Receptor
PDB id Resolution Class Description Source Keywords
4GV1 1.49 Å EC: 2.7.11.1 PKB ALPHA IN COMPLEX WITH AZD5363 HOMO SAPIENS PROTEIN KINASE TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: DISCOVERY OF 4-AMINO-N-[(1S)-1-(4-CHLOROPHENYL)-3-HYDROXYPROPYL] PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDINE-4-CARBOXAMI (AZD5363), AN ORALLY BIOAVAILABLE, POTENT INHIBITOR KINASES. J.MED.CHEM. V. 56 2059 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GOL A:503;
A:502;
A:505;
A:504;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
0XZ A:501;
Valid;
none;
ic50 = 3 nM
428.915 C21 H25 Cl N6 O2 c1cc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3MVH 2.01 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF AKT-1-INHIBITOR COMPLEXES HOMO SAPIENS KINASE INHIBITOR TRANSFERASE
Ref.: DESIGN OF SELECTIVE, ATP-COMPETITIVE INHIBITORS OF J.MED.CHEM. V. 53 4615 2010
Members (9)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 129 families.
1 3QKK - SMH C28 H38 N2 O7 S CCOCCN(CC(....
2 4EKL ic50 = 5 nM 0RF C24 H32 Cl N5 O2 CC1CC(c2c1....
3 3CQW ic50 = 42 nM CQW C12 H11 Cl N6 c1c(c2c([n....
4 3MV5 ic50 = 180 nM XFE C11 H15 N5 Cc1c[nH]c2....
5 3QKL - SMR C29 H40 N4 O5 S CCOCCN(CC(....
6 4GV1 ic50 = 3 nM 0XZ C21 H25 Cl N6 O2 c1cc(ccc1C....
7 3QKM ic50 = 0.038 uM SM9 C31 H43 N5 O4 S CCOCCN(CC(....
8 3MVH ic50 = 0.5 nM WFE C20 H22 F2 N6 O CCc1c[nH]c....
9 3CQU ic50 = 151 nM CQU C15 H13 N7 Cc1[nH]c(n....
70% Homology Family (18)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 94 families.
1 1O6L - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
2 2UW9 - GVP C20 H20 Cl N3 c1cc(ccc1c....
3 2JDR ic50 = 0.5 nM L20 C24 H23 N5 O Cc1c2cc(cc....
4 3D0E ic50 = 13 nM G93 C21 H27 N7 O3 CCn1c2c(cn....
5 2JDO ic50 = 0.23 uM I5S C20 H22 Cl N3 O3 S c1cc2cnccc....
6 2X39 ic50 = 30 nM X39 C19 H21 Cl N6 O c1cc(ccc1C....
7 3E87 - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
8 1O6K - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
9 3E88 Ki = 2 nM G96 C24 H27 N7 O3 CCn1c2cc(n....
10 3QKK - SMH C28 H38 N2 O7 S CCOCCN(CC(....
11 4EKL ic50 = 5 nM 0RF C24 H32 Cl N5 O2 CC1CC(c2c1....
12 3CQW ic50 = 42 nM CQW C12 H11 Cl N6 c1c(c2c([n....
13 3MV5 ic50 = 180 nM XFE C11 H15 N5 Cc1c[nH]c2....
14 3QKL - SMR C29 H40 N4 O5 S CCOCCN(CC(....
15 4GV1 ic50 = 3 nM 0XZ C21 H25 Cl N6 O2 c1cc(ccc1C....
16 3QKM ic50 = 0.038 uM SM9 C31 H43 N5 O4 S CCOCCN(CC(....
17 3MVH ic50 = 0.5 nM WFE C20 H22 F2 N6 O CCc1c[nH]c....
18 3CQU ic50 = 151 nM CQU C15 H13 N7 Cc1[nH]c(n....
50% Homology Family (385)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 68 families.
1 3UOD Kd = 49 nM 0C3 C18 H13 F3 N4 O2 c1ccc(c(c1....
2 4UZH ic50 = 9800 nM JVE C15 H13 F N4 O c1ccc(c(c1....
3 3EFW - AK8 C25 H21 F3 N6 O2 Cc1cc(ccc1....
4 3UO4 Kd = 299 nM 0C0 C23 H18 N4 O2 c1ccc(cc1)....
5 3UP2 Kd = 40 nM 0C8 C18 H13 F3 N4 O3 c1ccc(c(c1....
6 2C6E - HPM C28 H31 N7 O4 COc1cc2c(c....
7 3H0Y ic50 = 0.006 uM 48B C23 H17 Cl F N5 O2 c1ccc(c(c1....
8 4B0G ic50 = 0.015 uM VEK C19 H21 Br N8 O Cc1cc(no1)....
9 4JBP ic50 = 41 nM YPH C34 H36 N6 O4 c1ccc(cc1)....
10 3H10 - 97B C30 H25 Cl F2 N6 O CN1CCN(CC1....
11 3DJ5 - AK5 C21 H20 Br N5 O3 S COc1ccc(cc....
12 3UOL ic50 = 3.1 nM 0C7 C17 H13 Cl N8 c1ccc(c(c1....
13 3D14 ic50 = 22 nM AK1 C19 H15 F3 N6 O S2 c1cc(cc(c1....
14 1MQ4 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
15 4BN1 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
16 2NP8 ic50 = 42 nM CC3 C21 H18 F3 N5 O c1cc(cc(c1....
17 4JBQ - VX6 C23 H28 N8 O S Cc1cc([nH]....
18 3DJ6 - AK6 C25 H24 N4 O3 S COc1ccc(cc....
19 2WQE - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
20 4UYN ic50 = 2 nM Y3M C25 H22 N4 O4 S CCOC(=O)c1....
21 2WTV Ki = 1.8 nM ZZL C25 H15 Cl F2 N4 O2 c1cc(c(c(c....
22 3FDN ic50 = 0.033 uM MMH C21 H22 N6 O3 Cc1c(c([nH....
23 4J8M ic50 = 48 nM CJ5 C26 H25 F3 N8 O c1cc(cc(c1....
24 3O50 - LJE C24 H17 F3 N4 O2 Cc1cc(ccc1....
25 2J4Z ic50 = 65 nM 626 C23 H24 N6 O2 S CN1CCN(CC1....
26 3LAU ic50 = 0.044 uM OFI C17 H17 N3 O2 CCCC(=O)Nc....
27 4DEA ic50 = 256 nM NHI C18 H14 N4 O4 c1cc(ccc1C....
28 3DAJ ic50 = 2.9 uM FXG C22 H29 N7 O2 CCCCNC(=O)....
29 4JBO ic50 = 24 nM WPH C31 H32 N6 O3 CN(C)CCOc1....
30 2C6D - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
31 4DEE - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
32 3K5U ic50 = 309 nM PFQ C20 H17 N3 O2 c1ccc(cc1)....
33 1JSV - U55 C10 H11 N5 O2 S c1cc(ccc1N....
34 1E1V Ki = 12 uM CMG C12 H17 N5 O c1[nH]c2c(....
35 1OIQ ic50 = 2.9 uM HDU C14 H13 N5 O Cc1c(n2ccc....
36 2VV9 ic50 = 0.017 uM IM9 C23 H29 N7 O2 Cc1ncc(n1C....
37 2W17 ic50 = 0.002 uM I19 C24 H30 F N7 O Cc1ncc(n1C....
38 2VTP ic50 = 0.003 uM LZ9 C17 H11 F3 N4 O2 c1cc(c(c(c....
39 1JVP ic50 = 1.6 uM LIG C15 H11 N3 c1ccc-2c(c....
40 1FVT - 106 C14 H9 Br N4 O3 S c1cc(ccc1N....
41 4KD1 - 1QK C21 H29 N6 O2 CCc1cnn2c1....
42 2BTS ic50 = 20 nM U32 C12 H15 N3 O2 S2 CC(C)c1cnc....
43 3LE6 ic50 = 0.035 uM 2BZ C17 H10 Cl N5 O2 Cc1c-2nc(c....
44 2VTI ic50 = 0.66 uM LZ3 C14 H12 N4 O3 S c1ccc2c(c1....
45 3LFS Ki = 2.5 uM A07 C17 H16 Cl N3 O CCCC(=O)Nc....
46 1PXI - CK1 C8 H5 Cl2 N3 S c1cnc(nc1c....
47 1URW ic50 < 0.003 uM I1P C21 H24 N8 O2 S CN(C)CCCNS....
48 4LYN - 1YG C20 H23 N3 O2 S2 CC(c1ccccc....
49 1YKR ic50 = 0.56 uM 628 C20 H14 Cl2 N4 O3 S c1cc(c(c(c....
50 1PXN Ki ~ 0.32 uM CK6 C15 H15 N5 O S Cc1c(sc(n1....
51 1CKP - PVB C20 H25 Cl N6 O3 CC(C)C(CO)....
52 1KE6 ic50 = 5.7 nM LS2 C17 H15 N5 O3 S2 CNS(=O)(=O....
53 2C6K ic50 = 0.73 uM DT2 C17 H21 N7 O2 S c1cc(ccc1N....
54 2R3Q - 5SC C19 H16 Br N5 O Cc1ccccc1c....
55 2R3J ic50 = 10 nM SCJ C18 H14 Br N5 c1ccc(cc1)....
56 3IG7 ic50 = 9 nM EFP C18 H22 N4 O3 CC(=O)NC1C....
57 2VTS ic50 = 0.03 uM LZC C16 H23 N7 CC(C)Nc1cc....
58 1P2A ic50 = 12 nM 5BN C17 H15 F N4 O c1cc([nH]c....
59 2BHE ic50 = 1 uM BRY C16 H9 Br N2 O2 c1ccc2c(c1....
60 3UNK ic50 = 15 uM 0BY C17 H13 Cl N4 O2 c1ccc(c(c1....
61 1OIT ic50 < 0.003 uM HDT C17 H14 N6 O2 S c1ccn2c(c1....
62 2VTQ ic50 = 0.14 uM LZA C16 H17 F2 N5 O2 c1cc(c(c(c....
63 3NS9 ic50 = 0.003 uM NS9 C20 H27 N5 O3 CC(C)c1cnn....
64 2C68 ic50 = 1.8 uM CT6 C18 H15 Br N5 c1cc(cc(c1....
65 3TIZ - 3TI C17 H13 N O2 c1ccc2c(c1....
66 3PXY ic50 = 5.9 uM JWS C10 H11 N5 O2 COc1ccc(c(....
67 1H01 ic50 = 22 uM FAL C21 H23 Cl2 N5 O2 CN(C)CC(CO....
68 2EXM - ZIP C10 H13 N5 CC(=CCNc1c....
69 4BGH ic50 = 4 nM 3I6 C13 H16 Br N5 O3 S CC(CO)Nc1c....
70 2R3F ic50 = 500 nM SC8 C18 H13 Cl2 N5 c1cc(c(c(c....
71 2R3M ic50 = 10 nM SCX C19 H17 F2 N7 CCc1cnn2c1....
72 1GII - 1PU C17 H16 N4 O2 c1ccnc(c1)....
73 2R64 ic50 = 0.03 uM 740 C23 H27 N5 O3 S c1cc(ccc1C....
74 2C6O - 4SP C18 H22 N6 O3 S c1cc(ccc1N....
75 1V1K Ki = 35 uM 3FP C22 H23 F4 N5 O2 CN(C)CC(CO....
76 2VTJ ic50 = 1.9 uM LZ4 C10 H9 Cl N4 O2 S c1cc(ccc1N....
77 2C6L ic50 = 0.27 uM DT4 C17 H22 N8 O2 S c1cc(ccc1N....
78 2W06 - FRV C18 H20 N6 O2 S Cc1ncc(n1C....
79 3EZV - EZV C25 H25 N7 CN1CCN(CC1....
80 4EZ7 - STU C28 H26 N4 O3 CC12C(C(CC....
81 3PXZ Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
82 1W0X - OLO C15 H18 N6 O Cn1cnc2c1n....
83 2XMY Ki = 0.11 nM CDK C18 H21 N5 O4 S2 CC1=C(SC(=....
84 2UZO ic50 = 18 uM C62 C14 H10 N2 O5 S2 c1cc(ccc1c....
85 2VTT ic50 = 0.044 uM LZD C16 H17 F2 N5 O2 c1cc(c(c(c....
86 1KE7 ic50 = 8.9 nM LS3 C20 H15 N3 O4 S c1cc2c(cc1....
87 2VU3 ic50 = 0.047 uM LZE C16 H17 Cl2 N5 O2 c1cc(c(c(c....
88 2B54 - D05 C20 H15 Cl3 N4 O3 CCc1c2c(n(....
89 1DM2 - HMD C11 H10 Br N5 O2 C1CNC(=O)C....
90 1DI8 ic50 = 1 uM DTQ C16 H15 N3 O3 COc1cc2c(c....
91 1GZ8 - MBP C10 H13 N5 O2 CC(C)C(=O)....
92 3PY0 ic50 = 0.13 uM SU9 C13 H11 N3 O2 COc1ccc2c(....
93 2VTR ic50 = 1.5 uM LZB C10 H10 Cl N5 CC(C)Nc1cc....
94 1E1X Ki = 1.3 uM NW1 C11 H17 N5 O2 C1CCC(CC1)....
95 1GIJ - 2PU C19 H22 N6 O2 c1cc2c(c(c....
96 3UNJ ic50 = 11 uM 0BX C17 H14 N4 O2 c1ccc(cc1)....
97 2A0C - CK9 C19 H26 N6 O2 CCC(CO)Nc1....
98 3TIY - TIY C11 H8 O5 c1c2c(c(c(....
99 2R3I ic50 = 1000 nM SCF C18 H14 F N5 c1ccc(c(c1....
100 2R3P ic50 = 900 nM 3SC C19 H12 Cl2 N6 S c1cc(c(c(c....
101 1KE8 ic50 = 1000 nM LS4 C18 H14 N4 O3 S2 c1ccc2c(c1....
102 2C6I ic50 = 11 uM DT1 C18 H22 N6 O3 S c1cc(ccc1N....
103 1VYZ ic50 = 290 nM N5B C13 H13 N3 O c1ccc(cc1)....
104 3WBL ic50 = 23 uM PDY C20 H26 N6 O CCOc1ccc(c....
105 1PXP Ki ~ 0.22 uM CK8 C17 H19 N5 S Cc1c(sc(n1....
106 4RJ3 ic50 = 93 nM 3QS C22 H28 N6 O COC1CCN(CC....
107 2VTN ic50 = 0.85 uM LZ7 C12 H11 F N4 O2 CC(=O)Nc1c....
108 1AQ1 - STU C28 H26 N4 O3 CC12C(C(CC....
109 2UZN ic50 = 0.03 uM C96 C15 H13 N3 O4 S2 [H]N=C1NC(....
110 2B55 ic50 = 96 nM D31 C24 H31 N5 O2 c1cc-2c(c(....
111 2C6M ic50 = 0.35 uM DT5 C17 H20 N6 O3 S c1cc(ccc1N....
112 3PJ8 - 404 C19 H26 N6 O CCC(CO)Nc1....
113 3LFQ - A28 C17 H15 F2 N3 O CCCC(=O)Nc....
114 2R3L ic50 = 100 nM SCW C18 H14 Br N5 c1ccc(cc1)....
115 2W05 ic50 = 0.001 uM FRT C20 H26 N6 O3 S Cc1ncc(n1C....
116 1H08 - BYP BWP n/a n/a
117 2XNB Ki = 149 nM Y8L C19 H22 N6 O S CC1=C(SC(=....
118 1HCK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
119 1B38 Kd = 0.254 uM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
120 2B52 ic50 = 8 nM D42 C21 H23 N7 O2 S Cc1c(sc(n1....
121 1PXL - CK4 C16 H13 F3 N4 S Cc1c(sc(n1....
122 2R3H ic50 = 20000 nM SCE C13 H13 N5 Cc1cnc2n1c....
123 3LFN Ki = 3160 nM A27 C23 H21 N3 O2 CCCC(=O)Nc....
124 3S2P ic50 = 0.068 uM PMU C17 H22 N4 O3 CC(C)c1cc(....
125 2R3O ic50 = 600 nM 2SC C19 H17 N5 O c1ccc(cc1)....
126 3IGG ic50 = 95 nM EFQ C16 H19 N3 O3 COc1ccc(cc....
127 1R78 ic50 = 3 nM FMD C20 H20 F N3 O4 CC(C(C(C#C....
128 2FVD Ki = 0.003 uM LIA C18 H21 F2 N5 O4 S COc1ccc(c(....
129 2VTL ic50 = 97 uM LZ5 C10 H9 N3 O c1ccc(cc1)....
130 3PY1 Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
131 1KE9 ic50 = 660 nM LS5 C16 H15 N5 O3 S c1ccc2c(c1....
132 2A4L ic50 = 0.4 uM RRC C19 H26 N6 O CCC(CO)Nc1....
133 1Y8Y ic50 = 2 uM CT7 C13 H11 Cl N4 O2 S CS(=O)(=O)....
134 1OIR ic50 = 0.032 uM HDY C23 H26 N6 O2 Cc1c(n2ccc....
135 1PXJ - CK2 C9 H10 N4 S Cc1c(sc(n1....
136 2VTO ic50 = 0.14 uM LZ8 C17 H13 F N4 O2 c1ccc(cc1)....
137 1PYE ic50 = 0.32 uM PM1 C21 H13 F2 N3 O2 c1ccc(cc1)....
138 2BTR ic50 = 95 nM U73 C13 H15 N3 O S CC(C)C1=CN....
139 2VTA ic50 = 185 uM LZ1 C7 H6 N2 c1ccc2c(c1....
140 4EZ3 - 0S0 C11 H10 N4 O4 S c1cc(ccc1N....
141 3EZR - EZR C26 H27 N7 O CN1CCN(CC1....
142 3ULI ic50 = 0.07 uM 1N3 C21 H25 Br N6 O2 COc1ccc(cc....
143 2DS1 ic50 = 6.4 nM 1CD C22 H21 N5 O3 CC1CC2CN1C....
144 1H07 ic50 = 3 uM MFP C24 H27 Br N6 O2 Cc1ccc(c(c....
145 2B53 ic50 = 0.6 uM D23 C19 H19 F3 N4 CC(C)(C)Nc....
146 2DUV ic50 = 0.087 uM 371 C19 H17 N O7 S Cc1cc2c(c(....
147 2VTH ic50 = 120 uM LZ2 C10 H9 N O3 S c1cc2c(ccc....
148 1KE5 ic50 = 560 nM LS1 C16 H15 N3 O3 S CNS(=O)(=O....
149 3FZ1 - B98 C13 H15 N3 O2 S COc1ccc2c(....
150 1WCC ic50 = 350 uM CIG C4 H4 Cl N3 c1c(nc(cn1....
151 4ACM Ki = 210 nM 7YG C20 H23 N7 O3 S CN(C)CCNS(....
152 2C5Y ic50 = 0.25 uM MTW C19 H15 N7 O2 c1cc(cc(c1....
153 1PXO Ki = 2 nM CK7 C14 H12 N6 O2 S Cc1c(sc(n1....
154 1H00 ic50 = 38 uM FAP C21 H23 F2 N5 O2 CN(C)CC(CO....
155 2R3R - 6SC C18 H14 Br N5 c1ccc(cc1)....
156 2R3K ic50 = 100 nM SCQ C18 H14 Br N5 c1ccc(cc1)....
157 2V0D - C53 C9 H7 N3 O S [H]N=C1NC(....
158 1B39 Kd = 0.12 uM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
159 2W1H ic50 = 0.052 uM L0F C17 H13 N5 O c1ccc(cc1)....
160 1Y91 ic50 = 0.059 uM CT9 C23 H33 N7 O2 S CC(C)c1cnn....
161 2ZJW ic50 = 0.04 uM REF C14 H6 O8 c1c2c-3c(c....
162 3AT4 Kd = 2.26 nM CCK C20 H20 N6 O2 CC(C)Nc1cc....
163 3OWJ Ki = 0.86 uM 1EL C17 H14 N2 O2 Cc1c2c(c(c....
164 3MB7 ic50 = 200 nM 14I C16 H8 O6 c1cc2c(cc(....
165 2E9O ic50 = 20 nM A58 C25 H27 N3 O2 CC1CCC(CC1....
166 2WMQ - ZYQ C9 H11 N3 O2 S CC(=O)Nc1n....
167 2C3J Ki = 0.659 uM DBQ C11 H11 N5 O2 c1c[nH]c2c....
168 2YM7 ic50 = 0.13 uM YM7 C15 H18 N8 c1c(ncnc1N....
169 2X8I ic50 = 0.19 uM X8I C17 H13 N3 O2 CC1=CC2=NN....
170 2YDJ ic50 = 0.005 uM YDJ C17 H19 F N4 O2 S c1cc(cc(c1....
171 4QYE ic50 = 1.2 uM 3DL C17 H12 N2 O3 c1cc(cc(c1....
172 2BRO ic50 = 1.4 uM DF2 C21 H20 N4 O2 c1ccc(cc1)....
173 2BRG ic50 = 6.1 uM DFY C21 H19 N3 O2 CN(CCO)c1c....
174 2YM5 ic50 = 0.43 uM YM5 C18 H21 N5 O2 c1cc(cc(c1....
175 4HYH ic50 = 1 nM 1AM C22 H22 N6 O3 S COc1ccc2c(....
176 2CGU ic50 = 13.4 uM 3A3 C17 H13 N O7 c1cc-2c(cc....
177 1NVS Ki = 15 nM UCM C24 H15 N3 O3 c1ccc2c(c1....
178 2YDK ic50 = 0.007 uM YDK C17 H20 N4 O2 S c1ccc(cc1)....
179 3OT3 ic50 = 0.005 uM 22K C16 H20 Br N7 Cn1cc(cn1)....
180 2WMR ic50 = 52 uM ZYR C10 H10 N2 O S C1CCc2c(c3....
181 3PA5 ic50 = 2 nM C73 C17 H19 Cl N4 O2 S c1cc(ccc1c....
182 2WMV ic50 = 9.2 uM ZYV C10 H14 N6 O c1[nH]c2c(....
183 2BRH ic50 = 22 uM DFW C20 H15 N3 O3 c1ccc(cc1)....
184 1NVR Ki = 7.8 nM STU C28 H26 N4 O3 CC12C(C(CC....
185 2CGX ic50 = 15.6 uM 3D3 C7 H8 N6 O S c1nc(c2c(n....
186 3OT8 ic50 = 0.009 uM MI5 C19 H22 N8 S Cc1cc(sn1)....
187 2YM4 ic50 = 1.5 uM 4YM C21 H22 N6 O3 CCOC(=O)c1....
188 4HYI ic50 = 2 nM 1AO C21 H20 N6 O S c1ccc2c(c1....
189 4QYF - 3DV C17 H13 N3 O3 c1cc(cc(c1....
190 3JVS Ki = 0.146 uM AGY C22 H22 N4 O4 CC(C)(C)c1....
191 2WMW ic50 = 0.39 uM ZYW C11 H14 Br N5 O c1c2c(c(cn....
192 2BR1 Ki = 7.2 uM PFP C22 H21 N3 O4 COc1ccc(cc....
193 2XF0 ic50 = 30 uM 4UB C15 H11 N5 c1ccc(cc1)....
194 2C3L Ki = 0.026 uM IDZ C14 H10 N4 c1ccc2c(c1....
195 2YM6 ic50 = 0.88 uM YM6 C14 H16 N6 O c1cncc2c1c....
196 2X8E ic50 = 0.014 uM X8E C16 H12 N4 O CC1=CC2=NN....
197 4QYG ic50 = 0.0041 uM 3DW C22 H21 N5 O2 CN1CCN(CC1....
198 2X8D ic50 = 0.8 uM X8D C11 H9 N3 O CC1=CC2=NN....
199 2YEX ic50 = 0.0001 uM YEX C15 H12 N4 O CC1=CC2=NN....
200 2BRM Ki = 1.3 uM DFZ C20 H18 N4 O c1ccc(cc1)....
201 2XEZ ic50 = 1.5 uM XEZ C12 H9 N7 c1c[nH]nc1....
202 1NVQ Ki = 5.6 nM UCN C28 H26 N4 O4 CC12C(C(CC....
203 3PA4 ic50 = 3 nM C72 C19 H19 Cl N4 O S c1cc(ccc1c....
204 2E9N ic50 = 6.2 nM 76A C29 H27 N3 O3 c1cc(ccc1c....
205 2YM3 ic50 = 1.2 uM YM3 C14 H19 N5 O3 CCOC(=O)c1....
206 2YDI - YDI C16 H20 N4 O3 S CN(C)CCOc1....
207 3EHA - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
208 1JKL - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
209 1JKK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
210 3F5G - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
211 3F5U - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
212 1P4F - DRG C12 H11 N3 c1ccc-2c(c....
213 4TXC Kd = 0.24 uM 38G C24 H27 N5 O3 CN(C)CCNC(....
214 2YAK ic50 = 2 nM OSV C27 H31 F N4 O3 Ru S4 CC(C)Oc1cc....
215 3EH9 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
216 1IG1 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
217 3SHE - I85 C24 H22 F3 N5 O2 c1cc(cc(c1....
218 3R1N - 05B C22 H21 N5 O3 c1cc2c(cc1....
219 4AU8 ic50 = 551 nM Z3R C11 H8 N2 O2 S3 c1ccc2c(c1....
220 1REJ Ki = 5 nM B1L C20 H22 N2 O5 c1cc(ccc1C....
221 3BWJ ic50 = 2.6 uM ARX C28 H47 N15 O7 c1nc(c2c(n....
222 3AG9 Ki = 9 nM A02 C40 H70 N18 O9 c1nc(c2c(n....
223 3AGL Ki = 16 nM A03 C37 H63 N17 O9 CC(C(=O)NC....
224 1RE8 Ki = 0.3 nM BD2 C27 H26 N2 O6 c1ccc(c(c1....
225 2VZ6 - FEF C20 H19 N3 O4 c1ccc2c(c1....
226 2Z7Q - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
227 2Z7R ic50 = 3 nM STU C28 H26 N4 O3 CC12C(C(CC....
228 3QD4 ic50 = 0.00000001 M 3Q6 C22 H30 N8 O2 CC1CC(CN(C....
229 1Z5M ic50 = 30 nM LI8 C23 H31 Br N8 O3 CC(C)(C(=O....
230 3RCJ ic50 = 0.8 uM 3RC C16 H13 N5 c1ccc(cc1)....
231 2PE0 - 39Z C14 H12 N2 O2 CC(c1ccc[n....
232 4CT2 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
233 3QD0 ic50 = 0.00000001 M 3Q4 C24 H26 N8 O CC1CCC(CN1....
234 3ORZ - BI4 C27 H26 N4 O2 CN1CCCC1CC....
235 3HRC - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
236 3ION ic50 = 8 nM 8H1 C28 H27 N5 O3 COc1cc2c3c....
237 2XCH ic50 = 374 nM CKG C22 H25 N7 O c1c2c(nc(n....
238 4AW0 - MJF C18 H15 Cl O5 c1ccc(cc1)....
239 1UU7 ic50 = 14 uM BI2 C27 H26 N4 O2 CN1CCCC1CC....
240 3OTU - BI4 C27 H26 N4 O2 CN1CCCC1CC....
241 3HRF Kd = 10.3 uM P47 C17 H15 Cl O2 c1ccc(cc1)....
242 3QCS ic50 = 0.00000001 M 3Q1 C15 H17 N7 O c1cc2c(cc1....
243 3QCX ic50 = 0.00000001 M 3Q2 C16 H19 N7 O CC1COCCN1c....
244 1UU3 ic50 = 0.75 uM LY4 C28 H28 N4 O3 CN(C)CC1CC....
245 1H1W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
246 3QC4 ic50 = 0.002 uM MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
247 4AW1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
248 3QCY ic50 = 0.00000001 M 3Q3 C22 H22 N8 O2 c1ccc(cc1)....
249 1UU8 ic50 = 9 uM BI1 C25 H24 N4 O2 CN(C)CCCn1....
250 4CT1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
251 2PE2 - 464 C28 H30 N6 O3 c1cc(cc(c1....
252 3H9O ic50 = 70 nM 9BD C19 H19 N5 O3 COCCOc1cc2....
253 4A07 - AZ7 C17 H13 Cl3 N2 O2 c1cc(ccc1C....
254 4KS7 - X4Z C25 H28 N8 O S Cc1nc2ccsc....
255 4KS8 - B49 C22 H27 F N4 O2 CCN(CC)CCN....
256 4DGO ic50 = 0.57 uM 0JW C10 H10 N2 O3 c1cc(c(cc1....
257 4DGM ic50 = 1.2 uM AGI C15 H10 O5 c1cc(ccc1C....
258 2PVJ Ki = 0.005 uM P44 C19 H21 N7 c1ccc(cc1)....
259 4DGN ic50 = 0.35 uM LU2 C15 H10 O6 c1cc(c(cc1....
260 1M2Q - MNX C13 H7 N O6 c1cc(c2c(c....
261 1OM1 Ki = 0.17 uM IQA C17 H12 N2 O3 c1ccc2c(c1....
262 1ZOH Ki = 0.1 uM K44 C10 H7 Br4 N3 CN1CCn2c1n....
263 1M2R - MNY C14 H10 N2 O4 c1cc(c2c(c....
264 3KXN - K8X C7 H2 I4 N2 c1[nH]c2c(....
265 2PVK Ki = 0.008 uM P45 C19 H14 Cl N7 c1ccc(cc1)....
266 1DAY - GNP C10 H17 N6 O13 P3 c1nc2c(n1C....
267 3SLS - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
268 4AUA ic50 = 7.2 uM 4AU C12 H9 N3 O c1ccc2c(c1....
269 2QHN ic50 = 980 nM 582 C13 H13 N3 O CCN1c2cccc....
270 3TKI ic50 = 0.05 nM S25 C20 H23 N7 O2 S c1cnc(cc1N....
271 2HXQ ic50 = 144 nM 373 C24 H26 N4 O c1ccc2c(c1....
272 2QHM ic50 = 660 nM 7CS C16 H19 N3 O2 CN1C2CCC1C....
273 2R0U ic50 = 1 nM M54 C25 H22 N4 O2 c1cc(cc(c1....
274 3TKH ic50 = 47 nM 07S C23 H27 N7 O2 S c1cc(cnc1)....
275 2HXL ic50 = 12 nM 422 C23 H24 N6 c1cc2c(cc1....
276 2HOG ic50 = 0.3 nM 710 C24 H25 N7 O c1cc2c(cc1....
277 2XK6 - EQH C18 H21 N3 O2 S c1csc(c1C2....
278 2WQO - VGK C21 H20 N2 O5 COc1cc(cc(....
279 2XKE ic50 = 4.2 uM WI2 C17 H20 N4 O3 COc1cccc(c....
280 2XNN - 430 C21 H16 F3 N3 O2 S CC(c1ccccc....
281 2XK7 ic50 = 1.5 uM 30E C21 H28 N4 O5 CCC1CN(CCC....
282 4EQU - G6I C30 H24 F3 N7 O2 Cc1ccc(cc1....
283 2J7T - 274 C28 H30 Cl N5 O4 S Cc1c([nH]c....
284 3GGF - GVD C22 H19 N7 c1ccc2c(c1....
285 3D0E ic50 = 13 nM G93 C21 H27 N7 O3 CCn1c2c(cn....
286 2JDO ic50 = 0.23 uM I5S C20 H22 Cl N3 O3 S c1cc2cnccc....
287 2X39 ic50 = 30 nM X39 C19 H21 Cl N6 O c1cc(ccc1C....
288 3E87 - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
289 1O6K - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
290 3E88 Ki = 2 nM G96 C24 H27 N7 O3 CCn1c2cc(n....
291 4OBQ ic50 = 0.065 uM 2QT C20 H20 F N5 O c1cc2c(cc1....
292 4U43 Kd = 48 uM 3D8 C11 H9 N5 c1cc(cnc1)....
293 4OBP ic50 = 0.017 uM 2QU C12 H8 F N5 c1cc(nc2c1....
294 4OBO ic50 = 0.077 uM 2QV C14 H10 Cl N3 c1cc(cc(c1....
295 4U44 ic50 = 0.008 uM 3D9 C17 H13 N5 c1ccc(cc1)....
296 3DAK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
297 4NW5 ic50 = 0.02 uM 2NR C23 H21 F N2 O5 COc1cccc(c....
298 4EL9 - AFE C21 H20 O10 CC1C(C(C(C....
299 4NUS ic50 = 0.005 uM 2NK C22 H21 F2 N3 O CN1CCN(CC1....
300 4NW6 ic50 = 0.004 uM 2NS C23 H20 N4 O4 COc1cc(cc(....
301 4GRB ic50 = 17 nM 0XG C19 H18 N4 O4 S CN(C)C(=O)....
302 2YIT ic50 = 0.29 nM YIT C21 H24 N6 O2 CCCC(=NNC(....
303 2W0J ic50 = 240 nM ZAT C19 H24 N10 O [H]N=C(N)N....
304 2W7X ic50 = 138 nM D1A C18 H17 N7 O3 CC(=NNC(=N....
305 4A9U - A9U C27 H28 N4 O2 c1ccc(cc1)....
306 2XK9 ic50 = 0.03 nM XK9 C18 H17 N7 O4 CC(=NNC(=N....
307 2YCS ic50 = 1.36 nM NXP C18 H18 N6 O CC(=NNC(=N....
308 2YCF ic50 = 0.7 nM YCF C19 H24 N10 O3 CC(=NNC(=N....
309 2WTI ic50 = 0.092 uM WTI C18 H15 N3 O3 S c1cc(ccc1c....
310 2YIR ic50 = 0.17 nM YIR C20 H19 N7 O3 c1cc2cc([n....
311 2XBJ ic50 = 0.86 uM XBJ C23 H27 F N4 O4 CC(C)(C1CN....
312 4BDI ic50 = 227.7 uM HAU C14 H19 N3 O2 Cc1ccc(nc1....
313 2XM9 ic50 = 0.009 uM LWH C21 H20 N6 O c1ccc2c(c1....
314 2YCR ic50 = 69.6 nM HCW C23 H28 N10 O CC(=NNC1=N....
315 2YIQ ic50 = 12.67 nM YIQ C20 H19 N7 O CC(=NNC(=N....
316 2WTJ ic50 = 0.7 uM WTJ C16 H20 N4 O3 S CN(C)CCNC(....
317 2CN5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
318 4FII - ARG PRO LYS PRO LEU VAL ASP PRO n/a n/a
319 4JDK - ARG ARG ARG ARG SER TRP TYR n/a n/a
320 4JDI - ARG ARG ARG ARG SER TRP TYR n/a n/a
321 3A7H - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
322 3A7J - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
323 3A7I - ADE C5 H5 N5 c1[nH]c2c(....
324 1U5R - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
325 3EQC - AGS C10 H16 N5 O12 P3 S c1nc(c2c(n....
326 3EQH - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
327 3EQI - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
328 2J51 - DKI C15 H13 F2 N7 O2 S2 c1cc(c(c(c....
329 2UV2 - GVD C22 H19 N7 c1ccc2c(c1....
330 2JFL - DKI C15 H13 F2 N7 O2 S2 c1cc(c(c(c....
331 4FG9 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
332 4FG8 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
333 4JQE - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
334 1QL6 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
335 1PHK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
336 2F57 - 23D C19 H24 Cl N7 CCn1cnc2c1....
337 1XJD Ki = 0.33 nM STU C28 H26 N4 O3 CC12C(C(CC....
338 3A62 - STU C28 H26 N4 O3 CC12C(C(CC....
339 3WF9 ic50 = 567 nM FS7 C24 H25 N3 O5 S CC1CCc2c(c....
340 3WF8 ic50 = 232 nM F76 C23 H23 N3 O5 S c1ccc2c(c1....
341 4L3L - 5FI C19 H21 F3 N6 CCc1cncnc1....
342 3WE4 ic50 = 15 nM 5FI C19 H21 F3 N6 CCc1cncnc1....
343 3WF7 ic50 = 206 nM FS9 C18 H17 F3 N6 O c1cc(cc(c1....
344 4L3J - 5FI C19 H21 F3 N6 CCc1cncnc1....
345 3WF6 ic50 = 33 nM FZ9 C18 H16 N6 c1ccc2c(c1....
346 4OTI ic50 = 43 nM MI1 C16 H20 N6 O CC1CCN(CC1....
347 2VN9 - GVD C22 H19 N7 c1ccc2c(c1....
348 4EJN ic50 = 0.005 uM 0R4 C33 H26 F N7 O2 CC(=O)Nc1c....
349 2V7O - DRN C25 H23 N5 O2 S [H]N=C(N)S....
350 2WEI ic50 = 3.4 nM VGG C17 H21 N5 Cc1cccc(c1....
351 3CQW ic50 = 42 nM CQW C12 H11 Cl N6 c1c(c2c([n....
352 3MV5 ic50 = 180 nM XFE C11 H15 N5 Cc1c[nH]c2....
353 3QKL - SMR C29 H40 N4 O5 S CCOCCN(CC(....
354 4GV1 ic50 = 3 nM 0XZ C21 H25 Cl N6 O2 c1cc(ccc1C....
355 3QKM ic50 = 0.038 uM SM9 C31 H43 N5 O4 S CCOCCN(CC(....
356 3MVH ic50 = 0.5 nM WFE C20 H22 F2 N6 O CCc1c[nH]c....
357 3CQU ic50 = 151 nM CQU C15 H13 N7 Cc1[nH]c(n....
358 3Q53 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
359 4O0R Ki = 0.036 uM X4Z C25 H28 N8 O S Cc1nc2ccsc....
360 4EQC ic50 = 0.008 uM XR1 C29 H28 Cl N7 O S CCN1c2c(cn....
361 3FY0 ic50 = 1090 nM DW1 C23 H13 N3 O4 Ru C1=CC(C=C1....
362 3FXZ ic50 = 130 nM FLL C30 H18 Cl F N5 O4 Ru c1ccc(cc1)....
363 3Q4Z - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
364 3GC0 - AMP C10 H14 N5 O7 P c1nc(c2c(n....
365 3MFU - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
366 3C0I - 3AM C10 H14 N5 O7 P c1nc(c2c(n....
367 3MFS - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
368 3MFR - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
369 3TXO ic50 = 9 nM 07U C17 H19 N5 CC(C)(CNc1....
370 4OTH ic50 = 9 nM DRN C25 H23 N5 O2 S [H]N=C(N)S....
371 2J90 - IZA C18 H16 F N3 O CC(C)(C)c1....
372 3BHY - 7CP C18 H18 Cl2 N4 O Cn1c2c(ccc....
373 1V0P ic50 = 0.13 uM PVB C20 H25 Cl N6 O3 CC(C)C(CO)....
374 1V0O ic50 = 5.5 uM INR C16 H10 N2 O5 S c1ccc2c(c1....
375 4NJD ic50 = 0.79 uM NJD C21 H20 N8 O COc1nc(nc(....
376 4APP Ki = 0.064 uM N53 C33 H36 N6 O3 CC1(c2c(c(....
377 4O0X Ki = 0.068 uM 2OQ C19 H20 N6 O Cc1nc2ccc(....
378 2X4Z Ki = 18.7 nM X4Z C25 H28 N8 O S Cc1nc2ccsc....
379 4O0Y Ki = 0.06 uM 2OO C17 H19 N7 O CCNc1nc2cc....
380 2CDZ - 23D C19 H24 Cl N7 CCn1cnc2c1....
381 3A8W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
382 3AQV - TAK C24 H25 N5 O c1cc(ccc1c....
383 3WAR - NIO C6 H5 N O2 c1cc(cnc1)....
384 2YAB - AMP C10 H14 N5 O7 P c1nc(c2c(n....
385 2YAA - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 0XZ; Similar ligands found: 5
No: Ligand ECFP6 Tc MDL keys Tc
1 0XZ 1 1
2 X39 0.623656 0.898551
3 M04 0.505263 0.768116
4 M05 0.5 0.742857
5 M03 0.5 0.753623
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3MVH; Ligand: WFE; Similar sites found: 378
This union binding pocket(no: 1) in the query (biounit: 3mvh.bio1) has 53 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc)
1 2F2U M77 0.00000000009292 0.84255
2 2F2U M77 0.0000000002503 0.82055
3 2PVF ACP 0.0000000001778 0.79076
4 3IDB ANP 0.00000000007627 0.75583
5 2A19 ANP 0.000000007361 0.74549
6 4E4N 0NL 0.00000000114 0.74183
7 1U59 STU 0.000000001234 0.74022
8 4BCN T9N 0.000000003923 0.7369
9 4E4N 0NL 0.0000000008994 0.73669
10 4CFU 2WC 0.00000001187 0.72383
11 4E6Q 0NV 0.000000003474 0.70978
12 4CFU 2WC 0.00000001412 0.70973
13 4X0M 3WA 0.0000002546 0.70529
14 4BCN T9N 0.00000003053 0.70334
15 3BRB ADP 0.00000009411 0.69957
16 4IVD 15T 0.000000004503 0.69576
17 2ZV2 609 0.00000006987 0.69554
18 4IVD 15T 0.000000005052 0.69351
19 4E6Q 0NV 0.000000006556 0.68843
20 1O9U ADZ 0.0000004363 0.68446
21 2B9J ADP 0.00000003465 0.68132
22 2WU6 DKI 0.000000006498 0.67229
23 3EYG MI1 0.00000002421 0.67112
24 4IDT T28 0.00000005707 0.67097
25 3PVW QRX 0.000000002072 0.67057
26 4K77 1Q4 0.0000003551 0.66937
27 2B9I ADP 0.00000004628 0.66656
28 3HMO STU 0.00000008728 0.66215
29 2JLD AG1 0.000000001123 0.66019
30 3BRB ADP 0.0000005868 0.65795
31 4CNH 3U9 0.00000009318 0.65233
32 3ALN ANP 0.0000001624 0.64927
33 4K77 1Q4 0.0000006509 0.64599
34 4FL3 ANP 0.00000004104 0.64497
35 4CCU AWF 0.0000002551 0.63989
36 2JLD AG1 0.000000002143 0.63657
37 4IVB 1J5 0.0000005051 0.63386
38 4EHZ JAK 0.0000007668 0.63343
39 4PNI KQQ 0.000000008292 0.63265
40 4CNH 3U9 0.000001267 0.63121
41 4IVB 1J5 0.0000005113 0.62546
42 4IVC 1J6 0.0000002453 0.62501
43 4IVC 1J6 0.0000002479 0.62479
44 2JLD AG1 0.000000003226 0.62392
45 4EHZ JAK 0.000001456 0.61952
46 4EHZ JAK 0.000001554 0.6181
47 4IZY 1J2 0.0000002889 0.61451
48 3GNI ATP 0.0000003073 0.61331
49 4EHZ JAK 0.000001952 0.61317
50 4AOI 4K0 0.000001418 0.61196
51 3ALN ANP 0.00000411 0.60509
52 4C4F 7CE 0.0000005974 0.60033
53 4E1Z 0MX 0.0000003198 0.59908
54 3ALN ANP 0.0000006469 0.59878
55 2QLU ADE 0.00002159 0.59541
56 4FOC 0UU 0.000002795 0.5902
57 3IGO ANP 0.00000072 0.59011
58 4CD0 AWJ 0.000000727 0.58993
59 2QCS ANP 0.0000000005851 0.58692
60 4Q5H ANP 0.000002378 0.58649
61 4NM5 ADP 0.0000000001574 0.58176
62 4NM5 ADP 0.0000000001574 0.58176
63 4AT3 LTI 0.00000433 0.58112
64 3FHI ANP 0.000000001269 0.57722
65 4FOB 0US 0.000001661 0.56812
66 2CSN CKI 0.0000000026 0.56789
67 2PUL ACP 0.00001043 0.56288
68 2PUL ACP 0.00001043 0.56288
69 3TDV GDP 0.000007722 0.56255
70 3TDV GDP 0.000009372 0.55862
71 3LXK MI1 0.0000009078 0.55698
72 4MQ1 2C3 0.0000000006633 0.55639
73 3TTI KBI 0.000008231 0.55504
74 2PYW ADP 0.000006201 0.55465
75 2O2U 738 0.00002382 0.55213
76 4GYI ADP 0.00003341 0.55157
77 2GU8 796 0.00000000005082 0.55137
78 3GC8 B45 0.000005676 0.55057
79 4DCE 0JF 0.000006097 0.5492
80 4MQ1 2C3 0.0000000006407 0.54806
81 4QTB 38Z 0.0000000311 0.54721
82 3PP0 03Q 0.000005645 0.54513
83 3THB 3TA 0.0000002899 0.54227
84 3THB 3TA 0.0000002899 0.54227
85 2IF8 ADP 0.0001306 0.54221
86 4MQ1 2C3 0.000000001053 0.54214
87 4QTB 38Z 0.00000004879 0.54111
88 3SXS PP2 0.00001256 0.54086
89 3GC8 B45 0.00000801 0.53855
90 1TQP ATP 0.000006047 0.53853
91 1VJY 460 0.000003491 0.53831
92 3LQ8 88Z 0.000001131 0.53792
93 4DCE 0JF 0.00001549 0.53678
94 1OPK P16 0.0000134 0.53412
95 1IA9 ANP 0.00002501 0.53291
96 1OUK 084 0.00001819 0.52892
97 4F4P 0SB 0.000001411 0.52874
98 3VHE 42Q 0.000002771 0.52804
99 3LKM AMP 0.00003361 0.52702
100 3PDT ADP 0.00007789 0.52701
101 4I6H 1C8 0.00004943 0.52482
102 4MQ1 2C3 0.000000002262 0.52462
103 4MK0 29X 0.00000004007 0.52284
104 3PP0 03Q 0.000008977 0.52149
105 3LXN MI1 0.000000008216 0.52007
106 3I0O ADP 0.0001972 0.51916
107 3I0O ADP 0.0001972 0.51916
108 4AG8 AXI 0.000002894 0.51852
109 4GJ3 0XP 0.0000003897 0.51814
110 3SRV S19 0.0000000007543 0.5161
111 4I5C C5I 0.000000005679 0.51605
112 4H3P ANP 0.000000003047 0.51543
113 3RI1 3RH 0.000000123 0.51395
114 4E93 GUI 0.000003884 0.5137
115 4MXO DB8 0.000009304 0.51369
116 4K33 ACP 0.000000009091 0.51367
117 1Y57 MPZ 0.00000003593 0.5132
118 3RI1 3RH 0.0000001643 0.51309
119 3SXF BK5 0.000001577 0.51154
120 4H3P ANP 0.000000004362 0.51133
121 3VRY B43 0.00002068 0.51115
122 3KMW ATP 0.0001315 0.51027
123 3GQI ACP 0.000000005334 0.50972
124 3FI3 JK2 0.00008558 0.50841
125 2Y6O 1N1 0.00005403 0.50742
126 4I5C C5I 0.00000001257 0.50726
127 3SRV S19 0.000000000691 0.50606
128 4BBF O19 0.00000001297 0.50505
129 4KBA 1QM 0.0003055 0.50356
130 4E6D 0NU 0.0000000213 0.50176
131 3VRY B43 0.00002161 0.50151
132 4BHN BH9 0.00000005281 0.49789
133 4H3Q ANP 0.0000001242 0.49788
134 3F7Z 34O 0.000000001325 0.49519
135 1W2D ADP 0.0006091 0.49412
136 3PLS ANP 0.00000001003 0.49406
137 4BHN BH9 0.0000002122 0.49146
138 3F7Z 34O 0.000000006073 0.49138
139 4F65 0S9 0.00001172 0.49054
140 2P2I 608 0.00008194 0.49044
141 4BBF O19 0.00000002278 0.49035
142 1W2D ADP 0.0007484 0.48955
143 2P2I 608 0.00008675 0.48939
144 2X2M X2M 0.000000103 0.48851
145 2QU6 857 0.0001169 0.48817
146 4KBA 1QM 0.0003018 0.48805
147 2VAG V25 0.00000003142 0.4875
148 4MXO DB8 0.00003315 0.4873
149 4O1P ANP 0.00000002617 0.48648
150 2XB7 GUI 0.00001672 0.48629
151 4OAV ACP 0.00000001057 0.4862
152 1AUX AGS 0.0003337 0.486
153 2B9H ADP 0.00000006802 0.48598
154 2EVA ADN 0.000002352 0.4858
155 4BBF O19 0.00000001344 0.48512
156 3BU5 ATP 0.00000002645 0.48473
157 1MQB ANP 0.00000009055 0.48456
158 3UIM ANP 0.00000004189 0.48437
159 3EQR T74 0.0000007393 0.48386
160 4O1P ANP 0.00000001665 0.4836
161 4KBA 1QM 0.0004873 0.48308
162 4NST ADP 0.00000004151 0.48296
163 3EQR T74 0.000001211 0.48254
164 3EQR T74 0.000001211 0.48254
165 4BBF O19 0.00000001737 0.48252
166 4NST ADP 0.00000004481 0.48162
167 3V8T 477 0.00002713 0.4812
168 3V8T 477 0.00002713 0.4812
169 4NWM 2P5 0.0000377 0.47958
170 2YW2 ATP 0.000297 0.47911
171 2B9F ADP 0.0000000706 0.47811
172 4WHZ 3NL 0.00002677 0.47741
173 1ZY5 ANP 0.00000003214 0.47691
174 2QU6 857 0.0001486 0.47542
175 3E8N ATP 0.000001638 0.47526
176 3E8N ATP 0.000001638 0.47526
177 3E8N VRA 0.000001638 0.47526
178 3E8N VRA 0.000001638 0.47526
179 1PME SB2 0.0000001986 0.47482
180 4FE2 AIR 0.001535 0.47359
181 4KBA 1QM 0.0006235 0.4733
182 4KBA 1QM 0.0006235 0.4733
183 3VPC ADP 0.0003391 0.47224
184 2BPM 529 0.000000178 0.47185
185 3BI6 396 0.0000003036 0.4718
186 1UNH IXM 0.00000001972 0.47017
187 4LH7 1X8 0.002443 0.46897
188 4CCB OFG 0.000000168 0.46887
189 2QHV OC9 0.002429 0.46853
190 2YW2 ATP 0.000513 0.46843
191 3VPB ADP 0.0002194 0.46835
192 1XKK FMM 0.00001661 0.4682
193 4PMM 31V 0.0004198 0.46816
194 2BPM 529 0.0000001383 0.46738
195 2H8H H8H 0.0000001116 0.46671
196 3ZJX BOG 0.004045 0.46639
197 2G30 ALA ALA PHE 0.0005794 0.46633
198 1BYG STU 0.00000003898 0.46589
199 3EYH IZA 0.0000001766 0.46581
200 3O0G 3O0 0.00000007681 0.46555
201 4BTK DTQ 0.0000002826 0.46511
202 3KF4 B90 0.00008026 0.46496
203 3V8T 477 0.000003323 0.46389
204 3KYF 5GP 5GP 0.002513 0.46264
205 4MKC 4MK 0.000000649 0.46249
206 4BCM T7Z 0.000000105 0.46216
207 3TZM 085 0.0000009467 0.46156
208 4CMT GWH 0.0000008847 0.46131
209 2XVD AS6 0.00001394 0.4591
210 4IWD 1JC 0.00004812 0.45889
211 4LO2 GAL BGC 0.005025 0.45787
212 4CMO YPW 0.0000002185 0.45769
213 2CFM AMP 0.003231 0.45705
214 2XG5 EC5 0.006077 0.45524
215 2XG5 EC2 0.006077 0.45524
216 3ZRM ZRM 0.0000003237 0.45494
217 4CTB KVC 0.000000949 0.4539
218 4E4L 0NH 0.0000003164 0.45372
219 1I7L ATP 0.0006276 0.45287
220 1I7L ATP 0.0006276 0.45287
221 4UWH JXM 0.002649 0.45218
222 4CLI 5P8 0.0000003939 0.45186
223 2QHS OCA 0.004089 0.45181
224 3ZJX BOG 0.007193 0.45122
225 4E4L 0NH 0.0000002393 0.45117
226 2OFV 242 0.00009972 0.45102
227 3ZJX BOG 0.007339 0.45074
228 4P5Z Q7M 0.00007457 0.45067
229 3ZJX BOG 0.007413 0.45055
230 1EHI ADP 0.001664 0.4493
231 4CTC J99 0.0000005284 0.44898
232 4FVQ ATP 0.000001861 0.44861
233 4E4L 0NH 0.0000003179 0.44829
234 3NW7 LGV 0.0002112 0.4482
235 3EKK GS2 0.000004563 0.44786
236 3W0O ADP 0.0003915 0.4475
237 1UNH IXM 0.00000007986 0.44748
238 1CM8 ANP 0.0000007046 0.44728
239 2IO8 ADP 0.0008526 0.44722
240 1CM8 ANP 0.0000007152 0.44624
241 4CLJ 5P8 0.0000006333 0.44529
242 4PU5 ANP 0.001231 0.44392
243 4BKJ STI 0.001609 0.44241
244 4DFU QUE 0.009644 0.44178
245 1ZP9 ATP 0.0000009368 0.44145
246 3W0O HY0 0.0004924 0.4404
247 4LO2 GAL BGC 0.008297 0.44032
248 4IX4 ADP 0.000005957 0.44027
249 1ZP9 ATP 0.000001187 0.43999
250 4DC2 ADE 0.0000000001012 0.4392
251 4CMU IV7 0.0000006921 0.43843
252 1PK8 ATP 0.001148 0.43836
253 1PK8 ATP 0.001191 0.43769
254 3RGF BAX 0.001469 0.43718
255 1ZP9 ATP 0.0000008578 0.43664
256 3K5I ADP 0.002646 0.43639
257 1ZP9 ATP 0.000001032 0.43525
258 3ORQ ADP 0.002986 0.43402
259 4PMT 31Y 0.000006259 0.43341
260 4E5W 0NT 0.000003205 0.43333
261 1K3A ACP 0.0000006672 0.43328
262 4EI4 0Q2 0.0000007586 0.43328
263 4CS9 AMP 0.006636 0.43285
264 3KRL KRL 0.000007366 0.43282
265 4EI4 0Q2 0.0000007804 0.43281
266 4NWM 2P5 0.00001686 0.43278
267 4BCQ TJF 0.0000001162 0.43215
268 2IVD ACJ 0.01009 0.4317
269 4ASE AV9 0.00005462 0.43096
270 3HZT J60 0.0000002054 0.43008
271 3SG8 TOY 0.0001447 0.42939
272 3SG8 TOY 0.0001447 0.42939
273 4DFU QUE 0.01406 0.42846
274 1D2S DHT 0.006864 0.42811
275 3QUP LUN 0.000003359 0.42784
276 3PTG 932 0.00000009638 0.42765
277 3E7O 35F 0.0002189 0.42754
278 4BKJ STI 0.002527 0.42715
279 4FFG LBS 0.01438 0.42713
280 4BCQ TJF 0.0000003461 0.4271
281 3V4S ATP 0.003633 0.4268
282 1ZTH ADP 0.0000009751 0.42674
283 2HK5 1BM 0.0000122 0.42673
284 3E7O 35F 0.0001891 0.42621
285 4NS0 PIO 0.02058 0.4259
286 3ZBF VGH 0.000002736 0.42583
287 1KC7 PPR 0.01563 0.42571
288 1KC7 PPR 0.01563 0.42571
289 4OCJ NDG 0.0006114 0.42525
290 4BBE 3O4 0.0000005044 0.42515
291 3KF4 B90 0.0007315 0.42483
292 3NKS ACJ 0.008128 0.42459
293 3NKS ACJ 0.008128 0.42459
294 4ORK GDP 0.000008359 0.4242
295 4CYI ATP 0.00001243 0.4239
296 3PFF ADP 0.008471 0.42373
297 3PFF ADP 0.008471 0.42373
298 4AXD ANP 0.0003594 0.42327
299 1Y8E SVR 0.02212 0.42313
300 4CYI ATP 0.00002077 0.42268
301 4HNF 16W 0.000002636 0.42172
302 1ZTH ADP 0.000000607 0.42157
303 4ORK GDP 0.000006075 0.42118
304 4ORK GDP 0.000001631 0.42105
305 4AZW ATP 0.00002137 0.42103
306 2Q7D ANP 0.003552 0.42087
307 3KYG 5GP 5GP 0.009767 0.42076
308 4KNB 1RU 0.000003638 0.42058
309 4ORK GDP 0.00000388 0.42029
310 2Q7D ANP 0.002746 0.41958
311 2Q7D ANP 0.002746 0.41958
312 1ZTH ADP 0.0000008066 0.41943
313 4KNB 1RU 0.000003255 0.41927
314 3NEM ATP 0.01771 0.41913
315 3K5I ADP 0.00645 0.41895
316 4CYI ATP 0.00001223 0.41888
317 2IVD ACJ 0.01559 0.4181
318 3VSV XYS 0.03014 0.41765
319 4CYI ATP 0.00001311 0.41757
320 1ZTH ADP 0.0000009206 0.417
321 4H1M 0YJ 0.0011 0.41477
322 3LQV ADE 0.0197 0.41467
323 2AGC DAO 0.02565 0.41466
324 1WBP ADP 0.0000009895 0.41465
325 2P2H 994 0.000002912 0.41445
326 4FK6 0UJ 0.00001091 0.41441
327 4FK6 0UJ 0.0000113 0.4144
328 4BBE 3O4 0.0000007616 0.41435
329 4CKR DI1 0.00384 0.4136
330 1GSA ADP 0.0001249 0.41339
331 1GSA ADP 0.0001249 0.41339
332 3UDZ ADP 0.00002433 0.41248
333 3UDZ ADP 0.0000282 0.41245
334 3UDZ ADP 0.0000282 0.41245
335 3U6H 03X 0.0009662 0.41188
336 4X2J 3WN 0.000004438 0.41117
337 3O0W MAN MAN MAN GLC 0.02524 0.41117
338 4X2K 3WO 0.000004438 0.41117
339 4TWC 37J 0.00001641 0.41107
340 3QBC B55 0.02298 0.41027
341 3QBC B55 0.02426 0.41003
342 2ZM3 575 0.000001115 0.4097
343 4FE2 ADP 0.024 0.40866
344 3SG8 TOY 0.0005959 0.40859
345 3AB4 THR 0.0339 0.40822
346 2G50 PYR 0.03735 0.40813
347 3DGY 2GP 0.04149 0.40782
348 3LXI CAM 0.04123 0.40756
349 3T5M AMP 0.04337 0.40756
350 1XDN ATP 0.02171 0.40736
351 2XCM ADP 0.02197 0.40711
352 1KDK DHT 0.008717 0.40706
353 2ZM3 575 0.000001744 0.40658
354 1W2D 4IP 0.005896 0.40595
355 3BRN SRO 0.04458 0.40589
356 4KNB 1RU 0.00001765 0.40588
357 4FFG LBS 0.03754 0.40565
358 3TM0 ANP 0.002875 0.40548
359 3OCP CMP 0.03249 0.40548
360 4BBE 3O4 0.0000008696 0.40532
361 2ZM3 575 0.00000388 0.40494
362 4BCM T7Z 0.000000561 0.40479
363 2ZM3 575 0.000003787 0.40454
364 1MQB ANP 0.000002503 0.40435
365 4KNB 1RU 0.00001062 0.40412
366 4KU7 PCG 0.02971 0.40396
367 3NOJ PYR 0.03106 0.40394
368 3NOJ PYR 0.03106 0.40394
369 3TM0 B31 0.002737 0.40387
370 4UXQ 0LI 0.000674 0.40361
371 3BZ3 YAM 0.00002721 0.4025
372 4BMB LAT 0.04571 0.40244
373 2ZTG A5A 0.02076 0.40185
374 2GC0 PAN 0.02077 0.40184
375 3KYG 5GP 5GP 0.01812 0.40158
376 1OPB RET 0.02524 0.40089
377 2DTJ THR 0.04082 0.40032
378 2DTJ THR 0.04082 0.40032
Feedback