Receptor
PDB id Resolution Class Description Source Keywords
4K5Z 1.8 Å EC: 3.4.21.39 CRYSTAL STRUCTURE OF HUMAN CHYMASE IN COMPLEX WITH FRAGMENT 6-CHLORO-2,3-DIHYDRO-1H-ISOINDOL-1-ONE HOMO SAPIENS SERINE PROTEASE GLYCOSYLATED MAST CELLS SECRETED HYDROLAHYDROLASE INHIBITOR COMPLEX
Ref.: DISCOVERY OF POTENT, SELECTIVE CHYMASE INHIBITORS V FRAGMENT LINKING STRATEGIES. J.MED.CHEM. V. 56 4465 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
1P7 A:703;
Valid;
none;
submit data
167.592 C8 H6 Cl N O c1cc2...
ZN A:702;
Part of Protein;
none;
submit data
65.409 Zn [Zn+2...
NAG A:701;
Invalid;
none;
submit data
221.208 C8 H15 N O6 CC(=O...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3N7O 1.8 Å EC: 3.4.21.39 X-RAY STRUCTURE OF HUMAN CHYMASE IN COMPLEX WITH SMALL MOLEC INHIBITOR. HOMO SAPIENS SERINE PROTEASE HYDROLASE
Ref.: POTENCY VARIATION OF SMALL-MOLECULE CHYMASE INHIBIT ACROSS SPECIES. BIOCHEM. PHARMACOL. V. 80 1033 2010
Members (9)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4K60 ic50 = 570 uM 1P8 C8 H6 Br N O c1cc2c(cc1....
2 1T31 Ki = 2.3 nM OHH C40 H35 N2 O6 P CN(C1CCN(C....
3 4K5Z - 1P7 C8 H6 Cl N O c1cc2c(cc1....
4 3N7O Ki = 72 nM N7O C19 H15 Cl F2 N O3 P S C[P@@](=O)....
5 3S0N ic50 = 180 nM 0BB C21 H20 N2 O3 S Cc1cccc2c1....
6 5YJM Kd = 0.000000064 M 8W3 C30 H32 Cl N5 O6 CC[C@H](c1....
7 4K2Y ic50 = 470 uM ES2 C8 H6 Cl N O c1cc2c(cc1....
8 5YJP ic50 = 0.24 uM 8W6 C26 H31 Cl N4 O6 CC[C@H](c1....
9 4K69 ic50 = 0.04 uM 1P9 C22 H22 Br N3 O4 CCC[C@@H](....
70% Homology Family (9)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4K60 ic50 = 570 uM 1P8 C8 H6 Br N O c1cc2c(cc1....
2 1T31 Ki = 2.3 nM OHH C40 H35 N2 O6 P CN(C1CCN(C....
3 4K5Z - 1P7 C8 H6 Cl N O c1cc2c(cc1....
4 3N7O Ki = 72 nM N7O C19 H15 Cl F2 N O3 P S C[P@@](=O)....
5 3S0N ic50 = 180 nM 0BB C21 H20 N2 O3 S Cc1cccc2c1....
6 5YJM Kd = 0.000000064 M 8W3 C30 H32 Cl N5 O6 CC[C@H](c1....
7 4K2Y ic50 = 470 uM ES2 C8 H6 Cl N O c1cc2c(cc1....
8 5YJP ic50 = 0.24 uM 8W6 C26 H31 Cl N4 O6 CC[C@H](c1....
9 4K69 ic50 = 0.04 uM 1P9 C22 H22 Br N3 O4 CCC[C@@H](....
50% Homology Family (468)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1V2V Ki = 427 uM BEN C7 H8 N2 [H]/N=C(c1....
2 2ZDN - 49U C21 H30 N4 O2 [H]/N=C(c1....
3 2ZQ1 - 11U C21 H31 N5 O2 [H]/N=C(/c....
4 1TNH Ki = 0.43 mM FBA C7 H9 F N c1cc(ccc1C....
5 2BYA - BAM C7 H9 N2 c1ccc(cc1)....
6 6SV0 - BEN C7 H8 N2 [H]/N=C(c1....
7 1Y5A Ki = 1.33 uM TL2 C20 H22 N4 O4 [H]/N=C(c1....
8 5MNG - BAM C7 H9 N2 c1ccc(cc1)....
9 6SW0 - BEN C7 H8 N2 [H]/N=C(c1....
10 2AYW - ONO C28 H31 N5 O6 CC(C)(C)[C....
11 6SV9 - BEN C7 H8 N2 [H]/N=C(c1....
12 6SVR - BEN C7 H8 N2 [H]/N=C(c1....
13 1Y3Y Ki = 2300 nM UIR C27 H30 N4 O3 c1cc(ccc1[....
14 3PTB - BEN C7 H8 N2 [H]/N=C(c1....
15 5FXL - BEN C7 H8 N2 [H]/N=C(c1....
16 1O2I Ki = 0.052 uM 655 C19 H20 N4 O2 c1cc(c(c(c....
17 1GI6 Ki = 1.7 uM 124 C15 H14 N3 O c1ccc(c(c1....
18 5MON Kd = 3.3 mM 2AP C5 H7 N2 c1cc[nH+]c....
19 1O3D Ki = 0.074 uM 780 C20 H16 N4 O c1ccc(cc1)....
20 5F6M - BEN C7 H8 N2 [H]/N=C(c1....
21 1Y59 Ki = 1.19 uM TL1 C20 H22 N4 O4 c1cc(cc(c1....
22 1O39 Ki = 0.074 uM 780 C20 H16 N4 O c1ccc(cc1)....
23 1QL7 Kd = 15 uM ZEN C25 H27 Cl N4 O3 S c1cc(cc2c1....
24 2ZDM - 46U C21 H30 N4 O3 [H]/N=C(/c....
25 3NK8 - JKZ C9 H8 F3 N O C1CC2=C(C1....
26 1C2I - BAK C17 H16 N8 O c1cc2c(cc1....
27 1C2E - BAK C17 H16 N8 O c1cc2c(cc1....
28 1G3C Ki = 1.6 uM 109 FE 109 n/a n/a
29 1YP9 Ki = 7700 nM UIZ C31 H32 N4 O3 [H]/N=C(/c....
30 6B6T - BEN C7 H8 N2 [H]/N=C(c1....
31 1V2L Ki = 51 uM BEN C7 H8 N2 [H]/N=C(c1....
32 1Y3X Ki = 7315 nM UIB C26 H32 N4 O3 CC[C@@H]1[....
33 1OYQ Ki = 110 nM T87 C29 H31 N7 O3 [H]/N=C(/c....
34 6SY3 Ki = 497 uM LXW C26 H28 N4 O2 c1ccc(cc1)....
35 1XUG Ki = 0.09 uM BAB C17 H19 N8 c1cc2c(cc1....
36 3AAU Ki = 9 uM GZC CU n/a n/a
37 1C5S Ki = 1 uM ESX C9 H9 N2 S c1ccc2c(c1....
38 1V2N Ki = 1.25 uM BBA C23 H28 N4 O c1cc(ccc1C....
39 1XUH - BAO C17 H14 N8 O c1cc2c(cc1....
40 2G8T - MI2 C16 H15 N3 [H]/N=C(c1....
41 2BY8 - BAM C7 H9 N2 c1ccc(cc1)....
42 5MN1 Kd = 3.3 mM 2AP C5 H7 N2 c1cc[nH+]c....
43 1XUK Ki = 19 uM BAB C17 H19 N8 c1cc2c(cc1....
44 1V2J Ki = 566 uM BEN C7 H8 N2 [H]/N=C(c1....
45 5EG4 Ki = 21 nM 5N7 C42 H56 N10 O6 S [H]/N=C(c1....
46 6SVJ - BEN C7 H8 N2 [H]/N=C(c1....
47 1K1N Kd = 153 nM CCR C29 H39 N5 O7 S Cc1cc(c(c(....
48 1V2M Ki = 51 uM BEN C7 H8 N2 [H]/N=C(c1....
49 1C1T - BAB C17 H19 N8 c1cc2c(cc1....
50 1G3E Ki = 4.2 uM 109 C11 H15 N3 O3 C[C@@H](C(....
51 2FX6 Ki = 200 uM 270 C7 H7 N3 C1=CC2=NC(....
52 2ZQ2 Kd = 276 nM 13U C23 H35 N5 O2 [H]/N=C(/c....
53 1MTW - DX9 C26 H28 N4 O3 [H]/N=C(C)....
54 1QA0 - 270 C7 H7 N3 C1=CC2=NC(....
55 1F0T Ki = 1000 nM PR1 C19 H19 N5 O4 S2 c1cc2c(cc(....
56 1O3E Ki = 0.011 uM 696 C21 H17 N3 O c1ccc(cc1)....
57 1AZ8 - IN4 C20 H24 N4 O2 [H]/N=C(c1....
58 1Y3W Ki = 1680 nM UIP C26 H30 N4 O3 CC[C@@H]1[....
59 2BY9 - BAM C7 H9 N2 c1ccc(cc1)....
60 1QB6 Ki = 870 nM 623 C20 H18 F2 N5 O2 [H]/N=C(/c....
61 1O3N - 785 C15 H11 F3 N4 O2 c1cc2c(cc1....
62 3GY3 Kd = 2.36 uM PNT C19 H24 N4 O2 c1cc(ccc1C....
63 3NKK Kd = 20 uM JLZ C8 H9 F N2 [H]/N=C(/c....
64 3GY4 Kd = 8 uM PBZ C7 H10 N3 c1cc(ccc1C....
65 1TNL Ki = 13.3 mM TPA C9 H12 N c1ccc(cc1)....
66 1C2K - ABI C8 H9 N4 c1cc2c(cc1....
67 1V2K Ki = 0.65 uM ZEN C25 H27 Cl N4 O3 S c1cc(cc2c1....
68 1O3J Ki = 0.17 uM 334 C15 H13 Br N4 O Cc1cc(c(c(....
69 2BZA Ki = 1.58 mM ABN C7 H9 N c1ccc(cc1)....
70 2ZDK - 50U C22 H32 N4 O2 [H]/N=C(/c....
71 5MNQ Kd = 3.6 uM J3I C21 H32 N6 O2 [H]/N=C(N)....
72 1C5P Ki = 21 uM BAM C7 H9 N2 c1ccc(cc1)....
73 1K1M Kd = 40 nM FD4 C26 H29 N5 O4 S CC(=O)N1CC....
74 6B6R - BEN C7 H8 N2 [H]/N=C(c1....
75 1MTS - BX3 C27 H30 N4 O3 CC(=N)N1CC....
76 1UTO Kd = 5.32 mM PEA C8 H12 N c1ccc(cc1)....
77 3AAS Ki = 31 uM GUS C11 H14 N4 O3 [H]/N=C(N)....
78 1TNK Ki = 32.5 mM PRA C9 H13 N c1ccc(cc1)....
79 3GY7 Kd = 30 uM BEN C7 H8 N2 [H]/N=C(c1....
80 1O30 Ki = 0.17 uM 693 C24 H17 F N4 O5 c1ccc(c(c1....
81 2BY6 - BAM C7 H9 N2 c1ccc(cc1)....
82 2AGG - SIN ALA ALA PRO LYS n/a n/a
83 6T5W Ki = 47 uM J5K C20 H25 N5 O2 c1ccc(cc1)....
84 3GY5 Kd = 1.8 uM BRN C14 H15 N7 c1cc(ccc1C....
85 1S0R - BEN C7 H8 N2 [H]/N=C(c1....
86 6B6N - BEN C7 H8 N2 [H]/N=C(c1....
87 1C5Q Ki = 0.44 uM ESI C9 H8 I N2 S c1cc2c(cc(....
88 3T25 - BEN C7 H8 N2 [H]/N=C(c1....
89 1GHZ Ki = 16 uM 120 C13 H12 N5 O c1cc2c(cc1....
90 1C5U - ESP C8 H8 N3 S c1cc2cc(sc....
91 1N6X - ABN C7 H9 N c1ccc(cc1)....
92 1O2V Ki = 1.4 uM 847 C18 H13 Br N4 O5 c1cc2c(cc1....
93 1V2Q Ki = 73.62 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
94 6SV8 - BEN C7 H8 N2 [H]/N=C(c1....
95 1TNG Ki = 1.17 mM AMC C7 H16 N C1CCC(CC1)....
96 3T26 - BEN C7 H8 N2 [H]/N=C(c1....
97 6FID - BEN C7 H8 N2 [H]/N=C(c1....
98 5MNO Kd = 143 uM MRZ C6 H13 N3 [H]/N=C(N)....
99 4YTA - BEN C7 H8 N2 [H]/N=C(c1....
100 1GI4 Ki = 0.065 uM 122 C14 H13 N4 O c1ccc(c(c1....
101 1BTY - BEN C7 H8 N2 [H]/N=C(c1....
102 1K1P - MEL C22 H31 N5 O4 c1cc(ccc1C....
103 1V2T Ki = 19.56 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
104 1O3G Ki = 0.011 uM 696 C21 H17 N3 O c1ccc(cc1)....
105 2TIO - BEN C7 H8 N2 [H]/N=C(c1....
106 1C2D Ki = 0.0052 uM BAK C17 H16 N8 O c1cc2c(cc1....
107 1C1R Ki = 0.0235 uM BAI C16 H14 N6 c1ccc2c(c1....
108 1C2H - BAK C17 H16 N8 O c1cc2c(cc1....
109 1O36 Ki = 1.1 uM 607 C24 H19 N5 O5 c1ccc(c(c1....
110 2BY7 - BAM C7 H9 N2 c1ccc(cc1)....
111 3GY8 Kd = 1.8 uM BRN C14 H15 N7 c1cc(ccc1C....
112 5T3H - BEN C7 H8 N2 [H]/N=C(c1....
113 3ITI ic50 = 0.27 uM BRV C8 H4 Br3 N O4 c1(c(c(c(c....
114 2ZFS - 12U C22 H33 N5 O2 [H]/N=C(/c....
115 3GY6 Kd = 1.8 uM BRN C14 H15 N7 c1cc(ccc1C....
116 1O3L - 678 C17 H13 Br N3 O3 c1cc2c(cc1....
117 1BJU Ki = 6.2 uM GP6 C14 H13 Cl N4 O [H]/N=C(c1....
118 1XUJ Ki < 1 nM BOZ C17 H18 N8 O Zn c1cc2c(cc1....
119 1TX7 Ki = 25 uM 4CM C8 H11 N2 O2 P C[P@](=O)(....
120 6B6O - BEN C7 H8 N2 [H]/N=C(c1....
121 3M35 - M35 C25 H20 F4 N4 O3 S CS(=O)(=O)....
122 1MTU - BX3 C27 H30 N4 O3 CC(=N)N1CC....
123 1O32 Ki = 1.8 uM 801 C13 H11 N5 O c1cc(c(nc1....
124 3T27 - BEN C7 H8 N2 [H]/N=C(c1....
125 5LH4 - 6W4 C32 H34 N6 O2 c1ccc(cc1)....
126 1O2Q Ki = 0.021 uM 991 C20 H20 Cl N3 O2 c1cc(c(c(c....
127 1K1J Kd = 28 nM FD2 C27 H30 N4 O5 S [H]/N=C(/c....
128 5MNN - MRZ C6 H13 N3 [H]/N=C(N)....
129 1C1S - BAB C17 H19 N8 c1cc2c(cc1....
130 1QBO Ki = 18 nM 711 C27 H31 N6 O Cc1[nH]c2c....
131 1V2R Ki = 278.96 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
132 1C5R - ESI C9 H8 I N2 S c1cc2c(cc(....
133 6SVV - BEN C7 H8 N2 [H]/N=C(c1....
134 1K1O - IGN C21 H38 N6 O4 C1CCC(CC1)....
135 2ZFT - 10U C20 H29 N5 O2 c1cc(ccc1C....
136 1TIO - BAM C7 H9 N2 c1ccc(cc1)....
137 1V2U Ki = 427 uM BEN C7 H8 N2 [H]/N=C(c1....
138 1MTV - BX3 C27 H30 N4 O3 CC(=N)N1CC....
139 1Y5B Kd = 1.26 uM TL3 C20 H22 N4 O4 c1cc(ccc1C....
140 1G36 Ki = 67 nM R11 C25 H25 N7 [H]/N=C(/c....
141 6SVZ - BEN C7 H8 N2 [H]/N=C(c1....
142 1O2L - 762 C20 H15 Cl N4 O c1ccc(cc1)....
143 1TX8 Ki = 1800 uM AM4 C8 H10 N2 O2 S CS(=O)(=O)....
144 1GI1 Ki = 3.6 uM BMZ C14 H13 N4 O c1ccc(c(c1....
145 1V2W Ki = 97.79 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
146 6SV6 - BEN C7 H8 N2 [H]/N=C(c1....
147 1O3H Ki = 0.05 uM 907 C16 H14 Br N3 O Cc1cc(c(c(....
148 4NCY - BEN C7 H8 N2 [H]/N=C(c1....
149 1O35 - 802 C14 H11 F N4 O c1cc2c(cc1....
150 1PPC Ki = 0.69 uM MID C27 H31 N5 O4 S [H]/N=C(/c....
151 1TNI Ki = 0.1 mM PBN C10 H15 N c1ccc(cc1)....
152 6SVU - BEN C7 H8 N2 [H]/N=C(c1....
153 1V2S Ki = 68 uM BEN C7 H8 N2 [H]/N=C(c1....
154 1LQE Ki = 1507 nM IMA C34 H36 N5 O2 C[N+](C)(C....
155 1O2S Ki = 3.4 uM CR4 C14 H12 N4 O c1ccc(c(c1....
156 1O3M - 785 C15 H11 F3 N4 O2 c1cc2c(cc1....
157 6E5M - CYS THR LYS SER ILE PRO PRO GLN CYS n/a n/a
158 1O2X Ki = 1.4 uM 847 C18 H13 Br N4 O5 c1cc2c(cc1....
159 1O38 Ki = 0.15 uM 653 C22 H22 N5 O c1ccc(cc1)....
160 1G3B Ki = 1.8 uM 108 C11 H15 N3 O3 C[C@@H](C(....
161 1BJV Ki = 13 uM GP8 C20 H18 N4 O2 c1ccc(cc1)....
162 1C1P - BAI C16 H14 N6 c1ccc2c(c1....
163 1C2J - BAK C17 H16 N8 O c1cc2c(cc1....
164 1C2F - BAH C17 H18 N8 O2 c1cc2c(cc1....
165 3LJJ Kd = 300 nM 10U C20 H29 N5 O2 c1cc(ccc1C....
166 1O3I Ki = 0.05 uM 907 C16 H14 Br N3 O Cc1cc(c(c(....
167 1Y3V Ki = 2300 nM UIR C27 H30 N4 O3 c1cc(ccc1[....
168 1UTP Kd = 36 mM PBN C10 H15 N c1ccc(cc1)....
169 2BLV - BEN C7 H8 N2 [H]/N=C(c1....
170 6SVG - BEN C7 H8 N2 [H]/N=C(c1....
171 1TNJ Ki = 11 mM PEA C8 H12 N c1ccc(cc1)....
172 3GY2 Kd = 1.8 uM BRN C14 H15 N7 c1cc(ccc1C....
173 6T0M Ki = 39 uM GOZ C20 H26 N6 O2 c1ccc(cc1)....
174 6B6S - BEN C7 H8 N2 [H]/N=C(c1....
175 1O2P - 972 C18 H19 Cl N4 O2 CC(C)COc1c....
176 1K1I Kd = 264 nM FD1 C26 H28 N4 O5 S [H]/N=C(c1....
177 1GJ6 Ki = 0.23 uM 132 C21 H17 Cl N3 O c1ccc(cc1)....
178 3LJO Kd = 239 nM 11U C21 H31 N5 O2 [H]/N=C(/c....
179 1O2Y Ki = 1.4 uM 847 C18 H13 Br N4 O5 c1cc2c(cc1....
180 6SVN - BEN C7 H8 N2 [H]/N=C(c1....
181 1O31 Ki = 1.8 uM 801 C13 H11 N5 O c1cc(c(nc1....
182 2BY5 - BAM C7 H9 N2 c1ccc(cc1)....
183 1XUI - BAO C17 H14 N8 O c1cc2c(cc1....
184 1C5T Ki = 80 uM ESP C8 H8 N3 S c1cc2cc(sc....
185 1EB2 Ki = 16 nM BPO C28 H28 N4 O3 [H]/N=C(c1....
186 6SVB - BEN C7 H8 N2 [H]/N=C(c1....
187 1O2K Ki = 0.12 uM 656 C18 H20 N4 O2 CC(C)COc1c....
188 5LGO - 6VZ C27 H36 N6 O4 CNC(=O)[C@....
189 1GI0 - BMZ C14 H13 N4 O c1ccc(c(c1....
190 1V2P Ki = 18.45 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
191 1TPS ic50 = 10 nM OSL DLE THR ARG GLU LEU YNM VAL n/a n/a
192 1N6Y - ABN C7 H9 N c1ccc(cc1)....
193 1O34 Ki = 1.8 uM 801 C13 H11 N5 O c1cc(c(nc1....
194 6SUX - BEN C7 H8 N2 [H]/N=C(c1....
195 2ZDL - 45U C20 H28 N4 O3 [H]/N=C(/c....
196 1PPH Ki = 1.2 uM 0ZG C22 H28 N4 O3 S [H]/N=C(/c....
197 2G5N - 23M C16 H15 N3 [H]/N=C(c1....
198 1G3D Ki = 2.8 uM 108 C11 H15 N3 O3 C[C@@H](C(....
199 5MOO Kd = 48.5 mM WOT C6 H8 N c1ccc(cc1)....
200 1O2U Ki = 1.4 uM 847 C18 H13 Br N4 O5 c1cc2c(cc1....
201 1O2R - CR9 C21 H23 F N4 O2 C[C@H]1CCC....
202 3QK1 - BEN C7 H8 N2 [H]/N=C(c1....
203 6SVX - BEN C7 H8 N2 [H]/N=C(c1....
204 5MNH Kd = 20.7 uM BAM C7 H9 N2 c1ccc(cc1)....
205 6B6P - BEN C7 H8 N2 [H]/N=C(c1....
206 3T29 - BEN C7 H8 N2 [H]/N=C(c1....
207 6EAT - CYS THR LYS SER ILE PRO PRO GLN CYS n/a n/a
208 1O2H Ki = 0.068 uM CR3 C20 H21 N3 O2 c1cc(c(c(c....
209 1QB9 Ki = 36 nM 806 C31 H31 N5 O [H]/N=C(/C....
210 2BLW - BEN C7 H8 N2 [H]/N=C(c1....
211 1O3B Ki = 0.074 uM 780 C20 H16 N4 O c1ccc(cc1)....
212 1O2Z Ki = 0.78 uM 312 C25 H20 N4 O6 COc1ccccc1....
213 1K1L Kd = 125 nM FD3 C24 H27 N5 O3 S [H]/N=C(/c....
214 1O2O Ki = 0.44 uM 950 C18 H19 F N4 O2 CC(C)COc1c....
215 1C1Q - BAI C16 H14 N6 c1ccc2c(c1....
216 1F0U Ki = 69 nM RPR C27 H30 N4 O3 C[C@H]([C@....
217 1C2G - BAH C17 H18 N8 O2 c1cc2c(cc1....
218 1O37 Ki = 0.15 uM 653 C22 H22 N5 O c1ccc(cc1)....
219 1O3F Ki = 0.011 uM 696 C21 H17 N3 O c1ccc(cc1)....
220 1JIR - AML C5 H13 N CCCCCN
221 1O2N Ki = 0.81 uM 762 C20 H15 Cl N4 O c1ccc(cc1)....
222 1O3O - 785 C15 H11 F3 N4 O2 c1cc2c(cc1....
223 1CE5 Ki = 18.4 uM BEN C7 H8 N2 [H]/N=C(c1....
224 5MNB Kd = 3.3 mM 2AP C5 H7 N2 c1cc[nH+]c....
225 6DZF - BEN C7 H8 N2 [H]/N=C(c1....
226 5LH8 - 6WH C31 H38 N6 O3 COc1cc(ccc....
227 2ZHD - 12U C22 H33 N5 O2 [H]/N=C(/c....
228 1O2J Ki = 0.12 uM 656 C18 H20 N4 O2 CC(C)COc1c....
229 1AQ7 ic50 = 0.9 uM 34H DIL XPR AG2 n/a n/a
230 1O3K Ki = 0.17 uM 334 C15 H13 Br N4 O Cc1cc(c(c(....
231 2G5V - 22M C16 H15 N3 [H]/N=C(c1....
232 1Y5U Kd = 0.22 uM TL4 C20 H22 N4 O4 c1cc(cc(c1....
233 6SVI - BEN C7 H8 N2 [H]/N=C(c1....
234 1J8A - BEN C7 H8 N2 [H]/N=C(c1....
235 6B6Q - BEN C7 H8 N2 [H]/N=C(c1....
236 1QB1 Ki = 170 nM 974 C28 H27 F2 N6 O5 Cn1ccnc1c2....
237 1O2W Ki = 1.4 uM 847 C18 H13 Br N4 O5 c1cc2c(cc1....
238 1XUF Ki = 0.09 uM BAZ C17 H16 N8 Zn [H]/N=C(c1....
239 1QBN Ki = 1400 nM 688 C22 H17 N5 O5 c1cc(cc(c1....
240 1O33 Ki = 1.8 uM 801 C13 H11 N5 O c1cc(c(nc1....
241 1V2O Ki = 18.45 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
242 1C1N - BAM C7 H9 N2 c1ccc(cc1)....
243 1UTN Kd = 0.321 mM ABN C7 H9 N c1ccc(cc1)....
244 6SVD - BEN C7 H8 N2 [H]/N=C(c1....
245 6T0P Ki = 62 uM M6Q C20 H25 N5 O2 c1ccc(cc1)....
246 6SVW - BEN C7 H8 N2 [H]/N=C(c1....
247 4NA8 Ki = 1.5 nM 1T6 C31 H28 N4 O3 [H]/N=C(/c....
248 5WB6 Ki = 0.02 nM 9ZM C31 H26 Cl F N10 O4 COC(=O)Nc1....
249 5Q0H Ki = 12 nM 9F1 C27 H26 Cl F2 N5 O4 Cc1cc(c(c(....
250 5TKT Ki = 3.2 nM 7DS C28 H26 Cl N9 O4 COC(=O)Nc1....
251 4CRG - J4X C22 H18 N6 O [H]/N=C(c1....
252 5EXL Ki = 3.7 nM 5SS C28 H31 N5 O2 c1ccc(cc1)....
253 6TS5 ic50 = 0.003 uM NW2 C27 H29 N O5 CC(C)c1cc(....
254 6VLU Ki = 149.1 nM R2Y C27 H37 F2 N5 O2 CC(C)C[C@H....
255 5E2O Ki = 2 nM 5JM C26 H21 Cl N6 O4 c1ccc(cc1)....
256 4CRB Ki = 0.027 uM 7P0 C28 H24 Cl N7 O4 c1ccc(cc1)....
257 6TS6 ic50 = 0.004 uM NW5 C27 H26 N2 O4 CC(C)(C#N)....
258 5TKS Ki = 68 nM 7DL C29 H30 Cl2 N8 O3 COC(=O)Nc1....
259 5QTY Ki = 2.5 nM QLJ C32 H33 Cl N8 O5 CCOC(=O)[C....
260 5Q0E Ki = 0.69 nM 9FD C29 H30 Cl N9 O4 C[C@H]1CCC....
261 4CRE - MVN C10 H8 Cl N O CC1=CC(=O)....
262 4CRA Ki = 0.06 uM XJ8 C29 H25 N5 O4 c1ccc(cc1)....
263 1ZHR - BEN C7 H8 N2 [H]/N=C(c1....
264 5E2P Ki = 1.6 nM 7P0 C28 H24 Cl N7 O4 c1ccc(cc1)....
265 3BG8 - BEN C7 H8 N2 [H]/N=C(c1....
266 4X6P Ki = 5 nM 3YU C28 H23 Cl N10 O c1ccc(cc1)....
267 5Q0D Ki = 1 nM 9EY C27 H26 Cl N9 O4 COC(=O)Nc1....
268 4X6O Ki = 1.9 nM 3Y4 C29 H26 Cl2 N8 O3 COC(=O)Nc1....
269 5EXN Ki = 23 nM 5SU C31 H26 Cl N7 O3 COC(=O)Nc1....
270 4CR9 Ki = 80 uM OTW C10 H11 N3 Cc1cc(nc2c....
271 6TS4 ic50 = 2.8 uM J7B C22 H20 N2 O3 c1ccc(c(c1....
272 6USY Ki = 0.0004 uM QGS C28 H28 N2 O4 CC(C)c1cc(....
273 4CRC Ki = 0.0019 uM OTM C26 H21 Cl N10 O2 c1ccc(cc1)....
274 5QCL Ki = 11 nM BUY C27 H21 Cl N6 O4 c1ccc2c(c1....
275 1ZHM - BEN C7 H8 N2 [H]/N=C(c1....
276 5EXM Ki = 6.3 nM 5ST C29 H34 N4 O3 COC(=O)Nc1....
277 4TY7 Ki = 0.3 nM 39F C26 H30 Cl N7 O c1ccc(cc1)....
278 5QTT Ki = 3.4 nM QEY C30 H29 Cl F N7 O4 C[C@@H]1CC....
279 6W50 Ki = 0.3 nM SWP C31 H29 Cl F2 N4 O4 C[C@@H]1CC....
280 5QQP Ki = 5.3 nM NR7 C29 H30 Cl N5 O4 COC(=O)Nc1....
281 6C0S Ki = 89 nM EEJ C31 H31 Cl2 N9 O4 CC(=O)N1CC....
282 4CRF Ki = 0.0005 uM R9B C29 H23 Cl N4 O5 c1ccc(cc1)....
283 5QCN Ki = 6 nM BVM C36 H34 Cl N7 O7 CCOC(=O)[C....
284 6VLV Ki = 5.33 nM R3A C19 H25 Cl N6 O4 S [H]/N=C(/N....
285 5QTV Ki = 1.1 nM QLS C28 H27 Cl F3 N9 O3 COC(=O)Nc1....
286 4X6M Ki = 5.8 nM 3Y3 C27 H26 Cl2 N8 O c1ccc(cc1)....
287 5QTW Ki = 0.46 nM QLM C29 H30 Cl N9 O5 COC(=O)[C@....
288 4CR5 Ki = 70 uM 0TU C9 H6 Cl N O c1cc2c(cc1....
289 4CRD Ki = 0.08 uM OTJ C22 H22 Cl2 N8 O3 COC(=O)Nc1....
290 5QCM Ki = 110 nM BVJ C28 H23 Cl F N7 O4 COC(=O)Nc1....
291 5NB6 ic50 = 0.5 uM 8S2 C22 H21 F3 N6 O4 c1ccc2c(c1....
292 6FTY - E7H C20 H24 N4 O2 c1cc2c(cc(....
293 6QMR ic50 = 0.012 uM J6T C23 H23 N O4 c1ccc(c(c1....
294 5NAW ic50 = 0.05 uM 8RZ C23 H20 F3 N5 O4 c1ccc2c(c1....
295 5MT0 Kd ~ 500 uM QJS C19 H15 F N2 O3 c1ccc(cc1)....
296 6FUG Kd = 50 uM E85 C18 H17 N7 O c1cc(cc(c1....
297 5NAR ic50 = 0.5 uM 8RW C22 H20 F3 N5 O4 c1ccc2c(c1....
298 5FBE ic50 = 14 uM 5W5 C22 H22 F3 N3 O5 COC(=O)c1c....
299 6FUH Kd = 170 uM E88 C20 H23 N5 O2 CC(C)[C@@H....
300 5FBI Kd = 1600 uM 5WD C17 H14 N2 O4 c1cc(cc(c1....
301 6QMT ic50 = 0.12 uM J7B C22 H20 N2 O3 c1ccc(c(c1....
302 6FUT Kd = 20 uM E82 C24 H24 N2 O c1ccc2c(c1....
303 6FUJ ic50 = 120 uM E8B C18 H22 N2 O CC(C)CC(=O....
304 5FCK Kd = 0.006 uM 5WC C23 H22 Cl F N6 O3 C[C@H](c1c....
305 5NB7 ic50 = 0.006 uM 8NQ C21 H19 Br N6 O3 c1ccc2c(c1....
306 5MT4 Kd ~ 500 uM M7O C15 H14 N2 O3 c1ccc(cc1)....
307 5NBA ic50 = 0.05 uM 8S5 C22 H19 F4 N5 O4 c1ccc2c(c1....
308 6FUI Kd = 35 uM E7W C22 H25 N5 O2 c1ccc2c(c1....
309 6FTZ Kd = 1000 uM E7E C17 H16 N4 O2 c1cc(cc(c1....
310 6A8N Ki = 6.8 nM CYS PRO ALA TYR SER ARG TYR ILE GLY CYS n/a n/a
311 1ELC - 0Z3 C26 H34 F3 N4 O3 CC(C)c1ccc....
312 1ELD Ki = 0.2 uM 0Z0 C21 H19 F6 N3 O3 NULL
313 7EST - 0Z2 C18 H21 F6 N3 O3 CC(C)C[C@@....
314 2BD4 - LYS TYR PRO PHE VAL GLU PRO ILE n/a n/a
315 1ELB Ki = 70 nM 0Z4 C23 H36 F3 N4 O3 CC(C)C[C@@....
316 6TH7 ic50 = 1.18 nM O4Q 5XU ABA ILE ABA VAL N9K PHA AA4 n/a n/a
317 1ELE Ki = 0.14 uM 0QN C17 H19 F6 N3 O3 NULL
318 4GVU ic50 = 30 nM 6NA GLN THR DBU GLJ PHE YNM VAL n/a n/a
319 1NES - ACE ALA PRO ALA n/a n/a
320 2BDB - ALA ALA n/a n/a
321 1BMA Ki = 26 uM 0QH C27 H36 F3 N4 O3 NULL
322 2EST - 2Z5 C18 H23 F6 N4 O3 NULL
323 1ELA Ki = 0.44 uM 0Z1 C22 H32 F3 N4 O3 CC(C)c1ccc....
324 1QR3 ic50 = 0.26 uM ALQ CIR THR DBU GLJ PHE TYJ VAL n/a n/a
325 1BIT - BEN C7 H8 N2 [H]/N=C(c1....
326 1HJ8 - BAM C7 H9 N2 c1ccc(cc1)....
327 1UTL Ka = 293 M^-1 PRA C9 H13 N c1ccc(cc1)....
328 2TBS - BEN C7 H8 N2 [H]/N=C(c1....
329 2ZPQ - BEN C7 H8 N2 [H]/N=C(c1....
330 1UTJ Kd = 0.144 mM ABN C7 H9 N c1ccc(cc1)....
331 1UTM Ka = 243 M^-1 PEA C8 H12 N c1ccc(cc1)....
332 1MBQ - BEN C7 H8 N2 [H]/N=C(c1....
333 2ZPS - BEN C7 H8 N2 [H]/N=C(c1....
334 2ZPR - BEN C7 H8 N2 [H]/N=C(c1....
335 1L2E - BEN C7 H8 N2 [H]/N=C(c1....
336 3VFE - 0HL C26 H26 N4 O4 S3 [H]/N=C(c1....
337 6QH9 - J3B C13 H16 N4 O2 [H]/N=C(/c....
338 6QFH ic50 = 1.38 uM J08 C23 H22 N6 O [H]/N=C(/c....
339 6QHB - J2W C15 H15 N3 O3 [H]/N=C(/c....
340 6SKC - BEN C7 H8 N2 [H]/N=C(c1....
341 1LO6 - BEN C7 H8 N2 [H]/N=C(c1....
342 6QFF ic50 = 2.04 uM J08 C23 H22 N6 O [H]/N=C(/c....
343 6QHC - 135 C14 H13 N3 O2 [H]/N=C(c1....
344 4D8N ic50 = 1.8 uM 0HM C24 H24 N5 O2 c1ccc(cc1)....
345 6QFG ic50 = 3.01 uM J08 C23 H22 N6 O [H]/N=C(/c....
346 6QHA - J2Q C16 H17 N3 O3 [H]/N=C(/c....
347 3P8G - BEN C7 H8 N2 [H]/N=C(c1....
348 1EAX - BEN C7 H8 N2 [H]/N=C(c1....
349 2GV6 Ki = 0.046 uM 730 C28 H35 N7 O3 S [H]/N=C(c1....
350 4R0I Ki = 0.3 uM 3KM C27 H33 N5 O4 S [H]/N=C(c1....
351 4O97 Ki = 3 nM NTX C29 H34 N6 O3 [H]/N=C(N)....
352 2GV7 Ki = 0.014 uM 672 C36 H54 N8 O4 S [H]/N=C(c1....
353 4O9V Ki = 10 nM NT4 C27 H30 N6 O3 [H]/N=C(N)....
354 1IAU Ki = 80 nM ACE ILE GLU PRO ASJ n/a n/a
355 1ANE - BEN C7 H8 N2 [H]/N=C(c1....
356 1J16 Ki = 143 uM BEN C7 H8 N2 [H]/N=C(c1....
357 1J14 Ki = 32.2 uM BEN C7 H8 N2 [H]/N=C(c1....
358 1BRA Ki = 15000 uM BEN C7 H8 N2 [H]/N=C(c1....
359 1J15 Ki = 143 uM BEN C7 H8 N2 [H]/N=C(c1....
360 1TRM - BEN C7 H8 N2 [H]/N=C(c1....
361 1J17 Ki = 6.05 uM ZEN C25 H27 Cl N4 O3 S c1cc(cc2c1....
362 1ANC - BEN C7 H8 N2 [H]/N=C(c1....
363 1QL9 Ki = 4.45 uM ZEN C25 H27 Cl N4 O3 S c1cc(cc2c1....
364 1DPO - BEN C7 H8 N2 [H]/N=C(c1....
365 1AND - BEN C7 H8 N2 [H]/N=C(c1....
366 1W0Z Ki = 21 nM SI1 C18 H29 N5 O5 S [H]/N=C(c1....
367 4ZHL Kd = 0.0147 uM CYS PRO ALA TYR SER ARG TYR ILE GLY CYS n/a n/a
368 2VIV ic50 = 520 nM VG2 C22 H28 Cl N3 O2 Cc1cc(cc(c....
369 1SC8 Ki = 0.036 uM 2IN C20 H25 N5 O5 S c1ccc(cc1)....
370 1OWE Ki = 0.631 uM 675 C18 H15 N3 O [H]/N=C(/c....
371 4X1Q - CYS PRO ALA TYR SER ARG TYR LEU ASP CYS n/a n/a
372 2VIP ic50 = 5.2 uM L1R C18 H20 Cl2 N2 O3 CC(C)Oc1cc....
373 5ZAF Ki = 166 nM 28I C16 H21 N7 O2 [H]/N=C(N)....
374 1SQT Ki = 0.63 uM UI3 C16 H16 N4 O3 S [H]/N=C(/c....
375 1W13 Ki = 2 nM SM1 C21 H28 N6 O5 S [H]/N=C(/N....
376 1OWH Ki = 40 nM 239 C19 H18 N4 O [H]/N=C(/c....
377 1EJN Ki = 2.4 uM AGB C19 H27 N5 O [H]/N=C(/N....
378 4ZHM Kd = 0.00081 uM MRZ CYS PRO ALA TYR SER ALA TYR ILE GLY CYS n/a n/a
379 2VIN ic50 > 1 mM 505 C11 H17 N O Cc1cccc(c1....
380 5ZA8 Ki = 508 nM 27I C16 H23 N9 O [H]/N=C(/N....
381 5ZA7 Ki = 1356 nM HMX C12 H18 Cl N7 O C1CCCN(CC1....
382 4X0W - MRZ CYS PRO ALA TYR SER DAL TYR LEU ASP CYS n/a n/a
383 1U6Q - 745 C20 H18 N2 [H]/N=C(/c....
384 5ZA9 Ki = 183 nM 50I C20 H23 N7 O2 [H]/N=C(/N....
385 2VIQ ic50 = 1.3 uM D55 C21 H28 N2 O4 CCOc1ccc(c....
386 4X1P - CYS PRO ALA TYR SER DAL TYR LEU ASP CYS MRZ n/a n/a
387 6NMB Ki = 2.01 mM AMH C8 H15 N O2 C1CC(CCC1C....
388 5ZAG Ki = 108 nM 94I C16 H21 N9 O [H]/N=C(N)....
389 5ZC5 Ki = 88 nM 09I C20 H22 F N7 O2 [H]/N=C(/N....
390 1VJ9 Ki = 0.028 uM 5IN C28 H33 N5 O6 S c1ccc(cc1)....
391 1F5K Ki = 180 uM BAM C7 H9 N2 c1ccc(cc1)....
392 5ZAE Ki = 156 nM EAU C16 H21 N7 O2 [H]/N=C(/N....
393 1OWD Ki = 6.3 nM 497 C23 H24 N4 O CC[C@H]1CN....
394 2VNT Ki = 9.9 nM QGG C15 H16 Cl N5 O4 S c1cc2c(cc1....
395 2VIO ic50 = 40 uM L1O C9 H9 Cl2 N O3 c1c(cc(c(c....
396 1F5L Ki = 5.3 uM AMR C6 H8 Cl N7 O c1(c(nc(c(....
397 5ZAJ Ki = 42 nM 32I C18 H25 N9 O3 [H]/N=C(/N....
398 2R2W Ki = 34 uM 4PG C15 H15 N3 O [H]/N=C(/N....
399 2VIW ic50 = 72 nM D56 C24 H32 Cl N3 O3 CCOc1c(cc(....
400 1W11 Ki = 6 nM SK1 C21 H27 N5 O5 S [H]/N=C(c1....
401 1SQA Ki = 0.00062 uM UI1 C23 H21 N7 O c1cnc(nc1)....
402 1VJA Ki = 0.02 uM 7IN C21 H27 N5 O6 S c1ccc(cc1)....
403 1SQO Ki = 0.035 uM UI2 C15 H13 N5 c1cc2ccc(c....
404 1GDN - GLY ALA LYS n/a n/a
405 1FY5 - GLY ALA LYS n/a n/a
406 1FY4 - GLY ALA ARG n/a n/a
407 1PQ8 - GLY GLY ARG n/a n/a
408 1FN8 - GLY ALA ARG n/a n/a
409 1PQ7 - ARG C6 H15 N4 O2 C(C[C@@H](....
410 1PQ5 - ARG C6 H15 N4 O2 C(C[C@@H](....
411 1H4W Ki = 22 uM BEN C7 H8 N2 [H]/N=C(c1....
412 5TP0 Ki = 3.66 uM BRN C14 H15 N7 c1cc(ccc1C....
413 1T32 Ki = 38 nM OHH C40 H35 N2 O6 P CN(C1CCN(C....
414 4K60 ic50 = 570 uM 1P8 C8 H6 Br N O c1cc2c(cc1....
415 1T31 Ki = 2.3 nM OHH C40 H35 N2 O6 P CN(C1CCN(C....
416 4K5Z - 1P7 C8 H6 Cl N O c1cc2c(cc1....
417 3N7O Ki = 72 nM N7O C19 H15 Cl F2 N O3 P S C[P@@](=O)....
418 3S0N ic50 = 180 nM 0BB C21 H20 N2 O3 S Cc1cccc2c1....
419 5YJM Kd = 0.000000064 M 8W3 C30 H32 Cl N5 O6 CC[C@H](c1....
420 4K2Y ic50 = 470 uM ES2 C8 H6 Cl N O c1cc2c(cc1....
421 5YJP ic50 = 0.24 uM 8W6 C26 H31 Cl N4 O6 CC[C@H](c1....
422 4K69 ic50 = 0.04 uM 1P9 C22 H22 Br N3 O4 CCC[C@@H](....
423 1OSS Ki = 16.4 uM BEN C7 H8 N2 [H]/N=C(c1....
424 3BEU - BEN C7 H8 N2 [H]/N=C(c1....
425 5XWL - ACE THR ARG GLU n/a n/a
426 5XWJ - ACE THR ARG GLU n/a n/a
427 1V6D - PRO ASP AIB LEU AIB LEU ALA TBF NME n/a n/a
428 1YF4 Ki = 5 nM CYS TYR PHE GLN ASN CYS PRO ARG GLY NH2 n/a n/a
429 1S6H - 4BZ C8 H10 N2 O [H]/N=C(c1....
430 1S83 - 4HA C4 H12 N O C(CCO)C[NH....
431 1S5S - PG3 C4 H12 N3 O C(CNC(=[NH....
432 5A09 ic50 = 3.5 nM JJD C23 H18 F3 N3 O4 CC1=C([C@H....
433 5A8X ic50 = 6.5 nM IUY C24 H20 F3 N4 O2 CCOC(=O)C1....
434 5ABW ic50 = 17 nM WQQ C26 H24 Cl N3 O5 S Cc1c(c(on1....
435 5A8Y ic50 = 0.17 nM VBM C23 H16 F3 N7 O2 CC1=C([C@H....
436 5A0B ic50 = 5 nM JJX C29 H29 F3 N6 O2 CC1=C([C@H....
437 5A8Z ic50 = 28 nM IUL C21 H16 F3 N5 O2 CN1CC2=C([....
438 3Q77 ic50 = 6 nM 2HY C22 H18 F3 N3 O4 CC1=C([C@H....
439 5A0C ic50 = 0.54 nM JJV C21 H15 F3 N4 O3 S CC1=C([C@H....
440 5A0A Ki = 15 nM JJS C20 H15 F3 N4 O2 CC1=C([C@H....
441 2AIQ - BEN C7 H8 N2 [H]/N=C(c1....
442 2OQ5 - BEN C7 H8 N2 [H]/N=C(c1....
443 5F03 - 5TA C24 H20 Cl N3 O3 c1cc(cc(c1....
444 2ZA5 Ki = 3.7 nM 2FF C26 H24 N2 O3 c1ccc(cc1)....
445 2FPZ Ki = 110 uM 270 C7 H7 N3 C1=CC2=NC(....
446 2BM2 Ki = 15 nM PM2 C26 H29 N3 O c1ccc(cc1)....
447 3V7T Ki = 62 nM 0GX C23 H28 Br F N2 O2 S CCCOc1c(c(....
448 2ZEB - 11M C23 H24 N2 O2 S2 CSc1c2cccc....
449 4A6L Ki = 10 nM P43 C25 H23 F N2 O2 c1ccc(c(c1....
450 2ZEC - 11N C22 H24 N2 O2 c1ccc(cc1)....
451 4NFE - BEN C7 H8 N2 [H]/N=C(c1....
452 2ANW - BAM C7 H9 N2 c1ccc(cc1)....
453 2ANY - BAM C7 H9 N2 c1ccc(cc1)....
454 5TJX - GBT C29 H33 N7 O3 Cc1c2c(cc(....
455 6O1S - 7SD C23 H25 N7 O Cc1cc(nc(c....
456 6T7P Ki = 0.97 uM MU8 C26 H24 Cl N3 O3 c1ccc(cc1)....
457 6QFE ic50 = 0.08 uM J08 C23 H22 N6 O [H]/N=C(/c....
458 6B74 - BEN C7 H8 N2 [H]/N=C(c1....
459 1A0J - BEN C7 H8 N2 [H]/N=C(c1....
460 2ZGJ - SER SER GLY LYS VAL PRO LEU SER n/a n/a
461 2ZGH - SER SER GLY LYS VAL PRO LEU n/a n/a
462 2BDG - PBZ C7 H10 N3 c1cc(ccc1C....
463 5Y9L ic50 = 1.9 uM 8R3 C24 H28 Cl N5 O5 CN(C)/N=C1....
464 5YJK ic50 = 0.82 uM 8VX C24 H30 Cl N5 O5 S CN(C)/N=C1....
465 5FAH ic50 = 0.7 uM 5VT C26 H29 N3 O3 COc1ccc(cc....
466 3TJV - PRO THR SER TYR ALA GLY ASP ASP SER GLY n/a n/a
467 6AHS ic50 = 1.5 uM 9YO C19 H18 Cl N3 O2 S Cc1ccc2c(c....
468 5ZFI ic50 = 1.2 uM 9C9 C26 H29 Cl2 N7 O2 Cn1cc(cn1)....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 1P7; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 1P7 1 1
2 3Z8 0.5 0.794118
Similar Ligands (3D)
Ligand no: 1; Ligand: 1P7; Similar ligands found: 1222
No: Ligand Similarity coefficient
1 5B1 1.0000
2 CWS 0.9840
3 KUF 0.9836
4 JB5 0.9804
5 ES5 0.9791
6 GTQ 0.9789
7 2AQ 0.9779
8 54G 0.9779
9 2HQ 0.9778
10 4FS 0.9777
11 COU 0.9771
12 03V 0.9770
13 ES9 0.9768
14 5M0 0.9766
15 OCH 0.9764
16 JAE 0.9761
17 SX1 0.9761
18 5RG 0.9757
19 RM1 0.9751
20 11S 0.9747
21 H4N 0.9742
22 5MK 0.9737
23 0P6 0.9736
24 FK1 0.9735
25 5H1 0.9733
26 H42 0.9732
27 5MB 0.9730
28 8CM 0.9725
29 BZX 0.9722
30 5MI 0.9721
31 86J 0.9710
32 14O 0.9710
33 KT7 0.9704
34 F60 0.9703
35 8NY 0.9689
36 6AI 0.9688
37 I3A 0.9684
38 5OB 0.9683
39 Q88 0.9683
40 6CS 0.9682
41 2K4 0.9680
42 BZ3 0.9675
43 BGC 0.9675
44 5XC 0.9671
45 7HQ 0.9666
46 CWM 0.9656
47 GCS 0.9650
48 0RW 0.9649
49 HLR 0.9643
50 9MG 0.9643
51 4CS 0.9641
52 G3F 0.9634
53 8GC 0.9631
54 6M9 0.9626
55 42A 0.9619
56 F05 0.9619
57 LZM 0.9614
58 9EW 0.9610
59 J9T 0.9610
60 N8Y 0.9610
61 5WV 0.9603
62 2EC 0.9600
63 QUZ 0.9599
64 SVN 0.9598
65 GLC 0.9596
66 KKN 0.9595
67 N5J 0.9594
68 F9Y 0.9593
69 ES0 0.9589
70 3Z7 0.9588
71 JPZ 0.9585
72 3NT 0.9584
73 GAB 0.9584
74 2D0 0.9580
75 1LQ 0.9579
76 8S0 0.9578
77 MRW 0.9573
78 9TZ 0.9573
79 4M4 0.9572
80 MR1 0.9569
81 DMD 0.9565
82 4ZC 0.9563
83 7B4 0.9563
84 G3E 0.9562
85 8WT 0.9561
86 MEW 0.9560
87 NPY 0.9558
88 1SQ 0.9557
89 1NP 0.9555
90 5IQ 0.9555
91 MWP 0.9555
92 NMJ 0.9554
93 Q24 0.9552
94 5SG 0.9551
95 7W4 0.9548
96 ISN 0.9547
97 3PF 0.9547
98 4YS 0.9546
99 6M4 0.9546
100 SAL 0.9544
101 JBH 0.9543
102 A7W 0.9542
103 1LM 0.9542
104 XQ0 0.9541
105 WCE 0.9541
106 PE0 0.9540
107 AZ8 0.9540
108 VGD 0.9538
109 OVV 0.9538
110 ES1 0.9537
111 5Q0 0.9534
112 DIN 0.9534
113 3BZ 0.9533
114 5HN 0.9530
115 3AB 0.9528
116 ES7 0.9528
117 O72 0.9528
118 AQO 0.9528
119 EA1 0.9528
120 3ID 0.9528
121 M5K 0.9527
122 LT2 0.9527
123 1DW 0.9527
124 BRT 0.9526
125 HQY 0.9525
126 53C 0.9525
127 ABV 0.9524
128 2CQ 0.9524
129 36R 0.9523
130 3HB 0.9519
131 ADZ 0.9517
132 AZA 0.9515
133 KJU 0.9511
134 1XM 0.9509
135 1P8 0.9506
136 CLW 0.9505
137 9DG 0.9503
138 AHR 0.9503
139 3F0 0.9501
140 PZI 0.9501
141 BHO 0.9497
142 V55 0.9495
143 4HC 0.9492
144 BOA 0.9491
145 YH7 0.9488
146 GUN 0.9485
147 25W 0.9485
148 24W 0.9483
149 QWN 0.9481
150 4JT 0.9480
151 PXL 0.9478
152 ES2 0.9477
153 5QY 0.9475
154 G6D 0.9473
155 AJ2 0.9472
156 KDV 0.9470
157 ISZ 0.9469
158 JA8 0.9467
159 XAN 0.9466
160 JBE 0.9466
161 N2I 0.9466
162 BCP 0.9463
163 1WG 0.9458
164 2BG 0.9457
165 IGA 0.9457
166 4NC 0.9456
167 F0J 0.9455
168 HH8 0.9454
169 150 0.9453
170 D48 0.9453
171 B60 0.9452
172 MUA 0.9451
173 MAQ 0.9448
174 XQG 0.9448
175 4XH 0.9447
176 3U4 0.9445
177 R8V 0.9445
178 GAL 0.9445
179 ET2 0.9444
180 A2F 0.9444
181 5VM 0.9443
182 7VS 0.9443
183 QXW 0.9442
184 2AK 0.9441
185 3HA 0.9441
186 J5I 0.9439
187 TTL 0.9439
188 5JC 0.9435
189 FDB 0.9435
190 6GU 0.9434
191 MCT 0.9430
192 JBK 0.9429
193 SE2 0.9429
194 TH7 0.9429
195 DBX 0.9428
196 3M0 0.9427
197 2MI 0.9427
198 M0Q 0.9427
199 6AP 0.9425
200 OVM 0.9424
201 3MB 0.9424
202 NIZ 0.9422
203 MZG 0.9422
204 XIY 0.9422
205 HPA 0.9421
206 OAA 0.9421
207 FBB 0.9420
208 AZG 0.9420
209 BE2 0.9420
210 DHB 0.9419
211 12Q 0.9418
212 MWJ 0.9418
213 AJV 0.9415
214 G5V 0.9415
215 I1E 0.9414
216 DX4 0.9414
217 JND 0.9414
218 K2T 0.9413
219 0CU 0.9413
220 DIU 0.9412
221 8ZE 0.9412
222 DBH 0.9410
223 1XN 0.9409
224 AX7 0.9409
225 M1A 0.9406
226 NDM 0.9406
227 ADE 0.9405
228 0JD 0.9404
229 CTL 0.9404
230 E7Z 0.9403
231 UAN 0.9403
232 4YO 0.9402
233 ES6 0.9402
234 FE DB1 0.9400
235 7W1 0.9398
236 270 0.9397
237 32X 0.9397
238 5GU 0.9397
239 CFI 0.9397
240 KOJ 0.9396
241 HMH 0.9394
242 INO 0.9394
243 MWM 0.9394
244 F4Z 0.9394
245 SKA 0.9393
246 BTE 0.9392
247 IV2 0.9392
248 IND 0.9392
249 BEZ 0.9392
250 2YU 0.9391
251 HA5 0.9391
252 0TU 0.9390
253 1PT 0.9390
254 4SV 0.9389
255 45C 0.9388
256 UNC 0.9388
257 4JP 0.9388
258 HLZ 0.9386
259 HQT 0.9383
260 27Y 0.9380
261 KJH 0.9378
262 C2U 0.9378
263 BEN 0.9378
264 14J 0.9377
265 MQN 0.9377
266 BR9 0.9377
267 290 0.9376
268 RSF 0.9376
269 9DA 0.9375
270 141 0.9375
271 4ZE 0.9375
272 BAM 0.9375
273 TSS 0.9375
274 BZI 0.9373
275 3DO 0.9372
276 APZ 0.9371
277 3R6 0.9371
278 0CT 0.9371
279 4HO 0.9370
280 2CK 0.9369
281 BZF 0.9369
282 XYP 0.9367
283 NOJ 0.9366
284 0FO 0.9365
285 6MP 0.9364
286 4A3 0.9364
287 4XR 0.9364
288 67N 0.9363
289 NCA 0.9362
290 4JQ 0.9360
291 DEN 0.9359
292 5RN 0.9358
293 XX2 0.9357
294 TC7 0.9357
295 9HX 0.9355
296 NNO 0.9355
297 YCP 0.9355
298 EQT 0.9354
299 P9P 0.9353
300 LZ1 0.9352
301 MYJ 0.9351
302 4JJ 0.9349
303 2HO 0.9348
304 R8S 0.9348
305 MLT 0.9348
306 6VD 0.9346
307 HH5 0.9345
308 M1Q 0.9345
309 4CL 0.9344
310 9R5 0.9344
311 CFP 0.9343
312 NBZ 0.9343
313 6PC 0.9343
314 FOT 0.9342
315 EYK 0.9342
316 0R1 0.9339
317 1M2 0.9337
318 4HM 0.9336
319 KBB 0.9335
320 MPI 0.9335
321 2AC 0.9333
322 TH0 0.9333
323 5QX 0.9332
324 FHB 0.9332
325 XBZ 0.9331
326 ICO 0.9328
327 XHP 0.9325
328 QOS 0.9325
329 OTW 0.9324
330 DHQ 0.9324
331 XM0 0.9324
332 HT4 0.9322
333 NIO 0.9322
334 FQI 0.9319
335 93K 0.9318
336 4Z4 0.9318
337 1MC 0.9318
338 GVH 0.9317
339 173 0.9317
340 M1H 0.9317
341 3HM 0.9315
342 PZA 0.9313
343 JZ2 0.9312
344 AC0 0.9312
345 TM7 0.9311
346 IDM 0.9309
347 9TW 0.9307
348 4MU 0.9307
349 URF 0.9307
350 QX4 0.9307
351 7HP 0.9306
352 A1U 0.9306
353 XXR 0.9306
354 92K 0.9304
355 34A 0.9304
356 94W 0.9302
357 JKE 0.9302
358 DRL 0.9300
359 XYD 0.9299
360 44W 0.9297
361 10L 0.9294
362 2MP 0.9294
363 5JQ 0.9294
364 A29 0.9293
365 EUG 0.9293
366 HX3 0.9293
367 CHB 0.9292
368 BEA 0.9289
369 DQU 0.9289
370 BDP 0.9289
371 F31 0.9288
372 5CU 0.9287
373 54D 0.9286
374 Y8I 0.9286
375 E5X 0.9286
376 HQD 0.9285
377 ICP 0.9283
378 PYD 0.9283
379 TPA 0.9281
380 SHA 0.9280
381 B62 0.9280
382 CWJ 0.9279
383 UNU 0.9279
384 LKA 0.9278
385 BCU 0.9276
386 IJZ 0.9275
387 1P3 0.9275
388 URC 0.9274
389 8H8 0.9273
390 717 0.9273
391 23A 0.9270
392 XAZ 0.9269
393 OW4 0.9269
394 AZ9 0.9267
395 75K 0.9267
396 DNF 0.9267
397 NTN 0.9266
398 NPO 0.9266
399 GYE 0.9266
400 NK 0.9264
401 6ME 0.9264
402 3WA 0.9262
403 BP1 0.9260
404 HHA 0.9260
405 WBU 0.9258
406 JFJ 0.9258
407 LGC 0.9257
408 1WD 0.9256
409 MVN 0.9253
410 7WA 0.9252
411 FYU 0.9252
412 5MH 0.9252
413 PM6 0.9251
414 OVP 0.9250
415 7MU 0.9247
416 JXN 0.9246
417 GXY 0.9245
418 5RO 0.9244
419 SHG 0.9244
420 BTY 0.9242
421 SOR 0.9242
422 HIS 0.9242
423 SWD 0.9241
424 TDR 0.9240
425 0R0 0.9238
426 8IG 0.9237
427 5NU 0.9236
428 7WV 0.9236
429 0W8 0.9236
430 LXC 0.9236
431 SXS 0.9235
432 43M 0.9235
433 GOJ 0.9231
434 51R 0.9231
435 F9P 0.9231
436 LDP 0.9230
437 VGL 0.9229
438 FP1 0.9229
439 FBM 0.9228
440 5WX 0.9227
441 XBT 0.9227
442 BSX 0.9226
443 BE7 0.9226
444 0HN 0.9226
445 5JL 0.9226
446 FA0 0.9224
447 B55 0.9223
448 6NT 0.9222
449 DOB 0.9221
450 8W9 0.9221
451 9FL 0.9220
452 R9Y 0.9220
453 3NY 0.9218
454 3IT 0.9218
455 82I 0.9218
456 QSB 0.9212
457 4M0 0.9211
458 1U6 0.9211
459 SOE 0.9211
460 44V 0.9210
461 NDH 0.9209
462 SS1 0.9209
463 KJY 0.9207
464 8TX 0.9205
465 1F1 0.9205
466 VNL 0.9203
467 J9W 0.9201
468 FAN 0.9200
469 M58 0.9199
470 VXX 0.9197
471 ES4 0.9196
472 0HO 0.9196
473 SRO 0.9194
474 M2K 0.9194
475 4ME 0.9194
476 4AA 0.9193
477 M1E 0.9193
478 DBJ 0.9193
479 DYA 0.9193
480 JZ3 0.9192
481 PKU 0.9191
482 15E 0.9191
483 7CZ 0.9191
484 2ZM 0.9189
485 NSP 0.9189
486 MO8 0.9188
487 PBC 0.9187
488 2AL 0.9187
489 QX2 0.9186
490 7NI 0.9186
491 TLD 0.9186
492 TOF 0.9184
493 BHA 0.9184
494 DE5 0.9182
495 JBQ 0.9182
496 0FK 0.9182
497 DGJ 0.9180
498 5UC 0.9177
499 QBK 0.9176
500 QWW 0.9175
501 39O 0.9174
502 ABI 0.9172
503 3OC 0.9172
504 PHB 0.9172
505 AJY 0.9171
506 IHB 0.9171
507 8OZ 0.9170
508 ORO 0.9169
509 34D 0.9168
510 0N7 0.9168
511 JZ9 0.9167
512 HJP 0.9167
513 92P 0.9165
514 GAG 0.9165
515 0TR 0.9165
516 2LY 0.9160
517 2H5 0.9159
518 DPZ 0.9158
519 2HU 0.9155
520 RAM 0.9155
521 WOO 0.9154
522 5WY 0.9154
523 B53 0.9153
524 FUL 0.9153
525 B57 0.9151
526 3XX 0.9151
527 EVA 0.9150
528 9FE 0.9149
529 6RQ 0.9147
530 OXC 0.9147
531 PAB 0.9147
532 JLZ 0.9142
533 MT0 0.9141
534 PH2 0.9139
535 261 0.9139
536 4P5 0.9139
537 JAW 0.9139
538 42C 0.9138
539 XYS 0.9137
540 495 0.9136
541 5NI 0.9136
542 GRE 0.9135
543 24B 0.9135
544 7ME 0.9133
545 E1T 0.9132
546 Q6T 0.9132
547 XCZ 0.9131
548 8HC 0.9131
549 3A9 0.9131
550 QSC 0.9130
551 CFF 0.9128
552 GBD 0.9127
553 AW5 0.9126
554 SWA 0.9126
555 NQ 0.9125
556 7VJ 0.9123
557 L3Q 0.9122
558 UFO 0.9122
559 HZQ 0.9121
560 ALL 0.9121
561 GDE 0.9119
562 IT2 0.9119
563 C2Y 0.9118
564 M6N 0.9117
565 15L 0.9115
566 PRF 0.9115
567 F5B 0.9115
568 Z82 0.9115
569 TIU 0.9114
570 EDR 0.9112
571 7ZE 0.9112
572 JYB 0.9111
573 DHK 0.9111
574 ASO 0.9110
575 GCU 0.9110
576 1IT 0.9108
577 4JO 0.9107
578 9CA 0.9106
579 60P 0.9105
580 VK3 0.9104
581 6NI 0.9104
582 DIE 0.9103
583 D07 0.9100
584 RMN 0.9100
585 ODO 0.9100
586 069 0.9099
587 BK9 0.9099
588 PDC 0.9099
589 PHU 0.9097
590 CTS 0.9097
591 15N 0.9097
592 T6C 0.9097
593 ZBT 0.9097
594 ZZT 0.9096
595 HHR 0.9095
596 HMU 0.9092
597 LMR 0.9090
598 H7Y 0.9090
599 OXQ 0.9090
600 JB8 0.9090
601 1DV 0.9090
602 HY3 0.9090
603 6M1 0.9089
604 AKH 0.9088
605 3FH 0.9088
606 HDH 0.9087
607 FBW 0.9087
608 HBD 0.9087
609 149 0.9084
610 9ZE 0.9083
611 6F0 0.9082
612 XYL 0.9080
613 PFB 0.9079
614 2ZQ 0.9078
615 RXA 0.9078
616 TGX 0.9078
617 FRU 0.9077
618 VNJ 0.9074
619 MS9 0.9074
620 2ZV 0.9071
621 1Y6 0.9069
622 ESI 0.9069
623 EXO 0.9069
624 CLZ 0.9066
625 DOR 0.9066
626 P92 0.9065
627 DHR 0.9064
628 8WO 0.9062
629 LSA 0.9061
630 GVG 0.9061
631 3RK 0.9058
632 174 0.9055
633 J9Q 0.9055
634 HQJ 0.9054
635 IUR 0.9053
636 ISE 0.9053
637 P3K 0.9052
638 FBV 0.9050
639 7B3 0.9047
640 LNR 0.9046
641 PBZ 0.9046
642 QAT 0.9044
643 2PC 0.9044
644 GZ8 0.9042
645 JDN 0.9040
646 PD2 0.9040
647 39A 0.9038
648 97T 0.9038
649 PQ0 0.9037
650 MXN 0.9036
651 F12 0.9036
652 7MH 0.9036
653 2LP 0.9035
654 4FA 0.9035
655 DEE 0.9034
656 HBA 0.9034
657 SKM 0.9033
658 PEY 0.9031
659 268 0.9030
660 35C 0.9030
661 GM7 0.9028
662 JIF 0.9028
663 0F9 0.9027
664 PEA 0.9027
665 AC6 0.9026
666 TTY 0.9026
667 GCB 0.9026
668 NID 0.9025
669 PYQ 0.9024
670 OK7 0.9023
671 PRZ 0.9022
672 PNZ 0.9022
673 2A9 0.9020
674 2FG 0.9020
675 GJS 0.9019
676 ZYR 0.9019
677 EKZ 0.9019
678 GLA 0.9019
679 42J 0.9018
680 SYV 0.9017
681 826 0.9016
682 YIO 0.9016
683 TP5 0.9015
684 SLS 0.9013
685 4MA 0.9013
686 PBA 0.9012
687 TBP 0.9010
688 OA3 0.9010
689 0XT 0.9009
690 JUG 0.9009
691 2FQ 0.9009
692 K34 0.9008
693 S76 0.9007
694 J1Z 0.9006
695 RHU 0.9006
696 IFL 0.9006
697 GIO 0.9005
698 SJ5 0.9004
699 SRT 0.8998
700 5CL 0.8998
701 EN1 0.8996
702 ADK 0.8994
703 3MA 0.8994
704 3SK 0.8992
705 RNS 0.8992
706 2A7 0.8990
707 X05 0.8990
708 37T 0.8990
709 TT4 0.8990
710 DFU 0.8989
711 PYC 0.8989
712 IDH 0.8989
713 L99 0.8988
714 D1X 0.8988
715 FGZ 0.8987
716 P72 0.8987
717 KBG 0.8987
718 GTR 0.8987
719 G1O 0.8985
720 PRO 0.8985
721 BMA 0.8985
722 GZL 0.8985
723 IFP 0.8984
724 FUC 0.8984
725 PCA 0.8983
726 TEP 0.8983
727 RIP 0.8983
728 QAS 0.8981
729 4TU 0.8980
730 INE 0.8980
731 M0W 0.8980
732 PHH 0.8979
733 FOA 0.8979
734 G2F 0.8978
735 RSO 0.8978
736 EV0 0.8977
737 0W1 0.8977
738 BZ2 0.8977
739 1KP 0.8976
740 4ZA 0.8976
741 NVU 0.8976
742 4WL 0.8975
743 SW7 0.8973
744 X0V 0.8973
745 RIB 0.8971
746 4VP 0.8970
747 FUD 0.8969
748 AEF 0.8969
749 8G0 0.8968
750 ASC 0.8967
751 URP 0.8966
752 GCO 0.8966
753 C21 0.8965
754 OMD 0.8965
755 B5D 0.8964
756 INS 0.8964
757 KTW 0.8961
758 JG8 0.8960
759 ANN 0.8960
760 RB5 0.8958
761 BSP 0.8957
762 HXX 0.8957
763 VOH 0.8957
764 IF7 0.8954
765 QSH 0.8954
766 L5V 0.8953
767 1A7 0.8953
768 0MK 0.8953
769 G4D 0.8952
770 K5W 0.8951
771 F81 0.8948
772 23J 0.8948
773 7MX 0.8946
774 JBN 0.8945
775 AKG 0.8945
776 XRG 0.8941
777 28N 0.8941
778 APG 0.8941
779 IWT 0.8940
780 X09 0.8940
781 265 0.8939
782 IAC 0.8938
783 ABE 0.8937
784 FB1 0.8937
785 275 0.8936
786 URA 0.8936
787 RCO 0.8935
788 AMC 0.8935
789 4FH 0.8932
790 TZC 0.8931
791 4XV 0.8929
792 258 0.8928
793 3CH 0.8928
794 3BU 0.8927
795 CRS 0.8926
796 12B 0.8925
797 4VS 0.8924
798 MBG 0.8924
799 284 0.8923
800 OTR 0.8922
801 2FY 0.8921
802 A13 0.8921
803 1GN 0.8920
804 DTL 0.8919
805 6LW 0.8918
806 1DU 0.8917
807 KYD 0.8916
808 GIV 0.8915
809 2DR 0.8913
810 3DM 0.8912
811 SMV 0.8912
812 GLT 0.8911
813 7WR 0.8909
814 SYN 0.8908
815 4BZ 0.8907
816 286 0.8906
817 TWO 0.8905
818 ARB 0.8905
819 TSU 0.8904
820 4SX 0.8904
821 95Z 0.8904
822 QPR 0.8901
823 ZWZ 0.8900
824 TBS 0.8900
825 FCA 0.8900
826 259 0.8900
827 EOL 0.8896
828 LG3 0.8896
829 HIO 0.8895
830 IBF 0.8895
831 20J 0.8892
832 YRL 0.8890
833 LG5 0.8889
834 0FN 0.8889
835 E7S 0.8888
836 Q7A 0.8886
837 DA4 0.8885
838 DFB 0.8885
839 ESX 0.8881
840 DMJ 0.8880
841 282 0.8880
842 4JM 0.8880
843 GXL 0.8879
844 K17 0.8878
845 CYT 0.8878
846 EJZ 0.8877
847 BBF 0.8877
848 ROI 0.8877
849 BCF 0.8876
850 4KL 0.8876
851 NOY 0.8876
852 PY7 0.8876
853 3SL 0.8876
854 HHQ 0.8874
855 F4E 0.8873
856 X6X 0.8873
857 IPB 0.8872
858 HFB 0.8871
859 YSO 0.8870
860 273 0.8870
861 B3R 0.8869
862 HKD 0.8869
863 2O6 0.8869
864 BVF 0.8868
865 Q71 0.8868
866 52C 0.8867
867 ZVO 0.8866
868 H76 0.8865
869 M4T 0.8864
870 HBX 0.8864
871 GAF 0.8864
872 9KT 0.8863
873 RD4 0.8861
874 26D 0.8860
875 30G 0.8860
876 MAN 0.8859
877 AX3 0.8859
878 4XS 0.8858
879 PYF 0.8857
880 XUL 0.8857
881 5NE 0.8855
882 M3T 0.8854
883 23W 0.8854
884 SVD 0.8854
885 JFD 0.8853
886 HEW 0.8852
887 ONR 0.8852
888 3ZQ 0.8852
889 JAB 0.8851
890 Z5P 0.8850
891 1QP 0.8850
892 JZ5 0.8850
893 ABN 0.8848
894 E35 0.8847
895 JTH 0.8847
896 FCR 0.8847
897 J6W 0.8847
898 FPY 0.8847
899