Receptor
PDB id Resolution Class Description Source Keywords
4FL3 1.9 Å EC: 2.7.10.2 STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THE SYK ACTIV SWITCH HOMO SAPIENS TRANSFERASE PROTEIN KINASE
Ref.: STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THE ACTIVATION SWITCH. J.MOL.BIOL. V. 425 309 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ANP A:701;
Valid;
none;
Kd = 150 uM
506.196 C10 H17 N6 O12 P3 c1nc(...
MG A:702;
Part of Protein;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4FL3 1.9 Å EC: 2.7.10.2 STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THE SYK ACTIV SWITCH HOMO SAPIENS TRANSFERASE PROTEIN KINASE
Ref.: STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THE ACTIVATION SWITCH. J.MOL.BIOL. V. 425 309 2013
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 35 families.
1 4FL3 Kd = 150 uM ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 4FL2 Kd = 220 uM ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 20 families.
1 4FL3 Kd = 150 uM ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 4FL2 Kd = 220 uM ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 4FL3 Kd = 150 uM ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 4FL2 Kd = 220 uM ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ANP; Similar ligands found: 358
No: Ligand ECFP6 Tc MDL keys Tc
1 ANP 1 1
2 A2D 0.810811 0.945205
3 B4P 0.802632 0.945205
4 ADP 0.802632 0.972222
5 AP5 0.802632 0.945205
6 BA3 0.789474 0.945205
7 AU1 0.782051 1
8 ATP 0.772152 0.972222
9 AN2 0.769231 0.986111
10 AQP 0.7625 0.972222
11 5FA 0.7625 0.972222
12 M33 0.759494 0.932432
13 MAP 0.752941 0.972973
14 ACP 0.75 0.945946
15 APR 0.740741 0.945205
16 AR6 0.740741 0.945205
17 ACQ 0.73494 0.945946
18 AD9 0.731707 0.945946
19 SAP 0.731707 0.921053
20 AGS 0.731707 0.921053
21 AMP 0.723684 0.944444
22 A 0.723684 0.944444
23 ATF 0.717647 0.933333
24 ADX 0.716049 0.851852
25 CA0 0.716049 0.92
26 50T 0.707317 0.932432
27 PRX 0.698795 0.87013
28 ABM 0.696203 0.893333
29 AMP MG 0.683544 0.868421
30 AP2 0.679012 0.933333
31 A12 0.679012 0.933333
32 APC 0.678571 0.933333
33 TAT 0.674419 0.933333
34 A22 0.674157 0.958904
35 SRA 0.670886 0.894737
36 SRP 0.670455 0.883117
37 5AL 0.666667 0.906667
38 ADQ 0.659341 0.92
39 A1R 0.659341 0.884615
40 ADP MG 0.654762 0.881579
41 3OD 0.648936 0.92
42 BIS 0.648936 0.909091
43 5SV 0.648352 0.82716
44 BEF ADP 0.647059 0.858974
45 ADP BEF 0.647059 0.858974
46 OAD 0.645161 0.92
47 25L 0.642105 0.958904
48 AMO 0.641304 0.907895
49 G5P 0.636364 0.897436
50 DLL 0.634409 0.906667
51 AHX 0.634409 0.897436
52 00A 0.634409 0.860759
53 ANP MG 0.633333 0.921053
54 ADV 0.632184 0.907895
55 ADP PO3 0.632184 0.917808
56 RBY 0.632184 0.907895
57 NB8 0.631579 0.897436
58 25A 0.630435 0.945205
59 8QN 0.630435 0.906667
60 OOB 0.630435 0.906667
61 G3A 0.626263 0.897436
62 ATP MG 0.625 0.881579
63 4AD 0.623656 0.896104
64 PAJ 0.623656 0.8625
65 LAD 0.621053 0.839506
66 1ZZ 0.614583 0.819277
67 TXA 0.614583 0.907895
68 ME8 0.614583 0.819277
69 GTA 0.613861 0.864198
70 3UK 0.610526 0.894737
71 SON 0.604651 0.907895
72 ADP ALF 0.604396 0.848101
73 ALF ADP 0.604396 0.848101
74 WAQ 0.604167 0.860759
75 PR8 0.604167 0.829268
76 4UV 0.6 0.871795
77 GAP 0.6 0.87013
78 FYA 0.597938 0.881579
79 PTJ 0.597938 0.873418
80 ADP VO4 0.597826 0.906667
81 VO4 ADP 0.597826 0.906667
82 UP5 0.596154 0.896104
83 YAP 0.59596 0.871795
84 FA5 0.59596 0.883117
85 PAP 0.595506 0.958333
86 A4P 0.59434 0.823529
87 XAH 0.59 0.841463
88 4UU 0.588235 0.871795
89 AFH 0.588235 0.8625
90 9SN 0.585859 0.85
91 2A5 0.58427 0.894737
92 T5A 0.583333 0.821429
93 NAI 0.580952 0.884615
94 ITT 0.579545 0.917808
95 ATR 0.577778 0.944444
96 OMR 0.575472 0.831325
97 5AS 0.574713 0.781609
98 YLP 0.571429 0.8
99 48N 0.571429 0.873418
100 AP0 0.570093 0.873418
101 4TC 0.570093 0.873418
102 7D3 0.569767 0.881579
103 ADJ 0.568807 0.831325
104 GNP 0.568421 0.922078
105 DAL AMP 0.568421 0.881579
106 NXX 0.566038 0.907895
107 TXD 0.566038 0.884615
108 NAX 0.566038 0.851852
109 4UW 0.566038 0.839506
110 6V0 0.566038 0.873418
111 DND 0.566038 0.907895
112 XYA 0.565789 0.821918
113 ADN 0.565789 0.821918
114 RAB 0.565789 0.821918
115 AOC 0.564706 0.8
116 7D4 0.561798 0.881579
117 ADP BMA 0.561224 0.894737
118 TXE 0.560748 0.884615
119 TYM 0.560748 0.883117
120 YLB 0.555556 0.8
121 YLC 0.555556 0.819277
122 139 0.554545 0.851852
123 5N5 0.551282 0.797297
124 JB6 0.55 0.860759
125 LAQ 0.54717 0.819277
126 MYR AMP 0.544554 0.797619
127 A4D 0.544304 0.797297
128 5CD 0.544304 0.783784
129 7MD 0.542857 0.864198
130 6AD 0.542553 0.886076
131 A2R 0.541667 0.958904
132 UPA 0.541284 0.884615
133 YLA 0.540541 0.8
134 A A 0.54 0.918919
135 COD 0.539823 0.793103
136 BTX 0.539823 0.821429
137 G5A 0.537634 0.781609
138 CNA 0.535714 0.907895
139 AYB 0.535714 0.790698
140 3DH 0.535714 0.753247
141 BT5 0.535088 0.811765
142 ATP A A A 0.533981 0.905405
143 IOT 0.531532 0.811765
144 MTA 0.53012 0.753247
145 3AM 0.529412 0.90411
146 A3P 0.52809 0.944444
147 NAD 0.526316 0.906667
148 PPS 0.526316 0.851852
149 EP4 0.52439 0.734177
150 7D5 0.52381 0.855263
151 AMP DBH 0.52381 0.87013
152 J7C 0.522727 0.75
153 A5A 0.520833 0.809524
154 EAD 0.520661 0.851852
155 TSB 0.520408 0.821429
156 AHZ 0.518519 0.797619
157 M2T 0.518072 0.716049
158 DTA 0.518072 0.766234
159 A3D 0.517241 0.894737
160 6RE 0.517241 0.740741
161 YLY 0.516949 0.790698
162 SSA 0.515464 0.802326
163 NA7 0.514852 0.933333
164 TYR AMP 0.514286 0.858974
165 AR6 AR6 0.514019 0.893333
166 7MC 0.513514 0.843373
167 A2P 0.511111 0.930556
168 52H 0.510204 0.781609
169 VMS 0.510204 0.790698
170 54H 0.510204 0.790698
171 TAD 0.509259 0.8625
172 NAQ 0.508333 0.85
173 A3N 0.505618 0.766234
174 AV2 0.505155 0.893333
175 5CA 0.50505 0.802326
176 53H 0.50505 0.781609
177 ARU 0.504951 0.839506
178 ARG AMP 0.504587 0.809524
179 ZID 0.504132 0.894737
180 P1H 0.504 0.831325
181 3AT 0.5 0.945205
182 NAE 0.5 0.871795
183 AVV 0.5 0.873418
184 P5A 0.495146 0.747253
185 DSZ 0.49505 0.802326
186 LSS 0.49505 0.764045
187 NSS 0.49505 0.802326
188 N0B 0.491803 0.8
189 AF3 ADP 3PG 0.491071 0.817073
190 LA8 ALF 3PG 0.491071 0.817073
191 ALF ADP 3PG 0.491071 0.817073
192 NVA LMS 0.490196 0.764045
193 DAT 0.489362 0.881579
194 IMO 0.488889 0.90411
195 ZAS 0.488636 0.792208
196 FDA 0.488372 0.813953
197 NAJ PZO 0.487395 0.85
198 4TA 0.487179 0.788235
199 LPA AMP 0.486486 0.797619
200 LEU LMS 0.485437 0.764045
201 DTP 0.484536 0.881579
202 V3L 0.484536 0.945205
203 GJV 0.483516 0.731707
204 S4M 0.483516 0.651685
205 DZD 0.483051 0.8625
206 2AM 0.482759 0.917808
207 5AD 0.481013 0.726027
208 KAA 0.480769 0.755556
209 GSU 0.480769 0.781609
210 NDE 0.480315 0.907895
211 M24 0.479339 0.851852
212 MAO 0.478261 0.761905
213 DSH 0.477778 0.707317
214 NEC 0.477778 0.727273
215 FAD 0.477273 0.831325
216 FAS 0.477273 0.831325
217 RGT 0.476636 0.933333
218 0WD 0.474576 0.897436
219 G A A A 0.474576 0.85
220 FNK 0.474074 0.786517
221 5X8 0.473684 0.74359
222 6FA 0.473282 0.821429
223 FB0 0.472868 0.786517
224 NDC 0.472868 0.85
225 YSA 0.472222 0.781609
226 7DD 0.468085 0.958333
227 OVE 0.466667 0.881579
228 NAD IBO 0.466102 0.848101
229 MHZ 0.463158 0.701149
230 A3G 0.461538 0.779221
231 6C6 0.459184 0.858974
232 U A G G 0.458333 0.860759
233 SFG 0.458333 0.730769
234 7D7 0.45679 0.723684
235 128 0.45614 0.8
236 SFD 0.455224 0.736842
237 DDS 0.454545 0.855263
238 GDP 0.454545 0.896104
239 6IA 0.454545 0.817073
240 NJP 0.453782 0.921053
241 ODP 0.453782 0.886076
242 7DT 0.453608 0.958333
243 A7D 0.452632 0.75641
244 Z5A 0.452381 0.802326
245 WSA 0.452174 0.790698
246 7C5 0.45045 0.797468
247 FAY 0.449275 0.841463
248 NDP 0.449153 0.897436
249 A5D 0.44898 0.766234
250 SA8 0.44898 0.690476
251 NAJ PYZ 0.448 0.851852
252 71V 0.446809 0.884615
253 GGZ 0.446602 0.804878
254 RFL 0.446043 0.802326
255 2SA 0.445545 0.907895
256 AMP NAD 0.444444 0.858974
257 GP3 0.444444 0.897436
258 SAI 0.444444 0.716049
259 SAH 0.444444 0.725
260 A A A 0.443396 0.881579
261 PO4 PO4 A A A A PO4 0.443396 0.878378
262 4YB 0.442478 0.764045
263 GTP 0.441176 0.896104
264 SMM 0.441176 0.670455
265 S7M 0.441176 0.674419
266 Y3J 0.440476 0.706667
267 SAM 0.44 0.674419
268 649 0.439655 0.747253
269 12D 0.438596 0.809524
270 A3S 0.4375 0.789474
271 NPW 0.436975 0.864198
272 GCP 0.436893 0.873418
273 AAT 0.435644 0.690476
274 EEM 0.435644 0.674419
275 GNH 0.435644 0.909091
276 DCA 0.435484 0.804598
277 ETB 0.435484 0.813953
278 N6P 0.433962 0.890411
279 TXP 0.433333 0.897436
280 NZQ 0.433333 0.886076
281 PGS 0.43299 0.860759
282 APU 0.432203 0.871795
283 PUA 0.432 0.8625
284 62F 0.431655 0.841463
285 F2N 0.431507 0.795455
286 DA 0.430108 0.855263
287 D5M 0.430108 0.855263
288 J7V 0.429688 0.813953
289 NIA 0.428571 0.848101
290 6K6 0.428571 0.905405
291 A3T 0.428571 0.8
292 0T1 0.428571 0.804598
293 COA 0.428571 0.804598
294 P5F 0.427586 0.804598
295 AAM 0.425532 0.944444
296 0UM 0.424528 0.682353
297 G1R 0.423077 0.884615
298 AMZ 0.422222 0.891892
299 C2R 0.422222 0.88
300 A U 0.420168 0.848101
301 IDP 0.42 0.894737
302 GSP 0.419048 0.851852
303 COS 0.418605 0.786517
304 CAO 0.418605 0.777778
305 AMX 0.418605 0.813953
306 30N 0.418605 0.736842
307 DG1 0.418605 0.897436
308 1DG 0.418605 0.897436
309 TM1 0.418182 0.797619
310 A6D 0.416667 0.746988
311 K15 0.416667 0.666667
312 V1N 0.415929 0.893333
313 SCO 0.415385 0.804598
314 CMX 0.415385 0.804598
315 GEK 0.415094 0.719512
316 NHD 0.414634 0.881579
317 XNP 0.414634 0.851852
318 AIR 0.413793 0.876712
319 COK 0.413534 0.786517
320 G2R 0.412844 0.8625
321 FCX 0.412214 0.777778
322 FAM 0.412214 0.786517
323 ACO 0.412214 0.777778
324 NAP 0.410853 0.92
325 CNV FAD 0.409722 0.775281
326 FA9 0.409396 0.843373
327 SXZ 0.409091 0.694118
328 HAX 0.409091 0.806818
329 PLP AAD 0.408 0.744444
330 TAP 0.407692 0.884615
331 2MC 0.407407 0.752688
332 62X 0.407407 0.651685
333 GKE 0.40708 0.8625
334 GDD 0.40708 0.8625
335 GDC 0.40708 0.8625
336 FYN 0.406015 0.804598
337 3KK 0.406015 0.786517
338 U G A 0.405797 0.819277
339 NA0 0.40458 0.907895
340 101 0.404255 0.855263
341 G 0.40404 0.883117
342 5GP 0.40404 0.883117
343 MGP 0.403846 0.8625
344 MCD 0.402985 0.786517
345 OXK 0.402985 0.786517
346 CA6 0.402985 0.714286
347 SOP 0.402985 0.786517
348 3AD 0.402299 0.783784
349 S8M 0.401869 0.78481
350 YE1 0.40146 0.795455
351 1VU 0.4 0.777778
352 2VA 0.4 0.779221
353 CMC 0.4 0.786517
354 7RP 0.4 0.902778
355 GMV 0.4 0.873418
356 6G0 0.4 0.8625
357 CO6 0.4 0.786517
358 NMX 0.4 0.782609
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4FL3; Ligand: ANP; Similar sites found: 335
This union binding pocket(no: 1) in the query (biounit: 4fl3.bio1) has 25 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3WVR AMP 0.00119 0.40929 1.11857
2 4AXD ANP 0.000003189 0.56491 1.31579
3 4ANW O92 0.0002232 0.47589 1.41732
4 3UDZ ADP 0.000001001 0.54277 1.41988
5 4U98 ACP 0.001625 0.4397 1.54185
6 1YKJ FAD 0.02573 0.40955 1.77665
7 3VPD ANP 0.003416 0.41039 1.77936
8 5I35 ANP 0.000001003 0.58535 1.78117
9 5JLB SAH 0.00332 0.4256 1.79211
10 2VQD AP2 0.0009036 0.43002 1.93966
11 2DUR MAN MAN 0.01793 0.41147 1.97628
12 4OCV ANP 0.0003331 0.44583 2.20472
13 2YY7 NAD 0.00935 0.40511 2.24359
14 2IO8 ADP 0.0002799 0.45972 2.26171
15 4R78 AMP 0.000182 0.50681 2.26537
16 3GD4 NAD 0.02098 0.41946 2.34834
17 3GD4 FAD 0.01431 0.41912 2.34834
18 4PU5 ANP 0.002551 0.4175 2.42826
19 4CC6 L5Y 0.001853 0.45646 2.51572
20 3WO0 ALA 0.00811 0.41359 2.55319
21 1M0W ANP 0.0003644 0.42532 2.64766
22 5MRH Q9Z 0.003173 0.44478 2.67717
23 1GTE FAD 0.03662 0.40099 2.67717
24 3AKK ADP 0.0007221 0.4314 2.76923
25 4GYI ADP 0.0000258 0.53445 2.77078
26 4OAV ACP 0.00000001123 0.59819 2.83465
27 2VPQ ANP 0.002059 0.42141 2.88248
28 3B6R CRN 0.004317 0.4359 2.88714
29 1PK8 ATP 0.002408 0.42197 2.99213
30 5VZ0 ADP 0.00112 0.41478 2.99213
31 2PUL ACP 0.00001814 0.47573 3.02267
32 3V4S ATP 0.005002 0.40347 3.10078
33 4O1P ANP 0.00000001152 0.61029 3.14961
34 3DNT ATP 0.003714 0.41235 3.40909
35 3MBI HSX 0.009385 0.42119 3.48432
36 1IA9 ANP 0.00001692 0.51753 3.57143
37 1H82 GZZ 0.02696 0.40797 3.60169
38 4OCJ NDG 0.0008661 0.4568 3.77953
39 5JCA NDP 0.03481 0.40265 3.79747
40 5JCA FAD 0.01905 0.40265 3.79747
41 3TDV GDP 0.0000113 0.49829 3.92157
42 5KBE IPH 0.02492 0.40397 3.93013
43 3ETH ATP 0.002448 0.41643 3.94366
44 2R3A SAM 0.002863 0.4007 4
45 2HGS ADP 0.001214 0.43103 4.00844
46 2V58 LZJ 0.003957 0.43371 4.00891
47 3HAV ATP 0.005212 0.40928 4.01338
48 5ML3 DL3 0.01207 0.40588 4.02685
49 2FXD DR7 0.002372 0.42838 4.0404
50 3ZJX BOG 0.0001112 0.52937 4.15225
51 4ZS4 ATP 0.0000002232 0.59918 4.23453
52 5MW8 ATP 0.000003543 0.53731 4.24628
53 3OOI SAM 0.004972 0.40019 4.31034
54 5CPR 539 0.01519 0.41068 4.47761
55 4KU7 PCG 0.002401 0.44086 4.57516
56 3PDT ADP 0.0000006879 0.5274 4.72727
57 4LRJ ANP 0.000000526 0.54131 4.73373
58 3X01 AMP 0.001389 0.47001 4.83461
59 1OBD ATP 0.0008424 0.40581 4.90196
60 1TQP ATP 0.00001755 0.51043 4.96454
61 4OUC 5ID 0.0000008121 0.52549 5.04202
62 5W2I ADP 0.002583 0.41901 5.05837
63 5W2I I3P 0.002583 0.41901 5.05837
64 3W0O ADP 0.000725 0.45063 5.15759
65 3W0O HY0 0.000725 0.40179 5.15759
66 4XMF HSM 0.0001398 0.53601 5.43478
67 4OYA 1VE 0.01182 0.42504 5.82677
68 2GQR ADP 0.0002906 0.4341 5.90717
69 1GSA ADP 0.0001207 0.47307 6.01266
70 5JSQ 6MS 0.01443 0.40372 6.01852
71 1N62 FAD 0.01614 0.40223 6.0241
72 3K5I ADP 0.001565 0.42105 6.20347
73 3K5I AIR 0.007376 0.40962 6.20347
74 4IX4 ADP 0.00004503 0.48371 6.28571
75 2GQS ADP 0.0002434 0.43883 6.32911
76 4NJH 2K8 0.008782 0.40631 6.52174
77 1T36 ADP 0.001785 0.43071 7.06806
78 4CYI ATP 0.000003851 0.52596 7.07763
79 3CTY FAD 0.01812 0.40536 7.21003
80 2CUL FAD 0.01269 0.40385 7.32759
81 2V6O FAD 0.02051 0.41941 7.38255
82 5TDF ADP 0.004145 0.403 7.40741
83 4AZW ATP 0.00136 0.42352 7.431
84 3VPC ADP 0.0002243 0.45971 7.44681
85 2PYW ADP 0.00001878 0.49869 7.85714
86 5K2M ADP 0.001813 0.4255 8.05861
87 5IQD RIO 0.0007797 0.45883 8.19672
88 5IQD GNP 0.0007306 0.45883 8.19672
89 1I7L ATP 0.002237 0.42164 8.41424
90 2PZI AXX 0.00001496 0.5457 8.81057
91 2BKK ADP 0.0006109 0.41723 8.87574
92 4RDL FUC GAL NDG FUC 0.01513 0.41739 9.09091
93 4Z4P SAH 0.007599 0.40925 9.63855
94 4FHD 0TT 0.008721 0.40644 9.78261
95 4FHD EEM 0.008721 0.40644 9.78261
96 3Q60 ATP 0.000001125 0.52978 9.97305
97 4LO2 GAL BGC 0.005821 0.42744 10.2041
98 3KA2 2NC 0.01235 0.41629 10.3448
99 5C4L 4XR 0.00009392 0.49066 10.5919
100 5C4L SIS 0.0002061 0.47584 10.5919
101 5CKW ANP 0.00004555 0.4507 11.0865
102 5MY8 RXZ 0.0000003297 0.58575 11.3386
103 4Q5H ANP 0.000007738 0.53853 11.8421
104 4CRL C1I 0.000002185 0.46699 12.069
105 4IJP 1EH 0.0000001097 0.5898 12.2905
106 1ZP9 ATP 0.000004353 0.49397 12.7907
107 1ZTH ADP 0.00000166 0.49139 12.7907
108 3RE4 TO1 0.000003198 0.48034 13.1783
109 4FE2 ADP 0.0005614 0.41681 13.3333
110 4XBT 3ZQ 0.009006 0.41351 13.5484
111 2AQX ATP 0.005003 0.40347 14.1869
112 4YZC STU 0.00000006919 0.63691 14.3307
113 5GZ9 ANP 0.00000001189 0.64103 14.4262
114 4UAL 3FV 0.0000001277 0.56802 14.4882
115 4WW7 AMP 0.00001288 0.51144 14.5594
116 1OUK 084 0.000006767 0.60147 15.0273
117 1Q8Y ADP 0.00000000129 0.66854 15.1181
118 1Q8Y ADE 0.000002057 0.48689 15.1181
119 3OFM 4B0 0.000001178 0.50566 15.1429
120 4LOO SB4 0.00003499 0.47489 15.2355
121 2WU6 DKI 0.000000006445 0.65218 15.2756
122 3GC8 B45 0.00001155 0.51341 15.4054
123 3PVW QRX 0.0000002062 0.59689 15.4331
124 5X8I SQZ 0.00000002109 0.65235 15.6069
125 4QTB 38Z 0.000000002548 0.68368 15.7895
126 4WNK 453 0.000000003022 0.6831 15.8863
127 3UIM ANP 0.0000002771 0.55846 15.9509
128 4Y0X ADP 0.0000001864 0.54977 16
129 4JR7 GNP 0.0000000735 0.57942 16.0428
130 3VPB ADP 0.00009285 0.48192 16.0714
131 4XYM A12 0.0004899 0.43611 16.087
132 5EKO N17 0.0004104 0.45078 16.1725
133 5DMZ ADP 0.000000004904 0.68046 16.4384
134 4L9I 8PR 0.0000001356 0.62477 16.8651
135 4F9C 0SX 0.0000003266 0.54769 16.8975
136 1RZ1 NAD 0.01476 0.41468 17.3913
137 4Y85 499 0.0000003039 0.54566 17.4699
138 2F2U M77 0.0000007804 0.61558 17.6617
139 1CM8 ANP 0.00002978 0.47574 17.7112
140 3V8S 0HD 0.0000001019 0.56289 17.8049
141 4WHZ 3NL 0.000001481 0.41641 18.1818
142 3TTI KBI 0.00000001419 0.58132 18.319
143 3H9R TAK 0.00000005788 0.52341 18.4848
144 5AX9 4KT 0.00000008086 0.57663 19.1558
145 4UX9 ANP 0.000000004475 0.66407 19.2308
146 4IZY 1J2 0.00000009649 0.59191 19.2412
147 3PTG 932 0.000002517 0.48589 19.2837
148 3E7O 35F 0.00006129 0.42596 19.4444
149 5M06 ADP 0.0000001159 0.63669 19.5652
150 5BWD FUM 0.01814 0.41315 20
151 4H3Q ANP 0.000000001306 0.68125 20.1657
152 4H3P ANP 0.0000000005006 0.66182 20.1657
153 5BVE 4VG 0.0000007376 0.62038 20.2216
154 5T8O 76Z 0.0000009244 0.56559 20.3438
155 3PE2 E1B 0.0000008926 0.60031 20.4748
156 4NST ADP 0.000000202 0.56441 20.5128
157 3LQV ADE 0.01307 0.41341 20.5128
158 5LXC 7AA 0.00000001526 0.58813 20.5882
159 3GNI ATP 0.0000000218 0.63482 20.8226
160 5BYZ 4WE 0.00000004064 0.63664 20.977
161 5AWM ANP 0.0000009223 0.61204 21.066
162 1VJY 460 0.000000007742 0.67025 21.4521
163 3IGO ANP 0.00000004198 0.61508 21.8107
164 3SXF BK5 0.00000002898 0.64957 21.9008
165 4FG8 ATP 0.000000005909 0.6414 21.9048
166 2QLU ADE 0.000001053 0.63633 22.293
167 5TA6 79D 0.00000004252 0.56155 22.905
168 4DC2 ADE 0.00000004151 0.48129 22.9798
169 2F57 23D 0.00000001609 0.5838 23.6593
170 2X4Z X4Z 0.000000007561 0.67521 24.3243
171 3FHR P4O 0.000003552 0.54698 24.4048
172 3HZT J60 0.0000111 0.46895 24.6253
173 5LI1 ANP 0.0000000008347 0.686 25.1412
174 3M2W L8I 0.00000003242 0.56758 25.4181
175 5LI9 ACP 0.00000001168 0.65484 25.4286
176 3MVH WFE 0.00000002305 0.64497 25.4386
177 2R5T ANP 0.00000001025 0.6406 25.4692
178 2B9H ADP 0.00000008848 0.58608 25.4958
179 2B9F ADP 0.00000008927 0.57612 25.4958
180 2B9I ADP 0.0000001541 0.56567 25.4958
181 2B9J ADP 0.0000001305 0.56244 25.4958
182 3C0G 3AM 0.0000000682 0.65696 25.641
183 3ORK AGS 0.000000004096 0.66652 25.7235
184 5UKL SIX 0.00000002509 0.63845 25.8065
185 3TXO 07U 0.0000004916 0.53402 26.0623
186 3VHE 42Q 0.0000004136 0.5908 26.1838
187 5IH9 6BF 0.00000003862 0.64614 26.2687
188 2JDR L20 0.00000002634 0.42461 26.3158
189 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.00000002634 0.42461 26.3158
190 4Y8D 49J 0.0000006154 0.58732 27.0588
191 2WEL K88 0.0000006861 0.47074 27.2171
192 4KS7 X4Z 0.00000001985 0.63171 27.3973
193 2VZ6 FEF 0.00000001128 0.57862 27.476
194 4BFM ANP 0.00000000008903 0.71502 27.5449
195 2V7O DRN 0.00000004734 0.53695 27.6786
196 3TKI S25 0.00000001941 0.68502 28.1734
197 2HY0 306 0.00000009507 0.65011 28.2609
198 4XH0 ADP 0.0000006459 0.64691 28.2878
199 2ZV2 609 0.00000002155 0.69149 28.5235
200 4YLL 4E3 0.00000001985 0.6317 28.5319
201 4IDT T28 0.00000003632 0.5831 28.6517
202 3DLS ADP 0.000001123 0.51981 28.6567
203 2PVN P63 0.00000001074 0.57162 28.6932
204 2RIO ADP 0.000000000395 0.65667 28.8018
205 2JLD AG1 0.00000000507 0.68058 28.8095
206 5LVP ATP 0.00000000487 0.59218 28.9389
207 4WB7 ATP 0.00000007775 0.49647 29.1358
208 4EUU BX7 0.0000002342 0.59453 29.1536
209 1ZY5 ANP 0.000001745 0.51505 29.3729
210 4U44 3D9 0.00000001361 0.60729 29.5181
211 3HMO STU 0.00000004248 0.57704 29.5322
212 2VN9 GVD 0.00000001087 0.55146 29.5681
213 2YAB AMP 0.000000009187 0.62439 29.6399
214 4G17 0VN 0.00001498 0.47719 29.697
215 3GC0 AMP 0.00000008902 0.55019 29.7872
216 4BHN BH9 0.0000001793 0.59589 29.9401
217 4I94 ANP 0.0000001441 0.55608 30
218 4OH4 ANP 0.00000003282 0.59619 30.03
219 5LPZ ADP 0.00000000174 0.70043 30.1205
220 4OTH DRN 0.0000000009621 0.68343 30.2053
221 5UIU 8CG 0.000000007179 0.66686 30.3406
222 4JDI ANP 0.0000000003089 0.69293 30.3468
223 2BPM 529 0.0000001855 0.44123 30.4207
224 4G31 0WH 0.00004092 0.42101 30.4348
225 4N70 2HX 0.0000000165 0.68223 30.4878
226 5EFQ ADP 0.0000001085 0.57512 30.5476
227 1PHK ATP 0.000000007956 0.62706 30.8725
228 4CFU 2WC 0.00000002904 0.58033 31.0231
229 4BTK DTQ 0.000001658 0.52412 31.1573
230 4BCQ TJF 0.000000465 0.51881 31.2292
231 4BCM T7Z 0.000002088 0.47701 31.2292
232 4BCN T9N 0.00000005688 0.66071 31.3333
233 2XK9 XK9 0.000000001733 0.70557 31.3665
234 2XMY CDK 0.0000001767 0.6529 31.5436
235 5LMK 6ZK 0.0000005541 0.52433 31.6498
236 3KMW ATP 0.0001386 0.45046 31.7343
237 5VCV 1N1 0.00000002108 0.60206 31.8328
238 3CY2 MB9 0.0000000717 0.59344 31.8471
239 1U5R ATP 0.00000001049 0.60208 31.8966
240 5DBX ANP 0.000000009829 0.57646 32.0122
241 3ZRM ZRM 0.000001527 0.52875 32.345
242 4NM5 ADP 0.0000003553 0.56557 32.3607
243 1XJD STU 0.0000002364 0.59809 32.4638
244 3KN5 ANP 0.000004886 0.48827 32.6154
245 2A19 ANP 0.00000001583 0.69801 32.7465
246 5N87 N66 0.0000001175 0.62484 32.9073
247 4WB6 ATP 0.000000004194 0.66895 33.1429
248 4C2W ANP 0.00000001065 0.57031 33.3333
249 5JZJ AN2 0.000000000101 0.6771 33.67
250 4C2V YJA 0.0000001477 0.61012 33.6842
251 5EYK 5U5 0.00000001325 0.57928 33.6957
252 5LPB ADP 0.00000001019 0.5743 33.7838
253 5DH3 5BS 0.0000002098 0.59299 33.9683
254 4NFN 2KC 0.000006098 0.49523 33.9806
255 1V0O INR 0.00000009716 0.58488 34.0278
256 3F7Z 34O 0.00000002871 0.59587 34.2857
257 1O9U ADZ 0.0000007301 0.40948 34.2857
258 4NW6 2NS 0.00000001017 0.66508 34.3653
259 3AQV TAK 0.00006419 0.46228 34.4203
260 2GU8 796 0.00000003398 0.67658 34.4214
261 5DEY 59T 0.0000001632 0.42268 34.6801
262 4I6H 1C8 0.000000349 0.59826 34.7403
263 3SLS ANP 0.00000000001753 0.75592 34.8684
264 4X7Q 3YR 0.00000009293 0.62376 34.9359
265 3E8N ATP 0.000000001439 0.72532 35.4839
266 3E8N VRA 0.000000001439 0.49789 35.4839
267 4USF 6UI 0.000003266 0.54121 35.5263
268 4D2S DYK 0.0000002647 0.52653 35.5634
269 5A6N U7E 0.0000000109 0.6195 35.689
270 2Z7R STU 0.000000003455 0.66029 35.8255
271 5DRB 5FJ 0.0000005529 0.43358 36.0825
272 5HQ0 LZ9 0.0000000206 0.63586 36.0927
273 2YAK OSV 0.00000005468 0.62876 36.1404
274 4AU8 Z3R 0.000003878 0.48109 36.1486
275 4AUA 4AU 0.0000085 0.49702 36.1564
276 5UOX 8GY 0.0000002897 0.58012 36.1624
277 5CEO 50D 0.00000001763 0.60321 36.3333
278 1UNH IXM 0.00000011 0.54754 36.6438
279 3O0G 3O0 0.0000003454 0.54604 36.6438
280 2CSN CKI 0.0000000008645 0.69817 36.7003
281 5JGA 6KC 0.00000001279 0.54194 36.8254
282 5L8L ADP 0.000000003334 0.73096 36.8421
283 5G1X ADP 0.0000000008167 0.72552 36.8421
284 2WEI VGG 0.0000006913 0.52163 36.9338
285 3C1X CKK 0.0007275 0.43841 36.9973
286 5LXM ADP 0.000000001324 0.71599 37.1025
287 5HVJ ANP 0.0000007642 0.64107 37.1429
288 5W4W 9WG 0.000005522 0.54407 37.4622
289 4KBA 1QM 0.00001372 0.47188 37.4622
290 4WNP 3RJ 0.000000001561 0.73492 37.6307
291 3ALN ANP 0.0000000007548 0.67721 37.9205
292 2QCS ANP 0.000000002095 0.68179 38
293 2J7T 274 0.00002745 0.51207 38.0795
294 5KO1 6UY 0.00000006116 0.64047 38.1625
295 3DAK ANP 0.000000004995 0.60107 38.2759
296 4A4X JUP 0.00000002551 0.63555 38.3513
297 5EW9 5VC 0.00000001079 0.74003 38.3764
298 3E5A VX6 0.00000003641 0.58335 38.806
299 4M69 ANP 0.000000001988 0.66004 38.8693
300 4L3L 5FI 0.000005179 0.54337 39.1447
301 4P5Z Q7M 0.0000001728 0.47745 39.6122
302 1RE8 BD2 0.0000006219 0.60744 39.7143
303 3IDB ANP 0.0000003089 0.58173 39.7143
304 2WQN ADP 0.000000004969 0.71102 40
305 3FHI ANP 0.000000004886 0.66612 40
306 4QMN DB8 0.0000004159 0.48117 40
307 4ASE AV9 0.000001729 0.55975 40.2266
308 3GGF GVD 0.000000007254 0.59632 40.5316
309 3GQI ACP 0.000000001241 0.64808 40.7975
310 5HES 032 0.0000003223 0.57819 41.6938
311 4XV1 904 0.0000001301 0.61892 41.7808
312 4U0I 0LI 0.00007158 0.49578 42.8571
313 4BKJ STI 0.00372 0.41395 42.8571
314 5UR1 YY9 0.0000001188 0.63531 43.4084
315 3PP0 03Q 0.000001622 0.51196 43.787
316 4CQE CQE 0.00004266 0.48976 43.8849
317 5EOB 5QQ 0.000000105 0.65253 43.8871
318 4CLI 5P8 0.000000003267 0.7074 44.3425
319 5JFS 6K0 0.00000004176 0.65224 44.8052
320 4AG8 AXI 0.000001655 0.45482 44.9367
321 4FF8 14S 0.0003359 0.41905 45.2012
322 2PVF ACP 0.0000000005024 0.6504 45.2096
323 3KRL KRL 0.000001145 0.55524 45.9701
324 4K33 ACP 0.0000000003632 0.67952 46.4615
325 5HCY 60D 0.000000000684 0.73805 46.5257
326 4YZN 4K5 0.0000000009901 0.66792 46.6899
327 5NKB 8ZT 0.000000112 0.46543 46.732
328 5JKG 6LF 0.0000009054 0.5892 46.9453
329 3BU5 ATP 0.000000001078 0.64957 47.7124
330 3PLS ANP 0.0000000004769 0.65183 47.9866
331 4AT3 LTI 0.0000008681 0.49899 48.1605
332 3EKK GS2 0.000000001761 0.53954 48.5342
333 4YMJ 4EJ 0.0000001041 0.68705 48.6842
334 3RI1 3RH 0.000000004379 0.66815 48.8818
335 2XVD AS6 0.00000002549 0.64066 49.6689
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