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Receptor
PDB id Resolution Class Description Source Keywords
4LWP 2.35 Å EC: 2.-.-.- CRYSTAL STRUCTURE OF PRMT6-SAH TRYPANOSOMA BRUCEI BRUCEI SAM BINDING DOMAIN ARGININE METHYLATION TRANSFERASE
Ref.: CRYSTAL STRUCTURE OF ARGININE METHYLTRANSFERASE 6 F TRYPANOSOMA BRUCEI PLOS ONE V. 9 87267 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
IOD B:403;
B:402;
B:401;
B:406;
A:404;
A:402;
A:403;
B:404;
B:405;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
126.904 I [I-]
SAH A:401;
B:407;
Valid;
Valid;
none;
none;
Kd = 45 uM
384.411 C14 H20 N6 O5 S c1nc(...
PGE A:405;
Invalid;
none;
submit data
150.173 C6 H14 O4 C(COC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4LWP 2.35 Å EC: 2.-.-.- CRYSTAL STRUCTURE OF PRMT6-SAH TRYPANOSOMA BRUCEI BRUCEI SAM BINDING DOMAIN ARGININE METHYLATION TRANSFERASE
Ref.: CRYSTAL STRUCTURE OF ARGININE METHYLTRANSFERASE 6 F TRYPANOSOMA BRUCEI PLOS ONE V. 9 87267 2014
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 269 families.
1 4LWP Kd = 45 uM SAH C14 H20 N6 O5 S c1nc(c2c(n....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 237 families.
1 4LWP Kd = 45 uM SAH C14 H20 N6 O5 S c1nc(c2c(n....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 187 families.
1 4LWP Kd = 45 uM SAH C14 H20 N6 O5 S c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAH; Similar ligands found: 211
No: Ligand ECFP6 Tc MDL keys Tc
1 SAH 1 1
2 5X8 0.759494 0.969697
3 A7D 0.734177 0.926471
4 TT8 0.709302 0.970588
5 DSH 0.692308 0.914286
6 SXZ 0.692308 0.916667
7 DTA 0.666667 0.857143
8 3DH 0.662338 0.869565
9 S8M 0.655556 0.901408
10 SFG 0.635294 0.954545
11 SA8 0.62069 0.915493
12 EEM 0.617977 0.890411
13 MTA 0.615385 0.869565
14 SAI 0.613636 0.955882
15 S7M 0.586957 0.916667
16 36A 0.586538 0.90411
17 K15 0.583333 0.878378
18 ADN 0.573333 0.84058
19 RAB 0.573333 0.84058
20 XYA 0.573333 0.84058
21 62X 0.572917 0.855263
22 5CD 0.571429 0.852941
23 0UM 0.5625 0.876712
24 5N5 0.558442 0.84058
25 A4D 0.551282 0.867647
26 SAM 0.537634 0.916667
27 SMM 0.536842 0.88
28 SSA 0.536842 0.712644
29 KB1 0.534653 0.902778
30 A5D 0.532609 0.857143
31 SIB 0.53125 0.928571
32 EP4 0.530864 0.819444
33 DSZ 0.530612 0.732558
34 GSU 0.53 0.752941
35 A 0.529412 0.763158
36 LMS 0.529412 0.694118
37 AMP 0.529412 0.763158
38 5CA 0.525773 0.712644
39 ME8 0.524752 0.8125
40 M2T 0.52439 0.821918
41 6RE 0.523256 0.824324
42 GJV 0.522727 0.813333
43 AAT 0.515789 0.863014
44 LSS 0.515152 0.696629
45 KAA 0.514852 0.727273
46 J7C 0.511364 0.835616
47 A5A 0.510417 0.697674
48 SON 0.505495 0.805195
49 SRP 0.505155 0.805195
50 F0P 0.504505 0.915493
51 54H 0.5 0.681818
52 VMS 0.5 0.681818
53 ADX 0.5 0.694118
54 CA0 0.5 0.769231
55 AMO 0.5 0.805195
56 5AL 0.5 0.779221
57 KH3 0.5 0.866667
58 NVA LMS 0.49505 0.707865
59 AHX 0.49505 0.753086
60 TSB 0.494949 0.689655
61 53H 0.494949 0.674157
62 G5A 0.494737 0.712644
63 ABM 0.494382 0.74359
64 A2D 0.494382 0.74359
65 ZAS 0.494253 0.808219
66 A6D 0.490196 0.759494
67 8QN 0.49 0.779221
68 GEK 0.49 0.956522
69 GAP 0.489583 0.769231
70 AN2 0.48913 0.734177
71 A3S 0.48913 0.884058
72 S4M 0.488889 0.831169
73 SRA 0.488636 0.746835
74 LAD 0.485437 0.810127
75 52H 0.484848 0.674157
76 A12 0.483516 0.759494
77 BA3 0.483516 0.74359
78 AP2 0.483516 0.759494
79 NEC 0.483146 0.788732
80 AOC 0.483146 0.842857
81 Y3J 0.481481 0.768116
82 VRT 0.479167 0.861111
83 50T 0.478723 0.734177
84 B4P 0.478261 0.74359
85 ADP 0.478261 0.74359
86 5AS 0.478261 0.655556
87 AP5 0.478261 0.74359
88 A3N 0.477778 0.830986
89 YSA 0.476636 0.712644
90 XAH 0.476636 0.768293
91 0XU 0.473684 0.897059
92 AT4 0.473118 0.7375
93 WAQ 0.471154 0.807692
94 NSS 0.470588 0.712644
95 5AD 0.468354 0.791045
96 AU1 0.468085 0.725
97 M33 0.468085 0.734177
98 MAO 0.467391 0.797468
99 TXA 0.466667 0.759494
100 NB8 0.466667 0.775
101 A3G 0.466667 0.871429
102 3AM 0.465909 0.727273
103 DAL AMP 0.465347 0.779221
104 8X1 0.465347 0.707865
105 A3T 0.463158 0.842857
106 ATP 0.463158 0.74359
107 HEJ 0.463158 0.74359
108 ACP 0.463158 0.746835
109 7D7 0.4625 0.785714
110 LEU LMS 0.461538 0.688889
111 9ZA 0.460784 0.740741
112 9ZD 0.460784 0.740741
113 5FA 0.458333 0.74359
114 AQP 0.458333 0.74359
115 AR6 0.458333 0.766234
116 APC 0.458333 0.759494
117 APR 0.458333 0.766234
118 PRX 0.458333 0.746835
119 F2R 0.457627 0.75
120 IOT 0.456897 0.761905
121 4AD 0.456311 0.794872
122 PAJ 0.456311 0.722892
123 WSA 0.45614 0.72093
124 YAP 0.453704 0.794872
125 8PZ 0.453704 0.712644
126 FA5 0.453704 0.805195
127 ADP PO3 0.453608 0.763158
128 ADV 0.453608 0.782051
129 NVA 2AD 0.453608 0.849315
130 SAP 0.453608 0.728395
131 AGS 0.453608 0.728395
132 RBY 0.453608 0.782051
133 AD9 0.453608 0.725
134 PTJ 0.45283 0.731707
135 MHZ 0.452632 0.797468
136 00A 0.451923 0.740741
137 A3P 0.451613 0.74026
138 YLP 0.451327 0.771084
139 7MD 0.45045 0.768293
140 ALF ADP 0.45 0.707317
141 ADP ALF 0.45 0.707317
142 2VA 0.447917 0.819444
143 OOB 0.446602 0.779221
144 ANP 0.444444 0.725
145 T99 0.444444 0.7375
146 ACQ 0.444444 0.746835
147 TAT 0.444444 0.7375
148 P5A 0.443396 0.719101
149 7D5 0.443182 0.708861
150 A1R 0.442308 0.7625
151 YLC 0.439655 0.790123
152 2AM 0.438202 0.717949
153 DLL 0.438095 0.779221
154 ARG AMP 0.4375 0.759036
155 A22 0.436893 0.734177
156 D3Y 0.436893 0.859155
157 ATF 0.435644 0.716049
158 MYR AMP 0.435185 0.746988
159 80F 0.434426 0.75
160 SO8 0.434343 0.808219
161 OAD 0.433962 0.769231
162 3UK 0.433962 0.769231
163 TAD 0.433628 0.765432
164 25A 0.432692 0.74359
165 6YZ 0.431373 0.746835
166 VO4 ADP 0.431373 0.734177
167 ADP VO4 0.431373 0.734177
168 9SN 0.431193 0.731707
169 TYM 0.431034 0.805195
170 B5V 0.429907 0.759494
171 PR8 0.429907 0.8
172 ADQ 0.428571 0.746835
173 YLB 0.42735 0.771084
174 9K8 0.425926 0.67033
175 1ZZ 0.425926 0.746988
176 FYA 0.425926 0.779221
177 3OD 0.425926 0.769231
178 PPS 0.425743 0.674419
179 MAP 0.423077 0.707317
180 A2P 0.421053 0.727273
181 4YB 0.421053 0.735632
182 9X8 0.420561 0.75
183 ADP BMA 0.420561 0.746835
184 TYR AMP 0.419643 0.794872
185 5SV 0.419048 0.731707
186 3NZ 0.416667 0.824324
187 YLA 0.416667 0.771084
188 8Q2 0.415254 0.688889
189 A3R 0.415094 0.7625
190 B5Y 0.414414 0.75
191 B5M 0.414414 0.75
192 48N 0.413793 0.753086
193 LPA AMP 0.413793 0.768293
194 AYB 0.413223 0.761905
195 ACK 0.413043 0.710526
196 QQY 0.413043 0.696203
197 BIS 0.412844 0.719512
198 JB6 0.412844 0.7625
199 PAP 0.41 0.730769
200 DQV 0.408696 0.75641
201 OVE 0.408602 0.7125
202 AMP DBH 0.40708 0.746835
203 4UV 0.40708 0.75
204 3AD 0.406977 0.852941
205 AF3 ADP 3PG 0.40678 0.743902
206 OMR 0.40678 0.738095
207 LAQ 0.405172 0.768293
208 A A 0.40367 0.74359
209 7C5 0.403509 0.789474
210 7MC 0.403361 0.75
211 4UU 0.4 0.75
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4LWP; Ligand: SAH; Similar sites found with APoc: 772
This union binding pocket(no: 1) in the query (biounit: 4lwp.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 3OFK SAH None
2 2BOS GLA GAL GLC None
3 3NKS FAD 1.3587
4 3E1T FAD 1.3587
5 3Q9T FAY 1.3587
6 1WVG APR 1.39276
7 1OC2 TDX 1.43678
8 1OC2 NAD 1.43678
9 4GLL NAD 1.48368
10 1RPN NDP 1.49254
11 3F8D FAD 1.54799
12 5K4W NAI 1.55763
13 5K4W THR 1.55763
14 3GEG NAD 1.61943
15 5X62 SAH 1.63043
16 3M6W SAM 1.63043
17 3SSO SAH 1.63043
18 1QO8 FAD 1.63043
19 5X68 FAD 1.63043
20 4J36 FAD 1.63043
21 4J36 1HR 1.63043
22 3T31 FAD 1.63043
23 3T31 DCQ 1.63043
24 3NTA FAD 1.63043
25 3NT6 FAD 1.63043
26 2B9W FAD 1.63043
27 1E5Q NDP 1.63043
28 3LU1 NAD 1.64835
29 4FZV SAM 1.67364
30 1XHL NDP 1.6835
31 1M1B SPV 1.69492
32 1JQD SAH 1.71233
33 2AOT SAH 1.71233
34 1JQD HSM 1.71233
35 1RP0 AHZ 1.76056
36 1XKQ NDP 1.78571
37 4NTC FAD 1.79104
38 6EQS BV8 1.81818
39 6BWL NAD 1.82927
40 5MIT NAP 1.83486
41 5MIT FAD 1.83486
42 5MPT SAH 1.90217
43 1NAA ABL 1.90217
44 1NAA 6FA 1.90217
45 4MIG G3F 1.90217
46 5WGR FAD 1.90217
47 5KMS NAD 1.90217
48 2YVF NAD 1.90217
49 2YVF FAD 1.90217
50 5MZI FYK 1.90217
51 5MZI FAD 1.90217
52 3AYI HCI 1.90217
53 3AYI FAD 1.90217
54 1GTE FAD 1.90217
55 5Y77 FAD 1.90217
56 5HXI FAD 1.90217
57 5HXI 5HN 1.90217
58 2XVF FAD 1.90217
59 5KMS FAD 1.90217
60 1UWK URO 1.90217
61 1UWK NAD 1.90217
62 4YKG FAD 1.90217
63 4YKG NAD 1.90217
64 3GWZ SAH 1.90217
65 3GXO SAH 1.90217
66 3GMB FAD 1.90217
67 1PJS NAD 1.90217
68 1I8T FAD 1.90736
69 2WYV NAD 1.91571
70 3WMX NAD 1.95531
71 5NA1 FAD 1.96078
72 4YUW 4JU 1.97368
73 4YUW S4M 1.97368
74 3FPF TNA 2.01342
75 3FPF MTA 2.01342
76 4Q9N NAI 2.01342
77 2XYQ SAH 2.06897
78 2DPM SAM 2.11268
79 1NJR XYL 2.11268
80 1XCL SAH 2.12766
81 3ZV6 NAD 2.13523
82 3ZV6 4HB 2.13523
83 4MO2 FDA 2.17391
84 4B63 ORN 2.17391
85 4B63 NAP 2.17391
86 4B63 FAD 2.17391
87 4MO2 FAD 2.17391
88 4BJZ P3A 2.17391
89 4BJZ FAD 2.17391
90 2XVE FAD 2.17391
91 2GV8 FAD 2.17391
92 4EMI FAD 2.17391
93 4EMI NAD 2.17391
94 2GVC FAD 2.17391
95 1GY8 NAD 2.17391
96 3LAD FAD 2.17391
97 4K26 SFF 2.17391
98 4K26 NDP 2.17391
99 2B4Q NAP 2.17391
100 1T90 NAD 2.17391
101 2C5A GDC 2.17391
102 2C5A NAD 2.17391
103 4EIP FAD 2.17391
104 5W7R 9Z7 2.17391
105 2HIM ASN 2.23464
106 4ONQ SFG 2.2409
107 5E9W SAH 2.24359
108 1FL2 FAD 2.25806
109 2O07 SPD 2.30263
110 2O07 MTA 2.30263
111 3WGT QSC 2.30548
112 3WGT FAD 2.30548
113 1ELI PYC 2.31362
114 1N2X SAM 2.32558
115 4JNA FAD 2.35294
116 2EJU SAH 2.44565
117 3GD4 FAD 2.44565
118 3GD4 NAD 2.44565
119 4XQC NAD 2.44565
120 4XQC 13D 2.44565
121 1RYI GOA 2.44565
122 1RYI FAD 2.44565
123 4BV6 FAD 2.44565
124 3ICT FAD 2.44565
125 5BUK FAD 2.44565
126 3ICS FAD 2.44565
127 4IV9 FAD 2.44565
128 3ICR FAD 2.44565
129 2WPF FAD 2.44565
130 6FP4 E1T 2.44565
131 6FP4 FAD 2.44565
132 2WPF WPF 2.44565
133 4RSL FAD 2.44565
134 2NVK FAD 2.44565
135 3ICT ADP 2.44565
136 4DSG FAD 2.44565
137 4DSG UDP 2.44565
138 5JWC FAD 2.44565
139 5Z2L NDP 2.44898
140 5EOW FAD 2.46914
141 4G5H UD7 2.47934
142 4G5H NAP 2.47934
143 1P1C SAH 2.51256
144 1BDB NAD 2.52708
145 4FC7 NAP 2.52708
146 4FC7 COA 2.52708
147 3A4T SFG 2.55474
148 4ZRN UPG 2.5641
149 4ZRN NAD 2.5641
150 1QH9 LAC 2.58621
151 5DM1 SAH 2.62172
152 5DM1 5D7 2.62172
153 1G55 SAH 2.62391
154 1U7T TDT 2.68199
155 1E3W NAD 2.68199
156 1U7T NAD 2.68199
157 1E6W NAD 2.69231
158 3KCC CMP 2.69231
159 1XSE NDP 2.71186
160 6F97 FAD 2.71739
161 2VVM FAD 2.71739
162 4D7E FAD 2.71739
163 2VVL FAD 2.71739
164 3L9W AMP 2.71739
165 4D04 NAP 2.71739
166 4D04 FAD 2.71739
167 3L9W GSH 2.71739
168 5GSN NAP 2.71739
169 5GSN FAD 2.71739
170 6F7L FAD 2.71739
171 2RH4 EMO 2.71739
172 5GSN MMZ 2.71739
173 1BZL GCG 2.71739
174 2Q1W NAD 2.71739
175 1BZL FAD 2.71739
176 6EL3 NAP 2.71739
177 1UDY CS8 2.71739
178 2IZ1 ATR 2.71739
179 1RLZ NAD 2.71739
180 2Q46 NAP 2.7668
181 1TPY SAH 2.78746
182 4J1Q NDP 2.80172
183 3GU3 SAH 2.8169
184 5XLX SAH 2.83688
185 2AG5 NAD 2.84553
186 1XG5 NAP 2.86738
187 5TWB FAD 2.90698
188 2ZE3 AKG 2.90909
189 1AE1 NAP 2.9304
190 1ODJ GMP 2.97872
191 3S5W FAD 2.98913
192 3NYC IAR 2.98913
193 3NYC FAD 2.98913
194 1D4D FAD 2.98913
195 6GAS FAD 2.98913
196 4AP3 NAP 2.98913
197 4AP3 FAD 2.98913
198 2JB2 PHE 2.98913
199 2JB2 FAD 2.98913
200 2RAB NAD 2.98913
201 2RAB FAD 2.98913
202 1MO9 FAD 2.98913
203 1MO9 KPC 2.98913
204 3G5S FAD 2.98913
205 2E5V FAD 2.98913
206 1KNR FAD 2.98913
207 1FEC FAD 2.98913
208 5EZ7 FAD 2.98913
209 1D4D SIN 2.98913
210 3RFV NAI 2.99625
211 3RFV 15L 2.99625
212 4USR FAD 3.04709
213 4RDI ATP 3.125
214 5FTW SAH 3.125
215 4RDH AMP 3.125
216 4J7U YTZ 3.125
217 4J7U NAP 3.125
218 4KGD TDP 3.15091
219 4KGD FAD 3.15091
220 1S7G APR 3.16206
221 3G89 SAM 3.21285
222 2EFJ SAH 3.26087
223 4N49 SAM 3.26087
224 5BVA FAD 3.26087
225 4K5S PM0 3.26087
226 4K5S FAD 3.26087
227 2CDU FAD 3.26087
228 5G3U ITW 3.26087
229 5G3U FDA 3.26087
230 2CDU ADP 3.26087
231 5MLR GRQ 3.26087
232 5MLR NAP 3.26087
233 2GMH FAD 3.26087
234 1PR9 NAP 3.27869
235 3D3W NAP 3.27869
236 1Q7B NAP 3.27869
237 1RJD SAM 3.29341
238 1YXM ADE 3.30033
239 5THQ NDP 3.30882
240 1W8D NAP 3.31126
241 1W73 NAP 3.31126
242 3LZW NAP 3.31325
243 3LZW FAD 3.31325
244 5Y1G AKB 3.35366
245 5Y1G NAD 3.35366
246 4YAC NAI 3.367
247 3FPZ AHZ 3.37423
248 3C3Y SAH 3.37553
249 5CIC 51R 3.40136
250 1ZEM NAD 3.43511
251 3RKR NAP 3.43511
252 2CUL FAD 3.44828
253 3ZNN FAD 3.45821
254 3ZNN 4WL 3.45821
255 3TKA SAM 3.45821
256 3BGD SAH 3.46154
257 3BGD PM6 3.46154
258 1Q0S SAH 3.4749
259 4ZJS 4P0 3.47826
260 1TDF FAD 3.48101
261 3CH6 311 3.4965
262 3CH6 NAP 3.4965
263 4UP3 FAD 3.50318
264 3S1S SAH 3.53261
265 3C6K SPD 3.53261
266 3C6K MTA 3.53261
267 3NDJ JHZ 3.53261
268 3NDJ SAH 3.53261
269 4HA6 FAD 3.53261
270 3AXB PRO 3.53261
271 3AXB FAD 3.53261
272 2IVD FAD 3.53261
273 5FJN BE2 3.53261
274 5FJN FAD 3.53261
275 2YG3 FAD 3.53261
276 3UOY NAP 3.53261
277 3UOY FAD 3.53261
278 5OC1 FAD 3.53261
279 5VN0 FAD 3.53261
280 5VN0 NAI 3.53261
281 6ER9 NAP 3.53261
282 6ER9 FAD 3.53261
283 5JAQ NAI 3.53261
284 5DF1 NAP 3.53261
285 5DF1 58X 3.53261
286 3LXD FAD 3.53261
287 3FG2 FAD 3.53261
288 5XNC MTA 3.53261
289 1X87 NAD 3.53261
290 1YBH FAD 3.53261
291 2WSB NAD 3.54331
292 2UYQ SAM 3.54839
293 3ITJ FAD 3.5503
294 5ZW3 SAH 3.55556
295 4M73 SAH 3.56083
296 4M73 M72 3.56083
297 3P9C SAH 3.57143
298 4ZCC NAI 3.57143
299 4ZCC FAD 3.57143
300 3SJ7 NDP 3.57143
301 4NBU NAI 3.6
302 4USQ FAD 3.60111
303 3EVF GTA 3.61011
304 3EVF SAH 3.61011
305 5A3B APR 3.63036
306 4O0L NDP 3.63636
307 1RKX NAD 3.64146
308 4X7Y SAH 3.64964
309 1RRC ADP 3.65448
310 1QAN SAH 3.68852
311 4EMJ FAD 3.73832
312 1ORR NAD 3.7464
313 3A4V PYR 3.78549
314 3A4V NAD 3.78549
315 4RPL FAD 3.80435
316 4RPL 3UC 3.80435
317 2RGO FAD 3.80435
318 4FWE FAD 3.80435
319 5JCA FAD 3.80435
320 4OPC FDA 3.80435
321 4OPC PGT 3.80435
322 5JCA NDP 3.80435
323 3OZ2 FAD 3.80435
324 2RGH FAD 3.80435
325 5X7Q GLC GLC GLC GLC 3.80435
326 5X7Q GLC GLC GLC 3.80435
327 4LHD GLY 3.80435
328 4OHU 2TK 3.80623
329 4OHU NAD 3.80623
330 2Q0L FAD 3.85852
331 6CI9 NAP 3.861
332 3AB1 FAD 3.88889
333 4OBW SAM 3.89105
334 3QPB URA 3.90071
335 4Y9D NAI 3.93443
336 3SJU NDP 3.94265
337 1V35 NAI 3.95137
338 1ZBQ NAD 3.97554
339 3HB5 NAP 3.97554
340 5L53 NAP 4.01235
341 3G2O SAM 4.01338
342 4X9M FAD 4.06699
343 1GZ6 NAI 4.07523
344 1Y8Q ATP 4.07609
345 3QVP FAD 4.07609
346 6D6Y SAH 4.07609
347 4TM3 FAD 4.07609
348 5KOX FAD 4.07609
349 5KOX RFP 4.07609
350 4Z24 FAD 4.07609
351 4CNK FAD 4.07609
352 2GN4 NDP 4.07609
353 2GN4 UD1 4.07609
354 5YB7 FAD 4.07609
355 5YB7 ORN 4.07609
356 6DEN G8A 4.07609
357 6DEN FAD 4.07609
358 6DEN TP9 4.07609
359 2A8X FAD 4.07609
360 6GNC FAD 4.08163
361 2PX8 SAH 4.08922
362 3QJ4 FAD 4.09357
363 1KYZ SAH 4.10959
364 1KYZ FER 4.10959
365 1UAY ADN 4.13223
366 3WDM ADN 4.21456
367 2ZAT NAP 4.23077
368 3LCC SAH 4.25532
369 3OID NDP 4.26357
370 3HDY GDU 4.34783
371 3HDY FDA 4.34783
372 3HDY FAD 4.34783
373 2JHP SAH 4.34783
374 3SQP FAD 4.34783
375 1RSG FAD 4.34783
376 3GF4 UPG 4.34783
377 4MOP 2H5 4.34783
378 1YY5 FAD 4.34783
379 3GF4 FAD 4.34783
380 3K7M FAD 4.34783
381 6F9Q NAD 4.41176
382 3NUG NAD 4.45344
383 5A9A UTP 4.52675
384 2DTX BMA 4.54545
385 2ZXI FAD 4.55259
386 2Q7V FAD 4.61538
387 4C3Y FAD 4.61957
388 4C3Y ANB 4.61957
389 4M52 FAD 4.61957
390 5EJ2 NAD 4.61957
391 4M52 M52 4.61957
392 5XWV NDP 4.6371
393 5XWV 8H6 4.6371
394 5FFF NAP 4.66926
395 2PK3 A2R 4.6729
396 1ZK7 FAD 4.71092
397 3CBG SAH 4.74138
398 1KYQ NAD 4.74453
399 4O1M NAD 4.7619
400 6FDF SAH 4.79042
401 1LVL NAD 4.80349
402 1LVL FAD 4.80349
403 2EWM NAD 4.81928
404 1UI0 URA 4.87805
405 5DLY SAH 4.88722
406 5DLY 5D7 4.88722
407 5HSA FAS 4.8913
408 5MBX SP5 4.8913
409 5MBX FAD 4.8913
410 1Q9I FAD 4.8913
411 1Q9I TEO 4.8913
412 3X0V FAD 4.8913
413 4XFR CIT 4.8913
414 1T9D P25 4.8913
415 1T9D 1MM 4.8913
416 1T9D PYD 4.8913
417 1T9D FAD 4.8913
418 2BD0 NAP 4.91803
419 5GWX SAM 4.92958
420 5GWX SAR 4.92958
421 1NFQ NAI 5
422 5GWT SIN 5.03597
423 5GWT NAD 5.03597
424 3MB5 SAM 5.09804
425 1GET NAP 5.11111
426 1GET FAD 5.11111
427 4FN4 NAD 5.11811
428 6GKV SAH 5.12821
429 2YY7 NAD 5.12821
430 5JJR SAH 5.16304
431 3TKY SAH 5.16304
432 3GCZ SAM 5.16304
433 1COY FAD 5.16304
434 1COY AND 5.16304
435 3CGB FAD 5.16304
436 5EB4 FAD 5.16304
437 3NTD FAD 5.16304
438 1Q1R FAD 5.16304
439 5TTJ FAD 5.16304
440 2WET FAD 5.16304
441 2OBF SAH 5.19031
442 2OBF F83 5.19031
443 4YAG NAI 5.19031
444 2JAP NDP 5.26316
445 2JAH NDP 5.26316
446 1R18 SAH 5.28634
447 4QTU SAM 5.28846
448 4D42 NAP 5.31915
449 4D42 W0I 5.31915
450 2FR1 NDP 5.34979
451 1GEE NAD 5.36398
452 2ZIF SAM 5.38721
453 3GDH SAH 5.39419
454 6DUB SAH 5.40541
455 3I53 SAH 5.43478
456 2IID FAD 5.43478
457 2IID PHE 5.43478
458 4EUE NAI 5.43478
459 3GDN FAD 5.43478
460 3GDN HBX 5.43478
461 3CGD COA 5.43478
462 3CGD FAD 5.43478
463 1V59 FAD 5.43478
464 1E1M NAP 5.43478
465 1E1M FAD 5.43478
466 2QA1 FAD 5.43478
467 3CGD NAD 5.43478
468 1V59 NAD 5.43478
469 5U8U FAD 5.43478
470 2AQJ FAD 5.43478
471 2AQJ TRP 5.43478
472 4U8P UDP 5.43478
473 4U8P FDA 5.43478
474 5K7U SAM 5.44413
475 1E6E FAD 5.46875
476 1VQW FAD 5.47046
477 1VL0 NAI 5.47945
478 3DXY SAM 5.50459
479 4NTD FAD 5.58824
480 4QED NAP 5.64516
481 2WK1 SAH 5.67376
482 1NNU NAD 5.67686
483 1NNU TCT 5.67686
484 2ZWA SAH 5.70652
485 2R4J FAD 5.70652
486 2R4J 13P 5.70652
487 2Z3Y F2N 5.70652
488 3RNM FAD 5.70652
489 2F5Z FAD 5.70652
490 2NPX FAD 5.70652
491 2NPX NAD 5.70652
492 2V6G NAP 5.76923
493 5Z75 NAD 5.8104
494 4R6W PC 5.81395
495 4R6W SAH 5.81395
496 2P41 SAH 5.90164
497 3PT9 SAH 5.97826
498 4DCM SAM 5.97826
499 5J5Z FAD 5.97826
500 4DMG SAM 5.97826
501 1PN0 FAD 5.97826
502 1PN0 IPH 5.97826
503 2Q1S NAI 5.97826
504 5YJI 8WO 5.98592
505 5YJI SAH 5.98592
506 2GDZ NAD 5.99251
507 3ELW SAM 6
508 3ELW GP3 6
509 3FZG SAM 6
510 1Z3C SA8 6.04027
511 5K0A FAD 6.06061
512 2B4R NAD 6.08696
513 2B4R AES 6.08696
514 3KO8 NAD 6.08974
515 1KEW NAD 6.09418
516 4J56 FAD 6.14035
517 4YRY FAD 6.15942
518 2WA2 SAM 6.15942
519 4YRY NAD 6.15942
520 3OJF NDP 6.22568
521 3TN7 NJP 6.22568
522 3OJF IMJ 6.22568
523 3QOX SAH 6.25
524 5THY SAH 6.25
525 2RGJ FAD 6.25
526 5NMX FAD 6.25
527 5NMX NAP 6.25
528 2C7G FAD 6.25
529 2C7G ODP 6.25
530 1GEG NAD 6.25
531 4JDR FAD 6.25
532 1JNR FAD 6.25
533 1SB8 NAD 6.25
534 1SB8 UD2 6.25
535 4RF7 ARG 6.25
536 1WG8 SAM 6.31579
537 5IL1 SAM 6.33333
538 1XDS SAM 6.41711
539 5ODQ FAD 6.42857
540 2BZG SAH 6.46552
541 1PS9 FAD 6.52174
542 3V1U NAD 6.52174
543 2AE2 PTO 6.53846
544 2AE2 NAP 6.53846
545 3EVG SAH 6.54545
546 1IM8 SAI 6.55738
547 5J60 FAD 6.5625
548 3AFN NAP 6.58915
549 6GAR FAD 6.59026
550 1VE3 SAM 6.60793
551 4NBW NAD 6.61479
552 4I5I NAD 6.62021
553 1W6U NAP 6.62252
554 1I1N SAH 6.63717
555 5E1M SAH 6.639
556 5E1M PRO PRO LYS ARG ILE ALA 6.639
557 4AT0 FAD 6.66667
558 1NV8 SAM 6.69014
559 1NV8 MEQ 6.69014
560 5O2Z FLC 6.72269
561 3K6V CIT 6.77966
562 3KLJ FAD 6.79348
563 5THZ SAH 6.79348
564 5BRT FAD 6.79348
565 5BRT CH9 6.79348
566 1I2B USQ 6.79348
567 1I2B NAD 6.79348
568 1I2B UPG 6.79348
569 3SZB I1E 6.79348
570 1QZZ SAM 6.79348
571 5NII FAD 6.79612
572 3O7W SAM 6.80272
573 5FEU NAP 6.87285
574 5MW4 5JU 6.88623
575 2XOC ADP 6.89655
576 1G60 SAM 6.92308
577 4IWN GEK 6.9869
578 1BXK NAD 7.04225
579 4REP FAD 7.06522
580 5BJX NAD 7.10383
581 5BJX UDP 7.10383
582 5CUQ NSC 7.11611
583 1IY8 NAD 7.11611
584 1R6D NAD 7.12166
585 1R6D DAU 7.12166
586 2PT9 2MH 7.16511
587 2PT9 S4M 7.16511
588 3O03 NAP 7.2165
589 4URF NAD 7.25806
590 5T2U NAP 7.25806
591 3EGI ADP 7.28155
592 1JA9 NDP 7.29927
593 3W9F I3P 7.30769
594 1KPG SAH 7.31707
595 1H82 FAD 7.33696
596 1H82 GZZ 7.33696
597 4A6D SAM 7.33696
598 5YEC ATP 7.35294
599 1UDB UFG 7.39645
600 1UDB NAD 7.39645
601 2NXE SAM 7.48031
602 1VDC FAD 7.50751
603 4YJK URA 7.53968
604 5JCM FAD 7.6087
605 5JCM ISD 7.6087
606 5JCM NAD 7.6087
607 4BLW AMP 7.61246
608 4BLW SAH 7.61246
609 1KPH SAH 7.66551
610 3HVJ 705 7.69231
611 1OAA OAA 7.72201
612 1LSS NAD 7.85714
613 2PZM UDP 7.87879
614 2PZM NAD 7.87879
615 5ERG SAM 7.88043
616 4AZW SAM 7.88043
617 1YQZ FAD 7.88043
618 3UCL CYH 7.88043
619 3UCL FAD 7.88043
620 3UCL NAP 7.88043
621 4HXY NDP 7.88043
622 1EFV AMP 7.93651
623 1EFV FAD 7.93651
624 4GUS FAD 8.06452
625 4GUT FAD 8.06452
626 4HSU FAD 8.06452
627 3VYW SAM 8.11688
628 3FUU ADN 8.11808
629 2I7C AAT 8.12721
630 3QWI CUE 8.14815
631 3QWI NAP 8.14815
632 3VSE SAH 8.15217
633 5TS5 FAD 8.15217
634 4TXI FAD 8.15217
635 2BRY FAD 8.15217
636 6FK3 PPI 8.15217
637 6B92 SAH 8.16327
638 4CQM NAP 8.19672
639 5EEH SAH 8.24468
640 5EEH P9P 8.24468
641 2HMT NAI 8.33333
642 4PIO SAH 8.35913
643 4PIO AVI 8.35913
644 4YNU LGC 8.42391
645 4YNU FAD 8.42391
646 5UAO FAD 8.42391
647 6DNT NAD 8.43023
648 3DUW SAH 8.52018
649 3GUZ PAF 8.52273
650 4II2 ATP 8.58896
651 5WP5 SAH 8.69565
652 1REO FAD 8.69565
653 4D79 ATP 8.69565
654 1XHC FAD 8.71935
655 2A14 SAH 8.74525
656 2FK8 SAM 8.80503
657 1DL5 SAH 8.83281
658 3DMH GMP 8.96739
659 3DMH SAM 8.96739
660 5WP4 SAH 8.96739
661 5KOK SAH 8.96739
662 5KOK S9T 8.96739
663 6H3O FAD 8.96739
664 5KOK R9T 8.96739
665 4UCI SAM 8.96739
666 3A25 SAM 8.9701
667 1H5Q NAP 9.0566
668 3MAG SAH 9.12052
669 3GRU AMP 9.15254
670 1EK6 UPG 9.1954
671 1EK6 NAI 9.1954
672 2JJQ SAH 9.23913
673 2HQM FAD 9.23913
674 3IHG FAD 9.23913
675 3A28 NAD 9.30233
676 2VT3 ATP 9.30233
677 5L95 AMP 9.319
678 5MGZ SAH 9.32203
679 3MCT SAH 9.42761
680 3TLJ SAH 9.51087
681 2XVM SAH 9.54774
682 2Y6Q FAD 9.54774
683 2Y6Q I7T 9.54774
684 6GFK SAH 9.56175
685 5M58 SAH 9.56522
686 6AIN FAD 9.56938
687 3U4C NDP 9.60854
688 1NW5 SAM 9.71787
689 3AD8 NAD 9.78261
690 3AD8 FAD 9.78261
691 3AD8 PYC 9.78261
692 6FHO FAD 9.78261
693 2PD4 NAD 9.81818
694 2PD4 DCN 9.81818
695 1G0N NDP 9.89399
696 1G0N PHH 9.89399
697 4KXQ APR 10
698 1N5D NDP 10.0694
699 1JQ3 AAT 10.1351
700 3H8V ATP 10.274
701 3VC1 GST 10.5769
702 3VC1 SAH 10.5769
703 5W7M SAH 10.5769
704 5W7K SAH 10.5769
705 5N0J FAD 10.5978
706 3JWH SAH 10.5991
707 1EDO NAP 10.6557
708 1VL8 NAP 10.8614
709 3FRH SAH 11.0672
710 1WY7 SAH 11.1111
711 5GVR LMR 11.1111
712 2DKH 3HB 11.1413
713 2DKH FAD 11.1413
714 6BQ6 TER 11.1782
715 3QFA FAD 11.2069
716 3CTY FAD 11.2853
717 1JG3 ADN 11.4894
718 5WUW NAP 11.4983
719 5YF1 8V0 11.6022
720 5YF1 SFG 11.6022
721 2YX1 SFG 11.6071
722 5ICE 2H4 11.6477
723 5ICE SAH 11.6477
724 5HJM MTA 11.9318
725 2PWY SAH 12.4031
726 4POO SAM 12.5
727 1BC5 SAH 12.6394
728 2EG5 SAH 12.7717
729 1ZQ9 SAM 12.9825
730 5O42 BGC 13.587
731 5O42 NAD 13.587
732 5O42 9JW 13.587
733 2YVJ FAD 13.7615
734 1EJ0 SAM 13.8889
735 1L1E SAH 13.9373
736 4ITU 1HS 14.1264
737 4ITU NAI 14.1264
738 4K90 MLA 14.1304
739 2BGM NAJ 14.3885
740 3WV8 ATP 14.6789
741 1QKQ MAN 14.7887
742 1U2Z SAH 16.3043
743 2PXX SAH 16.7442
744 2VDV SAM 17.0732
745 3RJ5 NAD 18.5039
746 3A27 SAM 19.1176
747 2GAG NAD 19.837
748 2GAG FAD 19.837
749 2GAG FOA 19.837
750 4X60 3XV 20.9239
751 4X60 SFG 20.9239
752 4C4A SAH 21.7391
753 3Q87 SAM 24.8
754 4M37 SAH 25.656
755 4XUC 43G 25.6881
756 4XUC SAM 25.6881
757 5E8J SAH 27.2727
758 4GQB 0XU 31.8182
759 3X0D SAH 32.8804
760 4M38 SAH 33.3333
761 5FA5 MTA 35
762 5FWA J7C 42.3913
763 5FUB SAH 42.73
764 4Y30 SAH 44.4444
765 4Y30 49L 44.4444
766 6ARJ BW4 45.8453
767 6ARJ SAH 45.8453
768 5DX8 SFG 45.8453
769 5DWQ SFG 45.8453
770 5DXA SFG 45.8453
771 5DX1 SFG 45.8453
772 5DX0 SFG 45.8453
Pocket No.: 2; Query (leader) PDB : 4LWP; Ligand: SAH; Similar sites found with APoc: 44
This union binding pocket(no: 2) in the query (biounit: 4lwp.bio1) has 20 residues
No: Leader PDB Ligand Sequence Similarity
1 3KL3 GCU 1.3587
2 1Z45 NAD 1.90217
3 5Y77 KYN 1.90217
4 5OVK NDP 1.95312
5 5OJ7 AR6 2.0979
6 5OJI ISN 2.30769
7 5OJI NAP 2.30769
8 3ICS ADP 2.44565
9 2DKN NAI 2.7451
10 1C0I FAD 2.75482
11 1C0I BE2 2.75482
12 3VZS NAP 3.11284
13 1S7G NAD 3.16206
14 1Z6Z NAP 3.19149
15 5I39 FAD 3.26087
16 5ZBC FAD 3.26087
17 3NJ4 NAD 3.26087
18 5L4S 6KX 3.45912
19 5L4S NAP 3.45912
20 2C31 ADP 3.53261
21 1ZK4 NAP 3.58566
22 1ZK4 AC0 3.58566
23 1DSS NAD 3.6036
24 1YC5 NCA 3.65854
25 2BSA NAP 3.9604
26 3ABI NAD 4.10959
27 5FFF 5XC 4.66926
28 5WKC FAD 4.8913
29 5UR0 NAD 5.15759
30 3GFB NAD 5.42857
31 3H9E NAD 5.49133
32 2Q28 ADP 5.70652
33 4L2I FAD 5.78035
34 2FKA BEF 6.20155
35 1FK8 NAD 6.22568
36 3V1Y NAD 6.82493
37 4Z0H NAD 6.88623
38 2CFC NAD 7.2
39 1GPE FAD 7.33696
40 4YSX FAD 8.97436
41 4D86 ADP 11.1413
42 3CIF NAD 11.1421
43 3CIF G3H 11.1421
44 4ZA2 NAD 11.8577
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