Receptor
PDB id Resolution Class Description Source Keywords
4EYJ 2.1 Å EC: 2.7.11.24 MAPK13 COMPLEX WITH INHIBITOR HOMO SAPIENS P38 FAMILY KINASE MAP KINASE TRANSFERASE-TRANSFERASE INHIBCOMPLEX
Ref.: IL-13-INDUCED AIRWAY MUCUS PRODUCTION IS ATTENUATED MAPK13 INHIBITION. J.CLIN.INVEST. V. 122 4555 2012
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
N61 A:401;
Valid;
none;
submit data
365.429 C20 H23 N5 O2 CC(C)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5EKO 2 Å EC: 2.7.11.24 CRYSTAL STRUCTURE OF MAPK13 COMPLEX WITH INHIBITOR HOMO SAPIENS KINASE TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: FIRST COMPREHENSIVE STRUCTURAL AND BIOPHYSICAL ANAL MAPK13 INHIBITORS TARGETING DFG-IN AND DFG-OUT BIND MODES. BIOCHIM.BIOPHYS.ACTA V.1860 2335 2016
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 16 families.
1 4EYM - 0RX C21 H20 N4 O3 c1cc(ccc1N....
2 5EKO ic50 = 15785 nM N17 C22 H18 N4 O2 Cc1cn(cn1)....
3 4EYJ - N61 C20 H23 N5 O2 CC(C)(C)c1....
70% Homology Family (155)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 3GCV Kd = 74 nM SS6 C29 H30 N8 O Cc1cccc(c1....
2 3L8S Kd = 99 nM BFF C20 H24 Br F2 N5 O3 S c1c(cc(c(c....
3 3RIN ic50 = 1.3 nM I2O C23 H24 N2 O2 Cc1ccc(cc1....
4 5N65 - 8OT C20 H18 N4 S c1ccc(cc1)....
5 4FA2 - SB0 C20 H21 F N4 O2 COc1nccc(n....
6 2GHM - LIC C24 H28 Cl N5 O3 C[C@@H](C(....
7 1W84 ic50 = 35 uM L12 C15 H14 N2 c1ccc2c(c1....
8 4EH5 - IRG C17 H16 N4 c1ccc(cc1)....
9 2BAK Kd = 37 nM AQZ C32 H37 N7 O4 Cc1ccc(cc1....
10 3HV6 ic50 = 5500 nM R39 C27 H35 N5 O3 Cc1ccc(cc1....
11 3HP2 - P36 C19 H16 Br N O2 c1ccc(cc1)....
12 1WBO ic50 = 1 mM 2CH C6 H5 Cl O c1ccc(c(c1....
13 4KIQ ic50 = 23 nM 1RA C23 H23 N3 O4 CCOC(=O)n1....
14 3GC7 ic50 = 0.4 nM B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
15 4EH6 - IRG C17 H16 N4 c1ccc(cc1)....
16 5MTX Kd = 17.7 nM FJI C34 H31 F N4 O5 c1ccc(cc1)....
17 2ZB0 Ki = 0.24 uM GK3 C24 H18 N4 O2 Cc1ccc(cc1....
18 2GTM ic50 = 542 nM LID C19 H15 Cl F2 N6 CCn1c2c(cn....
19 5N66 - B96 C31 H37 N5 O3 Cc1ccc(cc1....
20 2YIX Kd = 3.3 nM YIX C19 H23 N5 O S CCNC(=O)NC....
21 3OCG ic50 = 3 nM OCG C21 H18 N6 O3 Cc1ccc(cc1....
22 1BL7 - SB4 C18 H19 F N6 c1cc(ccc1c....
23 3P7C ic50 = 0.022 uM P7C C25 H33 Cl2 N5 O3 S CC(C)(C)c1....
24 5TBE Kd = 4.4 nM 78L C33 H30 F2 N4 O4 S c1cc(sc1)C....
25 4KIP ic50 = 7 nM 1R9 C21 H18 Cl N3 O2 S Cc1ccc(cc1....
26 2EWA - SB2 C21 H16 F N3 O S C[S@](=O)c....
27 2GHL - LIB C23 H26 Cl N5 O3 C[C@@H](C(....
28 1ZZ2 ic50 = 6 uM B11 C24 H26 F N3 O4 S c1ccc(c(c1....
29 3ZSI - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
30 2YIW - YIW C30 H33 N7 O S CC(C)c1nnc....
31 1A9U - SB2 C21 H16 F N3 O S C[S@](=O)c....
32 1M7Q ic50 = 2.6 nM DQO C24 H20 Cl2 F2 N4 O c1cc(c(c(c....
33 5MTY Kd = 1.3 nM HB9 C29 H23 F2 N3 O4 S c1cc(sc1)C....
34 4EH7 - IRG C17 H16 N4 c1ccc(cc1)....
35 1YQJ ic50 = 7.3 nM 6NP C30 H27 N5 c1ccc(cc1)....
36 4EH3 - NAR C15 H12 O5 c1cc(ccc1[....
37 4AA5 ic50 = 6.7 nM NQB C24 H27 N5 O2 Cc1ccc(cc1....
38 1OVE ic50 = 0.74 nM 358 C26 H22 Cl2 F2 N2 O c1cc(c(c(c....
39 3UVP ic50 = 0.035 uM 048 C24 H21 F N2 O2 c1ccc(cc1)....
40 5N67 - 8ON C28 H30 N6 O CC(=O)N1CC....
41 3NNV ic50 = 27 nM 437 C25 H26 N4 O2 CC(C)(C)c1....
42 3CTQ ic50 = 40 nM 337 C30 H34 N6 O5 S Cc1ccc(cc1....
43 3IW7 - IPK C26 H26 N4 O S c1ccc(cc1)....
44 3ITZ ic50 = 1.4 nM P66 C21 H15 Cl F2 N6 O c1cc(c(c(c....
45 2ZB1 Ki = 0.48 uM GK4 C21 H21 N3 O2 Cc1ccc(cc1....
46 3HV5 ic50 = 150 nM R24 C30 H29 N7 O3 Cc1ccc(cc1....
47 1WBW ic50 = 44 uM LI4 C16 H14 N2 O c1ccc2c(c1....
48 3P79 ic50 = 2.3 uM P79 C24 H29 N5 O4 S CC(C)(C)c1....
49 3HV7 ic50 = 90 nM 1AU C24 H25 N5 O CC(C)(C)c1....
50 3GFE ic50 = 3.2 nM P37 C24 H21 F2 N5 O2 Cc1ccc(cc1....
51 3ZYA - 2A8 C21 H18 N2 O c1ccc2c(c1....
52 2RG5 ic50 = 3.1 nM 279 C19 H22 N6 O3 CCNC(=O)c1....
53 3L8X ic50 = 10 nM N4D C20 H18 N6 O Cc1ccc(cc1....
54 3GCS Kd = 56 nM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
55 3ZS5 - SB2 C21 H16 F N3 O S C[S@](=O)c....
56 3D83 Ki = 4.4 nM GK6 C28 H30 N4 O3 Cc1ccc(cc1....
57 1YW2 ic50 = 141 nM PGJ C22 H18 F N3 O5 CCOC[N@]1C....
58 1W82 ic50 = 196 nM L10 C20 H21 Cl N4 O CC(C)(C)C1....
59 3ZSG - T75 C24 H21 N3 O S CCc1nc(c(s....
60 5TCO Kd = 3.14 nM 79Q C35 H33 F N4 O4 c1ccc(cc1)....
61 4EH8 - IRG C17 H16 N4 c1ccc(cc1)....
62 3GCP Kd = 15 nM SB2 C21 H16 F N3 O S C[S@](=O)c....
63 3HLL Ki = 0.0058 uM I45 C22 H19 Br F2 N2 O3 Cc1ccc(cc1....
64 1ZZL ic50 = 5 nM TZY C18 H15 F N4 O CC(C)c1nnc....
65 2RG6 ic50 = 2.2 nM 287 C25 H26 N6 O3 Cc1ccc(cc1....
66 3MPT ic50 = 0.25 uM 1GK C18 H16 N2 O3 Cc1ccccc1C....
67 1BL6 - SB6 C18 H16 F N3 c1cc(ccc1c....
68 3NNW ic50 = 9 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
69 3GI3 Kd < 1.8 nM B10 C33 H39 N5 O5 S CC(C)(C)c1....
70 3K3J - I46 C14 H9 F2 N3 c1cc(ccc1c....
71 3HEC ic50 = 70 uM STI C29 H31 N7 O Cc1ccc(cc1....
72 1IAN - D13 C21 H16 I N3 O S C[S@@](=O)....
73 3FC1 - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
74 3MVM ic50 = 13 nM 39P C22 H23 N7 O3 CCCNC(=O)c....
75 3NNU ic50 = 48 nM EDB C22 H17 Cl2 N5 O2 S c1cc(cc(c1....
76 1W7H ic50 = 1 mM 3IP C12 H12 N2 O c1ccc(cc1)....
77 3U8W ic50 = 1 nM 09J C24 H21 Cl F N5 O2 CCN1C(=O)C....
78 1WBS ic50 = 0.63 uM LI2 C26 H25 F N4 O2 c1cc2c(cc1....
79 4E6C Kd ~ 15 uM 0O8 C25 H53 N O4 P CCCCCCCCCC....
80 5N68 - 8OK C26 H27 N5 O c1ccc(cc1)....
81 1WBV ic50 = 162 uM LI3 C19 H18 F N3 O2 c1cc2c(cc[....
82 4EH2 - IRG C17 H16 N4 c1ccc(cc1)....
83 3HA8 - 5JZ C36 H38 N8 O5 CCOc1nc(nc....
84 3HEG ic50 = 0.057 uM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
85 2ZAZ Ki = 0.4 uM GK1 C20 H15 N3 O2 S Cc1ccc(cc1....
86 3HP5 - I46 C14 H9 F2 N3 c1cc(ccc1c....
87 5ML5 ic50 = 10 nM 1VI C26 H25 F N4 O3 S COc1ccc(c(....
88 4DLI Kd = 2.4 uM IRG C17 H16 N4 c1ccc(cc1)....
89 3P78 ic50 = 0.11 uM P78 C24 H27 N3 O4 S2 CC(C)(C)c1....
90 4EH9 - IRG C17 H16 N4 c1ccc(cc1)....
91 1YWR ic50 = 32 nM LI9 C27 H29 F N6 O C[C@@H](c1....
92 3IW5 Kd = 0.839 uM DF3 C28 H24 F3 N3 O4 S c1ccc2c(c1....
93 3HV3 ic50 = 900 nM R49 C30 H31 N7 O Cc1cccc(c1....
94 4A9Y - RNY C32 H37 N7 O4 Cc1ccc(cc1....
95 3GCU - R48 C29 H30 N8 O Cc1ccc(cc1....
96 1OUY ic50 = 4.3 nM 094 C24 H18 Cl2 F2 N4 O S c1cc(c(c(c....
97 3D7Z Ki = 12 nM GK5 C22 H24 N2 O2 Cc1ccc(cc1....
98 2YIS - YIS C35 H34 Cl N7 O3 S2 CC(C)(C)c1....
99 1OUK ic50 = 0.13 nM 084 C28 H29 F3 N6 C[C@@H](c1....
100 3BV2 Ki = 0.44 nM P38 C33 H32 N8 O3 Cc1ccc(cc1....
101 4R3C - GG5 C14 H10 F N3 c1cc(ccc1c....
102 4L8M ic50 = 0.001 uM F46 C33 H30 F N3 O5 c1ccc(cc1)....
103 4E6A - 0O9 C32 H65 O10 P CCCCCCCCCC....
104 1WBN ic50 = 0.35 uM L09 C20 H22 Cl N5 O2 CC(C)(C)c1....
105 2QD9 ic50 = 13 nM LGF C27 H24 F2 N6 O5 COC1=NC2=N....
106 3HUC Kd = 1030 nM G97 C20 H16 N6 O C=CC(=O)Nc....
107 3HL7 Ki = 0.023 uM I47 C20 H20 Cl N5 O2 c1cc(ccc1c....
108 4EHV - IRG C17 H16 N4 c1ccc(cc1)....
109 2GTN ic50 = 4 nM LIE C20 H16 F3 N5 O CC(C)n1c2c....
110 3HRB ic50 = 21 nM I39 C19 H14 F2 N2 O2 Cc1ccccc1c....
111 3BX5 ic50 = 1.5 nM 304 C17 H22 N4 O2 S CC[C@@H](C....
112 3HVC ic50 = 600 nM GG5 C14 H10 F N3 c1cc(ccc1c....
113 2GFS ic50 = 0.7 uM PQB C19 H18 F N3 O4 c1cc(cc(c1....
114 5N63 - 8OW C21 H17 F N4 c1ccc(cc1)....
115 2NPQ Kd = 3.08 uM BOG C14 H28 O6 CCCCCCCCO[....
116 3IW6 Kd = 3.29 uM PP0 C23 H31 N3 O3 CCn1c(c(c(....
117 3S4Q ic50 = 4 nM NK0 C25 H23 N5 O2 Cc1ccc(cc1....
118 2BAJ Kd = 4 nM 1PP C20 H20 Cl2 N4 O CC(C)(C)c1....
119 3ROC - 29B C14 H10 F N3 c1cc(ccc1c....
120 3NWW ic50 = 7 nM 3NW C24 H34 N8 O S CCNC(=O)NC....
121 1W83 ic50 = 0.065 uM L11 C23 H25 Cl F N3 O3 c1cc(cnc1)....
122 3ZSH - 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
123 3IPH Ki = 0.0000251 mM G11 C21 H23 N3 O2 Cc1ccc(cc1....
124 3P7B ic50 = 0.018 uM P7B C25 H28 N4 O3 S CC(C)(C)c1....
125 3GCQ Kd = 342 nM 1BU C29 H30 N8 O Cc1cccc(c1....
126 4F9Y Ki = 184 nM LM3 C21 H18 N4 CN(C)c1cc(....
127 2BAL Kd = 490 nM PQA C21 H21 F N4 O2 c1cc(cc(c1....
128 3HUB Kd = 8.2 nM 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
129 4F9W Ki = 114 nM LM4 C21 H18 N4 CN(C)c1cc(....
130 3P5K ic50 = 0.076 uM P5K C24 H27 N3 O4 S2 CC(C)(C)c1....
131 2I0H ic50 = 9 nM 222 C27 H19 Cl2 F N4 O3 c1ccc2c(c1....
132 1ZYJ ic50 = 1.5 uM BI5 C19 H16 N2 O2 c1ccc(cc1)....
133 3K3I - JZJ C18 H16 Br N3 c1ccc2c(c1....
134 1WBT ic50 = 0.34 uM WBT C26 H25 F N4 O2 c1cc(cc2c1....
135 1BMK - SB5 C17 H16 F N5 c1cc(ccc1c....
136 3E92 Ki = 10 nM G6A C21 H21 N3 O2 Cc1ccc(cc1....
137 3P7A ic50 = 0.52 uM P7A C23 H27 N3 O3 S2 CC(C)(C)c1....
138 3NNX ic50 = 11 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
139 4EH4 - IRG C17 H16 N4 c1ccc(cc1)....
140 1KV1 Kd = 1.16 uM BMU C15 H19 Cl N4 O CC(C)(C)c1....
141 3KF7 ic50 = 40 nM L9G C22 H18 F2 N4 O Cc1ccc(cc1....
142 4KIN ic50 = 4.8 nM 1M8 C22 H19 Cl N2 O2 S Cc1ccc(cc1....
143 4AA4 ic50 = 9 nM QC0 C25 H25 N5 O3 Cc1ccc(cc1....
144 3E93 Ki = 1.4 nM 19B C30 H32 N4 O3 Cc1ccc(cc1....
145 4AAC ic50 = 16 nM AAV C24 H24 N6 O3 Cc1ccc(cc1....
146 4AA0 ic50 = 35 nM AA0 C30 H33 N7 O3 Cc1ccc(cc1....
147 1OZ1 ic50 = 6.5 nM FPH C18 H12 F N3 O c1cc2c(c(c....
148 5N64 - 8OH C19 H16 N4 S c1ccc(cc1)....
149 3IW8 Kd = 13.4 uM HIZ C19 H18 Cl F N4 O2 S c1ccc(cc1)....
150 3GC8 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
151 3GC9 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
152 4EYM - 0RX C21 H20 N4 O3 c1cc(ccc1N....
153 5EKO ic50 = 15785 nM N17 C22 H18 N4 O2 Cc1cn(cn1)....
154 4EYJ - N61 C20 H23 N5 O2 CC(C)(C)c1....
155 1CM8 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
50% Homology Family (257)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 3GCV Kd = 74 nM SS6 C29 H30 N8 O Cc1cccc(c1....
2 3L8S Kd = 99 nM BFF C20 H24 Br F2 N5 O3 S c1c(cc(c(c....
3 3RIN ic50 = 1.3 nM I2O C23 H24 N2 O2 Cc1ccc(cc1....
4 5N65 - 8OT C20 H18 N4 S c1ccc(cc1)....
5 4FA2 - SB0 C20 H21 F N4 O2 COc1nccc(n....
6 2GHM - LIC C24 H28 Cl N5 O3 C[C@@H](C(....
7 1W84 ic50 = 35 uM L12 C15 H14 N2 c1ccc2c(c1....
8 4EH5 - IRG C17 H16 N4 c1ccc(cc1)....
9 2BAK Kd = 37 nM AQZ C32 H37 N7 O4 Cc1ccc(cc1....
10 3HV6 ic50 = 5500 nM R39 C27 H35 N5 O3 Cc1ccc(cc1....
11 3HP2 - P36 C19 H16 Br N O2 c1ccc(cc1)....
12 1WBO ic50 = 1 mM 2CH C6 H5 Cl O c1ccc(c(c1....
13 4KIQ ic50 = 23 nM 1RA C23 H23 N3 O4 CCOC(=O)n1....
14 3GC7 ic50 = 0.4 nM B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
15 4EH6 - IRG C17 H16 N4 c1ccc(cc1)....
16 5MTX Kd = 17.7 nM FJI C34 H31 F N4 O5 c1ccc(cc1)....
17 2ZB0 Ki = 0.24 uM GK3 C24 H18 N4 O2 Cc1ccc(cc1....
18 2GTM ic50 = 542 nM LID C19 H15 Cl F2 N6 CCn1c2c(cn....
19 5N66 - B96 C31 H37 N5 O3 Cc1ccc(cc1....
20 2YIX Kd = 3.3 nM YIX C19 H23 N5 O S CCNC(=O)NC....
21 3OCG ic50 = 3 nM OCG C21 H18 N6 O3 Cc1ccc(cc1....
22 1BL7 - SB4 C18 H19 F N6 c1cc(ccc1c....
23 3P7C ic50 = 0.022 uM P7C C25 H33 Cl2 N5 O3 S CC(C)(C)c1....
24 5TBE Kd = 4.4 nM 78L C33 H30 F2 N4 O4 S c1cc(sc1)C....
25 4KIP ic50 = 7 nM 1R9 C21 H18 Cl N3 O2 S Cc1ccc(cc1....
26 2EWA - SB2 C21 H16 F N3 O S C[S@](=O)c....
27 2GHL - LIB C23 H26 Cl N5 O3 C[C@@H](C(....
28 1ZZ2 ic50 = 6 uM B11 C24 H26 F N3 O4 S c1ccc(c(c1....
29 3ZSI - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
30 2YIW - YIW C30 H33 N7 O S CC(C)c1nnc....
31 1A9U - SB2 C21 H16 F N3 O S C[S@](=O)c....
32 1M7Q ic50 = 2.6 nM DQO C24 H20 Cl2 F2 N4 O c1cc(c(c(c....
33 5MTY Kd = 1.3 nM HB9 C29 H23 F2 N3 O4 S c1cc(sc1)C....
34 4EH7 - IRG C17 H16 N4 c1ccc(cc1)....
35 1YQJ ic50 = 7.3 nM 6NP C30 H27 N5 c1ccc(cc1)....
36 4EH3 - NAR C15 H12 O5 c1cc(ccc1[....
37 4AA5 ic50 = 6.7 nM NQB C24 H27 N5 O2 Cc1ccc(cc1....
38 1OVE ic50 = 0.74 nM 358 C26 H22 Cl2 F2 N2 O c1cc(c(c(c....
39 3UVP ic50 = 0.035 uM 048 C24 H21 F N2 O2 c1ccc(cc1)....
40 5N67 - 8ON C28 H30 N6 O CC(=O)N1CC....
41 3NNV ic50 = 27 nM 437 C25 H26 N4 O2 CC(C)(C)c1....
42 3CTQ ic50 = 40 nM 337 C30 H34 N6 O5 S Cc1ccc(cc1....
43 3IW7 - IPK C26 H26 N4 O S c1ccc(cc1)....
44 3ITZ ic50 = 1.4 nM P66 C21 H15 Cl F2 N6 O c1cc(c(c(c....
45 2ZB1 Ki = 0.48 uM GK4 C21 H21 N3 O2 Cc1ccc(cc1....
46 3HV5 ic50 = 150 nM R24 C30 H29 N7 O3 Cc1ccc(cc1....
47 1WBW ic50 = 44 uM LI4 C16 H14 N2 O c1ccc2c(c1....
48 3P79 ic50 = 2.3 uM P79 C24 H29 N5 O4 S CC(C)(C)c1....
49 3HV7 ic50 = 90 nM 1AU C24 H25 N5 O CC(C)(C)c1....
50 3GFE ic50 = 3.2 nM P37 C24 H21 F2 N5 O2 Cc1ccc(cc1....
51 3ZYA - 2A8 C21 H18 N2 O c1ccc2c(c1....
52 2RG5 ic50 = 3.1 nM 279 C19 H22 N6 O3 CCNC(=O)c1....
53 3L8X ic50 = 10 nM N4D C20 H18 N6 O Cc1ccc(cc1....
54 3GCS Kd = 56 nM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
55 3ZS5 - SB2 C21 H16 F N3 O S C[S@](=O)c....
56 3D83 Ki = 4.4 nM GK6 C28 H30 N4 O3 Cc1ccc(cc1....
57 1YW2 ic50 = 141 nM PGJ C22 H18 F N3 O5 CCOC[N@]1C....
58 1W82 ic50 = 196 nM L10 C20 H21 Cl N4 O CC(C)(C)C1....
59 3ZSG - T75 C24 H21 N3 O S CCc1nc(c(s....
60 5TCO Kd = 3.14 nM 79Q C35 H33 F N4 O4 c1ccc(cc1)....
61 4EH8 - IRG C17 H16 N4 c1ccc(cc1)....
62 3GCP Kd = 15 nM SB2 C21 H16 F N3 O S C[S@](=O)c....
63 3HLL Ki = 0.0058 uM I45 C22 H19 Br F2 N2 O3 Cc1ccc(cc1....
64 1ZZL ic50 = 5 nM TZY C18 H15 F N4 O CC(C)c1nnc....
65 2RG6 ic50 = 2.2 nM 287 C25 H26 N6 O3 Cc1ccc(cc1....
66 3MPT ic50 = 0.25 uM 1GK C18 H16 N2 O3 Cc1ccccc1C....
67 1BL6 - SB6 C18 H16 F N3 c1cc(ccc1c....
68 3NNW ic50 = 9 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
69 3GI3 Kd < 1.8 nM B10 C33 H39 N5 O5 S CC(C)(C)c1....
70 3K3J - I46 C14 H9 F2 N3 c1cc(ccc1c....
71 3HEC ic50 = 70 uM STI C29 H31 N7 O Cc1ccc(cc1....
72 1IAN - D13 C21 H16 I N3 O S C[S@@](=O)....
73 3FC1 - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
74 3MVM ic50 = 13 nM 39P C22 H23 N7 O3 CCCNC(=O)c....
75 3NNU ic50 = 48 nM EDB C22 H17 Cl2 N5 O2 S c1cc(cc(c1....
76 1W7H ic50 = 1 mM 3IP C12 H12 N2 O c1ccc(cc1)....
77 3U8W ic50 = 1 nM 09J C24 H21 Cl F N5 O2 CCN1C(=O)C....
78 1WBS ic50 = 0.63 uM LI2 C26 H25 F N4 O2 c1cc2c(cc1....
79 4E6C Kd ~ 15 uM 0O8 C25 H53 N O4 P CCCCCCCCCC....
80 5N68 - 8OK C26 H27 N5 O c1ccc(cc1)....
81 1WBV ic50 = 162 uM LI3 C19 H18 F N3 O2 c1cc2c(cc[....
82 4EH2 - IRG C17 H16 N4 c1ccc(cc1)....
83 3HA8 - 5JZ C36 H38 N8 O5 CCOc1nc(nc....
84 3HEG ic50 = 0.057 uM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
85 2ZAZ Ki = 0.4 uM GK1 C20 H15 N3 O2 S Cc1ccc(cc1....
86 3HP5 - I46 C14 H9 F2 N3 c1cc(ccc1c....
87 5ML5 ic50 = 10 nM 1VI C26 H25 F N4 O3 S COc1ccc(c(....
88 4DLI Kd = 2.4 uM IRG C17 H16 N4 c1ccc(cc1)....
89 3P78 ic50 = 0.11 uM P78 C24 H27 N3 O4 S2 CC(C)(C)c1....
90 4EH9 - IRG C17 H16 N4 c1ccc(cc1)....
91 1YWR ic50 = 32 nM LI9 C27 H29 F N6 O C[C@@H](c1....
92 3IW5 Kd = 0.839 uM DF3 C28 H24 F3 N3 O4 S c1ccc2c(c1....
93 3HV3 ic50 = 900 nM R49 C30 H31 N7 O Cc1cccc(c1....
94 4A9Y - RNY C32 H37 N7 O4 Cc1ccc(cc1....
95 3GCU - R48 C29 H30 N8 O Cc1ccc(cc1....
96 1OUY ic50 = 4.3 nM 094 C24 H18 Cl2 F2 N4 O S c1cc(c(c(c....
97 3D7Z Ki = 12 nM GK5 C22 H24 N2 O2 Cc1ccc(cc1....
98 2YIS - YIS C35 H34 Cl N7 O3 S2 CC(C)(C)c1....
99 1OUK ic50 = 0.13 nM 084 C28 H29 F3 N6 C[C@@H](c1....
100 3BV2 Ki = 0.44 nM P38 C33 H32 N8 O3 Cc1ccc(cc1....
101 4R3C - GG5 C14 H10 F N3 c1cc(ccc1c....
102 4L8M ic50 = 0.001 uM F46 C33 H30 F N3 O5 c1ccc(cc1)....
103 4E6A - 0O9 C32 H65 O10 P CCCCCCCCCC....
104 1WBN ic50 = 0.35 uM L09 C20 H22 Cl N5 O2 CC(C)(C)c1....
105 2QD9 ic50 = 13 nM LGF C27 H24 F2 N6 O5 COC1=NC2=N....
106 3HUC Kd = 1030 nM G97 C20 H16 N6 O C=CC(=O)Nc....
107 3HL7 Ki = 0.023 uM I47 C20 H20 Cl N5 O2 c1cc(ccc1c....
108 4EHV - IRG C17 H16 N4 c1ccc(cc1)....
109 2GTN ic50 = 4 nM LIE C20 H16 F3 N5 O CC(C)n1c2c....
110 3HRB ic50 = 21 nM I39 C19 H14 F2 N2 O2 Cc1ccccc1c....
111 3BX5 ic50 = 1.5 nM 304 C17 H22 N4 O2 S CC[C@@H](C....
112 3HVC ic50 = 600 nM GG5 C14 H10 F N3 c1cc(ccc1c....
113 2GFS ic50 = 0.7 uM PQB C19 H18 F N3 O4 c1cc(cc(c1....
114 5N63 - 8OW C21 H17 F N4 c1ccc(cc1)....
115 2NPQ Kd = 3.08 uM BOG C14 H28 O6 CCCCCCCCO[....
116 3IW6 Kd = 3.29 uM PP0 C23 H31 N3 O3 CCn1c(c(c(....
117 3S4Q ic50 = 4 nM NK0 C25 H23 N5 O2 Cc1ccc(cc1....
118 2BAJ Kd = 4 nM 1PP C20 H20 Cl2 N4 O CC(C)(C)c1....
119 3ROC - 29B C14 H10 F N3 c1cc(ccc1c....
120 3NWW ic50 = 7 nM 3NW C24 H34 N8 O S CCNC(=O)NC....
121 1W83 ic50 = 0.065 uM L11 C23 H25 Cl F N3 O3 c1cc(cnc1)....
122 3ZSH - 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
123 3IPH Ki = 0.0000251 mM G11 C21 H23 N3 O2 Cc1ccc(cc1....
124 3P7B ic50 = 0.018 uM P7B C25 H28 N4 O3 S CC(C)(C)c1....
125 3GCQ Kd = 342 nM 1BU C29 H30 N8 O Cc1cccc(c1....
126 4F9Y Ki = 184 nM LM3 C21 H18 N4 CN(C)c1cc(....
127 2BAL Kd = 490 nM PQA C21 H21 F N4 O2 c1cc(cc(c1....
128 3HUB Kd = 8.2 nM 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
129 4F9W Ki = 114 nM LM4 C21 H18 N4 CN(C)c1cc(....
130 3P5K ic50 = 0.076 uM P5K C24 H27 N3 O4 S2 CC(C)(C)c1....
131 2I0H ic50 = 9 nM 222 C27 H19 Cl2 F N4 O3 c1ccc2c(c1....
132 1ZYJ ic50 = 1.5 uM BI5 C19 H16 N2 O2 c1ccc(cc1)....
133 3K3I - JZJ C18 H16 Br N3 c1ccc2c(c1....
134 1WBT ic50 = 0.34 uM WBT C26 H25 F N4 O2 c1cc(cc2c1....
135 1BMK - SB5 C17 H16 F N5 c1cc(ccc1c....
136 3E92 Ki = 10 nM G6A C21 H21 N3 O2 Cc1ccc(cc1....
137 3P7A ic50 = 0.52 uM P7A C23 H27 N3 O3 S2 CC(C)(C)c1....
138 3NNX ic50 = 11 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
139 4EH4 - IRG C17 H16 N4 c1ccc(cc1)....
140 1KV1 Kd = 1.16 uM BMU C15 H19 Cl N4 O CC(C)(C)c1....
141 3KF7 ic50 = 40 nM L9G C22 H18 F2 N4 O Cc1ccc(cc1....
142 4KIN ic50 = 4.8 nM 1M8 C22 H19 Cl N2 O2 S Cc1ccc(cc1....
143 4AA4 ic50 = 9 nM QC0 C25 H25 N5 O3 Cc1ccc(cc1....
144 3E93 Ki = 1.4 nM 19B C30 H32 N4 O3 Cc1ccc(cc1....
145 4AAC ic50 = 16 nM AAV C24 H24 N6 O3 Cc1ccc(cc1....
146 4AA0 ic50 = 35 nM AA0 C30 H33 N7 O3 Cc1ccc(cc1....
147 1OZ1 ic50 = 6.5 nM FPH C18 H12 F N3 O c1cc2c(c(c....
148 5N64 - 8OH C19 H16 N4 S c1ccc(cc1)....
149 3IW8 Kd = 13.4 uM HIZ C19 H18 Cl F N4 O2 S c1ccc(cc1)....
150 3TTI ic50 = 0.006 uM KBI C21 H23 F3 N6 O2 c1c(cc(c(c....
151 3TTJ ic50 = 0.21 uM JBI C23 H23 F N6 O COc1ccc(cc....
152 1JNK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
153 4H3B Kd = 17.2 uM VAL VAL ARG PRO GLY SER LEU ASP LEU PRO n/a n/a
154 3KVX ic50 = 0.148 uM FMY C26 H27 F N8 O2 c1cc(ccc1/....
155 4H39 Kd = 0.8 uM PRO LYS ARG PRO THR THR LEU ASN LEU PHE n/a n/a
156 4AWI ic50 = 1 uM AQ2 C21 H25 N3 O4 S2 CC(C)c1cc2....
157 2O0U ic50 = 3.2 uM C0M C27 H28 N4 O2 S c1ccc2c(c1....
158 2P33 ic50 = 57 nM J07 C20 H23 Cl N6 O CCNC(=O)N1....
159 2ZDU - 446 C28 H23 Br N2 O6 COC(=O)C1=....
160 2B1P ic50 = 3 nM AIZ C26 H26 Cl N5 O3 CN(C)CCCC(....
161 2OK1 Ki = 0.55 uM 33A C21 H17 Cl N4 O c1ccc(cc1)....
162 3OXI ic50 = 2.2 uM SYY C12 H11 N O3 S2 COC(=O)c1c....
163 3OY1 ic50 = 0.016 uM 589 C28 H31 N5 O2 c1ccc2cc(c....
164 2ZDT - 46C C26 H20 Cl N O4 CCC(=O)C1=....
165 3ELJ - GS7 C22 H21 F N6 O4 S COc1cc(ccc....
166 3FI2 ic50 = 0.025 uM JK1 C26 H25 N5 O5 COc1cc(cc(....
167 4L7F ic50 = 160 nM 1V5 C26 H26 F N5 O2 c1cc(ccc1C....
168 2WAJ ic50 = 0.398 uM SNB C16 H13 Br Cl N O COc1cc2c(c....
169 4QTD ic50 = 1080 nM 38Z C33 H33 N9 O2 c1cnc(nc1)....
170 3G9L Ki = 0.74 uM J67 C25 H19 F N2 O4 c1ccc(cc1)....
171 4Y46 ic50 = 11 nM 4F2 C22 H32 N6 O2 CC(C)NC(=O....
172 1PMN ic50 = 7.1 nM 984 C25 H30 Cl2 N6 CCCn1c(c(n....
173 3FI3 ic50 = 12 nM JK2 C29 H25 F N4 O4 COc1cc(cc(....
174 2O2U ic50 = 4 uM 738 C16 H13 F N2 O S c1ccc(c(c1....
175 4W4V ic50 = 866 nM 3H8 C23 H19 Cl N6 O2 Cc1cc(ccn1....
176 3DA6 - BZ9 C28 H23 N7 O Cc1cc(c2cc....
177 2R9S ic50 = 0.15 uM 255 C24 H24 N4 O2 S CC(C)(C)NS....
178 4Y5H ic50 = 15 nM 519 C20 H30 N6 O2 CC(C)NC(=O....
179 4X21 Kd = 36 nM 3WH C20 H23 I N6 O CCNC(=O)N1....
180 3RTP ic50 = 7 nM 34I C18 H14 N6 O2 S c1ccc2c(c1....
181 3PZE - CFK C12 H11 N3 O2 S c1ccc(cc1)....
182 4Z9L ic50 = 1.6 nM 880 C27 H34 Cl2 N6 CCCn1c(c(n....
183 4WHZ ic50 < 1 nM 3NL C24 H23 Cl N8 O2 c1ccc(c(c1....
184 4W4Y ic50 = 3034 nM 3HQ C24 H22 N6 O2 Cc1ccc(cc1....
185 4W4W ic50 = 6630 nM 3HJ C23 H20 N6 O2 Cc1cc(ccn1....
186 3G90 Ki = 0.44 uM J72 C17 H12 F2 N2 O4 c1cc2c(cc1....
187 1PMV ic50 = 150 nM 537 C14 H8 N2 O c1ccc2c(c1....
188 3GC8 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
189 3GC9 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
190 4ZSL - 4QZ C17 H17 Cl N6 O C[C@@H](c1....
191 5BYZ ic50 = 0.042 uM 4WE C25 H32 F N7 O Cc1ncc(n1C....
192 4ZSJ ic50 = 2.3 uM 4R0 C13 H17 Cl N6 O Cc1cc(ccc1....
193 4ZSG - 4QX C12 H15 Cl N6 O CC(C)NC(=O....
194 4XP3 - DX4 C5 H5 N5 S c1[nH]c2c(....
195 4O6E ic50 = 1 nM 2SH C21 H25 Cl F N5 O3 c1cc(c(cc1....
196 5NHJ ic50 < 0.0003 uM 8XE C18 H21 N7 O2 Cn1c(ccn1)....
197 4QYY Kd = 0.05 uM 3G7 C25 H29 Cl N4 O4 CC(=O)c1cc....
198 4I5H Ki < 2 nM G17 C26 H21 F3 N4 O Cc1ccc(cc1....
199 4QTE Kd = 0.084 uM 390 C24 H20 Cl2 F N5 O2 Cc1cnc(nc1....
200 4XNE - TT4 C8 H9 N5 c1ccc(cc1)....
201 3QYW - 6PB C11 H8 Br N5 c1cc(cc(c1....
202 5BUE ic50 = 0.003 uM 4V8 C23 H21 N5 O c1ccc(cc1)....
203 2Z7L - S91 C20 H19 N5 O3 Cc1cccc(c1....
204 4ZXT - CAQ C6 H6 O2 c1ccc(c(c1....
205 1WZY ic50 = 0.56 uM F29 C21 H17 N7 C=CCn1c2c(....
206 5NHH ic50 < 0.00113 uM 8XH C19 H25 N5 O3 COCCN1CCc2....
207 4N4S - 2H1 C25 H24 N6 O Cc1cc(cc2c....
208 4QP8 ic50 = 0.28 uM 362 C14 H10 N6 c1cc(cnc1)....
209 4QP4 - 36O C11 H15 N5 c1[nH]c2c(....
210 4QP9 ic50 = 0.071 uM 35X C17 H16 N6 CCCn1cc(cn....
211 5BVE ic50 = 0.01 nM 4VG C25 H28 Cl N5 O3 c1cc(cc(c1....
212 5KE0 - 6S9 C20 H18 N6 O Cc1cc(ccn1....
213 4XOY - DX4 C5 H5 N5 S c1[nH]c2c(....
214 3QYZ - Z8B C10 H11 Br N8 O3 c1nc(c2c(n....
215 5BVF ic50 = 0.19 nM 4VJ C25 H28 Cl N5 O3 c1cc(cc(c1....
216 4XOZ - 620 C15 H16 N6 O c1ccc(cc1)....
217 5HD7 - 38Z C33 H33 N9 O2 c1cnc(nc1)....
218 4XRJ - 620 C15 H16 N6 O c1ccc(cc1)....
219 2OJJ Ki = 0.002 uM 82A C22 H17 Cl2 F N4 O2 c1cc(cc(c1....
220 4QTA Kd = 0.013 uM 38Z C33 H33 N9 O2 c1cnc(nc1)....
221 5NHO ic50 < 0.0003 uM 8XN C20 H25 N7 O2 Cc1cnc(nc1....
222 2OJG Ki = 2.3 uM 19A C16 H16 N4 O CN(C)C(=O)....
223 4XP0 - 42A C8 H5 N3 c1cc2c(c[n....
224 4QP2 Kd = 940 uM 36R C7 H5 Cl N2 O c1cc2c(cc1....
225 5NHF ic50 = 0.0012 uM 8X5 C23 H25 N5 O2 c1ccc(cc1)....
226 5BUJ ic50 = 0.005 uM 4VB C16 H15 N5 O c1cnccc1c2....
227 5BUI ic50 = 0.089 uM 4V9 C17 H15 F N4 c1ccnc(c1)....
228 4QP7 ic50 = 5.9 uM 363 C9 H7 N5 c1c[nH]c2c....
229 3ERK ic50 = 18 uM SB4 C18 H19 F N6 c1cc(ccc1c....
230 5V60 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
231 1TVO Ki = 0.14 uM FRZ C18 H13 N7 c1ccc(cc1)....
232 5BVD ic50 = 0.16 nM 4VF C24 H26 Cl N5 O3 c1cc(cc(c1....
233 4ZZN ic50 = 0.26 uM CQ8 C18 H21 Cl N4 O2 CNC(=O)c1c....
234 3SA0 - NRA C13 H8 O6 c1c(cc2c(c....
235 4ERK ic50 = 27 uM OLO C15 H18 N6 O Cn1cnc2c1n....
236 5U6I - 81Y C19 H22 N4 O2 CC(C)Oc1cc....
237 5NHV ic50 = 0.0028 uM 8QB C16 H19 N5 O2 c1cnc(nc1c....
238 3I5Z Ki = 2 nM Z48 C24 H23 N5 O2 Cc1cnc(nc1....
239 4N0S - DHC C9 H8 O4 c1cc(c(cc1....
240 5NHP ic50 = 0.023 uM 8XK C19 H23 N7 O2 Cn1c(ccn1)....
241 3I60 Ki < 2 nM E86 C24 H22 Cl N5 O2 Cc1cnc(nc1....
242 4XP2 - TT4 C8 H9 N5 c1ccc(cc1)....
243 1PME Ki = 0.76 nM SB2 C21 H16 F N3 O S C[S@](=O)c....
244 5NHL ic50 < 0.0003 uM 8XB C20 H25 N7 O2 Cc1cnc(nc1....
245 5HD4 - 38Z C33 H33 N9 O2 c1cnc(nc1)....
246 5K4I ic50 = 3.1 nM 6QB C21 H18 Cl F N6 O2 Cn1c(ccn1)....
247 2F9G - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
248 2B9F - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
249 5AWM - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
250 4EYM - 0RX C21 H20 N4 O3 c1cc(ccc1N....
251 5EKO ic50 = 15785 nM N17 C22 H18 N4 O2 Cc1cn(cn1)....
252 4EYJ - N61 C20 H23 N5 O2 CC(C)(C)c1....
253 1CM8 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
254 4QTB Kd = 0.084 uM 38Z C33 H33 N9 O2 c1cnc(nc1)....
255 2ZOQ ic50 = 0.9 uM 5ID C11 H13 I N4 O4 c1c(c2c(nc....
256 3NPC - B96 C31 H37 N5 O3 Cc1ccc(cc1....
257 3E7O ic50 = 120 nM 35F C20 H14 N6 O2 c1cc(cc(c1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: N61; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 N61 1 1
2 BMU 0.621212 0.803279
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5EKO; Ligand: N17; Similar sites found: 271
This union binding pocket(no: 1) in the query (biounit: 5eko.bio1) has 24 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2QX0 PH2 0.0182 0.41087 1.25786
2 4LH7 1X8 0.004488 0.4479 1.54799
3 5HP8 PYR 0.0136 0.40643 1.6129
4 5VZ0 ADP 0.0122 0.40153 1.61725
5 2PUL ACP 0.0001488 0.48894 1.88679
6 1W2D ADP 0.002215 0.44923 1.88679
7 1J1R ADE 0.02953 0.4034 1.91571
8 4ZS4 ATP 0.001341 0.43691 1.9544
9 1IA9 ANP 0.004748 0.41289 2.14286
10 3PDT ADP 0.006416 0.41817 2.18182
11 4OUC 5ID 0.0004367 0.47269 2.52101
12 5GZ9 ANP 0.001002 0.43082 2.62295
13 5UC9 MYR 0.02013 0.41289 2.65487
14 5I35 ANP 0.002063 0.43683 2.69542
15 1TZD ADP 0.01147 0.41657 2.90909
16 2PYW ADP 0.0003768 0.45657 2.96496
17 5FPN KYD 0.001174 0.44874 3.2345
18 5MW8 ATP 0.001192 0.42772 3.2345
19 2AIQ BEN 0.01648 0.41489 3.4632
20 5XNA SHV 0.0353 0.40433 3.62319
21 3VOT ADP 0.00274 0.4447 3.77358
22 3X01 AMP 0.004321 0.44743 4.04313
23 4MRP GSH 0.007575 0.43711 4.04313
24 3I0O ADP 0.001214 0.46202 4.12979
25 3I0O SMI 0.01513 0.42009 4.12979
26 2YRX AMP 0.02978 0.40261 4.31267
27 1CBK ROI 0.01748 0.41651 5
28 5W2I I3P 0.003158 0.40483 5.05837
29 5W2I ADP 0.003158 0.40483 5.05837
30 4OCV ANP 0.004189 0.41527 5.12129
31 3CM2 X23 0.02015 0.41163 5.38462
32 4U98 ACP 0.0052 0.41848 5.39084
33 5OCA 9QZ 0.01312 0.43043 5.55556
34 4GYI ADP 0.0008144 0.46513 5.66038
35 3TII ANP 0.01742 0.40522 6.05263
36 4R78 AMP 0.0119 0.41766 6.14887
37 1ZTH ADP 0.0001886 0.50161 6.20155
38 3RE4 TO1 0.0002708 0.49392 6.20155
39 1ZP9 ATP 0.0003912 0.47492 6.20155
40 4O1P ANP 0.00005449 0.4565 6.73854
41 4CS9 AMP 0.01908 0.40388 6.87831
42 2IF8 ADP 0.004875 0.44227 6.88705
43 4OAV ACP 0.00003854 0.51571 7.00809
44 4AZT LY2 0.009677 0.41781 7.27763
45 2YFB SIN 0.01846 0.40321 7.36434
46 3KMW ATP 0.003727 0.4251 7.75194
47 4RDL FUC GAL NDG FUC 0.02444 0.40763 7.79221
48 4P7U 1PS 0.006518 0.44617 8.03571
49 3HAV ATP 0.0006083 0.49212 8.3612
50 4Z7X 3CX 0.02075 0.41063 8.40336
51 2UYN 2KT 0.02378 0.40247 9.30233
52 3Q60 ATP 0.0001911 0.48399 9.43396
53 4LRJ ANP 0.0003844 0.47014 9.46746
54 4WW7 AMP 0.00104 0.43384 9.62567
55 4O4Z N2O 0.02025 0.40813 9.74026
56 2PIE GLU LEU LYS TPO GLU ARG TYR 0.01366 0.41916 10.1449
57 3UDZ ADP 0.0008023 0.41831 10.5121
58 1BO4 COA 0.01861 0.40381 10.7143
59 5C03 AGS 0.003072 0.42496 10.8187
60 4WOV 3SM 0.01843 0.40402 11.6719
61 5CKW ANP 0.002786 0.44435 11.8598
62 4B1L FRU 0.01038 0.41992 15.1515
63 5F90 GLA GAL 0.02427 0.40809 15.3846
64 4FL3 ANP 0.0004104 0.45078 16.1725
65 4CYI ATP 0.0007658 0.44339 16.7116
66 3BU5 ATP 0.00001698 0.47423 16.9935
67 3VHE 42Q 0.000001949 0.49638 17.2702
68 5KEW 6SB 0.002538 0.46089 18.75
69 4XH0 ADP 0.000001162 0.63735 18.8679
70 1HFE CYS 0.01586 0.4222 19.5122
71 3LQV ADE 0.01242 0.4304 23.0769
72 5VC5 96M 0.0007565 0.41204 23.5294
73 2PZI AXX 0.0001576 0.49921 23.7197
74 4Q5H ANP 0.003767 0.42099 25
75 5T8O 76Z 0.0001276 0.4767 26.0745
76 4L9I 8PR 0.001069 0.44988 26.1905
77 4KBA 1QM 0.0003175 0.42696 26.284
78 5W4W 9WG 0.0002325 0.41426 26.284
79 3C1X CKK 0.00000002216 0.6297 26.4151
80 5DMZ ADP 0.001191 0.44334 26.5753
81 3V8S 0HD 0.00003849 0.51573 26.6846
82 4Y93 746 0.000511 0.42914 26.9542
83 3TXO 07U 0.000003865 0.48128 27.1955
84 3PVW QRX 0.00001999 0.47756 27.4933
85 5UKL SIX 0.00144 0.43114 27.4933
86 5KO1 6UY 0.00002478 0.52445 27.5618
87 5VCV 1N1 0.00005628 0.47427 27.6527
88 4WNK 453 0.0001754 0.42471 27.7628
89 4BTK DTQ 0.0001325 0.44185 27.8932
90 4Y8D 49J 0.000005303 0.54828 27.9412
91 3H9R TAK 0.000005904 0.58364 28.1818
92 4G17 0VN 0.0003538 0.41608 28.1818
93 3UIM ANP 0.00008904 0.49361 28.2209
94 4E93 GUI 0.0002187 0.41052 28.3019
95 4U44 3D9 0.00002335 0.47284 28.6145
96 4OTH DRN 0.0009502 0.43549 29.0323
97 4X7Q 3YR 0.0001287 0.48648 29.1667
98 5N87 N66 0.0001824 0.40113 29.393
99 5KMJ 6UF 0.0002928 0.44589 29.4833
100 3LXN MI1 0.000373 0.45676 29.5597
101 4OH4 ANP 0.0007067 0.45345 29.7297
102 3SLS ANP 0.0003615 0.45309 29.9342
103 2OO8 RAJ 0.0000005413 0.57152 29.9685
104 5LPZ ADP 0.0001399 0.48486 30.1205
105 3DLS ADP 0.0005228 0.40867 30.1493
106 3M2W L8I 0.0000548 0.52112 30.4348
107 4YMJ 4EJ 0.00001127 0.58483 30.5921
108 5EOB 5QQ 0.0000002895 0.62554 30.721
109 1XJD STU 0.00004382 0.50183 30.7246
110 4NFN 2KC 0.0001189 0.49339 30.7443
111 5HES 032 0.0002189 0.45231 30.9446
112 4M69 ANP 0.0001779 0.47051 30.9904
113 5NKB 8ZT 0.00000004545 0.47864 31.0458
114 1JPA ANP 0.000002734 0.60651 31.0897
115 4BHN BH9 0.001814 0.42736 31.1377
116 5AX9 4KT 0.0001122 0.48913 31.1688
117 4Y0X ADP 0.0001558 0.49357 31.2
118 5UIU 8CG 0.0004084 0.45738 31.2694
119 1BYG STU 0.0001085 0.50092 31.295
120 5HVJ ANP 0.0001758 0.52158 31.4286
121 2X2M X2M 0.000024 0.50248 31.5287
122 4AT3 LTI 0.000000534 0.51375 31.7726
123 4GJ3 0XP 0.0001584 0.419 31.7881
124 4DC2 ADE 0.0000006348 0.44246 31.8059
125 4QMN DB8 0.00003555 0.42182 31.9355
126 1VJY 460 0.0001754 0.41291 32.0132
127 5M06 ADP 0.00002895 0.52769 32.2464
128 3NW7 LGV 0.000002083 0.57768 32.2476
129 3PP0 03Q 0.000277 0.43282 32.2485
130 2WQN ADP 0.00001207 0.55251 32.2581
131 4EWH T77 0.00006957 0.44898 32.3636
132 1U59 STU 0.0002174 0.47631 32.4042
133 1U5R ATP 0.00002193 0.52077 32.4713
134 3CY2 MB9 0.0001868 0.46081 32.4841
135 3TKI S25 0.0001521 0.50095 32.5077
136 2HY0 306 0.00003755 0.52897 32.6087
137 5HCY 60D 0.000002367 0.42226 32.6284
138 2Y6O 1N1 0.000003809 0.53599 32.646
139 4E1Z 0MX 0.003749 0.40725 32.646
140 4D2S DYK 0.0000467 0.52445 32.7465
141 5MJA 7O3 0.0000004406 0.61251 32.7869
142 5TO8 7FM 0.0000001761 0.48068 32.9787
143 4CLI 5P8 0.00000007783 0.63814 33.0275
144 1K3A ACP 0.00002942 0.53403 33.1104
145 3KRL KRL 0.0002915 0.45702 33.1343
146 3VRY B43 0.0001416 0.45074 33.1536
147 3GGF GVD 0.0001778 0.49091 33.2226
148 4U0I 0LI 0.000001351 0.49581 33.3333
149 4ITH RCM 0.0009062 0.43636 33.3333
150 5LPB ADP 0.00001366 0.5574 33.4459
151 3SXS PP2 0.00005422 0.4926 33.5821
152 4ASE AV9 0.000001057 0.5191 33.711
153 2R5T ANP 0.0002788 0.45782 33.7802
154 4YZN 4K5 0.0003703 0.4486 33.7979
155 4BKJ STI 0.000002041 0.52379 33.9683
156 2PVF ACP 0.0001532 0.48837 34.1317
157 1OPK P16 0.0000008488 0.50231 34.2318
158 1ZY5 ANP 0.0004075 0.46898 34.3234
159 4I6H 1C8 0.001099 0.44489 34.4156
160 3SRV S19 0.00007637 0.44629 34.657
161 2QLU ADE 0.000027 0.57447 34.7134
162 4P5Z Q7M 0.00000002012 0.50575 34.903
163 4F4P 0SB 0.000001736 0.59479 35.1648
164 5JKG 6LF 0.000003083 0.5598 35.3698
165 3PLS ANP 0.00003664 0.51671 35.5705
166 2ZV2 609 0.00003573 0.53697 35.906
167 4NW6 2NS 0.0002494 0.40763 35.9133
168 2A19 ANP 0.00009001 0.51733 35.9155
169 5CEO 50D 0.00006038 0.45274 36
170 5JFS 6K0 0.0000005158 0.59701 36.039
171 3GNI ATP 0.0005137 0.45081 36.1186
172 3AQV TAK 0.001335 0.40459 36.2319
173 2XVD AS6 0.00008713 0.44217 36.4238
174 4IDT T28 0.0008881 0.45354 36.5169
175 5FBN 5WF 0.0001701 0.40684 36.5314
176 4A4X JUP 0.0002068 0.4385 36.5591
177 2YAB AMP 0.000406 0.45959 36.5651
178 5JGA 6KC 0.00000131 0.48703 36.8254
179 4C2V YJA 0.0001722 0.4279 36.8421
180 3ORK AGS 0.000174 0.44769 36.9775
181 2Z7R STU 0.0004474 0.44921 37.0717
182 2OFV 242 0.0000147 0.43974 37.1841
183 3MVH WFE 0.0003987 0.41028 37.4269
184 4YZC STU 0.000008683 0.53863 37.4663
185 2H8H H8H 0.0002924 0.47056 37.4663
186 1Y57 MPZ 0.001536 0.42319 37.4663
187 5DBX ANP 0.000004464 0.57315 37.5
188 4C2W ANP 0.00002672 0.44318 37.6344
189 4AG8 AXI 0.000009091 0.44926 37.6582
190 3IGO ANP 0.000325 0.45503 37.7358
191 5UOX 8GY 0.002403 0.41859 38.0074
192 5EYK 5U5 0.0001767 0.43601 38.0435
193 5U6C 7YS 0.0001911 0.4647 38.0952
194 5LI1 ANP 0.00003845 0.4939 38.1356
195 5H2U 1N1 0.0001225 0.48743 38.2022
196 3ALN ANP 0.0004544 0.45309 38.2263
197 3HZT J60 0.00006099 0.52561 38.2749
198 3GQI ACP 0.00074 0.45256 38.3436
199 3C0G 3AM 0.000105 0.50764 38.4615
200 4K33 ACP 0.0002911 0.4659 38.4615
201 5DA3 58V 0.000009314 0.56555 38.4906
202 5LI9 ACP 0.000001767 0.56273 38.5714
203 4BFM ANP 0.00002987 0.50367 38.9222
204 4WNP 3RJ 0.0001205 0.50478 39.0244
205 5L8L ADP 0.0001866 0.50184 39.2982
206 5G1X ADP 0.0003405 0.47254 39.2982
207 2RIO ADP 0.0001181 0.49352 39.3531
208 5LXM ADP 0.001024 0.45071 39.576
209 2V7O DRN 0.00001764 0.43526 39.5833
210 4YLL 4E3 0.00002215 0.49887 39.8892
211 1Q8Y ADE 0.000005135 0.58668 39.8922
212 2WU6 DKI 0.00005905 0.48137 39.8922
213 1Q8Y ADP 0.0001521 0.47343 39.8922
214 5MY8 RXZ 0.00004815 0.4687 39.8922
215 2QCS ANP 0.0001275 0.47353 40
216 5UR1 YY9 0.0000001426 0.47246 40.1929
217 1RE8 BD2 0.0001614 0.49344 40.2857
218 3IDB ANP 0.0004294 0.44595 40.2857
219 3FHI ANP 0.0001975 0.43849 40.2857
220 3HMO STU 0.00006745 0.50462 40.3509
221 4WB6 ATP 0.0001409 0.44353 40.5714
222 3RI1 3RH 0.00005233 0.46122 40.5751
223 4CSV STI 0.000002373 0.53874 40.7273
224 4XV1 904 0.000004959 0.54413 40.7534
225 4Y85 499 0.006246 0.41484 40.9639
226 2HK5 1BM 0.000008121 0.50357 41.1111
227 5IH9 6BF 0.000006171 0.45277 41.194
228 5LVP ATP 0.0001595 0.49896 41.4791
229 4CRL C1I 0.00000005892 0.52325 41.5094
230 5LXC 7AA 0.00000574 0.4785 41.5094
231 4JDI ANP 0.00005599 0.492 41.6185
232 3E5A VX6 0.001913 0.4072 41.791
233 4G31 0WH 0.00001784 0.44479 42.1405
234 4XLI 1N1 0.000001317 0.5826 42.1642
235 2VZ6 FEF 0.0007186 0.46773 42.1725
236 5TA6 79D 0.001011 0.40759 42.1788
237 4TWP AXI 0.0000001065 0.46291 42.4354
238 3KN5 ANP 0.001214 0.40287 42.4615
239 4CQE CQE 0.00009841 0.47679 42.8058
240 3FHR P4O 0.001434 0.43564 42.8571
241 5DH3 5BS 0.002599 0.42067 42.8571
242 4I94 ANP 0.0001408 0.49003 43
243 4JR7 GNP 0.0002889 0.4708 43.3155
244 1PHK ATP 0.0001643 0.44384 43.6242
245 4FG8 ATP 0.0006123 0.44755 43.8095
246 2WEL K88 0.0000006613 0.46151 44.0367
247 4L3L 5FI 0.00008878 0.48548 44.4079
248 4F9C 0SX 0.0000424 0.51382 44.5983
249 4NST ADP 0.0000431 0.50768 45.0142
250 4USF 6UI 0.001227 0.42902 45.0658
251 4IJP 1EH 0.0001475 0.45374 45.5307
252 5EFQ ADP 0.00002069 0.5219 45.5331
253 3G5D 1N1 0.00000002446 0.43861 45.8042
254 3F7Z 34O 0.0002809 0.47134 46
255 2YAK OSV 0.00003392 0.44789 46.3158
256 3DAK ANP 0.00002831 0.52814 46.8966
257 3ZRM ZRM 0.00000951 0.53696 46.9003
258 4KS7 X4Z 0.000135 0.46661 46.9178
259 2F57 23D 0.00006585 0.51103 47.0032
260 2WEI VGG 0.00003682 0.52282 47.0383
261 5X8I SQZ 0.000005088 0.54909 47.1098
262 4NM5 ADP 0.0001152 0.46944 47.1698
263 2JLD AG1 0.0003152 0.41378 47.1698
264 5JZJ AN2 0.0001412 0.48998 47.8114
265 5DEY 59T 0.0000007665 0.41669 47.8114
266 2VN9 GVD 0.00001105 0.56997 48.1728
267 3GC0 AMP 0.0005468 0.4734 48.3283
268 5A6N U7E 0.00009466 0.45518 48.4099
269 2X4Z X4Z 0.0001541 0.40858 48.6486
270 3PE2 E1B 0.0005967 0.46812 49.5549
271 5HQ0 LZ9 0.0001894 0.46935 49.6689
Feedback