Receptor
PDB id Resolution Class Description Source Keywords
4J81 1.75 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF BETA'-COP/INSIG-1 COMPLEX SACCHAROMYCES CEREVISIAE BETA PROPELLER DOMAIN DILYSINE MOTIF COPI ER RETRIEVAL PTRANSPORT
Ref.: RULES FOR THE RECOGNITION OF DILYSINE RETRIEVAL MOT COATOMER. EMBO J. V. 32 926 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
LYS PRO HIS SER ASP C:1;
D:1;
Valid;
Valid;
none;
none;
submit data
582.615 n/a O=C([...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4J73 1.44 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF BETA'-COP/P25 COMPLEX SACCHAROMYCES CEREVISIAE BETA PROPELLER DILYSINE MOTIF ER RETRIEVAL SIGNAL COATOMERECOGNITION PROTEIN TRANSPORT
Ref.: RULES FOR THE RECOGNITION OF DILYSINE RETRIEVAL MOT COATOMER. EMBO J. V. 32 926 2013
Members (10)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 4J84 - ALA ARG LYS LEU ASP n/a n/a
2 4J77 - ALA LYS GLU LYS SER ASP n/a n/a
3 4J79 - GLU LYS VAL HIS VAL GLN n/a n/a
4 2YNO - ALA ALA ALA ALA ALA n/a n/a
5 4J73 - PHE GLU ALA LYS LYS LEU VAL n/a n/a
6 4J81 - LYS PRO HIS SER ASP n/a n/a
7 2YNN - CYS THR PHE LYS THR LYS THR ASN n/a n/a
8 4J78 - LYS THR LYS LEU LEU n/a n/a
9 4J82 - LYS SER HIS GLN GLU n/a n/a
10 4J86 - THR PHE LYS LYS THR ASN n/a n/a
70% Homology Family (10)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 4J84 - ALA ARG LYS LEU ASP n/a n/a
2 4J77 - ALA LYS GLU LYS SER ASP n/a n/a
3 4J79 - GLU LYS VAL HIS VAL GLN n/a n/a
4 2YNO - ALA ALA ALA ALA ALA n/a n/a
5 4J73 - PHE GLU ALA LYS LYS LEU VAL n/a n/a
6 4J81 - LYS PRO HIS SER ASP n/a n/a
7 2YNN - CYS THR PHE LYS THR LYS THR ASN n/a n/a
8 4J78 - LYS THR LYS LEU LEU n/a n/a
9 4J82 - LYS SER HIS GLN GLU n/a n/a
10 4J86 - THR PHE LYS LYS THR ASN n/a n/a
50% Homology Family (11)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 4J84 - ALA ARG LYS LEU ASP n/a n/a
2 4J77 - ALA LYS GLU LYS SER ASP n/a n/a
3 4J79 - GLU LYS VAL HIS VAL GLN n/a n/a
4 2YNO - ALA ALA ALA ALA ALA n/a n/a
5 4J73 - PHE GLU ALA LYS LYS LEU VAL n/a n/a
6 4J81 - LYS PRO HIS SER ASP n/a n/a
7 2YNN - CYS THR PHE LYS THR LYS THR ASN n/a n/a
8 4J78 - LYS THR LYS LEU LEU n/a n/a
9 4J82 - LYS SER HIS GLN GLU n/a n/a
10 4J86 - THR PHE LYS LYS THR ASN n/a n/a
11 4J8B - LEU LYS THR LYS LEU LEU n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: LYS PRO HIS SER ASP; Similar ligands found: 61
No: Ligand ECFP6 Tc MDL keys Tc
1 LYS PRO HIS SER ASP 1 1
2 LYS ARG ARG ARG HIS PRO SER GLY 0.529851 0.907692
3 LYS PRO ILE VAL VAL LEU HIS GLY TYR 0.527027 0.785714
4 LYS PRO LYS 0.524752 0.783333
5 TYR TYR SER ILE ILE PRO HIS SER ILE 0.510791 0.842857
6 LYS TYR TYR SER ILE ILE PRO HIS SER ILE 0.510791 0.842857
7 LYS ARG ARG ARG HIS PRO SER 0.5 0.861538
8 GLU LYS PRO SER SER SER 0.5 0.916667
9 SER ARG ASP HIS SER ARG THR PRO MET 0.496689 0.821918
10 GLY SER ASP PRO PHE LYS 0.496 0.918033
11 LYS SER HIS GLN GLU 0.491667 0.866667
12 GLY SER ASP PRO TRP LYS 0.488889 0.920635
13 THR LYS PRO ARG 0.482143 0.738462
14 HIS HIS ALA SER PRO ARG LYS 0.479167 0.835821
15 HIS PRO PHE 0.474138 0.822581
16 GLU ALA ASP PRO THR GLY HIS SER TYR 0.474026 0.895522
17 ILE LEU LYS GLU PRO VAL HIS GLY VAL 0.469799 0.830769
18 PRO PRO HIS SER TPO 0.469697 0.855072
19 LYS HIS LYS 0.46729 0.766667
20 VAL TYR PRO IAS HIS ALA 0.467153 0.823529
21 HIS ALA TPO PRO PRO LYS LYS GLU ALA ASP 0.464516 0.814286
22 ARG ALA HIS SEP SER PRO ALA SER LEU GLN 0.461538 0.830986
23 ACE PRO LEU HIS SER TPO 0.458015 0.783784
24 TYR TYR SER ILE ALA PRO HIS SER ILE 0.455782 0.816901
25 TYR LEU LYS GLU PRO VAL HIS GLY VAL 0.455128 0.797101
26 ASN TRP SER HIS PRO GLN PHE GLU LYS 0.454545 0.935484
27 DVA DPR GLY DSN DGN DHI DTY DAS DSN 0.453333 0.882353
28 DHI PRO PHE HIS LEU LEU VAL TYR 0.441558 0.757143
29 ALA ASN SER ARG HIS PRO THR SER ILE ILE 0.441379 0.842857
30 ABA SER LEU TRP ASN GLY PRO HIS LEU 0.43038 0.882353
31 ALA ARG SER HIS SEP TYR PRO ALA 0.43038 0.74359
32 TYR PRO ASN VAL ASN ILE HIS ASN PHE 0.428571 0.802817
33 ALA LEU PRO HIS ALA ILE LEU ARG LEU 0.427632 0.757143
34 ACE PRO LEU HIS SER TPO ALA NH2 0.427536 0.783784
35 TYR PRO SER LYS PRO ASP ASN PRO GLY GLU 0.426357 0.859375
36 PHE ASN GLU LEU SER HIS LEU 0.42623 0.765625
37 SER HIS PRO ARG PRO ILE ARG VAL 0.425676 0.842857
38 LYS PRO PHE PTR VAL ASN VAL GLU PHE 0.424051 0.723684
39 LYS PRO PHE PTR VAL ASN VAL NH2 0.422819 0.710526
40 ARG ILE ILE PRO ARG HIS LEU GLN LEU 0.422078 0.785714
41 SER PRO HIS ASN PRO ILE SER ASP VAL ASP 0.421875 0.861538
42 LEU PRO PHE ASP LYS SER THR ILE MET 0.421384 0.788732
43 SER PRO LEU ASP SER LEU TRP TRP ILE 0.42 0.84058
44 GLY GLN VAL PRO PHE SER LYS GLU GLU CYS 0.42 0.848485
45 HIS PRO 0.419048 0.85
46 LYS PRO ILE VAL GLN TYR ASP ASN PHE 0.417722 0.788732
47 GLU LEU PRO PRO VAL LYS ILE HIS CYS 0.417178 0.833333
48 ACE PRO LEU HIS SER TPO MET NH2 0.416667 0.753247
49 HIS SER LYS LYS LYS CYS ASP GLU LEU 0.416058 0.815385
50 ALA LYS PHE ARG HIS ASP 0.411765 0.705882
51 ACE PHE HIS PRO ALA NH2 0.410853 0.769231
52 VAL VAL SER HIS PHE ASN ASP 0.410448 0.753846
53 LEU PRO PHE GLU LYS SER THR VAL MET 0.410256 0.8
54 LYS PRO VAL LEU ARG THR ALA 0.408451 0.757143
55 SER THR GLY GLY VAL M3L LYS PRO HIS ARG 0.408046 0.776316
56 1IP CYS PHE SER LYS PRO ARG 0.405229 0.84058
57 SER SER CYS PRO LEU SER LYS 0.40458 0.815385
58 ACE ASP PRO PRO LEU HIS SER TPO ALA NH2 0.402685 0.805556
59 ACE ALA PRO GLN VAL STA VAL MET HIS PRO 0.401274 0.828571
60 PRO LYS LEU GLU PRO TRP LYS HIS PRO 0.4 0.820895
61 LYS PRO 0.4 0.783333
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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