Receptor
PDB id Resolution Class Description Source Keywords
4IKN 1.85 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF ADAPTOR PROTEIN COMPLEX 3 (AP-3) MU3A S TERMINAL DOMAIN, IN COMPLEX WITH A SORTING PEPTIDE FROM TGN RATTUS NORVEGICUS IMMUNOGLOBULIN-LIKE BETA-SANDWICH SIGNAL RECOGNITION CYTOSOF TRANSMEMBRANE PROTEINS ADAPTOR PROTEIN PROTEIN TRANSPO
Ref.: STRUCTURAL BASIS FOR THE RECOGNITION OF TYROSINE-BA SORTING SIGNALS BY THE MU 3A SUBUNIT OF THE AP-3 AD COMPLEX. J.BIOL.CHEM. V. 288 9563 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SER ASP TYR GLN ARG LEU B:1;
 Valid;
 none;
 Kd = 14 uM
692.751 n/a O=C([...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4IKN 1.85 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF ADAPTOR PROTEIN COMPLEX 3 (AP-3) MU3A S TERMINAL DOMAIN, IN COMPLEX WITH A SORTING PEPTIDE FROM TGN RATTUS NORVEGICUS IMMUNOGLOBULIN-LIKE BETA-SANDWICH SIGNAL RECOGNITION CYTOSOF TRANSMEMBRANE PROTEINS ADAPTOR PROTEIN PROTEIN TRANSPO
Ref.: STRUCTURAL BASIS FOR THE RECOGNITION OF TYROSINE-BA SORTING SIGNALS BY THE MU 3A SUBUNIT OF THE AP-3 AD COMPLEX. J.BIOL.CHEM. V. 288 9563 2013
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 4IKN Kd = 14 uM SER ASP TYR GLN ARG LEU n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 4IKN Kd = 14 uM SER ASP TYR GLN ARG LEU n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 4IKN Kd = 14 uM SER ASP TYR GLN ARG LEU n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: SER ASP TYR GLN ARG LEU; Similar ligands found: 138
No: Ligand ECFP6 Tc MDL keys Tc
1 SER ASP TYR GLN ARG LEU 1 1
2 GLY GLY LYS LYS ARG TYR LYS LEU 0.614679 0.929825
3 GLY GLY LYS LYS LYS TYR ARG LEU 0.614679 0.929825
4 GLY GLY ARG LYS LYS TYR LYS LEU 0.614679 0.929825
5 ALA ARG THR GLU LEU TYR ARG SER LEU 0.59322 0.915254
6 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.590164 0.915254
7 ARG ARG ILE TYR ASP LEU ILE GLU LEU 0.581967 0.947368
8 SER SER ARG LYS GLU TYR TYR ALA 0.577982 0.87931
9 ASN ALA LEU LEU ARG TYR LEU LEU ASP 0.570175 0.947368
10 ARG GLY TYR LEU TYR GLN GLY LEU 0.568965 0.929825
11 GLY GLY LYS LYS LYS TYR GLN LEU 0.568807 0.824561
12 PHE ARG TYR LEU GLY 0.558559 0.929825
13 VAL LYS VAL VAL ALA LYS LYS TYR ARG ASN 0.548673 0.913793
14 ARG GLY TYR VAL TYR GLN GLY LEU 0.545455 0.929825
15 GLU LEU ARG ARG LYS MET MET TYR MET 0.53719 0.868852
16 SER GLN TYR TYR TYR ASN SER LEU 0.537037 0.754098
17 THR ARG ARG GLU THR GLN LEU 0.53271 0.827586
18 ASP ASN ARG LEU GLY LEU VAL TYR GLN PHE 0.53271 0.767857
19 PHE TYR ARG ALA LEU MET 0.52459 0.866667
20 SER LEU ARG PHE LEU TYR GLU GLY 0.52459 0.9
21 ARG ARG LEU LEU ARG GLY HIS ASN GLN TYR 0.518797 0.830769
22 GLU ASN GLN LYS GLU TYR PHE PHE 0.517857 0.733333
23 ALA GLN ASP ILE TYR ARG ALA SER TYR 0.515152 0.868852
24 TYR GLN SER LYS LEU 0.509259 0.827586
25 ALA ARG THR MLY GLN THR ALA ARG TYR 0.508065 0.818182
26 THR ASN GLU PHE TYR PHE 0.504854 0.689655
27 GLY ASN PHE LEU GLN SER ARG 0.504132 0.833333
28 THR ASN GLU TYR TYR VAL 0.5 0.741379
29 GLU LEU LYS ARG LYS MET ILE TYR MET 0.5 0.868852
30 ASP ALA ASP GLU TYR LEU 0.5 0.8
31 ARG VAL ALA GLN LEU GLU GLN VAL TYR ILE 0.496124 0.963636
32 SER GLU LEU GLU ILE LYS ARG TYR 0.496063 0.9
33 THR ASN GLU TYR LYS VAL 0.495495 0.824561
34 GLY GLY LYS LYS LYS TYR LYS LEU 0.495413 0.824561
35 PHE TYR ARG TYR GLY PHE VAL ALA ASN PHE 0.495413 0.839286
36 PHE LEU ARG GLY ARG ALA TYR GLY LEU 0.492063 0.913793
37 LEU ARG ASN GLN SER VAL PHE ASN PHE 0.492063 0.836066
38 ACE GLU ALA GLN THR ARG LEU 0.491228 0.842105
39 ACE ILE TYR GLU SER LEU 0.490909 0.775862
40 GLU LEU ASN ARG LYS MET ILE TYR MET 0.489209 0.857143
41 GLU ALA GLN THR ARG LEU 0.486957 0.857143
42 TYR ASP GLN ILE LEU 0.481818 0.8
43 SER GLU ILE GLU PHE ALA ARG LEU 0.480315 0.862069
44 LEU TYR LEU VAL CYS GLY GLU ARG VAL 0.477612 0.929825
45 PHE LEU ARG GLY ARG ALA TYR VAL LEU 0.477612 0.913793
46 SER SER LEU GLU ASN PHE ARG ALA TYR VAL 0.475177 0.885246
47 ALA ASN SER ARG TRP GLN ASP THR ARG LEU 0.475177 0.776119
48 ALA GLN PHE SER ALA SER ALA SER ARG 0.470085 0.827586
49 SER SER ILE GLU PHE ALA ARG LEU 0.469231 0.847458
50 LEU TYR LEU VAL CYS GLY GLU ARG GLY PHE 0.467626 0.898305
51 GLU LEU LYS TPO GLU ARG TYR 0.466165 0.830769
52 ASP VAL GLN THR GLY ARG ARG PRO TYR GLU 0.465278 0.757143
53 LEU TYR LEU VAL CYS GLY GLU ARG GLY 0.462687 0.929825
54 ASP ALA GLU PHE ARG HIS ASP 0.462185 0.87037
55 GLY ALA ALA ARG ALA GLU VAL TYR LEU ARG 0.455882 0.929825
56 ARG ARG GLU VAL HIS THR TYR TYR 0.452555 0.80303
57 PHE GLU ASP LEU ARG LEU LEU SER PHE 0.452381 0.833333
58 ALA TYR ARG 0.451923 0.888889
59 ARG HIS ARG MLY VAL LEU ARG ASP TYR 0.450704 0.760563
60 GLU THR VAL ARG PHE GLN SER ASP 0.450382 0.877193
61 ARG PHE MET ASP TYR TRP GLU GLY LEU 0.447368 0.80597
62 THR PRO ASP TYR PHE LEU 0.447368 0.774194
63 THR PHE GLN ALA PSA LEU ARG GLU 0.446809 0.836066
64 LYS LYS ALA THR GLN ALA SEP GLN GLU TYR 0.445455 0.6875
65 ARG LYS LYS ARG TYR THR VAL VAL GLY ASN 0.444444 0.852459
66 ASP LEU TYR CYS TYR GLU GLN LEU ASN 0.443548 0.783333
67 SER SER ARG THR ARG ARG GLU GLU GLN LEU 0.44086 0.666667
68 GLU LEU ARG SER ARG TYR TRP ALA ILE 0.439189 0.794118
69 ALA LEU ASP LEU PHE 0.438776 0.685185
70 GLU GLU ASN LEU LEU ASP PHE VAL ARG PHE 0.437037 0.847458
71 ARG LEU GLN ARG ARG ARG GLU THR GLN VAL 0.436975 0.827586
72 GLU ASN LEU TYR PHE GLN 0.436975 0.775862
73 ARG HIS ARG MLZ VAL LEU ARG ASP ASN TYR 0.436242 0.782609
74 ACE ALA ARG THR GLU VAL TYR NH2 0.435484 0.946429
75 ALA ASN SER ARG VAL GLN ASP SER ILE ILE 0.435484 0.8
76 ARG MET PHE PRO ASN ALA PRO TYR LEU 0.434211 0.701299
77 SER ARG ILE ARG ILE ARG GLY TYR VAL ARG 0.434109 0.885246
78 ALA ASN SER ARG TYR PRO THR SER ILE ILE 0.433566 0.736111
79 PHE ALA GLY LEU ARG GLN ALA VAL THR GLN 0.433333 0.842105
80 ARG ARG ARG GLU THR GLN VAL 0.432432 0.810345
81 PHQ LEU VAL ARG TYR 0.432 0.866667
82 BP4 CYS DAR TYR PEA 0.432 0.8
83 ALA PTR ARG 0.431193 0.774194
84 THR LYS ASN TYR LYS GLN THR SER VAL 0.430769 0.770492
85 LEU GLU LYS ALA ARG GLY SER THR TYR 0.430556 0.885246
86 ARG ILE PRO SER TYR ARG TYR ARG TYR 0.42963 0.689189
87 THR LYS ASN TYR LYS GLN PHE SER VAL 0.428571 0.758065
88 LYS ILE LEU HIS ARG LEU LEU GLN ASP 0.428571 0.777778
89 SER ARG TYR TRP ALA ILE ARG THR ARG 0.428571 0.764706
90 ASP PHE GLN GLU SER ALA ASP SER PHE LEU 0.428571 0.733333
91 GLY TYR GLN ASP TYR GLU PRO GLU ALA 0.427419 0.666667
92 TYR GLN PHE 0.427184 0.696429
93 PRO LEU GLU PSA ARG LEU 0.426471 0.809524
94 ALA ASN SER ARG TRP GLN VAL THR ARG VAL 0.426471 0.761194
95 ARG PRO PRO ILE PHE ILE ARG ARG LEU 0.425532 0.695652
96 LEU GLY GLY ALA LYS GLN ARG GLY ASP VAL 0.425 0.789474
97 ALA VAL TYR ASP GLY ARG GLU HIS THR VAL 0.424658 0.80303
98 GLU GLU GLN GLU GLU TYR 0.424242 0.740741
99 ARG ASP ARG ALA ALA LYS LEU 0.422018 0.785714
100 GLY VAL TYR ASP GLY ARG GLU HIS THR VAL 0.421769 0.80303
101 ARG LEU TYR GLN ASN PRO THR THR TYR ILE 0.421053 0.716216
102 TYR GLY GLY PHE LEU 0.421053 0.775862
103 GLU GLU TYR LEU GLN ALA PHE THR TYR 0.421053 0.775862
104 ASP ARG VAL TYR ILE HIS PRO PHE 0.42029 0.857143
105 ARG ARG ARG TRP HIS ARG TRP ARG LEU 0.419847 0.738462
106 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.41958 0.680556
107 HIS LYS ILE LEU HIS ARG LEU LEU GLN ASP 0.41958 0.765625
108 PHE GLU ASP LEU ARG VAL SER SER PHE 0.419118 0.833333
109 PHE GLU ASP LEU ARG VAL LEU SER PHE 0.419118 0.833333
110 ARG PRO GLY ASN PHE LEU GLN ASN ARG PRO 0.418605 0.824561
111 DTY ILE ARG LEU LPD 0.418605 0.761194
112 GLU GLN TYR LYS PHE TYR SER VAL 0.417323 0.770492
113 ALA ARG LYS LEU ASP 0.416667 0.821429
114 THR GLU ASN LEU TYR PHE GLN SER GLY THR 0.416058 0.774194
115 VAL ARG SER ARG ARG CYS LEU ARG LEU 0.415929 0.766667
116 THR ASN GLU PHE TYR ALA 0.415254 0.7
117 SER GLN ASN TYR 0.415094 0.711864
118 THR PRO TYR ASP ILE ASN GLN MET LEU 0.414966 0.626667
119 ILE LEU GLY LYS PHE LEU HIS ARG LEU 0.414286 0.753846
120 ALA LYS PHE ARG HIS ASP 0.414062 0.746032
121 GLY ALA GLN THR PHE TYR VAL ASP GLY ALA 0.414062 0.766667
122 GLU GLY PRO ARG ASN GLN ASP TRP LEU 0.414013 0.684932
123 SER GLU ASP GLU PHE TYR ASP ALA LEU SER 0.413534 0.79661
124 GLY ASN TYR SER PHE TYR ALA LEU 0.413223 0.725806
125 ACE GLU ASN LEU TYR PHE GLN SER GLY THR 0.412698 0.762712
126 VAL LEU ARG ASP ASP LEU LEU GLU ALA 0.412281 0.854545
127 ASP ALA GLU PHE ARG HIS ASP SER 0.410448 0.758065
128 ARG THR PHE SER PRO THR TYR GLY LEU 0.409396 0.75
129 VAL ARG SER ARG ARG ABA LEU ARG LEU 0.408696 0.766667
130 ILE GLN GLN SER ILE GLU ARG ILE 0.408333 0.779661
131 TYR GLN GLU SER THR ASP PHE THR PHE LEU 0.40708 0.661017
132 ARG ILE ILE PRO ARG HIS LEU GLN LEU 0.405405 0.676056
133 PRO GLU GLY ASP PM3 GLU GLU VAL LEU 0.403101 0.709677
134 ALA PHE ARG ILE PRO LEU THR ARG 0.402778 0.704225
135 ALA ARG THR M3L GLN THR ALA ARG 0.401639 0.705882
136 GLU LEU ASP LYS TYR ALA SER 0.401575 0.827586
137 ALA LEU TYR ASN THR ALA ALA ALA LEU 0.4 0.724138
138 ARG VAL LEU PHE GLU ALA MET 0.4 0.8
Similar Ligands (3D)
Ligand no: 1; Ligand: SER ASP TYR GLN ARG LEU; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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