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Receptor
PDB id Resolution Class Description Source Keywords
4CVZ 2.39 Å NON-ENZYME: IMMUNE COMPLEX OF A B21 CHICKEN MHC CLASS I MOLECULE AND A 10MER CHICKEN PEPTIDE GALLUS GALLUS IMMUNE SYSTEM MHC B21
Ref.: EXPRESSION LEVELS OF MHC CLASS I MOLECULES ARE INVE CORRELATED WITH PROMISCUITY OF PEPTIDE BINDING. ELIFE V. 4 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EDO A:1279;
B:1101;
A:1280;
B:1102;
B:1100;
B:1099;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU C:1;
Valid;
none;
submit data
1325.44 n/a O=C([...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4CVZ 2.39 Å NON-ENZYME: IMMUNE COMPLEX OF A B21 CHICKEN MHC CLASS I MOLECULE AND A 10MER CHICKEN PEPTIDE GALLUS GALLUS IMMUNE SYSTEM MHC B21
Ref.: EXPRESSION LEVELS OF MHC CLASS I MOLECULES ARE INVE CORRELATED WITH PROMISCUITY OF PEPTIDE BINDING. ELIFE V. 4 2015
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 208 families.
1 4CVZ - TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU n/a n/a
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 4G43 - ILE ASP TRP PHE GLU GLY LYS GLU n/a n/a
2 4E0R - ILE ASP TRP PHE ASP GLY LYS GLU n/a n/a
3 4G42 - ILE ASP TRP PHE ASP GLY LYS ASP n/a n/a
4 4CVZ - TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU n/a n/a
50% Homology Family (366)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 42 families.
1 4QRT - GLU LEU ASN ARG LYS MET ILE TYR MET n/a n/a
2 3KPN - GLU GLU TYR LEU GLN ALA PHE THR TYR n/a n/a
3 4U1H - THR PRO GLN ASP LEU ASN THR MET LEU n/a n/a
4 3LKP - LEU PRO PHE ASP LYS SER THR ILE MET n/a n/a
5 1A9E - LEU PRO PRO LEU ASP ILE THR PRO TYR n/a n/a
6 1W0W - ARG ARG LEU PRO ILE PHE SER ARG LEU n/a n/a
7 4G8I - LYS ARG TRP ILE ILE MET GLY LEU ASN LYS n/a n/a
8 5IND - GLN ALA SER GLN ASP VAL LYS ASN TRP n/a n/a
9 2BVP - ILE SER PRO ARG THR LEU ASP ALA TRP n/a n/a
10 5V5L - THR SER THR LEU GLN GLU GLN ILE GLY TRP n/a n/a
11 5DEG - ARG ARG LYS TRP ARG ARG TRP HIS LEU n/a n/a
12 1UXS - ARG ARG ARG TRP ARG ARG LEU THR VAL n/a n/a
13 3VRJ - LEU THR THR LYS LEU THR ASN THR ASN ILE n/a n/a
14 3BP4 - ILE ARG ALA ALA PRO PRO PRO LEU PHE n/a n/a
15 3X12 - LEU SER SER PRO VAL THR LYS SER PHE n/a n/a
16 4O2C ic50 = 10 nM ACE SER HIS VAL ALA VAL GLU ASN ALA LEU n/a n/a
17 5WMP - THR PRO ARG VAL THR GLY GLY GLY ALA MET n/a n/a
18 5DEF - ARG ARG LYS TRP ARG ARG TRP HIS LEU n/a n/a
19 4U1M - ARG PRO GLN VAL PRO LEU ARG PRO MET n/a n/a
20 5IM7 - GLN ALA SER GLN GLU VAL LYS ASN TRP n/a n/a
21 1A1N - VAL PRO LEU ARG PRO MET THR TYR n/a n/a
22 1OGT - ARG ARG LYS TRP ARG ARG TRP HIS LEU n/a n/a
23 3KPO - GLU GLU TYR LEU LYS ALA TRP THR PHE n/a n/a
24 5WMR - GLN ILE LYS VAL ARG VAL ASP MET VAL n/a n/a
25 2A83 - ARG ARG ARG TRP HIS ARG TRP ARG LEU n/a n/a
26 3B6S - ARG ARG LYS TRP CIR ARG TRP HIS LEU n/a n/a
27 1JGD - ARG ARG LEU LEU ARG GLY HIS ASN GLN TYR n/a n/a
28 5EO0 - ARG PRO MET THR PHE LYS GLY ALA LEU n/a n/a
29 1HSA - ALA ARG ALA ALA ALA ALA ALA ALA ALA n/a n/a
30 1AGE - GLY GLY LYS LYS LYS TYR ARG LEU n/a n/a
31 4JQV - SER GLU LEU GLU ILE LYS ARG TYR n/a n/a
32 3X11 - LEU SER SER PRO VAL THR LYS SER PHE n/a n/a
33 1M6O - GLU GLU PHE GLY ARG ALA PHE SER PHE n/a n/a
34 4G9D - LYS ARG TRP ILE ILE LEU GLY LEU ASN LYS n/a n/a
35 6BXP - ARG VAL LYS GLU LYS TYR GLN HIS LEU KYN n/a n/a
36 3LKR - LEU PRO PHE GLU ARG ALA THR VAL MET n/a n/a
37 3KPP - GLU GLU TYR LEU GLN ALA PHE THR TYR n/a n/a
38 1K5N - GLY ARG PHE ALA ALA ALA ILE ALA LYS n/a n/a
39 4O2E - SER HIS VAL ALA VAL GLU ASN ALA LEU n/a n/a
40 4U1N - ARG PRO GLN VAL PRO LEU ARG PRO MET n/a n/a
41 3BP7 - ILE ARG ALA ALA PRO PRO PRO LEU PHE n/a n/a
42 1XR9 - ILE LEU GLY PRO PRO GLY SER VAL TYR n/a n/a
43 5WMN - SER PRO ILE VAL PRO SER PHE ASP MET n/a n/a
44 1AGD - GLY GLY LYS LYS LYS TYR LYS LEU n/a n/a
45 3LKO - LEU PRO PHE ASP ARG THR THR ILE MET n/a n/a
46 1SYS - GLU GLU PRO THR VAL ILE LYS LYS TYR n/a n/a
47 3KPM - GLU GLU TYR LEU LYS ALA TRP THR PHE n/a n/a
48 4U1S - PHE PRO ARG PRO TRP LEU HIS GLY LEU n/a n/a
49 4U1K - ARG PRO GLN VAL PRO LEU ARG PRO MET n/a n/a
50 5U98 Kd = 0.2 nM VAL THR THR ASP ILE GLN VAL LYS VAL n/a n/a
51 2H6P - LYS PRO ILE VAL VAL LEU HIS GLY TYR n/a n/a
52 4XXC - ASP GLU LEU GLU ILE LYS ALA TYR n/a n/a
53 3UPR - HIS SER ILE THR TYR LEU LEU PRO VAL n/a n/a
54 4QRQ Kd = 2.48 uM HIS SER LYS LYS LYS CYS ASP GLU LEU n/a n/a
55 3X13 - PHE LEU ARG GLY ARG ALA TYR GLY LEU n/a n/a
56 3VRI - ARG VAL ALA GLN LEU GLU GLN VAL TYR ILE n/a n/a
57 3LV3 - SER ARG ARG TRP ARG ARG TRP ASN ARG n/a n/a
58 1UXW - ARG ARG ARG TRP ARG ARG LEU THR VAL n/a n/a
59 1XR8 - LEU GLU LYS ALA ARG GLY SER THR TYR n/a n/a
60 1AGC - GLY GLY LYS LYS LYS TYR GLN LEU n/a n/a
61 5WMO - ARG PRO PRO ILE PHE ILE ARG ARG LEU n/a n/a
62 1A1M - THR PRO TYR ASP ILE ASN GLN MET LEU n/a n/a
63 4U1L - ARG PRO GLN VAL PRO LEU ARG PRO MET n/a n/a
64 3SKO - PHE LEU ARG GLY ARG ALA TYR GLY LEU n/a n/a
65 3BXN - ILE ARG ALA ALA PRO PRO PRO LEU PHE n/a n/a
66 1A1O - LYS PRO ILE VAL GLN TYR ASP ASN PHE n/a n/a
67 3DX7 - GLU GLU ASN LEU LEU ASP PHE VAL ARG PHE n/a n/a
68 5W67 - VAL ARG SER ARG ARG ABA LEU ARG LEU n/a n/a
69 5EO1 - ARG PRO MET THR TYR LYS GLY ALA LEU n/a n/a
70 1M05 - PHE LEU ARG GLY ARG ALA TYR GLY LEU n/a n/a
71 5TXS - ALA GLN ASP ILE TYR ARG ALA SER TYR n/a n/a
72 2BSR - ARG ARG ILE TYR ASP LEU ILE GLU LEU n/a n/a
73 5WMQ - GLU LEU ARG SER ARG TYR TRP ALA ILE n/a n/a
74 4QRS - GLU LEU LYS ARG LYS MET ILE TYR MET n/a n/a
75 2BST - SER ARG TYR TRP ALA ILE ARG THR ARG n/a n/a
76 4U1I - THR PRO GLN ASP LEU ASN THR MET LEU n/a n/a
77 6BXQ - ARG VAL LYS GLU LYS TYR GLN HIS LEU TRP n/a n/a
78 1AGB - GLY GLY ARG LYS LYS TYR LYS LEU n/a n/a
79 3LKQ - LEU PRO PHE ASP LYS THR THR ILE MET n/a n/a
80 2AXG - ALA PRO GLN PRO ALA PRO GLU ASN ALA TYR n/a n/a
81 3DX6 - GLU GLU ASN LEU LEU ASP PHE VAL ARG PHE n/a n/a
82 1AGF - GLY GLY LYS LYS ARG TYR LYS LEU n/a n/a
83 2CIK - LYS PRO ILE VAL VAL LEU HIS GLY TYR n/a n/a
84 3LKN - LEU PRO PHE GLU ARG ALA THR ILE MET n/a n/a
85 2BSS - LYS ARG TRP ILE ILE LEU GLY LEU ASN LYS n/a n/a
86 3C9N - VAL GLN GLN GLU SER SER PHE VAL MET n/a n/a
87 4U1J - THR PRO GLN ASP LEU ASN THR MET LEU n/a n/a
88 3B3I - ARG ARG LYS TRP CIR ARG TRP HIS LEU n/a n/a
89 3DX8 - GLU GLU ASN LEU LEU ASP PHE VAL ARG PHE n/a n/a
90 3KPL - GLU GLU TYR LEU GLN ALA PHE THR TYR n/a n/a
91 5VGD - SER ALA GLU PRO VAL PRO LEU GLN LEU n/a n/a
92 1OF2 - ARG ARG LYS TRP ARG ARG TRP HIS LEU n/a n/a
93 1W0V - ARG ARG LEU PRO ILE PHE SER ARG LEU n/a n/a
94 1E27 - LEU PRO PRO VAL VAL ALA LYS GLU ILE n/a n/a
95 1JGE - GLY ARG PHE ALA ALA ALA ILE ALA LYS n/a n/a
96 5T6W - SER SER THR ARG GLY ILE SER GLN LEU TRP n/a n/a
97 3X14 - PHE LEU ARG GLY ARG ALA TYR GLY LEU n/a n/a
98 1N2R - GLU GLU PHE GLY ARG ALA PHE SER PHE n/a n/a
99 4QRU - GLU LEU ARG ARG LYS MET MET TYR MET n/a n/a
100 5W6A - ALA ARG THR GLU LEU TYR ARG SER LEU n/a n/a
101 2AXF - ALA PRO GLN PRO ALA PRO GLU ASN ALA TYR n/a n/a
102 4NT6 - GLY ILE LEU GLY PHE VAL PHE THR LEU n/a n/a
103 3BWA - PHE PRO THR LYS ASP VAL ALA LEU n/a n/a
104 5T6X - THR SER THR THR SER VAL ALA SER SER TRP n/a n/a
105 4O2F - HIS VAL ALA VAL GLU ASN ALA LEU n/a n/a
106 3SKM - PHE LEU ARG GLY ARG ALA TYR VAL LEU n/a n/a
107 1SYV - GLU GLU PHE GLY ARG ALA PHE SER PHE n/a n/a
108 3KPQ - GLU GLU TYR LEU LYS ALA TRP THR PHE n/a n/a
109 3LKS - LEU PRO PHE GLU LYS SER THR VAL MET n/a n/a
110 1B0G - ALA LEU TRP GLY PHE PHE PRO VAL LEU n/a n/a
111 3GSW - ASN LEU VAL PRO MET VAL ALA ALA VAL n/a n/a
112 5HGA - ARG PHE PRO LEU THR PHE GLY TRP n/a n/a
113 2X4O - LYS LEU THR PRO LEU CYS VAL THR LEU n/a n/a
114 5N6B - LEU LEU TRP ASN GLY PRO MET ALA VAL n/a n/a
115 1QR1 - ILE ILE SER ALA VAL VAL GLY ILE LEU n/a n/a
116 3O3B - GLU LEU ALA GIC 3AZ LEU THR VAL n/a n/a
117 5C0I - ARG GLN PHE GLY PRO ASP PHE PRO THR ILE n/a n/a
118 5N1Y - MET VAL TRP GLY PRO ASP PRO LEU TYR VAL n/a n/a
119 5GSD - SER SER CYS PRO LEU SER LYS n/a n/a
120 1I1Y - TYR LEU LYS GLU PRO VAL HIS GLY VAL n/a n/a
121 3FT3 ic50 = 44 nM VAL LEU HIS ASP ASP LEU LEU GLU ALA n/a n/a
122 2VLL - GLY ILE LEU GLY PHE VAL PHE THR LEU n/a n/a
123 1T1Z - ALA LEU TYR ASN THR ALA ALA ALA LEU n/a n/a
124 3FQT - GLY LEU LEU GLY SER PRO VAL ARG ALA n/a n/a
125 3GSQ - ASN LEU VAL PRO SER VAL ALA THR VAL n/a n/a
126 4NQX - CYS THR GLU LEU LYS LEU ASN ASP TYR n/a n/a
127 3VXN - ARG TYR PRO LEU THR PHE GLY TRP CYS PHE n/a n/a
128 5C0J - ARG GLN PHE GLY PRO ASP TRP ILE VAL ALA n/a n/a
129 1DUZ - LEU LEU PHE GLY TYR PRO VAL TYR VAL n/a n/a
130 3H7B Kd = 41 uM MET LEU TRP GLY TYR LEU GLN TYR VAL n/a n/a
131 3WL9 - ASN TYR THR PRO GLY PRO GLY ILE ARG PHE n/a n/a
132 4JFP - GLU LEU ALA ALA ILE GLY ILE LEU THR VAL n/a n/a
133 3FQW - ARG VAL ALA SER PRO THR SER GLY VAL n/a n/a
134 1TVB - ILE THR ASP GLN VAL PRO PHE SER VAL n/a n/a
135 1T1W - SER LEU PHE ASN THR ILE ALA VAL LEU n/a n/a
136 5C0F - ARG GLN TRP GLY PRO ASP PRO ALA ALA VAL n/a n/a
137 3MYJ - TYR MET PHE PRO ASN ALA PRO TYR LEU n/a n/a
138 4WJ5 ic50 = 0.51 uM GRN NVA ALA GLY ILE GLY ILE LEU THR LPH n/a n/a
139 1Q94 - ALA ILE PHE GLN SER SER MET THR LYS n/a n/a
140 3H9H Kd = 5.4 uM MET LEU TRP GLY TYR LEU GLN TYR VAL n/a n/a
141 3O3E - BAL LEU ALA TIG 3AZ LEU THR VAL n/a n/a
142 4I4W - ILE LEU ALA LYS PHE LEU HIS ARG LEU n/a n/a
143 2X4R - ASN LEU VAL PRO MET VAL ALA THR VAL n/a n/a
144 4HWZ - ALA ILE PHE GLN SER SER MET THR LYS n/a n/a
145 3PWJ Kd = 70 uM LEU LEU TYR GLY PHE VAL ASN TYR VAL n/a n/a
146 3FQN - TYR LEU ASP SER GLY ILE HIS SER GLY ALA n/a n/a
147 3BHB ic50 = 3.4 nM LYS MET ASP SEP PHE LEU ASP MET GLN LEU n/a n/a
148 1S9W - SER LEU LEU MET TRP ILE THR GLN CYS n/a n/a
149 5C0G - TYR LEU GLY GLY PRO ASP PHE PRO THR ILE n/a n/a
150 4HX1 - SER VAL TYR ASP PHE PHE VAL TRP LEU n/a n/a
151 3MGO - ARG LEU TYR GLN ASN PRO THR THR TYR ILE n/a n/a
152 1I7R - PHE ALA PRO GLY PHE PHE PRO TYR LEU n/a n/a
153 1X7Q - LYS THR PHE PRO PRO THR GLU PRO LYS n/a n/a
154 3WLB - ASN TYR THR PRO GLY PRO GLY THR ARG PHE n/a n/a
155 3RL2 - GLN VAL PRO LEU ARG PRO MET THR TYR LYS n/a n/a
156 2GUO - ALA ALA GLY ILE GLY ILE LEU THR VAL n/a n/a
157 4JFQ - GLU LEU ALA GLY ILE GLY ILE ALA THR VAL n/a n/a
158 5EU4 - TYR LEU ALA PRO GLY PRO VAL THR ALA n/a n/a
159 1I7U - ALA LEU TRP GLY PHE VAL PRO VAL LEU n/a n/a
160 5C0D - ALA GLN TRP GLY PRO ASP PRO ALA ALA ALA n/a n/a
161 3GSO Kd = 27.7 uM ASN LEU VAL PRO MET VAL ALA THR VAL n/a n/a
162 3HPJ - ARG MET PHE PRO ASN ALA PRO TYR LEU n/a n/a
163 3KLA Kd = 31.1 uM SER LEU LEU MET TRP ILE THR GLN LEU n/a n/a
164 4K7F - VAL CYS TRP GLY GLU LEU MET ASN LEU n/a n/a
165 2V2W Kd = 2.2 uM SER LEU TYR ASN THR VAL ALA THR LEU n/a n/a
166 5SWQ - CYS VAL ASN GLY SER CYS PHE THR VAL n/a n/a
167 3I6L - GLN PHE LYS ASP ASN VAL ILE LEU LEU n/a n/a
168 1QVO - GLN VAL PRO LEU ARG PRO MET THR TYR LYS n/a n/a
169 2GIT - LEU LEU PHE GLY LYS PRO VAL TYR VAL n/a n/a
170 5EU5 - TYR LEU GLU PRO ALA PRO VAL THR ALA n/a n/a
171 2X70 - LYS ILE LEU GLY PRV VAL PHE PRQ VAL n/a n/a
172 2GTZ - ALA LEU GLY ILE GLY ILE LEU THR VAL n/a n/a
173 3OXR - PHE LEU PRO SER ASP PHE PHE PRO SER VAL n/a n/a
174 1T1Y - SER LEU TYR ASN VAL VAL ALA THR LEU n/a n/a
175 1EEZ - ILE LEU SER ALA LEU VAL GLY ILE LEU n/a n/a
176 1TVH - ILE MET ASP GLN VAL PRO PHE SER VAL n/a n/a
177 3REW Kd = 28.8 uM CYS LEU GLY GLY LEU LEU THR MET VAL n/a n/a
178 5MEQ Kd = 28 uM ILE LEU ALA LYS PHE LEU HIS THR LEU n/a n/a
179 3I6G - GLY LEU MET TRP LEU SER TYR PHE VAL n/a n/a
180 5NMH - SER LEU TYR ASN THR ILE ALA THR LEU n/a n/a
181 2C7U Kd = 100 nM SER LEU PHE ASN THR ILE ALA VAL LEU n/a n/a
182 1EEY - ILE LEU SER ALA LEU VAL GLY ILE VAL n/a n/a
183 1HHJ - ILE LEU LYS GLU PRO VAL HIS GLY VAL n/a n/a
184 5HGB - ARG TYR PRO LEU THR PHE GLY TRP n/a n/a
185 2GTW - LEU ALA GLY ILE GLY ILE LEU THR VAL n/a n/a
186 3GSV Kd = 57.5 uM ASN LEU VAL PRO GLN VAL ALA THR VAL n/a n/a
187 3D25 ic50 = 22 nM VAL LEU HIS ASP ASP LEU LEU GLU ALA n/a n/a
188 5EU3 - TYR LEU GLU PRO GLY PRO VAL THR ALA n/a n/a
189 3BH9 ic50 = 116.9 nM ARG THR TYR SEP GLY PRO MET ASN LYS VAL n/a n/a
190 3OXS - PHE LEU PRO SER ASP PHE PHE PRO SER VAL n/a n/a
191 2V2X Kd = 5.2 uM SER LEU PHE ASN THR VAL ALA THR LEU n/a n/a
192 4JFO Kd = 140 uM ALA LEU ALA GLY ILE GLY ILE LEU THR VAL n/a n/a
193 5HHP - GLY ILE LEU GLU PHE VAL PHE THR LEU n/a n/a
194 4GKS - PHE LEU THR GLY ILE GLY ILE ILE THR VAL n/a n/a
195 1T20 - SER LEU TYR ASN THR ILE ALA THR LEU n/a n/a
196 3GIV - SER LEU PHE ASN THR VAL ALA THR LEU TYR n/a n/a
197 3VXP - ARG TYR PRO LEU THR LEU GLY TRP CYS PHE n/a n/a
198 3PWL Kd = 140 uM LEU GLY TYR GLY PHE VAL ASN TYR ILE n/a n/a
199 5NMK - SER LEU PHE ASN THR ILE ALA VAL LEU n/a n/a
200 5C0E - TYR GLN PHE GLY PRO ASP PHE PRO ILE ALA n/a n/a
201 3UTQ - ALA LEU TRP GLY PRO ASP PRO ALA ALA ALA n/a n/a
202 4F7P - PHE TYR ARG TYR GLY PHE VAL ALA ASN PHE n/a n/a
203 3RL1 - ALA ILE PHE GLN SER SER MET THR LYS n/a n/a
204 5HGH - ARG TYR PRO LEU THR PHE GLY TRP CYS PHE n/a n/a
205 3QFD Kd = 68 uM ALA ALA GLY ILE GLY ILE LEU THR VAL n/a n/a
206 3O3A - BAL LEU ALA GIC 3AZ LEU THR VAL n/a n/a
207 2X4N - LYS ILE LEU GLY PRV VAL PHE PRQ VAL n/a n/a
208 4F7T - ARG TYR GLY PHE VAL ALA ASN PHE n/a n/a
209 5GRD - SER SER CYS SER SER CYS PRO LEU SER LYS n/a n/a
210 5MEO Kd = 1 uM ILE LEU GLY LYS PHE LEU HIS ARG LEU n/a n/a
211 3GSU Kd = 58.2 uM ASN LEU VAL PRO THR VAL ALA THR VAL n/a n/a
212 5HGD - ARG PHE PRO LEU THR PHE GLY TRP CYS PHE n/a n/a
213 3IXA Kd = 9.8 uM LEU LEU PHE GLY TYR PRO VAL TYR VAL n/a n/a
214 3FT2 ic50 = 44 nM VAL LEU CIR ASP ASP LEU LEU GLU ALA n/a n/a
215 2GT9 - GLU ALA ALA GLY ILE GLY ILE LEU THR VAL n/a n/a
216 5MER - ILE LEU ALA LYS PHE LEU HIS GLU LEU n/a n/a
217 5HHN - GLY ILE LEU GLY LEU VAL PHE THR LEU n/a n/a
218 2CLR - MET LEU LEU SER VAL PRO LEU LEU LEU GLY n/a n/a
219 1T22 - SER LEU TYR ASN THR VAL ALA THR LEU n/a n/a
220 1I4F - GLY VAL TYR ASP GLY ARG GLU HIS THR VAL n/a n/a
221 3NFN - ARG TYR PRO LEU THR PHE GLY TRP CYS PHE n/a n/a
222 3FQU - GLY LEU LEU GLY SEP PRO VAL ARG ALA n/a n/a
223 1JF1 - GLU LEU ALA GLY ILE GLY ILE LEU THR VAL n/a n/a
224 1HHK - LEU LEU PHE GLY TYR PRO VAL TYR VAL n/a n/a
225 3BH8 ic50 = 11.2 nM ARG GLN ALA SEP ILE GLU LEU PRO SER MET n/a n/a
226 3BGM ic50 = 32.5 nM ARG GLN ALA SEP LEU SER ILE SER VAL n/a n/a
227 3O3D - GLU LEU ALA TIG 3AZ LEU THR VAL n/a n/a
228 3PWN Kd = 48 uM LEU LEU TYR GLY PHE VAL ASN TYR ILE n/a n/a
229 3MGT - LYS LEU TYR GLN ASN PRO THR THR TYR ILE n/a n/a
230 3FQX - ARG VAL ALA SEP PRO THR SER GLY VAL n/a n/a
231 1S9Y - SER LEU LEU MET TRP ILE THR GLN SER n/a n/a
232 2AV7 - LEU LEU PHE GLY TYR PRO VAL TYR VAL n/a n/a
233 1S8D - SER LEU ALA ASN THR VAL ALA THR LEU n/a n/a
234 4F7M - LEU TYR ALA SER PRO GLN LEU GLU GLY PHE n/a n/a
235 3OX8 - PHE LEU PRO SER ASP PHE PHE PRO SER VAL n/a n/a
236 3GSX - ASN LEU VAL PRO MET VAL ALA VAL VAL n/a n/a
237 1T1X - SER LEU TYR LEU THR VAL ALA THR LEU n/a n/a
238 1DUY - LEU PHE GLY TYR PRO VAL TYR VAL n/a n/a
239 1S9X - SER LEU LEU MET TRP ILE THR GLN ALA n/a n/a
240 2X4P - MSE ILE LEU GLY PRV VAL PHE PRQ VAL n/a n/a
241 3FT4 ic50 = 1171 nM VAL LEU ARG ASP ASP LEU LEU GLU ALA n/a n/a
242 1HHI - GLY ILE LEU GLY PHE VAL PHE THR LEU n/a n/a
243 1JHT - ALA LEU GLY ILE GLY ILE LEU THR VAL n/a n/a
244 2X4U - ILE LEU LYS GLU PRO VAL HIS GLY VAL n/a n/a
245 4NQV - CYS THR GLU LEU LYS LEU SER ASP TYR n/a n/a
246 5HHQ - GLY ILE TRP GLY PHE VAL PHE THR LEU n/a n/a
247 1T21 - SER LEU TYR ASN THR VAL ALA THR LEU n/a n/a
248 3BO8 - GLU ALA ASP PRO THR GLY HIS SER TYR n/a n/a
249 2AV1 - LEU LEU PHE GLY TYR PRO VAL TYR VAL n/a n/a
250 3GSR Kd = 60.2 uM ASN LEU VAL PRO VAL VAL ALA THR VAL n/a n/a
251 1QEW - PHE LEU TRP GLY PRO ARG ALA LEU VAL n/a n/a
252 1HSB - ALA VAL ALA n/a n/a
253 2HN7 ic50 = 31 nM ALA ILE MET PRO ALA ARG PHE TYR PRO LYS n/a n/a
254 3FQR - TYR LEU ASP SEP GLY ILE HIS SER GLY ALA n/a n/a
255 5GRG - SER SER CYS SER SER CYS n/a n/a
256 2RFX - LEU SER SER PRO VAL THR LYS SER PHE n/a n/a
257 5VCL - ALA MET ALA PRO ARG THR LEU LEU LEU n/a n/a
258 3VJ6 Kd = 17 uM ALA MET ALA PRO ARG THR LEU LEU LEU n/a n/a
259 1WBZ - SER SER TYR ARG ARG PRO VAL GLY ILE n/a n/a
260 1VAD - SER ARG ASP HIS SER ARG THR PRO MET n/a n/a
261 1FZM Kd = 20 nM ARG GLY TYR VAL TYR GLN GLY LEU n/a n/a
262 4PV8 - ARG ABA PHE ILE PHE ALA ASN ILE n/a n/a
263 2ZSV - ARG ABA GLN ILE PHE ALA ASN ILE n/a n/a
264 2CLZ - ILE ASN PHE ASP PHE ASN THR ILE n/a n/a
265 1RK1 - SER GLU ILE GLU PHE ALA ARG LEU n/a n/a
266 3PAB Kd = 20 uM GLU ILE ILE ASN PHE GLU LYS LEU n/a n/a
267 1G7Q Kd = 877 nM SER ALA PRO ASP THR ARG PRO ALA n/a n/a
268 1FZO Kd = 13 nM PHE ALA PRO GLY ASN TYR PRO ALA LEU n/a n/a
269 4HS3 - ALA VAL TYR ASN PHE ALA THR MET n/a n/a
270 4PV9 - ARG ABA VAL ILE PHE ALA ASN ILE n/a n/a
271 1LEK Kd = 1.3 nM GLU GLN TYR LYS PHE TYR SER VAL n/a n/a
272 4PG9 - PHE ALA PRO GLY ASN TYR PRO ALA LEU n/a n/a
273 1NAN - ILE ASN PHE ASP PHE ASN THR ILE n/a n/a
274 2VAA - ARG GLY TYR VAL TYR GLN GLY LEU n/a n/a
275 2VAB - PHE ALA PRO GLY ASN TYR PRO ALA LEU n/a n/a
276 2CLV - SER GLN TYR TYR TYR ASN SER LEU n/a n/a
277 1KJ3 - LYS VAL ILE THR PHE ILE ASP LEU n/a n/a
278 1RJY - SER SER ILE GLU PHE ALA ARG LEU n/a n/a
279 1FZJ Kd = 8 nM ARG GLY TYR VAL TYR GLN GLY LEU n/a n/a
280 1G7P Kd = 90 nM SER ARG ASP HIS SER ARG THR PRO MET n/a n/a
281 1KPU - ARG GLY TYR VAL TYR GLN GLY LEU n/a n/a
282 1T0N - SER SER ILE GLU PHE ALA ARG LEU n/a n/a
283 3P9L Kd = 6 uM SER ILE ILE ASN PHE GLU LYS LEU n/a n/a
284 1T0M - SER SER ILE GLU PHE ALA ARG LEU n/a n/a
285 1FZK Kd = 4 nM PHE ALA PRO GLY ASN TYR PRO ALA LEU n/a n/a
286 1KPV - PHE ALA PRO GLY ASN TYR PRO ALA LEU n/a n/a
287 1OSZ - ARG GLY TYR LEU TYR GLN GLY LEU n/a n/a
288 1LK2 ic50 = 12 uM GLY ASN TYR SER PHE TYR ALA LEU n/a n/a
289 1LEG Kd = 11.1 nM GLU GLN TYR LYS PHE TYR SER VAL n/a n/a
290 1KBG - ARG GLY TYR VAL TYR ESC GLY LEU GAL GLA n/a n/a
291 4PGE - PHE ALA PRO GLY ASN TYR PRO ALA TRP n/a n/a
292 3P9M Kd = 10 uM SER ILE ILE GLY PHE GLU LYS LEU n/a n/a
293 1VAC - SER ILE ILE ASN PHE GLU LYS LEU n/a n/a
294 3PWU - ILE PRO ALA TYR GLY VAL LEU THR ILE n/a n/a
295 3CC5 - LYS VAL PRO ARG ASN GLN ASP TRP LEU n/a n/a
296 5MZM - MET CYS PRO ARG MET THR ALA VAL MET n/a n/a
297 4L8B - ALA SER ASN GLU HIS MET GLU THR MET n/a n/a
298 3CPL - ALA SER ASN GLU ASN ALA GLU THR MET n/a n/a
299 1WBY - SER SER LEU GLU ASN PHE ARG ALA TYR VAL n/a n/a
300 3CH1 - GLU GLY PRO ARG ASN GLN ASP TRP LEU n/a n/a
301 4HV8 - ALA SER ASN GLU ASN ILE GLU THR MET n/a n/a
302 1WBX - SER GLN LEU LYS ASN ASN ALA LYS GLU ILE n/a n/a
303 1YN7 - SER SER LEU GLU ASN PHE ALA ALA TYR VAL n/a n/a
304 1YN6 - SER SER LEU GLU ASN PHE ARG ALA TYR VAL n/a n/a
305 1JUF ic50 = 1400 nM SER SER VAL ILE GLY VAL TRP TYR LEU n/a n/a
306 1JPG - PHE GLN PRO GLN ASN GLY GLN PHE ILE n/a n/a
307 5E8O - MET ABA LEU ARG MET THR ALA VAL MET n/a n/a
308 1LD9 - TYR PRO ASN VAL ASN ILE HIS ASN PHE n/a n/a
309 5E8P - MET CYS LEU ARG NLE THR ALA VAL MET n/a n/a
310 1HOC - ALA SER ASN GLU ASN MET GLU THR MET n/a n/a
311 4HUX - ALA SER ASN GLU ASN MET GLU THR MET n/a n/a
312 4HUV - ALA SER ASN GLU ASN TRP GLU THR MET n/a n/a
313 1INQ ic50 = 539 nM SER SER VAL VAL GLY VAL TRP TYR LEU n/a n/a
314 2ZOK - ABA SER LEU TRP ASN GLY PRO HIS LEU n/a n/a
315 5E8N - MET CYS LEU ARG MET THR ALA VAL MET n/a n/a
316 4HUU - ALA SER ASN GLU ASN ILE GLU THR MET n/a n/a
317 4L8D - ALA SER ASN GLU ASP MET GLU THR MET n/a n/a
318 1S7Q - LYS ALA VAL TYR ASN PHE ALA THR MET n/a n/a
319 1S7T - LYS ALA VAL PHE ASN PHE ALA THR MET n/a n/a
320 4G43 - ILE ASP TRP PHE GLU GLY LYS GLU n/a n/a
321 4E0R - ILE ASP TRP PHE ASP GLY LYS GLU n/a n/a
322 4G42 - ILE ASP TRP PHE ASP GLY LYS ASP n/a n/a
323 4ZFZ Kd = 2.5 uM GLY GLY ALA ILE SER MYR n/a n/a
324 4CVZ - TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU n/a n/a
325 3RWG ic50 = 2.8 nM MET HIS PRO ALA GLN THR SER GLN TRP n/a n/a
326 3RWI ic50 = 116 nM GLY SER HIS LEU GLU VAL GLN GLY TYR TRP n/a n/a
327 3RWC ic50 = 7.6 nM ILE ARG TYR PRO LYS THR PHE GLY TRP n/a n/a
328 3RWE ic50 = 43 nM PHE GLN TRP MET GLY TYR GLU LEU TRP n/a n/a
329 1BII - ARG GLY PRO GLY ARG ALA PHE VAL THR ILE n/a n/a
330 3FOM - ILE GLN GLN SER ILE GLU ARG ILE n/a n/a
331 3FON - VAL ASN ASP ILE PHE GLU ALA ILE n/a n/a
332 5GSV - PHE TYR ALA PRO GLU PRO ILE THR SER LEU n/a n/a
333 4WDI Kd = 286 uM LEU TYR LEU VAL CYS GLY GLU ARG GLY n/a n/a
334 5GSR - TYR TYR SER ILE ALA PRO HIS SER ILE n/a n/a
335 5GR7 - TYR TYR SER ILE ILE PRO HIS SER ILE n/a n/a
336 4Z78 Kd = 113 uM LEU TYR LEU VAL CYS GLY GLU ARG GLY PHE n/a n/a
337 4Z76 Kd = 13.6 uM LEU TYR LEU VAL CYS GLY GLU ARG VAL n/a n/a
338 5GSX - PHE TYR ALA PRO GLU PRO ILE THR SER LEU n/a n/a
339 5GSB - LYS TYR TYR SER ILE ILE PRO HIS SER ILE n/a n/a
340 3BZF - VAL MET ALA PRO ARG ALA LEU LEU LEU n/a n/a
341 6GH4 - ARG GLN PRO ALA LYS ALA PRO LEU LEU n/a n/a
342 6GH1 - ARG LEU PRO ALA LYS ALA PRO LEU LEU n/a n/a
343 3BZE - VAL MET ALA PRO ARG THR LEU PHE LEU n/a n/a
344 5H94 - LYS MET ASN THR GLN PHE THR ALA VAL n/a n/a
345 3QQ4 - ALA THR ALA ALA ALA THR GLU ALA TYR n/a n/a
346 5XS3 - VAL ARG SER ARG ARG CYS LEU ARG LEU n/a n/a
347 3ECB - ARG GLY PRO GLY ARG ALA PHE VAL THR ILE n/a n/a
348 5WEU Kd = 0.19 mM ARG GLY PRO GLY CYS ALA PHE VAL THR ILE n/a n/a
349 3E6F - ILE GLY PRO GLY ARG ALA PHE TYR ALA n/a n/a
350 5KD7 - ILE GLY PRO GLY ARG ALA PHE TYR VAL n/a n/a
351 3E6H - ILE GLY PRO GLY ARG ALA PHE TYR THR ILE n/a n/a
352 5T7G - ILE GLY PRO GLY ARG ALA PHE TYR THR n/a n/a
353 1MHC - FME TYR PHE ILE ASN ILE LEU THR LEU n/a n/a
354 1ZT1 - PHE GLU ALA ASN GLY ASN LEU ILE n/a n/a
355 1K8D - ILE LEU MET GLU HIS ILE HIS LYS LEU n/a n/a
356 1KJM - ALA GLN PHE SER ALA SER ALA SER ARG n/a n/a
357 5J6H - NCA C6 H6 N2 O c1cc(cnc1)....
358 1KJV - ASN PRO ARG ALA MET GLN ALA LEU LEU n/a n/a
359 1YDP - ARG ILE ILE PRO ARG HIS LEU GLN LEU n/a n/a
360 3KYN - LYS GLY PRO PRO ALA ALA LEU THR LEU n/a n/a
361 3KYO - LYS LEU PRO ALA GLN PHE TYR ILE LEU n/a n/a
362 1S7X - LYS ALA VAL PHE ASN PHE ALA THR MET n/a n/a
363 1S7U - LYS ALA VAL TYR ASN PHE ALA THR MET n/a n/a
364 1S7V - LYS ALA VAL TYR ASN LEU ALA THR MET n/a n/a
365 1S7W - LYS ALA LEU TYR ASN PHE ALA THR MET n/a n/a
366 1TMC - GLU VAL ALA PRO PRO GLU TYR HIS ARG LYS n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU; Similar ligands found: 248
No: Ligand ECFP6 Tc MDL keys Tc
1 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 1 1
2 ARG ARG ILE TYR ASP LEU ILE GLU LEU 0.684615 0.933333
3 PHE ARG TYR LEU GLY 0.672269 0.916667
4 SER LEU ARG PHE LEU TYR GLU GLY 0.643411 0.888889
5 GLU LEU ARG ARG LYS MET MET TYR MET 0.630769 0.888889
6 GLU GLU ASN LEU LEU ASP PHE VAL ARG PHE 0.62963 0.868852
7 SER ASP TYR GLN ARG LEU 0.628099 0.915254
8 SER GLU LEU GLU ILE LYS ARG TYR 0.62406 0.888889
9 SER SER ARG LYS GLU TYR TYR ALA 0.622951 0.932203
10 ALA ARG THR GLU LEU TYR ARG SER LEU 0.609023 0.903226
11 PHE TYR ARG ALA LEU MET 0.606061 0.857143
12 GLY GLY LYS LYS ARG TYR LYS LEU 0.603175 0.916667
13 GLY GLY ARG LYS LYS TYR LYS LEU 0.603175 0.916667
14 GLY GLY LYS LYS LYS TYR ARG LEU 0.603175 0.916667
15 SER SER LEU GLU ASN PHE ARG ALA TYR VAL 0.60274 0.904762
16 GLU ASN GLN LYS GLU TYR PHE PHE 0.58871 0.786885
17 ILE ARG LYS ILE LEU PHE LEU ASP GLY ILE 0.587413 0.822581
18 PHE LEU ARG GLY ARG ALA TYR GLY LEU 0.585185 0.933333
19 GLU LEU ASN ARG LYS MET ILE TYR MET 0.585034 0.848485
20 GLU LEU LYS TPO GLU ARG TYR 0.578571 0.850746
21 GLU LEU LYS ARG LYS MET ILE TYR MET 0.577465 0.859375
22 SER GLU ILE GLU PHE ALA ARG LEU 0.573529 0.793651
23 PHE LEU SER TYR LYS 0.572581 0.806452
24 GLU ILE ILE ASN PHE GLU LYS LEU 0.571429 0.725806
25 GLU LEU ASP LYS TYR ALA SER 0.569231 0.819672
26 SER ILE ILE ASN PHE GLU LYS LEU 0.567164 0.71875
27 LYS MET ASP SEP PHE LEU ASP MET GLN LEU 0.566434 0.666667
28 ILE LEU GLY LYS PHE LEU HIS ARG LEU 0.566434 0.776119
29 PHE LEU ARG GLY ARG ALA TYR VAL LEU 0.566434 0.933333
30 ASP ALA ASP GLU TYR LEU 0.565574 0.762712
31 ASN ALA LEU LEU ARG TYR LEU LEU ASP 0.564885 0.901639
32 TYR GLN SER LYS LEU 0.561983 0.790323
33 PHE LEU ALA TYR LYS 0.56 0.830508
34 GLU ASN PRO THR TYR LYS PHE PHE GLU GLN 0.555556 0.803279
35 THR TYR LYS PHE PHE GLU GLN 0.555556 0.803279
36 CYS THR GLU LEU LYS LEU ASN ASP TYR 0.554745 0.793651
37 LEU TYR LEU VAL CYS GLY GLU ARG GLY PHE 0.554054 0.887097
38 ASP ALA GLU PHE ARG HIS ASP 0.550388 0.79661
39 SER SER ILE GLU PHE ALA ARG LEU 0.55 0.809524
40 ARG PHE MET ASP TYR TRP GLU GLY LEU 0.54717 0.8
41 SER GLU ASP GLU PHE TYR ASP ALA LEU SER 0.543478 0.819672
42 VAL LYS VAL VAL ALA LYS LYS TYR ARG ASN 0.541985 0.901639
43 GLY ASN PHE LEU GLN SER ARG 0.540741 0.796875
44 CYS THR GLU LEU LYS LEU SER ASP TYR 0.539568 0.793651
45 GLU ASN LEU TYR PHE GLN 0.539062 0.770492
46 ILE LEU ALA LYS PHE LEU HIS GLU LEU 0.539007 0.712121
47 ASP PHE GLU ASP TYR GLU PHE ASP 0.536585 0.737705
48 GLN PHE LYS ASP ASN VAL ILE LEU LEU 0.535211 0.741935
49 ALA LYS PHE ARG HIS ASP 0.533333 0.769231
50 THR ASN GLU TYR LYS VAL 0.531746 0.786885
51 LEU ASP GLU GLU THR GLY GLU PHE LEU 0.529851 0.741935
52 LEU GLU LYS ALA ARG GLY SER THR TYR 0.526316 0.904762
53 GLU GLN TYR LYS PHE TYR SER VAL 0.525926 0.822581
54 GLU ARG GLU SEP GLU PHE ASP ILE GLU ASP 0.52349 0.724638
55 VAL LEU ARG ASP ASP LEU LEU GLU ALA 0.520325 0.813559
56 ARG GLY TYR LEU TYR GLN GLY LEU 0.518248 0.916667
57 ASP GLU LEU GLU ILE LYS ALA TYR 0.517986 0.833333
58 SER ILE ILE GLY PHE GLU LYS LEU 0.517986 0.703125
59 GLY GLY LYS LYS LYS TYR GLN LEU 0.515385 0.816667
60 GLY ASP GLU VAL LYS VAL PHE ARG 0.514085 0.833333
61 GLU GLU TYR LEU GLN ALA PHE THR TYR 0.514085 0.770492
62 GLU ASP GLU ASP PHE GLU ILE LEU SEP LEU 0.513514 0.623188
63 LEU TYR LEU VAL CYS GLY GLU ARG VAL 0.513514 0.854839
64 THR ASN GLU PHE TYR PHE 0.512397 0.688525
65 ARG ARG LEU LEU ARG GLY HIS ASN GLN TYR 0.509934 0.850746
66 PRO LEU GLU PSA ARG LEU 0.506849 0.80303
67 THR GLU ASN LEU TYR PHE GLN SER GLY THR 0.506849 0.796875
68 GLU GLU TYR LEU LYS ALA TRP THR PHE 0.50625 0.776119
69 ASN PHE ASP ASN PRO VAL TYR ARG LYS THR 0.506024 0.794521
70 ALA ARG LYS LEU ASP 0.504202 0.813559
71 ASP ALA GLU PHE ARG HIS ASP SER 0.503497 0.753846
72 SER SER LEU GLU ASN PHE ALA ALA TYR VAL 0.503448 0.777778
73 LEU GLU LEU ASP LYS TRP ALA SER LEU 0.503356 0.705882
74 LEU TYR LEU VAL CYS GLY GLU ARG GLY 0.5 0.854839
75 GLY GLY LYS LYS LYS TYR LYS LEU 0.5 0.816667
76 GLU ASP GLU ASP PHE GLU ILE LEU SER LEU 0.496504 0.714286
77 ALA ALA SER LEU TYR GLU LYS LYS ALA ALA 0.49635 0.806452
78 GLU GLU PHE GLY ARG ALA PHE SER PHE 0.493056 0.777778
79 PHE ARG SER LYS GLY GLU GLU LEU PHE THR 0.492188 0.746032
80 ACE GLU ASN LEU TYR PHE GLN SER GLY THR 0.489051 0.758065
81 TYR ASP GLN ILE LEU 0.488189 0.733333
82 ARG HIS ARG MLY VAL LEU ARG ASP TYR 0.487179 0.805556
83 ALA GLN ASP ILE TYR ARG ALA SER TYR 0.486842 0.888889
84 ACE PHE LYS PHE TA2 ALA LEU ARG NH2 0.486301 0.84127
85 THR ASN GLU PHE TYR ALA 0.484615 0.725806
86 HIS SER LYS LYS LYS CYS ASP GLU LEU 0.482269 0.695652
87 THR LYS ASN TYR LYS GLN PHE SER VAL 0.482014 0.809524
88 ARG HIS ARG MLZ VAL LEU ARG ASP ASN TYR 0.481481 0.828571
89 LYS VAL LEU PHE LEU ASP GLY 0.481203 0.733333
90 PHE GLU ALA ILE PRO ALA GLU TYR LEU 0.480519 0.690141
91 TYR GLY GLY PHE LEU 0.480315 0.8
92 ILE LEU ALA LYS PHE LEU HIS ARG LEU 0.480263 0.742424
93 SER ARG LYS ILE ASP ASN LEU ASP 0.478873 0.796875
94 SER GLN TYR TYR TYR ASN SER LEU 0.476923 0.777778
95 GLY ALA ALA ARG ALA GLU VAL TYR LEU ARG 0.473684 0.916667
96 ARG ARG LEU ILE PHE NH2 0.473282 0.766667
97 LEU LEU GLU LEU ASP LYS TRP ALA NH2 0.472222 0.707692
98 LYS ILE LEU HIS ARG LEU LEU GLN ASP SER 0.471698 0.764706
99 HIS LYS ILE LEU HIS ARG LEU LEU GLN GLU 0.471338 0.772727
100 GLU THR VAL ARG PHE GLN SER ASP 0.469388 0.806452
101 THR PRO ASP TYR PHE LEU 0.469231 0.796875
102 LYS ALA LEU TYR ASN PHE ALA THR MET 0.467105 0.787879
103 ARG ARG LYS TRP ARG ARG TRP HIS LEU 0.466667 0.80303
104 GLU LEU ARG SER ARG TYR TRP ALA ILE 0.466258 0.84058
105 TYR GLN PHE 0.466102 0.694915
106 THR PHE GLN ALA PSA LEU ARG GLU 0.464968 0.887097
107 GLY ARG PHE ALA ALA ALA ILE ALA LYS 0.464789 0.803279
108 ASP LEU TYR CYS TYR GLU GLN LEU ASN 0.464286 0.806452
109 GLY ILE LEU GLU PHE VAL PHE THR LEU 0.464286 0.741935
110 PHE GLN TRP MET GLY TYR GLU LEU TRP 0.462963 0.714286
111 ARG VAL LEU PHE GLU ALA MET 0.462585 0.793651
112 ARG PRO GLY ASN PHE LEU GLN ASN ARG PRO 0.461538 0.758065
113 ARG MET PHE PRO ASN ALA PRO TYR LEU 0.461078 0.766234
114 ALA ARG LYS ILE ASP ASN LEU ASP 0.460993 0.806452
115 ASP ASP LEU TYR GLY 0.459677 0.783333
116 GLY VAL TYR ASP GLY ARG GLU HIS THR VAL 0.459627 0.823529
117 LYS VAL ILE THR PHE ILE ASP LEU 0.457746 0.758065
118 HIS LYS ILE LEU HIS ARG LEU LEU GLN ASP 0.457516 0.742424
119 VAL LEU CIR ASP ASP LEU LEU GLU ALA 0.456693 0.75
120 ILE ASP TRP PHE GLU GLY LYS GLU 0.455128 0.701493
121 ILE ASP TRP PHE ASP GLY LYS GLU 0.455128 0.701493
122 ARG ARG LYS TRP CIR ARG TRP HIS LEU 0.454545 0.791045
123 ARG ASP ARG ALA ALA LYS LEU 0.451613 0.779661
124 PHE GLU ALA ASN GLY ASN LEU ILE 0.451389 0.698413
125 THR ARG ARG GLU THR GLN LEU 0.450382 0.819672
126 SER VAL TYR ASP PHE PHE VAL TRP LEU 0.450331 0.705882
127 ARG VAL ALA GLN LEU GLU GLN VAL TYR ILE 0.450331 0.883333
128 TYR GLN GLU SER THR ASP PHE THR PHE LEU 0.448819 0.688525
129 ILE LEU ALA LYS PHE LEU HIS THR LEU 0.447368 0.720588
130 TYR PRO LYS ARG ILE ALA 0.447368 0.746479
131 ALA GLN PHE SER ALA SER ALA SER ARG 0.445255 0.790323
132 ALA ASN SER ARG TRP GLN ASP THR ARG LEU 0.444444 0.797101
133 PHQ LEU VAL ARG TYR 0.443662 0.887097
134 ASP ASN ARG LEU GLY LEU VAL TYR GLN PHE 0.443609 0.762712
135 PAC DLY DLY DAR 0.443548 0.766667
136 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.443182 0.72973
137 ALA ILE MET PRO ALA ARG PHE TYR PRO LYS 0.443182 0.746667
138 LEU GLU PHE GLN GLY 0.44186 0.7
139 LYS GLN TRP ASP ASN TYR GLU PHE ILE TRP 0.440994 0.691176
140 THR ASN GLU PHE ALA PHE 0.440945 0.622951
141 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.440252 0.702703
142 SER HIS PHE ASN GLU TYR GLU 0.44 0.705882
143 LEU PRO PHE ASP ARG THR THR ILE MET 0.439759 0.701299
144 ASP GLU ASP LYS TRP ASP ASP PHE 0.439716 0.676923
145 ACE ILE TYR GLU SER LEU 0.439394 0.714286
146 ARG GLY TYR VAL TYR GLN GLY LEU 0.439189 0.916667
147 GLY ASN TYR SER PHE TYR ALA LEU 0.437956 0.75
148 ARG LEU GLN ARG ARG ARG GLU THR GLN VAL 0.437956 0.819672
149 GLU ALA GLN THR ARG LEU 0.437956 0.786885
150 GLY ALA GLU VAL PHE TYR VAL ASP GLY ALA 0.4375 0.786885
151 ARG HIS LYS ALY LEU MET PHE LYS 0.436709 0.7
152 THR ASN GLU TYR TYR VAL 0.436508 0.737705
153 SER TRP PHE GLN THR ASP LEU 0.435065 0.691176
154 ASN LYS ASP LYS GLU TYR TYR VAL ANS 0.434783 0.602273
155 GLN VAL ASN PHE LEU GLY LYS 0.434483 0.725806
156 GLY HIS LYS ILE LEU HIS ARG LEU LEU GLN 0.434211 0.761194
157 GLU VAL ALA PRO PRO GLU TYR HIS ARG LYS 0.434066 0.767123
158 PRO VAL LYS ARG ARG LEU ASP LEU GLU 0.433333 0.78125
159 ASP SEP TYR GLU VAL LEU ASP LEU 0.431373 0.691176
160 LYS PRO ILE VAL GLN TYR ASP ASN PHE 0.431138 0.726027
161 GLU LEU ASP LYS TRP ALA SER 0.430464 0.716418
162 SER LEU LYS ILE ASP ASN GLU ASP 0.429577 0.6875
163 PTR LEU ARG VAL ALA 0.428571 0.787879
164 ASP PHE GLU GLU ILE 0.428571 0.65
165 ASN GLN LEU ALA TRP PHE ASP THR ASP LEU 0.428571 0.671642
166 GLU LEU ASP 1OL VAL GLU PHE 0.428571 0.728814
167 GLU LEU ASP LYS TRP ALA ASN 0.427632 0.701493
168 LEU GLY GLY ALA LYS GLN ARG GLY ASP VAL 0.427536 0.783333
169 CYS THR PHE LYS THR LYS THR ASN 0.426471 0.730159
170 TYR MET PHE PRO ASN ALA PRO TYR LEU 0.425926 0.675325
171 THR LYS ASN TYR LYS GLN THR SER VAL 0.425676 0.793651
172 SER GLN LEU LYS ASN ASN ALA LYS GLU ILE 0.425532 0.703125
173 ALA LEU ASP LYS TRP ASP 0.425532 0.723077
174 GLU GLY PRO ARG ASN GLN ASP TRP LEU 0.425287 0.72973
175 GLY TYR GLU ASN PRO THR TYR LYS PHE PHE 0.42515 0.684932
176 ALA PHE ARG ILE PRO LEU THR ARG 0.425 0.726027
177 ARG TYR GLY PHE VAL ALA ASN PHE 0.424837 0.887097
178 PRO GLU GLY ASP PM3 GLU GLU VAL LEU 0.424658 0.681818
179 VAL ARG SER ARG ARG ABA LEU ARG LEU 0.424242 0.761905
180 TYR LEU LYS GLU PRO VAL HIS GLY VAL 0.423529 0.708333
181 ACE GLN LEU ASP ALA PHE 0.423077 0.65
182 ILE ASP TRP PHE ASP GLY LYS ASP 0.423077 0.701493
183 ARG PRO MET THR PHE LYS GLY ALA LEU 0.422857 0.688312
184 GLY ALA GLU THR PHE TYR VAL ASP GLY ALA 0.422819 0.777778
185 LEU PRO PHE GLU ARG ALA THR ILE MET 0.421965 0.688312
186 ARG PRO GLY ASN PHE LEU GLN SER ARG LEU 0.421965 0.702703
187 LEU LEU TYR GLY PHE VAL ASN TYR VAL 0.421769 0.774194
188 VAL MET ALA PRO ARG THR LEU PHE LEU 0.421687 0.675325
189 THR PHE LYS LYS THR ASN 0.421053 0.741935
190 ARG PRO MET THR TYR LYS GLY ALA LEU 0.420455 0.727273
191 ACE ARG ARG LEU ASN FCL NH2 0.42029 0.742424
192 GLU LEU ASP LYS TRP ALA GLY 0.42 0.69697
193 LEU LEU TYR GLY PHE VAL ASN TYR ILE 0.42 0.761905
194 ACE PHE LYS PHE PSA LEU AAR 0.418919 0.857143
195 ARG PRO PRO ILE PHE ILE ARG ARG LEU 0.41875 0.71831
196 LEU PRO PHE GLU ARG ALA THR VAL MET 0.418605 0.697368
197 LYS ARG TRP ILE ILE LEU GLY LEU ASN LYS 0.417647 0.768116
198 ARG ARG PHE AIB ALA MET LEU ALA 0.417219 0.753846
199 LYS LEU PRO ALA GLN PHE TYR ILE LEU 0.416667 0.71831
200 ACE ALA ARG THR GLU VAL TYR NH2 0.416667 0.868852
201 GLU THR PHE TYR VAL ASP GLY 0.415493 0.790323
202 VAL ALA PHE ARG SER 0.414815 0.754098
203 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.414365 0.662162
204 TYR GLN PHE GLY PRO ASP PHE PRO ILE ALA 0.414201 0.732394
205 BP4 CYS DAR TYR PEA 0.413793 0.793651
206 ARG ARG ARG TRP HIS ARG TRP ARG LEU 0.413333 0.787879
207 ARG THR PHE SER PRO THR TYR GLY LEU 0.413174 0.794521
208 SER ARG TYR TRP ALA ILE ARG THR ARG 0.413174 0.811594
209 ALA PRO ALA LEU ARG VAL VAL LYS 0.412214 0.779661
210 LEU TYR ALA SER PRO GLN LEU GLU GLY PHE 0.411765 0.708333
211 HIS GLU GLU LEU ALA LYS LEU 0.41129 0.677966
212 VAL ASN ASP ILE PHE GLU ALA ILE 0.410959 0.66129
213 ALA ARG THR MLY GLN THR ALA ARG TYR 0.410596 0.838235
214 GLU LEU GLU LYS TRP ALA SER 0.410596 0.701493
215 ACE GLU ALA GLN THR ARG LEU 0.410072 0.774194
216 PHE PRO THR LYS ASP VAL ALA LEU 0.409938 0.666667
217 LEU PRO PHE ASP LYS THR THR ILE MET 0.409639 0.623377
218 VAL ARG SER ARG ARG CYS LEU ARG LEU 0.409091 0.761905
219 ACE PHE ASP GLU MET GLU GLU CYS 0.409091 0.640625
220 GLU GLN ASP LYS TRP ALA SER 0.409091 0.686567
221 ACE GLN ALA ASP LEU PHE 0.409091 0.65
222 GLY ARG PHE GLN VAL THR 0.408451 0.786885
223 LEU LYS THR LYS LEU LEU 0.408 0.704918
224 ARG ARG ARG TRP ARG ARG LEU THR VAL 0.407895 0.80597
225 LYS ALA VAL TYR ASN PHE ALA THR MET 0.407643 0.787879
226 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.407407 0.76
227 ILE GLY PRO GLY ARG ALA PHE TYR ALA 0.407186 0.774648
228 ALA THR ARG ASN PHE SER GLY 0.406897 0.765625
229 GLU LEU ASP ORN TRP ALA SER 0.405229 0.701493
230 ILE LEU MET GLU HIS ILE HIS LYS LEU 0.405229 0.657143
231 ARG HIS ARG MLY VAL LEU ARG ASP ASN 0.405063 0.712329
232 LYS TYR LYS 0.404959 0.745763
233 GLU LEU ASP NRG TRP ALA SER 0.404908 0.688312
234 ALA THR VAL ARG THR TYR SER CYS 0.40411 0.84127
235 SER ILE TYR PHE TPO PRO GLU LEU TYR ASP 0.403409 0.6625
236 PRO GLU SEP LEU GLU SER CYS PHE 0.402778 0.628571
237 DTY ILE ARG LEU LPD 0.402685 0.732394
238 GLU ALA ASP LYS TRP GLN SER 0.402597 0.686567
239 PCA PHE ARG HIS ASP SER GLY TYR GLU VAL 0.402516 0.735294
240 LYS GLN GLU PRO GLN GLU ILE ASP PHE 0.402439 0.619718
241 SER PHE PHE GLU ASP ASN PHE VAL PRO GLU 0.401316 0.648649
242 LYS ALA VAL TYR ASN LEU ALA THR MET 0.401274 0.757576
243 TYR HIS SEP VAL VAL ARG TYR ALA 0.401235 0.743243
244 LEU PRO PHE ASP LYS SER THR ILE MET 0.401163 0.615385
245 GLN VAL PRO LEU ARG PRO MET THR TYR LYS 0.401099 0.75
246 ALA LEU ASP LYS TRP ALA SER 0.4 0.716418
247 GLY ALA ASP ILE PHE TYR LEU ASP GLY ALA 0.4 0.754098
248 FME TYR PHE ILE ASN ILE LEU THR LEU 0.4 0.716418
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4CVZ; Ligand: TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU; Similar sites found with APoc: 269
This union binding pocket(no: 1) in the query (biounit: 4cvz.bio1) has 36 residues
No: Leader PDB Ligand Sequence Similarity
1 4V2O CLQ None
2 4WG0 CHD None
3 1SLT NDG GAL 1.49254
4 4ZSI GLP 1.75439
5 4ZSI 4R1 1.75439
6 6AP8 BNY 1.85874
7 1NU4 MLA 2.06186
8 5NBP BGC BGC BGC 2.20588
9 1WMA AB3 2.53623
10 4YLZ LAT NAG GAL 2.61438
11 5B09 4MX 2.88462
12 3AGC RCC 2.89855
13 1YYE 196 2.98507
14 3CBC DBS 3.0303
15 3AJH BL3 3.22581
16 2YJD YJD 3.33333
17 4J26 EST 3.33333
18 4J24 EST 3.33333
19 1UI0 URA 3.41463
20 3GF2 SAL 3.42466
21 5EO8 TFU 3.53698
22 5ODY 9SK 3.62319
23 3W54 RNB 3.64742
24 1I0B PEL 3.64742
25 3O01 DXC 3.8961
26 5OKL PAM 4.08163
27 6BYM HC3 4.08163
28 4OAS 2SW 4.16667
29 3GFZ FMN 4.25532
30 6E08 NAP 4.25532
31 5MBC FMN 4.25532
32 5N8V KZZ 4.34783
33 5M37 9SZ 4.34783
34 2P7Q GG6 4.51128
35 2HZQ STR 4.5977
36 3F8C HT1 4.7619
37 6B21 C9V 4.86322
38 5MWE TCE 4.93827
39 4DE3 DN8 4.94297
40 2WOR 2AN 5
41 1NF8 BOG 5.10204
42 3QRC SCR 5.10204
43 5V4R MGT 5.10204
44 2CDO GAL AAL GAL AAL GAL AAL 5.10204
45 3BGD PM6 5.10204
46 4G86 BNT 5.10204
47 5F74 AMP 5.10204
48 3B6C SDN 5.10204
49 2CIX CEJ 5.10204
50 1YC4 43P 5.10204
51 5AYE BMA BMA 5.10204
52 4DK7 0KS 5.10204
53 2RH1 CLR 5.16717
54 3NJQ NJQ 5.18135
55 6BR9 PGV 5.47112
56 1YRX FMN 5.78512
57 4V1F BQ1 5.81395
58 5OLK DTP 6.07903
59 4ZU4 4TG 6.08108
60 2BCG GER 6.12245
61 5W7B MYR 6.12245
62 5H9Q TD2 6.12245
63 5V3Y 5V8 6.12245
64 3KFF XBT 6.12245
65 3KFF ZBT 6.12245
66 4W9N TCL 6.12245
67 4TV1 36M 6.12245
68 3WYJ H78 6.12245
69 4H6B 10Y 6.12245
70 6BMS PLM 6.12245
71 4H6B 10X 6.12245
72 1W96 S1A 6.12245
73 4MGD 27N 6.12245
74 4TUZ 36J 6.12245
75 4MG8 27J 6.12245
76 1QY1 PRZ 6.12245
77 3O94 NCA 6.12245
78 4MG7 27H 6.12245
79 4OAR 2S0 6.12245
80 2BJ4 OHT 6.12245
81 5HYR EST 6.12245
82 4DXJ 0M9 6.12245
83 3GUZ PAF 6.25
84 3SAO NKN 6.25
85 5C1M OLC 6.4
86 5C1M CLR 6.4
87 2GBB CIT 6.41026
88 4JGP PYR 6.45161
89 1XMY ROL 6.68693
90 1XM4 PIL 6.68693
91 1R89 CTP 6.68693
92 3HP9 CF1 6.68693
93 1XMU ROF 6.68693
94 4UCC ZKW 6.86695
95 5JSP DQY 6.96517
96 6BR8 6OU 7.14286
97 2GWH PCI 7.14286
98 5GLT BGC GAL NAG GAL 7.14286
99 4JHG ZEA 7.14286
100 1TV5 N8E 7.14286
101 6BR8 PGV 7.14286
102 5TVM PUT 7.14286
103 3E70 GDP 7.14286
104 5O9W AKG 7.14286
105 1P0Z FLC 7.14286
106 3G58 988 7.14286
107 4P42 PEE 7.14286
108 2Z77 HE7 7.19424
109 3KP6 SAL 7.28477
110 2BHW NEX 7.32759
111 2BHW XAT 7.32759
112 1ZPD CIT 7.59878
113 1ZM1 BGC BGC BGC 7.88382
114 4F4S EFO 7.89474
115 5M36 9SZ 7.89474
116 6GN6 GLC 7.90274
117 5CHR 4NC 8.0292
118 1N8V BDD 8.03571
119 6GNO XDI 8.14815
120 3TDC 0EU 8.16327
121 1R6N 434 8.16327
122 1UBY DMA 8.16327
123 3ZGJ RMN 8.16327
124 5MZI FYK 8.16327
125 3B99 U51 8.16327
126 3FUR Z12 8.16327
127 1GNI OLA 8.16327
128 3G9E RO7 8.16327
129 3T03 3T0 8.16327
130 3ET3 ET1 8.16327
131 1JAY F42 8.16327
132 2OZ5 7XY 8.16327
133 2HFP NSI 8.16327
134 4IAW LIZ 8.16327
135 2P4Y C03 8.16327
136 2PRG BRL 8.16327
137 5L7G LYS SER LEU LEU GLN GLN LEU LEU THR GLU 8.20669
138 6CED EYA 8.41121
139 4I90 CHT 8.58086
140 4WGF HX2 8.78049
141 6EVN PRO PRO GLY PRO ALA GLY PRO PRO GLY 8.82353
142 4QVX 3CQ 8.98204
143 1MAI I3P 9.16031
144 3N7S 3N7 9.18367
145 4URN NOV 9.18367
146 4O4Z N2O 9.18367
147 5IM3 DTP 9.18367
148 5NM7 GLY 9.18367
149 1XZ3 ICF 9.18367
150 2JFN UMA 9.18367
151 3JRX S1A 9.18367
152 5W3Y IHP 9.18367
153 3PQB VGP 9.18367
154 2VAT COA 9.18367
155 4LIT AKG 9.18367
156 4A59 AMP 9.42249
157 1M2Z BOG 9.72763
158 2VWA PTY 9.90099
159 3WG3 A2G GAL NAG FUC 10.1124
160 4BTB PRO PRO PRO PRO PRO PRO PRO PRO PRO 10.2041
161 6MVU K4V 10.2041
162 5TZO 7V7 10.2041
163 2HZL PYR 10.2041
164 2JHP GUN 10.2041
165 5OSW DIU 10.2041
166 4HK8 XYP XYP XYP XYP XYP XYP 10.2041
167 3WDX BGC BGC GLC 10.2041
168 1KGI T4A 10.2362
169 4WQ2 3SU 10.4046
170 3RLB VIB 10.4167
171 5O2Z FLC 10.9244
172 1ZB6 DIN 11.0749
173 3OKI OKI 11.1588
174 1NYW DAU 11.1675
175 1A78 TDG 11.194
176 6CB2 OLC 11.2245
177 3A76 SPD 11.2245
178 2O1V ADP 11.2245
179 1J78 VDY 11.2245
180 5VGS 9A4 11.2245
181 4DOO DAO 11.2245
182 5B4B LP5 11.2245
183 5ICK FEZ 11.3537
184 3STK PLM 11.3636
185 4P7U 1PS 11.6071
186 4MJ0 BGC SIA SIA GAL 11.6364
187 4NTX AMR 11.6667
188 1DTL BEP 12.2449
189 5U97 PIT 12.2449
190 1HK8 DGT 12.2449
191 1U0A BGC BGC BGC BGC 12.2449
192 5JOG 6LT 12.8405
193 5AZC PGT 13
194 3EYK EYK 13.2653
195 5IUY BOG 13.2653
196 5VRH OLB 13.2653
197 4YSX E23 13.2653
198 3VSV XYP 13.2653
199 2XN5 FUN 13.2653
200 5C8W PCG 13.2867
201 6DIO CIT 13.3739
202 4XCB AKG 13.41
203 3TL1 JRO 13.8365
204 3FAL REA 14.0496
205 2PEH LYS ARG LYS SER ARG TRP ASP GLU THR PRO 14.2857
206 3X01 AMP 14.2857
207 5OMY 9YE 14.2857
208 2OVW CBI 14.2857
209 1DKF OLA 14.5923
210 2BYC FMN 14.5985
211 5UNJ RJW 14.6939
212 3H0A D30 14.9123
213 5XJ7 87O 14.9254
214 5K52 OCD 15.0943
215 4U0W 16G 15.1976
216 2HHP FLC 15.3061
217 2PNC CLU 15.3061
218 3WV6 GAL BGC 15.3061
219 6CHP F0Y 15.3061
220 2ZHL NAG GAL GAL NAG 15.3061
221 3MG9 GHP 3MY 3FG GHP GHP OMY 3FG 15.3061
222 4RLT FSE 15.6463
223 2HJ3 FAD 16
224 6GR0 F8W 16.3265
225 4XPQ FUL 16.3265
226 5ZZA LAB 16.3265
227 3RMK BML 16.3265
228 4RC8 STE 17.3469
229 4M51 BEZ 17.3469
230 2Z7I 742 17.3469
231 4OGQ 1O2 17.6471
232 4OGQ 2WD 17.6471
233 4OGQ UMQ 17.6471
234 4OGQ 7PH 17.6471
235 4OGQ SQD 17.6471
236 5LX9 OLB 18.3673
237 5LWY OLB 18.3673
238 5K53 STE 18.3673
239 4ZGM 32M 19.3548
240 5UC4 83S 19.3878
241 3RGA LSB 19.4529
242 2YVE MBT 20
243 3HYW DCQ 20.4082
244 1HBK MYR 21.3483
245 5Y02 HBX 21.4953
246 6GMN F4E 21.6495
247 3OYW TDG 22.3881
248 1XVB 3BR 22.449
249 4I67 G G G RPC 22.9885
250 2Y69 CHD 23.2558
251 4IBF 1D5 23.4694
252 5Z84 CHD 23.5294
253 5ZCO CHD 23.5294
254 5W97 CHD 23.5294
255 2DYS PGV 23.5294
256 5ZCO PEK 23.5294
257 5Z84 PEK 23.5294
258 2DYR PGV 23.5294
259 1SQK LAR 24
260 1GEG GLC 24.4898
261 3ET1 ET1 24.4898
262 1X0P FAD 27.2727
263 5HWV MBN 27.551
264 6FS0 E4W 28.5714
265 1ZED PNP 31.6327
266 5OCA 9QZ 32.6531
267 5GQX GLC GLC GLC GLC 32.6531
268 1OFL NGK GCD 34.6939
269 3KPE TM3 41.0256
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