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Receptor
PDB id Resolution Class Description Source Keywords
4OBW 2.4 Å EC: 2.1.1.201 CRYSTAL STRUCTURE OF YEAST COQ5 IN THE SAM BOUND FORM SACCHAROMYCES CEREVISIAE ROSSMANN FOLD METHYLTRANSFERASE TRANSFERASE
Ref.: CRYSTAL STRUCTURES AND CATALYTIC MECHANISM OF THE C-METHYLTRANSFERASE COQ5 PROVIDE INSIGHTS INTO A KE THE YEAST COENZYME Q SYNTHESIS PATHWAY. ACTA CRYSTALLOGR.,SECT.D V. 70 2085 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SAM D:601;
A:602;
C:601;
B:601;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
398.437 C15 H22 N6 O5 S C[S@@...
TAM A:601;
D:602;
Invalid;
Invalid;
none;
none;
submit data
163.215 C7 H17 N O3 C(CO)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4OBW 2.4 Å EC: 2.1.1.201 CRYSTAL STRUCTURE OF YEAST COQ5 IN THE SAM BOUND FORM SACCHAROMYCES CEREVISIAE ROSSMANN FOLD METHYLTRANSFERASE TRANSFERASE
Ref.: CRYSTAL STRUCTURES AND CATALYTIC MECHANISM OF THE C-METHYLTRANSFERASE COQ5 PROVIDE INSIGHTS INTO A KE THE YEAST COENZYME Q SYNTHESIS PATHWAY. ACTA CRYSTALLOGR.,SECT.D V. 70 2085 2014
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4OBW - SAM C15 H22 N6 O5 S C[S@@+](CC....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4OBW - SAM C15 H22 N6 O5 S C[S@@+](CC....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4OBW - SAM C15 H22 N6 O5 S C[S@@+](CC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAM; Similar ligands found: 202
No: Ligand ECFP6 Tc MDL keys Tc
1 SAM 1 1
2 SMM 0.792683 0.96
3 S4M 0.6875 0.909091
4 S7M 0.670455 0.945946
5 M2T 0.636364 0.878378
6 GEK 0.612903 0.931507
7 SAI 0.571429 0.878378
8 ADN 0.565789 0.773333
9 RAB 0.565789 0.773333
10 XYA 0.565789 0.773333
11 5CD 0.564103 0.783784
12 EP4 0.5625 0.826667
13 SA8 0.56044 0.945205
14 SFG 0.555556 0.875
15 5X8 0.555556 0.888889
16 5N5 0.551282 0.773333
17 A4D 0.544304 0.797297
18 EEM 0.542553 0.945946
19 SAH 0.537634 0.916667
20 DTA 0.536585 0.789474
21 62X 0.535354 0.884615
22 MTA 0.53012 0.875
23 3DH 0.517647 0.849315
24 5AL 0.510417 0.743902
25 54H 0.510204 0.673913
26 VMS 0.510204 0.673913
27 0UM 0.51 0.857143
28 AMP 0.505747 0.707317
29 LMS 0.505747 0.666667
30 A 0.505747 0.707317
31 ABM 0.505618 0.753086
32 A5A 0.505155 0.688889
33 SON 0.5 0.746988
34 SSA 0.5 0.684783
35 6RE 0.5 0.78481
36 K15 0.5 0.883117
37 5AD 0.5 0.75
38 SRP 0.5 0.746988
39 LSS 0.49505 0.706522
40 CA0 0.494624 0.714286
41 A12 0.494505 0.705882
42 AP2 0.494505 0.705882
43 ME8 0.490385 0.841463
44 TSB 0.49 0.681319
45 53H 0.49 0.666667
46 DAL AMP 0.49 0.765432
47 5CA 0.49 0.684783
48 ACP 0.489362 0.694118
49 ADP 0.48913 0.690476
50 5AS 0.48913 0.648936
51 J7C 0.488889 0.772152
52 A2D 0.488889 0.690476
53 ZAS 0.488636 0.769231
54 9ZD 0.485149 0.729412
55 9ZA 0.485149 0.729412
56 8QN 0.485149 0.743902
57 GAP 0.484536 0.73494
58 AN2 0.483871 0.682353
59 A3S 0.483871 0.813333
60 A7D 0.483871 0.851351
61 GJV 0.483516 0.775
62 SRA 0.483146 0.694118
63 LAD 0.480769 0.752941
64 KAA 0.480769 0.698925
65 GSU 0.480769 0.722222
66 AMO 0.480392 0.746988
67 DSZ 0.480392 0.703297
68 52H 0.48 0.666667
69 M33 0.478723 0.722892
70 BA3 0.478261 0.690476
71 MAO 0.478261 0.82716
72 NEC 0.477778 0.75
73 AOC 0.477778 0.776316
74 DSH 0.477778 0.842105
75 SXZ 0.47619 0.894737
76 AHX 0.475728 0.701149
77 NVA LMS 0.475728 0.736264
78 Y3J 0.47561 0.706667
79 G5A 0.474227 0.684783
80 A3T 0.473684 0.8
81 B4P 0.473118 0.690476
82 AP5 0.473118 0.690476
83 A3N 0.472527 0.766234
84 KB1 0.471698 0.833333
85 PRX 0.46875 0.73494
86 APC 0.46875 0.705882
87 AT4 0.468085 0.686047
88 PAJ 0.466019 0.712644
89 4AD 0.466019 0.759036
90 RBY 0.463918 0.72619
91 ADP PO3 0.463918 0.728395
92 ADV 0.463918 0.72619
93 ADX 0.463158 0.666667
94 MHZ 0.463158 0.82716
95 AU1 0.463158 0.674419
96 YAP 0.462963 0.738095
97 TXA 0.462264 0.72619
98 NB8 0.462264 0.72093
99 A3G 0.461538 0.802632
100 VRT 0.459184 0.842105
101 XAH 0.458716 0.715909
102 YSA 0.458716 0.684783
103 HEJ 0.458333 0.690476
104 50T 0.458333 0.682353
105 ATP 0.458333 0.690476
106 LEU LMS 0.457143 0.717391
107 7D7 0.45679 0.723684
108 KH3 0.455357 0.871795
109 ACQ 0.454545 0.694118
110 AR6 0.453608 0.710843
111 APR 0.453608 0.710843
112 AQP 0.453608 0.690476
113 5FA 0.453608 0.690476
114 NSS 0.451923 0.703297
115 FA5 0.449541 0.746988
116 A5D 0.44898 0.789474
117 AD9 0.44898 0.674419
118 AGS 0.44898 0.678161
119 SAP 0.44898 0.678161
120 PTJ 0.448598 0.72093
121 YLB 0.448276 0.758621
122 YLP 0.447368 0.738636
123 8X1 0.446602 0.680851
124 D3Y 0.446602 0.792208
125 ADP ALF 0.445545 0.678161
126 ALF ADP 0.445545 0.678161
127 3AM 0.444444 0.674699
128 MYR AMP 0.444444 0.776471
129 OAD 0.443396 0.73494
130 2VA 0.443299 0.779221
131 S8M 0.442308 0.831169
132 OOB 0.442308 0.722892
133 TYR AMP 0.441441 0.759036
134 6YZ 0.441176 0.694118
135 ADP VO4 0.441176 0.702381
136 VO4 ADP 0.441176 0.702381
137 T99 0.44 0.686047
138 TAT 0.44 0.686047
139 ANP 0.44 0.674419
140 WAQ 0.439252 0.75
141 B5Y 0.436364 0.717647
142 8PZ 0.436364 0.684783
143 F0P 0.435897 0.844156
144 YLC 0.435897 0.755814
145 AAT 0.435644 0.797468
146 1ZZ 0.435185 0.755814
147 9K8 0.435185 0.663158
148 3OD 0.435185 0.73494
149 NVA 2AD 0.434343 0.855263
150 00A 0.433962 0.689655
151 DLL 0.433962 0.722892
152 ARG AMP 0.433628 0.727273
153 7MD 0.433628 0.715909
154 ATF 0.431373 0.666667
155 SO8 0.43 0.792208
156 3UK 0.429907 0.714286
157 A6D 0.429907 0.72619
158 9X8 0.429907 0.717647
159 F2R 0.429752 0.7
160 5SV 0.428571 0.741176
161 AMP DBH 0.428571 0.714286
162 TYM 0.42735 0.746988
163 WSA 0.42735 0.692308
164 9SN 0.427273 0.681818
165 AHZ 0.426087 0.755814
166 P5A 0.425926 0.691489
167 B5V 0.425926 0.705882
168 PR8 0.425926 0.744186
169 A A 0.425926 0.710843
170 3NZ 0.425926 0.807692
171 A1R 0.424528 0.709302
172 2A5 0.424242 0.674419
173 7MC 0.423729 0.719101
174 B5M 0.423423 0.717647
175 7D5 0.422222 0.658824
176 JB6 0.422018 0.709302
177 FYA 0.422018 0.722892
178 AYB 0.421488 0.75
179 A22 0.419048 0.682353
180 MAP 0.419048 0.659091
181 2AM 0.417582 0.666667
182 TAD 0.417391 0.712644
183 A3P 0.416667 0.686747
184 ADP BMA 0.416667 0.714286
185 25A 0.415094 0.690476
186 YLA 0.413223 0.719101
187 8Q2 0.411765 0.663158
188 A3R 0.411215 0.709302
189 ADQ 0.411215 0.694118
190 48N 0.410256 0.72093
191 0XU 0.41 0.824324
192 GA7 0.408696 0.72619
193 7D3 0.40625 0.643678
194 PAP 0.405941 0.678571
195 DQV 0.405172 0.702381
196 OVE 0.404255 0.662791
197 4UV 0.403509 0.697674
198 AF3 ADP 3PG 0.403361 0.712644
199 3AD 0.402299 0.783784
200 CMP 0.402062 0.691358
201 2BA 0.402062 0.682927
202 7C5 0.4 0.731707
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4OBW; Ligand: SAM; Similar sites found with APoc: 765
This union binding pocket(no: 1) in the query (biounit: 4obw.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 1U7T TDT None
2 4CS9 AMP None
3 5J5Z FAD 1.16732
4 1H5Q NAP 1.16732
5 3A28 NAD 1.16732
6 4ZCC NAI 1.55642
7 4ZCC FAD 1.55642
8 3U4C NDP 1.55642
9 4EIP FAD 1.55642
10 1X7D ORN 1.55642
11 1X7D NAD 1.55642
12 1KYQ NAD 1.55642
13 1QAN SAH 1.63934
14 3DUW SAH 1.79372
15 3OU2 SAH 1.83486
16 2CDU FAD 1.94553
17 3BGD PM6 1.94553
18 4HA6 FAD 1.94553
19 3BGD SAH 1.94553
20 3CH6 NAP 1.94553
21 3CH6 311 1.94553
22 6EL3 NAP 1.94553
23 6FHO FAD 1.94553
24 2CDU ADP 1.94553
25 5KOX FAD 1.94553
26 5KOX RFP 1.94553
27 5K0A FAD 1.94553
28 4K5S PM0 1.94553
29 4K5S FAD 1.94553
30 3AFN NAP 1.94553
31 6FP4 FAD 1.94553
32 6FP4 E1T 1.94553
33 4Q9N NAI 1.94553
34 1GEG NAD 1.95312
35 1XTP SAI 1.9685
36 1PR9 NAP 2.04918
37 3D3W NAP 2.04918
38 5YU3 PRO 2.32558
39 5YU3 NAD 2.32558
40 4AZW SAM 2.33463
41 3T7S SAM 2.33463
42 2EFJ SAH 2.33463
43 3C6K SPD 2.33463
44 3C6K MTA 2.33463
45 6C5B SAH 2.33463
46 1ZQ9 SAM 2.33463
47 4DMG SAM 2.33463
48 1BC5 SAH 2.33463
49 3GD4 FAD 2.33463
50 3GD4 NAD 2.33463
51 5XLX SAH 2.33463
52 2GDZ NAD 2.33463
53 5JCM ISD 2.33463
54 5JCM NAD 2.33463
55 5JCM FAD 2.33463
56 5FJN BE2 2.33463
57 5FJN FAD 2.33463
58 6F97 FAD 2.33463
59 4NTC FAD 2.33463
60 4CNK FAD 2.33463
61 4FC7 COA 2.33463
62 4FC7 NAP 2.33463
63 2G5C NAD 2.33463
64 5JAQ NAI 2.33463
65 1XG5 NAP 2.33463
66 3UOY NAP 2.33463
67 3UOY FAD 2.33463
68 5EB4 FAD 2.33463
69 3QWI NAP 2.33463
70 3QWI CUE 2.33463
71 4J36 FAD 2.33463
72 3A4V PYR 2.33463
73 3A4V NAD 2.33463
74 4J36 1HR 2.33463
75 2BRY FAD 2.33463
76 2Y6Q I7T 2.33463
77 2Y6Q FAD 2.33463
78 4TXI FAD 2.33463
79 3O7W SAM 2.38095
80 2XVM SAH 2.51256
81 2BZ1 TAU 2.55102
82 5LOG SAH 2.57511
83 3CBG SAH 2.58621
84 6DUB SAH 2.7027
85 1Z3C SA8 2.72374
86 1G60 SAM 2.72374
87 3X0D SAH 2.72374
88 3A25 SAM 2.72374
89 4YAC NAI 2.72374
90 5ICE 2H4 2.72374
91 5ICE SAH 2.72374
92 5ULP KB1 2.72374
93 4ITU NAI 2.72374
94 4ITU 1HS 2.72374
95 5G3U FDA 2.72374
96 5G3U ITW 2.72374
97 5Z75 NAD 2.72374
98 2Q7V FAD 2.72374
99 5I39 FAD 2.72374
100 4JNA FAD 2.72374
101 3RKR NAP 2.72374
102 4TM3 FAD 2.72374
103 1BW9 NAD 2.72374
104 1PS9 FAD 2.72374
105 1H82 GZZ 2.72374
106 1H82 FAD 2.72374
107 2V6G NAP 2.72374
108 4EMI NAD 2.72374
109 4EMI FAD 2.72374
110 5GSN FAD 2.72374
111 5GSN NAP 2.72374
112 3K7M FAD 2.72374
113 5GSN MMZ 2.72374
114 5EZ7 FAD 2.72374
115 5D4V SAH 2.72374
116 1E5Q NDP 2.72374
117 4U8P UDP 2.72374
118 5ZBC FAD 2.72374
119 4U8P FDA 2.72374
120 2RH4 EMO 2.72374
121 1Q8O MAN MMA 2.77778
122 2GMM MAN MAN 2.77778
123 5Z2L NDP 2.85714
124 2BD0 NAP 2.86885
125 4NBT NAD 2.91667
126 3H2B SAH 2.95567
127 6AIN FAD 3.11005
128 4M73 M72 3.11284
129 4M73 SAH 3.11284
130 4KIB SAH 3.11284
131 1KPH SAH 3.11284
132 2FK8 SAM 3.11284
133 1KPG SAH 3.11284
134 3P9C SAH 3.11284
135 3VYW SAM 3.11284
136 3AYI FAD 3.11284
137 3AYI HCI 3.11284
138 5BJX NAD 3.11284
139 5BJX UDP 3.11284
140 3EVG SAH 3.11284
141 4RSL FAD 3.11284
142 3GF4 FAD 3.11284
143 1XHC FAD 3.11284
144 1ZBQ NAD 3.11284
145 6F9Q NAD 3.11284
146 3GF4 UPG 3.11284
147 1VL8 NAP 3.11284
148 4FWE FAD 3.11284
149 6F7L FAD 3.11284
150 3MCT SAH 3.11284
151 1YXM ADE 3.11284
152 1E1M NAP 3.11284
153 1E1M FAD 3.11284
154 2FR1 NDP 3.11284
155 3MAG SAH 3.11284
156 1LDN NAD 3.11284
157 1G0N NDP 3.11284
158 1G0N PHH 3.11284
159 2NVK FAD 3.11284
160 1FL2 FAD 3.11284
161 3CTY FAD 3.11284
162 3GMB FAD 3.11284
163 3OID NDP 3.11284
164 5K4W THR 3.11284
165 3WLE NAD 3.11284
166 5K4W NAI 3.11284
167 4D42 NAP 3.11284
168 4D42 W0I 3.11284
169 1GZ6 NAI 3.1348
170 3DXY SAM 3.21101
171 2EWM NAD 3.21285
172 4IV9 FAD 3.2316
173 3GEG NAD 3.23887
174 3I53 SAH 3.31325
175 2HNK SAH 3.34728
176 3G2O SAM 3.50195
177 3GDH SAH 3.50195
178 3NDJ JHZ 3.50195
179 3NDJ SAH 3.50195
180 2ZIF SAM 3.50195
181 4N49 SAM 3.50195
182 1RJD SAM 3.50195
183 6ARJ BW4 3.50195
184 3A27 SAM 3.50195
185 1KYZ SAH 3.50195
186 6ARJ SAH 3.50195
187 1FP2 SAH 3.50195
188 2Z3Y F2N 3.50195
189 5DX8 SFG 3.50195
190 5JJR SAH 3.50195
191 5EJ2 NAD 3.50195
192 2GV8 FAD 3.50195
193 1FP2 HMO 3.50195
194 1VQW FAD 3.50195
195 2GVC FAD 3.50195
196 1NAA 6FA 3.50195
197 1NAA ABL 3.50195
198 1KYZ FER 3.50195
199 5DXA SFG 3.50195
200 5DX1 SFG 3.50195
201 6H3O FAD 3.50195
202 5DWQ SFG 3.50195
203 5DX0 SFG 3.50195
204 5TUF TDC 3.50195
205 3V1U NAD 3.50195
206 5TUF FAD 3.50195
207 1R18 SAH 3.52423
208 5ZW3 SAH 3.55556
209 2JAH NDP 3.64372
210 1UAY ADN 3.71901
211 5FA8 SAM 3.72671
212 2EG5 SAH 3.89105
213 3VC1 GST 3.89105
214 3VC1 SAH 3.89105
215 5KOK SAH 3.89105
216 6GKV SAH 3.89105
217 5KOK S9T 3.89105
218 5KOK R9T 3.89105
219 4E70 N7I 3.89105
220 4DCM SAM 3.89105
221 4RPL 3UC 3.89105
222 4RPL FAD 3.89105
223 1Y8Q ATP 3.89105
224 1YQZ FAD 3.89105
225 4LWP SAH 3.89105
226 4OPC FDA 3.89105
227 4OPC PGT 3.89105
228 3EYA FAD 3.89105
229 1RSG FAD 3.89105
230 1F3L SAH 3.89105
231 1YY5 FAD 3.89105
232 5KMS NAD 3.89105
233 5J60 FAD 3.89105
234 4HXY NDP 3.89105
235 2E5V FAD 3.89105
236 1LVL NAD 3.89105
237 1LTH NAD 3.89105
238 4NTD FAD 3.89105
239 1UP7 NAD 3.89105
240 1OBB NAD 3.89105
241 1LVL FAD 3.89105
242 1SOW NAD 3.89105
243 3WDM ADN 3.89105
244 5N0J FAD 3.89105
245 5KMS FAD 3.89105
246 3TN7 NJP 3.89105
247 3HVJ 705 4.0724
248 3JWH SAH 4.14747
249 2VT3 ATP 4.18605
250 3GRU AMP 4.28016
251 1ELI PYC 4.28016
252 5FWA J7C 4.28016
253 2AE2 PTO 4.28016
254 2AE2 NAP 4.28016
255 4MOP 2H5 4.28016
256 1I8T FAD 4.28016
257 1E6W NAD 4.28016
258 1G8K MGD 4.28016
259 5TS5 FAD 4.28016
260 1E3W NAD 4.28016
261 4YRY NAD 4.28016
262 4YRY FAD 4.28016
263 4M52 FAD 4.28016
264 1P77 ATR 4.28016
265 3IHG FAD 4.28016
266 4REP FAD 4.28016
267 4O1M NAD 4.28016
268 5MZI FYK 4.28016
269 5MZI FAD 4.28016
270 4XQC 13D 4.28016
271 4XQC NAD 4.28016
272 4UCI SAM 4.28016
273 1V6A TRE 4.28016
274 2YG3 FAD 4.28016
275 1ZK7 FAD 4.28266
276 3RJ5 NAD 4.33071
277 3EGI ADP 4.36893
278 4URF NAD 4.43548
279 5T2U NAP 4.43548
280 2AG5 NAD 4.47154
281 4RDH AMP 4.51389
282 4RDI ATP 4.51389
283 5MW4 5JU 4.66926
284 3QOX SAH 4.66926
285 3LST SAH 4.66926
286 2JJQ SAH 4.66926
287 4BLW AMP 4.66926
288 4KGD TDP 4.66926
289 1FP1 SAH 4.66926
290 4KGD FAD 4.66926
291 5O42 9JW 4.66926
292 5O42 BGC 4.66926
293 5O42 NAD 4.66926
294 2JHP SAH 4.66926
295 1V5F TPP 4.66926
296 1V5F FAD 4.66926
297 1QO8 FAD 4.66926
298 6CI9 NAP 4.66926
299 5O4J 9KH 4.66926
300 3LZW FAD 4.66926
301 1REO FAD 4.66926
302 5O4J SAH 4.66926
303 4L2I FAD 4.66926
304 5O4J PJL 4.66926
305 2WPF FAD 4.66926
306 2V3V MGD 4.66926
307 1Q1R FAD 4.66926
308 5OC1 FAD 4.66926
309 3FXU TSU 4.66926
310 3QFA FAD 4.66926
311 2WPF WPF 4.66926
312 3S5W FAD 4.66926
313 1C0I FAD 4.66926
314 1C0I BE2 4.66926
315 3O03 NAP 4.66926
316 5NMX NAP 4.66926
317 4BLW SAH 4.66926
318 4EMJ FAD 4.6729
319 6C8R EQV 4.74934
320 6C8R SAH 4.74934
321 4YKG NAD 4.79846
322 4YKG FAD 4.79846
323 4OM8 NAD 4.85437
324 2HMT NAI 4.86111
325 5E5U MLI 5.02513
326 3AD8 NAD 5.05051
327 4RVG SAM 5.05837
328 4RVG TYD 5.05837
329 5GWT SIN 5.05837
330 5GWT NAD 5.05837
331 3EVF GTA 5.05837
332 3EVF SAH 5.05837
333 5GWX SAM 5.05837
334 5GWX SAR 5.05837
335 4MO2 FDA 5.05837
336 5BUK FAD 5.05837
337 4MO2 FAD 5.05837
338 1IY8 NAD 5.05837
339 2ZXI FAD 5.05837
340 3SJU NDP 5.05837
341 3GGO NAI 5.05837
342 3GGO ENO 5.05837
343 1OAA OAA 5.05837
344 1DMR PGD 5.05837
345 2VHW NAI 5.05837
346 3LCC SAH 5.10638
347 1XCL SAH 5.10638
348 3RFV 15L 5.24345
349 3RFV NAI 5.24345
350 5YJI SAH 5.44747
351 5YJI 8WO 5.44747
352 1UWK URO 5.44747
353 1UWK NAD 5.44747
354 1NW5 SAM 5.44747
355 3GCZ SAM 5.44747
356 5ERG SAM 5.44747
357 3OND ADN 5.44747
358 3OND NAD 5.44747
359 2RAB NAD 5.44747
360 2HQM FAD 5.44747
361 6F3N ADN 5.44747
362 6F3N NAD 5.44747
363 1RLZ NAD 5.44747
364 6F3M NAD 5.44747
365 2IID FAD 5.44747
366 2IID PHE 5.44747
367 2R4J 13P 5.44747
368 2R4J FAD 5.44747
369 5MLR GRQ 5.44747
370 5MLR NAP 5.44747
371 4C3Y FAD 5.44747
372 4C3Y ANB 5.44747
373 2IXB A2G 5.44747
374 2IXB NAD 5.44747
375 4YDD MGD 5.44747
376 4YDD MD1 5.44747
377 4D7E FAD 5.44747
378 3WMX NAD 5.44747
379 5NA1 FAD 5.44747
380 2Q0L FAD 5.44747
381 1EU1 MGD 5.44747
382 1FUI FOC 5.44747
383 5UR0 NAD 5.44747
384 1BXK NAD 5.44747
385 2DKN NAI 5.4902
386 2WSB NAD 5.51181
387 6GFK SAH 5.57769
388 3NUG NAD 5.66802
389 2O07 SPD 5.83658
390 2O07 MTA 5.83658
391 1X87 NAD 5.83658
392 5CUQ NSC 5.83658
393 5XNC MTA 5.83658
394 2DPM SAM 5.83658
395 2NYA MGD 5.83658
396 5M67 NAD 5.83658
397 5M67 ADE 5.83658
398 5ZYN FAD 5.83658
399 5IL1 SAM 5.83658
400 5YJF 8WO 5.83658
401 1PN0 IPH 5.83658
402 1PN0 FAD 5.83658
403 5K7U SAM 5.83658
404 2IZ1 ATR 5.83658
405 3ZV6 4HB 5.83658
406 3ZV6 NAD 5.83658
407 4J4H NAI 5.83658
408 4J4H 1J1 5.83658
409 5M67 3D1 5.83658
410 5YJF SAH 5.83658
411 4JK3 NAD 5.83658
412 1JA9 NDP 5.83658
413 2CFC NAD 5.83658
414 3C3Y SAH 5.90717
415 1P1C SAH 6.03015
416 4KRG SAH 6.22568
417 6B92 SAH 6.22568
418 4M37 SAH 6.22568
419 4M38 SAH 6.22568
420 3ELW GP3 6.22568
421 3ELW SAM 6.22568
422 2WA2 SAM 6.22568
423 3LCV SAM 6.22568
424 2C31 TZD 6.22568
425 2C31 ADP 6.22568
426 1O97 AMP 6.22568
427 1O97 FAD 6.22568
428 1DL5 SAH 6.22568
429 2C5A GDC 6.22568
430 2C5A NAD 6.22568
431 1U2Z SAH 6.22568
432 4BV6 FAD 6.22568
433 3GDN HBX 6.22568
434 3GDN FAD 6.22568
435 2B4Q NAP 6.22568
436 5TOW ADN 6.22568
437 5TOW NAI 6.22568
438 5X68 FAD 6.22568
439 2YVF FAD 6.22568
440 2YVF NAD 6.22568
441 4Z24 FAD 6.22568
442 4D79 ATP 6.22568
443 1XSE NDP 6.22568
444 2F5Z FAD 6.25
445 2Q2V NAD 6.27451
446 4NBU NAI 6.4
447 4XUC SAM 6.42202
448 4XUC 43G 6.42202
449 1IM8 SAI 6.55738
450 4Y9D NAI 6.55738
451 4C4A SAH 6.61479
452 4NEC SAH 6.61479
453 5FUB SAH 6.61479
454 1I9G SAM 6.61479
455 3DMH SAM 6.61479
456 1ZGA SAH 6.61479
457 3VSE SAH 6.61479
458 3HDY FDA 6.61479
459 3HDY GDU 6.61479
460 3HDY FAD 6.61479
461 1RYI GOA 6.61479
462 1RYI FAD 6.61479
463 3DMH GMP 6.61479
464 2QA1 FAD 6.61479
465 1NFQ NAI 6.61479
466 2VVM FAD 6.61479
467 2VVL FAD 6.61479
468 3P2E SAH 6.66667
469 1EJ0 SAM 6.66667
470 2VDV SAM 6.91057
471 5W7R SAH 6.99301
472 5W7R 9Z7 6.99301
473 6ECU SAH 7.00389
474 6ECW SAH 7.00389
475 5U19 SAH 7.00389
476 5U19 827 7.00389
477 6B3A SAM 7.00389
478 5BW4 SAM 7.00389
479 1OMO NAD 7.00389
480 1XKQ NDP 7.00389
481 5OJI ISN 7.00389
482 5OJI NAP 7.00389
483 4PLT NAI 7.00389
484 2DT5 NAD 7.109
485 5DM1 5D7 7.11611
486 5DM1 SAH 7.11611
487 3NJ4 NAD 7.12644
488 4GKV NAD 7.14286
489 4HSU FAD 7.25806
490 4GUT FAD 7.25806
491 4GUS FAD 7.25806
492 4O0L NDP 7.27273
493 1N2X SAM 7.393
494 6DEN TP9 7.393
495 6DEN FAD 7.393
496 6DEN G8A 7.393
497 6GAR FAD 7.393
498 3ML1 MGD 7.393
499 2NPX FAD 7.393
500 2NPX NAD 7.393
501 3NYC FAD 7.393
502 3NYC IAR 7.393
503 3LKZ SFG 7.393
504 3VPH NAD 7.393
505 3VPH OXM 7.393
506 1Z6Z NAP 7.393
507 1XF1 CIT 7.393
508 5HXI FAD 7.393
509 5KVA SAM 7.393
510 4J7U YTZ 7.393
511 4J7U NAP 7.393
512 3Q9T FAY 7.393
513 4FN4 NAD 7.48031
514 3FZG SAM 7.5
515 5TVI O8N 7.6087
516 5WP4 SAH 7.7821
517 1JQD SAH 7.7821
518 3FPF TNA 7.7821
519 3FPF MTA 7.7821
520 1JQD HSM 7.7821
521 5BVA FAD 7.7821
522 5VN0 NAI 7.7821
523 5VN0 FAD 7.7821
524 3ZNN FAD 7.7821
525 3ZNN 4WL 7.7821
526 4POO SAM 7.7821
527 4X9M FAD 7.7821
528 2IVD FAD 7.7821
529 5FFF NAP 7.7821
530 5U8U FAD 7.7821
531 2IV2 MGD 7.7821
532 5FEU NAP 7.7821
533 1AE1 NAP 7.7821
534 5FFF 5XC 7.7821
535 2UYQ SAM 7.7821
536 1SC6 NAD 7.7821
537 4YMH SAH 7.91667
538 2GAG NAD 8.08081
539 5E9W SAH 8.17121
540 3TKY SAH 8.17121
541 4YNU FAD 8.17121
542 3X0V FAD 8.17121
543 2IVF MGD 8.17121
544 1KOL NAD 8.29146
545 1SQF SAM 8.56031
546 2OBF SAH 8.56031
547 5X62 SAH 8.56031
548 2OBF F83 8.56031
549 3AXB PRO 8.56031
550 3AXB FAD 8.56031
551 4DSG FAD 8.56031
552 4DSG UDP 8.56031
553 3NTD FAD 8.56031
554 3NTA FAD 8.56031
555 1FEC FAD 8.56031
556 1L3I SAH 8.85417
557 5F2K SAH 8.94942
558 5F2K OCA 8.94942
559 1EFV FAD 8.94942
560 1EFV AMP 8.94942
561 3FPZ AHZ 8.94942
562 6GAS FAD 8.94942
563 4TQG NDP 8.94942
564 3AB1 FAD 8.94942
565 2ZJ1 NAD 8.94942
566 2ZJ1 ARJ 8.94942
567 1KQF MGD 8.94942
568 5EYY MDM 8.97959
569 1WY7 SAH 9.17874
570 2AOT SAH 9.33852
571 4X60 SFG 9.33852
572 4X60 3XV 9.33852
573 4GQB 0XU 9.33852
574 5FA5 MTA 9.33852
575 2RGO FAD 9.33852
576 3S1S SAH 9.33852
577 1BDB NAD 9.33852
578 4MP8 MLI 9.33852
579 4MP8 NAD 9.33852
580 2WOX NDP 9.33852
581 1GTE FAD 9.33852
582 3OZ2 FAD 9.33852
583 5DF1 58X 9.33852
584 5DF1 NAP 9.33852
585 3MB5 SAM 9.41177
586 4CQM NAP 9.42623
587 3Q87 SAM 9.6
588 2PX8 SAH 9.66543
589 1V59 FAD 9.72763
590 1V59 NAD 9.72763
591 6ER9 NAP 9.72763
592 6ER9 FAD 9.72763
593 1GET FAD 9.72763
594 1GET NAP 9.72763
595 3SSO SAH 9.72763
596 2PXX SAH 9.76744
597 3FUU ADN 10.1167
598 2Q28 ADP 10.1167
599 3KLJ FAD 10.1167
600 5DNK SAH 10.1167
601 4LHD GLY 10.1167
602 4NBW NAD 10.1167
603 3OFK SAH 10.1852
604 6FDF SAH 10.5058
605 5JE8 NAD 10.5058
606 2WDQ TEO 10.5058
607 2DTX BMA 10.6061
608 5EEH SAH 10.6383
609 5EEH P9P 10.6383
610 3FRH SAH 10.6719
611 1Q0S SAH 10.8108
612 3G89 SAM 10.8434
613 4II2 ATP 10.8434
614 4PIO SAH 10.8949
615 4PIO AVI 10.8949
616 4D5G FAD 10.8949
617 4D5G TPP 10.8949
618 4EUE NAI 10.8949
619 4ONQ SFG 10.8949
620 5ODQ FAD 10.8949
621 5L13 6ZE 10.8949
622 1E6E FAD 10.9375
623 5WP5 SAH 11.284
624 1YBH FAD 11.284
625 5TWB FAD 11.284
626 3WGT FAD 11.284
627 3WGT QSC 11.284
628 5WGR FAD 11.284
629 1T9D P25 11.284
630 1T9D 1MM 11.284
631 1T9D PYD 11.284
632 1RP0 AHZ 11.284
633 5WKC FAD 11.284
634 1NV8 MEQ 11.284
635 1NV8 SAM 11.284
636 1T9D FAD 11.284
637 1MUU NAD 11.284
638 1MV8 NAD 11.284
639 3ICT FAD 11.6732
640 4AP3 NAP 11.6732
641 4AP3 FAD 11.6732
642 3ICR FAD 11.6732
643 3ICS FAD 11.6732
644 2E7Z MGD 11.6732
645 4A6D SAM 12.0623
646 4USR FAD 12.0623
647 2CUL FAD 12.069
648 5BSZ SAH 12.4
649 5F8F SFG 12.4514
650 3PT9 SAH 12.4514
651 1L1E SAH 12.4514
652 4YAG NAI 12.4514
653 5BRT FAD 12.4514
654 5BRT CH9 12.4514
655 2BZG SAH 12.5
656 1XDS SAM 12.8342
657 1TPY SAH 12.8405
658 2YY7 NAD 12.8405
659 1R27 MGD 12.8405
660 1BZL FAD 12.8405
661 1BZL GCG 12.8405
662 3MQ2 SAH 12.844
663 2ZFU SAH 13.0233
664 3GWZ SAH 13.2296
665 3GXO SAH 13.2296
666 2P41 SAH 13.2296
667 2ZWA SAH 13.2296
668 4B63 FAD 13.2296
669 4B63 NAP 13.2296
670 4B63 ORN 13.2296
671 1XHL NDP 13.2296
672 1V8B NAD 13.2296
673 1I1N SAH 13.2743
674 3H8V ATP 13.3562
675 3BXO SAM 13.3891
676 1JG3 ADN 13.617
677 2A14 SAH 13.6187
678 4Y30 49L 13.6187
679 4Y30 SAH 13.6187
680 5E72 SAM 13.6187
681 2DKH FAD 13.6187
682 2DKH 3HB 13.6187
683 4JDR FAD 13.6187
684 2XVE FAD 13.6187
685 2GN4 UD1 13.6187
686 2XVF FAD 13.6187
687 3G5S FAD 13.6187
688 5MIT NAP 13.6187
689 5MIT FAD 13.6187
690 5L95 AMP 13.9785
691 3GU3 SAH 14.0078
692 3TLJ SAH 14.0078
693 6BQ6 TER 14.0078
694 5N5D SAM 14.1593
695 5THY SAH 14.3969
696 1G55 SAH 14.3969
697 5THZ SAH 14.3969
698 5FTW SAH 14.4531
699 4FZV SAM 14.6444
700 5X2N ALA 14.7465
701 1U1I NAD 14.786
702 1NNU TCT 15
703 5GM1 SAH 15.1751
704 5HJM MTA 15.1751
705 4YSX FAD 15.1751
706 5JWC FAD 15.1751
707 5JE0 AZ8 15.3846
708 5JE0 SAH 15.3846
709 3RNM FAD 15.5172
710 1Q9I FAD 15.5642
711 1Q9I TEO 15.5642
712 3A4T SFG 15.9533
713 3M6W SAM 15.9533
714 1LSS NAD 16.4286
715 3ABI NAD 16.7315
716 6CZ7 MGD 16.7315
717 6ECT SAM 17.1206
718 5UFN SAH 17.2269
719 5DLY 5D7 17.5097
720 5DLY SAH 17.5097
721 4USQ FAD 17.5097
722 2YX1 SFG 17.8988
723 2NXE SAM 18.1102
724 3PFG SAM 18.2879
725 3PFG TLO 18.2879
726 2EJU SAH 18.677
727 4PNE SAH 18.677
728 5T67 SAH 18.677
729 5T67 JHZ 18.677
730 2I7C AAT 19.0661
731 2PT9 2MH 19.0661
732 2PT9 S4M 19.0661
733 1WG8 SAM 19.0661
734 1QZZ SAM 19.0661
735 3TKA SAM 19.0661
736 3LAD FAD 19.0661
737 4KRI SAH 19.4553
738 1D4D FAD 19.4553
739 4YUW 4JU 19.8444
740 4YUW S4M 19.8444
741 1ZEM NAD 19.8444
742 4R6W PC 20.6226
743 4R6W SAH 20.6226
744 5YF1 8V0 21.0117
745 5YF1 SFG 21.0117
746 2PWY SAH 21.7054
747 5MGZ SAH 21.7899
748 3L9W AMP 22.179
749 3L9W GSH 22.179
750 1JQ3 AAT 24.1245
751 5M58 SAH 24.3478
752 4IWN GEK 24.4541
753 1VE3 SAM 24.6696
754 5E1M SAH 25.3112
755 5E1M PRO PRO LYS ARG ILE ALA 25.3112
756 4QTU SAM 25.9615
757 4ZVV NAD 26.07
758 4ZVV GN0 26.07
759 6D6Y SAH 28.4047
760 5JGL SAM 28.7938
761 5W7K SAH 29.572
762 6F5Z SAH 30.303
763 5MPT SAH 30.7393
764 5W7M SAH 38.1323
765 5E8J SAH 38.6364
Pocket No.: 2; Query (leader) PDB : 4OBW; Ligand: SAM; Similar sites found with APoc: 143
This union binding pocket(no: 2) in the query (biounit: 4obw.bio1) has 20 residues
No: Leader PDB Ligand Sequence Similarity
1 6F5W KG1 1.16732
2 5O2J 2PO 1.16732
3 1KR3 113 1.94553
4 5XWV NDP 2.33463
5 5XWV 8H6 2.33463
6 2HIM ASN 2.33463
7 2RGH FAD 2.33463
8 1GR0 NAD 2.33463
9 2HIM ASP 2.33463
10 1SZD APR 2.33463
11 1H2B NAJ 2.33463
12 3SJ7 NDP 2.38095
13 2C7G FAD 2.72374
14 2C7G ODP 2.72374
15 4BJZ FAD 2.72374
16 4BJZ P3A 2.72374
17 2A92 NAI 2.72374
18 2WET FAD 2.72374
19 1R37 NAD 2.72374
20 1H9A NAP 2.72374
21 5GT9 NAP 2.72374
22 1GV0 NAD 2.72374
23 1HKU NAD 2.72374
24 2JL1 NAP 2.72374
25 1UKG MMA 2.77778
26 2GN3 MMA 2.77778
27 2GN3 MAN 2.77778
28 1Q8Q MAN MMA 2.77778
29 2GNM MAN 2.77778
30 1Q8S MAN MMA 2.77778
31 1O5I NAD 2.81124
32 1EDO NAP 2.86885
33 2OEM 1AE 3.11284
34 4D04 FAD 3.11284
35 4D04 NAP 3.11284
36 4RF2 NAP 3.11284
37 1GPE FAD 3.11284
38 1LLU NAD 3.11284
39 1JNR FAD 3.33333
40 3FG2 FAD 3.46535
41 5TTJ FAD 3.50195
42 4MIG G3F 3.50195
43 2JB2 PHE 3.50195
44 2JB2 FAD 3.50195
45 1MXG ACR 3.50195
46 4J1Q NDP 3.50195
47 1T26 GBD 3.50195
48 1T26 NAI 3.50195
49 5J7X FAD 3.50195
50 2ZAT NAP 3.50195
51 3VZS NAP 3.50195
52 2Q1S NAI 3.50195
53 1MO9 FAD 3.82409
54 1MO9 KPC 3.82409
55 2JK0 ASP 3.89105
56 1J49 NAD 3.89105
57 6CA4 MLI 4
58 1UXG NAD 4.28016
59 1UXG FUM 4.28016
60 1V35 NAI 4.28016
61 3GD8 GOL 4.28016
62 5Y77 FAD 4.28016
63 3T31 FAD 4.28016
64 3T31 DCQ 4.28016
65 1VJT NAD 4.28016
66 3LZW NAP 4.66926
67 1RM0 NAI 4.66926
68 1RM0 D6P 4.66926
69 5NMX FAD 4.66926
70 1ZK4 NAP 4.66926
71 2DFV NAD 4.66926
72 1DSS NAD 4.66926
73 3AD8 FAD 5.05051
74 3AD8 PYC 5.05051
75 5HSA FAS 5.05837
76 3LXD FAD 5.05837
77 4L9Z OXL 5.05837
78 1VKO NAD 5.05837
79 2AQJ FAD 5.05837
80 2AQJ TRP 5.05837
81 1USI PHE 5.05837
82 3QVP FAD 5.05837
83 2RAB FAD 5.44747
84 2Q0L NAP 5.44747
85 4XF6 ADP 5.83658
86 4XF6 LIP 5.83658
87 4XF6 INS 5.83658
88 4EDF UPG 5.83658
89 5THQ NDP 6.22568
90 2GMH FAD 6.22568
91 5A1S FLC 6.22568
92 2XYQ SAH 6.55738
93 3E1T FAD 6.61479
94 2RGJ FAD 6.61479
95 4PLT OXM 7.00389
96 5JVB 2PO 7.00389
97 3NJ4 AFX 7.12644
98 5HXI 5HN 7.393
99 3CGD FAD 7.7821
100 3CGD COA 7.7821
101 3CGB FAD 7.7821
102 3CGD NAD 7.7821
103 3WV8 ATP 7.7821
104 2GAG FOA 8.08081
105 2GAG FAD 8.08081
106 3N8K D1X 8.13953
107 3NT6 FAD 8.56031
108 3U31 NAD 8.56031
109 5L6G XYP 8.56031
110 1PL6 572 8.94942
111 1PL6 NAD 8.94942
112 5MBX FAD 9.72763
113 5MBX SP5 9.72763
114 1EK6 NAI 9.72763
115 1EK6 UPG 9.72763
116 4PLG OXM 10.1167
117 4PLG NAI 10.1167
118 3UCL FAD 10.5058
119 3UCL NAP 10.5058
120 3UCL CYH 10.5058
121 2YVJ FAD 11.0092
122 2YVJ NAI 11.0092
123 3R51 MMA 11.25
124 3PNL ADP 11.284
125 5WUW NAP 11.284
126 3F8D FAD 12.0623
127 1RJW ETF 12.0623
128 3QJ4 FAD 13.2296
129 1NVM NAD 13.2296
130 3KIH GDL 13.4021
131 5ZZ6 NAD 13.4615
132 2GN4 NDP 13.6187
133 5JCA FAD 14.0078
134 5JCA NDP 14.0078
135 4J56 FAD 14.0351
136 1GUZ NAD 14.786
137 1NNU NAD 15
138 4G5H UD7 18.677
139 4G5H NAP 18.677
140 5UAV TFB 18.677
141 5UAV NDP 18.677
142 1HFE CYS 20.2335
143 3OJO NAD 21.4008
Pocket No.: 3; Query (leader) PDB : 4OBW; Ligand: SAM; Similar sites found with APoc: 42
This union binding pocket(no: 3) in the query (biounit: 4obw.bio2) has 23 residues
No: Leader PDB Ligand Sequence Similarity
1 5AOA PPI 1.16732
2 1T3D CYS 1.55642
3 6FLZ MMA 2.08333
4 6FV4 16G 2.33463
5 4U63 MHF 2.33463
6 2BQP GLC 2.5641
7 2CUN 3PG 2.72374
8 1FX8 BOG 2.72374
9 5FG3 GDP 2.72374
10 2GNB MAN 2.77778
11 5W3Y ACO 3.11284
12 1TD2 PXL 3.13589
13 2WYV NAD 3.50195
14 1LES GLC FRU 3.8674
15 5OVK NDP 3.89105
16 5BVE 4VG 3.89105
17 5CK5 GDP 3.89105
18 1O9W NAG 3.9548
19 2JAP NDP 4.28016
20 2VNO GAL GAL FUC 5
21 2VHL GLP 5.05837
22 4IKZ AFS 5.44747
23 1UYY BGC BGC 6.10687
24 1RKX NAD 6.22568
25 2ZWI C5P 6.22568
26 2Z49 AMG 7.00389
27 1VAY AZA 7.31707
28 2EXX NAP 7.393
29 1TZJ A3B 7.7821
30 4YNU LGC 8.17121
31 2OG2 MLI 8.17121
32 3V2U GLA 8.17121
33 4JX1 CAH 8.84956
34 5T52 NGA 11.157
35 4OHU NAD 11.6732
36 4OHU 2TK 11.6732
37 1SQL GUN 12.3288
38 2J5V PCA 13.6187
39 5LX9 OLB 15.1751
40 3CL7 HYN 17.5097
41 3HB5 NAP 17.8988
42 4JCA CIT 22.1557
Pocket No.: 4; Query (leader) PDB : 4OBW; Ligand: SAM; Similar sites found with APoc: 15
This union binding pocket(no: 4) in the query (biounit: 4obw.bio2) has 22 residues
No: Leader PDB Ligand Sequence Similarity
1 3NV6 CAM 1.55642
2 3G2Y GF4 2.33463
3 1COY FAD 2.72374
4 2IF8 ADP 2.72374
5 3WXB NDP 3.11284
6 3SQP FAD 3.89105
7 1US2 XYP XYP XYP XYP 4.28016
8 3VV1 GAL FUC 5.625
9 1HYH NAD 5.83658
10 1KNR FAD 8.56031
11 5T52 A2G 11.157
12 2H7C SIA 12.0623
13 4AKB GAL 13.5338
14 1RHC F42 ACN 15.9533
15 5XPI 8C3 20.3822
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