Receptor
PDB id Resolution Class Description Source Keywords
4PSB 1.42 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF PHYTOHORMONE BINDING PROTEIN FROM VIGNA IN COMPLEX WITH GIBBERELLIC ACID (GA3) VIGNA RADIATA CYTOKININ SPECIFIC BINDING PROTEIN (CSBP) PR-10 FOLD GIBBECYTOKININ PLANT HORMONE BINDING PLANT PROTEIN
Ref.: SPECIFIC BINDING OF GIBBERELLIC ACID BY CYTOKININ-S BINDING PROTEINS: A NEW ASPECT OF PLANT HORMONE-BIN PROTEINS WITH THE PR-10 FOLD. ACTA CRYSTALLOGR.,SECT.D V. 70 2032 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GA3 A:201;
Valid;
none;
Kd = 23 uM
346.374 C19 H22 O6 C[C@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4PSB 1.42 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF PHYTOHORMONE BINDING PROTEIN FROM VIGNA IN COMPLEX WITH GIBBERELLIC ACID (GA3) VIGNA RADIATA CYTOKININ SPECIFIC BINDING PROTEIN (CSBP) PR-10 FOLD GIBBECYTOKININ PLANT HORMONE BINDING PLANT PROTEIN
Ref.: SPECIFIC BINDING OF GIBBERELLIC ACID BY CYTOKININ-S BINDING PROTEINS: A NEW ASPECT OF PLANT HORMONE-BIN PROTEINS WITH THE PR-10 FOLD. ACTA CRYSTALLOGR.,SECT.D V. 70 2032 2014
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 473 families.
1 3C0V - ZEA C10 H13 N5 O C/C(=CCNc1....
2 2FLH Kd = 148 uM ZEA C10 H13 N5 O C/C(=CCNc1....
3 4PSB Kd = 23 uM GA3 C19 H22 O6 C[C@@]12[C....
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 355 families.
1 3C0V - ZEA C10 H13 N5 O C/C(=CCNc1....
2 2FLH Kd = 148 uM ZEA C10 H13 N5 O C/C(=CCNc1....
3 4PSB Kd = 23 uM GA3 C19 H22 O6 C[C@@]12[C....
4 4Q0K Kd = 13.4 uM GA3 C19 H22 O6 C[C@@]12[C....
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 272 families.
1 3C0V - ZEA C10 H13 N5 O C/C(=CCNc1....
2 2FLH Kd = 148 uM ZEA C10 H13 N5 O C/C(=CCNc1....
3 4PSB Kd = 23 uM GA3 C19 H22 O6 C[C@@]12[C....
4 4Q0K Kd = 13.4 uM GA3 C19 H22 O6 C[C@@]12[C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GA3; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 GA3 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4PSB; Ligand: GA3; Similar sites found: 124
This union binding pocket(no: 1) in the query (biounit: 4psb.bio1) has 34 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5N1X 8HH 0.01243 0.45987 None
2 5FPX GLY SER SER HIS HIS HIS HIS HIS 0.001696 0.44765 None
3 5AIG VPR 0.007631 0.43677 None
4 1OGZ EQU 0.007448 0.43305 None
5 4ZU4 4TG 0.003833 0.43145 None
6 1SN0 T44 0.008848 0.42932 None
7 3BRN SRO 0.02013 0.42431 None
8 2AGC DAO 0.01733 0.42257 None
9 5EPQ OLA 0.01603 0.40932 None
10 4RW3 IPD 0.03162 0.40878 None
11 2BOS GLA GAL GLC 0.009378 0.40708 None
12 1SDW IYT 0.025 0.40669 None
13 1FMB HYB 0.0328 0.40073 None
14 3A51 VDY 0.02469 0.40028 None
15 3M3E GAL A2G NPO 0.01561 0.42444 1.29032
16 5OO5 UUA 0.007779 0.42435 1.6129
17 1X8D RNS 0.04115 0.40703 1.92308
18 1I06 TZL 0.0009376 0.49493 1.93548
19 1DZK PRZ 0.004067 0.4378 1.93548
20 4FHT DHB 0.02218 0.42381 1.93548
21 2ET1 GLV 0.03675 0.41112 1.93548
22 2CM4 RCL 0.003803 0.42472 2
23 5KEW 6SB 0.01043 0.44145 2.08333
24 4L4J NAG NAG BMA MAN NAG 0.004055 0.44587 2.58065
25 3K3K A8S 0.0001038 0.49817 3.22581
26 4WVO 3UZ 0.00008987 0.4751 3.22581
27 2OVD DAO 0.006775 0.44829 3.22581
28 4D1J DGJ 0.01785 0.42498 3.22581
29 3TL1 JRO 0.02586 0.41751 3.22581
30 3N9P OGA 0.0364 0.4116 3.22581
31 2YJD YJD 0.01753 0.40744 3.22581
32 1U3R 338 0.01935 0.4022 3.22581
33 4AZC NGW 0.04025 0.40187 3.22581
34 5HA0 LTD 0.007575 0.40031 3.22581
35 4U0W 16G 0.009235 0.41728 3.87097
36 5U83 ZN8 0.02738 0.41617 3.87097
37 4P7X YCP 0.01091 0.41389 3.87097
38 2P1E LAC 0.03191 0.4108 3.87097
39 4QCK ASD 0.01922 0.40888 3.87097
40 4XT2 43L 0.006747 0.41073 4.2735
41 2WA4 069 0.005655 0.43903 4.51613
42 1UMZ BGC BGC XYS BGC XYS GAL 0.01863 0.42093 4.51613
43 5X7Q GLC GLC GLC GLC GLC 0.03203 0.41386 4.51613
44 5X7Q GLC GLC GLC GLC 0.03487 0.41182 4.51613
45 4KYS VIB 0.03438 0.4108 4.51613
46 4CJN QNZ 0.03859 0.41051 4.51613
47 5DZT AMP 0.03472 0.41007 4.51613
48 2OVW CBI 0.046 0.40389 4.51613
49 4A69 I0P 0.04893 0.40242 4.51613
50 1I9Z 2IP 0.01544 0.42578 5.16129
51 4TV1 36M 0.02102 0.42239 5.16129
52 3UU7 2OH 0.02609 0.41653 5.16129
53 4MG8 27J 0.01738 0.41102 5.16129
54 2R5A MLZ 0.02015 0.4097 5.16129
55 4TUZ 36J 0.02365 0.4079 5.16129
56 4MGD 27N 0.02352 0.40457 5.16129
57 1OGX EQU 0.00487 0.43806 5.34351
58 4IAW LIZ 0.01808 0.41756 5.80645
59 2XMY CDK 0.004801 0.41471 5.80645
60 5GNX BGC 0.04794 0.40348 5.80645
61 1ZB6 GST 0.004417 0.40205 5.80645
62 5MN0 A8S 0.002013 0.45237 6.45161
63 5MOB A8S 0.005099 0.44572 6.45161
64 2HZQ STR 0.02311 0.42131 6.45161
65 4XBT 3ZQ 0.008094 0.41997 6.45161
66 4XBT FLC 0.009698 0.41629 6.45161
67 2VFT SOR 0.03042 0.40591 6.45161
68 3SI2 PBD 0.0302 0.40254 6.45161
69 1GT4 UNA 0.02399 0.40089 6.45161
70 5ISY NAD 0.009458 0.42787 7.09677
71 5I8T LAC 0.02508 0.41823 7.09677
72 4B1L FRU 0.02489 0.4101 7.09677
73 2YG2 S1P 0.008076 0.40735 7.09677
74 4ZXA H8N 0.01577 0.42473 7.74194
75 2QL9 CIT 0.02443 0.41753 7.74194
76 3N29 NSD 0.02526 0.41665 7.74194
77 3FW9 SLX 0.01204 0.40866 7.74194
78 4FFG LBS 0.008688 0.40761 7.74194
79 1QY1 PRZ 0.01012 0.40597 7.74194
80 1I82 BGC BGC 0.004271 0.4623 8.3871
81 3GM5 CIT 0.009711 0.44031 8.3871
82 4COQ SAN 0.011 0.43979 8.3871
83 4XCB AKG 0.0447 0.40457 8.3871
84 5NGL NOJ BGC 0.04499 0.40063 9.03226
85 1M6P M6P 0.009384 0.44128 9.21053
86 4H69 10Y 0.004603 0.43925 10.3093
87 2R5V HHH 0.02127 0.41022 10.3226
88 5U9J GER 0.03954 0.40748 10.3226
89 1U0A BGC BGC BGC BGC 0.01887 0.40591 10.3226
90 1DJX I3P 0.0317 0.40499 10.3226
91 4OCT AKG 0.03354 0.40371 10.3226
92 4AZT LY2 0.008639 0.43401 10.9677
93 4H6B 10Y 0.002367 0.46273 11.6129
94 4H6B 10X 0.004139 0.45519 11.6129
95 4X5S AZM 0.01548 0.431 12.2581
96 2IF8 ADP 0.01918 0.42454 12.2581
97 4J8T DOG 0.03346 0.40029 13.1387
98 1LFO OLA 0.0147 0.40467 13.2812
99 1I7M PUT 0.01614 0.40931 13.4328
100 3DZ6 PUT 0.03164 0.40082 13.4328
101 3KFF ZBT 0.01196 0.43561 13.5484
102 3KFF XBT 0.01196 0.43561 13.5484
103 4BXF AKG 0.04776 0.40456 13.5484
104 5BVB DOG 0.01872 0.40607 13.6364
105 5W0N UPU 0.01873 0.4251 14.1935
106 4DA5 0H7 0.04195 0.4039 16.129
107 2Q4X HMH 0.03028 0.41824 16.7742
108 4MJ0 BGC SIA SIA GAL 0.04042 0.40782 16.7742
109 2F2G HMH 0.04491 0.40649 16.7742
110 5NCF 8T5 0.02238 0.42092 16.8142
111 4H2X G5A 0.01724 0.40149 17.4757
112 3JRS A8S 0.0002029 0.40401 19.7115
113 5VNF VAL THR SER VAL VAL 0.0266 0.41276 20
114 3KDJ A8S 0.0003769 0.47751 20.7921
115 5I8F ML1 0.000818 0.48625 21.2903
116 4REI 3MV 0.01425 0.4314 22.5166
117 4LA7 A1O 0.0001037 0.48047 22.5806
118 4OIC A8S 0.01501 0.41069 27.7419
119 3OJI PYV 0.001747 0.44324 30.3226
120 4DS8 A8S 0.01527 0.41379 30.3226
121 4JHG ZEA 0.005178 0.4328 32.9032
122 4MA6 28E 0.00003046 0.57461 38.7097
123 4RYV ZEA 0.02945 0.40664 41.2903
124 4MNS 2AX 0.00002759 0.41725 47.7419
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