Receptor
PDB id Resolution Class Description Source Keywords
4J78 1.48 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF BETA'-COP/EMP47P COMPLEX SACCHAROMYCES CEREVISIAE BETA PROPELLER DOMAIN DILYSINE MOTIF ER RETRIEVAL PROTEINTRANSPORT
Ref.: RULES FOR THE RECOGNITION OF DILYSINE RETRIEVAL MOT COATOMER. EMBO J. V. 32 926 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
LYS THR LYS LEU LEU B:1;
Valid;
none;
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603.806 n/a O=C([...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4J73 1.44 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF BETA'-COP/P25 COMPLEX SACCHAROMYCES CEREVISIAE BETA PROPELLER DILYSINE MOTIF ER RETRIEVAL SIGNAL COATOMERECOGNITION PROTEIN TRANSPORT
Ref.: RULES FOR THE RECOGNITION OF DILYSINE RETRIEVAL MOT COATOMER. EMBO J. V. 32 926 2013
Members (10)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 4J84 - ALA ARG LYS LEU ASP n/a n/a
2 4J77 - ALA LYS GLU LYS SER ASP n/a n/a
3 4J79 - GLU LYS VAL HIS VAL GLN n/a n/a
4 2YNO - ALA ALA ALA ALA ALA n/a n/a
5 4J73 - PHE GLU ALA LYS LYS LEU VAL n/a n/a
6 4J81 - LYS PRO HIS SER ASP n/a n/a
7 2YNN - CYS THR PHE LYS THR LYS THR ASN n/a n/a
8 4J78 - LYS THR LYS LEU LEU n/a n/a
9 4J82 - LYS SER HIS GLN GLU n/a n/a
10 4J86 - THR PHE LYS LYS THR ASN n/a n/a
70% Homology Family (10)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 4J84 - ALA ARG LYS LEU ASP n/a n/a
2 4J77 - ALA LYS GLU LYS SER ASP n/a n/a
3 4J79 - GLU LYS VAL HIS VAL GLN n/a n/a
4 2YNO - ALA ALA ALA ALA ALA n/a n/a
5 4J73 - PHE GLU ALA LYS LYS LEU VAL n/a n/a
6 4J81 - LYS PRO HIS SER ASP n/a n/a
7 2YNN - CYS THR PHE LYS THR LYS THR ASN n/a n/a
8 4J78 - LYS THR LYS LEU LEU n/a n/a
9 4J82 - LYS SER HIS GLN GLU n/a n/a
10 4J86 - THR PHE LYS LYS THR ASN n/a n/a
50% Homology Family (11)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 4J84 - ALA ARG LYS LEU ASP n/a n/a
2 4J77 - ALA LYS GLU LYS SER ASP n/a n/a
3 4J79 - GLU LYS VAL HIS VAL GLN n/a n/a
4 2YNO - ALA ALA ALA ALA ALA n/a n/a
5 4J73 - PHE GLU ALA LYS LYS LEU VAL n/a n/a
6 4J81 - LYS PRO HIS SER ASP n/a n/a
7 2YNN - CYS THR PHE LYS THR LYS THR ASN n/a n/a
8 4J78 - LYS THR LYS LEU LEU n/a n/a
9 4J82 - LYS SER HIS GLN GLU n/a n/a
10 4J86 - THR PHE LYS LYS THR ASN n/a n/a
11 4J8B - LEU LYS THR LYS LEU LEU n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: LYS THR LYS LEU LEU; Similar ligands found: 104
No: Ligand ECFP6 Tc MDL keys Tc
1 LYS THR LYS LEU LEU 1 1
2 LEU LYS THR LYS LEU LEU 0.805556 1
3 LYS THR LYS 0.676471 0.933333
4 ILE LYS LEU GLU THR LYS LYS THR LYS LEU 0.658228 0.918367
5 LYS LEU LYS 0.614286 0.888889
6 LYS LEU VAL GLN LEU LEU THR THR THR 0.602273 0.93617
7 LEU THR THR LYS LEU THR ASN THR ASN ILE 0.588889 0.88
8 HIS GLU GLU LEU ALA LYS LEU 0.573171 0.847826
9 SER LEU LYS LEU MET THR THR VAL 0.566667 0.862745
10 GLY THR LEU SER ASN ARG ALA SER LYS LEU 0.555556 0.934783
11 LYS ASN LEU 0.546667 0.87234
12 PHE GLU ALA LYS LYS LEU VAL 0.54321 0.888889
13 LYS LYS LYS ALA 0.534247 0.822222
14 LYS LYS LYS 0.528571 0.8
15 ARG ASP ARG ALA ALA LYS LEU 0.522727 0.784314
16 LYS VAL LYS 0.513514 0.866667
17 LYS ILE LYS 0.513158 0.847826
18 LYS SER LEU LEU GLN GLN LEU LEU THR GLU 0.51 0.9375
19 ALA THR LYS ILE ASP ASN LEU ASP 0.504951 0.88
20 LYS LEU THR PRO LEU CYS VAL THR LEU 0.504587 0.762712
21 LYS NLE LYS 0.493333 0.808511
22 CYS THR GLU LEU LYS LEU ASN ASP TYR 0.491071 0.8
23 LYS VAL ILE THR PHE ILE ASP LEU 0.490741 0.862745
24 SER LEU LEU LYS LYS LEU LEU ASP 0.488372 0.916667
25 SER LEU LEU LYS LYS LEU LEU LEU ALA 0.487805 0.934783
26 CYS THR GLU LEU LYS LEU SER ASP TYR 0.486726 0.8
27 ALA ARG THR LYS GLN THR ALA ARG LYS SER 0.482353 0.891304
28 LYS NVA LYS 0.48 0.826087
29 ALA ARG LYS LEU ASP 0.477778 0.788462
30 HIS LYS LEU VAL GLN LEU LEU THR THR THR 0.477064 0.789474
31 LYS DAB LYS 0.472973 0.804348
32 LEU LEU LEU 0.471429 0.711111
33 LYS GLY PRO PRO ALA ALA LEU THR LEU 0.470085 0.75
34 ACE CSO ARG ALA THR LYS MET LEU 0.468468 0.703125
35 GLU THR LEU LEU ASP LEU ASP PHE LEU GLU 0.466667 0.8125
36 LYS ALA LYS 0.466667 0.822222
37 GLU ALA GLN THR ARG LEU 0.466019 0.826923
38 LYS LYS 0.463768 0.777778
39 ALA PRO ALA LEU ARG VAL VAL LYS 0.463158 0.784314
40 ILE LEU ALA LYS PHE LEU HIS THR LEU 0.462185 0.775862
41 ACE GLN LEU VAL THR SER LEU 0.461538 0.836735
42 TYR GLN SER LYS LEU 0.459184 0.830189
43 ACE VAL LYS GLU SER LEU VAL 0.457447 0.914894
44 ARG LEU GLN ARG ARG ARG GLU THR GLN VAL 0.451923 0.830189
45 CYS THR PHE LYS THR LYS THR ASN 0.45098 0.826923
46 LYS MET LYS 0.45 0.77551
47 LYS GLU LYS 0.448718 0.782609
48 LYS SER LYS 0.447368 0.869565
49 PRO LYS THR PRO LYS LYS ALA LYS LYS LEU 0.443038 0.844444
50 LYS GLN LYS 0.443038 0.782609
51 ALA LEU LYS ILE ASP ASN LEU ASP 0.441176 0.82
52 THR ARG ARG GLU THR GLN LEU 0.44 0.830189
53 LYS DPP LYS 0.44 0.826087
54 ASN SER THR LEU GLN 0.43956 0.816327
55 LYS ALA VAL TYR ASN LEU ALA THR MET 0.438017 0.758621
56 ALA ARG THR GLU LEU TYR ARG SER LEU 0.435897 0.733333
57 ASP GLU LEU GLU ILE LYS ALA TYR 0.434783 0.811321
58 LYS ORN LYS 0.432099 0.765957
59 ALA ASP LYS ILE ASP ASN LEU ASP 0.431373 0.82
60 THR PHE LYS LYS THR ASN 0.43 0.843137
61 ARG ARG ALA THR LYS MET NH2 0.428571 0.767857
62 LYS CYS LYS 0.428571 0.804348
63 ALA LYS 0.428571 0.777778
64 LYS ALA THR LYS MLY 0.428571 0.865385
65 LYS ARG LYS 0.428571 0.705882
66 LYS ALA LEU TYR ASN PHE ALA THR MET 0.427419 0.733333
67 ALA LEU ALA LEU 0.426667 0.711111
68 ASN LEU LEU GLN LYS LYS 0.425532 0.851064
69 SER LEU LYS ILE ASP ASN LEU ASP 0.424528 0.843137
70 LYS VAL LEU PHE LEU ASP GLY 0.424528 0.8
71 LYS SER LYS THR CMT GER 0.424528 0.833333
72 LYS ASP LYS 0.423077 0.804348
73 GLU ALA THR GLN LEU MET ASN 0.423077 0.82
74 THR LYS ASN TYR LYS GLN THR SER VAL 0.422414 0.8
75 LYS LEU LEU PHE 0.422222 0.770833
76 LYS PRO VAL LEU ARG THR ALA 0.420168 0.714286
77 SER LEU ALA ASN THR VAL ALA THR LEU 0.42 0.795918
78 THR LYS THR ALA THR ILE ASN ALA SER 0.419048 0.86
79 ASP LEU LYS ILE ASP ASN LEU ASP 0.419048 0.82
80 LYS ASN LYS 0.417722 0.808511
81 GLU ILE ILE ASN PHE GLU LYS LEU 0.417391 0.823529
82 SER GLU LEU GLU ILE LYS ARG TYR 0.416667 0.75
83 GLY GLY LYS LYS LYS TYR LYS LEU 0.415842 0.792453
84 SER ASP LYS ILE ASP ASN LEU ASP 0.415094 0.843137
85 ALA ARG THR LYS GLN THR ALA ARG 0.414141 0.807692
86 ALA THR PRK ALA ALA ARG LYS SER 0.414141 0.857143
87 PHE PRO THR LYS ASP VAL ALA LEU 0.414062 0.737705
88 SER LEU TYR LEU THR VAL ALA THR LEU 0.411215 0.735849
89 VAL THR THR ASP ILE GLN VAL LYS VAL 0.411215 0.916667
90 GLN PHE LYS ASP ASN VAL ILE LEU LEU 0.409836 0.773585
91 SER GLN LEU LYS ASN ASN ALA LYS GLU ILE 0.409091 0.862745
92 PHE LEU SER THR LYS 0.407767 0.86
93 GLY ILE ILE ASN THR LEU 0.406593 0.836735
94 SER ALA LYS ILE ASP ASN LEU ASP 0.405405 0.843137
95 ALA LEU LYS ILE ASP ASN MET ASP 0.405405 0.759259
96 ALA ALA LEU THR ARG ALA 0.40404 0.823529
97 ILE PRO LEU THR GLU GLU ALA GLU LEU 0.403509 0.745763
98 ALA LEU 0.402985 0.644444
99 THR LYS CYS VAL VAL MET 0.402062 0.88
100 ACE GLU ALA GLN THR ARG LEU 0.401869 0.811321
101 SER LEU LYS ILE ASP ASN GLU ASP 0.401786 0.843137
102 SER ILE ILE ASN PHE GLU LYS LEU 0.401709 0.811321
103 LYS ALA SER VAL GLY 0.4 0.893617
104 ALA LYS GLU LYS SER ASP 0.4 0.854167
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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