-->
Receptor
PDB id Resolution Class Description Source Keywords
4EQU 2 Å EC: 2.7.11.1 HUMAN STK-10 (LOK) KINASE DOMAIN IN DFG-OUT CONFORMATION WIT INHIBITOR DSA-7 HOMO SAPIENS SERINE/THREONINE KINASE TRANSFERASE TRANSFERASE-TRANSFERASINHIBITOR COMPLEX
Ref.: AFFINITY-BASED PROBES BASED ON TYPE II KINASE INHIB J.AM.CHEM.SOC. V. 134 19017 2012
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
1PE B:405;
Invalid;
none;
submit data
238.278 C10 H22 O6 C(COC...
CA A:402;
A:403;
B:402;
B:403;
B:404;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
submit data
40.078 Ca [Ca+2...
G6I A:401;
B:401;
Valid;
Valid;
none;
none;
submit data
571.552 C30 H24 F3 N7 O2 Cc1cc...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2J7T 2 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF HUMAN SERINE THREONINE KINASE-10 BOUND HOMO SAPIENS KINASE TRANSFERASE ATP-BINDING CELL CYCLE PROGRESSION PHOSPHORYLATION DISEASE MUTATION NUCLEOTIDE- BINDING LYMORIENTED KINASE (LOK) SERINE/THREONINE- PROTEIN KINASE SERINE/THREONINE KINASE (STK10A)
Ref.: ACTIVATION SEGMENT DIMERIZATION: A MECHANISM FOR KI AUTOPHOSPHORYLATION OF NON-CONSENSUS SITES. EMBO J. V. 27 704 2008
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 117 families.
1 4EQU - G6I C30 H24 F3 N7 O2 Cc1ccc(cc1....
2 2J7T - 274 C28 H30 Cl N5 O4 S Cc1c([nH]c....
70% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 91 families.
1 4EQU - G6I C30 H24 F3 N7 O2 Cc1ccc(cc1....
2 2J7T - 274 C28 H30 Cl N5 O4 S Cc1c([nH]c....
3 4USF - 6UI C19 H15 N3 O COc1ccc2cc....
4 2J51 - DKI C15 H13 F2 N7 O2 S2 c1cc(c(c(c....
5 2UV2 - GVD C22 H19 N7 c1ccc2c(c1....
6 2JFL - DKI C15 H13 F2 N7 O2 S2 c1cc(c(c(c....
50% Homology Family (199)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 60 families.
1 2YM8 ic50 = 0.013 uM YM8 C19 H19 Cl N6 O C[C@H](CN(....
2 5OPU ic50 = 0.1237 uM A3K C15 H12 N4 Cc1cccc(c1....
3 5OP4 ic50 = 0.4476 uM A0T C19 H21 F4 N5 O3 CCNc1c(cnc....
4 2CGW ic50 = 17.3 uM 3C3 C9 H15 N9 O2 CCCn1c(nc(....
5 3F9N ic50 = 1.3 uM 38M C29 H35 Cl N4 O2 S CCCC[C@@H]....
6 4JIK ic50 = 0.039 uM 1KO C18 H19 Cl N6 O c1cc(ccc1c....
7 4QYH ic50 = 0.0013 uM 3DX C22 H20 N6 CN1CCN(CC1....
8 2BRB Ki = 13.7 uM PFQ C20 H17 N3 O2 c1ccc(cc1)....
9 3PA3 ic50 = 1 nM C70 C18 H18 Cl N5 O S c1cc(ccc1c....
10 5OQ6 ic50 = 0.0828 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
11 6FCF ic50 = 0.006 uM D58 C20 H22 N4 O S C[C@@H]1[C....
12 2YER ic50 = 0.02 uM TQ1 C15 H12 N4 O2 c1cc([nH]c....
13 2E9O ic50 = 20 nM A58 C25 H27 N3 O2 CC1CCC(CC1....
14 5OPB ic50 = 0.0577 uM A1N C21 H25 N5 O2 C[C@@H]1CN....
15 2WMQ - ZYQ C9 H11 N3 O2 S CC(=O)Nc1n....
16 2BRO ic50 = 1.4 uM DF2 C21 H20 N4 O2 c1ccc(cc1)....
17 2QHN ic50 = 980 nM 582 C13 H13 N3 O CCN1c2cccc....
18 4RVM ic50 = 1 nM 3X7 C23 H21 N5 c1cc(ccc1C....
19 5DLS ic50 = 4.4 nM 5CV C31 H34 N6 O3 CC(C)(CN(C....
20 3TKI ic50 = 0.05 nM S25 C20 H23 N7 O2 S c1cnc(cc1N....
21 2YM5 ic50 = 0.43 uM YM5 C18 H21 N5 O2 c1cc(cc(c1....
22 4HYH ic50 = 1 nM 1AM C22 H22 N6 O3 S COc1ccc2c(....
23 5OPV ic50 = 0.1203 uM A3H C19 H16 N6 Cc1cccc(c1....
24 5OOT ic50 = 0.0681 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
25 1NVS Ki = 15 nM UCM C24 H15 N3 O3 c1ccc2c(c1....
26 2YDK ic50 = 0.007 uM YDK C17 H20 N4 O2 S c1ccc(cc1)....
27 3OT3 ic50 = 0.005 uM 22K C16 H20 Br N7 Cn1cc(cn1)....
28 2HXQ ic50 = 144 nM 373 C24 H26 N4 O c1ccc2c(c1....
29 2QHM ic50 = 660 nM 7CS C16 H19 N3 O2 CN1[C@H]2C....
30 2BRH ic50 = 22 uM DFW C20 H15 N3 O3 c1ccc(cc1)....
31 2R0U ic50 = 1 nM M54 C25 H22 N4 O2 c1cc(cc(c1....
32 1NVR Ki = 7.8 nM STU C28 H26 N4 O3 C[C@@]12[C....
33 3OT8 ic50 = 0.009 uM MI5 C19 H22 N8 S Cc1cc(sn1)....
34 2YM4 ic50 = 1.5 uM 4YM C21 H22 N6 O3 CCOC(=O)c1....
35 4HYI ic50 = 2 nM 1AO C21 H20 N6 O S c1ccc2c(c1....
36 4RVL ic50 = 41.7 nM 3XL C17 H10 N4 O c1ccc(c(c1....
37 5JQ5 Kd = 2341 nM I74 C22 H30 N6 O CC(C)c1cnn....
38 2C6O - 4SP C18 H22 N6 O3 S c1cc(ccc1N....
39 1V1K Ki = 35 uM 3FP C22 H23 F4 N5 O2 CN(C)C[C@H....
40 2VTJ ic50 = 1.9 uM LZ4 C10 H9 Cl N4 O2 S c1cc(ccc1N....
41 3EZV - EZV C25 H25 N7 CN1CCN(CC1....
42 3PXZ Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
43 1W0X - OLO C15 H18 N6 O Cn1cnc2c1n....
44 2XMY Ki = 0.11 nM CDK C18 H21 N5 O4 S2 CC1=C(SC(=....
45 2UZO ic50 = 18 uM C62 C14 H10 N2 O5 S2 c1cc(ccc1c....
46 1KE7 ic50 = 8.9 nM LS3 C20 H15 N3 O4 S c1cc2c(cc1....
47 1DM2 - HMD C11 H10 Br N5 O2 C1CNC(=O)C....
48 1DI8 ic50 = 1 uM DTQ C16 H15 N3 O3 COc1cc2c(c....
49 5JQ8 - I73 C22 H30 N6 O CC(C)c1cnn....
50 1GIJ - 2PU C19 H22 N6 O2 c1cc2c(c(c....
51 2R3P ic50 = 900 nM 3SC C19 H12 Cl2 N6 S c1cc(c(c(c....
52 1KE8 ic50 = 1000 nM LS4 C18 H14 N4 O3 S2 c1ccc2c(c1....
53 2C6I ic50 = 11 uM DT1 C18 H22 N6 O3 S c1cc(ccc1N....
54 1PXP Ki ~ 0.22 uM CK8 C17 H19 N5 S Cc1c(sc(n1....
55 2UZN ic50 = 0.03 uM C96 C15 H13 N3 O4 S2 [H]/N=C/1N....
56 2B55 ic50 = 96 nM D31 C24 H31 N5 O2 c1cc-2c(c(....
57 5K4J - 6QB C21 H18 Cl F N6 O2 Cn1c(ccn1)....
58 3PJ8 - 404 C19 H26 N6 O CC[C@H](CO....
59 3LFQ - A28 C17 H15 F2 N3 O CCCC(=O)Nc....
60 2W05 ic50 = 0.001 uM FRT C20 H26 N6 O3 S Cc1ncc(n1C....
61 2XNB Ki = 149 nM Y8L C19 H22 N6 O S CC1=C(SC(=....
62 1HCK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
63 5IEX - 6AF C17 H21 Br N4 O3 S C[C@H]([C@....
64 2R3H ic50 = 20000 nM SCE C13 H13 N5 Cc1cnc2n1c....
65 4O0X Ki = 0.068 uM 2OQ C19 H20 N6 O Cc1nc2ccc(....
66 4O0Y Ki = 0.06 uM 2OO C17 H19 N7 O CCNc1nc2cc....
67 5LI9 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
68 3A8W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
69 2F2U - M77 C14 H17 N3 O2 S c1cc2cnccc....
70 3OWL ic50 = 0.67 uM 19E C16 H11 Cl N2 O Cc1cnc(c2c....
71 5OYF - B4Q C25 H27 N3 CCc1ccccc1....
72 5H8G ic50 < 0.003 uM 5Y4 C23 H29 N9 O CC(=O)Nc1c....
73 5OS7 - A8Q C16 H19 Cl N CC(C)c1ccc....
74 5OTZ Kd = 6.5 uM AUT C15 H15 Cl2 N CCc1ccccc1....
75 5OUM - AVK C18 H18 Cl N3 c1ccc(cc1)....
76 5B0X ic50 = 0.02 uM HCK C18 H14 N2 O4 S COc1ccc(cc....
77 5MO8 Kd = 1.64 uM C98 C26 H26 Cl N3 O4 c1ccc(cc1)....
78 3R1N - 05B C22 H21 N5 O3 c1cc2c(cc1....
79 3BWJ ic50 = 2.6 uM ARX C28 H47 N15 O7 [H]/N=C(N)....
80 3AGL Ki = 16 nM A03 C37 H63 N17 O9 [H]/N=C(N)....
81 1RE8 Ki = 0.3 nM BD2 C27 H26 N2 O6 c1ccc(c(c1....
82 1SZM ic50 = 6.35 uM BI4 C27 H26 N4 O2 C[N@]1CCC[....
83 1REJ Ki = 5 nM B1L C20 H22 N2 O5 c1cc(ccc1C....
84 2Z7Q - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
85 1MQ4 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
86 5EW9 Ki < 0.01 nM 5VC C22 H21 Cl F N3 O3 S c1cc(nc(c1....
87 5ORY ic50 = 407 uM AY4 C9 H6 F2 N2 O c1c[nH]nc1....
88 4CEG - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
89 5ORV Kd = 1297 uM A65 C6 H9 N O S3 CSc1c(c(sn....
90 5OS6 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
91 3DJ6 - AK6 C25 H24 N4 O3 S COc1ccc(cc....
92 5OSF - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
93 2WQE - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
94 6CPF - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
95 3FDN ic50 = 0.033 uM MMH C21 H22 N6 O3 Cc1c(c([nH....
96 3KXH - K66 C11 H9 Br4 N3 O2 CN(C)c1nc2....
97 4DGM ic50 = 1.2 uM AGI C15 H10 O5 c1cc(ccc1C....
98 3PVG - K68 C9 H4 Br4 N2 O2 c1nc2c(n1C....
99 1ZOG Ki = 0.07 uM K37 C8 H4 Br4 N2 S CSc1[nH]c2....
100 2PVJ Ki = 0.005 uM P44 C19 H21 N7 c1ccc(cc1)....
101 1P4F - DRG C12 H11 N3 c1ccc-2c(c....
102 4TXC Kd = 0.24 uM 38G C24 H27 N5 O3 CN(C)CCN[C....
103 2YAK ic50 = 2 nM OSV C27 H31 F N4 O3 Ru S4 CC(C)Oc1cc....
104 5AUY ic50 = 1.6 uM MRI C15 H10 O7 c1cc(c(cc1....
105 2HY0 ic50 = 0.65 nM 306 C26 H25 N5 O c1cc2c(cc1....
106 5LVO - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
107 4XX9 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
108 2XCK ic50 = 713 nM MH4 C29 H33 N9 O Cc1cc(ccn1....
109 3QD4 ic50 = 0.00000001 M 3Q6 C22 H30 N8 O2 C[C@@H]1C[....
110 3RCJ ic50 = 0.8 uM 3RC C16 H13 N5 c1ccc(cc1)....
111 2PE0 - 39Z C14 H12 N2 O2 CC(c1ccc[n....
112 4CT2 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
113 5ACK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
114 3HRC - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
115 5LVM - ADE C5 H5 N5 c1[nH]c2c(....
116 5MRD ic50 = 36.4 uM S26 C18 H13 Cl N2 O4 S2 CCOC(=O)C1....
117 3ION ic50 = 8 nM 8H1 C28 H27 N5 O3 COc1cc2c3c....
118 1UU7 ic50 = 14 uM BI2 C27 H26 N4 O2 C[N@@]1CCC....
119 3HRF Kd = 10.3 uM P47 C17 H15 Cl O2 c1ccc(cc1)....
120 3QCS ic50 = 0.00000001 M 3Q1 C15 H17 N7 O c1cc2c(cc1....
121 1H1W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
122 4AW1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
123 2PE2 - 464 C28 H30 N6 O3 c1cc(cc(c1....
124 3H9O ic50 = 70 nM 9BD C19 H19 N5 O3 COCCOc1cc2....
125 3QD3 ic50 = 0.00000001 M 3Q5 C22 H30 N8 O2 C[C@H]1CC[....
126 1OKY ic50 = 6.5 nM STU C28 H26 N4 O3 C[C@@]12[C....
127 3IOP ic50 = 17 nM 8I1 C28 H27 N5 O3 COc1cc2c3c....
128 2PE1 ic50 = 6 nM 517 C15 H14 N4 O2 CC(c1ccc[n....
129 3RWP Ki = 0.6 nM ABQ C24 H24 F N7 O2 CC(C)n1cc(....
130 3NAX - MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
131 3QCQ ic50 = 0.00000001 M 3Q0 C13 H15 N7 CCNc1cc(nc....
132 4A06 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
133 2R5T - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
134 2JDO ic50 = 0.23 uM I5S C20 H22 Cl N3 O3 S c1cc2cnccc....
135 1O6K - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
136 3E88 Ki = 2 nM G96 C24 H27 N7 O3 CCn1c2cc(n....
137 2UW9 - GVP C20 H20 Cl N3 c1cc(ccc1c....
138 2JDR ic50 = 0.5 nM L20 C24 H23 N5 O Cc1c2cc(cc....
139 3D0E ic50 = 13 nM G93 C21 H27 N7 O3 CCn1c2c(cn....
140 4QMX ic50 = 11 uM H8H C27 H32 Cl N5 O5 CN1CCN(CC1....
141 4QMT ic50 = 0.01 uM H1N C29 H32 N4 O3 S CCS(=O)(=O....
142 4QMM ic50 = 0.46 uM 35R C19 H23 N7 O2 c1cc2c(cc1....
143 4QMU ic50 = 1.3 uM SKE C15 H12 F2 N6 O3 S c1cc(c(c(c....
144 4W8E - 3JB C20 H17 N7 O2 Cc1nc(no1)....
145 4QMZ ic50 = 0.21 uM B49 C22 H27 F N4 O2 CCN(CC)CCN....
146 3UBD Kd = 2.9 uM SL0 C25 H24 O12 CC1C(C(C(C....
147 4GUE Kd = 5.8 uM QCT C21 H20 O11 C[C@H]1[C@....
148 3G51 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
149 4NUS ic50 = 0.005 uM 2NK C22 H21 F2 N3 O CN1CCN(CC1....
150 4NW6 ic50 = 0.004 uM 2NS C23 H20 N4 O4 COc1cc(cc(....
151 4NW5 ic50 = 0.02 uM 2NR C23 H21 F N2 O5 COc1cccc(c....
152 1U5R - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
153 2W7X ic50 = 138 nM D1A C18 H17 N7 O3 [H]/N=C(N)....
154 4A9U - A9U C27 H28 N4 O2 c1ccc(cc1)....
155 2YCF ic50 = 0.7 nM YCF C19 H24 N10 O3 [H]/N=C(N/....
156 4BDI ic50 = 227.7 uM HAU C14 H19 N3 O2 Cc1ccc(nc1....
157 2YCR ic50 = 69.6 nM HCW C23 H28 N10 O C/C(=NNC1=....
158 2WTJ ic50 = 0.7 uM WTJ C16 H20 N4 O3 S CN(C)CCNC(....
159 4BDB ic50 = 85.6 uM ODO C8 H9 N O3 C/C(=NO)/c....
160 2YIT ic50 = 0.29 nM YIT C21 H24 N6 O2 CCC/C(=NNC....
161 2W0J ic50 = 240 nM ZAT C19 H24 N10 O [H]/N=C(N)....
162 6CCY ic50 = 0.003 uM EX4 C29 H33 F4 N7 O C[C@@H]1CC....
163 3QKK - SMH C28 H38 N2 O7 S CCOCCN(C[C....
164 4EKL ic50 = 5 nM 0RF C24 H32 Cl N5 O2 C[C@@H]1C[....
165 3CQW ic50 = 42 nM CQW C12 H11 Cl N6 c1c(c2c([n....
166 4GV1 ic50 = 3 nM 0XZ C21 H25 Cl N6 O2 c1cc(ccc1[....
167 3MVH ic50 = 0.5 nM WFE C20 H22 F2 N6 O CCc1c[nH]c....
168 3MV5 ic50 = 180 nM XFE C11 H15 N5 Cc1c[nH]c2....
169 3QKL - SMR C29 H40 N4 O5 S CCOCC[N@@]....
170 5DH3 ic50 = 38.1 nM 5BS C17 H16 N6 O3 S2 CN1c2ccsc2....
171 5OTF - AQ5 C20 H24 N6 c1cnc2c(c1....
172 3TKU ic50 = 1.92 uM M77 C14 H17 N3 O2 S c1cc2cnccc....
173 3V8S ic50 = 0.65 uM 0HD C16 H16 N4 O c1ccc(cc1)....
174 4OTH ic50 = 9 nM DRN C25 H23 N5 O2 S [H]/N=C(/N....
175 5OOI - 9YE C23 H25 N O3 CC(C)n1c2c....
176 6CQF ic50 = 0.0045 uM F97 C21 H26 F2 N8 CC(C)n1c2c....
177 3A62 - STU C28 H26 N4 O3 C[C@@]12[C....
178 3WF9 ic50 = 567 nM FS7 C24 H25 N3 O5 S C[C@H]1CCc....
179 3WF8 ic50 = 232 nM F76 C23 H23 N3 O5 S c1ccc2c(c1....
180 4L3L - 5FI C19 H21 F3 N6 CCc1cncnc1....
181 3WE4 ic50 = 15 nM 5FI C19 H21 F3 N6 CCc1cncnc1....
182 3WF5 ic50 = 81 nM FZ8 C17 H17 N7 c1ccc2c(c1....
183 3FY0 ic50 = 1090 nM DW1 C23 H13 N3 O4 Ru C1=CC(C=C1....
184 4EQU - G6I C30 H24 F3 N7 O2 Cc1ccc(cc1....
185 4OBQ ic50 = 0.065 uM 2QT C20 H20 F N5 O c1cc2c(cc1....
186 4U43 Kd = 48 uM 3D8 C11 H9 N5 c1cc(cnc1)....
187 4OBP ic50 = 0.017 uM 2QU C12 H8 F N5 c1cc(nc2c1....
188 6C0T ic50 = 43 nM EE4 C30 H30 F N5 O5 CCCOc1ccc(....
189 6BXI - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
190 3DV3 - MEK C18 H18 F3 I N2 O5 c1cc(c(cc1....
191 3EQD - AGS C10 H16 N5 O12 P3 S c1nc(c2c(n....
192 5F9E ic50 = 0.46 nM 5VS C23 H21 N5 O2 CC1(NC(=O)....
193 1XJD Ki = 0.33 nM STU C28 H26 N4 O3 C[C@@]12[C....
194 5DBX - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
195 3TXO ic50 = 9 nM 07U C17 H19 N5 CC(C)(CNc1....
196 4USF - 6UI C19 H15 N3 O COc1ccc2cc....
197 2J51 - DKI C15 H13 F2 N7 O2 S2 c1cc(c(c(c....
198 1V0P ic50 = 0.13 uM PVB C20 H25 Cl N6 O3 CC(C)[C@H]....
199 1V0O ic50 = 5.5 uM INR C16 H10 N2 O5 S c1ccc2c(c1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: G6I; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 G6I 1 1
2 G6H 0.814815 0.925926
3 G6G 0.634146 0.69697
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2J7T; Ligand: 274; Similar sites found with APoc: 457
This union binding pocket(no: 1) in the query (biounit: 2j7t.bio1) has 30 residues
No: Leader PDB Ligand Sequence Similarity
1 4WG0 CHD None
2 2D6M LBT None
3 5KK4 44E None
4 4IV9 TSR 0.993378
5 3M3E GAL A2G NPO 1.24224
6 2VQD AP2 1.3245
7 1RTF BEN 1.5873
8 3B6O TMP 1.61943
9 1F9V ADP 1.65563
10 3HP9 CF1 1.65563
11 4YZ5 SLT 1.65563
12 3VPC ADP 1.77305
13 4CC6 L5Y 1.98676
14 1VRP IOM 1.98676
15 2IO8 ADP 1.98676
16 4MOB ADP 1.98676
17 1VKF CIT 2.12766
18 1A78 TDG 2.23881
19 4DFU QUE 2.31788
20 5FPN KYD 2.31788
21 5MW8 ATP 2.31788
22 5W3Y ACO 2.31788
23 1MJT ITU 2.31788
24 5W1E PHB 2.31788
25 5XLS URA 2.31788
26 3WV6 GAL GLC 2.36486
27 3WV6 GAL BGC 2.36486
28 3ZVS MLI 2.5
29 4HBM 0Y7 2.5
30 4RF7 ARG 2.64901
31 4GLW 0XT 2.64901
32 5L2R MLA 2.64901
33 3HQ9 OXL 2.64901
34 1RYD GLC 2.64901
35 1RJW ETF 2.64901
36 4KYS VIB 2.64901
37 1YFS ALA 2.64901
38 1EHI ADP 2.64901
39 5WS9 OXL 2.64901
40 3FSY SCA 2.64901
41 4ZGP ADP 2.73038
42 6EWZ APC 2.95359
43 3UDZ ADP 2.98013
44 4OCV ANP 2.98013
45 6EOM ALA LYS 2.98013
46 3E7S AT2 2.98013
47 3TY5 ADP 2.98013
48 3TY5 ATP 2.98013
49 6FL8 ADP 2.98013
50 6FL8 TIY 2.98013
51 4RW3 TDA 2.98013
52 4RW3 PLM 2.98013
53 5AHS SIN 2.98013
54 2CIX CEJ 3.01003
55 3CM2 X23 3.07692
56 3DGY 2GP 3.09278
57 2AK3 AMP 3.09735
58 5ZCT ANP 3.31126
59 5VZ0 ADP 3.31126
60 5I35 ANP 3.31126
61 3WVR AMP 3.31126
62 2Z9I GLY ALA THR VAL 3.31126
63 6MVU K4V 3.31126
64 3UG4 AHR 3.31126
65 6FXR AKG 3.31126
66 3S6X SIA GAL BGC 3.31126
67 3VSV XYS 3.31126
68 5EHS 5OY 3.35821
69 5EHS 2JJ 3.35821
70 5NFB 8VT 3.40909
71 3WUR O4B 3.50877
72 2YLN CYS 3.53357
73 1JGS SAL 3.62319
74 5DZT AMP 3.64238
75 4UWH JXM 3.64238
76 5DXT 5H5 3.64238
77 5FI4 5XV 3.64238
78 5IM3 DTP 3.64238
79 5OLK DTP 3.64238
80 2HFK E4H 3.64238
81 3EW2 BTN 3.7037
82 1P6O HPY 3.72671
83 4DM8 REA 3.74532
84 6CB2 OLC 3.75427
85 3KMR EQN 3.7594
86 2IDO TMP 3.76344
87 4YDU ADP 3.79747
88 5OF1 SAL 3.80952
89 5HWV MBN 3.84615
90 4G86 BNT 3.87324
91 1IA9 ANP 3.92857
92 3F8C HT1 3.96825
93 5CGE 51F 3.97112
94 1I7L ATP 3.97351
95 4U98 ACP 3.97351
96 2YRX AMP 3.97351
97 5YJS SAL 3.97351
98 4ZX2 4TE 3.97351
99 5MRH Q9Z 3.97351
100 4LBP 1WG 4
101 3T4L ZEA 4.07407
102 2C3H GLC GLC 4.08163
103 5NM7 GLY 4.13534
104 3NJQ NJQ 4.14508
105 5HCN DAO 4.21456
106 3M94 M7M 4.2328
107 4CS9 AMP 4.2328
108 5OES ADP 4.30464
109 2PUL ACP 4.30464
110 2PYW ADP 4.30464
111 4XNV BUR 4.30464
112 1V6A TRE 4.30464
113 1DTL BEP 4.34783
114 6GNO XDI 4.44444
115 5XJ7 87O 4.47761
116 5C1P ADP 4.57516
117 5DYO FLU 4.58716
118 1XX4 BAM 4.5977
119 5HV7 RBL 4.63576
120 3KP6 SAL 4.63576
121 6EZ6 C5Z 4.63576
122 5AE9 OKO 4.63576
123 1CKN GTP 4.63576
124 2PNC CLU 4.63576
125 4D4U FUC NDG GAL FUC 4.63576
126 1CKM GTP 4.63576
127 4D52 GXL 4.63576
128 4AF5 CIT 4.73684
129 4XZ3 ACP 4.78261
130 4XYM A12 4.78261
131 4EXO PYR 4.79452
132 1Y7P RIP 4.96689
133 3I0O ADP 4.96689
134 3B99 U51 4.96689
135 6EKZ SNP 4.96689
136 5DXG EST 4.98084
137 5DX3 EST 4.98084
138 5WGD EST 4.98084
139 5WGQ EST 4.98084
140 5DXE EST 4.98084
141 3SAO DBH 5
142 2QX0 PH2 5.03145
143 5NLD LBT 5.03597
144 2G30 ALA ALA PHE 5.03876
145 5HYR EST 5.03876
146 2QA8 GEN 5.03876
147 2QZO KN1 5.03876
148 6A63 LAT 5.07246
149 4MGA 27L 5.09804
150 4MG9 27K 5.09804
151 4TUZ 36J 5.09804
152 4MG7 27H 5.09804
153 4MG8 27J 5.09804
154 3THR C2F 5.11945
155 4TV1 36M 5.17928
156 3UUD EST 5.17928
157 3X01 AMP 5.29801
158 1AUX AGS 5.29801
159 2Z3U CRR 5.29801
160 1PK8 ATP 5.29801
161 1XK5 TPG 5.39216
162 4UMJ BFQ 5.40541
163 6BMN PAP 5.42373
164 4XMF HSM 5.43478
165 5TVI MYR 5.43478
166 1S9D AFB 5.4878
167 3CBC DBS 5.55556
168 5VX9 FUC GAL NAG GAL BGC 5.59006
169 1YYE 196 5.59701
170 2CFM AMP 5.62914
171 5VLQ ANP 5.62914
172 3COW 52H 5.62914
173 4O4Z N2O 5.84416
174 1UH4 GLC GLC GLC GLC GLC 5.96026
175 4P25 FUC GAL NAG FUC 5.96026
176 3I8T LBT 6.09756
177 1RZX ACE VAL LYS GLU SER LEU VAL 6.12245
178 4INI AMP 6.15385
179 1U3R 338 6.22407
180 4J26 EST 6.25
181 4J24 EST 6.25
182 5TP0 BRN 6.25
183 4P7U 1PS 6.25
184 4R78 AMP 6.29139
185 3TII ANP 6.29139
186 4M26 AKG 6.29139
187 2VDF OCT 6.32411
188 3ZJX BOG 6.57439
189 4GYI ADP 6.62252
190 1U6R IOM 6.62252
191 1T36 ADP 6.62252
192 4B0T ADP 6.62252
193 5C79 PBU 6.66667
194 5YW5 ADE 6.70391
195 1SLT NDG GAL 6.71642
196 3GQK ATP 6.74847
197 3VPD ANP 6.76157
198 1VMK GUN 6.85921
199 1LSH PLD 6.95364
200 3JU6 ANP 6.95364
201 5OCA 9QZ 6.95364
202 1R6N 434 7.109
203 4NPL AKG 7.2
204 1S68 AMP 7.22892
205 1NC4 DOF 7.23982
206 4K55 H6P 7.25806
207 2QK4 ATP 7.28477
208 1GSA ADP 7.28477
209 6C1S EFV 7.28477
210 2YW2 ATP 7.28477
211 3SJK LYS PRO VAL LEU ARG THR ALA 7.36842
212 2IUW AKG 7.56302
213 4O1P ANP 7.61589
214 1M2Z BOG 7.7821
215 3RV5 DXC 7.86517
216 3VOT ADP 8.27815
217 2VPQ ANP 8.27815
218 4MRP GSH 8.27815
219 5UC9 MYR 8.40708
220 3NB0 G6P 8.60927
221 5W7B MYR 8.60927
222 4OUE IPT 8.60927
223 1ULE GLA GAL NAG 8.66667
224 1MID LAP 8.79121
225 3ORQ ADP 9.27152
226 5KJW 53C 9.27152
227 3VMG 9CA 9.56522
228 2IF8 ADP 9.60265
229 4RYV ZEA 9.67742
230 5NC1 NAG 9.70464
231 5CXI 5TW 9.85222
232 5YK1 ANP 9.93377
233 5IUY BOG 10.1545
234 1TZD ADP 10.1818
235 1L0I PSR 10.2564
236 1W2D ADP 10.566
237 6F5U CQN 10.596
238 5EQY 5RA 10.596
239 4CYI ATP 10.9272
240 3WUC GLC GAL 10.9489
241 2HPL ASP ASP LEU TYR GLY 11
242 2ZL7 FUC GAL NGA 11.5254
243 5OSW DIU 11.5894
244 4AZW ATP 11.5894
245 1T0S BML 11.6279
246 1M0W ANP 11.9205
247 4Z28 BTN 12.6866
248 1A0J BEN 13.0045
249 1ZTH ADP 13.1783
250 6ACS CIT 13.1783
251 1ZP9 ATP 13.1783
252 4OGQ 7PH 13.4884
253 4RDL FUC GAL NDG FUC 13.9073
254 4WOE ADP 13.9073
255 4LI4 AMP 13.9706
256 4URX FK1 14.0541
257 1MT1 AG2 14.1593
258 2GTF P1R 14.4444
259 5N0L ILE 14.4654
260 1ZEI CRS 15.0943
261 5K2M ADP 15.0943
262 4WW7 AMP 15.3257
263 3LQV ADE 15.3846
264 2D5X L35 15.7534
265 5LX9 OLB 15.8451
266 4OAV ACP 15.894
267 5N26 CPT 15.9341
268 3VPB ADP 16.0714
269 5LXT GTP 16.0839
270 2BKK ADP 16.568
271 5Z84 CHD 17.3913
272 2XOC ADP 18.0077
273 5CKW ANP 18.8742
274 3HAV ATP 19.0635
275 5KEW 6SB 20.2128
276 6GMN F4E 21.1538
277 4XH0 ADP 22.8477
278 2CSN CKI 22.8956
279 4WOV 3SM 23.1788
280 5C03 AGS 23.1788
281 5OKT 9XK 24.8344
282 4UX9 ANP 25.1656
283 4IZY 1J2 25.1656
284 4KBA 1QM 26.1589
285 3VHE 42Q 26.4901
286 4E93 GUI 29.8013
287 5AWM ANP 30.1325
288 5JFS 6K0 30.4636
289 3E7O 35F 30.7947
290 4YMJ 4EJ 30.7947
291 4BTK DTQ 30.7947
292 5QIN J2V 31.1258
293 5X8I SQZ 31.1258
294 6G33 5ID 31.1258
295 3UIM ANP 31.1258
296 2QLU ADE 31.2102
297 5GZ9 ANP 31.457
298 5HCY 60D 32.1192
299 1VJY 460 32.1192
300 4IX4 ADP 32.1192
301 6FYV 3NG 32.4503
302 6A1G 9OL 32.4503
303 3PP0 03Q 32.7815
304 4AT3 LTI 33.1104
305 4CRL C1I 33.1126
306 6FYL 3NG 33.1126
307 2B9H ADP 33.1126
308 2B9F ADP 33.1126
309 2B9I ADP 33.1126
310 2B9J ADP 33.1126
311 3ZRM ZRM 33.4437
312 3F7Z 34O 33.4437
313 1O9U ADZ 33.7748
314 2XVD AS6 33.7748
315 4NM5 ADP 33.7748
316 6GWR FEW 33.7748
317 2JLD AG1 33.7748
318 5LPB ADP 33.7838
319 4YZC STU 34.106
320 5U6C 7YS 34.106
321 1U59 STU 34.1463
322 3VRY B43 34.7682
323 3BZ3 YAM 34.7826
324 4GJ3 0XP 35.0993
325 3LXN MI1 35.0993
326 4Y93 746 35.4305
327 5NKB 8ZT 36.4238
328 5ZTN CUR 36.4238
329 4E1Z 0MX 36.4261
330 5KO1 6UY 36.7491
331 5USZ SKE 37.3702
332 3TTI KBI 37.4172
333 4WHZ 3NL 37.4172
334 3PTG 932 37.4172
335 1OUK 084 37.7483
336 5HES 032 37.7483
337 4LOO SB4 37.7483
338 4FL3 ANP 38.0795
339 3PLS ANP 38.255
340 1JPA ANP 38.4106
341 5Y86 HRM 38.4106
342 2Y6O 1N1 38.488
343 2HK5 1BM 38.8889
344 2F2U M77 39.0728
345 4CLI 5P8 39.0728
346 5EOB 5QQ 39.0728
347 3C1X CKK 39.0728
348 6GU6 1QK 39.0728
349 5HQ0 LZ9 39.0728
350 4IDT T28 39.404
351 5BVE 4VG 39.404
352 5FBN 5WF 39.4834
353 4P5Z Q7M 39.7351
354 4H3P ANP 39.7351
355 4H3Q ANP 39.7351
356 5T8O 76Z 39.7351
357 4QTB 38Z 40.0662
358 4U0I 0LI 40.3974
359 6GQM F8H 40.3974
360 2H8H H8H 40.3974
361 3KMW ATP 40.5904
362 1Y57 MPZ 40.7285
363 5WNL STU 41.0596
364 6ES0 BW8 41.0596
365 4FF8 14S 41.3907
366 4WNK 453 41.3907
367 2OFV 242 41.5162
368 3LXK MI1 41.7219
369 3H9R TAK 41.7219
370 4Y85 499 41.7219
371 5TO8 7FM 41.844
372 6GIN IR2 41.8605
373 2OO8 RAJ 42.053
374 3NW7 LGV 42.053
375 2X2M X2M 42.053
376 6C0T EE4 42.053
377 5MJA 7O3 42.2951
378 5WO4 B7V 42.3841
379 3GC0 AMP 42.3841
380 1BYG STU 42.446
381 1K3A ACP 42.4749
382 1OPK P16 42.7152
383 4BHN BH9 42.7152
384 3BU5 ATP 42.7152
385 3EKK GS2 42.7152
386 5EKO N17 42.7152
387 1XJD STU 42.7152
388 2WU6 DKI 42.7152
389 3FHI ANP 42.7152
390 4OTH DRN 42.7152
391 2QCS ANP 42.7152
392 4AG8 AXI 43.0464
393 4ASE AV9 43.0464
394 5TA6 79D 43.0464
395 3IDB ANP 43.0464
396 3FC2 IBI 43.0464
397 1RE8 BD2 43.0464
398 4I6H 1C8 43.0464
399 5LPZ ADP 43.0464
400 2GU8 796 43.0464
401 1IR3 ANP 43.0464
402 1V0O INR 43.0556
403 3SRV S19 43.3213
404 3G5D 1N1 43.3566
405 3PVW QRX 43.3775
406 5UKL SIX 43.3775
407 5JGA 6KC 43.7086
408 4UXL 5P8 43.7086
409 4WB6 ATP 43.7086
410 4WB7 ATP 43.7086
411 2WEL K88 43.7086
412 6E2O S0L 43.7288
413 4F4P 0SB 43.956
414 4EWH T77 44
415 3KRL KRL 44.0397
416 2A19 ANP 44.3662
417 3RI1 3RH 44.3709
418 4PNI KQQ 44.3709
419 5N87 N66 44.3709
420 4L9I 8PR 44.3709
421 3SXS PP2 44.403
422 6CZ3 FLJ 44.697
423 1CM8 ANP 44.702
424 4K33 ACP 44.702
425 3HMO STU 44.702
426 6C7Y ADP 44.7552
427 5JKG 6LF 45.0331
428 3TXO 07U 45.0331
429 5LI1 ANP 45.0331
430 5LI9 ACP 45.0331
431 1ZY5 ANP 45.3642
432 4DC2 ADE 45.3642
433 4TWP AXI 45.3875
434 5CEO 50D 45.6667
435 3GQI ACP 45.6954
436 3O0G 3O0 45.8904
437 1UNH IXM 45.8904
438 5VC5 96M 46.0208
439 5UR1 YY9 46.0265
440 4CSV STI 46.5455
441 4CFU 2WC 46.6887
442 6GUE FB8 46.6887
443 2BPM 529 46.6887
444 5H2U 1N1 46.8165
445 4BCM T7Z 46.8439
446 4BCQ TJF 46.8439
447 4RFM 3P6 46.9925
448 4BCN T9N 47
449 4NST ADP 47.0199
450 2XMY CDK 47.3154
451 3GC8 B45 47.351
452 3GNI ATP 47.351
453 5EFQ ADP 47.351
454 5LMK 6ZK 47.4747
455 2PVF ACP 47.6821
456 5MY8 RXZ 48.0132
457 2F57 23D 49.6689
Pocket No.: 2; Query (leader) PDB : 2J7T; Ligand: 274; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2j7t.bio1) has 30 residues
No: Leader PDB Ligand Sequence Similarity
APoc FAQ
Feedback