 0.40773 10.4987
159 5TVF CGQ 0.01224 0.40136 10.5882
160 1KOR ANP 0.01243 0.45947 10.9677
161 1KOR SIN 0.01219 0.45947 10.9677
162 1KOR ARG 0.01219 0.45947 10.9677
163 5KJW 53C 0.000179 0.44213 10.9677
164 3SAO NKN 0.006574 0.40974 10.9677
165 2QZ3 XYP XYP XYP 0.01423 0.40793 10.9677
166 3SAO DBH 0.0002704 0.40607 10.9677
167 3W9K MYR 0.01035 0.40513 11.5108
168 4IGH ORO 0.01936 0.43858 11.6129
169 4IGH FMN 0.01936 0.43858 11.6129
170 4IGH 1EA 0.01936 0.43858 11.6129
171 4FFG 0U8 0.003868 0.43105 11.6129
172 5XDT ZI7 0.004066 0.44269 12.2581
173 2XIQ MLC 0.008786 0.42998 12.2581
174 2XG5 EC2 0.01013 0.4079 12.2581
175 2XG5 EC5 0.01013 0.4079 12.2581
176 5UKL SIX 0.02301 0.40497 12.2581
177 2JLD AG1 0.0003274 0.50509 12.9032
178 5AWM ANP 0.009379 0.40251 12.9032
179 3FQ8 PMP 0.02228 0.40146 12.9032
180 1LSH PLD 0.0003837 0.49708 13.5484
181 2Y6O 1N1 0.01862 0.4022 13.5484
182 5DG2 GAL GLC 0.0029 0.43119 14.0741
183 1QKQ MAN 0.00008832 0.50748 14.0845
184 4WNK 453 0.005451 0.43914 14.1935
185 4YVN EBS 0.003859 0.43437 14.1935
186 2WOX NDP 0.01416 0.42413 14.1935
187 2WME NAP 0.00616 0.42205 14.1935
188 4L4V 1VY 0.01045 0.40704 15.4839
189 2CJU PHX 0.01383 0.40707 15.7025
190 5LYH 7B8 0.005205 0.44278 16.129
191 4EMV 0R9 0.004212 0.43002 16.129
192 4L77 CNL 0.008253 0.40958 17.4194
193 3RHJ NAP 0.008373 0.43912 18.0645
194 5HWV MBN 0.001104 0.4283 18.4615
195 3OV6 MK0 0.00942 0.42845 18.7097
196 2GJ5 VD3 0.02008 0.41839 18.7097
197 2XMY CDK 0.008956 0.45563 20
198 1QD1 FON 0.00204 0.45443 20.6452
199 5JCA FAD 0.03883 0.40882 22.5806
200 5F3I 5UJ 0.01461 0.43858 25.8065
201 1I7M CG 0.01057 0.40009 26.8657
202 4PSB GA3 0.02945 0.40664 41.2903
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