Receptor
PDB id Resolution Class Description Source Keywords
4D2S 2.5 Å EC: 2.7.12.1 HUMAN TTK IN COMPLEX WITH A DYRK1B INHIBITOR HOMO SAPIENS TRANSFERASE ONCOLOGY
Ref.: DISCOVERY AND OPTIMIZATION OF A NOVEL SERIES OF DYR KINASE INHIBITORS TO EXPLORE A MEK RESISTANCE HYPOT J.MED.CHEM. V. 58 2834 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
DYK A:1794;
Valid;
none;
ic50 = 0.02 uM
430.502 C24 H26 N6 O2 CN1CC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4D2S 2.5 Å EC: 2.7.12.1 HUMAN TTK IN COMPLEX WITH A DYRK1B INHIBITOR HOMO SAPIENS TRANSFERASE ONCOLOGY
Ref.: DISCOVERY AND OPTIMIZATION OF A NOVEL SERIES OF DYR KINASE INHIBITORS TO EXPLORE A MEK RESISTANCE HYPOT J.MED.CHEM. V. 58 2834 2015
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 4D2S ic50 = 0.02 uM DYK C24 H26 N6 O2 CN1CCC(CC1....
70% Homology Family (19)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 3HMP ic50 = 38.41 uM CX4 C12 H12 Cl N3 c1cc2c(cc1....
2 3HMO ic50 = 0.102 uM STU C28 H26 N4 O3 C[C@@]12[C....
3 5N9S ic50 = 2.4 nM 8QW C29 H26 F N5 O4 S C[C@H](c1c....
4 5N87 ic50 = 0.9 nM N66 C33 H39 N7 O2 CCc1cccc(c....
5 5AP0 - AU5 C24 H32 N6 O3 CN1CCC(CC1....
6 5MRB Kd = 471 nM C5N C33 H40 N8 O2 CCc1cccc(c....
7 4C4J - X21 C26 H26 Cl N7 O2 CC(C)(C)OC....
8 5N93 Ki = 7.7 nM 8QE C17 H20 N6 O CC(C)(C)Nc....
9 4C4F - 7CE C17 H14 N4 O2 COc1ccccc1....
10 5AP6 - PWU C26 H27 N7 O2 Cc1ncc(n1C....
11 5EI6 ic50 = 0.099 uM 5OQ C21 H20 N4 O2 Cn1cc(cn1)....
12 5AP7 - SVE C35 H39 F3 N8 O3 CCc1cccc(c....
13 3WZK ic50 = 58 nM O23 C21 H19 N5 O S c1cc(sc1)C....
14 5EHY ic50 = 0.81 uM 5O4 C16 H11 N3 O c1ccc(cc1)....
15 5AP1 - O38 C24 H25 N7 O Cn1cc(cn1)....
16 5N84 ic50 = 6.7 nM 8Q5 C20 H23 N5 O CC(C)CNc1c....
17 5EI8 ic50 = 0.008 uM 5OE C22 H20 N8 O Cn1cc(cn1)....
18 5EH0 Ki = 0.0005 uM 5NW C23 H27 N7 O CC(C)(C)CN....
19 4D2S ic50 = 0.02 uM DYK C24 H26 N6 O2 CN1CCC(CC1....
50% Homology Family (19)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 3HMP ic50 = 38.41 uM CX4 C12 H12 Cl N3 c1cc2c(cc1....
2 3HMO ic50 = 0.102 uM STU C28 H26 N4 O3 C[C@@]12[C....
3 5N9S ic50 = 2.4 nM 8QW C29 H26 F N5 O4 S C[C@H](c1c....
4 5N87 ic50 = 0.9 nM N66 C33 H39 N7 O2 CCc1cccc(c....
5 5AP0 - AU5 C24 H32 N6 O3 CN1CCC(CC1....
6 5MRB Kd = 471 nM C5N C33 H40 N8 O2 CCc1cccc(c....
7 4C4J - X21 C26 H26 Cl N7 O2 CC(C)(C)OC....
8 5N93 Ki = 7.7 nM 8QE C17 H20 N6 O CC(C)(C)Nc....
9 4C4F - 7CE C17 H14 N4 O2 COc1ccccc1....
10 5AP6 - PWU C26 H27 N7 O2 Cc1ncc(n1C....
11 5EI6 ic50 = 0.099 uM 5OQ C21 H20 N4 O2 Cn1cc(cn1)....
12 5AP7 - SVE C35 H39 F3 N8 O3 CCc1cccc(c....
13 3WZK ic50 = 58 nM O23 C21 H19 N5 O S c1cc(sc1)C....
14 5EHY ic50 = 0.81 uM 5O4 C16 H11 N3 O c1ccc(cc1)....
15 5AP1 - O38 C24 H25 N7 O Cn1cc(cn1)....
16 5N84 ic50 = 6.7 nM 8Q5 C20 H23 N5 O CC(C)CNc1c....
17 5EI8 ic50 = 0.008 uM 5OE C22 H20 N8 O Cn1cc(cn1)....
18 5EH0 Ki = 0.0005 uM 5NW C23 H27 N7 O CC(C)(C)CN....
19 4D2S ic50 = 0.02 uM DYK C24 H26 N6 O2 CN1CCC(CC1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: DYK; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 DYK 1 1
2 AU5 0.491228 0.869565
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4D2S; Ligand: DYK; Similar sites found: 351
This union binding pocket(no: 1) in the query (biounit: 4d2s.bio1) has 17 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1RDL MMA 0.008306 0.41065 None
2 5C8W PCG 0.003564 0.40864 None
3 5C1P ADP 0.009743 0.40001 1.40845
4 3B6R CRN 0.0003637 0.45801 1.76056
5 2QK4 ATP 0.0006056 0.44429 1.76056
6 4CC6 L5Y 0.007501 0.414 2.11268
7 4EE7 PIS 0.01527 0.4051 2.11268
8 3EXS 5RP 0.005298 0.41216 2.26244
9 1VRP IOM 0.002163 0.44515 2.46479
10 3VPC ADP 0.0005204 0.4151 2.48227
11 1P6O HPY 0.001168 0.42273 3.10559
12 3VV1 GAL FUC 0.0123 0.40819 3.125
13 3ETH ATP 0.001314 0.45332 3.16901
14 3TY5 ATP 0.0007912 0.44523 3.16901
15 3TY5 ADP 0.00282 0.42715 3.16901
16 3I0O ADP 0.00465 0.41926 3.16901
17 1PKX XMP 0.01326 0.40712 3.16901
18 1IA9 ANP 0.001421 0.41199 3.21429
19 1KQB BEZ 0.02116 0.40032 3.22581
20 1KQB FMN 0.01974 0.40032 3.22581
21 1Q6O LG6 0.00445 0.40182 3.24074
22 2GQR ADP 0.01011 0.40363 3.37553
23 4X5S AZM 0.007588 0.42308 3.44828
24 5W2I I3P 0.0002138 0.40764 3.50195
25 5W2I ADP 0.0002138 0.40764 3.50195
26 3UDZ ADP 0.00002103 0.53371 3.52113
27 4AZT LY2 0.000158 0.48827 3.52113
28 3X01 AMP 0.0007626 0.47111 3.52113
29 4LH7 1X8 0.00305 0.43461 3.52113
30 3PN1 IVH 0.004141 0.40282 3.52113
31 4OCJ NDG 0.03547 0.40205 3.52113
32 5EPQ OLA 0.0006624 0.45867 3.65854
33 2PUL ACP 0.00003147 0.48887 3.87324
34 2CFM AMP 0.00009317 0.49905 4.22535
35 1OIJ AKG 0.005156 0.43083 4.22535
36 3WVR AMP 0.003449 0.41414 4.22535
37 4M52 FAD 0.04591 0.40162 4.22535
38 1S68 AMP 0.0004799 0.44045 4.41767
39 5MW8 ATP 0.00003822 0.5286 4.57746
40 3SJK LYS PRO VAL LEU ARG THR ALA 0.00273 0.44716 4.57746
41 1HFU NAG NDG 0.04596 0.40713 4.57746
42 2IO8 ADP 0.0006364 0.40039 4.57746
43 2VQD AP2 0.0009645 0.41054 4.74138
44 2Z49 AMG 0.0009536 0.4537 4.92958
45 2Z48 A2G 0.003397 0.43968 4.92958
46 2Z48 NGA 0.005028 0.42479 4.92958
47 4D52 GIV 0.01577 0.40402 4.92958
48 1NKI PPF 0.0144 0.40472 5.18518
49 5IXH OTP 0.007169 0.44234 5.59006
50 4R78 AMP 0.001571 0.44679 5.6338
51 2R0D 4IP 0.009793 0.41307 5.6338
52 2VPQ ANP 0.0006547 0.46966 5.76497
53 4ZS4 ATP 0.0005173 0.42426 5.98592
54 3PDT ADP 0.002378 0.42086 6.18182
55 1Y0G 8PP 0.03782 0.40517 6.28272
56 5COU ATP 0.000139 0.49016 6.33803
57 4OUC 5ID 0.000001692 0.55679 6.69014
58 2PYW ADP 0.00005824 0.51533 6.69014
59 5TT5 NAD 0.007198 0.42306 6.69014
60 1CKM GTP 0.006807 0.41604 6.69014
61 2D24 XYS XYS 0.016 0.40501 6.69014
62 3LOO B4P 0.03484 0.40146 6.69014
63 3BRN SRO 0.005801 0.42585 7.00637
64 4CYI ATP 0.00001793 0.53951 7.04225
65 5BV6 35G 0.009917 0.40794 7.23684
66 5DMZ ADP 0.000007906 0.50305 7.74648
67 2IF8 ADP 0.0002322 0.49368 7.74648
68 1M0W ANP 0.001981 0.43423 8.09859
69 3TII ANP 0.005892 0.41442 8.09859
70 5TT6 ATP 0.001282 0.40078 8.09859
71 5V3D FCN 0.006215 0.42738 8.27586
72 3AB4 THR 0.008357 0.41173 8.42697
73 5VZ0 ADP 0.0005006 0.46432 8.4507
74 4AZW ATP 0.005118 0.42339 8.4507
75 3LQV ADE 0.008727 0.4178 8.69565
76 5T7I LAT NAG GAL 0.01663 0.40464 8.80282
77 4KAX 4IP 0.01639 0.40191 8.87574
78 4XYM A12 0.001846 0.40562 9.13043
79 3HAV ATP 0.0006508 0.47497 9.15493
80 5I35 ANP 0.0008652 0.43286 9.15493
81 5K2M ADP 0.004976 0.42921 9.43396
82 1IA7 BGC BGC 0.01493 0.40016 9.50704
83 4WVW SLT 0.006293 0.42518 9.85915
84 1CBK ROI 0.0017 0.45408 10
85 4LRJ ANP 0.0001934 0.48349 10.0592
86 3RE4 TO1 0.00007484 0.50351 10.0775
87 1TZD ADP 0.0002124 0.50786 10.1818
88 3KMW ATP 0.0002093 0.45834 10.3321
89 1W2D ADP 0.0003647 0.47121 10.566
90 2BKK ADP 0.007552 0.40509 10.6061
91 3VPB ADP 0.0001736 0.41363 10.7143
92 1NE6 SP1 0.002459 0.4322 10.9541
93 1ZTH ADP 0.0000879 0.48468 12.7907
94 1ZP9 ATP 0.0002146 0.46521 12.7907
95 5IQD GNP 0.03037 0.4045 13.0282
96 5IQD RIO 0.03177 0.4045 13.0282
97 5DXT 5H5 0.0001642 0.49175 14.0845
98 5FI4 5XV 0.003325 0.43763 14.0845
99 3Q60 ATP 0.000009777 0.51155 14.7887
100 2QLU ADE 0.0000003822 0.65382 15.1408
101 4OAV ACP 0.000000865 0.55449 15.1408
102 3C1X CKK 0.00003381 0.45624 15.493
103 5GZ9 ANP 0.000001708 0.59308 15.8451
104 5EOB 5QQ 0.00001544 0.58916 16.1972
105 1VJY 460 0.000000106 0.46312 16.9014
106 4CRL C1I 0.0000003082 0.44648 17.2535
107 4DFU QUE 0.008539 0.41128 17.2535
108 4XH0 ADP 0.0000003093 0.64372 17.9577
109 4I94 ANP 0.000003682 0.56337 17.9577
110 2Y6O 1N1 0.0000007784 0.51602 17.9577
111 2PZI AXX 0.00001958 0.52358 18.662
112 4Y0X ADP 0.00003193 0.51692 18.662
113 4KBA 1QM 0.000009827 0.44363 19.7183
114 5W4W 9WG 0.000002192 0.4423 19.7183
115 4JR7 GNP 0.000001491 0.53114 20.0704
116 4GYI ADP 0.0001055 0.4901 20.7746
117 4BKJ STI 0.0001532 0.41661 20.7746
118 5C4L 4XR 0.02003 0.40808 20.7746
119 3LKJ LKJ 0.01131 0.42162 21.9858
120 4IX4 ADP 0.0005347 0.46981 22.1831
121 4WW7 AMP 0.0005716 0.4705 22.4599
122 5U6C 7YS 0.0000003888 0.52439 22.8873
123 3VHE 42Q 0.000000007067 0.50675 23.2394
124 4ASE AV9 0.0000001332 0.48372 23.2394
125 3PP0 03Q 0.0000005607 0.47722 23.2394
126 4AG8 AXI 0.00000001057 0.46543 23.2394
127 3PLS ANP 0.000006589 0.51999 23.5915
128 4FF8 14S 0.0002132 0.46889 23.5915
129 5UR1 YY9 0.00000007788 0.69389 23.9437
130 4CLI 5P8 0.000000008059 0.74578 24.2958
131 1JPA ANP 0.000001814 0.58425 24.2958
132 1U59 STU 0.0000001511 0.57519 24.2958
133 5MY8 RXZ 0.000005099 0.57505 24.2958
134 3GQI ACP 0.0000001792 0.56542 24.2958
135 5T8O 76Z 0.0000001431 0.54528 24.2958
136 5TO8 7FM 0.000000446 0.4199 24.6479
137 3H9R TAK 0.00000002791 0.6758 25.3521
138 3LXN MI1 0.0000002267 0.53814 25.3521
139 4GJ3 0XP 0.00000001483 0.49178 25.3521
140 4WOV 3SM 0.0000122 0.53299 25.7042
141 4OTH DRN 0.0000006217 0.51364 25.7042
142 5C03 AGS 0.000109 0.45806 25.7042
143 4E1Z 0MX 0.0000006341 0.50612 26.0563
144 4CSV STI 0.000004091 0.47573 26.0563
145 5M06 ADP 0.00003903 0.49743 26.4493
146 5KJZ PCG 0.006166 0.41363 26.6667
147 4L9I 8PR 0.00001308 0.50695 26.7606
148 5JGA 6KC 0.000000005873 0.49093 26.7606
149 1Y57 MPZ 0.000001961 0.48826 27.1127
150 1BYG STU 0.0000002369 0.59418 27.3381
151 2XVD AS6 0.000002323 0.45463 27.8169
152 5FBN 5WF 0.000002241 0.60842 28.0443
153 4O1P ANP 0.0000009309 0.59429 28.169
154 1Q8Y ADP 0.000001481 0.5907 28.169
155 1Q8Y ADE 0.000004566 0.53193 28.169
156 2QX0 PH2 0.00209 0.45001 28.3019
157 4F9C 0SX 0.000005102 0.55679 28.5211
158 4XLI 1N1 0.0000004447 0.56795 28.7313
159 4BHN BH9 0.0000003595 0.53451 28.8732
160 5USZ SKE 0.00000101 0.46898 28.8732
161 1OPK P16 0.00000004635 0.47885 29.2254
162 5UOX 8GY 0.0000001717 0.53414 29.8893
163 1ZY5 ANP 0.00003853 0.51602 29.9296
164 4IDT T28 0.00000002876 0.6157 30.2817
165 4WB6 ATP 0.000001738 0.59989 30.2817
166 1RE8 BD2 0.0000004294 0.66073 30.6338
167 2QCS ANP 0.000001599 0.60164 30.6338
168 3FHI ANP 0.000001768 0.59953 30.6338
169 3IDB ANP 0.000001018 0.495 30.6338
170 4WB7 ATP 0.000004078 0.40384 30.6338
171 1OUK 084 0.00008345 0.58005 32.7465
172 3FHR P4O 0.000000497 0.53992 32.7465
173 5EKO N17 0.0000467 0.52445 32.7465
174 4LOO SB4 0.00003603 0.52011 32.7465
175 2R5T ANP 0.000003385 0.48576 33.4507
176 5LXC 7AA 0.00000005874 0.64305 33.8028
177 4G17 0VN 0.000000878 0.58889 33.8028
178 3GNI ATP 0.000003378 0.49248 33.8028
179 4H3Q ANP 0.00000003718 0.67248 34.1549
180 4M69 ANP 0.000308 0.4287 34.1549
181 5UIU 8CG 0.000002178 0.6015 34.507
182 4EWH T77 0.000001151 0.46462 34.5455
183 2CSN CKI 0.0005692 0.51017 34.8592
184 4Q5H ANP 0.001737 0.40474 35.0575
185 3GC8 B45 0.0000003295 0.52361 35.4054
186 4IJP 1EH 0.0000000007483 0.74653 35.5634
187 4Y85 499 0.00000319 0.53356 35.5634
188 4FL3 ANP 0.0000002647 0.52653 35.5634
189 4IZY 1J2 0.000000008558 0.59835 35.9155
190 4UX9 ANP 0.00000003659 0.56429 35.9155
191 3RI1 3RH 0.0000001025 0.65945 36.1022
192 5BYZ 4WE 0.0000002435 0.45483 36.2069
193 3TKI S25 0.0000001096 0.69979 36.2676
194 2HY0 306 0.00000001484 0.66644 36.2676
195 3PTG 932 0.00000001361 0.64062 36.2676
196 3TTI KBI 0.00000002217 0.51317 36.2676
197 4WHZ 3NL 0.00000002128 0.41489 36.2676
198 3OFM 4B0 0.000002021 0.56874 36.5714
199 4YZC STU 0.0000000136 0.72293 36.6197
200 5AWM ANP 0.00000004542 0.65457 36.6197
201 5KO1 6UY 0.000004511 0.52444 36.7491
202 3ORK AGS 0.00001279 0.44114 36.9718
203 3PE2 E1B 0.000001006 0.64177 37.092
204 2PVN P63 0.00000001168 0.51155 37.2159
205 4NST ADP 0.000003296 0.51885 37.3239
206 5CKW ANP 0.002182 0.42513 37.3239
207 3E7O 35F 0.00000000146 0.5042 37.5
208 5LVP ATP 0.000001799 0.57105 37.6761
209 4EUU BX7 0.0000002163 0.49238 37.6761
210 4NFN 2KC 0.00008138 0.47483 37.6761
211 5EFQ ADP 0.0000009581 0.59371 38.0282
212 3LXK MI1 0.0000002663 0.48614 38.0282
213 2X2M X2M 0.0000000125 0.69198 38.3803
214 2PVF ACP 0.0000001161 0.58921 38.7324
215 4BTK DTQ 0.00001892 0.53318 38.7324
216 5HX8 66P 0.00000002459 0.51967 38.7324
217 4U0I 0LI 0.00000005109 0.47276 39.3651
218 4K33 ACP 0.0000003397 0.61792 39.4366
219 5VC5 96M 0.00000001155 0.70805 39.7887
220 3G5D 1N1 0.0000007888 0.65769 39.7887
221 2H8H H8H 0.0000009928 0.53996 39.7887
222 4E93 GUI 0.00000005139 0.47347 39.7887
223 4Y93 746 0.000002774 0.46003 40.1408
224 5CEO 50D 0.000002635 0.57318 40.493
225 4YZN 4K5 0.00000002338 0.55073 40.493
226 3SXF BK5 0.00000429 0.40641 40.493
227 5LPB ADP 0.0000005635 0.60322 40.8451
228 5LPZ ADP 0.0000007454 0.54628 40.8451
229 4OH4 ANP 0.000001405 0.53608 40.8451
230 4G31 0WH 0.00000252 0.41828 40.8451
231 4P5Z Q7M 0.00000145 0.41472 40.8451
232 2Z7R STU 0.0000000302 0.55759 41.1972
233 5NKB 8ZT 0.00000002936 0.43634 41.1972
234 5JKG 6LF 0.00000002358 0.71293 41.9014
235 5HVJ ANP 0.0000004325 0.64462 41.9014
236 5VCV 1N1 0.00000005711 0.52843 41.9014
237 2OO8 RAJ 0.0001391 0.42898 41.9014
238 3SXS PP2 0.0000002584 0.53832 42.1642
239 3M2W L8I 0.0000001119 0.62628 42.2535
240 3MVH WFE 0.0000007975 0.6229 42.2535
241 3UIM ANP 0.00000571 0.50942 42.2535
242 3AQV TAK 0.00001111 0.54398 42.3913
243 3NW7 LGV 0.0000001904 0.67884 42.6056
244 1K3A ACP 0.000002038 0.56857 42.8571
245 2B9F ADP 0.000000007117 0.69318 42.9577
246 2B9H ADP 0.000000008799 0.69249 42.9577
247 3BU5 ATP 0.00000009927 0.63971 42.9577
248 2B9J ADP 0.00000002589 0.61655 42.9577
249 2B9I ADP 0.00000002956 0.59728 42.9577
250 5MJA 7O3 0.0000006447 0.59507 42.9577
251 4XV1 904 0.00001339 0.56811 42.9577
252 3GC0 AMP 0.000003214 0.55951 42.9577
253 5UKL SIX 0.00002072 0.54973 42.9577
254 4JDI ANP 0.000001256 0.51028 42.9577
255 3EKK GS2 0.000000002868 0.47957 42.9577
256 3PVW QRX 0.000004822 0.45162 42.9577
257 2X4Z X4Z 0.000001549 0.42482 42.9577
258 2F57 23D 0.0000001732 0.6008 43.3099
259 4X7Q 3YR 0.00000005883 0.58791 43.3099
260 5JZJ AN2 0.0000001265 0.58787 43.3099
261 3VRY B43 0.0000003139 0.49645 43.3099
262 4AT3 LTI 0.000003925 0.43355 43.3099
263 2OFV 242 0.0000001173 0.44692 43.3213
264 2XMY CDK 0.00000000651 0.77719 43.662
265 4BCM T7Z 0.000000009986 0.71 43.662
266 4BCN T9N 0.000000003444 0.69549 43.662
267 5HES 032 0.00000001312 0.69098 43.662
268 4CFU 2WC 0.000000003635 0.67294 43.662
269 5LMK 6ZK 0.00000004722 0.64742 43.662
270 4BCQ TJF 0.0000002778 0.59624 43.662
271 4NW6 2NS 0.0000001598 0.45477 43.662
272 2BPM 529 0.000000004329 0.42114 43.662
273 4CQE CQE 0.00002044 0.46009 43.8849
274 3KRR DQX 0.00000003043 0.74047 44.0141
275 1U5R ATP 0.00000006119 0.58415 44.0141
276 3V8S 0HD 0.0000002521 0.57473 44.0141
277 1XJD STU 0.0000002184 0.55286 44.0141
278 5H2U 1N1 0.000000205 0.57165 44.1948
279 3SRV S19 0.0000001281 0.63108 44.4043
280 5DA3 58V 0.000000005052 0.69936 44.5283
281 5JFS 6K0 0.000001159 0.63117 44.7183
282 4N70 2HX 0.0000025 0.62418 44.7183
283 5DBX ANP 0.000001616 0.57319 44.7183
284 2WEI VGG 0.00000583 0.53346 44.7183
285 3CY2 MB9 0.000001004 0.50159 44.7183
286 3IGO ANP 0.000002347 0.49003 44.7183
287 4F4P 0SB 0.000006745 0.61224 45.0549
288 3F7Z 34O 0.00000009702 0.64017 45.0704
289 5L8L ADP 0.0000004085 0.60978 45.0704
290 4H3P ANP 0.0000001259 0.57395 45.0704
291 5G1X ADP 0.0000006249 0.56006 45.0704
292 4FG8 ATP 0.000006933 0.55902 45.0704
293 5LXM ADP 0.0000008919 0.55438 45.0704
294 2A19 ANP 0.0000141 0.53755 45.0704
295 4NM5 ADP 0.00000008218 0.53286 45.0704
296 4WNK 453 0.000007792 0.42922 45.0704
297 4YMJ 4EJ 0.0000002583 0.64708 45.4225
298 2VN9 GVD 0.00000005116 0.61224 45.4225
299 2WEL K88 0.00000002881 0.58776 45.4225
300 3KRL KRL 0.00000002561 0.56028 45.4225
301 2HK5 1BM 0.000001071 0.59737 45.5556
302 5EW9 5VC 0.000002984 0.66016 45.7565
303 3ZRM ZRM 0.0000001847 0.62711 45.7746
304 3TXO 07U 0.0000008452 0.58965 45.7746
305 2V7O DRN 0.0000002336 0.58382 45.7746
306 2VZ6 FEF 0.000006294 0.54615 45.7746
307 3ALN ANP 0.000001726 0.51048 45.7746
308 2JLD AG1 0.000000005842 0.49228 45.7746
309 4WNP 3RJ 0.000000009415 0.67549 46.1268
310 4C2W ANP 0.00000008161 0.61804 46.1268
311 1CM8 ANP 0.000000558 0.60141 46.1268
312 4I6H 1C8 0.000002403 0.52978 46.1268
313 3SLS ANP 0.00000049 0.5152 46.1268
314 4C2V YJA 0.00000001189 0.50637 46.1268
315 5TA6 79D 0.00000009952 0.50418 46.1268
316 4KS7 X4Z 0.00000073 0.50347 46.1268
317 3E5A VX6 0.0000008824 0.48552 46.2687
318 1UNH IXM 0.0000000002756 0.74571 46.4789
319 4AU8 Z3R 0.000000001385 0.72575 46.4789
320 3O0G 3O0 0.000000002206 0.71297 46.4789
321 4L3L 5FI 0.0000001021 0.66668 46.4789
322 4U44 3D9 0.0000002183 0.62372 46.4789
323 3HZT J60 0.0000006578 0.60006 46.4789
324 3KN5 ANP 0.000002956 0.56117 46.4789
325 2XK9 XK9 0.005609 0.46856 46.4789
326 5EYK 5U5 0.0000001725 0.4888 46.7391
327 1V0O INR 0.0000000009418 0.64024 46.831
328 3DLS ADP 0.000000602 0.59645 46.831
329 3DAK ANP 0.000001643 0.55586 46.831
330 2WQN ADP 0.0000296 0.51536 46.831
331 5DH3 5BS 0.000001484 0.51044 46.831
332 2RIO ADP 0.0000003296 0.61202 47.1831
333 3C0G 3AM 0.000005014 0.55067 47.1831
334 4A4X JUP 0.0000001534 0.49912 47.3118
335 5AX9 4KT 0.0000001643 0.5718 47.5352
336 5IH9 6BF 0.0000002647 0.6565 47.8873
337 5HQ0 LZ9 0.000000000782 0.62671 47.8873
338 4AUA 4AU 0.00000002191 0.62239 47.8873
339 3GGF GVD 0.00000008876 0.61389 47.8873
340 4QTB 38Z 0.0000000017 0.75128 48.2394
341 5LI1 ANP 0.0000002253 0.6323 48.2394
342 1PHK ATP 0.0000004054 0.61431 48.2394
343 4DC2 ADE 0.000000006838 0.58836 48.2394
344 4USF 6UI 0.00004894 0.52562 48.2394
345 5LI9 ACP 0.000002835 0.50818 48.2394
346 2YAK OSV 0.000001874 0.43832 48.2394
347 5A6N U7E 0.000002584 0.57649 48.5915
348 4BFM ANP 0.0000004293 0.52838 48.5915
349 2YAB AMP 0.000004337 0.50366 48.9437
350 4QMN DB8 0.000003336 0.41076 49.2958
351 4Y8D 49J 0.000000005139 0.6328 49.6479
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