Receptor
PDB id Resolution Class Description Source Keywords
4Q5M 1.8 Å EC: 3.4.23.16 D30N TETHERED HIV-1 PROTEASE DIMER/SAQUINAVIR COMPLEX HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Ref.: STRUCTURAL BASIS OF WHY NELFINAVIR-RESISTANT D30N M HIV-1 PROTEASE REMAINS SUSCEPTIBLE TO SAQUINAVIR. CHEM.BIOL.DRUG DES. 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ROC A:1101;
Valid;
Atoms found MORE than expected: % Diff = 2;
submit data
670.841 C38 H50 N6 O5 CC(C)...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4Q5M 1.8 Å EC: 3.4.23.16 D30N TETHERED HIV-1 PROTEASE DIMER/SAQUINAVIR COMPLEX HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Ref.: STRUCTURAL BASIS OF WHY NELFINAVIR-RESISTANT D30N M HIV-1 PROTEASE REMAINS SUSCEPTIBLE TO SAQUINAVIR. CHEM.BIOL.DRUG DES. 2014
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 27 families.
1 3DOX - SER GLN ASN TYR n/a n/a
2 4Q5M - ROC C38 H50 N6 O5 CC(C)(C)NC....
70% Homology Family (17)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 21 families.
1 2O40 - 2NC C35 H68 N11 O8 CCCC[C@@H]....
2 3NXN - KVS C36 H68 N10 O10 [H]/N=C(N)....
3 3IAW Kd = 1.57 uM 2NC C35 H68 N11 O8 CCCC[C@@H]....
4 3NXE - 2NC C35 H68 N11 O8 CCCC[C@@H]....
5 3FSM Kd = 100 nM 2NC C35 H68 N11 O8 CCCC[C@@H]....
6 4EP2 Kd = 4.43 uM ALA GLU THR PHE TYR VAL ASP GLY n/a n/a
7 4EQ0 - ALA THR ILE MET MET GLN ARG GLY n/a n/a
8 4EP3 - LYS ALA ARG VAL LEU ALA GLU ALA MET n/a n/a
9 3KA2 Kd = 0.24 uM 2NC C35 H68 N11 O8 CCCC[C@@H]....
10 3HLO Kd = 0.61 uM 2NC C35 H68 N11 O8 CCCC[C@@H]....
11 4EPJ - ALA THR ILE MET MET GLN ARG GLY n/a n/a
12 1HVC - A79 C44 H58 N8 O6 CC(C)[C@@H....
13 2WHH - PPN C9 H10 N2 O4 c1cc(ccc1C....
14 3N3I - ROC C38 H50 N6 O5 CC(C)(C)NC....
15 4EQJ Kd = 2.52 uM ALA GLU THR PHE TYR VAL ASP GLY n/a n/a
16 3DOX - SER GLN ASN TYR n/a n/a
17 4Q5M - ROC C38 H50 N6 O5 CC(C)(C)NC....
50% Homology Family (597)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 21 families.
1 4HEG Ki = 1.2 nM G52 C30 H40 N2 O9 S CC(C)C[N@@....
2 1MER Ki = 10 nM DMQ C33 H36 N4 O3 c1ccc(cc1)....
3 6B3H - CN4 C30 H32 F3 N3 O3 S c1cc(c(c(c....
4 4HLA - 017 C27 H37 N3 O7 S CC(C)C[N@@....
5 3TKW - 017 C27 H37 N3 O7 S CC(C)C[N@@....
6 4COE Ki = 65 nM M17 C44 H59 N5 O6 CC(C)[C@@H....
7 1HVR Ki = 0.31 nM XK2 C41 H38 N2 O3 c1ccc(cc1)....
8 2BPV Ki = 21.2 nM 1IN C35 H51 N5 O5 C[C@H]1CC[....
9 1G35 Ki = 7.3 nM AHF C35 H40 N2 O9 S COC(c1ccc(....
10 2QI5 Ki = 0.014 nM MZ7 C29 H40 N4 O5 S2 CCCCC[N@@]....
11 6IXD Ki = 0.16 nM B0F C45 H56 N6 O8 S2 Cc1cc(cc(c....
12 4K4R - 3TL C50 H64 N6 O10 C[C@@H](C(....
13 6MCS - JDV C33 H41 F N4 O7 S2 CC(C)CN(C[....
14 3CKT Ki = 0.48 uM YDP C28 H37 N5 O6 S2 CC(=CCN([C....
15 6OXO - NJM C28 H38 N2 O8 S CC(C)CN(C[....
16 2AVS Ki = 27 nM MK1 C36 H47 N5 O4 CC(C)(C)NC....
17 2IDW Ki = 1.3 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
18 2I4V Ki = 6.3 pM DJR C28 H38 N2 O8 S CC(C)C[N@@....
19 1NPV ic50 = 5.7 nM L27 C35 H37 N3 O6 c1ccc(cc1)....
20 1HIV Ki < 1 nM 1ZK C45 H62 N7 O7 CC[C@H](C)....
21 4I8Z Ki = 8.9 pM G08 C28 H37 N3 O8 S CC(C)CN(C[....
22 2F3K Kd = 0.95 nM RO1 C37 H53 N5 O7 S CC(C)(C)NC....
23 4ZIP Ki = 0.21 nM G64 C37 H46 N4 O7 S Cc1cc(cc(c....
24 3R4B - 74T C38 H53 N5 O7 S2 CC(C)C[N@@....
25 1AJV Ki = 19.1 nM NMB C32 H34 N2 O6 S c1ccc(cc1)....
26 4U7V Ki = 3.2 uM 3EN C28 H36 N4 O4 S CC(C)[C@@H....
27 6DJ7 Ki = 1.9 nM G10 C27 H35 F2 N3 O7 S CC(C)CN(C[....
28 1GNM Ki = 560 nM U0E C28 H52 N8 O6 CC(C)[C@H]....
29 3KDB Kd = 0.14 nM 006 C35 H41 N3 O6 S Cc1cccc(c1....
30 6DH8 Ki = 146.2 pM A60 C29 H41 N3 O7 S CCC(CC)C[N....
31 1B6K Ki = 1.8 nM PI5 C37 H53 N5 O7 CC[C@H](C)....
32 4DQF - 017 C27 H37 N3 O7 S CC(C)C[N@@....
33 1QBT Ki = 0.024 nM 146 C49 H44 N8 O5 c1ccc(cc1)....
34 5COO - 52Z C30 H42 N2 O10 S CC(C)CN(C[....
35 6PJF Ki = 0.235 nM OP7 C34 H45 N3 O8 COC(=O)N[C....
36 4HDF Ki = 3.2 nM G52 C30 H40 N2 O9 S CC(C)C[N@@....
37 4FM6 - TYR ASP GLN ILE ILE ILE n/a n/a
38 6E9A Ki = 0.0012 nM J0S C28 H37 N3 O8 S CC(C)CN(C[....
39 4FLG - GLN ILE ILE n/a n/a
40 1W5X Ki = 4 nM BE5 C38 H36 F4 N2 O8 c1ccc2c(c1....
41 6CDJ Ki = 2 pM GR8 C34 H42 F2 N4 O7 S2 CC(C)CN(C[....
42 4CPU Ki = 29.5 nM V78 C40 H55 N5 O6 S CC(C)[C@H]....
43 3ZPU Ki = 4.2 nM M8B C37 H52 Br N5 O6 CC(C)(C)[C....
44 1K6P Kd = 44 nM XN3 C38 H48 N4 O6 CC(C)(C)NC....
45 6OXR - NJA C29 H40 N2 O8 S C[C@@H](c1....
46 1Z1R Ki = 0.6 nM HBH C29 H40 N4 O7 S CC(C)CC[N@....
47 3OK9 Ki = 5.9 pM G52 C30 H40 N2 O9 S CC(C)C[N@@....
48 2IEO Ki = 3.2 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
49 3B7V - ASN LEU LNT GLN ILE n/a n/a
50 1SDU Ki = 86 pM MK1 C36 H47 N5 O4 CC(C)(C)NC....
51 1B6J Ki = 12 nM ASN RTY PRO ILE VAL NH2 n/a n/a
52 4DQC - 017 C27 H37 N3 O7 S CC(C)C[N@@....
53 3MXE Ki = 0.097 nM K54 C32 H33 F3 N4 O6 S2 CC(C)C[N@@....
54 2HB3 Ki = 0.0045 nM GRL C29 H40 N2 O7 S CC(C)CN(C[....
55 7UPJ Ki = 3.2 nM INU C27 H29 N O5 S c1ccc(cc1)....
56 1EBZ Ki = 0.4 nM BEC C35 H43 N3 O8 CC(C)[C@@H....
57 6DH5 - A60 C29 H41 N3 O7 S CCC(CC)C[N....
58 1HBV Ki = 430 nM GAN C32 H51 N5 O5 CC(C)[C@@H....
59 1D4I Ki = 1.4 nM BEG C38 H40 N2 O7 c1ccc(cc1)....
60 5JFU Ki = 8.5 nM 6KQ C35 H46 N2 O8 S COc1ccc(cc....
61 4GZF ic50 = 4.4 nM ILO VAL DC0 GLU ALA NLE n/a n/a
62 2F8G Ki = 2 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
63 5IVQ - 6EH C24 H31 N3 O4 COC(=O)N[C....
64 4CPQ - 9MW C43 H58 N6 O6 CC(C)[C@@H....
65 1MT9 - ARG PRO GLY ASN PHE LEU GLN SER ARG PRO n/a n/a
66 1B6L Ki = 5 nM PI4 C28 H43 N5 O6 CC(C)(C)NC....
67 6B3F - CKV C34 H34 F3 N3 O3 S C[C@H]1CN(....
68 2PWC Ki = 0.27 uM G3G C30 H33 N5 O4 S2 c1ccc(cc1)....
69 2HS1 Ki = 3.3 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
70 6OXW - NFJ C31 H44 N2 O8 S CCC(CC)CN(....
71 1W5V Ki = 7.1 nM BE3 C38 H38 F2 N2 O8 c1ccc2c(c1....
72 2R5Q Ki = 2.7 nM 1UN C32 H45 N3 O4 S Cc1c(cccc1....
73 3M9F ic50 = 0.007 nM 595 C35 H46 N4 O6 S C[C@@H](CC....
74 6DGX Ki < 5 pM 017 C27 H37 N3 O7 S CC(C)C[N@@....
75 3MXD Ki = 1.47 nM K53 C31 H35 N3 O9 S CC(C)C[N@@....
76 2Q5K Ki = 0.005 nM AB1 C37 H48 N4 O5 Cc1cccc(c1....
77 4CPW - V78 C40 H55 N5 O6 S CC(C)[C@H]....
78 2AVV Ki = 0.55 nM MK1 C36 H47 N5 O4 CC(C)(C)NC....
79 4LL3 Kd = 2.7 pM 017 C27 H37 N3 O7 S CC(C)C[N@@....
80 6OOT - 017 C27 H37 N3 O7 S CC(C)C[N@@....
81 2AOH Ki = 36.3 uM VAL SER PHE ASN FRD PRO GLN ILE THR ALA n/a n/a
82 3ZPS - EQM C36 H52 Br N5 O6 CC(C)(C)[C....
83 3D1Z Ki = 1.6 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
84 1FG6 - 2NC C35 H68 N11 O8 CCCC[C@@H]....
85 1T3R Ki = 14 pM 017 C27 H37 N3 O7 S CC(C)C[N@@....
86 4HE9 Ki = 3.5 nM G52 C30 H40 N2 O9 S CC(C)C[N@@....
87 6OY0 - NJ7 C30 H42 N2 O9 S CC[C@H](C)....
88 1BV7 Ki = 0.5 nM XV6 C41 H38 N6 O5 S2 c1ccc(cc1)....
89 1HPS Ki = 0.6 nM RUN C38 H46 N4 O5 CC(C)[C@@H....
90 6O48 Ki = 75 nM 0Q4 C40 H70 N11 O8 CCCC[C@@H]....
91 2I4U Ki = 2.7 pM DJR C28 H38 N2 O8 S CC(C)C[N@@....
92 5AH9 - C7L C30 H43 N3 O9 S CC(C)CN(C[....
93 5IVR - 6EG C34 H38 N4 O4 COC(=O)N[C....
94 6DH0 Ki = 25.6 pM 017 C27 H37 N3 O7 S CC(C)C[N@@....
95 4EJL Kd = 7.2 uM IOP C11 H11 N O2 c1ccc2c(c1....
96 6KMP - KVS C36 H68 N10 O10 [H]/N=C(N)....
97 6PJL Ki = 0.027 nM OQA C33 H45 N3 O8 CC[C@@H](C....
98 3LZS Kd = 0.0109 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
99 2NXD Kd = 2.2 uM GLY ALA ASP ILE PHE TYR LEU ASP GLY ALA n/a n/a
100 3S56 Ki = 0.24 nM ROC C38 H50 N6 O5 CC(C)(C)NC....
101 5COK - 52U C29 H40 N2 O8 S CC(C)CN(C[....
102 6PJG Ki = 0.019 nM ORV C30 H39 N3 O8 C[C@@H](C(....
103 3FX5 Ki < 1 nM KNI C33 H41 N5 O6 S2 CC(C)(C)NC....
104 5JG1 Ki = 1.9 nM 6KR C33 H50 N2 O8 S CC(C)CN(C[....
105 6OXZ - NJG C30 H42 N2 O9 S CC[C@H](C)....
106 2NNP - ROC C38 H50 N6 O5 CC(C)(C)NC....
107 3KFN - 4DX C7 H14 O C[C@H]1CCC....
108 3R0W ic50 = 30.3 uM RSY C31 H43 Cl N6 O6 CC(C)C[C@@....
109 4KB9 Ki = 0.01 nM G79 C32 H44 N2 O8 S CC(C)CN(C[....
110 6DV0 Ki = 0.38 nM GA8 C36 H47 N3 O7 S2 CC(C)CN(C[....
111 1VIK ic50 = 0.3 nM BAY C64 H82 N4 O10 S2 CC(C)[C@@H....
112 1XL5 Ki = 45 nM 190 C31 H37 Br F N O5 S Cc1cccc(c1....
113 2I4X Ki = 1.9 pM KGQ C33 H49 N2 O12 P S CCOP(=O)(C....
114 4HVP Ki = 0.78 uM 2NC C35 H68 N11 O8 CCCC[C@@H]....
115 2JE4 - ACE SER LEU ASN JG3 ILE VME n/a n/a
116 4OBJ - ARG PRO GLY ASN PHE LEU GLN ASN ARG PRO n/a n/a
117 1FFI - 2NC C35 H68 N11 O8 CCCC[C@@H]....
118 4CPR Ki = 35 nM 378 C42 H57 N5 O6 S CC(C)[C@@H....
119 1C70 Ki = 0.05 nM L75 C39 H48 N4 O5 CC(C)(C)NC....
120 1B6P Ki = 3 nM PI7 C36 H53 N5 O7 CC[C@H](C)....
121 6OXQ - F53 C30 H42 N2 O8 S CCC(CC)C[N....
122 2QI0 Ki = 42 nM MZ3 C30 H31 F N2 O5 S2 Cc1c(cccc1....
123 2Q3K - MUW C34 H46 N4 O6 S CC(C)C[N@@....
124 2R3T Ki = 1.4 uM G4G C32 H33 N5 O6 S2 c1ccc(cc1)....
125 1MTR Ki = 4 nM PI6 C33 H48 N4 O6 CC[C@H](C)....
126 5KR2 Ki = 3.3 nM ROC C38 H50 N6 O5 CC(C)(C)NC....
127 3NU5 Ki = 4.5 nM 478 C25 H35 N3 O6 S CC(C)C[N@]....
128 6VCE ic50 = 79 pM G6R C34 H42 F2 N4 O6 S2 CC(C)CN(C[....
129 3JVY - 017 C27 H37 N3 O7 S CC(C)C[N@@....
130 1ZTZ Ki = 66 nM CB5 C4 H22 B18 Co [B@H]12[BH....
131 2NXM Kd = 6.4 uM GLY ALA GLN THR PHE TYR VAL ASP GLY ALA n/a n/a
132 4E43 - ASN LEU LEU GLN LYS LYS n/a n/a
133 1D4S Ki = 0.008 nM TPV C31 H33 F3 N2 O5 S CCC[C@]1(C....
134 3PWM - 017 C27 H37 N3 O7 S CC(C)C[N@@....
135 2AOD Ki = 2.17 uM UNX 2NC n/a n/a
136 5COP - 53F C29 H41 N3 O9 S CC(C)CN(C[....
137 2UXZ Ki = 3.3 nM HI1 C36 H45 Br N4 O6 CC(C)(C)[C....
138 4ZLS Ki = 0.82 nM G61 C34 H46 N2 O8 S CC(C)CN(C[....
139 5BS4 Ki = 0.0099 nM 4UX C28 H40 N4 O7 S CC(C)CN(C[....
140 6D0D - FQ4 C29 H39 F N2 O8 S CC(C)CN(C[....
141 3EKW Kd = 10.9 nM DR7 C38 H52 N6 O7 CC(C)(C)[C....
142 3I8W Ki = 4.9 nM CB5 C4 H22 B18 Co [B@H]12[BH....
143 3OTY - GLU THR PHE TYR VAL ASP GLY n/a n/a
144 6DJ5 - G52 C30 H40 N2 O9 S CC(C)C[N@@....
145 4CP7 Ki = 7.8 nM 9MW C43 H58 N6 O6 CC(C)[C@@H....
146 6PJK Ki = 0.055 nM OQD C33 H45 N3 O8 CC[C@H](C)....
147 1MT8 - LYS ALA ARG VAL LEU ALA GLU ALA MET SER n/a n/a
148 2HS2 Ki = 4.9 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
149 4EJK Kd = 5.3 uM IOP C11 H11 N O2 c1ccc2c(c1....
150 3EL1 Kd = 0.23 nM DR7 C38 H52 N6 O7 CC(C)(C)[C....
151 3DCK - KVI C36 H66 N10 O9 [H]/N=C(/N....
152 2Z4O Ki = 0.27 nM 065 C28 H36 N2 O9 S CC(C)C[N@@....
153 4DJO Ki = 0.003 nM MK5 C27 H37 Cl2 N3 O7 S CC[C@H](C)....
154 1PRO Ki = 5 pM A88 C34 H37 N3 O6 COc1cc(ccc....
155 1QBR Ki = 0.027 nM XV6 C41 H38 N6 O5 S2 c1ccc(cc1)....
156 1T7K Ki = 1.37 nM BH0 C32 H30 N4 O6 S c1ccc(cc1)....
157 1HVI Ki = 84 pM A77 C44 H58 N8 O6 CC(C)[C@@H....
158 2BPZ Ki = 39.8 nM 3IN C37 H55 Cl N8 O5 C[C@H]1CC[....
159 4QJA - ARG PRO GLY ASN PHE LEU GLN SER ARG LEU n/a n/a
160 1MET Ki = 0.4 nM DMP C35 H38 N2 O5 c1ccc(cc1)....
161 6PJD Ki = 0.018 nM OQY C33 H45 N3 O8 CC(C)(C)[C....
162 2QHZ Ki = 53 nM MZ2 C26 H24 F6 N2 O4 S2 C/C(=CC(=O....
163 6B36 - CKD C33 H32 F3 N3 O3 S c1ccc(cc1)....
164 4DQH - 017 C27 H37 N3 O7 S CC(C)C[N@@....
165 4Q1W Ki = 2 pM 017 C27 H37 N3 O7 S CC(C)C[N@@....
166 1N49 - RIT C37 H48 N6 O5 S2 CC(C)c1nc(....
167 1AXA - U0E C28 H52 N8 O6 CC(C)[C@H]....
168 6DGY Ki < 5 pM K13 C28 H39 N3 O7 S CC[C@H](C)....
169 3ZPT Ki = 3.1 nM M8Y C36 H50 Br N5 O6 CC(C)[C@H]....
170 2AZ9 ic50 = 22 nM 3TL C50 H64 N6 O10 C[C@@H](C(....
171 1W5Y Ki = 3.3 nM BE6 C38 H36 F4 N2 O8 c1ccc2c(c1....
172 1IZI Ki = 0.26 nM Q50 C38 H47 N5 O7 CC(C)(C)OC....
173 1MRW Kd = 0.2 nM K57 C28 H37 N3 O5 S Cc1c(cccc1....
174 1Z1H Ki = 4 nM HBB C30 H43 N3 O6 S CC(C)CC[N@....
175 1K2C - 0Q4 C40 H70 N11 O8 CCCC[C@@H]....
176 1ODX - 0E8 C30 H45 N3 O6 CC(C)(C)OC....
177 4QJ9 - ARG PRO GLY ASN PHE LEU GLN SER SER PRO n/a n/a
178 1NPA ic50 = 2 nM 3NH C36 H43 N3 O7 c1ccc(cc1)....
179 3EL5 Kd = 18.9 nM 1UN C32 H45 N3 O4 S Cc1c(cccc1....
180 2AOE Ki = 0.024 uM 0Q4 C40 H70 N11 O8 CCCC[C@@H]....
181 6OXT - NEJ C30 H42 N2 O8 S CC[C@H](C)....
182 1K6V Kd = 120 nM XN2 C39 H50 N4 O6 C[C@H](c1c....
183 3SPK ic50 = 3.02 nM TPV C31 H33 F3 N2 O5 S CCC[C@]1(C....
184 6DJ2 Ki = 4.5 nM AB1 C37 H48 N4 O5 Cc1cccc(c1....
185 6BZ2 Ki = 14 pM 7OA C33 H40 F2 N4 O7 S2 CC(C)CN(C[....
186 2Q64 Kd = 3 nM 1UN C32 H45 N3 O4 S Cc1c(cccc1....
187 1EBW Ki = 0.9 nM BEI C34 H50 N4 O8 CC[C@H](C)....
188 3NU4 Ki = 1.5 nM 478 C25 H35 N3 O6 S CC(C)C[N@]....
189 1WBM - BLL C40 H44 N2 O6 c1ccc(cc1)....
190 5JFP Ki = 0.48 nM 6KK C32 H48 N2 O8 S CC(C)CN(C[....
191 3D1X Ki = 2.2 nM ROC C38 H50 N6 O5 CC(C)(C)NC....
192 1QBU Ki = 0.058 nM 846 C34 H36 N4 O4 S c1ccc(cc1)....
193 1HTF ic50 = 148 nM G26 C32 H38 N4 O4 S CC1([C@@H]....
194 2I0D Ki = 0.0008 nM MUT C33 H39 N3 O8 S CC(C)C[N@@....
195 1NPW ic50 = 2 nM LGZ C36 H39 N3 O7 c1ccc(cc1)....
196 1AJX Ki = 12.2 nM AH1 C33 H34 N2 O5 c1ccc(cc1)....
197 1GNO Ki = 20 nM U0E C28 H52 N8 O6 CC(C)[C@H]....
198 3AID Ki = 137 nM ARQ C30 H38 N3 O4 CC(C)(C)OC....
199 1D4K Ki = 0.6 nM PI8 C41 H54 N4 O6 CC[C@H](C)....
200 1FFF - 0Q4 C40 H70 N11 O8 CCCC[C@@H]....
201 4PHV ic50 = 0.67 nM VAC C39 H42 N2 O5 c1ccc(cc1)....
202 5DGW Ki = 0.009 nM 5B5 C31 H45 N3 O8 S CCN[C@H]1C....
203 6OY2 - NJJ C31 H44 N2 O9 S CCC(CC)CN(....
204 6PJH Ki = 0.074 nM OQG C32 H43 N3 O8 CC(C)[C@@H....
205 1NH0 Ki = 0.18 nM KI2 PHE GLU GLU NH2 n/a n/a
206 6U7P - B4R C28 H39 B N2 O9 S B(c1ccc(cc....
207 1ODW Ki = 100 nM 0E8 C30 H45 N3 O6 CC(C)(C)OC....
208 2BBB ic50 = 2.4 nM HH1 C37 H41 N3 O6 c1ccc(cc1)....
209 4U7Q Ki = 180 pM 3EM C43 H51 N5 O8 S CCN(CC)c1c....
210 3OTS - GLN ASN TYR PRO ILE VAL GLN n/a n/a
211 6DIL Ki = 7.6 nM TPV C31 H33 F3 N2 O5 S CCC[C@]1(C....
212 4CPS - 1T8 C41 H54 N6 O6 CC(C)[C@H]....
213 2NMY - ROC C38 H50 N6 O5 CC(C)(C)NC....
214 2QCI Ki = 4.6 nM 065 C28 H36 N2 O9 S CC(C)C[N@@....
215 2AVQ Ki = 41 uM 2NC C35 H68 N11 O8 CCCC[C@@H]....
216 1DAZ - 0Q4 C40 H70 N11 O8 CCCC[C@@H]....
217 5CON - 52W C29 H40 N2 O9 S CC(C)CN(C[....
218 4QJ8 - ARG PRO GLY ASN PHE LEU GLN SER ARG LEU n/a n/a
219 1U8G - KI2 PHE GLU GLU NH2 n/a n/a
220 1IZH Ki = 0.02 uM Q50 C38 H47 N5 O7 CC(C)(C)OC....
221 6OGP ic50 = 0.055 uM MJD C33 H42 F2 N4 O8 S CC(C)CN(C[....
222 6OXP - K2A C29 H40 N2 O8 S CC[C@H](C)....
223 1SH9 Ki = 932 nM RIT C37 H48 N6 O5 S2 CC(C)c1nc(....
224 1MTB - QNC ASN HPH DIQ NTB n/a n/a
225 1FG8 - 0Q4 C40 H70 N11 O8 CCCC[C@@H]....
226 1TSU - ARG GLN ALA ASN PHE LEU GLY LYS n/a n/a
227 1C6X - 3IN C37 H55 Cl N8 O5 C[C@H]1CC[....
228 1A9M Ki = 119 nM U0E C28 H52 N8 O6 CC(C)[C@H]....
229 3EL4 Kd = 67.4 nM ROC C38 H50 N6 O5 CC(C)(C)NC....
230 1D4H Ki = 0.1 nM BEH C36 H38 N2 O7 c1ccc(cc1)....
231 6DV4 Ki = 1.6 nM GA5 C37 H49 N3 O8 S CC(C)CN(C[....
232 2IEN Ki = 1 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
233 6DH2 Ki = 12.8 pM A60 C29 H41 N3 O7 S CCC(CC)C[N....
234 1SP5 - TYR ASP GLN ILE LEU n/a n/a
235 5IVT ic50 = 0.8 nM 6EE C30 H30 Cl F6 N5 O4 c1cc(ccc1[....
236 6C8X Ki = 0.5 pM BVR C27 H36 B N2 O9 S B(=O)(c1cc....
237 2FDD ic50 = 4.8 nM 385 C33 H41 N3 O10 S2 Cc1nc(cs1)....
238 1VIJ ic50 = 0.3 nM BAY C64 H82 N4 O10 S2 CC(C)[C@@H....
239 2BPY Ki = 39.8 nM 3IN C37 H55 Cl N8 O5 C[C@H]1CC[....
240 4HDP Ki = 30.9 nM G52 C30 H40 N2 O9 S CC(C)C[N@@....
241 6E7J Ki = 0.33 nM HWY C34 H41 N3 O8 S CC(C)CN(C[....
242 6MCR - JDY C33 H41 F N4 O7 S2 CC(C)CN(C[....
243 2AVM Ki = 2 uM 2NC C35 H68 N11 O8 CCCC[C@@H]....
244 6PU8 - P3V C27 H37 N3 O8 S CC(C)CN(CC....
245 3CYX Ki = 10 nM ROC C38 H50 N6 O5 CC(C)(C)NC....
246 1QBS Ki = 0.34 nM DMP C35 H38 N2 O5 c1ccc(cc1)....
247 1EBK - 0Q4 C40 H70 N11 O8 CCCC[C@@H]....
248 5UOV Ki = 0.025 nM 8FP C37 H44 N4 O6 S2 Cc1csc(n1)....
249 2FNS - ARG GLN ALA ASN PHE LEU GLY LYS ILE ASN n/a n/a
250 3EKX Kd = 0.39 nM 1UN C32 H45 N3 O4 S Cc1c(cccc1....
251 5UPZ Ki = 0.63 nM 8HD C35 H42 N4 O7 S Cc1coc(n1)....
252 2QI6 Ki = 0.027 nM MZ8 C28 H31 N3 O5 S2 CC(C)C[N@@....
253 6OTG Ki = 31.4 nM 4UY C29 H41 N3 O8 S CC(C)CN(C[....
254 1EBY Ki = 0.2 nM BEB C38 H40 N2 O8 c1ccc(cc1)....
255 3BGC Ki = 9.6 uM LJH C30 H35 N5 O4 S2 c1ccc(cc1)....
256 1CPI - ASN RTY PRO ILE VAL NH2 n/a n/a
257 1ZLF Ki = 1000 nM 0ZR C38 H50 N6 O7 CC(C)(C)OC....
258 1K1U - 0Q4 C40 H70 N11 O8 CCCC[C@@H]....
259 2I4D Ki = 2.1 pM QFI C29 H41 N2 O12 P S CC(C)C[N@@....
260 3GI6 Ki = 0.006 nM D78 C32 H36 F3 N3 O7 S CC(C)C[N@@....
261 3OUB - GLN VAL ASN PHE LEU GLY LYS n/a n/a
262 1OHR Ki = 2 nM 1UN C32 H45 N3 O4 S Cc1c(cccc1....
263 3CYW Ki = 17 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
264 6OXS - NJ4 C29 H40 N2 O8 S C[C@H](c1c....
265 2A1E - IPF C50 H64 N8 O8 CC(C)[C@@H....
266 3JVW - DMP C35 H38 N2 O5 c1ccc(cc1)....
267 1HWR Ki = 4.7 nM 216 C25 H30 N2 O3 C=CCN1[C@@....
268 2BQV Ki = 9 nM A1A C33 H40 N4 O6 CC(C)[C@@H....
269 2AOG Ki = 0.53 uM 2NC C35 H68 N11 O8 CCCC[C@@H]....
270 1UPJ - U01 C19 H17 Br O3 CC(C)[C@@H....
271 1DW6 - 0Q4 C40 H70 N11 O8 CCCC[C@@H]....
272 1BWA Ki = 2.5 nM XV6 C41 H38 N6 O5 S2 c1ccc(cc1)....
273 2AQU Ki = 0.48 nM DR7 C38 H52 N6 O7 CC(C)(C)[C....
274 3EKQ Kd = 176 nM ROC C38 H50 N6 O5 CC(C)(C)NC....
275 2QHY Ki = 33 nM MZ1 C26 H28 F3 N3 O5 S2 C[C@@H](C(....
276 1ZPA Ki = 4 nM A83 C37 H48 N6 O7 S CC(C)CN(C[....
277 1SDT Ki = 540 pM MK1 C36 H47 N5 O4 CC(C)(C)NC....
278 2QD6 Ki = 2.1 nM 065 C28 H36 N2 O9 S CC(C)C[N@@....
279 3NWX - KVS C36 H68 N10 O10 [H]/N=C(N)....
280 1G2K Ki = 11 nM NM1 C34 H37 N3 O7 S CNC(=O)c1c....
281 6VOD ic50 = 38 nM T1R C30 H40 N2 O8 S CC(C)CN(C[....
282 6PJI Ki = 0.571 nM OO4 C32 H41 N3 O8 COC(=O)N[C....
283 4DJP Ki = 0.028 nM M73 C28 H40 N2 O8 S CC[C@H](C)....
284 2PQZ Ki = 2.15 uM G0G C30 H31 N3 O4 S2 c1ccc(cc1)....
285 2CEN Ki = 5 nM 4AH C39 H45 N5 O6 CC(C)(C)[C....
286 2J9K - 2NC C35 H68 N11 O8 CCCC[C@@H]....
287 2PWR Ki = 0.26 uM G4G C32 H33 N5 O6 S2 c1ccc(cc1)....
288 2NPH - TYR VAL ASP GLY ALA n/a n/a
289 1HVH Ki = 11 nM Q82 C36 H38 N4 O4 c1ccc(cc1)....
290 1ZJ7 Ki = 86 nM 0ZT C38 H49 N5 O8 CC(C)(C)OC....
291 1SDV Ki = 1810 pM MK1 C36 H47 N5 O4 CC(C)(C)NC....
292 3EL0 Kd = 34.1 nM 1UN C32 H45 N3 O4 S Cc1c(cccc1....
293 3HAU Kd = 0.42 uM 2NC C35 H68 N11 O8 CCCC[C@@H]....
294 3ST5 Ki = 5 pM G89 C29 H40 N2 O8 S CC(C)C[N@@....
295 5KQZ - 0Q4 C40 H70 N11 O8 CCCC[C@@H]....
296 2QI7 Ki = 0.062 nM MZ9 C28 H40 N2 O6 S CC[C@H](C)....
297 1HPX Ki = 5.5 pM KNI C33 H41 N5 O6 S2 CC(C)(C)NC....
298 3BVB Ka = 3170000 M^-1 017 C27 H37 N3 O7 S CC(C)C[N@@....
299 5KR0 Ki = 0.71 nM 478 C25 H35 N3 O6 S CC(C)C[N@]....
300 1W5W Ki = 1.6 nM BE4 C38 H36 F4 N2 O8 c1ccc2c(c1....
301 2NXL Kd = 0.54 uM GLY ALA GLU VAL PHE TYR VAL ASP GLY ALA n/a n/a
302 4TVH - 3TL C50 H64 N6 O10 C[C@@H](C(....
303 1K6T Kd = 24 nM XN1 C37 H49 N5 O4 C[C@H](c1c....
304 6OXV - NF4 C31 H44 N2 O8 S CCC(CC)CN(....
305 2R43 Ki = 1 uM G3G C30 H33 N5 O4 S2 c1ccc(cc1)....
306 6OOS - 017 C27 H37 N3 O7 S CC(C)C[N@@....
307 7HVP Ki = 0.24 nM ACE SER LEU ASN JG3 ILE VME n/a n/a
308 2R5P Ki = 3.3 nM MK1 C36 H47 N5 O4 CC(C)(C)NC....
309 6OY1 - NJ1 C31 H44 N2 O9 S CCC(CC)CN(....
310 1LZQ Ki = 4.1 nM 0ZQ C38 H49 N5 O7 CC(C)(C)OC....
311 1A94 Ki = 14 nM 0Q4 C40 H70 N11 O8 CCCC[C@@H]....
312 1HVK Ki = 77 pM A79 C44 H58 N8 O6 CC(C)[C@@H....
313 6DH1 Ki = 26.1 pM K13 C28 H39 N3 O7 S CC[C@H](C)....
314 2R38 Ki = 0.036 uM G4G C32 H33 N5 O6 S2 c1ccc(cc1)....
315 3BXS Ki = 8 uM DRS C19 H26 N2 O5 CC(C)[C@H]....
316 2QD7 Ki = 0.8 nM 065 C28 H36 N2 O9 S CC(C)C[N@@....
317 6B3C - CKS C34 H34 F3 N3 O3 S C[C@@H]1CN....
318 3DK1 Ki = 0.18 nM G05 C29 H40 N2 O8 S CC(C)C[N@@....
319 2BB9 ic50 = 0.44 nM AKC C36 H39 N3 O7 CCOCCOC(=O....
320 1HEG Ki = 18 nM PSI C29 H47 N5 O7 C[C@@H](C(....
321 6OPT - 017 C27 H37 N3 O7 S CC(C)C[N@@....
322 4FL8 - GLN ILE IL0 ILE GLU ILE ALA n/a n/a
323 4Q1Y Ki = 45 pM 017 C27 H37 N3 O7 S CC(C)C[N@@....
324 2FGV Kd = 760 nM QNC ASN HPH DIQ NTB n/a n/a
325 1EC0 Ki = 3.2 nM BED C38 H38 F2 N2 O8 c1ccc2c(c1....
326 1K6C Kd = 33 nM MK1 C36 H47 N5 O4 CC(C)(C)NC....
327 1MSN Kd < 1 nM JE2 C32 H37 N3 O5 S Cc1ccccc1C....
328 6DGZ Ki < 5 pM A60 C29 H41 N3 O7 S CCC(CC)C[N....
329 2PSV Ki = 58 nM MUV C23 H31 N3 O6 S CNC(=O)CCC....
330 1DMP Ki = 0.28 nM DMQ C33 H36 N4 O3 c1ccc(cc1)....
331 2QNP Ki = 0.39 uM QN2 C30 H29 I2 N3 O4 S2 c1ccc(cc1)....
332 3S53 Ki = 0.23 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
333 1HXB Ki = 0.12 nM ROC C38 H50 N6 O5 CC(C)(C)NC....
334 1HSG Ki = 0.38 nM MK1 C36 H47 N5 O4 CC(C)(C)NC....
335 1IIQ Ki = 33 nM 0ZR C38 H50 N6 O7 CC(C)(C)OC....
336 2AZ8 ic50 = 6 nM 3TL C50 H64 N6 O10 C[C@@H](C(....
337 4QJ7 - ARG PRO GLY ASN PHE LEU GLN SER SER PRO n/a n/a
338 5TYR ic50 = 0.26 nM 7O7 C33 H42 N4 O7 S2 CC(C)CN(C[....
339 2QI1 Ki = 50 nM MZ4 C29 H30 N2 O7 S2 COc1cccc(c....
340 1RL8 - RIT C37 H48 N6 O5 S2 CC(C)c1nc(....
341 2AVO Ki = 1.4 nM MK1 C36 H47 N5 O4 CC(C)(C)NC....
342 6B4N Ki = 27.9 pM G53 C32 H39 N3 O10 S CC(C)CN(C[....
343 3NU6 Ki = 0.5 nM 478 C25 H35 N3 O6 S CC(C)C[N@]....
344 6PJO Ki = 0.161 nM OQ7 C34 H45 N3 O8 COC(=O)N[C....
345 3DCR ic50 = 6.3 nM KVS C36 H68 N10 O10 [H]/N=C(N)....
346 1YTG - PRO ILE VAL NH2 n/a n/a
347 4FE6 Ki < 0.1 nM 0TQ C32 H42 N4 O8 S CC(C)CN(C[....
348 5BRY Ki = 0.0015 nM 4UY C29 H41 N3 O8 S CC(C)CN(C[....
349 4DJQ Ki = 0.048 nM M86 C28 H40 N4 O7 S CC[C@H](C)....
350 1HXW Ki = 15 pM RIT C37 H48 N6 O5 S2 CC(C)c1nc(....
351 4HDB Ki = 8.9 nM G52 C30 H40 N2 O9 S CC(C)C[N@@....
352 1T7I - 017 C27 H37 N3 O7 S CC(C)C[N@@....
353 1KJG - GLY ALA GLU THR PHE TYR VAL ASP GLY ALA n/a n/a
354 4OBG - ARG PRO GLY ASN PHE LEU GLN SER ARG PRO n/a n/a
355 1AAQ Ki = 3 nM PSI C29 H47 N5 O7 C[C@@H](C(....
356 3NU9 Ki = 0.9 nM 478 C25 H35 N3 O6 S CC(C)C[N@]....
357 2QNQ Ki = 0.77 uM QN3 C30 H29 Cl2 N3 O4 S2 c1ccc(cc1)....
358 5DGU Ki = 0.0045 nM 5B7 C30 H42 N2 O9 S CC(C)CN(C[....
359 4A6C Ki = 4.2 nM QG9 C43 H51 N5 O6 CC(C)(C)[C....
360 5KQY Ki = 0.51 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
361 1MRX Kd = 55 nM K57 C28 H37 N3 O5 S Cc1c(cccc1....
362 2UY0 Ki = 120 nM HV1 C36 H43 Br N4 O7 CC(C)(C)[C....
363 2QD8 Ki = 0.85 nM 065 C28 H36 N2 O9 S CC(C)C[N@@....
364 1HVJ Ki = 4 pM A78 C44 H60 N8 O5 CC(C)[C@@H....
365 3EKY Kd = 0.23 nM DR7 C38 H52 N6 O7 CC(C)(C)[C....
366 1T7J Kd = 0.000000064 M 478 C25 H35 N3 O6 S CC(C)C[N@]....
367 6B3G - CKY C34 H34 F3 N3 O3 S C[C@H]1CNC....
368 1MES Ki = 20 nM DMP C35 H38 N2 O5 c1ccc(cc1)....
369 6DIF Ki = 0.019 nM TPV C31 H33 F3 N2 O5 S CCC[C@]1(C....
370 3KDC Kd = 0.52 nM JZP C33 H35 Cl2 N3 O6 S CC1([C@H](....
371 3NUJ Ki = 0.41 nM 478 C25 H35 N3 O6 S CC(C)C[N@]....
372 6D0E - FQ1 C29 H38 F2 N2 O8 S CC(C)CN(C[....
373 2FLE Ki = 14 nM AI C44 H64 N8 O6 CC(C)[C@@H....
374 3HAW Kd = 1.01 uM 2NC C35 H68 N11 O8 CCCC[C@@H]....
375 3EKV Kd = 0.39 nM 478 C25 H35 N3 O6 S CC(C)C[N@]....
376 4QJ6 - ARG PRO GLY ASN PHE PHE GLN SER ARG PRO n/a n/a
377 2QI4 Ki = 0.036 nM MZ6 C29 H33 N3 O5 S2 CC[C@H](C)....
378 6OXU - NE7 C30 H42 N2 O8 S CC[C@H](C)....
379 5YOK - 8Z0 C41 H48 N4 O8 S Cc1cccc(c1....
380 6B38 - CKM C34 H34 F3 N3 O3 S C[C@@H]1CN....
381 3GI4 Ki = 0.016 nM K60 C32 H34 F3 N3 O8 S CC(C)C[N@@....
382 4OBF - ARG PRO GLY ASN PHE LEU GLN ASN ARG PRO n/a n/a
383 1GNN Ki = 2100 nM U0E C28 H52 N8 O6 CC(C)[C@H]....
384 2WKZ Ki = 1.7 nM 5AH C40 H47 N5 O6 CC(C)(C)[C....
385 5YOJ - 8Z0 C41 H48 N4 O8 S Cc1cccc(c1....
386 6VOE ic50 = 0.3 nM T2R C33 H44 N4 O8 S CC(C)CN(C[....
387 1ZSR Ki = 0.15 nM 0ZT C38 H49 N5 O8 CC(C)(C)OC....
388 6DH7 Ki = 131.3 pM K13 C28 H39 N3 O7 S CC[C@H](C)....
389 3BC4 Ki = 4.5 uM LLG C14 H15 N O2 c1ccc2c(c1....
390 2AOC Ki = 13 uM UNX 2NC n/a n/a
391 2ZGA Ki = 0.48 uM YDP C28 H37 N5 O6 S2 CC(=CCN([C....
392 3BGB Ki = 0.9 uM LJG C24 H39 N5 O4 S2 CC(C)CN(CC....
393 2PK6 Kd = 13 pM O33 C40 H45 N5 O7 S2 CC1([C@H](....
394 4A6B Ki = 12 nM QG8 C44 H52 N4 O6 CC(C)(C)[C....
395 4DJR Ki = 0.003 nM 0KJ C28 H36 N4 O6 S2 CC[C@H](C)....
396 5KQX Ki = 3.6 nM ROC C38 H50 N6 O5 CC(C)(C)NC....
397 1A8G Ki = 7.4 nM 2Z4 C46 H59 N5 O9 CC(C)[C@@H....
398 1HIH Ki = 9 nM C20 C31 H51 N5 O5 CC(C)[C@@H....
399 1KZK Ki = 41 pM JE2 C32 H37 N3 O5 S Cc1ccccc1C....
400 4Q1X Ki = 7 pM 017 C27 H37 N3 O7 S CC(C)C[N@@....
401 6BRA - SER GLY ILE PHE LEU GLU THR SER n/a n/a
402 2P3A Ki = 11 nM 3TL C50 H64 N6 O10 C[C@@H](C(....
403 3OU3 - LEU ASN PHE PRO ILE SER PRO n/a n/a
404 2Q55 Ki = 2.04 nM MU0 C37 H45 N5 O6 CC(C)[C@@H....
405 1HTG ic50 = 3.8 nM G37 C42 H47 N7 O5 S CC1([C@@H]....
406 2PYN Kd = 27 nM 1UN C32 H45 N3 O4 S Cc1c(cccc1....
407 2NNK - ROC C38 H50 N6 O5 CC(C)(C)NC....
408 1HPV Ki = 0.6 nM 478 C25 H35 N3 O6 S CC(C)C[N@]....
409 1D4J Ki = 4.4 nM MSC C36 H36 Cl F N2 O7 c1ccc(cc1)....
410 4DQB - 017 C27 H37 N3 O7 S CC(C)C[N@@....
411 1A8K - 0Q4 C40 H70 N11 O8 CCCC[C@@H]....
412 3NYG - 2NC C35 H68 N11 O8 CCCC[C@@H]....
413 3D20 Ki = 5 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
414 1FEJ - 2NC C35 H68 N11 O8 CCCC[C@@H]....
415 6OPS - 017 C27 H37 N3 O7 S CC(C)C[N@@....
416 6PJB - AB1 C37 H48 N4 O5 Cc1cccc(c1....
417 1C6Z - ROC C38 H50 N6 O5 CC(C)(C)NC....
418 5TYS ic50 = 0.019 nM 7OA C33 H40 F2 N4 O7 S2 CC(C)CN(C[....
419 2F81 Ki = 0.03 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
420 1KJ7 - PRO ALA THR ILE MET MET GLN ARG GLY ASN n/a n/a
421 3KF0 - 4DX C7 H14 O C[C@H]1CCC....
422 6DH4 Ki < 5 pM K13 C28 H39 N3 O7 S CC[C@H](C)....
423 3EL9 Kd = 4 nM DR7 C38 H52 N6 O7 CC(C)(C)[C....
424 1K2B - 0Q4 C40 H70 N11 O8 CCCC[C@@H]....
425 1ZP8 Ki = 1.7 nM AB2 C34 H41 N5 O7 S CC(C)CN(C[....
426 6DJ1 Ki = 0.031 nM AB1 C37 H48 N4 O5 Cc1cccc(c1....
427 3JW2 - 017 C27 H37 N3 O7 S CC(C)C[N@@....
428 2O4K Kd = 35 pM DR7 C38 H52 N6 O7 CC(C)(C)[C....
429 1HPO Ki = 0.6 nM UNI C28 H28 N2 O5 S c1cc(cc(c1....
430 3LZV Kd = 0.026 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
431 6DH3 Ki < 5 pM 017 C27 H37 N3 O7 S CC(C)C[N@@....
432 3H5B Ki = 0.099 nM 031 C30 H39 N3 O8 S COc1ccc(cc....
433 1AID Ki = 15 uM THK C23 H27 Cl F N O S2 c1cc(ccc1C....
434 1EC3 Ki = 0.92 nM MS3 C42 H52 N6 O8 CC(C)[C@@H....
435 3EKP Kd = 1.3 nM 478 C25 H35 N3 O6 S CC(C)C[N@]....
436 4EJ8 Kd = 4.1 uM 1F1 C9 H7 N O2 c1cc(cc2c1....
437 3I7E Ki = 14 pM DJR C28 H38 N2 O8 S CC(C)C[N@@....
438 2O4S Kd = 31 pM AB1 C37 H48 N4 O5 Cc1cccc(c1....
439 4EJD Kd = 14.5 uM 1F1 C9 H7 N O2 c1cc(cc2c1....
440 2Q54 Ki = 0.98 nM MU1 C37 H44 N4 O7 CC(C)[C@@H....
441 3KDD Kd = 3.45 nM JZQ C33 H35 F2 N3 O6 S CC1([C@H](....
442 2F80 Ki = 6.6 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
443 1TCX Ki = 112 nM IM1 C31 H42 N4 O4 CC(C)[C@@H....
444 5IVS ic50 = 6.1 nM 6EF C38 H42 N4 O6 COC(=O)N[C....
445 4QJ2 - ARG PRO GLY ASN PHE LEU GLN SER ARG PRO n/a n/a
446 8HVP Ki < 1 nM VAL SER GLN ASN LOV ILE VAL n/a n/a
447 3TL9 - ROC C38 H50 N6 O5 CC(C)(C)NC....
448 3TLH Ki = 1.5 nM 3TL C50 H64 N6 O10 C[C@@H](C(....
449 2QNN Ki = 0.07 uM QN1 C34 H31 F6 N5 O6 S2 c1cc(ccc1C....
450 3KFS - 3TL C50 H64 N6 O10 C[C@@H](C(....
451 6OYD ic50 = 0.12 nM NKA C33 H43 F N4 O8 S CC(C)CN(C[....
452 6CDL Ki = 0.012 nM GR5 C34 H42 F2 N4 O7 S2 CC(C)CN(C[....
453 1M0B Ki = 1.53 nM 0ZQ C38 H49 N5 O7 CC(C)(C)OC....
454 6OYR ic50 = 0.29 nM NJY C33 H43 F N4 O8 S CC(C)CN(C[....
455 2Q63 Kd = 66 nM 1UN C32 H45 N3 O4 S Cc1c(cccc1....
456 4QGI - ROC C38 H50 N6 O5 CC(C)(C)NC....
457 1D4Y Ki = 0.008 nM TPV C31 H33 F3 N2 O5 S CCC[C@]1(C....
458 6C8Y - BVR C27 H36 B N2 O9 S B(=O)(c1cc....
459 5KAO - G43 C29 H39 Cl N2 O9 S CC(C)CN(C[....
460 1SGU Ki = 4235 nM MK1 C36 H47 N5 O4 CC(C)(C)NC....
461 1A30 Ki = 50 uM GLU ASP LEU n/a n/a
462 2QI3 Ki = 0.063 nM MZ5 C27 H37 N3 O5 S2 CC[C@H](C)....
463 4EYR ic50 = 237 nM RIT C37 H48 N6 O5 S2 CC(C)c1nc(....
464 3D1Y Ki = 6 nM ROC C38 H50 N6 O5 CC(C)(C)NC....
465 6OOU - 017 C27 H37 N3 O7 S CC(C)C[N@@....
466 2PYM Kd = 150 nM 1UN C32 H45 N3 O4 S Cc1c(cccc1....
467 4U8W Ki = 0.0058 nM G10 C27 H35 F2 N3 O7 S CC(C)CN(C[....
468 2A4F - AAU C36 H39 N3 O8 COc1cc(ccc....
469 3B80 - ASN LEU LNT GLN ILE n/a n/a
470 6PJM Ki = 0.013 nM OQV C33 H45 N3 O8 CC(C)(C)[C....
471 4DQE - 017 C27 H37 N3 O7 S CC(C)C[N@@....
472 5KR1 Ki = 0.32 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
473 2I4W Ki = 2.6 pM KGQ C33 H49 N2 O12 P S CCOP(=O)(C....
474 5WLO Ki = 0.015 nM GR7 C32 H42 N2 O9 S COc1ccc2c(....
475 3OUA - GLY ASN PHE LEU GLN SER ARG n/a n/a
476 2R3W Ki = 0.128 uM G3G C30 H33 N5 O4 S2 c1ccc(cc1)....
477 3TKG - ROC C38 H50 N6 O5 CC(C)(C)NC....
478 3GI5 Ki = 0.006 nM K62 C33 H37 N3 O9 S CC(C)C[N@@....
479 6OXY - NG4 C29 H40 N2 O9 S CC(C)CN(C[....
480 1BWB Ki = 3.8 nM 146 C49 H44 N8 O5 c1ccc(cc1)....
481 4K4Q - 06B C9 H9 Br O4 COc1ccc(c(....
482 1WBK - 568 C34 H40 N2 O9 c1ccc(cc1)....
483 3EKT Kd = 0.026 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
484 1C6Y Ki = 0.31 nM MK1 C36 H47 N5 O4 CC(C)(C)NC....
485 2O4L Kd = 608 pM TPV C31 H33 F3 N2 O5 S CCC[C@]1(C....
486 3OXC Ki = 3.9 nM ROC C38 H50 N6 O5 CC(C)(C)NC....
487 3BVA Ka = 3300000 M^-1 2NC C35 H68 N11 O8 CCCC[C@@H]....
488 1MSM Kd = 33 pM JE2 C32 H37 N3 O5 S Cc1ccccc1C....
489 2AZB ic50 = 64 nM 3TL C50 H64 N6 O10 C[C@@H](C(....
490 4I8W Ki = 12.7 pM G07 C28 H36 N2 O9 S CC(C)CN(C[....
491 2CEM Ki = 12 nM 2AH C39 H45 N5 O6 CC(C)(C)[C....
492 6PJC Ki = 0.017 nM OR1 C35 H42 N2 O7 Cc1cccc(c1....
493 4CPX - J3W C40 H53 N5 O6 S CC(C)[C@H]....
494 4GYE - ILO VAL PUK GLU ALA NLE n/a n/a
495 1B6M Ki = 4 nM PI6 C33 H48 N4 O6 CC[C@H](C)....
496 5ULT Ki = 0.014 nM 8FM C30 H40 N2 O8 S CC(C)CN(C[....
497 2WL0 Ki = 16 nM 5AH C40 H47 N5 O6 CC(C)(C)[C....
498 1HEF Ki = 1 nM ALA ALA PJJ VAL VME n/a n/a
499 4TVG - IVA VAL VAL STA ALA STA n/a n/a
500 1F7A - LYS ALA ARG VAL LEU ALA GLU ALA MET SER n/a n/a
501 3LZU Kd = 0.087 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
502 4OBK - ARG PRO GLY ASN PHE PHE GLN ASN ARG PRO n/a n/a
503 3TH9 Ki = 20 nM 9Y9 C25 H33 F N2 O5 S C[C@H]1Cc2....
504 3NUO Ki = 0.16 nM 478 C25 H35 N3 O6 S CC(C)C[N@]....
505 3KFP - 3TL C50 H64 N6 O10 C[C@@H](C(....
506 2O4P Kd = 19 pM TPV C31 H33 F3 N2 O5 S CCC[C@]1(C....
507 3A2O Ki = 0.83 nM KNJ C30 H40 N4 O5 S Cc1cc(cc(c....
508 1BV9 Ki = 1.1 nM XV6 C41 H38 N6 O5 S2 c1ccc(cc1)....
509 1HVL Ki = 1000 pM A76 C44 H58 N8 O6 CC(C)[C@@H....
510 3OUC - THR ILE MET MET GLN ARG GLY n/a n/a
511 1K1T - 0Q4 C40 H70 N11 O8 CCCC[C@@H]....
512 1XL2 Ki = 1.5 uM 189 C33 H43 N3 O4 S Cc1cccc(c1....
513 1ODY Ki = 8 nM LP1 C45 H58 N6 O7 CC[C@@H](C....
514 2PK5 Kd = 20 pM 075 C40 H45 N5 O9 S2 CC1([C@H](....
515 2CEJ Ki = 2.4 nM 1AH C34 H41 Br N4 O6 CC(C)(C)[C....
516 3PWR - ROC C38 H50 N6 O5 CC(C)(C)NC....
517 1FF0 - 2NC C35 H68 N11 O8 CCCC[C@@H]....
518 4OBD - ARG PRO GLY ASN PHE PHE GLN ASN ARG PRO n/a n/a
519 3I6O Ki = 45 pM GR6 C32 H42 N2 O9 S COc1ccc2c(....
520 1TSQ - ARG GLN VAL ASN PHE LEU GLY LYS ILE ASN n/a n/a
521 1MEU Ki = 0.8 uM DMP C35 H38 N2 O5 c1ccc(cc1)....
522 6PJE Ki = 46 nM OPJ C33 H43 N3 O8 COC(=O)NC1....
523 2FXE - DR7 C38 H52 N6 O7 CC(C)(C)[C....
524 1HOS Ki = 2.8 nM PHP C42 H51 N4 O8 P CC(C)[C@@H....
525 1MT7 - VAL SER GLN ASN TYR PRO ILE VAL GLN ASN n/a n/a
526 1HVS Ki = 50 pM A77 C44 H58 N8 O6 CC(C)[C@@H....
527 3R0Y ic50 = 14.53 uM RSZ C34 H39 N5 O5 CC(C)[C@@H....
528 1FGC - 2NC C35 H68 N11 O8 CCCC[C@@H]....
529 4CPT Ki = 20 nM 1T8 C41 H54 N6 O6 CC(C)[C@H]....
530 1DIF Ki = 22 pM A85 C44 H56 F2 N8 O6 CC(C)[C@@H....
531 1D4L Ki = 1.7 nM PI9 C32 H48 N4 O6 S CC(C)CC[N@....
532 4OBH - ARG PRO GLY ASN PHE PHE GLN SER ARG PRO n/a n/a
533 3KFR - 3TL C50 H64 N6 O10 C[C@@H](C(....
534 2I0A Ki = 0.004 nM MUI C33 H39 N3 O8 S CC(C)C[N@@....
535 6PJN Ki = 7.3 nM OQP C33 H43 N3 O8 COC(=O)NC1....
536 1EC1 Ki = 1.2 nM BEE C40 H50 N4 O8 S2 CC(C)[C@@H....
537 6DH6 Ki = 117.2 pM 017 C27 H37 N3 O7 S CC(C)C[N@@....
538 1ZSF Ki = 0.12 nM 0ZS C38 H49 N5 O8 CC(C)(C)OC....
539 2FGU Kd = 0.66 nM QNC ASN HPH DIQ NTB n/a n/a
540 3NU3 Ki = 0.15 nM 478 C25 H35 N3 O6 S CC(C)C[N@]....
541 2FNT - ARG GLN VAL ASN PHE LEU GLY LYS ILE ASN n/a n/a
542 1KJH - ILE ARG LYS ILE LEU PHE LEU ASP GLY ILE n/a n/a
543 3S54 Ki = 0.23 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
544 6U7O Ki = 15.5 uM Q1D C29 H39 B N2 O9 S B(c1ccc(cc....
545 2PSU Ki = 24 nM MUU C26 H35 N3 O6 S CNC(=O)CCC....
546 4K4P - 3TL C50 H64 N6 O10 C[C@@H](C(....
547 2AID Ki = 15 uM THK C23 H27 Cl F N O S2 c1cc(ccc1C....
548 5AH7 - C7J C27 H36 Cl N3 O7 S CC(C)CN(CC....
549 3GGA - GGW C39 H53 N5 O7 CC(C)(C)[C....
550 6OXX - NF7 C29 H40 N2 O9 S CC(C)CN(C[....
551 3BXR Ki = 0.8 uM DRR C37 H51 N5 O7 CC[C@H](C)....
552 1KJF - ARG PRO GLY ASN PHE LEU GLN SER ARG PRO n/a n/a
553 1SBG Ki = 18 nM IM1 C31 H42 N4 O4 CC(C)[C@@H....
554 2NMZ - ROC C38 H50 N6 O5 CC(C)(C)NC....
555 3DJK Ki = 26 pM G55 C27 H38 N2 O8 S CC(C)C[N@@....
556 4DFG Ki = 1.8 pM 0JV C31 H43 N3 O9 S CC(C)CN(C[....
557 1EC2 Ki = 0.1 nM BEJ C42 H52 N6 O8 CC(C)[C@@H....
558 1YTH - ACE SER LEU ASN PHE n/a n/a
559 3HDK Kd = 17.5 uM 2NC C35 H68 N11 O8 CCCC[C@@H]....
560 4M8Y Ki = 0.11 nM KGQ C33 H49 N2 O12 P S CCOP(=O)(C....
561 2RKF Ki = 0.83 nM AB1 C37 H48 N4 O5 Cc1cccc(c1....
562 3IAW Kd = 1.57 uM 2NC C35 H68 N11 O8 CCCC[C@@H]....
563 3NXE - 2NC C35 H68 N11 O8 CCCC[C@@H]....
564 3FSM Kd = 100 nM 2NC C35 H68 N11 O8 CCCC[C@@H]....
565 4EP2 Kd = 4.43 uM ALA GLU THR PHE TYR VAL ASP GLY n/a n/a
566 4NPT - 017 C27 H37 N3 O7 S CC(C)C[N@@....
567 6OGQ ic50 = 26 nM JDV C33 H41 F N4 O7 S2 CC(C)CN(C[....
568 6OGT ic50 = 31 nM JDY C33 H41 F N4 O7 S2 CC(C)CN(C[....
569 4YHQ Ki = 1.7 nM G10 C27 H35 F2 N3 O7 S CC(C)CN(C[....
570 6PRF Ki = 2.5 nM 7OA C33 H40 F2 N4 O7 S2 CC(C)CN(C[....
571 4YE3 Ki = 4.3 nM G04 C29 H40 N2 O9 S CC(C)C[N@@....
572 4J5J Ka = 5610000 M^-1 478 C25 H35 N3 O6 S CC(C)C[N@]....
573 3UFN Kd = 930 nM ROC C38 H50 N6 O5 CC(C)(C)NC....
574 4J54 - G52 C30 H40 N2 O9 S CC(C)C[N@@....
575 3UCB Kd = 41 nM 017 C27 H37 N3 O7 S CC(C)C[N@@....
576 3UHL - 2NC C35 H68 N11 O8 CCCC[C@@H]....
577 1BDQ Ki = 460 nM IM1 C31 H42 N4 O4 CC(C)[C@@H....
578 4EP3 - LYS ALA ARG VAL LEU ALA GLU ALA MET n/a n/a
579 3KA2 Kd = 0.24 uM 2NC C35 H68 N11 O8 CCCC[C@@H]....
580 3HLO Kd = 0.61 uM 2NC C35 H68 N11 O8 CCCC[C@@H]....
581 4EPJ - ALA THR ILE MET MET GLN ARG GLY n/a n/a
582 1HVC - A79 C44 H58 N8 O6 CC(C)[C@@H....
583 2WHH - PPN C9 H10 N2 O4 c1cc(ccc1C....
584 3N3I - ROC C38 H50 N6 O5 CC(C)(C)NC....
585 4EQJ Kd = 2.52 uM ALA GLU THR PHE TYR VAL ASP GLY n/a n/a
586 4NJS - G08 C28 H37 N3 O8 S CC(C)CN(C[....
587 4NJT - 017 C27 H37 N3 O7 S CC(C)C[N@@....
588 4NJU - TPV C31 H33 F3 N2 O5 S CCC[C@]1(C....
589 4NJV - RIT C37 H48 N6 O5 S2 CC(C)c1nc(....
590 6O57 Ki = 514 nM 2NC C35 H68 N11 O8 CCCC[C@@H]....
591 5T2Z - 017 C27 H37 N3 O7 S CC(C)C[N@@....
592 6O5X Ki = 22 nM 0Q4 C40 H70 N11 O8 CCCC[C@@H]....
593 6O5A Ki = 514 nM 2NC C35 H68 N11 O8 CCCC[C@@H]....
594 3DOX - SER GLN ASN TYR n/a n/a
595 4Q5M - ROC C38 H50 N6 O5 CC(C)(C)NC....
596 3U7S Ki = 3700 pM 017 C27 H37 N3 O7 S CC(C)C[N@@....
597 3GGU Ki = 170 pM 017 C27 H37 N3 O7 S CC(C)C[N@@....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: ROC; Similar ligands found: 5
No: Ligand ECFP6 Tc MDL keys Tc
1 ROC 1 1
2 0PO 0.527397 0.892308
3 QNC ASN HPH DIQ NTB 0.486111 0.96875
4 1UN 0.440298 0.826087
5 0PP 0.415493 0.787879
Similar Ligands (3D)
Ligand no: 1; Ligand: ROC; Similar ligands found: 1
No: Ligand Similarity coefficient
1 RO1 0.9326
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4Q5M; Ligand: ROC; Similar sites found with APoc: 1
This union binding pocket(no: 1) in the query (biounit: 4q5m.bio1) has 32 residues
No: Leader PDB Ligand Sequence Similarity
1 1BAI 0Q4 40.3226
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