Receptor
PDB id Resolution Class Description Source Keywords
4J25 1.97 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF A PSEUDOMONAS PUTIDA PROLYL-4-HYDROXYLA PSEUDOMONAS PUTIDA 2-OXOGLUTARATE OXYGENASE OXYGEN SENSING DOUBLE-STRANDED BEJELLYROLL FOLD PROLYL-4-HYDROXYLASE OXIDOREDUCTASE
Ref.: HUMAN OXYGEN SENSING MAY HAVE ORIGINS IN PROKARYOTI ELONGATION FACTOR TU PROLYL-HYDROXYLATION PROC.NATL.ACAD.SCI.USA V. 111 13331 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
OGA H:402;
G:402;
C:402;
A:402;
F:402;
D:402;
E:402;
B:402;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
147.086 C4 H5 N O5 C(C(=...
MN D:401;
H:401;
B:401;
C:401;
A:401;
E:401;
F:401;
G:401;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
54.938 Mn [Mn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4J25 1.97 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF A PSEUDOMONAS PUTIDA PROLYL-4-HYDROXYLA PSEUDOMONAS PUTIDA 2-OXOGLUTARATE OXYGENASE OXYGEN SENSING DOUBLE-STRANDED BEJELLYROLL FOLD PROLYL-4-HYDROXYLASE OXIDOREDUCTASE
Ref.: HUMAN OXYGEN SENSING MAY HAVE ORIGINS IN PROKARYOTI ELONGATION FACTOR TU PROLYL-HYDROXYLATION PROC.NATL.ACAD.SCI.USA V. 111 13331 2014
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 4J25 - OGA C4 H5 N O5 C(C(=O)O)N....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 4J25 - OGA C4 H5 N O5 C(C(=O)O)N....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 4J25 - OGA C4 H5 N O5 C(C(=O)O)N....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: OGA; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 OGA 1 1
2 AAC 0.461538 0.827586
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4J25; Ligand: OGA; Similar sites found: 129
This union binding pocket(no: 1) in the query (biounit: 4j25.bio8) has 13 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1VYF OLA 0.02939 0.40508 None
2 5CLO NS8 0.007459 0.40134 None
3 3VHH VHH 0.004465 0.4792 1.31004
4 4GJY OGA 0.000006151 0.56421 1.74672
5 2C4I BTN 0.02011 0.40331 1.74672
6 5FP3 3JI 0.0002873 0.50812 2.18341
7 5A3T MMK 0.0006191 0.50293 2.18341
8 3P3N AKG 0.0001003 0.50055 2.18341
9 2XUM OGA 0.00009947 0.48577 2.18341
10 4B7E OGA 0.0002356 0.48308 2.18341
11 2Y0I AKG 0.0002497 0.4818 2.18341
12 2WA4 069 0.00002367 0.4807 2.18341
13 1OS7 AKG 0.00006711 0.42219 2.18341
14 1OS7 TAU 0.00006711 0.42219 2.18341
15 1ZOA 140 0.03001 0.41882 2.18341
16 1GT4 UNA 0.01409 0.41164 2.18341
17 2NNQ T4B 0.01889 0.43146 2.29008
18 1NX4 AKG 0.0000622 0.51135 2.62009
19 5C3R AKG 0.0000008348 0.50064 2.62009
20 5C3R HMU 0.0000008348 0.50064 2.62009
21 3PUR 2HG 0.0009465 0.45517 2.62009
22 3N9P OGA 0.001505 0.43267 2.62009
23 3N9O OGA 0.00152 0.4325 2.62009
24 3N9Q OGA 0.001556 0.43202 2.62009
25 1GQG DCD 0.02367 0.40746 2.62009
26 1XPK HMG 0.04032 0.40221 2.62009
27 3ML5 AZM 0.011 0.40218 2.62009
28 4UF0 MMK 0.001689 0.45477 3.05677
29 3NW7 LGV 0.04568 0.41369 3.05677
30 2OG7 SIN 0.00005834 0.47906 3.08123
31 1WBI BTN 0.005322 0.43024 3.10078
32 4NAO AKG 0.0001778 0.45895 3.49345
33 5MW4 5JU 0.02958 0.42321 3.49345
34 2QM9 TDZ 0.02733 0.40454 3.87097
35 2A1X AKG 0.000005877 0.5036 3.8961
36 1OIK C26 0.00002241 0.55367 3.93013
37 1OIK AKG 0.00000346 0.55291 3.93013
38 1OIJ AKG 0.000005849 0.52269 3.93013
39 5F3I 5UJ 0.001316 0.50829 3.93013
40 5LY2 OGA 0.0005557 0.4526 3.93013
41 2Q8C AKG 0.001068 0.45117 3.93013
42 2OS2 OGA 0.001413 0.44613 3.93013
43 5FWE OGA 0.0008773 0.44278 3.93013
44 2Q8E OGA 0.001686 0.44163 3.93013
45 2XIQ MLC 0.008843 0.44028 3.93013
46 2YBP 2HG 0.001956 0.4393 3.93013
47 2P5B OGA 0.003513 0.43708 3.93013
48 4BJ8 BTN 0.01341 0.41253 3.96825
49 5IVE 6E8 0.004631 0.45528 4.36681
50 4QJP V1F 0.02861 0.40617 4.36681
51 3ZW2 GLA NAG GAL FUC 0.004826 0.43633 4.5977
52 3ZW2 NAG GAL FUC 0.006117 0.42666 4.5977
53 3ZW2 GAL FUC 0.00608 0.42445 4.5977
54 5A65 TPP 0.01632 0.41363 4.60829
55 1Y52 BTN 0.002886 0.47946 4.7619
56 4XCB HY0 0.000008575 0.59583 4.80349
57 4XCB AKG 0.000001873 0.59132 4.80349
58 4Y3O OGA 0.00002443 0.51476 4.80349
59 4CCK OGA 0.00003022 0.51091 4.80349
60 4CCO OGA 0.00006136 0.49883 4.80349
61 3AMN CBK 0.01088 0.43064 4.80349
62 3AMN CBI 0.01088 0.43064 4.80349
63 3EW2 BTN 0.01098 0.40818 5.18518
64 4OCT AKG 0.0000007973 0.55474 5.24017
65 1GP6 DH2 0.00004657 0.55225 5.24017
66 1GP6 QUE 0.00005072 0.55225 5.24017
67 1GP6 SIN 0.00004657 0.55225 5.24017
68 4P7X YCP 0.00003104 0.5495 5.24017
69 4P7X AKG 0.00003104 0.5495 5.24017
70 4BG1 IVL 0.0006672 0.48708 5.24017
71 4D52 GIV 0.001767 0.4166 5.24017
72 4D4U FUC NDG GAL FUC 0.005473 0.40624 5.24017
73 4D4U FUC GAL NDG FUC 0.01402 0.40402 5.24017
74 1N5S ADL 0.006098 0.43009 5.35714
75 2ZSC BTN 0.006115 0.42772 5.67376
76 4NPL AKG 0.0000007424 0.60595 5.67686
77 4BXF AKG 0.00001745 0.53914 5.67686
78 4B1M FRU FRU 0.004668 0.40965 5.67686
79 5MBC FMN 0.01921 0.40453 6.11354
80 4V24 GYR 0.009412 0.43221 6.55022
81 5EQU 5R6 0.0287 0.42141 6.55022
82 5EQU AKG 0.01024 0.42141 6.55022
83 1QY1 PRZ 0.02392 0.40512 6.89655
84 5JSP DQY 0.001504 0.44442 6.96517
85 3PQB VGP 0.006396 0.43757 6.9869
86 5KR7 6X9 0.005336 0.42773 6.9869
87 4BCS BTN 0.003692 0.44113 7.2
88 1WUB OTP 0.02111 0.4306 7.30337
89 4RFR RHN 0.000003486 0.60116 7.42358
90 2FCU AKG 0.000008707 0.55373 7.42358
91 4IYO 0JO 0.01751 0.41193 7.42358
92 5HV0 AKG 0.0000000007437 0.78057 7.86026
93 5FWJ MMK 0.0005971 0.4704 7.86026
94 2C1Q BTN 0.0006143 0.40451 7.93651
95 1DRY AKG 0.00002428 0.57315 8.29694
96 1DRY AAG 0.00002428 0.57315 8.29694
97 5ML3 DL3 0.01214 0.43852 8.72483
98 2ET1 GLV 0.0002638 0.48344 8.95522
99 2IUW AKG 0.0000005447 0.62115 9.17031
100 4QXB OGA 0.0008437 0.46379 9.17031
101 3KV4 OGA 0.001266 0.44872 9.17031
102 4EKV BTN 0.01908 0.40067 9.43396
103 3AVS OGA 0.00003742 0.53048 9.60699
104 3AVR OGA 0.00003295 0.52552 9.60699
105 5I0U DCY 0.0004209 0.47961 9.60699
106 4LIT AKG 0.001094 0.45027 10.0437
107 4M26 SIN 0.0008964 0.48723 10.4803
108 4M26 AKG 0.0003954 0.47182 10.4803
109 3OPT AKG 0.005019 0.41857 10.917
110 4CCN OGA 0.00001587 0.54463 11.4286
111 1H2M OGA 0.00008092 0.50552 11.5385
112 2RDQ AKG 0.000001882 0.4546 12.6638
113 4OJ8 AKG 0.00002164 0.43787 12.6638
114 4QM9 CYS 0.002041 0.42646 12.6638
115 4OJ8 2TQ 0.00002661 0.42082 12.6638
116 5U98 1KX 0.0326 0.43009 13.1313
117 1UNB AKG 0.000001026 0.42815 13.5371
118 1UNB PN1 0.000001222 0.41496 13.5371
119 5TFZ 7BC 0.0002732 0.48916 14
120 4Z3X MTE 0.03564 0.43067 14.5251
121 4Z3X 4KX 0.0373 0.43067 14.5251
122 1H2K OGA 0.00007574 0.50701 14.6341
123 1ODM ASV 0.00002877 0.56404 15.7205
124 2JIG PD2 0.000000000923 0.76016 22.2707
125 4IE6 UN9 0.000009322 0.40077 29.2576
126 3HQR OGA 0.0000000007815 0.77495 38.8646
127 4JZR 4JR 0.000001254 0.55556 38.8646
128 4BQY FNT 0.000000002632 0.55273 42.3581
129 5C5T AKG 0.000000007744 0.6541 43.2314
Pocket No.: 2; Query (leader) PDB : 4J25; Ligand: OGA; Similar sites found: 21
This union binding pocket(no: 2) in the query (biounit: 4j25.bio1) has 13 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4Q0L V14 0.02551 0.40986 2.18341
2 4CSD MFU 0.003878 0.42379 2.62009
3 3U2U UDP 0.03644 0.40819 2.62009
4 3FW4 CAQ 0.02034 0.4155 2.80899
5 2ARC ARA 0.004235 0.42862 3.49345
6 5U3B 7TD 0.02087 0.41849 3.49345
7 4XBT FLC 0.02044 0.40041 3.87097
8 1OFZ FUL 0.002545 0.4213 3.93013
9 2WBP ZZU 0.0001353 0.40399 4.36681
10 2WBP SIN 0.0001353 0.40399 4.36681
11 5TDF ADP 0.02621 0.40196 4.80349
12 3AI7 TPP 0.03485 0.40307 5.67686
13 1ND2 MYR 0.0199 0.40074 5.67686
14 1KBJ FMN 0.03858 0.40097 8.29694
15 4QDF 30Q 0.02034 0.40306 8.73362
16 5FR0 SIZ 0.01276 0.40847 10.0437
17 1ZTH ADP 0.01539 0.40285 10.0437
18 1ZP9 ATP 0.02052 0.40271 10.0437
19 3RDO BTN 0.006096 0.42689 10.4575
20 3SAO NKN 0.01453 0.40859 13.75
21 5D48 L96 0.04116 0.40054 13.8158
Pocket No.: 3; Query (leader) PDB : 4J25; Ligand: OGA; Similar sites found: 8
This union binding pocket(no: 3) in the query (biounit: 4j25.bio6) has 14 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3GGU 017 0.03811 0.40265 None
2 1LN1 DLP 0.01368 0.43132 2.33645
3 3ZW0 FUC 0.007852 0.40207 4.5977
4 5HES 032 0.009391 0.42587 5.24017
5 2E56 MYR 0.02565 0.41431 6.94444
6 3SCM LGN 0.01607 0.44556 6.9869
7 1OGZ EQU 0.009218 0.41438 9.17031
8 4X6F 3XU 0.04163 0.41114 12.381
Pocket No.: 4; Query (leader) PDB : 4J25; Ligand: OGA; Similar sites found: 12
This union binding pocket(no: 4) in the query (biounit: 4j25.bio7) has 15 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4FFG 0U8 0.009745 0.41564 2.62009
2 4FFG LBS 0.004533 0.40867 2.62009
3 2RHW C0E 0.02862 0.4065 2.62009
4 1MI3 NAD 0.04005 0.40116 2.62009
5 2CER PGI 0.02653 0.40942 5.24017
6 1VJY 460 0.01112 0.43035 6.9869
7 2B4G FMN 0.03175 0.40164 6.9869
8 5B4B LP5 0.02415 0.41035 7.66129
9 3MJY FMN 0.03379 0.40617 9.60699
10 3MJY IJZ 0.03379 0.40617 9.60699
11 2CET PGI 0.0268 0.40674 10.917
12 4H6B 10Y 0.009677 0.40373 10.917
Pocket No.: 5; Query (leader) PDB : 4J25; Ligand: OGA; Similar sites found: 10
This union binding pocket(no: 5) in the query (biounit: 4j25.bio2) has 13 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2QL9 CIT 0.004192 0.4018 3.46821
2 4AZP A9M 0.01808 0.41717 4.34783
3 1KQW RTL 0.02327 0.40119 4.47761
4 1DMY AZM 0.01357 0.40197 4.80349
5 2YNE YNE 0.0452 0.43331 6.55022
6 2YNE NHW 0.0452 0.43331 6.55022
7 5FLJ QUE 0.0256 0.40617 6.98925
8 5UIU 8CG 0.01883 0.42542 8.29694
9 5MY8 RXZ 0.03894 0.40036 8.29694
10 4HP0 NOJ NAG NAG NAG 0.03419 0.40574 14.7287
Pocket No.: 6; Query (leader) PDB : 4J25; Ligand: OGA; Similar sites found: 7
This union binding pocket(no: 6) in the query (biounit: 4j25.bio4) has 13 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5BVT PAM 0.02959 0.40088 None
2 3E9I XAH 0.04093 0.40252 3.49345
3 1WLE SRP 0.01635 0.41191 3.93013
4 4XYM A12 0.0135 0.41579 5.67686
5 1Y0G 8PP 0.04812 0.41075 6.80628
6 4DE9 VTP 0.01079 0.4357 9.17031
7 3DG6 MUC 0.0179 0.4034 13.1004
Pocket No.: 7; Query (leader) PDB : 4J25; Ligand: OGA; Similar sites found: 7
This union binding pocket(no: 7) in the query (biounit: 4j25.bio3) has 13 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1ERB ETR 0.03057 0.40738 2.73224
2 2QCS ANP 0.03939 0.40092 3.05677
3 4F9C 0SX 0.01262 0.41473 5.55556
4 2XK9 XK9 0.04378 0.40721 5.67686
5 5I0F GLC GLC 0.01974 0.40705 6.55022
6 2TPS TPS 0.03932 0.40166 6.60793
7 3DBX PLM 0.01975 0.40056 13.1313
Pocket No.: 8; Query (leader) PDB : 4J25; Ligand: OGA; Similar sites found: 11
This union binding pocket(no: 8) in the query (biounit: 4j25.bio5) has 15 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5OO5 UUA 0.01604 0.40222 None
2 5D9O BGC BGC BGC BGC 0.04775 0.40222 3.05677
3 1T27 PCW 0.01876 0.42871 3.49345
4 3S7O LBV 0.01752 0.42004 3.49345
5 4B7P 9UN 0.02161 0.42797 3.93013
6 1LRH NLA 0.005381 0.4185 6.13497
7 4QYN RTL 0.007215 0.42327 8.27068
8 3ROE THM 0.01087 0.40131 9.17031
9 2GJ5 VD3 0.03427 0.40997 9.25926
10 3ZGJ RMN 0.01387 0.40074 10.0437
11 5L2J 6UL 0.0341 0.42814 13.2653
Feedback