Receptor
PDB id Resolution Class Description Source Keywords
4H3P 2.3 Å EC: 2.7.11.24 CRYSTAL STRUCTURE OF HUMAN ERK2 COMPLEXED WITH A MAPK DOCKIN HOMO SAPIENS KINASE DOMAIN SIGNALING LINEAR MOTIF SURFACE MUTATION TR
Ref.: PROTEIN-PEPTIDE COMPLEX CRYSTALLIZATION: A CASE STU ERK2 MITOGEN-ACTIVATED PROTEIN KINASE ACTA CRYSTALLOGR.,SECT.D V. 69 486 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ANP D:401;
A:401;
Valid;
Valid;
none;
none;
submit data
506.196 C10 H17 N6 O12 P3 c1nc(...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4H3P 2.3 Å EC: 2.7.11.24 CRYSTAL STRUCTURE OF HUMAN ERK2 COMPLEXED WITH A MAPK DOCKIN HOMO SAPIENS KINASE DOMAIN SIGNALING LINEAR MOTIF SURFACE MUTATION TR
Ref.: PROTEIN-PEPTIDE COMPLEX CRYSTALLIZATION: A CASE STU ERK2 MITOGEN-ACTIVATED PROTEIN KINASE ACTA CRYSTALLOGR.,SECT.D V. 69 486 2013
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 16 families.
1 4H3P - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 4H3P - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 4H3P - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ANP; Similar ligands found: 358
No: Ligand ECFP6 Tc MDL keys Tc
1 ANP 1 1
2 A2D 0.810811 0.945205
3 B4P 0.802632 0.945205
4 ADP 0.802632 0.972222
5 AP5 0.802632 0.945205
6 BA3 0.789474 0.945205
7 AU1 0.782051 1
8 ATP 0.772152 0.972222
9 AN2 0.769231 0.986111
10 AQP 0.7625 0.972222
11 5FA 0.7625 0.972222
12 M33 0.759494 0.932432
13 MAP 0.752941 0.972973
14 ACP 0.75 0.945946
15 APR 0.740741 0.945205
16 AR6 0.740741 0.945205
17 ACQ 0.73494 0.945946
18 AD9 0.731707 0.945946
19 SAP 0.731707 0.921053
20 AGS 0.731707 0.921053
21 AMP 0.723684 0.944444
22 A 0.723684 0.944444
23 ATF 0.717647 0.933333
24 ADX 0.716049 0.851852
25 CA0 0.716049 0.92
26 50T 0.707317 0.932432
27 PRX 0.698795 0.87013
28 ABM 0.696203 0.893333
29 AMP MG 0.683544 0.868421
30 AP2 0.679012 0.933333
31 A12 0.679012 0.933333
32 APC 0.678571 0.933333
33 TAT 0.674419 0.933333
34 A22 0.674157 0.958904
35 SRA 0.670886 0.894737
36 SRP 0.670455 0.883117
37 5AL 0.666667 0.906667
38 ADQ 0.659341 0.92
39 A1R 0.659341 0.884615
40 ADP MG 0.654762 0.881579
41 3OD 0.648936 0.92
42 BIS 0.648936 0.909091
43 5SV 0.648352 0.82716
44 BEF ADP 0.647059 0.858974
45 ADP BEF 0.647059 0.858974
46 OAD 0.645161 0.92
47 25L 0.642105 0.958904
48 AMO 0.641304 0.907895
49 G5P 0.636364 0.897436
50 DLL 0.634409 0.906667
51 AHX 0.634409 0.897436
52 00A 0.634409 0.860759
53 ANP MG 0.633333 0.921053
54 ADV 0.632184 0.907895
55 ADP PO3 0.632184 0.917808
56 RBY 0.632184 0.907895
57 NB8 0.631579 0.897436
58 25A 0.630435 0.945205
59 8QN 0.630435 0.906667
60 OOB 0.630435 0.906667
61 G3A 0.626263 0.897436
62 ATP MG 0.625 0.881579
63 4AD 0.623656 0.896104
64 PAJ 0.623656 0.8625
65 LAD 0.621053 0.839506
66 1ZZ 0.614583 0.819277
67 TXA 0.614583 0.907895
68 ME8 0.614583 0.819277
69 GTA 0.613861 0.864198
70 3UK 0.610526 0.894737
71 SON 0.604651 0.907895
72 ADP ALF 0.604396 0.848101
73 ALF ADP 0.604396 0.848101
74 WAQ 0.604167 0.860759
75 PR8 0.604167 0.829268
76 4UV 0.6 0.871795
77 GAP 0.6 0.87013
78 FYA 0.597938 0.881579
79 PTJ 0.597938 0.873418
80 ADP VO4 0.597826 0.906667
81 VO4 ADP 0.597826 0.906667
82 UP5 0.596154 0.896104
83 YAP 0.59596 0.871795
84 FA5 0.59596 0.883117
85 PAP 0.595506 0.958333
86 A4P 0.59434 0.823529
87 XAH 0.59 0.841463
88 4UU 0.588235 0.871795
89 AFH 0.588235 0.8625
90 9SN 0.585859 0.85
91 2A5 0.58427 0.894737
92 T5A 0.583333 0.821429
93 NAI 0.580952 0.884615
94 ITT 0.579545 0.917808
95 ATR 0.577778 0.944444
96 OMR 0.575472 0.831325
97 5AS 0.574713 0.781609
98 YLP 0.571429 0.8
99 48N 0.571429 0.873418
100 AP0 0.570093 0.873418
101 4TC 0.570093 0.873418
102 7D3 0.569767 0.881579
103 ADJ 0.568807 0.831325
104 GNP 0.568421 0.922078
105 DAL AMP 0.568421 0.881579
106 NXX 0.566038 0.907895
107 TXD 0.566038 0.884615
108 NAX 0.566038 0.851852
109 4UW 0.566038 0.839506
110 6V0 0.566038 0.873418
111 DND 0.566038 0.907895
112 XYA 0.565789 0.821918
113 ADN 0.565789 0.821918
114 RAB 0.565789 0.821918
115 AOC 0.564706 0.8
116 7D4 0.561798 0.881579
117 ADP BMA 0.561224 0.894737
118 TXE 0.560748 0.884615
119 TYM 0.560748 0.883117
120 YLB 0.555556 0.8
121 YLC 0.555556 0.819277
122 139 0.554545 0.851852
123 5N5 0.551282 0.797297
124 JB6 0.55 0.860759
125 LAQ 0.54717 0.819277
126 MYR AMP 0.544554 0.797619
127 A4D 0.544304 0.797297
128 5CD 0.544304 0.783784
129 7MD 0.542857 0.864198
130 6AD 0.542553 0.886076
131 A2R 0.541667 0.958904
132 UPA 0.541284 0.884615
133 YLA 0.540541 0.8
134 A A 0.54 0.918919
135 COD 0.539823 0.793103
136 BTX 0.539823 0.821429
137 G5A 0.537634 0.781609
138 CNA 0.535714 0.907895
139 AYB 0.535714 0.790698
140 3DH 0.535714 0.753247
141 BT5 0.535088 0.811765
142 ATP A A A 0.533981 0.905405
143 IOT 0.531532 0.811765
144 MTA 0.53012 0.753247
145 3AM 0.529412 0.90411
146 A3P 0.52809 0.944444
147 NAD 0.526316 0.906667
148 PPS 0.526316 0.851852
149 EP4 0.52439 0.734177
150 7D5 0.52381 0.855263
151 AMP DBH 0.52381 0.87013
152 J7C 0.522727 0.75
153 A5A 0.520833 0.809524
154 EAD 0.520661 0.851852
155 TSB 0.520408 0.821429
156 AHZ 0.518519 0.797619
157 M2T 0.518072 0.716049
158 DTA 0.518072 0.766234
159 A3D 0.517241 0.894737
160 6RE 0.517241 0.740741
161 YLY 0.516949 0.790698
162 SSA 0.515464 0.802326
163 NA7 0.514852 0.933333
164 TYR AMP 0.514286 0.858974
165 AR6 AR6 0.514019 0.893333
166 7MC 0.513514 0.843373
167 A2P 0.511111 0.930556
168 52H 0.510204 0.781609
169 VMS 0.510204 0.790698
170 54H 0.510204 0.790698
171 TAD 0.509259 0.8625
172 NAQ 0.508333 0.85
173 A3N 0.505618 0.766234
174 AV2 0.505155 0.893333
175 5CA 0.50505 0.802326
176 53H 0.50505 0.781609
177 ARU 0.504951 0.839506
178 ARG AMP 0.504587 0.809524
179 ZID 0.504132 0.894737
180 P1H 0.504 0.831325
181 3AT 0.5 0.945205
182 NAE 0.5 0.871795
183 AVV 0.5 0.873418
184 P5A 0.495146 0.747253
185 DSZ 0.49505 0.802326
186 LSS 0.49505 0.764045
187 NSS 0.49505 0.802326
188 N0B 0.491803 0.8
189 AF3 ADP 3PG 0.491071 0.817073
190 LA8 ALF 3PG 0.491071 0.817073
191 ALF ADP 3PG 0.491071 0.817073
192 NVA LMS 0.490196 0.764045
193 DAT 0.489362 0.881579
194 IMO 0.488889 0.90411
195 ZAS 0.488636 0.792208
196 FDA 0.488372 0.813953
197 NAJ PZO 0.487395 0.85
198 4TA 0.487179 0.788235
199 LPA AMP 0.486486 0.797619
200 LEU LMS 0.485437 0.764045
201 DTP 0.484536 0.881579
202 V3L 0.484536 0.945205
203 GJV 0.483516 0.731707
204 S4M 0.483516 0.651685
205 DZD 0.483051 0.8625
206 2AM 0.482759 0.917808
207 5AD 0.481013 0.726027
208 KAA 0.480769 0.755556
209 GSU 0.480769 0.781609
210 NDE 0.480315 0.907895
211 M24 0.479339 0.851852
212 MAO 0.478261 0.761905
213 DSH 0.477778 0.707317
214 NEC 0.477778 0.727273
215 FAD 0.477273 0.831325
216 FAS 0.477273 0.831325
217 RGT 0.476636 0.933333
218 0WD 0.474576 0.897436
219 G A A A 0.474576 0.85
220 FNK 0.474074 0.786517
221 5X8 0.473684 0.74359
222 6FA 0.473282 0.821429
223 FB0 0.472868 0.786517
224 NDC 0.472868 0.85
225 YSA 0.472222 0.781609
226 7DD 0.468085 0.958333
227 OVE 0.466667 0.881579
228 NAD IBO 0.466102 0.848101
229 MHZ 0.463158 0.701149
230 A3G 0.461538 0.779221
231 6C6 0.459184 0.858974
232 U A G G 0.458333 0.860759
233 SFG 0.458333 0.730769
234 7D7 0.45679 0.723684
235 128 0.45614 0.8
236 SFD 0.455224 0.736842
237 DDS 0.454545 0.855263
238 GDP 0.454545 0.896104
239 6IA 0.454545 0.817073
240 NJP 0.453782 0.921053
241 ODP 0.453782 0.886076
242 7DT 0.453608 0.958333
243 A7D 0.452632 0.75641
244 Z5A 0.452381 0.802326
245 WSA 0.452174 0.790698
246 7C5 0.45045 0.797468
247 FAY 0.449275 0.841463
248 NDP 0.449153 0.897436
249 A5D 0.44898 0.766234
250 SA8 0.44898 0.690476
251 NAJ PYZ 0.448 0.851852
252 71V 0.446809 0.884615
253 GGZ 0.446602 0.804878
254 RFL 0.446043 0.802326
255 2SA 0.445545 0.907895
256 AMP NAD 0.444444 0.858974
257 GP3 0.444444 0.897436
258 SAI 0.444444 0.716049
259 SAH 0.444444 0.725
260 A A A 0.443396 0.881579
261 PO4 PO4 A A A A PO4 0.443396 0.878378
262 4YB 0.442478 0.764045
263 GTP 0.441176 0.896104
264 SMM 0.441176 0.670455
265 S7M 0.441176 0.674419
266 Y3J 0.440476 0.706667
267 SAM 0.44 0.674419
268 649 0.439655 0.747253
269 12D 0.438596 0.809524
270 A3S 0.4375 0.789474
271 NPW 0.436975 0.864198
272 GCP 0.436893 0.873418
273 AAT 0.435644 0.690476
274 EEM 0.435644 0.674419
275 GNH 0.435644 0.909091
276 DCA 0.435484 0.804598
277 ETB 0.435484 0.813953
278 N6P 0.433962 0.890411
279 TXP 0.433333 0.897436
280 NZQ 0.433333 0.886076
281 PGS 0.43299 0.860759
282 APU 0.432203 0.871795
283 PUA 0.432 0.8625
284 62F 0.431655 0.841463
285 F2N 0.431507 0.795455
286 DA 0.430108 0.855263
287 D5M 0.430108 0.855263
288 J7V 0.429688 0.813953
289 NIA 0.428571 0.848101
290 6K6 0.428571 0.905405
291 A3T 0.428571 0.8
292 0T1 0.428571 0.804598
293 COA 0.428571 0.804598
294 P5F 0.427586 0.804598
295 AAM 0.425532 0.944444
296 0UM 0.424528 0.682353
297 G1R 0.423077 0.884615
298 AMZ 0.422222 0.891892
299 C2R 0.422222 0.88
300 A U 0.420168 0.848101
301 IDP 0.42 0.894737
302 GSP 0.419048 0.851852
303 COS 0.418605 0.786517
304 CAO 0.418605 0.777778
305 AMX 0.418605 0.813953
306 30N 0.418605 0.736842
307 DG1 0.418605 0.897436
308 1DG 0.418605 0.897436
309 TM1 0.418182 0.797619
310 A6D 0.416667 0.746988
311 K15 0.416667 0.666667
312 V1N 0.415929 0.893333
313 SCO 0.415385 0.804598
314 CMX 0.415385 0.804598
315 GEK 0.415094 0.719512
316 NHD 0.414634 0.881579
317 XNP 0.414634 0.851852
318 AIR 0.413793 0.876712
319 COK 0.413534 0.786517
320 G2R 0.412844 0.8625
321 FCX 0.412214 0.777778
322 FAM 0.412214 0.786517
323 ACO 0.412214 0.777778
324 NAP 0.410853 0.92
325 CNV FAD 0.409722 0.775281
326 FA9 0.409396 0.843373
327 SXZ 0.409091 0.694118
328 HAX 0.409091 0.806818
329 PLP AAD 0.408 0.744444
330 TAP 0.407692 0.884615
331 2MC 0.407407 0.752688
332 62X 0.407407 0.651685
333 GKE 0.40708 0.8625
334 GDD 0.40708 0.8625
335 GDC 0.40708 0.8625
336 FYN 0.406015 0.804598
337 3KK 0.406015 0.786517
338 U G A 0.405797 0.819277
339 NA0 0.40458 0.907895
340 101 0.404255 0.855263
341 G 0.40404 0.883117
342 5GP 0.40404 0.883117
343 MGP 0.403846 0.8625
344 MCD 0.402985 0.786517
345 OXK 0.402985 0.786517
346 CA6 0.402985 0.714286
347 SOP 0.402985 0.786517
348 3AD 0.402299 0.783784
349 S8M 0.401869 0.78481
350 YE1 0.40146 0.795455
351 1VU 0.4 0.777778
352 2VA 0.4 0.779221
353 CMC 0.4 0.786517
354 7RP 0.4 0.902778
355 GMV 0.4 0.873418
356 6G0 0.4 0.8625
357 CO6 0.4 0.786517
358 NMX 0.4 0.782609
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4H3P; Ligand: ANP; Similar sites found: 353
This union binding pocket(no: 1) in the query (biounit: 4h3p.bio1) has 20 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3AKK ADP 0.0007554 0.44607 1.53846
2 2QK4 ATP 0.0009339 0.41148 1.65746
3 3DNT ATP 0.008032 0.4079 1.65746
4 1ME8 RVP 0.01943 0.40529 1.65746
5 3BP1 GUN 0.00848 0.4368 1.72414
6 5T96 79J 0.01903 0.40061 1.75439
7 2IF8 ADP 0.001635 0.45879 1.92837
8 4GYI ADP 0.0002042 0.48492 1.9337
9 3K5I ADP 0.003362 0.40506 1.9337
10 2ZL7 FUC GAL NGA 0.006906 0.42929 2.0339
11 5TDF ADP 0.005624 0.40967 2.16049
12 5I35 ANP 0.0000008502 0.56414 2.20994
13 1E4E ADP 0.005654 0.40085 2.33236
14 1S9D AFB 0.01458 0.40207 2.46305
15 3VPB ADP 0.00005273 0.45141 2.48227
16 3VPC ADP 0.0003509 0.43857 2.48227
17 5GZ9 ANP 0.00000008606 0.62815 2.48619
18 2VPQ ANP 0.0001333 0.48579 2.48619
19 5VZ0 ADP 0.0002475 0.45921 2.48619
20 3TII ANP 0.001954 0.40791 2.48619
21 2R7K AMZ 0.01148 0.40667 2.49307
22 1I7L ATP 0.00008359 0.44802 2.589
23 5W2I ADP 0.002281 0.43248 2.72374
24 5W2I I3P 0.002281 0.43248 2.72374
25 2PUL ACP 0.00002202 0.51686 2.76243
26 1F52 ADP 0.009751 0.40637 2.76243
27 4ZS4 ATP 0.000006949 0.52263 2.9316
28 1CKN GTP 0.01368 0.4076 3.0303
29 5MW8 ATP 0.000005923 0.54614 3.03867
30 4OCV ANP 0.0005607 0.44341 3.03867
31 2HGS ADP 0.003207 0.42412 3.03867
32 1M0W ANP 0.004098 0.40408 3.03867
33 5L2J 6UL 0.03826 0.40913 3.06122
34 4FE2 ADP 0.005634 0.41754 3.13725
35 3D91 REM 0.01475 0.42881 3.22581
36 1IOW ADP 0.001778 0.45072 3.26797
37 1IOW PHY 0.001778 0.45072 3.26797
38 3PDT ADP 0.00002331 0.52217 3.27273
39 1EHI ADP 0.0009097 0.43384 3.31492
40 3LVW GSH 0.0104 0.4171 3.31492
41 4MV1 ADP 0.009279 0.4148 3.31492
42 4LH7 1X8 0.001668 0.46051 3.40557
43 2VQD AP2 0.0000986 0.46698 3.59116
44 5MRH Q9Z 0.001419 0.45609 3.59116
45 1F1V DHY 0.01828 0.40136 3.71517
46 2Q7D ANP 0.002838 0.43148 3.75723
47 3HW5 AMP 0.02407 0.4017 3.83142
48 4LRJ ANP 0.000001716 0.56626 3.8674
49 4CC6 L5Y 0.00215 0.40114 3.8674
50 1ZTH ADP 0.000003681 0.57453 3.87597
51 1ZP9 ATP 0.00001182 0.53562 3.87597
52 3RE4 TO1 0.00003647 0.52683 3.87597
53 3W0O ADP 0.0002796 0.40255 4.01146
54 3W0O HY0 0.0002796 0.40255 4.01146
55 4CT7 TRP 0.01811 0.40923 4.07407
56 1GSA ADP 0.00009892 0.49157 4.11392
57 4U98 ACP 0.0007133 0.44953 4.14365
58 3ETH ATP 0.0004973 0.43192 4.22535
59 4XMF HSM 0.0000235 0.5829 4.34783
60 3V4S ATP 0.001452 0.41418 4.41989
61 3WG3 A2G GAL NAG FUC 0.01388 0.41305 4.49438
62 3ORQ ADP 0.000534 0.43798 4.69613
63 3VOT ADP 0.000864 0.42017 4.69613
64 2YLD CMO 0.01576 0.40766 4.72441
65 5K2M ADP 0.0003963 0.4666 4.7619
66 3VPD ANP 0.0002436 0.47204 4.98221
67 5IQD GNP 0.00003958 0.53083 5.2459
68 5IQD RIO 0.00004249 0.53083 5.2459
69 2IO8 ADP 0.0008419 0.41166 5.24862
70 2WBV SIA 0.03707 0.40299 5.29101
71 4R78 AMP 0.0006435 0.47297 5.50162
72 2CFM AMP 0.0002531 0.48653 5.52486
73 3X01 AMP 0.0008452 0.47682 5.52486
74 1W2D ADP 0.001537 0.449 5.66038
75 4AZT LY2 0.002066 0.44284 5.80111
76 4AZW ATP 0.002081 0.42876 5.80111
77 1OBD ATP 0.004468 0.42226 5.88235
78 5C1P ADP 0.002077 0.42679 6.20915
79 2PYW ADP 0.00004552 0.47931 6.35359
80 2Z49 AMG 0.0131 0.41844 6.35359
81 3HAV ATP 0.0005975 0.40709 6.35452
82 1TQP ATP 0.00002184 0.46947 6.38298
83 4B1L FRU 0.01341 0.41519 6.66667
84 3OYW TDG 0.01758 0.40654 6.71642
85 1Q8S MAN MMA 0.01797 0.40842 6.74603
86 2UYN 2KT 0.01053 0.4143 6.97674
87 3I0O ADP 0.00006192 0.51582 7.37463
88 4CS9 AMP 0.023 0.40052 7.40741
89 5C4L 4XR 0.00004538 0.52016 7.47664
90 5C4L SIS 0.0001709 0.49361 7.47664
91 1IA9 ANP 0.00004469 0.48922 7.5
92 2OVD DAO 0.01429 0.41366 7.69231
93 5AIG VPR 0.01723 0.40263 8
94 4O4F IHP 0.001524 0.44373 8.06452
95 4O4F ATP 0.001401 0.44373 8.06452
96 4OUC 5ID 0.000005447 0.52508 8.12325
97 4GLW 0XT 0.00822 0.41852 8.19672
98 3ZGJ RMN 0.01196 0.41504 8.28729
99 3LQV ADE 0.01748 0.41102 8.69565
100 3TDV GDP 0.0000643 0.49047 8.82353
101 4O1P ANP 0.000000001999 0.68689 8.83978
102 5LXT ACP 0.0009266 0.41514 8.83978
103 4XYM A12 0.001055 0.4397 9.56522
104 3UDZ ADP 0.000002028 0.55883 9.66851
105 4AXD ANP 0.00001155 0.41668 9.66851
106 5T7I LAT NAG GAL 0.01249 0.41662 10.3226
107 4WW7 AMP 0.000002202 0.56275 10.3448
108 1PK8 ATP 0.00007008 0.44511 10.4972
109 5A5W GUO 0.001674 0.45904 10.6719
110 2BKK ADP 0.0006783 0.43219 11.2426
111 1AUX AGS 0.00004454 0.49742 11.8971
112 3WVR AMP 0.001044 0.44684 12.5
113 4IAW LIZ 0.01493 0.40572 12.766
114 5C03 AGS 0.0000001098 0.61107 12.8655
115 2GJ5 VD3 0.02202 0.4027 12.963
116 5CKW ANP 0.00005917 0.46982 13.2597
117 4IX4 ADP 0.00001765 0.52018 13.4286
118 4WOV 3SM 0.0000004147 0.6107 13.8801
119 5USZ SKE 0.00000002179 0.66584 14.1869
120 4OAV ACP 0.000000004942 0.67949 14.6409
121 3ZJX BOG 0.001252 0.46837 14.8789
122 4OH4 ANP 0.000000001395 0.6937 15.6156
123 5LPZ ADP 0.0000000000713 0.74998 15.9639
124 5DMZ ADP 0.000003032 0.54827 16.6667
125 1KC7 PPR 0.01329 0.41031 16.8508
126 3RI1 3RH 0.0000000958 0.53664 17.5719
127 3E8N VRA 0.000000006861 0.46546 17.5953
128 3E8N ATP 0.000000006861 0.46546 17.5953
129 2X2M X2M 0.0000001425 0.56706 17.8344
130 4XH0 ADP 0.0000001722 0.66806 18.232
131 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.00000002633 0.70761 19.0058
132 2JDR L20 0.00000002633 0.70761 19.0058
133 4L9I 8PR 0.000001645 0.55282 19.0476
134 3GNI ATP 0.00000000136 0.6596 19.6133
135 4I94 ANP 0.0000005295 0.58901 19.6667
136 4FL3 ANP 0.0000000005006 0.66182 20.1657
137 5W4W 9WG 0.000001037 0.59581 21.4502
138 4KBA 1QM 0.00001295 0.45747 21.4502
139 4Q5H ANP 0.000008758 0.5282 21.7949
140 3VHE 42Q 0.000001458 0.4708 22.5627
141 4G17 0VN 0.00002422 0.49594 23.0303
142 5VC5 96M 0.000000006849 0.68872 24.2215
143 2CSN CKI 0.0000000001409 0.62782 24.2424
144 5M06 ADP 0.0000006844 0.55707 24.2754
145 4BTK DTQ 0.000001361 0.56343 24.5856
146 4NFN 2KC 0.00001586 0.52321 24.5856
147 5KO1 6UY 0.000000006368 0.65217 24.735
148 3FHR P4O 0.000009003 0.51726 25.2976
149 3PP0 03Q 0.000001432 0.49311 25.4438
150 2F2U M77 0.0000003798 0.62177 25.6906
151 4E93 GUI 0.000000004224 0.53097 25.6906
152 4WNK 453 0.00000006171 0.65004 26.5193
153 3DLS ADP 0.000001382 0.5465 26.5672
154 5HCY 60D 0.000000002316 0.74154 26.5861
155 4U44 3D9 0.000002585 0.5513 26.8072
156 4CLI 5P8 0.00000002018 0.69655 26.9113
157 4WB7 ATP 0.0000004395 0.46311 27.0718
158 4IDT T28 0.00000005968 0.63127 27.2472
159 3V8S 0HD 0.00000003435 0.62197 27.3171
160 4UAL 3FV 0.00000008336 0.61629 27.6243
161 1OPK P16 0.0000547 0.41732 27.6243
162 3UIM ANP 0.000000002846 0.6802 27.9141
163 3LXN MI1 0.00000001175 0.62424 27.9874
164 3KMW ATP 0.00004185 0.50443 28.0443
165 3MVH WFE 0.000000001684 0.72185 28.0702
166 3VRY B43 0.0000001604 0.52937 28.1768
167 5AX9 4KT 0.000000487 0.58288 28.2468
168 2QCS ANP 0.00000002684 0.65913 28.2857
169 5T8O 76Z 0.0000003432 0.5648 28.3668
170 1RE8 BD2 0.00000002687 0.69391 28.5714
171 3FHI ANP 0.00000004385 0.64947 28.5714
172 4WB6 ATP 0.00000006108 0.64295 28.5714
173 3IDB ANP 0.00000005137 0.57582 28.5714
174 4Y93 746 0.000000266 0.61153 28.7293
175 1Y57 MPZ 0.000000007312 0.60653 28.7293
176 2H8H H8H 0.0000001776 0.60198 28.7293
177 4Y0X ADP 0.000001854 0.542 28.7293
178 4P5Z Q7M 0.0000001993 0.64056 28.8089
179 3TXO 07U 0.000000543 0.56339 28.8952
180 3Q60 ATP 0.000001757 0.55012 29.1667
181 2GQR ADP 0.003029 0.41274 29.1667
182 3PN1 IVH 0.0009966 0.40842 29.1667
183 4ASE AV9 0.00000286 0.56944 29.1785
184 4Y85 499 0.000008867 0.52109 29.2169
185 5LVP ATP 0.000000002556 0.64591 29.2605
186 4X7Q 3YR 0.0000005544 0.58043 29.4872
187 3KRL KRL 0.000001556 0.52582 29.5522
188 4N70 2HX 0.000000004715 0.73364 29.5732
189 3SLS ANP 0.000000001235 0.64674 29.6053
190 2OO8 RAJ 0.001757 0.40814 29.653
191 2GU8 796 0.00000001745 0.71502 29.6736
192 4GJ3 0XP 0.00000007992 0.64713 29.8013
193 5DBX ANP 0.00000002201 0.60427 29.878
194 5VCV 1N1 0.000000007276 0.59028 29.9035
195 3ORK AGS 0.0000002016 0.53555 29.9035
196 4Y8D 49J 0.000000773 0.57414 30
197 5UIU 8CG 0.00000001791 0.6747 30.031
198 3H9R TAK 0.000001009 0.6108 30.1105
199 3QCQ 3Q0 0.0000001264 0.69927 30.1282
200 5U6C 7YS 0.00000003277 0.64385 30.1587
201 5JGA 6KC 0.0000001378 0.4868 30.1587
202 2PVF ACP 0.000000002161 0.6955 30.2395
203 2QLU ADE 0.000002064 0.61658 30.2548
204 5HVJ ANP 0.0000001 0.67776 30.4762
205 4BKJ STI 0.0002503 0.47746 30.4762
206 4E1Z 0MX 0.00000008568 0.56502 30.5842
207 3CY2 MB9 0.00000004808 0.5747 30.8917
208 4QMN DB8 0.00000002477 0.67926 30.9677
209 4OTH DRN 0.000000001718 0.70068 31.085
210 5CEO 50D 0.0000004198 0.58569 31.3333
211 2XVD AS6 0.00000001934 0.67073 31.457
212 3GGF GVD 0.00000008143 0.63423 31.5615
213 3SXS PP2 0.000001451 0.53783 31.7164
214 5LPB ADP 0.000000005906 0.61642 31.7568
215 3C1X CKK 0.000009081 0.49624 31.768
216 4AT3 LTI 0.000001211 0.47199 31.7726
217 3LXK MI1 0.0000001534 0.52164 31.8043
218 4YMJ 4EJ 0.0000000444 0.69687 31.9079
219 3NW7 LGV 0.0000008149 0.62262 31.9218
220 5HES 032 0.000005257 0.54598 31.9218
221 1JPA ANP 0.00000001001 0.44602 32.0513
222 2Z7R STU 0.0000000001971 0.67864 32.0872
223 4U0I 0LI 0.00007558 0.50995 32.381
224 1K3A ACP 0.00000000323 0.6402 32.4415
225 5HX8 66P 0.00000002217 0.55749 32.4503
226 5MJA 7O3 0.0000003712 0.56562 32.459
227 4AG8 AXI 0.000006288 0.42467 32.5949
228 4YZN 4K5 0.000000002334 0.69807 32.7526
229 1U59 STU 0.0000003144 0.59116 32.7526
230 5JFS 6K0 0.0000000329 0.68115 32.7922
231 5JKG 6LF 0.000006433 0.56947 32.7974
232 3PLS ANP 0.00000000002412 0.75573 32.8859
233 4K33 ACP 0.00000001195 0.63821 32.9231
234 3BU5 ATP 0.000000001028 0.69947 33.3333
235 4CYI ATP 0.000007664 0.53617 33.3333
236 2PZI AXX 0.00008531 0.50262 33.3333
237 2YW2 ATP 0.003922 0.40117 33.3333
238 4FF8 14S 0.0001203 0.45188 33.4365
239 4M69 ANP 0.000000003008 0.68647 33.5463
240 4TWP AXI 0.000001642 0.60657 33.5793
241 3GQI ACP 0.000000002603 0.68189 33.7423
242 4G31 0WH 0.00001446 0.41772 33.7793
243 3EKK GS2 0.000000002772 0.50893 33.8762
244 3SRV S19 0.000000006165 0.65422 33.935
245 4XLI 1N1 0.00000566 0.54315 33.9552
246 5NKB 8ZT 0.00000004597 0.45196 33.9869
247 2A19 ANP 0.000000001455 0.73751 34.1549
248 1VJY 460 0.00000001273 0.68623 34.3234
249 4F4P 0SB 0.0000006242 0.64234 34.4322
250 1BYG STU 0.00000001693 0.62506 34.5324
251 4EWH T77 0.0000003632 0.50875 34.5455
252 2Y6O 1N1 0.0000003061 0.55095 34.7079
253 5DRB 5FJ 0.000001986 0.40861 34.7079
254 5TO8 7FM 0.0000003045 0.63362 34.7518
255 3DAK ANP 0.000000005028 0.6894 34.8276
256 4CSV STI 0.00009397 0.49257 34.9091
257 3AQV TAK 0.000699 0.44531 35.1449
258 5UR1 YY9 0.0000003033 0.63866 35.6913
259 4XV1 904 0.00000001619 0.68363 35.9589
260 5EOB 5QQ 0.00000008979 0.67878 36.0502
261 4YZC STU 0.00000001533 0.69106 36.1878
262 3G5D 1N1 0.00000006108 0.68832 36.3636
263 5N87 N66 0.0000000003942 0.76341 36.4641
264 5FBN 5WF 0.0000001709 0.63807 36.5314
265 2YAB AMP 0.00000006084 0.62563 36.5651
266 2WQN ADP 0.0000001659 0.62929 36.7742
267 3SXF BK5 0.0000004944 0.46133 37.0166
268 2OFV 242 0.0000004098 0.62223 37.1841
269 3HZT J60 0.000004075 0.57241 37.2928
270 2RIO ADP 0.000000007468 0.6715 37.5
271 5LI1 ANP 0.0000000329 0.64377 37.5
272 5LI9 ACP 0.00000036 0.57587 37.5
273 4BHN BH9 0.0000009841 0.57551 37.5
274 4DC2 ADE 0.0000001868 0.49761 37.5
275 3C0G 3AM 0.0000000521 0.59263 37.6068
276 5DEY 59T 0.0000003086 0.65124 37.7104
277 4CQE CQE 0.00000371 0.51129 37.7698
278 4BFM ANP 0.000000003269 0.64619 38.024
279 2HK5 1BM 0.00000009366 0.62058 38.1481
280 5TA6 79D 0.0000001131 0.52415 38.2682
281 3HMO STU 0.000000006892 0.67305 38.3041
282 3TKI S25 0.0000000739 0.68156 38.3901
283 1Q8Y ADE 0.00000008064 0.66473 38.3978
284 1Q8Y ADP 0.00000001347 0.62187 38.3978
285 2HY0 306 0.00001604 0.53653 38.5093
286 4JDI ANP 0.000000005341 0.63674 38.7283
287 4A4X JUP 0.00000003982 0.65137 39.0681
288 5MY8 RXZ 0.00000008448 0.63399 39.2265
289 5H2U 1N1 0.0000008295 0.5728 39.3258
290 1PHK ATP 0.00000000004881 0.76139 39.5973
291 5DA3 58V 0.00000001002 0.69739 39.6226
292 5IH9 6BF 0.00000006164 0.66073 39.7015
293 2J7T 274 0.00006052 0.42212 39.7351
294 5UOX 8GY 0.000001002 0.57793 39.8524
295 1ZY5 ANP 0.000002821 0.55664 39.934
296 3M2W L8I 0.00000009796 0.63998 40.1338
297 5DH3 5BS 0.000001928 0.56262 40.3175
298 2WU6 DKI 0.0000000001175 0.67126 40.6077
299 3ALN ANP 0.000000001626 0.65778 40.9786
300 1XJD STU 0.0000001807 0.58886 41.1594
301 2R5T ANP 0.00000005475 0.58629 41.1602
302 4NW6 2NS 0.00000001259 0.52113 41.1765
303 2F57 23D 0.0000003749 0.60399 41.3249
304 3FC2 IBI 0.00001158 0.5864 41.4925
305 4F9C 0SX 0.0000000225 0.65015 41.5512
306 3KRR DQX 0.00000005388 0.69978 41.6667
307 5UKL SIX 0.000001102 0.58828 41.6667
308 4EUU BX7 0.00000004956 0.54282 41.6667
309 3PVW QRX 0.0000003646 0.5165 41.6667
310 3IGO ANP 0.0000000719 0.5792 41.7127
311 2V7O DRN 0.00000000867 0.59662 41.9643
312 5A6N U7E 0.00000000451 0.67519 42.0495
313 4JR7 GNP 0.00000009227 0.61437 42.246
314 1U5R ATP 0.0000000002577 0.73666 42.2652
315 3KN5 ANP 0.00000006685 0.59147 42.7692
316 5X8I SQZ 0.000000001466 0.69276 42.7746
317 2WEL K88 0.00000008825 0.53047 42.8135
318 4USF 6UI 0.0000473 0.50802 43.0921
319 4YLL 4E3 0.000000001623 0.70511 43.2133
320 2XK9 XK9 0.000000009046 0.69973 43.4783
321 4FG8 ATP 0.00000006187 0.59604 43.8095
322 4I6H 1C8 0.000001854 0.55759 43.8312
323 4CRL C1I 0.00000002508 0.6748 44.1989
324 5JZJ AN2 0.00000000197 0.67547 44.4444
325 5EYK 5U5 0.0000007402 0.59616 44.5652
326 4IJP 1EH 0.000000004814 0.67746 44.6927
327 2VZ6 FEF 0.0000008287 0.59665 44.7284
328 5LXC 7AA 0.000000007677 0.63783 44.7514
329 5EW9 5VC 0.000002707 0.64029 45.0185
330 4D2S DYK 0.0000001259 0.57395 45.0704
331 2X4Z X4Z 0.0000002859 0.62765 45.2703
332 3PE2 E1B 0.00000002727 0.69361 45.4006
333 2PVN P63 0.00000001718 0.54278 45.4545
334 4C2W ANP 0.00000001159 0.6052 45.5197
335 5L8L ADP 0.00000000592 0.61751 45.614
336 5G1X ADP 0.00000006155 0.61238 45.614
337 4NST ADP 0.0000000002874 0.7236 45.8689
338 3E5A VX6 0.000001227 0.50595 45.8955
339 5LXM ADP 0.00000006903 0.61079 45.9364
340 2VN9 GVD 0.00000007444 0.66644 46.5116
341 4WNP 3RJ 0.00000002234 0.66997 46.6899
342 5EFQ ADP 0.00000000006693 0.75117 46.9741
343 2YAK OSV 0.0000000004756 0.57806 47.3684
344 3OFM 4B0 0.0000002293 0.56521 47.7143
345 4C2V YJA 0.000009481 0.45233 47.7273
346 3F7Z 34O 0.00000007728 0.61772 47.7901
347 3ZRM ZRM 0.000003421 0.54599 47.7901
348 4KS7 X4Z 0.00000005049 0.57475 47.9452
349 3GC0 AMP 0.0000001755 0.57218 48.0243
350 1O9U ADZ 0.0000006349 0.65002 48.0663
351 2JLD AG1 0.000000001419 0.54143 48.0663
352 4NM5 ADP 0.0005307 0.49128 48.0663
353 2ZV2 609 0.000001353 0.59535 48.3221
Pocket No.: 2; Query (leader) PDB : 4H3P; Ligand: ANP; Similar sites found: 6
This union binding pocket(no: 2) in the query (biounit: 4h3p.bio2) has 20 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4FFG 0U8 0.02111 0.4048 2.20994
2 1DQX BMP 0.008875 0.40265 2.62172
3 1XE7 GUN 0.01425 0.41417 3.44828
4 1Q8Q MAN MMA 0.01573 0.41079 6.74603
5 1KR3 113 0.02249 0.40108 8.18966
6 3NGU ADP 0.02435 0.40092 23.8411
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