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Receptor
PDB id Resolution Class Description Source Keywords
4EYM 2.35 Å EC: 2.7.11.24 MAPK13 COMPLEX WITH INHIBITOR HOMO SAPIENS P38 FAMILY KINASE MAP KINASE TRANSFERASE-TRANSFERASE INHIBCOMPLEX
Ref.: IL-13-INDUCED AIRWAY MUCUS PRODUCTION IS ATTENUATED MAPK13 INHIBITION. J.CLIN.INVEST. V. 122 4555 2012
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
0RX A:401;
Valid;
none;
submit data
376.409 C21 H20 N4 O3 c1cc(...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5EKO 2 Å EC: 2.7.11.24 CRYSTAL STRUCTURE OF MAPK13 COMPLEX WITH INHIBITOR HOMO SAPIENS KINASE TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: FIRST COMPREHENSIVE STRUCTURAL AND BIOPHYSICAL ANAL MAPK13 INHIBITORS TARGETING DFG-IN AND DFG-OUT BIND MODES. BIOCHIM.BIOPHYS.ACTA V.1860 2335 2016
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 16 families.
1 4EYM - 0RX C21 H20 N4 O3 c1cc(ccc1N....
2 5EKO ic50 = 15785 nM N17 C22 H18 N4 O2 Cc1cn(cn1)....
3 4EYJ - N61 C20 H23 N5 O2 CC(C)(C)c1....
70% Homology Family (159)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 10 families.
1 3GCV Kd = 74 nM SS6 C29 H30 N8 O Cc1cccc(c1....
2 3L8S Kd = 99 nM BFF C20 H24 Br F2 N5 O3 S c1c(cc(c(c....
3 3RIN ic50 = 1.3 nM I2O C23 H24 N2 O2 Cc1ccc(cc1....
4 5N65 - 8OT C20 H18 N4 S c1ccc(cc1)....
5 4FA2 - SB0 C20 H21 F N4 O2 COc1nccc(n....
6 2GHM - LIC C24 H28 Cl N5 O3 C[C@@H](C(....
7 1W84 ic50 = 35 uM L12 C15 H14 N2 c1ccc2c(c1....
8 4EH5 - IRG C17 H16 N4 c1ccc(cc1)....
9 2BAK Kd = 37 nM AQZ C32 H37 N7 O4 Cc1ccc(cc1....
10 3HV6 ic50 = 5500 nM R39 C27 H35 N5 O3 Cc1ccc(cc1....
11 3HP2 - P36 C19 H16 Br N O2 c1ccc(cc1)....
12 1WBO ic50 = 1 mM 2CH C6 H5 Cl O c1ccc(c(c1....
13 4KIQ ic50 = 23 nM 1RA C23 H23 N3 O4 CCOC(=O)n1....
14 3GC7 ic50 = 0.4 nM B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
15 4EH6 - IRG C17 H16 N4 c1ccc(cc1)....
16 5MTX Kd = 17.7 nM FJI C34 H31 F N4 O5 c1ccc(cc1)....
17 2ZB0 Ki = 0.24 uM GK3 C24 H18 N4 O2 Cc1ccc(cc1....
18 2GTM ic50 = 542 nM LID C19 H15 Cl F2 N6 CCn1c2c(cn....
19 5N66 - B96 C31 H37 N5 O3 Cc1ccc(cc1....
20 2YIX Kd = 3.3 nM YIX C19 H23 N5 O S CCNC(=O)NC....
21 3OCG ic50 = 3 nM OCG C21 H18 N6 O3 Cc1ccc(cc1....
22 1BL7 - SB4 C18 H19 F N6 c1cc(ccc1c....
23 3P7C ic50 = 0.022 uM P7C C25 H33 Cl2 N5 O3 S CC(C)(C)c1....
24 5TBE Kd = 4.4 nM 78L C33 H30 F2 N4 O4 S c1cc(sc1)C....
25 4KIP ic50 = 7 nM 1R9 C21 H18 Cl N3 O2 S Cc1ccc(cc1....
26 2EWA - SB2 C21 H16 F N3 O S C[S@](=O)c....
27 2GHL - LIB C23 H26 Cl N5 O3 C[C@@H](C(....
28 1ZZ2 ic50 = 6 uM B11 C24 H26 F N3 O4 S c1ccc(c(c1....
29 3ZSI - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
30 2YIW - YIW C30 H33 N7 O S CC(C)c1nnc....
31 5WJJ ic50 = 5.4 nM AQY C25 H19 F N6 O2 Cc1cc(ccc1....
32 1A9U - SB2 C21 H16 F N3 O S C[S@](=O)c....
33 1M7Q ic50 = 2.6 nM DQO C24 H20 Cl2 F2 N4 O c1cc(c(c(c....
34 5MTY Kd = 1.3 nM HB9 C29 H23 F2 N3 O4 S c1cc(sc1)C....
35 4EH7 - IRG C17 H16 N4 c1ccc(cc1)....
36 1YQJ ic50 = 7.3 nM 6NP C30 H27 N5 c1ccc(cc1)....
37 4EH3 - NAR C15 H12 O5 c1cc(ccc1[....
38 4AA5 ic50 = 6.7 nM NQB C24 H27 N5 O2 Cc1ccc(cc1....
39 1OVE ic50 = 0.74 nM 358 C26 H22 Cl2 F2 N2 O c1cc(c(c(c....
40 3UVP ic50 = 0.035 uM 048 C24 H21 F N2 O2 c1ccc(cc1)....
41 5N67 - 8ON C28 H30 N6 O CC(=O)N1CC....
42 3NNV ic50 = 27 nM 437 C25 H26 N4 O2 CC(C)(C)c1....
43 3CTQ ic50 = 40 nM 337 C30 H34 N6 O5 S Cc1ccc(cc1....
44 3IW7 - IPK C26 H26 N4 O S c1ccc(cc1)....
45 3ITZ ic50 = 1.4 nM P66 C21 H15 Cl F2 N6 O c1cc(c(c(c....
46 2ZB1 Ki = 0.48 uM GK4 C21 H21 N3 O2 Cc1ccc(cc1....
47 3HV5 ic50 = 150 nM R24 C30 H29 N7 O3 Cc1ccc(cc1....
48 1WBW ic50 = 44 uM LI4 C16 H14 N2 O c1ccc2c(c1....
49 3P79 ic50 = 2.3 uM P79 C24 H29 N5 O4 S CC(C)(C)c1....
50 3HV7 ic50 = 90 nM 1AU C24 H25 N5 O CC(C)(C)c1....
51 3GFE ic50 = 3.2 nM P37 C24 H21 F2 N5 O2 Cc1ccc(cc1....
52 3ZYA - 2A8 C21 H18 N2 O c1ccc2c(c1....
53 2RG5 ic50 = 3.1 nM 279 C19 H22 N6 O3 CCNC(=O)c1....
54 3L8X ic50 = 10 nM N4D C20 H18 N6 O Cc1ccc(cc1....
55 3GCS Kd = 56 nM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
56 3ZS5 - SB2 C21 H16 F N3 O S C[S@](=O)c....
57 3D83 Ki = 4.4 nM GK6 C28 H30 N4 O3 Cc1ccc(cc1....
58 1YW2 ic50 = 141 nM PGJ C22 H18 F N3 O5 CCOC[N@]1C....
59 1W82 ic50 = 196 nM L10 C20 H21 Cl N4 O CC(C)(C)C1....
60 3ZSG - T75 C24 H21 N3 O S CCc1nc(c(s....
61 5TCO Kd = 3.14 nM 79Q C35 H33 F N4 O4 c1ccc(cc1)....
62 4EH8 - IRG C17 H16 N4 c1ccc(cc1)....
63 3GCP Kd = 15 nM SB2 C21 H16 F N3 O S C[S@](=O)c....
64 3HLL Ki = 0.0058 uM I45 C22 H19 Br F2 N2 O3 Cc1ccc(cc1....
65 1ZZL ic50 = 5 nM TZY C18 H15 F N4 O CC(C)c1nnc....
66 2RG6 ic50 = 2.2 nM 287 C25 H26 N6 O3 Cc1ccc(cc1....
67 3MPT ic50 = 0.25 uM 1GK C18 H16 N2 O3 Cc1ccccc1C....
68 1BL6 - SB6 C18 H16 F N3 c1cc(ccc1c....
69 3NNW ic50 = 9 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
70 3GI3 Kd < 1.8 nM B10 C33 H39 N5 O5 S CC(C)(C)c1....
71 3K3J - I46 C14 H9 F2 N3 c1cc(ccc1c....
72 3HEC ic50 = 70 uM STI C29 H31 N7 O Cc1ccc(cc1....
73 1IAN - D13 C21 H16 I N3 O S C[S@@](=O)....
74 3FC1 - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
75 3MVM ic50 = 13 nM 39P C22 H23 N7 O3 CCCNC(=O)c....
76 3NNU ic50 = 48 nM EDB C22 H17 Cl2 N5 O2 S c1cc(cc(c1....
77 1W7H ic50 = 1 mM 3IP C12 H12 N2 O c1ccc(cc1)....
78 3U8W ic50 = 1 nM 09J C24 H21 Cl F N5 O2 CCN1C(=O)C....
79 1WBS ic50 = 0.63 uM LI2 C26 H25 F N4 O2 c1cc2c(cc1....
80 4E6C Kd ~ 15 uM 0O8 C25 H53 N O4 P CCCCCCCCCC....
81 5N68 - 8OK C26 H27 N5 O c1ccc(cc1)....
82 1WBV ic50 = 162 uM LI3 C19 H18 F N3 O2 c1cc2c(cc[....
83 4EH2 - IRG C17 H16 N4 c1ccc(cc1)....
84 3HA8 - 5JZ C36 H38 N8 O5 CCOc1nc(nc....
85 3HEG ic50 = 0.057 uM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
86 2ZAZ Ki = 0.4 uM GK1 C20 H15 N3 O2 S Cc1ccc(cc1....
87 3HP5 - I46 C14 H9 F2 N3 c1cc(ccc1c....
88 5ML5 ic50 = 10 nM 1VI C26 H25 F N4 O3 S COc1ccc(c(....
89 4DLI Kd = 2.4 uM IRG C17 H16 N4 c1ccc(cc1)....
90 3P78 ic50 = 0.11 uM P78 C24 H27 N3 O4 S2 CC(C)(C)c1....
91 4EH9 - IRG C17 H16 N4 c1ccc(cc1)....
92 1YWR ic50 = 32 nM LI9 C27 H29 F N6 O C[C@@H](c1....
93 3IW5 Kd = 0.839 uM DF3 C28 H24 F3 N3 O4 S c1ccc2c(c1....
94 3HV3 ic50 = 900 nM R49 C30 H31 N7 O Cc1cccc(c1....
95 4A9Y - RNY C32 H37 N7 O4 Cc1ccc(cc1....
96 3GCU - R48 C29 H30 N8 O Cc1ccc(cc1....
97 1OUY ic50 = 4.3 nM 094 C24 H18 Cl2 F2 N4 O S c1cc(c(c(c....
98 3D7Z Ki = 12 nM GK5 C22 H24 N2 O2 Cc1ccc(cc1....
99 2YIS - YIS C35 H34 Cl N7 O3 S2 CC(C)(C)c1....
100 1OUK ic50 = 0.13 nM 084 C28 H29 F3 N6 C[C@@H](c1....
101 3BV2 Ki = 0.44 nM P38 C33 H32 N8 O3 Cc1ccc(cc1....
102 4R3C - GG5 C14 H10 F N3 c1cc(ccc1c....
103 4L8M ic50 = 0.001 uM F46 C33 H30 F N3 O5 c1ccc(cc1)....
104 4E6A - 0O9 C32 H65 O10 P CCCCCCCCCC....
105 1WBN ic50 = 0.35 uM L09 C20 H22 Cl N5 O2 CC(C)(C)c1....
106 2QD9 ic50 = 13 nM LGF C27 H24 F2 N6 O5 COc1c(cc2c....
107 3HUC Kd = 1030 nM G97 C20 H16 N6 O C=CC(=O)Nc....
108 3HL7 Ki = 0.023 uM I47 C20 H20 Cl N5 O2 c1cc(ccc1c....
109 4EHV - IRG C17 H16 N4 c1ccc(cc1)....
110 2GTN ic50 = 4 nM LIE C20 H16 F3 N5 O CC(C)n1c2c....
111 3HRB ic50 = 21 nM I39 C19 H14 F2 N2 O2 Cc1ccccc1c....
112 3BX5 ic50 = 1.5 nM 304 C17 H22 N4 O2 S CC[C@@H](C....
113 3HVC ic50 = 600 nM GG5 C14 H10 F N3 c1cc(ccc1c....
114 2GFS ic50 = 0.7 uM PQB C19 H18 F N3 O4 c1cc(cc(c1....
115 5N63 - 8OW C21 H17 F N4 c1ccc(cc1)....
116 2NPQ Kd = 3.08 uM BOG C14 H28 O6 CCCCCCCCO[....
117 3IW6 Kd = 3.29 uM PP0 C23 H31 N3 O3 CCn1c(c(c(....
118 3S4Q ic50 = 4 nM NK0 C25 H23 N5 O2 Cc1ccc(cc1....
119 2BAJ Kd = 4 nM 1PP C20 H20 Cl2 N4 O CC(C)(C)c1....
120 3ROC - 29B C14 H10 F N3 c1cc(ccc1c....
121 3NWW ic50 = 7 nM 3NW C24 H34 N8 O S CCNC(=O)NC....
122 1W83 ic50 = 0.065 uM L11 C23 H25 Cl F N3 O3 c1cc(cnc1)....
123 3ZSH - 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
124 3IPH Ki = 0.0000251 mM G11 C21 H23 N3 O2 Cc1ccc(cc1....
125 5MZ3 ic50 = 0.00021 uM 8EN C24 H19 F3 N4 O2 Cc1ccc(cc1....
126 3P7B ic50 = 0.018 uM P7B C25 H28 N4 O3 S CC(C)(C)c1....
127 3GCQ Kd = 342 nM 1BU C29 H30 N8 O Cc1cccc(c1....
128 4F9Y Ki = 184 nM LM3 C21 H18 N4 CN(C)c1cc(....
129 2BAL Kd = 490 nM PQA C21 H21 F N4 O2 c1cc(cc(c1....
130 3HUB Kd = 8.2 nM 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
131 4F9W Ki = 114 nM LM4 C21 H18 N4 CN(C)c1cc(....
132 3P5K ic50 = 0.076 uM P5K C24 H27 N3 O4 S2 CC(C)(C)c1....
133 2I0H ic50 = 9 nM 222 C27 H19 Cl2 F N4 O3 c1ccc2c(c1....
134 1ZYJ ic50 = 1.5 uM BI5 C19 H16 N2 O2 c1ccc(cc1)....
135 3K3I - JZJ C18 H16 Br N3 c1ccc2c(c1....
136 1WBT ic50 = 0.34 uM WBT C26 H25 F N4 O2 c1cc(cc2c1....
137 1BMK - SB5 C17 H16 F N5 c1cc(ccc1c....
138 3E92 Ki = 10 nM G6A C21 H21 N3 O2 Cc1ccc(cc1....
139 3P7A ic50 = 0.52 uM P7A C23 H27 N3 O3 S2 CC(C)(C)c1....
140 6ANL ic50 = 240 nM T75 C24 H21 N3 O S CCc1nc(c(s....
141 3NNX ic50 = 11 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
142 4EH4 - IRG C17 H16 N4 c1ccc(cc1)....
143 1KV1 Kd = 1.16 uM BMU C15 H19 Cl N4 O CC(C)(C)c1....
144 3KF7 ic50 = 40 nM L9G C22 H18 F2 N4 O Cc1ccc(cc1....
145 4KIN ic50 = 4.8 nM 1M8 C22 H19 Cl N2 O2 S Cc1ccc(cc1....
146 4AA4 ic50 = 9 nM QC0 C25 H25 N5 O3 Cc1ccc(cc1....
147 5XYY ic50 = 9.221 uM P0F C15 H12 Cl F N4 O c1cc(cc(c1....
148 3E93 Ki = 1.4 nM 19B C30 H32 N4 O3 Cc1ccc(cc1....
149 4AAC ic50 = 16 nM AAV C24 H24 N6 O3 Cc1ccc(cc1....
150 4AA0 ic50 = 35 nM AA0 C30 H33 N7 O3 Cc1ccc(cc1....
151 1OZ1 ic50 = 6.5 nM FPH C18 H12 F N3 O c1cc2c(c(c....
152 5N64 - 8OH C19 H16 N4 S c1ccc(cc1)....
153 3IW8 Kd = 13.4 uM HIZ C19 H18 Cl F N4 O2 S c1ccc(cc1)....
154 3GC8 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
155 3GC9 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
156 4EYM - 0RX C21 H20 N4 O3 c1cc(ccc1N....
157 5EKO ic50 = 15785 nM N17 C22 H18 N4 O2 Cc1cn(cn1)....
158 4EYJ - N61 C20 H23 N5 O2 CC(C)(C)c1....
159 1CM8 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
50% Homology Family (281)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 60 families.
1 4FBX - 0TJ GLY ASP ASP ASP ASP ASP n/a n/a
2 5OUU - AWN C22 H20 Cl N3 c1ccc(cc1)....
3 4RLL - E91 C21 H14 N2 O2 c1ccc2c(c1....
4 5CU4 Kd = 0.32 uM 54S C26 H26 Cl N3 O4 c1ccc(cc1)....
5 4O6E ic50 = 1 nM 2SH C21 H25 Cl F N5 O3 c1cc(c(cc1....
6 5NHJ ic50 < 0.0003 uM 8XE C18 H21 N7 O2 Cn1c(ccn1)....
7 4QYY Kd = 0.05 uM 3G7 C25 H29 Cl N4 O4 CC(=O)c1cc....
8 4I5H Ki < 2 nM G17 C26 H21 F3 N4 O Cc1ccc(cc1....
9 6G93 ic50 = 11 nM EU2 C17 H17 Cl N4 O2 c1cc2c(cc1....
10 4QTE Kd = 0.084 uM 390 C24 H20 Cl2 F N5 O2 Cc1cnc(nc1....
11 4XNE - TT4 C8 H9 N5 c1ccc(cc1)....
12 3QYW - 6PB C11 H8 Br N5 c1cc(cc(c1....
13 5BUE ic50 = 0.003 uM 4V8 C23 H21 N5 O c1ccc(cc1)....
14 6GE0 ic50 = 2.1 nM EVQ C28 H30 Cl N5 O4 C[C@H](c1c....
15 6G9N ic50 = 3 nM ESN C29 H32 Cl N5 O4 Cc1cccc(c1....
16 2Z7L - S91 C20 H19 N5 O3 Cc1cccc(c1....
17 4ZXT - CAQ C6 H6 O2 c1ccc(c(c1....
18 1WZY ic50 = 0.56 uM F29 C21 H17 N7 C=CCn1c2c(....
19 6DMG - EK6 C27 H26 Cl2 F N5 O4 CCOC(=O)CN....
20 5NHH ic50 < 0.00113 uM 8XH C19 H25 N5 O3 COCCN1CCc2....
21 6G9H ic50 = 4 nM ERW C24 H30 Cl N5 O3 CC(C)(C)N(....
22 4N4S - 2H1 C25 H24 N6 O Cc1cc(cc2c....
23 4QP8 ic50 = 0.28 uM 362 C14 H10 N6 c1cc(cnc1)....
24 4QP4 - 36O C11 H15 N5 c1[nH]c2c(....
25 6G9D ic50 = 4.3 nM ER8 C23 H28 Cl N5 O3 CC(C)(C)NC....
26 6GJB ic50 = 0.008 uM F0H C35 H34 Cl F N6 O4 c1cc(c(cc1....
27 6G91 ic50 = 3200 nM EQW C9 H12 Cl N3 O c1c(cnc(n1....
28 6G8X - EQT C7 H6 Cl N3 c1cc2c(c(c....
29 6DCG ic50 = 7 nM G67 C37 H41 N9 O3 S CC(C)Oc1cc....
30 4QP9 ic50 = 0.071 uM 35X C17 H16 N6 CCCn1cc(cn....
31 5BVE ic50 = 0.01 nM 4VG C25 H28 Cl N5 O3 c1cc(cc(c1....
32 5KE0 - 6S9 C20 H18 N6 O Cc1cc(ccn1....
33 6CPW ic50 = 5.6 nM F8V C35 H35 F N8 O2 S CS[C@]1(CC....
34 4XOY - DX4 C5 H5 N5 S c1[nH]c2c(....
35 6G9K - ESK C27 H28 Cl N5 O4 c1ccc(cc1)....
36 3QYZ - Z8B C10 H11 Br N8 O3 c1nc(c2c(n....
37 5BVF ic50 = 0.19 nM 4VJ C25 H28 Cl N5 O3 c1cc(cc(c1....
38 6G9M ic50 = 7.9 nM ESW C28 H30 Cl N5 O3 CC(C)(c1cc....
39 4XOZ - 620 C15 H16 N6 O c1ccc(cc1)....
40 5HD7 - 38Z C33 H33 N9 O2 c1cnc(nc1)....
41 4XRJ - 620 C15 H16 N6 O c1ccc(cc1)....
42 2OJJ Ki = 0.002 uM 82A C22 H17 Cl2 F N4 O2 c1cc(cc(c1....
43 4QTA Kd = 0.013 uM 38Z C33 H33 N9 O2 c1cnc(nc1)....
44 5NHO ic50 < 0.0003 uM 8XN C20 H25 N7 O2 Cc1cnc(nc1....
45 2OJG Ki = 2.3 uM 19A C16 H16 N4 O CN(C)C(=O)....
46 4XP0 - 42A C8 H5 N3 c1cc2c(c[n....
47 4QP2 Kd = 940 uM 36R C7 H5 Cl N2 O c1cc2c(cc1....
48 5NHF ic50 = 0.0012 uM 8X5 C23 H25 N5 O2 c1ccc(cc1)....
49 5BUJ ic50 = 0.005 uM 4VB C16 H15 N5 O c1cnccc1c2....
50 6G9J ic50 = 4.1 nM ERK C27 H28 Cl N5 O3 C[C@H](c1c....
51 5BUI ic50 = 0.089 uM 4V9 C17 H15 F N4 c1ccnc(c1)....
52 4QP7 ic50 = 5.9 uM 363 C9 H7 N5 c1c[nH]c2c....
53 3ERK ic50 = 18 uM SB4 C18 H19 F N6 c1cc(ccc1c....
54 6GDQ - EVK C21 H22 Cl2 N4 O2 CC(C)Nc1cc....
55 5V60 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
56 1TVO Ki = 0.14 uM FRZ C18 H13 N7 c1ccc(cc1)....
57 6G9A ic50 = 21 nM ESQ C23 H28 Cl N5 O3 c1cc2c(cc1....
58 5BVD ic50 = 0.16 nM 4VF C24 H26 Cl N5 O3 c1cc(cc(c1....
59 4ZZN ic50 = 0.26 uM CQ8 C18 H21 Cl N4 O2 CNC(=O)c1c....
60 3SA0 - NRA C13 H8 O6 c1c(cc2c(c....
61 4ERK ic50 = 27 uM OLO C15 H18 N6 O Cn1cnc2c1n....
62 6GJD ic50 = 0.022 uM F0E C46 H55 N11 O5 c1cnc(nc1)....
63 5U6I - 81Y C19 H22 N4 O2 CC(C)Oc1cc....
64 5NHV ic50 = 0.0028 uM 8QB C16 H19 N5 O2 c1cnc(nc1c....
65 3I5Z Ki = 2 nM Z48 C24 H23 N5 O2 Cc1cnc(nc1....
66 4N0S - DHC C9 H8 O4 c1cc(c(cc1....
67 5NHP ic50 = 0.023 uM 8XK C19 H23 N7 O2 Cn1c(ccn1)....
68 3I60 Ki < 2 nM E86 C24 H22 Cl N5 O2 Cc1cnc(nc1....
69 4XP2 - TT4 C8 H9 N5 c1ccc(cc1)....
70 1PME Ki = 0.76 nM SB2 C21 H16 F N3 O S C[S@](=O)c....
71 5NHL ic50 < 0.0003 uM 8XB C20 H25 N7 O2 Cc1cnc(nc1....
72 5HD4 - 38Z C33 H33 N9 O2 c1cnc(nc1)....
73 6G97 ic50 = 4.2 nM EQZ C20 H23 Cl N4 O3 COCCN1Cc2c....
74 6G92 ic50 = 76000 nM ERZ C10 H13 N5 Cc1cnc(nc1....
75 5K4I ic50 = 3.1 nM 6QB C21 H18 Cl F N6 O2 Cn1c(ccn1)....
76 4FA2 - SB0 C20 H21 F N4 O2 COc1nccc(n....
77 2GHM - LIC C24 H28 Cl N5 O3 C[C@@H](C(....
78 1W84 ic50 = 35 uM L12 C15 H14 N2 c1ccc2c(c1....
79 4EH5 - IRG C17 H16 N4 c1ccc(cc1)....
80 2BAK Kd = 37 nM AQZ C32 H37 N7 O4 Cc1ccc(cc1....
81 3HV6 ic50 = 5500 nM R39 C27 H35 N5 O3 Cc1ccc(cc1....
82 3HP2 - P36 C19 H16 Br N O2 c1ccc(cc1)....
83 1WBO ic50 = 1 mM 2CH C6 H5 Cl O c1ccc(c(c1....
84 4KIQ ic50 = 23 nM 1RA C23 H23 N3 O4 CCOC(=O)n1....
85 3GC7 ic50 = 0.4 nM B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
86 4EH6 - IRG C17 H16 N4 c1ccc(cc1)....
87 5MTX Kd = 17.7 nM FJI C34 H31 F N4 O5 c1ccc(cc1)....
88 2ZB0 Ki = 0.24 uM GK3 C24 H18 N4 O2 Cc1ccc(cc1....
89 2GTM ic50 = 542 nM LID C19 H15 Cl F2 N6 CCn1c2c(cn....
90 5N66 - B96 C31 H37 N5 O3 Cc1ccc(cc1....
91 2YIX Kd = 3.3 nM YIX C19 H23 N5 O S CCNC(=O)NC....
92 3OCG ic50 = 3 nM OCG C21 H18 N6 O3 Cc1ccc(cc1....
93 1BL7 - SB4 C18 H19 F N6 c1cc(ccc1c....
94 3P7C ic50 = 0.022 uM P7C C25 H33 Cl2 N5 O3 S CC(C)(C)c1....
95 5TBE Kd = 4.4 nM 78L C33 H30 F2 N4 O4 S c1cc(sc1)C....
96 4KIP ic50 = 7 nM 1R9 C21 H18 Cl N3 O2 S Cc1ccc(cc1....
97 2EWA - SB2 C21 H16 F N3 O S C[S@](=O)c....
98 2GHL - LIB C23 H26 Cl N5 O3 C[C@@H](C(....
99 1ZZ2 ic50 = 6 uM B11 C24 H26 F N3 O4 S c1ccc(c(c1....
100 3ZSI - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
101 2YIW - YIW C30 H33 N7 O S CC(C)c1nnc....
102 5WJJ ic50 = 5.4 nM AQY C25 H19 F N6 O2 Cc1cc(ccc1....
103 1A9U - SB2 C21 H16 F N3 O S C[S@](=O)c....
104 1M7Q ic50 = 2.6 nM DQO C24 H20 Cl2 F2 N4 O c1cc(c(c(c....
105 5MTY Kd = 1.3 nM HB9 C29 H23 F2 N3 O4 S c1cc(sc1)C....
106 4EH7 - IRG C17 H16 N4 c1ccc(cc1)....
107 1YQJ ic50 = 7.3 nM 6NP C30 H27 N5 c1ccc(cc1)....
108 4EH3 - NAR C15 H12 O5 c1cc(ccc1[....
109 4AA5 ic50 = 6.7 nM NQB C24 H27 N5 O2 Cc1ccc(cc1....
110 1OVE ic50 = 0.74 nM 358 C26 H22 Cl2 F2 N2 O c1cc(c(c(c....
111 3UVP ic50 = 0.035 uM 048 C24 H21 F N2 O2 c1ccc(cc1)....
112 5N67 - 8ON C28 H30 N6 O CC(=O)N1CC....
113 3NNV ic50 = 27 nM 437 C25 H26 N4 O2 CC(C)(C)c1....
114 3CTQ ic50 = 40 nM 337 C30 H34 N6 O5 S Cc1ccc(cc1....
115 3IW7 - IPK C26 H26 N4 O S c1ccc(cc1)....
116 3ITZ ic50 = 1.4 nM P66 C21 H15 Cl F2 N6 O c1cc(c(c(c....
117 2ZB1 Ki = 0.48 uM GK4 C21 H21 N3 O2 Cc1ccc(cc1....
118 3HV5 ic50 = 150 nM R24 C30 H29 N7 O3 Cc1ccc(cc1....
119 1WBW ic50 = 44 uM LI4 C16 H14 N2 O c1ccc2c(c1....
120 3P79 ic50 = 2.3 uM P79 C24 H29 N5 O4 S CC(C)(C)c1....
121 3HV7 ic50 = 90 nM 1AU C24 H25 N5 O CC(C)(C)c1....
122 3GFE ic50 = 3.2 nM P37 C24 H21 F2 N5 O2 Cc1ccc(cc1....
123 3ZYA - 2A8 C21 H18 N2 O c1ccc2c(c1....
124 2RG5 ic50 = 3.1 nM 279 C19 H22 N6 O3 CCNC(=O)c1....
125 3L8X ic50 = 10 nM N4D C20 H18 N6 O Cc1ccc(cc1....
126 3GCS Kd = 56 nM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
127 3ZS5 - SB2 C21 H16 F N3 O S C[S@](=O)c....
128 3D83 Ki = 4.4 nM GK6 C28 H30 N4 O3 Cc1ccc(cc1....
129 1YW2 ic50 = 141 nM PGJ C22 H18 F N3 O5 CCOC[N@]1C....
130 1W82 ic50 = 196 nM L10 C20 H21 Cl N4 O CC(C)(C)C1....
131 3ZSG - T75 C24 H21 N3 O S CCc1nc(c(s....
132 5TCO Kd = 3.14 nM 79Q C35 H33 F N4 O4 c1ccc(cc1)....
133 4EH8 - IRG C17 H16 N4 c1ccc(cc1)....
134 3GCP Kd = 15 nM SB2 C21 H16 F N3 O S C[S@](=O)c....
135 3HLL Ki = 0.0058 uM I45 C22 H19 Br F2 N2 O3 Cc1ccc(cc1....
136 1ZZL ic50 = 5 nM TZY C18 H15 F N4 O CC(C)c1nnc....
137 2RG6 ic50 = 2.2 nM 287 C25 H26 N6 O3 Cc1ccc(cc1....
138 3MPT ic50 = 0.25 uM 1GK C18 H16 N2 O3 Cc1ccccc1C....
139 1BL6 - SB6 C18 H16 F N3 c1cc(ccc1c....
140 3NNW ic50 = 9 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
141 3GI3 Kd < 1.8 nM B10 C33 H39 N5 O5 S CC(C)(C)c1....
142 3K3J - I46 C14 H9 F2 N3 c1cc(ccc1c....
143 3HEC ic50 = 70 uM STI C29 H31 N7 O Cc1ccc(cc1....
144 1IAN - D13 C21 H16 I N3 O S C[S@@](=O)....
145 3FC1 - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
146 3MVM ic50 = 13 nM 39P C22 H23 N7 O3 CCCNC(=O)c....
147 3NNU ic50 = 48 nM EDB C22 H17 Cl2 N5 O2 S c1cc(cc(c1....
148 1W7H ic50 = 1 mM 3IP C12 H12 N2 O c1ccc(cc1)....
149 3U8W ic50 = 1 nM 09J C24 H21 Cl F N5 O2 CCN1C(=O)C....
150 1WBS ic50 = 0.63 uM LI2 C26 H25 F N4 O2 c1cc2c(cc1....
151 4E6C Kd ~ 15 uM 0O8 C25 H53 N O4 P CCCCCCCCCC....
152 5N68 - 8OK C26 H27 N5 O c1ccc(cc1)....
153 1WBV ic50 = 162 uM LI3 C19 H18 F N3 O2 c1cc2c(cc[....
154 4EH2 - IRG C17 H16 N4 c1ccc(cc1)....
155 3HA8 - 5JZ C36 H38 N8 O5 CCOc1nc(nc....
156 3HEG ic50 = 0.057 uM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
157 2ZAZ Ki = 0.4 uM GK1 C20 H15 N3 O2 S Cc1ccc(cc1....
158 3HP5 - I46 C14 H9 F2 N3 c1cc(ccc1c....
159 5ML5 ic50 = 10 nM 1VI C26 H25 F N4 O3 S COc1ccc(c(....
160 4DLI Kd = 2.4 uM IRG C17 H16 N4 c1ccc(cc1)....
161 3P78 ic50 = 0.11 uM P78 C24 H27 N3 O4 S2 CC(C)(C)c1....
162 4EH9 - IRG C17 H16 N4 c1ccc(cc1)....
163 1YWR ic50 = 32 nM LI9 C27 H29 F N6 O C[C@@H](c1....
164 3IW5 Kd = 0.839 uM DF3 C28 H24 F3 N3 O4 S c1ccc2c(c1....
165 3HV3 ic50 = 900 nM R49 C30 H31 N7 O Cc1cccc(c1....
166 4A9Y - RNY C32 H37 N7 O4 Cc1ccc(cc1....
167 3GCU - R48 C29 H30 N8 O Cc1ccc(cc1....
168 1OUY ic50 = 4.3 nM 094 C24 H18 Cl2 F2 N4 O S c1cc(c(c(c....
169 3D7Z Ki = 12 nM GK5 C22 H24 N2 O2 Cc1ccc(cc1....
170 2YIS - YIS C35 H34 Cl N7 O3 S2 CC(C)(C)c1....
171 1OUK ic50 = 0.13 nM 084 C28 H29 F3 N6 C[C@@H](c1....
172 3BV2 Ki = 0.44 nM P38 C33 H32 N8 O3 Cc1ccc(cc1....
173 4R3C - GG5 C14 H10 F N3 c1cc(ccc1c....
174 4L8M ic50 = 0.001 uM F46 C33 H30 F N3 O5 c1ccc(cc1)....
175 4E6A - 0O9 C32 H65 O10 P CCCCCCCCCC....
176 1WBN ic50 = 0.35 uM L09 C20 H22 Cl N5 O2 CC(C)(C)c1....
177 2QD9 ic50 = 13 nM LGF C27 H24 F2 N6 O5 COc1c(cc2c....
178 3HUC Kd = 1030 nM G97 C20 H16 N6 O C=CC(=O)Nc....
179 3HL7 Ki = 0.023 uM I47 C20 H20 Cl N5 O2 c1cc(ccc1c....
180 4EHV - IRG C17 H16 N4 c1ccc(cc1)....
181 2GTN ic50 = 4 nM LIE C20 H16 F3 N5 O CC(C)n1c2c....
182 3HRB ic50 = 21 nM I39 C19 H14 F2 N2 O2 Cc1ccccc1c....
183 3BX5 ic50 = 1.5 nM 304 C17 H22 N4 O2 S CC[C@@H](C....
184 3HVC ic50 = 600 nM GG5 C14 H10 F N3 c1cc(ccc1c....
185 2GFS ic50 = 0.7 uM PQB C19 H18 F N3 O4 c1cc(cc(c1....
186 5N63 - 8OW C21 H17 F N4 c1ccc(cc1)....
187 2NPQ Kd = 3.08 uM BOG C14 H28 O6 CCCCCCCCO[....
188 3IW6 Kd = 3.29 uM PP0 C23 H31 N3 O3 CCn1c(c(c(....
189 3S4Q ic50 = 4 nM NK0 C25 H23 N5 O2 Cc1ccc(cc1....
190 2BAJ Kd = 4 nM 1PP C20 H20 Cl2 N4 O CC(C)(C)c1....
191 3ROC - 29B C14 H10 F N3 c1cc(ccc1c....
192 3NWW ic50 = 7 nM 3NW C24 H34 N8 O S CCNC(=O)NC....
193 1W83 ic50 = 0.065 uM L11 C23 H25 Cl F N3 O3 c1cc(cnc1)....
194 3ZSH - 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
195 3IPH Ki = 0.0000251 mM G11 C21 H23 N3 O2 Cc1ccc(cc1....
196 5MZ3 ic50 = 0.00021 uM 8EN C24 H19 F3 N4 O2 Cc1ccc(cc1....
197 3P7B ic50 = 0.018 uM P7B C25 H28 N4 O3 S CC(C)(C)c1....
198 3GCQ Kd = 342 nM 1BU C29 H30 N8 O Cc1cccc(c1....
199 4F9Y Ki = 184 nM LM3 C21 H18 N4 CN(C)c1cc(....
200 2BAL Kd = 490 nM PQA C21 H21 F N4 O2 c1cc(cc(c1....
201 3HUB Kd = 8.2 nM 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
202 4F9W Ki = 114 nM LM4 C21 H18 N4 CN(C)c1cc(....
203 3P5K ic50 = 0.076 uM P5K C24 H27 N3 O4 S2 CC(C)(C)c1....
204 2I0H ic50 = 9 nM 222 C27 H19 Cl2 F N4 O3 c1ccc2c(c1....
205 1ZYJ ic50 = 1.5 uM BI5 C19 H16 N2 O2 c1ccc(cc1)....
206 3K3I - JZJ C18 H16 Br N3 c1ccc2c(c1....
207 1WBT ic50 = 0.34 uM WBT C26 H25 F N4 O2 c1cc(cc2c1....
208 1BMK - SB5 C17 H16 F N5 c1cc(ccc1c....
209 3E92 Ki = 10 nM G6A C21 H21 N3 O2 Cc1ccc(cc1....
210 3P7A ic50 = 0.52 uM P7A C23 H27 N3 O3 S2 CC(C)(C)c1....
211 6ANL ic50 = 240 nM T75 C24 H21 N3 O S CCc1nc(c(s....
212 3NNX ic50 = 11 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
213 4EH4 - IRG C17 H16 N4 c1ccc(cc1)....
214 1KV1 Kd = 1.16 uM BMU C15 H19 Cl N4 O CC(C)(C)c1....
215 3KF7 ic50 = 40 nM L9G C22 H18 F2 N4 O Cc1ccc(cc1....
216 4KIN ic50 = 4.8 nM 1M8 C22 H19 Cl N2 O2 S Cc1ccc(cc1....
217 4AA4 ic50 = 9 nM QC0 C25 H25 N5 O3 Cc1ccc(cc1....
218 5XYY ic50 = 9.221 uM P0F C15 H12 Cl F N4 O c1cc(cc(c1....
219 3E93 Ki = 1.4 nM 19B C30 H32 N4 O3 Cc1ccc(cc1....
220 4AAC ic50 = 16 nM AAV C24 H24 N6 O3 Cc1ccc(cc1....
221 4AA0 ic50 = 35 nM AA0 C30 H33 N7 O3 Cc1ccc(cc1....
222 1OZ1 ic50 = 6.5 nM FPH C18 H12 F N3 O c1cc2c(c(c....
223 5N64 - 8OH C19 H16 N4 S c1ccc(cc1)....
224 3IW8 Kd = 13.4 uM HIZ C19 H18 Cl F N4 O2 S c1ccc(cc1)....
225 3TTI ic50 = 0.006 uM KBI C21 H23 F3 N6 O2 c1c(cc(c(c....
226 3TTJ ic50 = 0.21 uM JBI C23 H23 F N6 O COc1ccc(cc....
227 1JNK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
228 3KVX ic50 = 0.148 uM FMY C26 H27 F N8 O2 c1cc(ccc1/....
229 4H39 Kd = 0.8 uM PRO LYS ARG PRO THR THR LEU ASN LEU PHE n/a n/a
230 4AWI ic50 = 1 uM AQ2 C21 H25 N3 O4 S2 CC(C)c1cc2....
231 2O0U ic50 = 3.2 uM C0M C27 H28 N4 O2 S c1ccc2c(c1....
232 2P33 ic50 = 57 nM J07 C20 H23 Cl N6 O CCNC(=O)N1....
233 2ZDU - 446 C28 H23 Br N2 O6 COC(=O)C1=....
234 2B1P ic50 = 3 nM AIZ C26 H26 Cl N5 O3 CN(C)CCCC(....
235 2OK1 Ki = 0.55 uM 33A C21 H17 Cl N4 O c1ccc(cc1)....
236 3OXI ic50 = 2.2 uM SYY C12 H11 N O3 S2 COC(=O)c1c....
237 3OY1 ic50 = 0.016 uM 589 C28 H31 N5 O2 c1ccc2cc(c....
238 6EMH ic50 = 833 nM BGE C19 H21 N5 O Cc1c([nH]c....
239 2ZDT - 46C C26 H20 Cl N O4 CCC(=O)C1=....
240 3ELJ - GS7 C22 H21 F N6 O4 S COc1cc(ccc....
241 3FI2 ic50 = 0.025 uM JK1 C26 H25 N5 O5 COc1cc(cc(....
242 4L7F ic50 = 160 nM 1V5 C26 H26 F N5 O2 c1cc(ccc1C....
243 6EQ9 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
244 2WAJ ic50 = 0.398 uM SNB C16 H13 Br Cl N O COc1cc2c(c....
245 4QTD ic50 = 1080 nM 38Z C33 H33 N9 O2 c1cnc(nc1)....
246 6EKD ic50 = 184 nM B9K C20 H23 N5 O S Cc1c([nH]c....
247 3G9L Ki = 0.74 uM J67 C25 H19 F N2 O4 c1ccc(cc1)....
248 4Y46 ic50 = 11 nM 4F2 C22 H32 N6 O2 CC(C)NC(=O....
249 1PMN ic50 = 7.1 nM 984 C25 H30 Cl2 N6 CCCn1c(c(n....
250 3FI3 ic50 = 12 nM JK2 C29 H25 F N4 O4 COc1cc(cc(....
251 2O2U ic50 = 4 uM 738 C16 H13 F N2 O S c1ccc(c(c1....
252 4W4V ic50 = 866 nM 3H8 C23 H19 Cl N6 O2 Cc1cc(ccn1....
253 3DA6 - BZ9 C28 H23 N7 O Cc1cc(c2cc....
254 2R9S ic50 = 0.15 uM 255 C24 H24 N4 O2 S CC(C)(C)NS....
255 4Y5H ic50 = 15 nM 519 C20 H30 N6 O2 CC(C)NC(=O....
256 4X21 Kd = 36 nM 3WH C20 H23 I N6 O CCNC(=O)N1....
257 3RTP ic50 = 7 nM 34I C18 H14 N6 O2 S c1ccc2c(c1....
258 3PZE - CFK C12 H11 N3 O2 S c1ccc(cc1)....
259 4Z9L ic50 = 1.6 nM 880 C27 H34 Cl2 N6 CCCn1c(c(n....
260 4WHZ ic50 < 1 nM 3NL C24 H23 Cl N8 O2 c1ccc(c(c1....
261 4W4Y ic50 = 3034 nM 3HQ C24 H22 N6 O2 Cc1ccc(cc1....
262 4W4W ic50 = 6630 nM 3HJ C23 H20 N6 O2 Cc1cc(ccn1....
263 3G90 Ki = 0.44 uM J72 C17 H12 F2 N2 O4 c1cc2c(cc1....
264 1PMV ic50 = 150 nM 537 C14 H8 N2 O c1ccc2c(c1....
265 3GC8 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
266 3GC9 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
267 2PVH Ki = 0.26 uM P19 C17 H14 N6 c1ccc(cc1)....
268 5BYZ ic50 = 0.042 uM 4WE C25 H32 F N7 O Cc1ncc(n1C....
269 4ZSJ ic50 = 2.3 uM 4R0 C13 H17 Cl N6 O Cc1cc(ccc1....
270 4ZSG - 4QX C12 H15 Cl N6 O CC(C)NC(=O....
271 2F9G - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
272 2B9F - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
273 5AWM - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
274 4EYM - 0RX C21 H20 N4 O3 c1cc(ccc1N....
275 5EKO ic50 = 15785 nM N17 C22 H18 N4 O2 Cc1cn(cn1)....
276 4EYJ - N61 C20 H23 N5 O2 CC(C)(C)c1....
277 1CM8 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
278 4QTB Kd = 0.084 uM 38Z C33 H33 N9 O2 c1cnc(nc1)....
279 2ZOQ ic50 = 0.9 uM 5ID C11 H13 I N4 O4 c1c(c2c(nc....
280 3NPC - B96 C31 H37 N5 O3 Cc1ccc(cc1....
281 3E7O ic50 = 120 nM 35F C20 H14 N6 O2 c1cc(cc(c1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 0RX; Similar ligands found: 4
No: Ligand ECFP6 Tc MDL keys Tc
1 0RX 1 1
2 N17 0.477778 0.655172
3 GK6 0.47 0.758065
4 AA0 0.410714 0.731343
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5EKO; Ligand: N17; Similar sites found with APoc: 368
This union binding pocket(no: 1) in the query (biounit: 5eko.bio1) has 24 residues
No: Leader PDB Ligand Sequence Similarity
1 2QX0 PH2 1.25786
2 2Z48 A2G 1.34771
3 6EOM ALA LYS 1.34771
4 4LH7 1X8 1.54799
5 5HP8 PYR 1.6129
6 5W75 SUC 1.61725
7 5VZ0 ADP 1.61725
8 1I7L ATP 1.61812
9 4ZJS 4P0 1.73913
10 2PUL ACP 1.88679
11 1W2D ADP 1.88679
12 1J1R ADE 1.91571
13 4ZS4 ATP 1.9544
14 2V5E SCR 2
15 3BP1 GUN 2.06897
16 1IA9 ANP 2.14286
17 1M0W ANP 2.15633
18 3K5I ADP 2.15633
19 3PDT ADP 2.18182
20 1AUX AGS 2.2508
21 2II3 CAO 2.29008
22 3COW 52H 2.32558
23 4OUC 5ID 2.52101
24 6G34 5ID 2.52101
25 2GQR ADP 2.53165
26 5GZ9 ANP 2.62295
27 5UC9 MYR 2.65487
28 5I35 ANP 2.69542
29 3ORQ ADP 2.69542
30 1TZD ADP 2.90909
31 5C1P ADP 2.94118
32 2PYW ADP 2.96496
33 5LX9 OLB 3.16901
34 5FPN KYD 3.2345
35 5MW8 ATP 3.2345
36 5IM3 DTP 3.2345
37 2AIQ BEN 3.4632
38 3RS8 ALA TRP LEU PHE GLU ALA 3.50404
39 3CBC DBS 3.53535
40 5XNA SHV 3.62319
41 3VOT ADP 3.77358
42 5OLK DTP 3.77358
43 3VPD ANP 3.91459
44 5ZCT ANP 3.92157
45 3KP6 SAL 3.97351
46 3X01 AMP 4.04313
47 4MRP GSH 4.04313
48 3I0O ADP 4.12979
49 3I0O SMI 4.12979
50 5YK1 ANP 4.31267
51 2YRX AMP 4.31267
52 5VLQ ANP 4.41426
53 6FBA D48 4.58453
54 4MGA 27L 4.70588
55 4XYM A12 4.78261
56 5EQY 5RA 4.85175
57 5OES ADP 4.85175
58 4OCJ NDG 4.85175
59 1CBK ROI 5
60 3NB0 G6P 5.12129
61 4OCV ANP 5.12129
62 5USZ SKE 5.19031
63 3CM2 X23 5.38462
64 3B99 U51 5.39084
65 5OCA 9QZ 5.55556
66 4GYI ADP 5.66038
67 3PN1 IVH 5.97484
68 3TII ANP 6.05263
69 4R78 AMP 6.14887
70 5IUY BOG 6.19946
71 1ZTH ADP 6.20155
72 3RE4 TO1 6.20155
73 1ZP9 ATP 6.20155
74 3O5N BR0 6.25
75 2FGQ MLT 6.3253
76 3N8K D1X 6.39535
77 4O1P ANP 6.73854
78 4CS9 AMP 6.87831
79 2IF8 ADP 6.88705
80 4OAV ACP 7.00809
81 2QK4 ATP 7.27763
82 2YFB SIN 7.36434
83 3KMW ATP 7.75194
84 4RDL FUC GAL NDG FUC 7.79221
85 4P7U 1PS 8.03571
86 6GR0 F8W 8.04598
87 3HAV ATP 8.3612
88 4Z7X 3CX 8.40336
89 4FGC PQ0 8.48485
90 4XZ3 ACP 8.69565
91 2UYN 2KT 9.30233
92 3Q60 ATP 9.43396
93 4LRJ ANP 9.46746
94 4WW7 AMP 9.62567
95 4OGQ 7PH 9.67742
96 4O4Z N2O 9.74026
97 2PIE GLU LEU LYS TPO GLU ARG TYR 10.1449
98 3UDZ ADP 10.5121
99 6FL8 TIY 10.5121
100 6FL8 ADP 10.5121
101 1BO4 COA 10.7143
102 5OSW DIU 10.7817
103 5C03 AGS 10.8187
104 6AC9 ANP 11.0811
105 5CKW ANP 11.8598
106 1XX4 BAM 12.2605
107 1UUY PPI 12.5749
108 2WCU FUC 13.4228
109 2D5X L35 14.3836
110 4B1L FRU 15.1515
111 5F90 GLA GAL 15.3846
112 4FL3 ANP 16.1725
113 3EKK GS2 16.6124
114 4CYI ATP 16.7116
115 3BU5 ATP 16.9935
116 1IR3 ANP 16.9935
117 3VHE 42Q 17.2702
118 2G36 TRP 17.3529
119 5KEW 6SB 18.75
120 4XH0 ADP 18.8679
121 1HFE CYS 19.5122
122 6C0T EE4 21.3256
123 6ES0 BW8 21.7666
124 5WNL STU 22.5146
125 3LQV ADE 23.0769
126 6GMN F4E 23.0769
127 5VC5 96M 23.5294
128 2CSN CKI 23.569
129 2PZI AXX 23.7197
130 1ONI BEZ 23.913
131 4PNI KQQ 24.2588
132 4Q5H ANP 25
133 5T8O 76Z 26.0745
134 4L9I 8PR 26.1905
135 4KBA 1QM 26.284
136 5W4W 9WG 26.284
137 6BFN DL1 26.3158
138 3C1X CKK 26.4151
139 5DMZ ADP 26.5753
140 3V8S 0HD 26.6846
141 3E8N VRA 26.6862
142 3E8N ATP 26.6862
143 2F2U M77 26.9542
144 4Y93 746 26.9542
145 3TXO 07U 27.1955
146 3PVW QRX 27.4933
147 5UKL SIX 27.4933
148 5KO1 6UY 27.5618
149 5VCV 1N1 27.6527
150 4UAL 3FV 27.7628
151 4WNK 453 27.7628
152 4BTK DTQ 27.8932
153 4Y8D 49J 27.9412
154 3H9R TAK 28.1818
155 4G17 0VN 28.1818
156 3UIM ANP 28.2209
157 4E93 GUI 28.3019
158 6BXI ANP 28.5285
159 4U44 3D9 28.6145
160 4OTH DRN 29.0323
161 6GZD LCI 29.1105
162 4X7Q 3YR 29.1667
163 5N87 N66 29.393
164 3LXN MI1 29.5597
165 4OH4 ANP 29.7297
166 3SLS ANP 29.9342
167 2OO8 RAJ 29.9685
168 5LPZ ADP 30.1205
169 3DLS ADP 30.1493
170 3LXK MI1 30.2752
171 5Y80 IRE 30.3514
172 3M2W L8I 30.4348
173 4N70 2HX 30.4878
174 4YMJ 4EJ 30.5921
175 5EOB 5QQ 30.721
176 1XJD STU 30.7246
177 4NFN 2KC 30.7443
178 6GIN IR2 30.897
179 5HES 032 30.9446
180 4M69 ANP 30.9904
181 4EUU BX7 31.0345
182 5NKB 8ZT 31.0458
183 1JPA ANP 31.0897
184 4BHN BH9 31.1377
185 5AX9 4KT 31.1688
186 4Y0X ADP 31.2
187 5OKT 9XK 31.2102
188 5UIU 8CG 31.2694
189 1BYG STU 31.295
190 5HVJ ANP 31.4286
191 2X2M X2M 31.5287
192 5Z84 CHD 31.7647
193 5ZCO CHD 31.7647
194 4AT3 LTI 31.7726
195 4GJ3 0XP 31.7881
196 4DC2 ADE 31.8059
197 4QMN DB8 31.9355
198 1VJY 460 32.0132
199 5M06 ADP 32.2464
200 3NW7 LGV 32.2476
201 3PP0 03Q 32.2485
202 2WQN ADP 32.2581
203 4EWH T77 32.3636
204 1U59 STU 32.4042
205 1U5R ATP 32.4713
206 3CY2 MB9 32.4841
207 3TKI S25 32.5077
208 2HY0 306 32.6087
209 5HCY 60D 32.6284
210 2Y6O 1N1 32.646
211 4E1Z 0MX 32.646
212 5MJA 7O3 32.7869
213 5TO8 7FM 32.9787
214 4CLI 5P8 33.0275
215 1K3A ACP 33.1104
216 3KRL KRL 33.1343
217 3VRY B43 33.1536
218 3GGF GVD 33.2226
219 6GQM F8H 33.2317
220 4U0I 0LI 33.3333
221 6CMJ F6J 33.3333
222 4ITH RCM 33.3333
223 5LPB ADP 33.4459
224 6C7Y ADP 33.5664
225 3SXS PP2 33.5821
226 6A1G 9OL 33.6111
227 3BZ3 YAM 33.6957
228 4ASE AV9 33.711
229 5WO4 B7V 33.7748
230 2R5T ANP 33.7802
231 4YZN 4K5 33.7979
232 6GWR FEW 33.9683
233 6CQF F97 34.0067
234 2PVF ACP 34.1317
235 1OPK P16 34.2318
236 6F3G CJN 34.2373
237 1ZY5 ANP 34.3234
238 4I6H 1C8 34.4156
239 3SRV S19 34.657
240 2QLU ADE 34.7134
241 5QIN J2V 34.8101
242 4P5Z Q7M 34.903
243 6E2O S0L 34.9153
244 4F4P 0SB 35.1648
245 5JKG 6LF 35.3698
246 3PLS ANP 35.5705
247 5EH0 5NW 35.6589
248 2ZV2 609 35.906
249 4NW6 2NS 35.9133
250 2A19 ANP 35.9155
251 5CEO 50D 36
252 5JFS 6K0 36.039
253 3GNI ATP 36.1186
254 4UXL 5P8 36.3354
255 2XVD AS6 36.4238
256 4IDT T28 36.5169
257 5FBN 5WF 36.5314
258 4A4X JUP 36.5591
259 2YAB AMP 36.5651
260 5JGA 6KC 36.8254
261 4C2V YJA 36.8421
262 3ORK AGS 36.9775
263 2Z7R STU 37.0717
264 2OFV 242 37.1841
265 4RFM 3P6 37.218
266 3MVH WFE 37.4269
267 2H8H H8H 37.4663
268 4YZC STU 37.4663
269 1Y57 MPZ 37.4663
270 5DBX ANP 37.5
271 4C2W ANP 37.6344
272 4AG8 AXI 37.6582
273 3IGO ANP 37.7358
274 4WB7 ATP 37.7358
275 4ONA UW1 38.0054
276 5EYK 5U5 38.0435
277 5U6C 7YS 38.0952
278 5LI1 ANP 38.1356
279 5H2U 1N1 38.2022
280 3ALN ANP 38.2263
281 3HZT J60 38.2749
282 3GQI ACP 38.3436
283 3C0G 3AM 38.4615
284 4K33 ACP 38.4615
285 5LI9 ACP 38.5714
286 6CZ3 FLJ 38.6364
287 4BFM ANP 38.9222
288 4WNP 3RJ 39.0244
289 5G1X ADP 39.2982
290 5L8L ADP 39.2982
291 2RIO ADP 39.3531
292 5LXM ADP 39.576
293 2V7O DRN 39.5833
294 3FC2 IBI 39.7015
295 1Q8Y ADE 39.8922
296 2WU6 DKI 39.8922
297 1Q8Y ADP 39.8922
298 5MY8 RXZ 39.8922
299 2QCS ANP 40
300 5UR1 YY9 40.1929
301 1RE8 BD2 40.2857
302 3IDB ANP 40.2857
303 3FHI ANP 40.2857
304 3HMO STU 40.3509
305 4WB6 ATP 40.5714
306 3RI1 3RH 40.5751
307 5ODT ADP 40.636
308 4CSV STI 40.7273
309 4XV1 904 40.7534
310 4Y85 499 40.9639
311 2HK5 1BM 41.1111
312 5IH9 6BF 41.194
313 5EW9 5VC 41.3284
314 5LVP ATP 41.4791
315 4CRL C1I 41.5094
316 5ZTN CUR 41.5094
317 5UPK ANP 41.6185
318 3E5A VX6 41.791
319 2GU8 796 41.8398
320 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 42.1053
321 2JDR L20 42.1053
322 4G31 0WH 42.1405
323 6FYL 3NG 42.1488
324 2VZ6 FEF 42.1725
325 5TA6 79D 42.1788
326 4TWP AXI 42.4354
327 3RWP ABQ 42.4437
328 3KN5 ANP 42.4615
329 2J7T 274 42.7152
330 4CQE CQE 42.8058
331 5Y86 HRM 42.8571
332 3FHR P4O 42.8571
333 5DRB 5FJ 42.9553
334 4I94 ANP 43
335 4JR7 GNP 43.3155
336 1PHK ATP 43.6242
337 4FG8 ATP 43.8095
338 2WEL K88 44.0367
339 4L3L 5FI 44.4079
340 4F9C 0SX 44.5983
341 4NST ADP 45.0142
342 4USF 6UI 45.0658
343 4IJP 1EH 45.5307
344 5EFQ ADP 45.5331
345 3G5D 1N1 45.8042
346 6FYV 3NG 45.9941
347 3F7Z 34O 46
348 1O9U ADZ 46.2857
349 2YAK OSV 46.3158
350 3DAK ANP 46.8966
351 3ZRM ZRM 46.9003
352 4KS7 X4Z 46.9178
353 2F57 23D 47.0032
354 2WEI VGG 47.0383
355 5X8I SQZ 47.1098
356 4NM5 ADP 47.1698
357 2JLD AG1 47.1698
358 5JZJ AN2 47.8114
359 5DEY 59T 47.8114
360 2VN9 GVD 48.1728
361 3GC0 AMP 48.3283
362 6G33 5ID 48.3776
363 5A6N U7E 48.4099
364 2XK9 XK9 48.4472
365 5XVG 8FX 49.1468
366 3PE2 E1B 49.5549
367 5HQ0 LZ9 49.6689
368 6GU6 1QK 49.6689
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