Receptor
PDB id Resolution Class Description Source Keywords
4IHL 2.2 Å EC: 2.7.11.1 HUMAN 14-3-3 ISOFORM ZETA IN COMPLEX WITH A DIPHOYPHORYLATED PEPTIDE AND COTYLENIN A HOMO SAPIENS 14-3-3 FOLD RAF ALL ALPHA-HELICAL ADAPTER PROTEIN PROTEIINTERACTION PEPTIDE BINDING PROTEIN
Ref.: STABILIZATION OF PHYSICAL RAF/14-3-3 INTERACTION BY COTYLENIN A AS TREATMENT STRATEGY FOR RAS MUTANT CA ACS CHEM.BIOL. V. 8 1869 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
K A:301;
B:301;
 Invalid;
Invalid;
 none;
none;
 submit data
39.098 K [K+]
1F5 B:302;
A:302;
 Valid;
Valid;
 none;
none;
 submit data
622.743 C33 H50 O11 C[C@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4IHL 2.2 Å EC: 2.7.11.1 HUMAN 14-3-3 ISOFORM ZETA IN COMPLEX WITH A DIPHOYPHORYLATED PEPTIDE AND COTYLENIN A HOMO SAPIENS 14-3-3 FOLD RAF ALL ALPHA-HELICAL ADAPTER PROTEIN PROTEIINTERACTION PEPTIDE BINDING PROTEIN
Ref.: STABILIZATION OF PHYSICAL RAF/14-3-3 INTERACTION BY COTYLENIN A AS TREATMENT STRATEGY FOR RAS MUTANT CA ACS CHEM.BIOL. V. 8 1869 2013
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 133 families.
1 4IHL - 1F5 C33 H50 O11 C[C@@H]1[C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 101 families.
1 4IHL - 1F5 C33 H50 O11 C[C@@H]1[C....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 70 families.
1 4IHL - 1F5 C33 H50 O11 C[C@@H]1[C....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 1F5; Similar ligands found: 4
No: Ligand ECFP6 Tc MDL keys Tc
1 1F5 1 1
2 CW1 0.707692 0.931035
3 CX7 0.465517 0.758621
4 0V4 0.40146 0.816667
Similar Ligands (3D)
Ligand no: 1; Ligand: 1F5; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4IHL; Ligand: 1F5; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 4ihl.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 4IHL; Ligand: 1F5; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 4ihl.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
APoc FAQ
Feedback