Receptor
PDB id Resolution Class Description Source Keywords
4O1P 2.5 Å EC: 7.-.-.- CRYSTAL STRUCTURE OF RNASE L IN COMPLEX WITH 2-5A AND AMP-PN SUS SCROFA ANKYRIN REPEAT-KINASE-RNASE RNA CLEAVAGE 2-5A TRANSFERASEHYDROLASE
Ref.: DIMERIC STRUCTURE OF PSEUDOKINASE RNASE L BOUND TO REVEALS A BASIS FOR INTERFERON-INDUCED ANTIVIRAL AC MOL.CELL V. 53 221 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ANP B:901;
C:901;
D:901;
A:901;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
506.196 C10 H17 N6 O12 P3 c1nc(...
MG A:903;
B:902;
C:903;
D:902;
D:903;
A:902;
B:903;
C:902;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
24.305 Mg [Mg+2...
25L C:904;
D:904;
A:904;
B:904;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
1165.59 C30 H40 N15 O25 P5 c1nc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4O1P 2.5 Å EC: 7.-.-.- CRYSTAL STRUCTURE OF RNASE L IN COMPLEX WITH 2-5A AND AMP-PN SUS SCROFA ANKYRIN REPEAT-KINASE-RNASE RNA CLEAVAGE 2-5A TRANSFERASEHYDROLASE
Ref.: DIMERIC STRUCTURE OF PSEUDOKINASE RNASE L BOUND TO REVEALS A BASIS FOR INTERFERON-INDUCED ANTIVIRAL AC MOL.CELL V. 53 221 2014
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 311 families.
1 4O1P - 25L C30 H40 N15 O25 P5 c1nc(c2c(n....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 266 families.
1 4OAV - PO4 PO4 A A A A PO4 n/a n/a
2 4O1P - 25L C30 H40 N15 O25 P5 c1nc(c2c(n....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 218 families.
1 4OAV - PO4 PO4 A A A A PO4 n/a n/a
2 4O1P - 25L C30 H40 N15 O25 P5 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ANP; Similar ligands found: 397
No: Ligand ECFP6 Tc MDL keys Tc
1 ANP 1 1
2 A2D 0.810811 0.945205
3 AP5 0.802632 0.945205
4 B4P 0.802632 0.945205
5 ADP 0.802632 0.972222
6 BA3 0.789474 0.945205
7 AU1 0.782051 1
8 ATP 0.772152 0.972222
9 HEJ 0.772152 0.972222
10 AN2 0.769231 0.986111
11 AT4 0.769231 0.933333
12 5FA 0.7625 0.972222
13 AQP 0.7625 0.972222
14 M33 0.759494 0.932432
15 MAP 0.752941 0.972973
16 ACP 0.75 0.945946
17 AR6 0.740741 0.945205
18 APR 0.740741 0.945205
19 ACQ 0.73494 0.945946
20 SAP 0.731707 0.921053
21 AD9 0.731707 0.945946
22 AGS 0.731707 0.921053
23 KG4 0.728395 0.92
24 AMP 0.723684 0.944444
25 A 0.723684 0.944444
26 ATF 0.717647 0.933333
27 ADX 0.716049 0.851852
28 CA0 0.716049 0.92
29 6YZ 0.709302 0.945946
30 50T 0.707317 0.932432
31 PRX 0.698795 0.87013
32 45A 0.696203 0.893333
33 ABM 0.696203 0.893333
34 HQG 0.681818 0.958904
35 AP2 0.679012 0.933333
36 A12 0.679012 0.933333
37 APC 0.678571 0.933333
38 T99 0.674419 0.933333
39 TAT 0.674419 0.933333
40 A22 0.674157 0.958904
41 SRA 0.670886 0.894737
42 SRP 0.670455 0.883117
43 8LE 0.666667 0.871795
44 5AL 0.666667 0.906667
45 ADP MG 0.662651 0.917808
46 A1R 0.659341 0.884615
47 ADQ 0.659341 0.92
48 A3R 0.659341 0.884615
49 8LH 0.651685 0.883117
50 BIS 0.648936 0.909091
51 3OD 0.648936 0.92
52 5SV 0.648352 0.82716
53 9X8 0.645161 0.896104
54 OAD 0.645161 0.92
55 25L 0.642105 0.958904
56 AMO 0.641304 0.907895
57 8LQ 0.637363 0.883117
58 G5P 0.636364 0.897436
59 00A 0.634409 0.860759
60 DLL 0.634409 0.906667
61 AHX 0.634409 0.897436
62 APC MG 0.632184 0.893333
63 ATP MG 0.632184 0.917808
64 ADV 0.632184 0.907895
65 ADP PO3 0.632184 0.917808
66 RBY 0.632184 0.907895
67 NB8 0.631579 0.897436
68 25A 0.630435 0.945205
69 8QN 0.630435 0.906667
70 OZV 0.630435 0.945205
71 OOB 0.630435 0.906667
72 G3A 0.626263 0.897436
73 PAJ 0.623656 0.8625
74 4AD 0.623656 0.896104
75 LAD 0.621053 0.839506
76 1ZZ 0.614583 0.819277
77 TXA 0.614583 0.907895
78 ME8 0.614583 0.819277
79 GTA 0.613861 0.864198
80 9ZA 0.612903 0.909091
81 9ZD 0.612903 0.909091
82 3UK 0.610526 0.894737
83 SON 0.604651 0.907895
84 ADP ALF 0.604396 0.848101
85 ALF ADP 0.604396 0.848101
86 PR8 0.604167 0.829268
87 B5V 0.604167 0.883117
88 WAQ 0.604167 0.860759
89 4UV 0.6 0.871795
90 GAP 0.6 0.87013
91 PTJ 0.597938 0.873418
92 FYA 0.597938 0.881579
93 ADP VO4 0.597826 0.906667
94 VO4 ADP 0.597826 0.906667
95 LMS 0.597561 0.829268
96 UP5 0.596154 0.896104
97 FA5 0.59596 0.883117
98 YAP 0.59596 0.871795
99 PAP 0.595506 0.958333
100 A4P 0.59434 0.823529
101 XAH 0.59 0.841463
102 4UU 0.588235 0.871795
103 AFH 0.588235 0.8625
104 9SN 0.585859 0.85
105 2A5 0.58427 0.894737
106 T5A 0.583333 0.821429
107 DQV 0.582524 0.932432
108 NAI 0.580952 0.884615
109 B5Y 0.58 0.871795
110 B5M 0.58 0.871795
111 ITT 0.579545 0.917808
112 ATR 0.577778 0.944444
113 OMR 0.575472 0.831325
114 5AS 0.574713 0.781609
115 48N 0.571429 0.873418
116 YLP 0.571429 0.8
117 AP0 0.570093 0.873418
118 4TC 0.570093 0.873418
119 7D3 0.569767 0.881579
120 ADJ 0.568807 0.831325
121 9GM 0.568421 0.922078
122 GNP 0.568421 0.922078
123 DAL AMP 0.568421 0.881579
124 NAX 0.566038 0.851852
125 4UW 0.566038 0.839506
126 TXD 0.566038 0.884615
127 NXX 0.566038 0.907895
128 DND 0.566038 0.907895
129 6V0 0.566038 0.873418
130 RAB 0.565789 0.821918
131 ADN 0.565789 0.821918
132 XYA 0.565789 0.821918
133 AOC 0.564706 0.8
134 7D4 0.561798 0.881579
135 ADP BMA 0.561224 0.894737
136 TYM 0.560748 0.883117
137 TXE 0.560748 0.884615
138 GA7 0.557692 0.883117
139 YLB 0.555556 0.8
140 YLC 0.555556 0.819277
141 139 0.554545 0.851852
142 5N5 0.551282 0.797297
143 JB6 0.55 0.860759
144 LAQ 0.54717 0.819277
145 F2R 0.544643 0.843373
146 MYR AMP 0.544554 0.797619
147 A4D 0.544304 0.797297
148 5CD 0.544304 0.783784
149 80F 0.54386 0.821429
150 7MD 0.542857 0.864198
151 6AD 0.542553 0.886076
152 A2R 0.541667 0.958904
153 UPA 0.541284 0.884615
154 YLA 0.540541 0.8
155 A A 0.54 0.918919
156 COD 0.539823 0.793103
157 BTX 0.539823 0.821429
158 JSQ 0.537634 0.921053
159 G5A 0.537634 0.781609
160 HFD 0.537634 0.921053
161 AYB 0.535714 0.790698
162 CNA 0.535714 0.907895
163 3DH 0.535714 0.753247
164 BT5 0.535088 0.811765
165 ATP A 0.533981 0.905405
166 ATP A A A 0.533981 0.905405
167 IOT 0.531532 0.811765
168 MTA 0.53012 0.753247
169 3AM 0.529412 0.90411
170 A3P 0.52809 0.944444
171 NAD 0.526316 0.906667
172 PPS 0.526316 0.851852
173 NO7 0.525773 0.907895
174 EP4 0.52439 0.734177
175 AMP DBH 0.52381 0.87013
176 7D5 0.52381 0.855263
177 J7C 0.522727 0.75
178 H1Q 0.521739 0.88
179 A5A 0.520833 0.809524
180 EAD 0.520661 0.851852
181 TSB 0.520408 0.821429
182 AHZ 0.518519 0.797619
183 M2T 0.518072 0.716049
184 DTA 0.518072 0.766234
185 6RE 0.517241 0.740741
186 A3D 0.517241 0.894737
187 YLY 0.516949 0.790698
188 SSA 0.515464 0.802326
189 NA7 0.514852 0.933333
190 ARG AMP 0.514019 0.809524
191 AR6 AR6 0.514019 0.893333
192 7MC 0.513514 0.843373
193 A2P 0.511111 0.930556
194 52H 0.510204 0.781609
195 VMS 0.510204 0.790698
196 54H 0.510204 0.790698
197 TYR AMP 0.509434 0.848101
198 TAD 0.509259 0.8625
199 NAQ 0.508333 0.85
200 A3N 0.505618 0.766234
201 AV2 0.505155 0.893333
202 53H 0.50505 0.781609
203 5CA 0.50505 0.802326
204 8X1 0.50505 0.755556
205 ARU 0.504951 0.839506
206 ZID 0.504132 0.894737
207 P1H 0.504 0.831325
208 AVV 0.5 0.873418
209 3AT 0.5 0.945205
210 NAE 0.5 0.871795
211 6MZ 0.5 0.905405
212 P5A 0.495146 0.747253
213 LSS 0.49505 0.764045
214 NSS 0.49505 0.802326
215 DSZ 0.49505 0.802326
216 N0B 0.491803 0.8
217 AF3 ADP 3PG 0.491071 0.817073
218 NVA LMS 0.490196 0.755556
219 DAT 0.489362 0.881579
220 IMO 0.488889 0.90411
221 ZAS 0.488636 0.792208
222 FDA 0.488372 0.813953
223 NAJ PZO 0.487395 0.85
224 4TA 0.487179 0.788235
225 LPA AMP 0.486486 0.797619
226 LEU LMS 0.485437 0.755556
227 DTP 0.484536 0.881579
228 V3L 0.484536 0.945205
229 GJV 0.483516 0.731707
230 S4M 0.483516 0.651685
231 DZD 0.483051 0.8625
232 2AM 0.482759 0.917808
233 5AD 0.481013 0.726027
234 GSU 0.480769 0.781609
235 KAA 0.480769 0.755556
236 NDE 0.480315 0.907895
237 M24 0.479339 0.851852
238 MAO 0.478261 0.761905
239 NEC 0.477778 0.727273
240 DSH 0.477778 0.707317
241 FAS 0.477273 0.831325
242 FAD 0.477273 0.831325
243 RGT 0.476636 0.933333
244 9K8 0.47619 0.698925
245 G A A A 0.474576 0.85
246 0WD 0.474576 0.897436
247 FNK 0.474074 0.786517
248 5X8 0.473684 0.74359
249 6FA 0.473282 0.821429
250 NDC 0.472868 0.85
251 FB0 0.472868 0.786517
252 YSA 0.472222 0.781609
253 7DD 0.468085 0.958333
254 OVE 0.466667 0.881579
255 MHZ 0.463158 0.701149
256 8PZ 0.462963 0.802326
257 AMP NAD 0.462185 0.881579
258 A G 0.462185 0.860759
259 N5O 0.461538 0.74359
260 A3G 0.461538 0.779221
261 NAJ PYZ 0.459677 0.809524
262 6C6 0.459184 0.858974
263 LQJ 0.458716 0.893333
264 B1U 0.458716 0.758242
265 SFG 0.458333 0.730769
266 U A G G 0.458333 0.860759
267 7D7 0.45679 0.723684
268 128 0.45614 0.8
269 SFD 0.455224 0.736842
270 6IA 0.454545 0.817073
271 DDS 0.454545 0.855263
272 GDP 0.454545 0.896104
273 ODP 0.453782 0.886076
274 NJP 0.453782 0.921053
275 7DT 0.453608 0.958333
276 J4G 0.45283 0.896104
277 A7D 0.452632 0.75641
278 Z5A 0.452381 0.802326
279 WSA 0.452174 0.790698
280 N5A 0.451613 0.717949
281 U A 0.45082 0.884615
282 7C5 0.45045 0.797468
283 FAY 0.449275 0.841463
284 NDP 0.449153 0.897436
285 SA8 0.44898 0.690476
286 A5D 0.44898 0.766234
287 71V 0.446809 0.884615
288 GGZ 0.446602 0.804878
289 RFL 0.446043 0.802326
290 2SA 0.445545 0.907895
291 SAI 0.444444 0.716049
292 SAH 0.444444 0.725
293 GP3 0.444444 0.897436
294 A A A 0.443396 0.881579
295 PO4 PO4 A A A A PO4 0.443396 0.878378
296 4YB 0.442478 0.764045
297 S7M 0.441176 0.674419
298 GTP 0.441176 0.896104
299 SMM 0.441176 0.670455
300 Y3J 0.440476 0.706667
301 SAM 0.44 0.674419
302 649 0.439655 0.747253
303 12D 0.438596 0.809524
304 A3S 0.4375 0.789474
305 NPW 0.436975 0.864198
306 GCP 0.436893 0.873418
307 EEM 0.435644 0.674419
308 GNH 0.435644 0.909091
309 AAT 0.435644 0.690476
310 ETB 0.435484 0.813953
311 DCA 0.435484 0.804598
312 KOY 0.434783 0.782051
313 N6P 0.433962 0.890411
314 TXP 0.433333 0.897436
315 NZQ 0.433333 0.886076
316 PGS 0.43299 0.860759
317 APU 0.432203 0.871795
318 PUA 0.432 0.8625
319 62F 0.431655 0.841463
320 F2N 0.431507 0.795455
321 DA 0.430108 0.855263
322 D5M 0.430108 0.855263
323 J7V 0.429688 0.813953
324 A3T 0.428571 0.8
325 6K6 0.428571 0.905405
326 NIA 0.428571 0.848101
327 0T1 0.428571 0.804598
328 COA 0.428571 0.804598
329 P5F 0.427586 0.804598
330 AAM 0.425532 0.944444
331 0UM 0.424528 0.682353
332 8Q2 0.423729 0.775281
333 G1R 0.423077 0.884615
334 C2R 0.422222 0.88
335 AMZ 0.422222 0.891892
336 A U 0.420168 0.848101
337 IDP 0.42 0.894737
338 GSP 0.419048 0.851852
339 CAO 0.418605 0.777778
340 1DG 0.418605 0.897436
341 AMX 0.418605 0.813953
342 COS 0.418605 0.786517
343 30N 0.418605 0.736842
344 DG1 0.418605 0.897436
345 TM1 0.418182 0.797619
346 9BG 0.418033 0.873418
347 A6D 0.416667 0.746988
348 K15 0.416667 0.666667
349 V1N 0.415929 0.893333
350 CMX 0.415385 0.804598
351 SCO 0.415385 0.804598
352 GEK 0.415094 0.719512
353 NHD 0.414634 0.881579
354 XNP 0.414634 0.851852
355 AIR 0.413793 0.876712
356 9JJ 0.413793 0.841463
357 COK 0.413534 0.786517
358 G2R 0.412844 0.8625
359 ACO 0.412214 0.777778
360 FCX 0.412214 0.777778
361 FAM 0.412214 0.786517
362 NAP 0.410853 0.92
363 FA9 0.409396 0.843373
364 SXZ 0.409091 0.694118
365 HAX 0.409091 0.806818
366 TAP 0.407692 0.884615
367 62X 0.407407 0.651685
368 2MC 0.407407 0.752688
369 GKE 0.40708 0.8625
370 GDD 0.40708 0.8625
371 GDC 0.40708 0.8625
372 FYN 0.406015 0.804598
373 3KK 0.406015 0.786517
374 NVA 2AD 0.405941 0.740741
375 NA0 0.40458 0.907895
376 101 0.404255 0.855263
377 5GP 0.40404 0.883117
378 G 0.40404 0.883117
379 HDV 0.403846 0.87013
380 MGP 0.403846 0.8625
381 SOP 0.402985 0.786517
382 OXK 0.402985 0.786517
383 MCD 0.402985 0.786517
384 CA6 0.402985 0.714286
385 YZS 0.402985 0.714286
386 KGP 0.402985 0.714286
387 3AD 0.402299 0.783784
388 S8M 0.401869 0.78481
389 YE1 0.40146 0.795455
390 1VU 0.4 0.777778
391 6G0 0.4 0.8625
392 GMV 0.4 0.873418
393 CMC 0.4 0.786517
394 2VA 0.4 0.779221
395 NMX 0.4 0.782609
396 CO6 0.4 0.786517
397 7RP 0.4 0.902778
Ligand no: 2; Ligand: 25L; Similar ligands found: 342
No: Ligand ECFP6 Tc MDL keys Tc
1 25L 1 1
2 25A 0.862069 0.985915
3 ATP 0.809524 0.985915
4 HEJ 0.809524 0.985915
5 A22 0.808989 1
6 5FA 0.8 0.985915
7 AQP 0.8 0.985915
8 AP5 0.752941 0.985915
9 B4P 0.752941 0.985915
10 BA3 0.741176 0.985915
11 ADP 0.732558 0.985915
12 AGS 0.730337 0.933333
13 SAP 0.730337 0.933333
14 A2D 0.717647 0.985915
15 ATR 0.711111 0.957747
16 6YZ 0.691489 0.958904
17 AN2 0.685393 0.972222
18 AT4 0.666667 0.945946
19 A2R 0.666667 0.972222
20 AR6 0.663043 0.958333
21 APR 0.663043 0.958333
22 T99 0.659574 0.945946
23 TAT 0.659574 0.945946
24 ACQ 0.659574 0.958904
25 M33 0.659341 0.945205
26 AD9 0.655914 0.958904
27 ACP 0.652174 0.958904
28 HQG 0.649485 0.972222
29 ADQ 0.646465 0.958904
30 A 0.643678 0.957747
31 AMP 0.643678 0.957747
32 ANP 0.642105 0.958904
33 NA7 0.633663 0.945946
34 A2P 0.626374 0.943662
35 ADX 0.623656 0.8625
36 CA0 0.623656 0.932432
37 ITT 0.623656 0.930556
38 OAD 0.617647 0.932432
39 9X8 0.617647 0.907895
40 50T 0.617021 0.945205
41 KG4 0.617021 0.932432
42 A3R 0.613861 0.896104
43 ATF 0.612245 0.945946
44 APC 0.610526 0.945946
45 PRX 0.610526 0.881579
46 7D4 0.606383 0.893333
47 ABM 0.604396 0.905405
48 45A 0.604396 0.905405
49 SRA 0.6 0.906667
50 A1R 0.598039 0.896104
51 UPA 0.59292 0.921053
52 A12 0.591398 0.945946
53 AP2 0.591398 0.945946
54 BIS 0.590476 0.921053
55 3OD 0.590476 0.932432
56 8LE 0.585859 0.883117
57 5AL 0.585859 0.918919
58 G5P 0.581818 0.934211
59 HFD 0.581633 0.933333
60 JSQ 0.581633 0.933333
61 ADP MG 0.578947 0.930556
62 UP5 0.575221 0.933333
63 8LH 0.574257 0.894737
64 SRP 0.574257 0.894737
65 AU1 0.572917 0.958904
66 OZV 0.572816 0.958333
67 5SV 0.572816 0.8375
68 G3A 0.572727 0.934211
69 PAP 0.571429 0.971831
70 APC MG 0.571429 0.905405
71 PAJ 0.567308 0.873418
72 4AD 0.567308 0.907895
73 8LQ 0.563107 0.894737
74 GTA 0.5625 0.898734
75 00A 0.561905 0.896104
76 2A5 0.561224 0.906667
77 PTJ 0.560748 0.884615
78 OOB 0.557692 0.945205
79 8QN 0.557692 0.918919
80 OMR 0.556522 0.841463
81 ATP MG 0.555556 0.930556
82 RBY 0.555556 0.92
83 ADP PO3 0.555556 0.930556
84 ADV 0.555556 0.92
85 NJP 0.554622 0.959459
86 AFH 0.553571 0.897436
87 AMO 0.552381 0.92
88 AP0 0.551724 0.909091
89 NPW 0.550847 0.898734
90 NDP 0.550847 0.934211
91 2AM 0.549451 0.930556
92 MAP 0.548077 0.933333
93 NAX 0.547826 0.886076
94 NAI 0.547826 0.921053
95 DLL 0.54717 0.945205
96 AHX 0.54717 0.884615
97 A4P 0.547009 0.855422
98 1ZZ 0.546296 0.829268
99 FYA 0.546296 0.918919
100 NZQ 0.546219 0.922078
101 TXP 0.546219 0.934211
102 3AT 0.544554 0.958333
103 3UK 0.542056 0.932432
104 ADP BMA 0.542056 0.932432
105 ODP 0.541667 0.922078
106 AR6 AR6 0.539823 0.931507
107 T5A 0.537815 0.853659
108 LMS 0.537634 0.817073
109 B5V 0.537037 0.92
110 PR8 0.537037 0.839506
111 WAQ 0.537037 0.871795
112 LAD 0.537037 0.85
113 DQV 0.535088 0.972222
114 TXD 0.534483 0.921053
115 6V0 0.534483 0.909091
116 ALF ADP 0.533981 0.858974
117 ADP ALF 0.533981 0.858974
118 NB8 0.53211 0.884615
119 TXA 0.53211 0.92
120 ME8 0.53211 0.829268
121 OVE 0.531915 0.893333
122 7D3 0.53125 0.893333
123 SON 0.530612 0.92
124 TXE 0.529915 0.921053
125 GAP 0.529412 0.881579
126 DTP 0.529412 0.893333
127 V3L 0.529412 0.958333
128 VO4 ADP 0.528846 0.918919
129 ADP VO4 0.528846 0.918919
130 PO4 PO4 A A A A PO4 0.527778 0.916667
131 48N 0.525862 0.884615
132 139 0.525 0.886076
133 XNP 0.52459 0.886076
134 XYA 0.523256 0.833333
135 RAB 0.523256 0.833333
136 ADN 0.523256 0.833333
137 9SN 0.522523 0.884615
138 DND 0.521368 0.945946
139 NXX 0.521368 0.945946
140 DAL AMP 0.518868 0.893333
141 FA5 0.517857 0.92
142 B5Y 0.517857 0.907895
143 B5M 0.517857 0.907895
144 YAP 0.517857 0.907895
145 7DT 0.514852 0.971831
146 9ZD 0.514019 0.896104
147 9ZA 0.514019 0.896104
148 XAH 0.513274 0.829268
149 4TC 0.512605 0.909091
150 ADJ 0.512397 0.864198
151 COD 0.512195 0.802326
152 DG1 0.511628 0.934211
153 1DG 0.511628 0.934211
154 A3P 0.510204 0.957747
155 A A 0.509091 0.958333
156 4UV 0.508772 0.907895
157 CNA 0.508197 0.945946
158 5AS 0.50505 0.770115
159 ATP A A A 0.504425 0.944444
160 ATP A 0.504425 0.944444
161 LAQ 0.504274 0.829268
162 TYM 0.504202 0.92
163 80F 0.504 0.853659
164 DDS 0.5 0.866667
165 GA7 0.5 0.92
166 4UU 0.5 0.907895
167 4UW 0.495798 0.873418
168 PPS 0.495238 0.8625
169 6AD 0.495238 0.897436
170 AOC 0.494845 0.810811
171 3AM 0.494737 0.916667
172 NAP 0.492308 0.958904
173 9BG 0.491935 0.909091
174 F2R 0.491935 0.853659
175 RGT 0.491228 0.945946
176 JB6 0.491071 0.896104
177 TAP 0.48855 0.921053
178 YLP 0.487395 0.809524
179 LQJ 0.486957 0.931507
180 MYR AMP 0.486726 0.807229
181 NA0 0.484848 0.945946
182 7L1 0.484848 0.786517
183 TYR AMP 0.482759 0.883117
184 NO7 0.481481 0.92
185 5N5 0.477778 0.808219
186 AV2 0.476636 0.905405
187 G5A 0.47619 0.770115
188 0WD 0.47619 0.934211
189 NAD 0.47619 0.945205
190 NMN AMP PO4 0.47619 0.883117
191 YLB 0.47541 0.809524
192 YLC 0.47541 0.829268
193 ARG AMP 0.474576 0.819277
194 7MD 0.474576 0.851852
195 EAD 0.473684 0.886076
196 7D5 0.473684 0.866667
197 5CD 0.472527 0.794521
198 A4D 0.472527 0.808219
199 SSA 0.472222 0.790698
200 128 0.471074 0.788235
201 A3D 0.46875 0.932432
202 IOT 0.467742 0.821429
203 AHZ 0.466667 0.807229
204 GPG 0.464912 0.922078
205 BTX 0.464567 0.831325
206 YLA 0.464 0.809524
207 TSB 0.463636 0.809524
208 A5A 0.462963 0.797619
209 H1Q 0.461538 0.891892
210 DAT 0.461538 0.893333
211 AYB 0.460317 0.8
212 P1H 0.459854 0.864198
213 APU 0.459677 0.907895
214 AVV 0.459459 0.884615
215 GTP 0.458716 0.907895
216 TAD 0.458333 0.873418
217 AMP DBH 0.457627 0.906667
218 EP4 0.457447 0.74359
219 CO7 0.457143 0.795455
220 7DD 0.456311 0.971831
221 NSS 0.455357 0.790698
222 62F 0.455172 0.875
223 NAE 0.454545 0.907895
224 VMS 0.454545 0.77907
225 52H 0.454545 0.770115
226 54H 0.454545 0.77907
227 N01 0.453846 0.918919
228 3DH 0.453608 0.763158
229 DTA 0.452632 0.8
230 M2T 0.452632 0.725
231 7MC 0.451613 0.831325
232 NVA LMS 0.451327 0.744444
233 NAQ 0.451128 0.884615
234 LPA AMP 0.45082 0.807229
235 53H 0.45045 0.770115
236 5CA 0.45045 0.790698
237 8X1 0.45045 0.744444
238 BT5 0.449612 0.821429
239 HDV 0.449541 0.881579
240 MTA 0.447917 0.763158
241 ZID 0.447761 0.932432
242 5X8 0.447619 0.753247
243 ENP 0.447368 0.906667
244 LEU LMS 0.447368 0.744444
245 IMO 0.445545 0.916667
246 6FA 0.443662 0.853659
247 AF3 ADP 3PG 0.443548 0.82716
248 P5A 0.443478 0.736264
249 FB0 0.442857 0.795455
250 NAJ PZO 0.442748 0.860759
251 LSS 0.442478 0.752809
252 DSZ 0.442478 0.790698
253 G A A A 0.44186 0.884615
254 6MZ 0.441176 0.917808
255 6RE 0.44 0.75
256 NDE 0.438849 0.945946
257 ARU 0.438596 0.85
258 DZD 0.438462 0.897436
259 FAS 0.4375 0.864198
260 FAD 0.4375 0.864198
261 N0B 0.437037 0.831325
262 MAO 0.436893 0.75
263 YLY 0.43609 0.8
264 M24 0.43609 0.8625
265 6C6 0.435185 0.87013
266 NDC 0.432624 0.884615
267 U A 0.431818 0.921053
268 A3N 0.431373 0.776316
269 J7C 0.431373 0.759494
270 GSU 0.431034 0.770115
271 KAA 0.431034 0.744444
272 ZAS 0.43 0.75641
273 NAJ PYZ 0.42963 0.819277
274 ETB 0.428571 0.823529
275 DCA 0.428571 0.813953
276 SFD 0.427586 0.744681
277 9K8 0.42735 0.725275
278 S4M 0.427184 0.659091
279 FDA 0.426573 0.845238
280 N6P 0.426087 0.929577
281 B1U 0.425 0.747253
282 YSA 0.425 0.790698
283 2SA 0.423423 0.92
284 MGP 0.423423 0.873418
285 FAY 0.422819 0.875
286 A A A 0.422414 0.893333
287 COA 0.422222 0.813953
288 0T1 0.422222 0.813953
289 DSH 0.421569 0.716049
290 WSA 0.420635 0.8
291 RFL 0.42 0.833333
292 AMP NAD 0.419847 0.918919
293 A G 0.419847 0.896104
294 4TA 0.419847 0.819277
295 6G0 0.419643 0.873418
296 J4G 0.418803 0.907895
297 U A G G 0.416667 0.896104
298 8PZ 0.416667 0.811765
299 PUA 0.414815 0.897436
300 A U 0.414062 0.883117
301 GJV 0.413462 0.740741
302 CAO 0.413043 0.786517
303 AMX 0.413043 0.823529
304 COS 0.413043 0.795455
305 30N 0.413043 0.744681
306 ZDA 0.412844 0.853333
307 GSP 0.412281 0.8625
308 3KK 0.411348 0.795455
309 4YB 0.41129 0.772727
310 PGS 0.411215 0.871795
311 CMX 0.410072 0.813953
312 SCO 0.410072 0.813953
313 V1N 0.409836 0.931507
314 71V 0.409524 0.896104
315 9JJ 0.409091 0.875
316 GP3 0.409091 0.934211
317 GEK 0.408696 0.728395
318 CA6 0.408451 0.721649
319 OXK 0.408451 0.795455
320 12D 0.408 0.797619
321 NEC 0.407767 0.736842
322 A3G 0.407767 0.789474
323 SFG 0.407407 0.74026
324 ACO 0.407143 0.786517
325 FAM 0.407143 0.795455
326 FCX 0.407143 0.786517
327 MGO 0.40708 0.85
328 FNK 0.406667 0.816092
329 6IA 0.405405 0.82716
330 GDP 0.405405 0.907895
331 PRT 0.404959 0.918919
332 HAX 0.404255 0.795455
333 2MC 0.402778 0.76087
334 5AD 0.402174 0.736111
335 A7D 0.401869 0.766234
336 AAT 0.401786 0.698795
337 FYN 0.401408 0.813953
338 LRM 0.40113 0.835294
339 A5D 0.4 0.8
340 GGZ 0.4 0.814815
341 SA8 0.4 0.698795
342 IVC 0.4 0.804598
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4O1P; Ligand: ANP; Similar sites found with APoc: 41
This union binding pocket(no: 1) in the query (biounit: 4o1p.bio2) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 5WNL STU 4.38596
2 5WNL STU 4.38596
3 2WU6 DKI 4.98688
4 4QTB 38Z 5.78947
5 4QTB 38Z 5.78947
6 5EFQ ADP 7.20461
7 5EFQ ADP 7.20461
8 4OH4 ANP 7.20721
9 3RWP ABQ 8.03859
10 3RWP ABQ 8.03859
11 4BFM ANP 8.08383
12 2BPM 529 8.09062
13 4CFU 2WC 8.25082
14 2Z7R STU 8.41121
15 4H3P ANP 8.83978
16 4CLI 5P8 9.17431
17 3E8N ATP 12.9032
18 3E8N VRA 12.9032
19 3E8N VRA 12.9032
20 3E8N ATP 12.9032
21 3SLS ANP 14.4737
22 3SLS ANP 14.4737
23 3FC2 IBI 15.5224
24 1PHK ATP 16.7785
25 1U5R ATP 17.2414
26 1U5R ATP 17.2414
27 1U5R ATP 17.2414
28 3BU5 ATP 17.6471
29 1IR3 ANP 17.6471
30 3TKI S25 17.9567
31 3PLS ANP 19.1275
32 4WNP 3RJ 20.2091
33 4WNP 3RJ 20.2091
34 5X8I SQZ 20.5202
35 5HCY 60D 20.5438
36 6F3G CJN 21.0169
37 5XVG 8FX 22.8669
38 2VN9 GVD 23.2558
39 5LXM ADP 34.2105
40 2RIO ADP 36.6359
41 2RIO ADP 36.6359
Pocket No.: 2; Query (leader) PDB : 4O1P; Ligand: 25L; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 4o1p.bio2) has 25 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 4O1P; Ligand: ANP; Similar sites found with APoc: 23
This union binding pocket(no: 3) in the query (biounit: 4o1p.bio2) has 20 residues
No: Leader PDB Ligand Sequence Similarity
1 2WU6 DKI 4.98688
2 4QTB 38Z 5.78947
3 4QTB 38Z 5.78947
4 5EFQ ADP 7.20461
5 3RWP ABQ 8.03859
6 3RWP ABQ 8.03859
7 4CFU 2WC 8.25082
8 3E8N ATP 12.9032
9 3E8N VRA 12.9032
10 3E8N VRA 12.9032
11 3E8N ATP 12.9032
12 1PHK ATP 16.7785
13 1U5R ATP 17.2414
14 1U5R ATP 17.2414
15 3BU5 ATP 17.6471
16 3TKI S25 17.9567
17 3PLS ANP 19.1275
18 4WNP 3RJ 20.2091
19 6F3G CJN 21.0169
20 2VN9 GVD 23.2558
21 5LXM ADP 34.2105
22 2RIO ADP 36.6359
23 2RIO ADP 36.6359
Pocket No.: 4; Query (leader) PDB : 4O1P; Ligand: 25L; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 4o1p.bio2) has 25 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 4O1P; Ligand: ANP; Similar sites found with APoc: 28
This union binding pocket(no: 5) in the query (biounit: 4o1p.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 6JKM ADP 5.27859
2 4QTB 38Z 5.78947
3 4NM5 ADP 6.36605
4 5EFQ ADP 7.20461
5 4OH4 ANP 7.20721
6 3RWP ABQ 8.03859
7 3RWP ABQ 8.03859
8 4CFU 2WC 8.25082
9 2Z7R STU 8.41121
10 4CLI 5P8 9.17431
11 3DAK ANP 9.31034
12 3E8N VRA 12.9032
13 3E8N ATP 12.9032
14 3SLS ANP 14.4737
15 4C2W ANP 16.129
16 1U5R ATP 17.2414
17 3BU5 ATP 17.6471
18 1IR3 ANP 17.6471
19 3PLS ANP 19.1275
20 4WNP 3RJ 20.2091
21 4WNP 3RJ 20.2091
22 6F3G CJN 21.0169
23 2VN9 GVD 23.2558
24 2VN9 GVD 23.2558
25 5G1X ADP 27.7193
26 5LXM ADP 34.2105
27 2RIO ADP 36.6359
28 2RIO ADP 36.6359
Pocket No.: 6; Query (leader) PDB : 4O1P; Ligand: 25L; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 4o1p.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 7; Query (leader) PDB : 4O1P; Ligand: 25L; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 7) in the query (biounit: 4o1p.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 8; Query (leader) PDB : 4O1P; Ligand: ANP; Similar sites found with APoc: 26
This union binding pocket(no: 8) in the query (biounit: 4o1p.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 6JKM ADP 5.27859
2 4QTB 38Z 5.78947
3 4NM5 ADP 6.36605
4 5EFQ ADP 7.20461
5 4OH4 ANP 7.20721
6 3RWP ABQ 8.03859
7 3RWP ABQ 8.03859
8 4CFU 2WC 8.25082
9 2Z7R STU 8.41121
10 4CLI 5P8 9.17431
11 3DAK ANP 9.31034
12 3E8N VRA 12.9032
13 3E8N ATP 12.9032
14 4C2W ANP 16.129
15 1U5R ATP 17.2414
16 3BU5 ATP 17.6471
17 1IR3 ANP 17.6471
18 3PLS ANP 19.1275
19 4WNP 3RJ 20.2091
20 4WNP 3RJ 20.2091
21 6F3G CJN 21.0169
22 2VN9 GVD 23.2558
23 2VN9 GVD 23.2558
24 5LXM ADP 34.2105
25 2RIO ADP 36.6359
26 2RIO ADP 36.6359
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