Receptor
PDB id Resolution Class Description Source Keywords
4G55 1.69 Å NON-ENZYME: OTHER CLATHRIN TERMINAL DOMAIN COMPLEXED WITH PITSTOP 2 HOMO SAPIENS BETA-PROPELLER ENDOCYTOSIS
Ref.: ROLE OF THE CLATHRIN TERMINAL DOMAIN IN REGULATING PIT DYNAMICS REVEALED BY SMALL MOLECULE INHIBITION. CELL(CAMBRIDGE,MASS.) V. 146 471 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ACT A:404;
A:405;
A:406;
A:407;
A:417;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
submit data
59.044 C2 H3 O2 CC(=O...
DMS A:401;
A:402;
A:403;
A:415;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
78.133 C2 H6 O S CS(=O...
EDO A:408;
A:409;
A:412;
A:413;
A:414;
A:416;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
PEG A:410;
A:411;
Invalid;
Invalid;
none;
none;
submit data
106.12 C4 H10 O3 C(COC...
VH2 A:418;
Valid;
none;
submit data
475.379 C20 H15 Br N2 O3 S2 c1ccc...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1UTC 2.3 Å NON-ENZYME: OTHER CLATHRIN TERMINAL DOMAIN COMPLEXED WITH TLPWDLWTT BOS TAURUS ENDOCYTOSIS CLATHRIN CYTOSKELETON
Ref.: TWO DISTINCT INTERACTION MOTIFS IN AMPHIPHYSIN BIND TWO INDEPENDENT SITES ON THE CLATHRIN TERMINAL DOMAIN BETA-PROPELLER NAT.STRUCT.MOL.BIOL. V. 11 242 2004
Members (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 5M5S - GLU THR LEU LEU ASP LEU ASP PHE ASP PRO n/a n/a
2 5M5R - CYS GLY ASP LEU LEU ASN LEU ASP LEU GLY n/a n/a
3 5M5T - GLU THR LEU LEU ASP LEU ASP PHE LEU GLU n/a n/a
4 5M5V - SER PRO ARG LEU PRO LEU LEU GLU SER n/a n/a
5 2XZG - VH1 C19 H13 N2 O5 S c1cc2cc(cc....
6 4G55 - VH2 C20 H15 Br N2 O3 S2 c1ccc2c(c1....
7 5M5U - SER ASP ILE LEU PHE PRO ALA ASP SER n/a n/a
8 1UTC Kd = 28 uM THR LEU PRO TRP ASP LEU TRP THR THR n/a n/a
70% Homology Family (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 5M5S - GLU THR LEU LEU ASP LEU ASP PHE ASP PRO n/a n/a
2 5M5R - CYS GLY ASP LEU LEU ASN LEU ASP LEU GLY n/a n/a
3 5M5T - GLU THR LEU LEU ASP LEU ASP PHE LEU GLU n/a n/a
4 5M5V - SER PRO ARG LEU PRO LEU LEU GLU SER n/a n/a
5 2XZG - VH1 C19 H13 N2 O5 S c1cc2cc(cc....
6 4G55 - VH2 C20 H15 Br N2 O3 S2 c1ccc2c(c1....
7 5M5U - SER ASP ILE LEU PHE PRO ALA ASP SER n/a n/a
8 1UTC Kd = 28 uM THR LEU PRO TRP ASP LEU TRP THR THR n/a n/a
50% Homology Family (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 5M5S - GLU THR LEU LEU ASP LEU ASP PHE ASP PRO n/a n/a
2 5M5R - CYS GLY ASP LEU LEU ASN LEU ASP LEU GLY n/a n/a
3 5M5T - GLU THR LEU LEU ASP LEU ASP PHE LEU GLU n/a n/a
4 5M5V - SER PRO ARG LEU PRO LEU LEU GLU SER n/a n/a
5 2XZG - VH1 C19 H13 N2 O5 S c1cc2cc(cc....
6 4G55 - VH2 C20 H15 Br N2 O3 S2 c1ccc2c(c1....
7 5M5U - SER ASP ILE LEU PHE PRO ALA ASP SER n/a n/a
8 1UTC Kd = 28 uM THR LEU PRO TRP ASP LEU TRP THR THR n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: VH2; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 VH2 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
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