Receptor
PDB id Resolution Class Description Source Keywords
4K2Y 2.3 Å EC: 3.4.21.39 CRYSTAL STRUCTURE OF HUMAN CHYMASE IN COMPLEX WITH FRAGMENT 6-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE HOMO SAPIENS SERINE PROTEASE GLYCOSYLATED MAST CELLS SECRETED HYDROLAHYDROLASE INHIBITOR COMPLEX
Ref.: DISCOVERY OF POTENT, SELECTIVE CHYMASE INHIBITORS V FRAGMENT LINKING STRATEGIES. J.MED.CHEM. V. 56 4465 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ES2 A:303;
Valid;
none;
ic50 = 470 uM
167.592 C8 H6 Cl N O c1cc2...
NAG A:302;
Invalid;
none;
submit data
221.208 C8 H15 N O6 CC(=O...
ZN A:301;
Part of Protein;
none;
submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3N7O 1.8 Å EC: 3.4.21.39 X-RAY STRUCTURE OF HUMAN CHYMASE IN COMPLEX WITH SMALL MOLEC INHIBITOR. HOMO SAPIENS SERINE PROTEASE HYDROLASE
Ref.: POTENCY VARIATION OF SMALL-MOLECULE CHYMASE INHIBIT ACROSS SPECIES. BIOCHEM. PHARMACOL. V. 80 1033 2010
Members (9)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4K60 ic50 = 570 uM 1P8 C8 H6 Br N O c1cc2c(cc1....
2 1T31 Ki = 2.3 nM OHH C40 H35 N2 O6 P CN(C1CCN(C....
3 4K5Z - 1P7 C8 H6 Cl N O c1cc2c(cc1....
4 3N7O Ki = 72 nM N7O C19 H15 Cl F2 N O3 P S C[P@@](=O)....
5 3S0N ic50 = 180 nM 0BB C21 H20 N2 O3 S Cc1cccc2c1....
6 5YJM Kd = 0.000000064 M 8W3 C30 H32 Cl N5 O6 CC[C@H](c1....
7 4K2Y ic50 = 470 uM ES2 C8 H6 Cl N O c1cc2c(cc1....
8 5YJP ic50 = 0.24 uM 8W6 C26 H31 Cl N4 O6 CC[C@H](c1....
9 4K69 ic50 = 0.04 uM 1P9 C22 H22 Br N3 O4 CCC[C@@H](....
70% Homology Family (9)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4K60 ic50 = 570 uM 1P8 C8 H6 Br N O c1cc2c(cc1....
2 1T31 Ki = 2.3 nM OHH C40 H35 N2 O6 P CN(C1CCN(C....
3 4K5Z - 1P7 C8 H6 Cl N O c1cc2c(cc1....
4 3N7O Ki = 72 nM N7O C19 H15 Cl F2 N O3 P S C[P@@](=O)....
5 3S0N ic50 = 180 nM 0BB C21 H20 N2 O3 S Cc1cccc2c1....
6 5YJM Kd = 0.000000064 M 8W3 C30 H32 Cl N5 O6 CC[C@H](c1....
7 4K2Y ic50 = 470 uM ES2 C8 H6 Cl N O c1cc2c(cc1....
8 5YJP ic50 = 0.24 uM 8W6 C26 H31 Cl N4 O6 CC[C@H](c1....
9 4K69 ic50 = 0.04 uM 1P9 C22 H22 Br N3 O4 CCC[C@@H](....
50% Homology Family (468)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1V2V Ki = 427 uM BEN C7 H8 N2 [H]/N=C(c1....
2 2ZDN - 49U C21 H30 N4 O2 [H]/N=C(c1....
3 2ZQ1 - 11U C21 H31 N5 O2 [H]/N=C(/c....
4 1TNH Ki = 0.43 mM FBA C7 H9 F N c1cc(ccc1C....
5 2BYA - BAM C7 H9 N2 c1ccc(cc1)....
6 6SV0 - BEN C7 H8 N2 [H]/N=C(c1....
7 1Y5A Ki = 1.33 uM TL2 C20 H22 N4 O4 [H]/N=C(c1....
8 5MNG - BAM C7 H9 N2 c1ccc(cc1)....
9 6SW0 - BEN C7 H8 N2 [H]/N=C(c1....
10 2AYW - ONO C28 H31 N5 O6 CC(C)(C)[C....
11 6SV9 - BEN C7 H8 N2 [H]/N=C(c1....
12 6SVR - BEN C7 H8 N2 [H]/N=C(c1....
13 1Y3Y Ki = 2300 nM UIR C27 H30 N4 O3 c1cc(ccc1[....
14 3PTB - BEN C7 H8 N2 [H]/N=C(c1....
15 5FXL - BEN C7 H8 N2 [H]/N=C(c1....
16 1O2I Ki = 0.052 uM 655 C19 H20 N4 O2 c1cc(c(c(c....
17 1GI6 Ki = 1.7 uM 124 C15 H14 N3 O c1ccc(c(c1....
18 5MON Kd = 3.3 mM 2AP C5 H7 N2 c1cc[nH+]c....
19 1O3D Ki = 0.074 uM 780 C20 H16 N4 O c1ccc(cc1)....
20 5F6M - BEN C7 H8 N2 [H]/N=C(c1....
21 1Y59 Ki = 1.19 uM TL1 C20 H22 N4 O4 c1cc(cc(c1....
22 1O39 Ki = 0.074 uM 780 C20 H16 N4 O c1ccc(cc1)....
23 1QL7 Kd = 15 uM ZEN C25 H27 Cl N4 O3 S c1cc(cc2c1....
24 2ZDM - 46U C21 H30 N4 O3 [H]/N=C(/c....
25 3NK8 - JKZ C9 H8 F3 N O C1CC2=C(C1....
26 1C2I - BAK C17 H16 N8 O c1cc2c(cc1....
27 1C2E - BAK C17 H16 N8 O c1cc2c(cc1....
28 1G3C Ki = 1.6 uM 109 FE 109 n/a n/a
29 1YP9 Ki = 7700 nM UIZ C31 H32 N4 O3 [H]/N=C(/c....
30 6B6T - BEN C7 H8 N2 [H]/N=C(c1....
31 1V2L Ki = 51 uM BEN C7 H8 N2 [H]/N=C(c1....
32 1Y3X Ki = 7315 nM UIB C26 H32 N4 O3 CC[C@@H]1[....
33 1OYQ Ki = 110 nM T87 C29 H31 N7 O3 [H]/N=C(/c....
34 6SY3 Ki = 497 uM LXW C26 H28 N4 O2 c1ccc(cc1)....
35 1XUG Ki = 0.09 uM BAB C17 H19 N8 c1cc2c(cc1....
36 3AAU Ki = 9 uM GZC CU n/a n/a
37 1C5S Ki = 1 uM ESX C9 H9 N2 S c1ccc2c(c1....
38 1V2N Ki = 1.25 uM BBA C23 H28 N4 O c1cc(ccc1C....
39 1XUH - BAO C17 H14 N8 O c1cc2c(cc1....
40 2G8T - MI2 C16 H15 N3 [H]/N=C(c1....
41 2BY8 - BAM C7 H9 N2 c1ccc(cc1)....
42 5MN1 Kd = 3.3 mM 2AP C5 H7 N2 c1cc[nH+]c....
43 1XUK Ki = 19 uM BAB C17 H19 N8 c1cc2c(cc1....
44 1V2J Ki = 566 uM BEN C7 H8 N2 [H]/N=C(c1....
45 5EG4 Ki = 21 nM 5N7 C42 H56 N10 O6 S [H]/N=C(c1....
46 6SVJ - BEN C7 H8 N2 [H]/N=C(c1....
47 1K1N Kd = 153 nM CCR C29 H39 N5 O7 S Cc1cc(c(c(....
48 1V2M Ki = 51 uM BEN C7 H8 N2 [H]/N=C(c1....
49 1C1T - BAB C17 H19 N8 c1cc2c(cc1....
50 1G3E Ki = 4.2 uM 109 C11 H15 N3 O3 C[C@@H](C(....
51 2FX6 Ki = 200 uM 270 C7 H7 N3 C1=CC2=NC(....
52 2ZQ2 Kd = 276 nM 13U C23 H35 N5 O2 [H]/N=C(/c....
53 1MTW - DX9 C26 H28 N4 O3 [H]/N=C(C)....
54 1QA0 - 270 C7 H7 N3 C1=CC2=NC(....
55 1F0T Ki = 1000 nM PR1 C19 H19 N5 O4 S2 c1cc2c(cc(....
56 1O3E Ki = 0.011 uM 696 C21 H17 N3 O c1ccc(cc1)....
57 1AZ8 - IN4 C20 H24 N4 O2 [H]/N=C(c1....
58 1Y3W Ki = 1680 nM UIP C26 H30 N4 O3 CC[C@@H]1[....
59 2BY9 - BAM C7 H9 N2 c1ccc(cc1)....
60 1QB6 Ki = 870 nM 623 C20 H18 F2 N5 O2 [H]/N=C(/c....
61 1O3N - 785 C15 H11 F3 N4 O2 c1cc2c(cc1....
62 3GY3 Kd = 2.36 uM PNT C19 H24 N4 O2 c1cc(ccc1C....
63 3NKK Kd = 20 uM JLZ C8 H9 F N2 [H]/N=C(/c....
64 3GY4 Kd = 8 uM PBZ C7 H10 N3 c1cc(ccc1C....
65 1TNL Ki = 13.3 mM TPA C9 H12 N c1ccc(cc1)....
66 1C2K - ABI C8 H9 N4 c1cc2c(cc1....
67 1V2K Ki = 0.65 uM ZEN C25 H27 Cl N4 O3 S c1cc(cc2c1....
68 1O3J Ki = 0.17 uM 334 C15 H13 Br N4 O Cc1cc(c(c(....
69 2BZA Ki = 1.58 mM ABN C7 H9 N c1ccc(cc1)....
70 2ZDK - 50U C22 H32 N4 O2 [H]/N=C(/c....
71 5MNQ Kd = 3.6 uM J3I C21 H32 N6 O2 [H]/N=C(N)....
72 1C5P Ki = 21 uM BAM C7 H9 N2 c1ccc(cc1)....
73 1K1M Kd = 40 nM FD4 C26 H29 N5 O4 S CC(=O)N1CC....
74 6B6R - BEN C7 H8 N2 [H]/N=C(c1....
75 1MTS - BX3 C27 H30 N4 O3 CC(=N)N1CC....
76 1UTO Kd = 5.32 mM PEA C8 H12 N c1ccc(cc1)....
77 3AAS Ki = 31 uM GUS C11 H14 N4 O3 [H]/N=C(N)....
78 1TNK Ki = 32.5 mM PRA C9 H13 N c1ccc(cc1)....
79 3GY7 Kd = 30 uM BEN C7 H8 N2 [H]/N=C(c1....
80 1O30 Ki = 0.17 uM 693 C24 H17 F N4 O5 c1ccc(c(c1....
81 2BY6 - BAM C7 H9 N2 c1ccc(cc1)....
82 2AGG - SIN ALA ALA PRO LYS n/a n/a
83 6T5W Ki = 47 uM J5K C20 H25 N5 O2 c1ccc(cc1)....
84 3GY5 Kd = 1.8 uM BRN C14 H15 N7 c1cc(ccc1C....
85 1S0R - BEN C7 H8 N2 [H]/N=C(c1....
86 6B6N - BEN C7 H8 N2 [H]/N=C(c1....
87 1C5Q Ki = 0.44 uM ESI C9 H8 I N2 S c1cc2c(cc(....
88 3T25 - BEN C7 H8 N2 [H]/N=C(c1....
89 1GHZ Ki = 16 uM 120 C13 H12 N5 O c1cc2c(cc1....
90 1C5U - ESP C8 H8 N3 S c1cc2cc(sc....
91 1N6X - ABN C7 H9 N c1ccc(cc1)....
92 1O2V Ki = 1.4 uM 847 C18 H13 Br N4 O5 c1cc2c(cc1....
93 1V2Q Ki = 73.62 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
94 6SV8 - BEN C7 H8 N2 [H]/N=C(c1....
95 1TNG Ki = 1.17 mM AMC C7 H16 N C1CCC(CC1)....
96 3T26 - BEN C7 H8 N2 [H]/N=C(c1....
97 6FID - BEN C7 H8 N2 [H]/N=C(c1....
98 5MNO Kd = 143 uM MRZ C6 H13 N3 [H]/N=C(N)....
99 4YTA - BEN C7 H8 N2 [H]/N=C(c1....
100 1GI4 Ki = 0.065 uM 122 C14 H13 N4 O c1ccc(c(c1....
101 1BTY - BEN C7 H8 N2 [H]/N=C(c1....
102 1K1P - MEL C22 H31 N5 O4 c1cc(ccc1C....
103 1V2T Ki = 19.56 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
104 1O3G Ki = 0.011 uM 696 C21 H17 N3 O c1ccc(cc1)....
105 2TIO - BEN C7 H8 N2 [H]/N=C(c1....
106 1C2D Ki = 0.0052 uM BAK C17 H16 N8 O c1cc2c(cc1....
107 1C1R Ki = 0.0235 uM BAI C16 H14 N6 c1ccc2c(c1....
108 1C2H - BAK C17 H16 N8 O c1cc2c(cc1....
109 1O36 Ki = 1.1 uM 607 C24 H19 N5 O5 c1ccc(c(c1....
110 2BY7 - BAM C7 H9 N2 c1ccc(cc1)....
111 3GY8 Kd = 1.8 uM BRN C14 H15 N7 c1cc(ccc1C....
112 5T3H - BEN C7 H8 N2 [H]/N=C(c1....
113 3ITI ic50 = 0.27 uM BRV C8 H4 Br3 N O4 c1(c(c(c(c....
114 2ZFS - 12U C22 H33 N5 O2 [H]/N=C(/c....
115 3GY6 Kd = 1.8 uM BRN C14 H15 N7 c1cc(ccc1C....
116 1O3L - 678 C17 H13 Br N3 O3 c1cc2c(cc1....
117 1BJU Ki = 6.2 uM GP6 C14 H13 Cl N4 O [H]/N=C(c1....
118 1XUJ Ki < 1 nM BOZ C17 H18 N8 O Zn c1cc2c(cc1....
119 1TX7 Ki = 25 uM 4CM C8 H11 N2 O2 P C[P@](=O)(....
120 6B6O - BEN C7 H8 N2 [H]/N=C(c1....
121 3M35 - M35 C25 H20 F4 N4 O3 S CS(=O)(=O)....
122 1MTU - BX3 C27 H30 N4 O3 CC(=N)N1CC....
123 1O32 Ki = 1.8 uM 801 C13 H11 N5 O c1cc(c(nc1....
124 3T27 - BEN C7 H8 N2 [H]/N=C(c1....
125 5LH4 - 6W4 C32 H34 N6 O2 c1ccc(cc1)....
126 1O2Q Ki = 0.021 uM 991 C20 H20 Cl N3 O2 c1cc(c(c(c....
127 1K1J Kd = 28 nM FD2 C27 H30 N4 O5 S [H]/N=C(/c....
128 5MNN - MRZ C6 H13 N3 [H]/N=C(N)....
129 1C1S - BAB C17 H19 N8 c1cc2c(cc1....
130 1QBO Ki = 18 nM 711 C27 H31 N6 O Cc1[nH]c2c....
131 1V2R Ki = 278.96 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
132 1C5R - ESI C9 H8 I N2 S c1cc2c(cc(....
133 6SVV - BEN C7 H8 N2 [H]/N=C(c1....
134 1K1O - IGN C21 H38 N6 O4 C1CCC(CC1)....
135 2ZFT - 10U C20 H29 N5 O2 c1cc(ccc1C....
136 1TIO - BAM C7 H9 N2 c1ccc(cc1)....
137 1V2U Ki = 427 uM BEN C7 H8 N2 [H]/N=C(c1....
138 1MTV - BX3 C27 H30 N4 O3 CC(=N)N1CC....
139 1Y5B Kd = 1.26 uM TL3 C20 H22 N4 O4 c1cc(ccc1C....
140 1G36 Ki = 67 nM R11 C25 H25 N7 [H]/N=C(/c....
141 6SVZ - BEN C7 H8 N2 [H]/N=C(c1....
142 1O2L - 762 C20 H15 Cl N4 O c1ccc(cc1)....
143 1TX8 Ki = 1800 uM AM4 C8 H10 N2 O2 S CS(=O)(=O)....
144 1GI1 Ki = 3.6 uM BMZ C14 H13 N4 O c1ccc(c(c1....
145 1V2W Ki = 97.79 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
146 6SV6 - BEN C7 H8 N2 [H]/N=C(c1....
147 1O3H Ki = 0.05 uM 907 C16 H14 Br N3 O Cc1cc(c(c(....
148 4NCY - BEN C7 H8 N2 [H]/N=C(c1....
149 1O35 - 802 C14 H11 F N4 O c1cc2c(cc1....
150 1PPC Ki = 0.69 uM MID C27 H31 N5 O4 S [H]/N=C(/c....
151 1TNI Ki = 0.1 mM PBN C10 H15 N c1ccc(cc1)....
152 6SVU - BEN C7 H8 N2 [H]/N=C(c1....
153 1V2S Ki = 68 uM BEN C7 H8 N2 [H]/N=C(c1....
154 1LQE Ki = 1507 nM IMA C34 H36 N5 O2 C[N+](C)(C....
155 1O2S Ki = 3.4 uM CR4 C14 H12 N4 O c1ccc(c(c1....
156 1O3M - 785 C15 H11 F3 N4 O2 c1cc2c(cc1....
157 6E5M - CYS THR LYS SER ILE PRO PRO GLN CYS n/a n/a
158 1O2X Ki = 1.4 uM 847 C18 H13 Br N4 O5 c1cc2c(cc1....
159 1O38 Ki = 0.15 uM 653 C22 H22 N5 O c1ccc(cc1)....
160 1G3B Ki = 1.8 uM 108 C11 H15 N3 O3 C[C@@H](C(....
161 1BJV Ki = 13 uM GP8 C20 H18 N4 O2 c1ccc(cc1)....
162 1C1P - BAI C16 H14 N6 c1ccc2c(c1....
163 1C2J - BAK C17 H16 N8 O c1cc2c(cc1....
164 1C2F - BAH C17 H18 N8 O2 c1cc2c(cc1....
165 3LJJ Kd = 300 nM 10U C20 H29 N5 O2 c1cc(ccc1C....
166 1O3I Ki = 0.05 uM 907 C16 H14 Br N3 O Cc1cc(c(c(....
167 1Y3V Ki = 2300 nM UIR C27 H30 N4 O3 c1cc(ccc1[....
168 1UTP Kd = 36 mM PBN C10 H15 N c1ccc(cc1)....
169 2BLV - BEN C7 H8 N2 [H]/N=C(c1....
170 6SVG - BEN C7 H8 N2 [H]/N=C(c1....
171 1TNJ Ki = 11 mM PEA C8 H12 N c1ccc(cc1)....
172 3GY2 Kd = 1.8 uM BRN C14 H15 N7 c1cc(ccc1C....
173 6T0M Ki = 39 uM GOZ C20 H26 N6 O2 c1ccc(cc1)....
174 6B6S - BEN C7 H8 N2 [H]/N=C(c1....
175 1O2P - 972 C18 H19 Cl N4 O2 CC(C)COc1c....
176 1K1I Kd = 264 nM FD1 C26 H28 N4 O5 S [H]/N=C(c1....
177 1GJ6 Ki = 0.23 uM 132 C21 H17 Cl N3 O c1ccc(cc1)....
178 3LJO Kd = 239 nM 11U C21 H31 N5 O2 [H]/N=C(/c....
179 1O2Y Ki = 1.4 uM 847 C18 H13 Br N4 O5 c1cc2c(cc1....
180 6SVN - BEN C7 H8 N2 [H]/N=C(c1....
181 1O31 Ki = 1.8 uM 801 C13 H11 N5 O c1cc(c(nc1....
182 2BY5 - BAM C7 H9 N2 c1ccc(cc1)....
183 1XUI - BAO C17 H14 N8 O c1cc2c(cc1....
184 1C5T Ki = 80 uM ESP C8 H8 N3 S c1cc2cc(sc....
185 1EB2 Ki = 16 nM BPO C28 H28 N4 O3 [H]/N=C(c1....
186 6SVB - BEN C7 H8 N2 [H]/N=C(c1....
187 1O2K Ki = 0.12 uM 656 C18 H20 N4 O2 CC(C)COc1c....
188 5LGO - 6VZ C27 H36 N6 O4 CNC(=O)[C@....
189 1GI0 - BMZ C14 H13 N4 O c1ccc(c(c1....
190 1V2P Ki = 18.45 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
191 1TPS ic50 = 10 nM OSL DLE THR ARG GLU LEU YNM VAL n/a n/a
192 1N6Y - ABN C7 H9 N c1ccc(cc1)....
193 1O34 Ki = 1.8 uM 801 C13 H11 N5 O c1cc(c(nc1....
194 6SUX - BEN C7 H8 N2 [H]/N=C(c1....
195 2ZDL - 45U C20 H28 N4 O3 [H]/N=C(/c....
196 1PPH Ki = 1.2 uM 0ZG C22 H28 N4 O3 S [H]/N=C(/c....
197 2G5N - 23M C16 H15 N3 [H]/N=C(c1....
198 1G3D Ki = 2.8 uM 108 C11 H15 N3 O3 C[C@@H](C(....
199 5MOO Kd = 48.5 mM WOT C6 H8 N c1ccc(cc1)....
200 1O2U Ki = 1.4 uM 847 C18 H13 Br N4 O5 c1cc2c(cc1....
201 1O2R - CR9 C21 H23 F N4 O2 C[C@H]1CCC....
202 3QK1 - BEN C7 H8 N2 [H]/N=C(c1....
203 6SVX - BEN C7 H8 N2 [H]/N=C(c1....
204 5MNH Kd = 20.7 uM BAM C7 H9 N2 c1ccc(cc1)....
205 6B6P - BEN C7 H8 N2 [H]/N=C(c1....
206 3T29 - BEN C7 H8 N2 [H]/N=C(c1....
207 6EAT - CYS THR LYS SER ILE PRO PRO GLN CYS n/a n/a
208 1O2H Ki = 0.068 uM CR3 C20 H21 N3 O2 c1cc(c(c(c....
209 1QB9 Ki = 36 nM 806 C31 H31 N5 O [H]/N=C(/C....
210 2BLW - BEN C7 H8 N2 [H]/N=C(c1....
211 1O3B Ki = 0.074 uM 780 C20 H16 N4 O c1ccc(cc1)....
212 1O2Z Ki = 0.78 uM 312 C25 H20 N4 O6 COc1ccccc1....
213 1K1L Kd = 125 nM FD3 C24 H27 N5 O3 S [H]/N=C(/c....
214 1O2O Ki = 0.44 uM 950 C18 H19 F N4 O2 CC(C)COc1c....
215 1C1Q - BAI C16 H14 N6 c1ccc2c(c1....
216 1F0U Ki = 69 nM RPR C27 H30 N4 O3 C[C@H]([C@....
217 1C2G - BAH C17 H18 N8 O2 c1cc2c(cc1....
218 1O37 Ki = 0.15 uM 653 C22 H22 N5 O c1ccc(cc1)....
219 1O3F Ki = 0.011 uM 696 C21 H17 N3 O c1ccc(cc1)....
220 1JIR - AML C5 H13 N CCCCCN
221 1O2N Ki = 0.81 uM 762 C20 H15 Cl N4 O c1ccc(cc1)....
222 1O3O - 785 C15 H11 F3 N4 O2 c1cc2c(cc1....
223 1CE5 Ki = 18.4 uM BEN C7 H8 N2 [H]/N=C(c1....
224 5MNB Kd = 3.3 mM 2AP C5 H7 N2 c1cc[nH+]c....
225 6DZF - BEN C7 H8 N2 [H]/N=C(c1....
226 5LH8 - 6WH C31 H38 N6 O3 COc1cc(ccc....
227 2ZHD - 12U C22 H33 N5 O2 [H]/N=C(/c....
228 1O2J Ki = 0.12 uM 656 C18 H20 N4 O2 CC(C)COc1c....
229 1AQ7 ic50 = 0.9 uM 34H DIL XPR AG2 n/a n/a
230 1O3K Ki = 0.17 uM 334 C15 H13 Br N4 O Cc1cc(c(c(....
231 2G5V - 22M C16 H15 N3 [H]/N=C(c1....
232 1Y5U Kd = 0.22 uM TL4 C20 H22 N4 O4 c1cc(cc(c1....
233 6SVI - BEN C7 H8 N2 [H]/N=C(c1....
234 1J8A - BEN C7 H8 N2 [H]/N=C(c1....
235 6B6Q - BEN C7 H8 N2 [H]/N=C(c1....
236 1QB1 Ki = 170 nM 974 C28 H27 F2 N6 O5 Cn1ccnc1c2....
237 1O2W Ki = 1.4 uM 847 C18 H13 Br N4 O5 c1cc2c(cc1....
238 1XUF Ki = 0.09 uM BAZ C17 H16 N8 Zn [H]/N=C(c1....
239 1QBN Ki = 1400 nM 688 C22 H17 N5 O5 c1cc(cc(c1....
240 1O33 Ki = 1.8 uM 801 C13 H11 N5 O c1cc(c(nc1....
241 1V2O Ki = 18.45 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
242 1C1N - BAM C7 H9 N2 c1ccc(cc1)....
243 1UTN Kd = 0.321 mM ABN C7 H9 N c1ccc(cc1)....
244 6SVD - BEN C7 H8 N2 [H]/N=C(c1....
245 6T0P Ki = 62 uM M6Q C20 H25 N5 O2 c1ccc(cc1)....
246 6SVW - BEN C7 H8 N2 [H]/N=C(c1....
247 4NA8 Ki = 1.5 nM 1T6 C31 H28 N4 O3 [H]/N=C(/c....
248 5WB6 Ki = 0.02 nM 9ZM C31 H26 Cl F N10 O4 COC(=O)Nc1....
249 5Q0H Ki = 12 nM 9F1 C27 H26 Cl F2 N5 O4 Cc1cc(c(c(....
250 5TKT Ki = 3.2 nM 7DS C28 H26 Cl N9 O4 COC(=O)Nc1....
251 4CRG - J4X C22 H18 N6 O [H]/N=C(c1....
252 5EXL Ki = 3.7 nM 5SS C28 H31 N5 O2 c1ccc(cc1)....
253 6TS5 ic50 = 0.003 uM NW2 C27 H29 N O5 CC(C)c1cc(....
254 6VLU Ki = 149.1 nM R2Y C27 H37 F2 N5 O2 CC(C)C[C@H....
255 5E2O Ki = 2 nM 5JM C26 H21 Cl N6 O4 c1ccc(cc1)....
256 4CRB Ki = 0.027 uM 7P0 C28 H24 Cl N7 O4 c1ccc(cc1)....
257 6TS6 ic50 = 0.004 uM NW5 C27 H26 N2 O4 CC(C)(C#N)....
258 5TKS Ki = 68 nM 7DL C29 H30 Cl2 N8 O3 COC(=O)Nc1....
259 5QTY Ki = 2.5 nM QLJ C32 H33 Cl N8 O5 CCOC(=O)[C....
260 5Q0E Ki = 0.69 nM 9FD C29 H30 Cl N9 O4 C[C@H]1CCC....
261 4CRE - MVN C10 H8 Cl N O CC1=CC(=O)....
262 4CRA Ki = 0.06 uM XJ8 C29 H25 N5 O4 c1ccc(cc1)....
263 1ZHR - BEN C7 H8 N2 [H]/N=C(c1....
264 5E2P Ki = 1.6 nM 7P0 C28 H24 Cl N7 O4 c1ccc(cc1)....
265 3BG8 - BEN C7 H8 N2 [H]/N=C(c1....
266 4X6P Ki = 5 nM 3YU C28 H23 Cl N10 O c1ccc(cc1)....
267 5Q0D Ki = 1 nM 9EY C27 H26 Cl N9 O4 COC(=O)Nc1....
268 4X6O Ki = 1.9 nM 3Y4 C29 H26 Cl2 N8 O3 COC(=O)Nc1....
269 5EXN Ki = 23 nM 5SU C31 H26 Cl N7 O3 COC(=O)Nc1....
270 4CR9 Ki = 80 uM OTW C10 H11 N3 Cc1cc(nc2c....
271 6TS4 ic50 = 2.8 uM J7B C22 H20 N2 O3 c1ccc(c(c1....
272 6USY Ki = 0.0004 uM QGS C28 H28 N2 O4 CC(C)c1cc(....
273 4CRC Ki = 0.0019 uM OTM C26 H21 Cl N10 O2 c1ccc(cc1)....
274 5QCL Ki = 11 nM BUY C27 H21 Cl N6 O4 c1ccc2c(c1....
275 1ZHM - BEN C7 H8 N2 [H]/N=C(c1....
276 5EXM Ki = 6.3 nM 5ST C29 H34 N4 O3 COC(=O)Nc1....
277 4TY7 Ki = 0.3 nM 39F C26 H30 Cl N7 O c1ccc(cc1)....
278 5QTT Ki = 3.4 nM QEY C30 H29 Cl F N7 O4 C[C@@H]1CC....
279 6W50 Ki = 0.3 nM SWP C31 H29 Cl F2 N4 O4 C[C@@H]1CC....
280 5QQP Ki = 5.3 nM NR7 C29 H30 Cl N5 O4 COC(=O)Nc1....
281 6C0S Ki = 89 nM EEJ C31 H31 Cl2 N9 O4 CC(=O)N1CC....
282 4CRF Ki = 0.0005 uM R9B C29 H23 Cl N4 O5 c1ccc(cc1)....
283 5QCN Ki = 6 nM BVM C36 H34 Cl N7 O7 CCOC(=O)[C....
284 6VLV Ki = 5.33 nM R3A C19 H25 Cl N6 O4 S [H]/N=C(/N....
285 5QTV Ki = 1.1 nM QLS C28 H27 Cl F3 N9 O3 COC(=O)Nc1....
286 4X6M Ki = 5.8 nM 3Y3 C27 H26 Cl2 N8 O c1ccc(cc1)....
287 5QTW Ki = 0.46 nM QLM C29 H30 Cl N9 O5 COC(=O)[C@....
288 4CR5 Ki = 70 uM 0TU C9 H6 Cl N O c1cc2c(cc1....
289 4CRD Ki = 0.08 uM OTJ C22 H22 Cl2 N8 O3 COC(=O)Nc1....
290 5QCM Ki = 110 nM BVJ C28 H23 Cl F N7 O4 COC(=O)Nc1....
291 5NB6 ic50 = 0.5 uM 8S2 C22 H21 F3 N6 O4 c1ccc2c(c1....
292 6FTY - E7H C20 H24 N4 O2 c1cc2c(cc(....
293 6QMR ic50 = 0.012 uM J6T C23 H23 N O4 c1ccc(c(c1....
294 5NAW ic50 = 0.05 uM 8RZ C23 H20 F3 N5 O4 c1ccc2c(c1....
295 5MT0 Kd ~ 500 uM QJS C19 H15 F N2 O3 c1ccc(cc1)....
296 6FUG Kd = 50 uM E85 C18 H17 N7 O c1cc(cc(c1....
297 5NAR ic50 = 0.5 uM 8RW C22 H20 F3 N5 O4 c1ccc2c(c1....
298 5FBE ic50 = 14 uM 5W5 C22 H22 F3 N3 O5 COC(=O)c1c....
299 6FUH Kd = 170 uM E88 C20 H23 N5 O2 CC(C)[C@@H....
300 5FBI Kd = 1600 uM 5WD C17 H14 N2 O4 c1cc(cc(c1....
301 6QMT ic50 = 0.12 uM J7B C22 H20 N2 O3 c1ccc(c(c1....
302 6FUT Kd = 20 uM E82 C24 H24 N2 O c1ccc2c(c1....
303 6FUJ ic50 = 120 uM E8B C18 H22 N2 O CC(C)CC(=O....
304 5FCK Kd = 0.006 uM 5WC C23 H22 Cl F N6 O3 C[C@H](c1c....
305 5NB7 ic50 = 0.006 uM 8NQ C21 H19 Br N6 O3 c1ccc2c(c1....
306 5MT4 Kd ~ 500 uM M7O C15 H14 N2 O3 c1ccc(cc1)....
307 5NBA ic50 = 0.05 uM 8S5 C22 H19 F4 N5 O4 c1ccc2c(c1....
308 6FUI Kd = 35 uM E7W C22 H25 N5 O2 c1ccc2c(c1....
309 6FTZ Kd = 1000 uM E7E C17 H16 N4 O2 c1cc(cc(c1....
310 6A8N Ki = 6.8 nM CYS PRO ALA TYR SER ARG TYR ILE GLY CYS n/a n/a
311 1ELC - 0Z3 C26 H34 F3 N4 O3 CC(C)c1ccc....
312 1ELD Ki = 0.2 uM 0Z0 C21 H19 F6 N3 O3 NULL
313 7EST - 0Z2 C18 H21 F6 N3 O3 CC(C)C[C@@....
314 2BD4 - LYS TYR PRO PHE VAL GLU PRO ILE n/a n/a
315 1ELB Ki = 70 nM 0Z4 C23 H36 F3 N4 O3 CC(C)C[C@@....
316 6TH7 ic50 = 1.18 nM O4Q 5XU ABA ILE ABA VAL N9K PHA AA4 n/a n/a
317 1ELE Ki = 0.14 uM 0QN C17 H19 F6 N3 O3 NULL
318 4GVU ic50 = 30 nM 6NA GLN THR DBU GLJ PHE YNM VAL n/a n/a
319 1NES - ACE ALA PRO ALA n/a n/a
320 2BDB - ALA ALA n/a n/a
321 1BMA Ki = 26 uM 0QH C27 H36 F3 N4 O3 NULL
322 2EST - 2Z5 C18 H23 F6 N4 O3 NULL
323 1ELA Ki = 0.44 uM 0Z1 C22 H32 F3 N4 O3 CC(C)c1ccc....
324 1QR3 ic50 = 0.26 uM ALQ CIR THR DBU GLJ PHE TYJ VAL n/a n/a
325 1BIT - BEN C7 H8 N2 [H]/N=C(c1....
326 1HJ8 - BAM C7 H9 N2 c1ccc(cc1)....
327 1UTL Ka = 293 M^-1 PRA C9 H13 N c1ccc(cc1)....
328 2TBS - BEN C7 H8 N2 [H]/N=C(c1....
329 2ZPQ - BEN C7 H8 N2 [H]/N=C(c1....
330 1UTJ Kd = 0.144 mM ABN C7 H9 N c1ccc(cc1)....
331 1UTM Ka = 243 M^-1 PEA C8 H12 N c1ccc(cc1)....
332 1MBQ - BEN C7 H8 N2 [H]/N=C(c1....
333 2ZPS - BEN C7 H8 N2 [H]/N=C(c1....
334 2ZPR - BEN C7 H8 N2 [H]/N=C(c1....
335 1L2E - BEN C7 H8 N2 [H]/N=C(c1....
336 3VFE - 0HL C26 H26 N4 O4 S3 [H]/N=C(c1....
337 6QH9 - J3B C13 H16 N4 O2 [H]/N=C(/c....
338 6QFH ic50 = 1.38 uM J08 C23 H22 N6 O [H]/N=C(/c....
339 6QHB - J2W C15 H15 N3 O3 [H]/N=C(/c....
340 6SKC - BEN C7 H8 N2 [H]/N=C(c1....
341 1LO6 - BEN C7 H8 N2 [H]/N=C(c1....
342 6QFF ic50 = 2.04 uM J08 C23 H22 N6 O [H]/N=C(/c....
343 6QHC - 135 C14 H13 N3 O2 [H]/N=C(c1....
344 4D8N ic50 = 1.8 uM 0HM C24 H24 N5 O2 c1ccc(cc1)....
345 6QFG ic50 = 3.01 uM J08 C23 H22 N6 O [H]/N=C(/c....
346 6QHA - J2Q C16 H17 N3 O3 [H]/N=C(/c....
347 3P8G - BEN C7 H8 N2 [H]/N=C(c1....
348 1EAX - BEN C7 H8 N2 [H]/N=C(c1....
349 2GV6 Ki = 0.046 uM 730 C28 H35 N7 O3 S [H]/N=C(c1....
350 4R0I Ki = 0.3 uM 3KM C27 H33 N5 O4 S [H]/N=C(c1....
351 4O97 Ki = 3 nM NTX C29 H34 N6 O3 [H]/N=C(N)....
352 2GV7 Ki = 0.014 uM 672 C36 H54 N8 O4 S [H]/N=C(c1....
353 4O9V Ki = 10 nM NT4 C27 H30 N6 O3 [H]/N=C(N)....
354 1IAU Ki = 80 nM ACE ILE GLU PRO ASJ n/a n/a
355 1ANE - BEN C7 H8 N2 [H]/N=C(c1....
356 1J16 Ki = 143 uM BEN C7 H8 N2 [H]/N=C(c1....
357 1J14 Ki = 32.2 uM BEN C7 H8 N2 [H]/N=C(c1....
358 1BRA Ki = 15000 uM BEN C7 H8 N2 [H]/N=C(c1....
359 1J15 Ki = 143 uM BEN C7 H8 N2 [H]/N=C(c1....
360 1TRM - BEN C7 H8 N2 [H]/N=C(c1....
361 1J17 Ki = 6.05 uM ZEN C25 H27 Cl N4 O3 S c1cc(cc2c1....
362 1ANC - BEN C7 H8 N2 [H]/N=C(c1....
363 1QL9 Ki = 4.45 uM ZEN C25 H27 Cl N4 O3 S c1cc(cc2c1....
364 1DPO - BEN C7 H8 N2 [H]/N=C(c1....
365 1AND - BEN C7 H8 N2 [H]/N=C(c1....
366 1W0Z Ki = 21 nM SI1 C18 H29 N5 O5 S [H]/N=C(c1....
367 4ZHL Kd = 0.0147 uM CYS PRO ALA TYR SER ARG TYR ILE GLY CYS n/a n/a
368 2VIV ic50 = 520 nM VG2 C22 H28 Cl N3 O2 Cc1cc(cc(c....
369 1SC8 Ki = 0.036 uM 2IN C20 H25 N5 O5 S c1ccc(cc1)....
370 1OWE Ki = 0.631 uM 675 C18 H15 N3 O [H]/N=C(/c....
371 4X1Q - CYS PRO ALA TYR SER ARG TYR LEU ASP CYS n/a n/a
372 2VIP ic50 = 5.2 uM L1R C18 H20 Cl2 N2 O3 CC(C)Oc1cc....
373 5ZAF Ki = 166 nM 28I C16 H21 N7 O2 [H]/N=C(N)....
374 1SQT Ki = 0.63 uM UI3 C16 H16 N4 O3 S [H]/N=C(/c....
375 1W13 Ki = 2 nM SM1 C21 H28 N6 O5 S [H]/N=C(/N....
376 1OWH Ki = 40 nM 239 C19 H18 N4 O [H]/N=C(/c....
377 1EJN Ki = 2.4 uM AGB C19 H27 N5 O [H]/N=C(/N....
378 4ZHM Kd = 0.00081 uM MRZ CYS PRO ALA TYR SER ALA TYR ILE GLY CYS n/a n/a
379 2VIN ic50 > 1 mM 505 C11 H17 N O Cc1cccc(c1....
380 5ZA8 Ki = 508 nM 27I C16 H23 N9 O [H]/N=C(/N....
381 5ZA7 Ki = 1356 nM HMX C12 H18 Cl N7 O C1CCCN(CC1....
382 4X0W - MRZ CYS PRO ALA TYR SER DAL TYR LEU ASP CYS n/a n/a
383 1U6Q - 745 C20 H18 N2 [H]/N=C(/c....
384 5ZA9 Ki = 183 nM 50I C20 H23 N7 O2 [H]/N=C(/N....
385 2VIQ ic50 = 1.3 uM D55 C21 H28 N2 O4 CCOc1ccc(c....
386 4X1P - CYS PRO ALA TYR SER DAL TYR LEU ASP CYS MRZ n/a n/a
387 6NMB Ki = 2.01 mM AMH C8 H15 N O2 C1CC(CCC1C....
388 5ZAG Ki = 108 nM 94I C16 H21 N9 O [H]/N=C(N)....
389 5ZC5 Ki = 88 nM 09I C20 H22 F N7 O2 [H]/N=C(/N....
390 1VJ9 Ki = 0.028 uM 5IN C28 H33 N5 O6 S c1ccc(cc1)....
391 1F5K Ki = 180 uM BAM C7 H9 N2 c1ccc(cc1)....
392 5ZAE Ki = 156 nM EAU C16 H21 N7 O2 [H]/N=C(/N....
393 1OWD Ki = 6.3 nM 497 C23 H24 N4 O CC[C@H]1CN....
394 2VNT Ki = 9.9 nM QGG C15 H16 Cl N5 O4 S c1cc2c(cc1....
395 2VIO ic50 = 40 uM L1O C9 H9 Cl2 N O3 c1c(cc(c(c....
396 1F5L Ki = 5.3 uM AMR C6 H8 Cl N7 O c1(c(nc(c(....
397 5ZAJ Ki = 42 nM 32I C18 H25 N9 O3 [H]/N=C(/N....
398 2R2W Ki = 34 uM 4PG C15 H15 N3 O [H]/N=C(/N....
399 2VIW ic50 = 72 nM D56 C24 H32 Cl N3 O3 CCOc1c(cc(....
400 1W11 Ki = 6 nM SK1 C21 H27 N5 O5 S [H]/N=C(c1....
401 1SQA Ki = 0.00062 uM UI1 C23 H21 N7 O c1cnc(nc1)....
402 1VJA Ki = 0.02 uM 7IN C21 H27 N5 O6 S c1ccc(cc1)....
403 1SQO Ki = 0.035 uM UI2 C15 H13 N5 c1cc2ccc(c....
404 1GDN - GLY ALA LYS n/a n/a
405 1FY5 - GLY ALA LYS n/a n/a
406 1FY4 - GLY ALA ARG n/a n/a
407 1PQ8 - GLY GLY ARG n/a n/a
408 1FN8 - GLY ALA ARG n/a n/a
409 1PQ7 - ARG C6 H15 N4 O2 C(C[C@@H](....
410 1PQ5 - ARG C6 H15 N4 O2 C(C[C@@H](....
411 1H4W Ki = 22 uM BEN C7 H8 N2 [H]/N=C(c1....
412 5TP0 Ki = 3.66 uM BRN C14 H15 N7 c1cc(ccc1C....
413 1T32 Ki = 38 nM OHH C40 H35 N2 O6 P CN(C1CCN(C....
414 4K60 ic50 = 570 uM 1P8 C8 H6 Br N O c1cc2c(cc1....
415 1T31 Ki = 2.3 nM OHH C40 H35 N2 O6 P CN(C1CCN(C....
416 4K5Z - 1P7 C8 H6 Cl N O c1cc2c(cc1....
417 3N7O Ki = 72 nM N7O C19 H15 Cl F2 N O3 P S C[P@@](=O)....
418 3S0N ic50 = 180 nM 0BB C21 H20 N2 O3 S Cc1cccc2c1....
419 5YJM Kd = 0.000000064 M 8W3 C30 H32 Cl N5 O6 CC[C@H](c1....
420 4K2Y ic50 = 470 uM ES2 C8 H6 Cl N O c1cc2c(cc1....
421 5YJP ic50 = 0.24 uM 8W6 C26 H31 Cl N4 O6 CC[C@H](c1....
422 4K69 ic50 = 0.04 uM 1P9 C22 H22 Br N3 O4 CCC[C@@H](....
423 1OSS Ki = 16.4 uM BEN C7 H8 N2 [H]/N=C(c1....
424 3BEU - BEN C7 H8 N2 [H]/N=C(c1....
425 5XWL - ACE THR ARG GLU n/a n/a
426 5XWJ - ACE THR ARG GLU n/a n/a
427 1V6D - PRO ASP AIB LEU AIB LEU ALA TBF NME n/a n/a
428 1YF4 Ki = 5 nM CYS TYR PHE GLN ASN CYS PRO ARG GLY NH2 n/a n/a
429 1S6H - 4BZ C8 H10 N2 O [H]/N=C(c1....
430 1S83 - 4HA C4 H12 N O C(CCO)C[NH....
431 1S5S - PG3 C4 H12 N3 O C(CNC(=[NH....
432 5A09 ic50 = 3.5 nM JJD C23 H18 F3 N3 O4 CC1=C([C@H....
433 5A8X ic50 = 6.5 nM IUY C24 H20 F3 N4 O2 CCOC(=O)C1....
434 5ABW ic50 = 17 nM WQQ C26 H24 Cl N3 O5 S Cc1c(c(on1....
435 5A8Y ic50 = 0.17 nM VBM C23 H16 F3 N7 O2 CC1=C([C@H....
436 5A0B ic50 = 5 nM JJX C29 H29 F3 N6 O2 CC1=C([C@H....
437 5A8Z ic50 = 28 nM IUL C21 H16 F3 N5 O2 CN1CC2=C([....
438 3Q77 ic50 = 6 nM 2HY C22 H18 F3 N3 O4 CC1=C([C@H....
439 5A0C ic50 = 0.54 nM JJV C21 H15 F3 N4 O3 S CC1=C([C@H....
440 5A0A Ki = 15 nM JJS C20 H15 F3 N4 O2 CC1=C([C@H....
441 2AIQ - BEN C7 H8 N2 [H]/N=C(c1....
442 2OQ5 - BEN C7 H8 N2 [H]/N=C(c1....
443 5F03 - 5TA C24 H20 Cl N3 O3 c1cc(cc(c1....
444 2ZA5 Ki = 3.7 nM 2FF C26 H24 N2 O3 c1ccc(cc1)....
445 2FPZ Ki = 110 uM 270 C7 H7 N3 C1=CC2=NC(....
446 2BM2 Ki = 15 nM PM2 C26 H29 N3 O c1ccc(cc1)....
447 3V7T Ki = 62 nM 0GX C23 H28 Br F N2 O2 S CCCOc1c(c(....
448 2ZEB - 11M C23 H24 N2 O2 S2 CSc1c2cccc....
449 4A6L Ki = 10 nM P43 C25 H23 F N2 O2 c1ccc(c(c1....
450 2ZEC - 11N C22 H24 N2 O2 c1ccc(cc1)....
451 4NFE - BEN C7 H8 N2 [H]/N=C(c1....
452 2ANW - BAM C7 H9 N2 c1ccc(cc1)....
453 2ANY - BAM C7 H9 N2 c1ccc(cc1)....
454 5TJX - GBT C29 H33 N7 O3 Cc1c2c(cc(....
455 6O1S - 7SD C23 H25 N7 O Cc1cc(nc(c....
456 6T7P Ki = 0.97 uM MU8 C26 H24 Cl N3 O3 c1ccc(cc1)....
457 6QFE ic50 = 0.08 uM J08 C23 H22 N6 O [H]/N=C(/c....
458 6B74 - BEN C7 H8 N2 [H]/N=C(c1....
459 1A0J - BEN C7 H8 N2 [H]/N=C(c1....
460 2ZGJ - SER SER GLY LYS VAL PRO LEU SER n/a n/a
461 2ZGH - SER SER GLY LYS VAL PRO LEU n/a n/a
462 2BDG - PBZ C7 H10 N3 c1cc(ccc1C....
463 5Y9L ic50 = 1.9 uM 8R3 C24 H28 Cl N5 O5 CN(C)/N=C1....
464 5YJK ic50 = 0.82 uM 8VX C24 H30 Cl N5 O5 S CN(C)/N=C1....
465 5FAH ic50 = 0.7 uM 5VT C26 H29 N3 O3 COc1ccc(cc....
466 3TJV - PRO THR SER TYR ALA GLY ASP ASP SER GLY n/a n/a
467 6AHS ic50 = 1.5 uM 9YO C19 H18 Cl N3 O2 S Cc1ccc2c(c....
468 5ZFI ic50 = 1.2 uM 9C9 C26 H29 Cl2 N7 O2 Cn1cc(cn1)....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: ES2; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 ES2 1 1
2 1P8 0.511111 0.935484
Similar Ligands (3D)
Ligand no: 1; Ligand: ES2; Similar ligands found: 1311
No: Ligand Similarity coefficient
1 CLW 1.0000
2 36R 1.0000
3 VGD 1.0000
4 5VM 0.9976
5 ET2 0.9953
6 JA8 0.9947
7 K2T 0.9885
8 H42 0.9863
9 FBB 0.9860
10 4FS 0.9767
11 CWJ 0.9758
12 JB5 0.9758
13 2AQ 0.9756
14 11S 0.9750
15 03V 0.9747
16 5MI 0.9744
17 H4N 0.9743
18 ES5 0.9741
19 F60 0.9733
20 FK1 0.9730
21 2K4 0.9724
22 94W 0.9722
23 COU 0.9721
24 OCH 0.9719
25 KJU 0.9719
26 ES9 0.9718
27 XAZ 0.9716
28 5H1 0.9715
29 8NY 0.9714
30 14O 0.9713
31 5MB 0.9700
32 6AI 0.9697
33 6RQ 0.9695
34 BZX 0.9684
35 5GU 0.9681
36 5XC 0.9677
37 SYV 0.9676
38 2HQ 0.9672
39 AX7 0.9671
40 5JQ 0.9668
41 URC 0.9660
42 BZ3 0.9647
43 ABV 0.9645
44 XQ0 0.9643
45 IV2 0.9639
46 5OB 0.9637
47 J6W 0.9633
48 270 0.9631
49 75K 0.9630
50 MQN 0.9630
51 F9Y 0.9628
52 4JQ 0.9628
53 2MI 0.9626
54 5JL 0.9624
55 5WV 0.9617
56 PHB 0.9612
57 3PF 0.9608
58 9R5 0.9602
59 8ZE 0.9601
60 B55 0.9593
61 HDH 0.9589
62 P92 0.9589
63 G3E 0.9587
64 4JT 0.9585
65 4YO 0.9582
66 N2I 0.9581
67 5QY 0.9581
68 0TU 0.9579
69 7MU 0.9572
70 DMD 0.9563
71 86J 0.9560
72 8TX 0.9559
73 BTY 0.9555
74 MR1 0.9555
75 RM1 0.9555
76 D48 0.9548
77 2BG 0.9548
78 KDV 0.9545
79 3ID 0.9543
80 XIY 0.9529
81 PAB 0.9528
82 ODO 0.9527
83 4HM 0.9523
84 4FA 0.9523
85 I3A 0.9518
86 E5X 0.9516
87 XM0 0.9511
88 NPO 0.9510
89 J5I 0.9504
90 8WO 0.9503
91 OTR 0.9502
92 HBD 0.9497
93 ISZ 0.9493
94 TTL 0.9493
95 M6N 0.9488
96 SE2 0.9485
97 1Y6 0.9485
98 JAE 0.9483
99 PNZ 0.9483
100 BCU 0.9480
101 DOB 0.9480
102 BHA 0.9478
103 GLC 0.9478
104 1P7 0.9477
105 J9Q 0.9477
106 MEW 0.9474
107 ISN 0.9473
108 1M2 0.9472
109 7W4 0.9472
110 DHR 0.9471
111 FA0 0.9469
112 ANN 0.9467
113 E7S 0.9466
114 BGC 0.9466
115 CTL 0.9462
116 4M0 0.9461
117 A29 0.9459
118 KKN 0.9459
119 TH7 0.9457
120 6NT 0.9450
121 5NU 0.9448
122 QWN 0.9446
123 7HQ 0.9446
124 HMH 0.9445
125 7W1 0.9445
126 PKU 0.9443
127 HIS 0.9441
128 0HO 0.9439
129 5B1 0.9437
130 67N 0.9434
131 174 0.9434
132 AEF 0.9434
133 ES7 0.9433
134 8IG 0.9432
135 5CU 0.9431
136 M5K 0.9431
137 SKA 0.9430
138 4XR 0.9430
139 HBA 0.9429
140 MS9 0.9428
141 TGX 0.9427
142 Z82 0.9426
143 0JD 0.9426
144 2A9 0.9425
145 BHO 0.9424
146 1PT 0.9424
147 4MA 0.9423
148 1DW 0.9422
149 826 0.9421
150 HQJ 0.9420
151 PBZ 0.9417
152 WCE 0.9417
153 4CS 0.9416
154 AHR 0.9416
155 AJ2 0.9411
156 QUZ 0.9409
157 0HN 0.9409
158 069 0.9408
159 OVM 0.9407
160 AC6 0.9405
161 AZ8 0.9403
162 GAB 0.9403
163 QXW 0.9402
164 9DG 0.9402
165 P72 0.9399
166 INO 0.9399
167 6M9 0.9398
168 DHB 0.9398
169 HQT 0.9398
170 3MB 0.9397
171 173 0.9397
172 1F1 0.9397
173 717 0.9397
174 I1E 0.9396
175 Q88 0.9395
176 5NI 0.9394
177 97T 0.9394
178 4AA 0.9393
179 ES0 0.9392
180 A7W 0.9391
181 4HC 0.9391
182 XYL 0.9390
183 RB5 0.9390
184 R8S 0.9389
185 NPY 0.9389
186 2FY 0.9388
187 CWM 0.9388
188 KOJ 0.9388
189 ASO 0.9387
190 2HU 0.9384
191 3HM 0.9384
192 NIZ 0.9381
193 8H8 0.9381
194 9FL 0.9379
195 4NC 0.9378
196 YH7 0.9378
197 3NT 0.9378
198 Q24 0.9377
199 12Q 0.9377
200 EA1 0.9375
201 3HA 0.9375
202 4BZ 0.9375
203 3DM 0.9373
204 KUF 0.9373
205 4A3 0.9371
206 B62 0.9370
207 4P5 0.9369
208 TYL 0.9368
209 AQO 0.9368
210 CFI 0.9367
211 2ZM 0.9366
212 5QX 0.9365
213 LCN 0.9364
214 YRL 0.9363
215 6NI 0.9362
216 M1A 0.9362
217 GUN 0.9361
218 BOA 0.9360
219 F4E 0.9359
220 93K 0.9359
221 XAN 0.9356
222 4VP 0.9355
223 2F6 0.9355
224 6ME 0.9353
225 DIN 0.9351
226 FHB 0.9350
227 1XM 0.9349
228 3NY 0.9348
229 OVV 0.9348
230 FYU 0.9347
231 CWS 0.9346
232 3HB 0.9345
233 NNO 0.9343
234 XX2 0.9340
235 3AB 0.9340
236 3F0 0.9334
237 6KT 0.9333
238 MSR 0.9333
239 KJH 0.9332
240 AZA 0.9332
241 8GC 0.9332
242 NMJ 0.9332
243 OW4 0.9331
244 92K 0.9331
245 0CU 0.9330
246 3A9 0.9329
247 NOJ 0.9329
248 EUG 0.9329
249 PZM 0.9328
250 A7H 0.9327
251 BPN 0.9326
252 MRW 0.9325
253 JFJ 0.9324
254 0RW 0.9324
255 ZZT 0.9323
256 AMH 0.9321
257 2HO 0.9321
258 HC4 0.9320
259 2CK 0.9319
260 4BL 0.9319
261 NDH 0.9317
262 JAW 0.9315
263 A2F 0.9315
264 0FO 0.9315
265 15E 0.9314
266 F9P 0.9313
267 BCP 0.9313
268 IGA 0.9313
269 4NM 0.9312
270 MYJ 0.9311
271 XYP 0.9311
272 PE0 0.9310
273 44V 0.9310
274 BRT 0.9310
275 SW7 0.9307
276 4WL 0.9306
277 2D0 0.9305
278 IWT 0.9305
279 4TU 0.9305
280 HMU 0.9305
281 L5V 0.9304
282 PXL 0.9304
283 4MU 0.9303
284 XRG 0.9303
285 4BY 0.9303
286 9CA 0.9302
287 2EC 0.9302
288 ABI 0.9301
289 3OC 0.9300
290 BSX 0.9298
291 259 0.9298
292 OTW 0.9298
293 UNJ 0.9298
294 FBM 0.9297
295 NOY 0.9297
296 MUA 0.9297
297 XHP 0.9296
298 P9P 0.9296
299 3M0 0.9294
300 F05 0.9294
301 TSS 0.9294
302 42A 0.9292
303 0P6 0.9292
304 DQU 0.9290
305 5HN 0.9290
306 HX3 0.9289
307 LZM 0.9288
308 BZ2 0.9285
309 428 0.9285
310 IFL 0.9284
311 YPN 0.9283
312 NSP 0.9283
313 3ZB 0.9282
314 SHA 0.9281
315 GTQ 0.9279
316 6VD 0.9279
317 DX4 0.9278
318 R9Y 0.9278
319 AZ9 0.9277
320 1IT 0.9276
321 9EW 0.9276
322 GOJ 0.9273
323 PHU 0.9271
324 LT2 0.9271
325 TPA 0.9270
326 6AP 0.9269
327 CPZ 0.9269
328 4JM 0.9268
329 BEZ 0.9267
330 141 0.9265
331 6TZ 0.9265
332 NFM 0.9262
333 DBH 0.9261
334 TT4 0.9260
335 8CM 0.9259
336 2AK 0.9258
337 DEN 0.9258
338 FUD 0.9258
339 5RG 0.9254
340 OAA 0.9253
341 JBK 0.9252
342 6M4 0.9252
343 BEN 0.9251
344 5RN 0.9250
345 BAM 0.9250
346 PEA 0.9250
347 KTA 0.9248
348 3BZ 0.9248
349 AZG 0.9248
350 PQ0 0.9247
351 H8N 0.9246
352 G2F 0.9245
353 F81 0.9245
354 4ZA 0.9245
355 6PC 0.9243
356 44W 0.9242
357 9TW 0.9241
358 53C 0.9241
359 NCA 0.9240
360 XBT 0.9240
361 FQI 0.9238
362 FE DB1 0.9238
363 ICB 0.9238
364 B57 0.9235
365 15N 0.9235
366 GAL 0.9233
367 HHI 0.9233
368 FDB 0.9233
369 G3F 0.9233
370 3Z8 0.9232
371 DE5 0.9232
372 K34 0.9232
373 PIM 0.9232
374 54G 0.9230
375 JDN 0.9230
376 JB8 0.9230
377 QBK 0.9229
378 HHA 0.9228
379 RNS 0.9228
380 IND 0.9228
381 24B 0.9228
382 GCS 0.9228
383 MLT 0.9227
384 463 0.9226
385 BZI 0.9226
386 82I 0.9226
387 F31 0.9225
388 K97 0.9225
389 5M0 0.9223
390 23A 0.9223
391 LXC 0.9223
392 CHB 0.9222
393 M4T 0.9222
394 14J 0.9222
395 SNU 0.9222
396 LZ1 0.9220
397 MO8 0.9219
398 HH5 0.9218
399 I3E 0.9217
400 GVG 0.9214
401 SX1 0.9213
402 OVP 0.9213
403 DGJ 0.9211
404 4JP 0.9211
405 24W 0.9210
406 J9T 0.9210
407 BZF 0.9210
408 3BU 0.9209
409 SWA 0.9209
410 LNR 0.9208
411 IFM 0.9207
412 5SG 0.9206
413 MVN 0.9206
414 XUL 0.9205
415 1SQ 0.9205
416 DRL 0.9205
417 BEA 0.9204
418 SOE 0.9204
419 R20 0.9202
420 52C 0.9202
421 LPK 0.9201
422 NAG 0.9201
423 CH9 0.9201
424 E1T 0.9200
425 5RO 0.9198
426 JLZ 0.9198
427 7ME 0.9196
428 PRF 0.9196
429 3QV 0.9195
430 2AL 0.9193
431 6CS 0.9193
432 N5J 0.9191
433 IF7 0.9190
434 290 0.9190
435 ICO 0.9189
436 PIY 0.9189
437 TZF 0.9189
438 5IQ 0.9188
439 TIU 0.9188
440 5MK 0.9187
441 SAL 0.9187
442 GZL 0.9186
443 LDP 0.9186
444 QSB 0.9185
445 HQD 0.9184
446 1NP 0.9183
447 IHB 0.9183
448 5Q0 0.9181
449 FAN 0.9180
450 PZI 0.9179
451 ESP 0.9179
452 MXN 0.9178
453 OK7 0.9177
454 HQY 0.9176
455 4YS 0.9176
456 0R1 0.9175
457 BE2 0.9175
458 1LQ 0.9174
459 YCP 0.9174
460 CFP 0.9172
461 NIO 0.9172
462 0CT 0.9172
463 5LA 0.9170
464 MPI 0.9170
465 7VS 0.9169
466 SVN 0.9168
467 SRT 0.9167
468 PH2 0.9167
469 1MC 0.9167
470 5UC 0.9166
471 8W9 0.9165
472 N8Y 0.9165
473 E7Z 0.9165
474 NBZ 0.9165
475 SNO 0.9165
476 RSO 0.9164
477 TH0 0.9163
478 42J 0.9161
479 0N7 0.9159
480 GVH 0.9159
481 M3H 0.9157
482 PBA 0.9156
483 DIE 0.9156
484 4JL 0.9153
485 BDP 0.9153
486 KT7 0.9152
487 3DO 0.9152
488 7B4 0.9151
489 FDR 0.9150
490 4ME 0.9150
491 ES1 0.9149
492 12T 0.9148
493 QWW 0.9146
494 5WZ 0.9145
495 4Z4 0.9145
496 II6 0.9145
497 AC0 0.9145
498 PAC 0.9144
499 VNL 0.9144
500 CN0 0.9143
501 NTN 0.9141
502 SAN 0.9141
503 8NX 0.9140
504 SN4 0.9139
505 4NB 0.9137
506 B53 0.9136
507 JPZ 0.9134
508 C1M 0.9133
509 L99 0.9133
510 UNU 0.9133
511 IDM 0.9132
512 6FZ 0.9131
513 RNO 0.9130
514 9TZ 0.9130
515 HHH 0.9128
516 M1Q 0.9128
517 RBL 0.9127
518 QX2 0.9127
519 XQG 0.9127
520 ZBT 0.9127
521 6GU 0.9127
522 IFP 0.9127
523 0F9 0.9127
524 M0Q 0.9123
525 TSU 0.9123
526 ESX 0.9122
527 8OZ 0.9121
528 3XX 0.9121
529 C2B 0.9121
530 IPB 0.9120
531 92P 0.9119
532 4SV 0.9118
533 8S0 0.9117
534 CLZ 0.9116
535 261 0.9115
536 HSO 0.9114
537 MCT 0.9113
538 1AL 0.9112
539 5MH 0.9111
540 C2Y 0.9109
541 PZA 0.9109
542 RD4 0.9108
543 TDR 0.9107
544 SLS 0.9105
545 FP1 0.9104
546 AEG 0.9104
547 JZ9 0.9102
548 8WT 0.9102
549 SRO 0.9102
550 M4E 0.9101
551 1KP 0.9100
552 VK3 0.9100
553 0W8 0.9100
554 45L 0.9099
555 FBA 0.9099
556 GXY 0.9099
557 9ZE 0.9097
558 A7N 0.9096
559 SJ5 0.9096
560 AKG 0.9096
561 PBC 0.9095
562 4HO 0.9095
563 OXZ 0.9094
564 4VY 0.9091
565 AL0 0.9089
566 VGL 0.9089
567 AX3 0.9089
568 NQ 0.9087
569 HIO 0.9086
570 EN1 0.9086
571 N3W 0.9085
572 ASC 0.9085
573 FCR 0.9085
574 URF 0.9085
575 GDE 0.9085
576 GF4 0.9084
577 7VP 0.9081
578 ADE 0.9079
579 M2K 0.9078
580 AJV 0.9075
581 XLS 0.9074
582 3U4 0.9074
583 KJY 0.9073
584 X0V 0.9073
585 HHR 0.9072
586 RSF 0.9072
587 QMP 0.9071
588 SS1 0.9069
589 BE7 0.9068
590 PDC 0.9068
591 0FN 0.9068
592 DBX 0.9068
593 CXF 0.9067
594 G4D 0.9066
595 PHE 0.9066
596 ICP 0.9066
597 XBZ 0.9066
598 HH8 0.9065
599 NCT 0.9065
600 HPA 0.9064
601 4ZC 0.9063
602 DHI 0.9061
603 AMC 0.9061
604 4XH 0.9060
605 258 0.9058
606 PEY 0.9058
607 HLR 0.9058
608 39O 0.9057
609 4JC 0.9057
610 PJW 0.9055
611 W81 0.9054
612 DYA 0.9054
613 R8V 0.9054
614 LYL 0.9053
615 HLZ 0.9053
616 DFB 0.9052
617 ES6 0.9051
618 ADZ 0.9049
619 GLO 0.9048
620 JG8 0.9048
621 L14 0.9047
622 3R6 0.9047
623 DBJ 0.9046
624 2FQ 0.9046
625 LQ2 0.9046
626 WBU 0.9046
627 43M 0.9045
628 2LY 0.9044
629 AN3 0.9044
630 RHU 0.9043
631 RXA 0.9041
632 SKM 0.9040
633 36Y 0.9038
634 G5V 0.9037
635 51R 0.9037
636 9MG 0.9037
637 FA1 0.9035
638 GCU 0.9035
639 MPV 0.9034
640 QX4 0.9034
641 IAC 0.9033
642 S2G 0.9032
643 INE 0.9032
644 X05 0.9031
645 AEH 0.9030
646 4J8 0.9030
647 7WG 0.9029
648 MWM 0.9029
649 HA5 0.9029
650 209 0.9028
651 JZ2 0.9028
652 DHK 0.9028
653 4JU 0.9028
654 PD2 0.9027
655 IUR 0.9026
656 3FH 0.9026
657 46P 0.9025
658 GJP 0.9024
659 M1E 0.9024
660 TWO 0.9023
661 EV0 0.9022
662 RAT 0.9021
663 XYS 0.9021
664 OW7 0.9020
665 HX4 0.9020
666 268 0.9019
667 XYD 0.9019
668 2H5 0.9019
669 F0J 0.9018
670 EKZ 0.9018
671 MZG 0.9018
672 7N0 0.9017
673 AGK 0.9017
674 4ZE 0.9017
675 AAS 0.9016
676 VOH 0.9016
677 PYD 0.9016
678 10L 0.9015
679 RJY 0.9014
680 NK 0.9014
681 LGC 0.9013
682 1HN 0.9012
683 492 0.9011
684 JBH 0.9011
685 B60 0.9009
686 4JO 0.9008
687 4JJ 0.9008
688 RMN 0.9006
689 1A7 0.9005
690 V55 0.9005
691 DS0 0.9004
692 KTJ 0.9004
693 CTS 0.9003
694 H33 0.9002
695 OMD 0.9002
696 4RU 0.9001
697 FPI 0.9001
698 R9S 0.8999
699 ONR 0.8998
700 2AC 0.8998
701 GIF 0.8997
702 34A 0.8997
703 MNM 0.8996
704 4XS 0.8994
705 DNF 0.8993
706 27Y 0.8993
707 IDH 0.8993
708 1P3 0.8992
709 TTY 0.8992
710 SR1 0.8991
711 0BP 0.8991
712 8NB 0.8991
713 BR9 0.8990
714 BNL 0.8988
715 DIU 0.8988
716 K32 0.8987
717 PRZ 0.8986
718 4XV 0.8986
719 A5E 0.8985
720 JBE 0.8984
721 2LP 0.8982
722 FBJ 0.8982
723 M58 0.8981
724 A1U 0.8980
725 5VL 0.8979
726 ZXD 0.8978
727 O72 0.8978
728 FBS 0.8978
729 149 0.8978
730 M4S 0.8977
731 4CL 0.8977
732 2MP 0.8977
733 6MP 0.8977
734 X0U 0.8976
735 RA7 0.8975
736 H4E 0.8974
737 PQK 0.8974
738 JKE 0.8973
739 JZ3 0.8972
740 FPY 0.8972
741 795 0.8971
742 J9N 0.8971
743 GLA 0.8971
744 NID 0.8970
745 1DV 0.8969
746 ZYR 0.8969
747 2MH 0.8969
748 Z5P 0.8968
749 N2Z 0.8965
750 4M4 0.8965
751 BK9 0.8962
752 GWM 0.8962
753 GYE 0.8962
754 3MG 0.8961
755 37T 0.8961
756 1LM 0.8961
757 JTH 0.8961
758 MAQ 0.8960
759 WOO 0.8959
760 27B 0.8958
761 2CQ 0.8957
762 BDF 0.8956
763 ESI 0.8956
764 QY9 0.8955
765 4I8 0.8955
766 CIT 0.8955
767 GJZ 0.8954
768 M45 0.8953
769 K22 0.8953
770 7NI 0.8953
771 MWJ 0.8953
772 TEP 0.8952
773 42C 0.8952
774 HBX 0.8952
775 2BX 0.8949
776 NF3 0.8949
777 QSC 0.8949
778 EUE 0.8949
779 PYF 0.8948
780 URS 0.8947
781 36E 0.8947
782 OXC 0.8947
783 Q6T 0.8946
784 FGZ 0.8946
785 3QM 0.8945
786 FBW 0.8945
787 8G0 0.8944
788 GAF 0.8944
789 2HC 0.8944
790 X0W 0.8943
791 30G 0.8942
792 FUL 0.8942
793 9RW 0.8941
794 PEL 0.8941
795 SMN 0.8940
796 5XB 0.8940
797 3R4 0.8939
798 9DA 0.8939
799 P3K 0.8939
800 KYA 0.8939
801 5JC 0.8939
802 LMR 0.8938
803 UNC 0.8938
804 TAG 0.8937
805 4FH 0.8937
806 1WD 0.8936
807 0R0 0.8936
808 2YU 0.8936
809 GO2 0.8936
810 P9E 0.8933
811 GUA 0.8933
812 BP1 0.8931
813 FRU 0.8931
814 OGA 0.8930
815 344 0.8929
816 ZZZ 0.8929
817 MAN 0.8928
818 OKG 0.8928
819 GIV 0.8928
820 7MX 0.8927
821 UEG 0.8926
822 OHG 0.8926
823 9FE 0.8925
824 JBQ 0.8924
825 K5W 0.8923
826 D3G 0.8922
827 DHQ 0.8922
828 TYE 0.8921
829 0LH 0.8920
830 DMJ 0.8917
831 2GS 0.8917
832 NSG 0.8916
833 GNL 0.8916
834 PPY 0.8916
835 DVQ 0.8915
836 7HP 0.8914
837 KW8 0.8913
838 BTE 0.8913
839 7WA 0.8913
840 IT2 0.8913
841 APZ 0.8911
842 2KA 0.8911
843 9HX 0.8911
844 LG4 0.8910
845 RIP 0.8910
846 ES4 0.8909
847 X6X 0.8909
848 MWP 0.8909
849 NDG 0.8909
850 TLA 0.8908
851 JND 0.8908
852 4SX 0.8907
853 P4B 0.8907
854 PXY 0.8906
855 5WY 0.8906
856 AMS 0.8903
857 7WV 0.8902
858 20J 0.8902
859 TAR 0.8901
860 8XL 0.8901
861 MAJ 0.8900
862 HQE 0.8900
863 GTR 0.8899
864 ORO 0.8899
865 PO6 0.8898
866 FHC 0.8898
867 DEE 0.8898
868 B5D 0.8896
869 G6D 0.8896
870 9KT 0.8895
871 3WA 0.8895
872 0MK 0.8895
873 SYN 0.8894
874 EYK 0.8893
875 BPY 0.8893
876 L3Q 0.8892
877 DOR 0.8892
878 ABN 0.8890
879 4V2 0.8889
880 PCR 0.8889
881 QSH 0.8888
882 S76 0.8886
883 92G 0.8885
884 PCA 0.8885
885 GLY GLY 0.8883
886 K17 0.8883
887 HPS 0.8882
888 DRG 0.8882
889 PM6 0.8882
890 GXL 0.8882
891 EQT 0.8880
892 1WG 0.8879
893 AJY 0.8878
894 KIB 0.8877
895 G3P 0.8877
896 G3H 0.8877
897 PXM 0.8877
898 0W1 0.8877