Receptor
PDB id Resolution Class Description Source Keywords
4R38 1.6 Å EC: 2.7.13.3 LOV DOMAIN FROM ERYTHROBACTER LITORALIS EL346 BLUE-LIGHT ACT HISTIDINE KINASE ERYTHROBACTER LITORALIS HTCC2594 RIBOFLAVIN LIGHT-ACTIVATED LOV DOMAIN PHOTORECEPTOR SENSTRANSDUCTION SIGNAL TRANSDUCTION SIGNALING PROTEIN
Ref.: FULL-LENGTH STRUCTURE OF A MONOMERIC HISTIDINE KINA REVEALS BASIS FOR SENSORY REGULATION. PROC.NATL.ACAD.SCI.USA V. 111 17839 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
RBF A:201;
D:201;
C:201;
B:201;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
376.364 C17 H20 N4 O6 Cc1cc...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4R38 1.6 Å EC: 2.7.13.3 LOV DOMAIN FROM ERYTHROBACTER LITORALIS EL346 BLUE-LIGHT ACT HISTIDINE KINASE ERYTHROBACTER LITORALIS HTCC2594 RIBOFLAVIN LIGHT-ACTIVATED LOV DOMAIN PHOTORECEPTOR SENSTRANSDUCTION SIGNAL TRANSDUCTION SIGNALING PROTEIN
Ref.: FULL-LENGTH STRUCTURE OF A MONOMERIC HISTIDINE KINA REVEALS BASIS FOR SENSORY REGULATION. PROC.NATL.ACAD.SCI.USA V. 111 17839 2014
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 18 families.
1 4R38 - RBF C17 H20 N4 O6 Cc1cc2c(cc....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 18 families.
1 4R38 - RBF C17 H20 N4 O6 Cc1cc2c(cc....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 16 families.
1 4R38 - RBF C17 H20 N4 O6 Cc1cc2c(cc....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: RBF; Similar ligands found: 15
No: Ligand ECFP6 Tc MDL keys Tc
1 RBF 1 1
2 FMN 0.75641 0.876712
3 RS3 0.74026 0.942029
4 DLZ 0.546667 0.885714
5 1VY 0.525641 0.871429
6 C3F 0.523256 0.816901
7 LFN 0.513889 0.712121
8 CF4 0.511364 0.805556
9 FAD 0.460938 0.790123
10 FAS 0.460938 0.790123
11 FAE 0.457364 0.780488
12 RLP 0.438202 0.833333
13 DAL FAD PER 0.42446 0.771084
14 FO1 0.423913 0.871429
15 HDF 0.423913 0.871429
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4R38; Ligand: RBF; Similar sites found: 208
This union binding pocket(no: 1) in the query (biounit: 4r38.bio1) has 22 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1UO5 PIH 0.001817 0.46991 None
2 4Z28 BTN 0.001975 0.4479 None
3 1MDC PLM 0.0008313 0.44187 None
4 4GGZ BTN 0.002385 0.4391 None
5 3T2W BTN 0.004135 0.43233 None
6 5F6U 5VK 0.005688 0.43128 None
7 1GZW GAL BGC 0.009357 0.42644 None
8 1GEG GLC 0.01341 0.42117 None
9 2YIP YIO 0.01934 0.41538 None
10 4WG0 CHD 0.01096 0.41187 None
11 2E1A MSE 0.01376 0.41113 None
12 4E2J MOF 0.003432 0.40091 None
13 2AGC DAO 0.006631 0.42696 1.42857
14 2HFN FMN 0.003669 0.41788 1.42857
15 2WQN ADP 0.006891 0.41727 1.42857
16 1SR7 MOF 0.007253 0.41307 1.42857
17 4RYV ZEA 0.01455 0.40575 1.42857
18 4I9A NCN 0.007665 0.40372 1.42857
19 4YMJ 4EJ 0.03067 0.4002 1.42857
20 1W6O LAT 0.01061 0.42165 1.49254
21 1W6P NDG GAL 0.009741 0.40929 1.49254
22 2AIB ERG 0.002647 0.42534 2.04082
23 5D9G GLU ASN LEU TYR PHE GLN 0.00439 0.43589 2.14286
24 3KRR DQX 0.01304 0.42526 2.14286
25 2YAK OSV 0.005093 0.41727 2.14286
26 5HV0 AKG 0.001964 0.40242 2.14286
27 1OJJ GLC GAL 0.004162 0.43704 2.85714
28 2ZMF CMP 0.001684 0.42879 2.85714
29 3KU0 ADE 0.01325 0.42588 2.85714
30 5C5T AKG 0.01033 0.41736 2.85714
31 4H2W AMP 0.008326 0.40568 2.85714
32 4B2Z P5S 0.01642 0.40373 2.85714
33 3MF2 AMP 0.00788 0.40001 2.85714
34 5DG2 GAL GLC 0.005983 0.40147 2.96296
35 2G30 ALA ALA PHE 0.000000699 0.65194 3.57143
36 5A5W GUO 0.003576 0.43607 3.57143
37 4Z3E GAL NGA GLA BGC GAL 0.00974 0.42198 3.57143
38 3OQJ 3CX 0.008557 0.41699 3.57143
39 3R9V DXC 0.01043 0.41632 3.57143
40 4WVW SLT 0.01085 0.41581 3.57143
41 1W62 PYC 0.01415 0.41499 3.57143
42 4Y8D 49J 0.0209 0.40626 3.57143
43 5DQ8 FLF 0.01143 0.40302 3.57143
44 3EWC MCF 0.008073 0.40274 3.57143
45 1G0N PHH 0.0209 0.40266 3.57143
46 5E89 TD2 0.001946 0.43422 3.59712
47 2A4W BLM 0.006908 0.41006 3.62319
48 2BYC FMN 0.001623 0.447 3.64964
49 4UY1 TJM 0.008305 0.41342 3.81679
50 3A6T 8OG 0.00421 0.41908 3.87597
51 1OUK 084 0.009709 0.44803 4.28571
52 4YRD 3IT 0.005604 0.43043 4.28571
53 4CS4 AXZ 0.009185 0.42104 4.28571
54 1U3R 338 0.00446 0.41413 4.28571
55 2Y6Q I7T 0.01762 0.41036 4.28571
56 1O5R FR9 0.008451 0.41011 4.28571
57 4LOO SB4 0.002272 0.40845 4.28571
58 4O9S 2RY 0.001543 0.40689 4.28571
59 4A3R CIT 0.009614 0.40652 4.28571
60 4CS4 ANP 0.0143 0.40647 4.28571
61 1RYD GLC 0.02377 0.40602 4.28571
62 5MX4 HPA 0.02741 0.4024 4.28571
63 3PDT ADP 0.01233 0.40151 4.28571
64 1IIU RTL 0.00437 0.40077 4.28571
65 4WOE ADP 0.00004677 0.54748 5
66 4BG4 ADP 0.00009669 0.48759 5
67 3PUR 2HG 0.003029 0.45232 5
68 4BVA T3 0.004555 0.43021 5
69 3H7J PPY 0.003958 0.42437 5
70 3GLC R5P 0.006073 0.41987 5
71 1GT4 UNA 0.0008388 0.41918 5
72 3VQ2 LP4 LP5 MYR DAO 0.01496 0.40941 5
73 4XBT 3ZQ 0.006135 0.408 5
74 1VHW ADN 0.01349 0.40736 5
75 3OV6 MK0 0.009479 0.40663 5
76 4XBT FLC 0.006791 0.40605 5
77 2PP3 LGT 0.01226 0.40162 5
78 2TPI ILE VAL 0.0073 0.40466 5.17241
79 1M15 ADP 0.0004783 0.46844 5.71429
80 1M15 ARG 0.0004783 0.46844 5.71429
81 3B6R ADP 0.000389 0.46578 5.71429
82 5EW9 5VC 0.02033 0.43174 5.71429
83 3G5D 1N1 0.007566 0.43162 5.71429
84 3SHZ 5CO 0.009747 0.41424 5.71429
85 5IR4 ZPE 0.01266 0.41277 5.71429
86 3JQ3 ADP 0.0006014 0.40666 5.71429
87 5H2U 1N1 0.006739 0.4062 5.71429
88 4ZSI GLP 0.008685 0.40485 5.71429
89 2J3M PRI 0.007189 0.40336 5.71429
90 3W68 VIV 0.005484 0.40323 5.71429
91 4DQ2 BTX 0.01106 0.40236 5.71429
92 5V1B 8UY 0.02523 0.40205 5.71429
93 3ZH4 FLC 0.0188 0.4016 5.71429
94 1Y0G 8PP 0.02262 0.40107 5.71429
95 1ZHX HC3 0.009922 0.40033 5.71429
96 1L0I PSR 0.02189 0.40267 6.41026
97 1T0S BML 0.002236 0.45618 6.42857
98 3NZ1 3NY 0.003865 0.43897 6.42857
99 2QHV OC9 0.003868 0.43863 6.42857
100 5MBC FMN 0.001569 0.43845 6.42857
101 2QHS OCA 0.005339 0.42695 6.42857
102 3SXF BK5 0.005071 0.42247 6.42857
103 2OVW CBI 0.01277 0.41728 6.42857
104 5AWM ANP 0.01152 0.41071 6.42857
105 4I94 ANP 0.002081 0.41031 6.42857
106 2XVD AS6 0.007954 0.40736 6.42857
107 1Q11 TYE 0.02034 0.40687 6.42857
108 3A5Z KAA 0.01141 0.40177 6.42857
109 4WN5 MVC 0.002697 0.40622 6.95652
110 1WUB OTP 0.002527 0.44506 7.14286
111 5JSP DQY 0.004642 0.44243 7.14286
112 5U9J GER 0.005833 0.43472 7.14286
113 1LRI CLR 0.001799 0.42929 7.14286
114 3IES M24 0.004571 0.42569 7.14286
115 1R5L VIV 0.006381 0.40717 7.14286
116 1H8S AIC 0.01891 0.40421 7.14286
117 5TCI MLI 0.03537 0.40199 7.14286
118 3EXS 5RP 0.01744 0.40192 7.14286
119 2IYG FMN 0.001034 0.45627 7.25806
120 1YRX FMN 0.001663 0.44178 7.43802
121 4JNJ BTN 0.004175 0.4233 7.82609
122 4MGA 27L 0.005923 0.44134 7.85714
123 1XZ3 ICF 0.01394 0.43516 7.85714
124 1ERB ETR 0.001787 0.43435 7.85714
125 1PS9 FAD 0.0189 0.40469 7.85714
126 3TDV GDP 0.008937 0.40076 7.85714
127 5IF4 6AK 0.01138 0.40051 7.85714
128 2C9O ADP 0.006361 0.40049 7.85714
129 4TUZ 36J 0.01564 0.40035 7.85714
130 5KJW 53C 0.0006634 0.48747 8.57143
131 1DZK PRZ 0.0007926 0.45183 8.57143
132 4GJY OGA 0.01247 0.41997 8.57143
133 5FXD H7Y 0.004162 0.4193 8.57143
134 2ZV2 609 0.01081 0.41205 8.57143
135 2B3B BGC 0.01714 0.40635 8.57143
136 1NW4 IMH 0.02236 0.40056 8.57143
137 4F4P 0SB 0.0379 0.40026 8.57143
138 4XCB AKG 0.004622 0.43989 9.28571
139 1U6R ADP 0.0004319 0.43823 9.28571
140 4B0T ADP 0.002208 0.42714 9.28571
141 1QY1 PRZ 0.001385 0.42234 9.28571
142 4OPC PGT 0.03917 0.41948 9.28571
143 4OPC FDA 0.03469 0.41948 9.28571
144 4RQL SNE 0.01085 0.4163 9.28571
145 3L9R L9R 0.009105 0.41439 9.28571
146 3L9R L9Q 0.007857 0.41393 9.28571
147 2RKV ZBA 0.01282 0.40762 9.28571
148 3GD9 GLC BGC BGC BGC 0.0008733 0.40713 9.28571
149 4O4K 2PK 0.006418 0.40548 9.28571
150 1I06 TZL 0.02698 0.40054 9.28571
151 1EPB REA 0.001084 0.44569 10.7143
152 4REI 3MV 0.01278 0.41872 10.7143
153 3E9I XAH 0.006872 0.41152 10.7143
154 1K97 CIR 0.01424 0.40656 10.7143
155 1K97 ASP 0.01424 0.40656 10.7143
156 5TH5 MET 0.02262 0.4045 10.7143
157 1KJ1 MAN 0.02359 0.40243 11.0092
158 1ZOY UQ1 0.003714 0.45057 11.4286
159 3FUR Z12 0.006588 0.42865 11.4286
160 3KMZ EQO 0.004234 0.41646 11.4286
161 1ODJ GMP 0.006678 0.41386 11.4286
162 5MRH Q9Z 0.001689 0.45653 12.1429
163 3I27 SID 0.005639 0.43547 12.1429
164 2QES ADE 0.02459 0.4103 12.1429
165 3ZJX BOG 0.006847 0.43485 12.8571
166 4KBA 1QM 0.0008012 0.47263 13.5714
167 4L6H HCS 0.009842 0.4236 13.5714
168 3FW4 CAQ 0.002957 0.42165 13.5714
169 1H2M OGA 0.02235 0.40368 13.5714
170 2Y88 2ER 0.01519 0.40322 13.5714
171 4B7E OGA 0.02498 0.40316 13.5714
172 1H2K OGA 0.02284 0.40301 13.5714
173 2ADA HPR 0.004259 0.40277 13.5714
174 2WA4 069 0.01429 0.40223 13.5714
175 1M5W DXP 0.005214 0.43721 14.2857
176 3QRC SCR 0.004047 0.43378 15
177 4ITH RCM 0.004603 0.40645 15
178 3KV5 OGA 0.006414 0.43165 15.7143
179 5MWE TCE 0.01629 0.41184 15.7143
180 3GKJ HC3 0.003961 0.40921 15.7143
181 4JH6 FCN 0.008927 0.42052 16.6667
182 1YKD CMP 0.002543 0.40877 17.1429
183 3RGA LSB 0.01021 0.40166 17.1429
184 1GQG DCD 0.005338 0.40727 18.5714
185 4XT2 43L 0.000346 0.44151 18.8034
186 2R0D 4IP 0.01672 0.41126 19.2857
187 1T36 ADP 0.005882 0.41171 20.7143
188 2Q8H TF4 0.03251 0.40881 20.7143
189 3KP6 SAL 0.01936 0.42446 22.1429
190 3W54 RNB 0.003753 0.42544 22.8571
191 2XN5 FUN 0.01804 0.4012 22.8571
192 3G08 FEE 0.01553 0.41679 23.2323
193 3FW9 SLX 0.002404 0.41315 23.5714
194 4MNS 2AX 0.01277 0.41693 25
195 5U98 1KX 0.03371 0.40337 30.303
196 5L2J 6UL 0.01173 0.42877 30.6122
197 5SVV FMN 0.0000000000003579 0.83393 40.146
198 4WUJ FMN 0.0000000000001398 0.86412 44.2857
199 3IS2 FAD 0.0000000000005869 0.85196 44.2857
200 2WKQ FMN 0.0000000000007285 0.83315 44.2857
201 5EFW FMN 0.000000000002591 0.80936 44.2857
202 5DJU FMN 0.000000000004072 0.78928 44.2857
203 5DJT FMN 0.0000000000019 0.78892 44.2857
204 3D72 FAD 0.0000000000008833 0.66259 44.2857
205 2V0U FMN 0.000000000002083 0.81345 45
206 3P7N FMN 0.00000000002599 0.76612 45.7143
207 4HIA FMN 0.000000000003567 0.83517 47.8571
208 5DKK FMN 0.00000000001488 0.77658 47.8571
Pocket No.: 2; Query (leader) PDB : 4R38; Ligand: RBF; Similar sites found: 60
This union binding pocket(no: 2) in the query (biounit: 4r38.bio6) has 22 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1BHX ASP PHE GLU GLU ILE 0.00458 0.43018 None
2 4MA6 28E 0.0003714 0.41061 None
3 4MMP SLB 0.001573 0.40596 None
4 4HBM 0Y7 0.00909 0.40395 None
5 5C3R AKG 0.01057 0.40099 None
6 5C3R HMU 0.01057 0.40099 None
7 5UFS 1TA 0.003596 0.40074 None
8 1TUK PGM 0.01853 0.40063 None
9 5TFZ 7BC 0.01002 0.41801 1.42857
10 2YY7 NAD 0.01231 0.40281 1.42857
11 4Y2B EPK 0.01287 0.4171 2.85714
12 1W2D ADP 0.01561 0.40427 2.85714
13 4LBP 1WG 0.02067 0.40228 3
14 3LXI CAM 0.01555 0.41519 3.57143
15 4LED XXR 0.01046 0.41221 3.57143
16 2B9I ADP 0.005033 0.41181 3.57143
17 3KV4 OGA 0.01949 0.40874 3.57143
18 2B9J ADP 0.009251 0.4036 3.57143
19 4U0W 16G 0.007842 0.40328 3.57143
20 3PUA OGA 0.0244 0.4046 4.28571
21 5IH9 6BF 0.01419 0.40348 4.28571
22 1X8X TYR 0.01772 0.40157 4.28571
23 2PT9 2MH 0.01664 0.40035 4.98442
24 3N9O OGA 0.002672 0.45404 5
25 5CKS GAL 0.02152 0.41255 5
26 4YLL 4E3 0.006371 0.40397 5
27 4I3G BGC 0.02065 0.4023 5
28 4N14 WR7 0.005438 0.42384 5.71429
29 5FLJ QUE 0.004745 0.40946 5.71429
30 2F6U CIT 0.02293 0.40419 5.71429
31 2XMY CDK 0.0381 0.40327 5.71429
32 4NS0 PIO 0.01415 0.40703 6.01504
33 4TW7 37K 0.00806 0.40427 6.25
34 2VD9 IN5 0.006765 0.40976 6.42857
35 1X0P FAD 0.002226 0.40485 6.42857
36 4FFG LBS 0.018 0.40295 6.42857
37 2VD9 EPC 0.008132 0.40258 6.42857
38 4FFG 0U8 0.02558 0.40174 6.42857
39 5H9Q TD2 0.004509 0.42288 7.14286
40 5LUN OGA 0.01401 0.40656 7.14286
41 4OCT AKG 0.01574 0.40409 7.14286
42 4MG8 27J 0.006009 0.41598 7.85714
43 5EVY SAL 0.01826 0.41087 7.85714
44 4TV1 36M 0.01892 0.40849 7.85714
45 2QE4 JJ3 0.02268 0.40749 7.85714
46 4D4U FUC 0.01783 0.40359 7.85714
47 1QFT HSM 0.01054 0.40104 7.85714
48 2GC0 PAN 0.004043 0.41601 8.57143
49 3C0G 3AM 0.01367 0.40314 8.57143
50 2BCG GER 0.009546 0.41907 9.28571
51 3WV6 GAL BGC 0.007134 0.42335 10
52 3BRN SRO 0.01958 0.4086 10.7143
53 3G9E RO7 0.005229 0.42188 11.4286
54 4IPN 1FT 0.01431 0.40219 12.1429
55 5AX9 4KT 0.007227 0.40485 13.5714
56 2IF8 ADP 0.01996 0.4073 14.2857
57 3E7S AT2 0.02681 0.40655 15
58 2CKM AA7 0.02341 0.40037 17.1429
59 3ZGJ RMN 0.01352 0.41151 18.5714
60 4RW3 TDA 0.04916 0.40116 25
Pocket No.: 3; Query (leader) PDB : 4R38; Ligand: RBF; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 4r38.bio6) has 21 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 4R38; Ligand: RBF; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 4r38.bio5) has 22 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 4R38; Ligand: RBF; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 4r38.bio5) has 22 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 4R38; Ligand: RBF; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 4r38.bio2) has 22 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 7; Query (leader) PDB : 4R38; Ligand: RBF; Similar sites found: 18
This union binding pocket(no: 7) in the query (biounit: 4r38.bio4) has 21 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5IXH OTP 0.01749 0.40918 None
2 1SWG BTN 0.01164 0.40818 None
3 5LN8 GAL 0.01877 0.40721 None
4 3RDO BTN 0.003104 0.40235 None
5 2X32 OTP 0.03114 0.40059 2.14286
6 3EW2 BTN 0.001455 0.40395 3.7037
7 3LHS SF8 0.0233 0.4021 4.28571
8 1AUA BOG 0.02452 0.40097 4.28571
9 2TPS TPS 0.009561 0.4042 5.71429
10 5EOB 5QQ 0.02852 0.4062 6.42857
11 5N17 8FK 0.02426 0.40272 6.52174
12 2B3B GLC 0.01943 0.40187 8.57143
13 1TDF FAD 0.03313 0.40008 10
14 3RGZ BLD 0.007213 0.41044 10.7143
15 4W9F 3JU 0.02525 0.40031 10.7143
16 4HEE 14R 0.00372 0.40669 11.4286
17 1FM9 570 0.01247 0.4044 11.4286
18 5AIG VPR 0.006668 0.42497 14.4
Pocket No.: 8; Query (leader) PDB : 4R38; Ligand: RBF; Similar sites found: 23
This union binding pocket(no: 8) in the query (biounit: 4r38.bio3) has 22 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5FQ0 FLC 0.008374 0.4279 1.75439
2 4IDT T28 0.005975 0.4122 2.85714
3 3AVR OGA 0.02976 0.40114 2.85714
4 5M0T AKG 0.02802 0.40087 3.57143
5 2Z77 HE7 0.006416 0.40034 3.59712
6 1Z6K OAA 0.01353 0.41806 4.28571
7 2CHG ANP 0.003131 0.41541 4.28571
8 1S14 NOV 0.0264 0.40103 4.28571
9 4NFN 2KC 0.008809 0.40457 5
10 3LQV ADE 0.01447 0.41583 6.08696
11 4A38 BZS 0.02619 0.40031 6.42857
12 2Y7P SAL 0.0221 0.40502 7.14286
13 1DZT TPE 0.02384 0.40489 7.14286
14 3UU7 2OH 0.02196 0.40679 7.85714
15 2AQJ TRP 0.03487 0.4033 7.85714
16 2QZO KN1 0.004766 0.40154 7.85714
17 3VV5 SLZ 0.01306 0.40805 8.57143
18 4Q3S X7A 0.01574 0.40022 8.57143
19 4ZV1 ARG 0.01291 0.41251 10.7143
20 5HCN DAO 0.02353 0.40361 11.4286
21 1OYF MHN 0.03071 0.40103 12.3967
22 3P3N AKG 0.02301 0.40315 13.5714
23 3TKI S25 0.01549 0.41535 14.2857
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