Receptor
PDB id Resolution Class Description Source Keywords
4HOS 2 Å NON-ENZYME: IMMUNE CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN IFIT5 WITH 5`-TRIPHOS OLIGOURIDINE HOMO SAPIENS TPR RNA BINDING; ANTIVIRAL RNA RNA BINDING PROTEIN-RNA CO
Ref.: STRUCTURAL BASIS FOR VIRAL 5'-PPP-RNA RECOGNITION B IFIT PROTEINS. NATURE V. 494 60 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
NA A:501;
 Part of Protein;
 none;
 submit data
22.99 Na [Na+]
UTP U U U X:1;
 Valid;
 none;
 submit data
1168.39 n/a P(=O)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4HOR 1.86 Å NON-ENZYME: IMMUNE CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN IFIT5 WITH 5`-TRIPHOS OLIGOCYTIDINE HOMO SAPIENS TPR RNA BINDING ANTIVIRAL RNA RNA BINDING PROTEIN-RNA CO
Ref.: STRUCTURAL BASIS FOR VIRAL 5'-PPP-RNA RECOGNITION B IFIT PROTEINS. NATURE V. 494 60 2013
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 225 families.
1 4HOR - CTP C C C C n/a n/a
2 4HOT - ATP A A A n/a n/a
3 4HOS - UTP U U U n/a n/a
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 67 families.
1 4HOR - CTP C C C C n/a n/a
2 4HOT - ATP A A A n/a n/a
3 4HOS - UTP U U U n/a n/a
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 4HOR - CTP C C C C n/a n/a
2 4HOT - ATP A A A n/a n/a
3 4HOS - UTP U U U n/a n/a
4 5UDK ic50 ~ 500 nM ATP A A A n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: UTP U U U ; Similar ligands found: 34
No: Ligand ECFP6 Tc MDL keys Tc
1 UTP U U U 1 1
2 CTP C C C C 0.676768 0.925373
3 UDP UDP 0.576471 0.953125
4 UDP GAL 0.525253 0.925373
5 DUT MG 0.521739 0.895522
6 UA3 0.511905 0.923077
7 U3P 0.511905 0.923077
8 PUP 0.480392 0.869565
9 UPU 0.479167 0.924242
10 UDP 0.456522 0.895522
11 44P 0.455556 0.857143
12 U5P 0.454545 0.909091
13 U 0.454545 0.909091
14 U2P 0.443182 0.880597
15 6MZ C U 0.437037 0.794872
16 G 6MZ C U 0.430657 0.805195
17 UTP 0.427083 0.895522
18 660 0.423077 0.884058
19 URM 0.423077 0.884058
20 U5F 0.42268 0.895522
21 2KH 0.42268 0.869565
22 URI 0.421687 0.818182
23 UNP 0.414141 0.869565
24 UAD 0.411215 0.897059
25 UDX 0.411215 0.897059
26 CSV 0.410714 0.835616
27 CSQ 0.410714 0.835616
28 UPG 0.409524 0.897059
29 GDU 0.409524 0.897059
30 UFM 0.409524 0.897059
31 CJB 0.406977 0.80303
32 Y6W 0.40566 0.847222
33 APU 0.401639 0.813333
34 UDH 0.4 0.8
Similar Ligands (3D)
Ligand no: 1; Ligand: UTP U U U ; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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