Receptor
PDB id Resolution Class Description Source Keywords
4CCK 2.15 Å EC: 1.14.11.27 60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66) IN COM WITH MN(II) AND N-OXALYLGLYCINE (NOG) HOMO SAPIENS OXIDOREDUCTASE NON-HEME IRON-BINDING DSBH 2-OXOGLUTARATEDIOXYGENASE JMJC DOMAIN RIBOSOME BIOGENESIS NUCLEAR PROTRPL8 BETA-HYDROXYLATION TRANSCRIPTION AND EPIGENETIC REGUSIGNALING
Ref.: RIBOSOMAL OXYGENASES ARE STRUCTURALLY CONSERVED FRO PROKARYOTES TO HUMANS. NATURE V. 510 422 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
OGA B:902;
D:902;
C:902;
A:902;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
147.086 C4 H5 N O5 C(C(=...
MN D:901;
C:901;
B:901;
A:901;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
submit data
54.938 Mn [Mn+2...
EDO B:903;
A:903;
D:903;
C:903;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4CCK 2.15 Å EC: 1.14.11.27 60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66) IN COM WITH MN(II) AND N-OXALYLGLYCINE (NOG) HOMO SAPIENS OXIDOREDUCTASE NON-HEME IRON-BINDING DSBH 2-OXOGLUTARATEDIOXYGENASE JMJC DOMAIN RIBOSOME BIOGENESIS NUCLEAR PROTRPL8 BETA-HYDROXYLATION TRANSCRIPTION AND EPIGENETIC REGUSIGNALING
Ref.: RIBOSOMAL OXYGENASES ARE STRUCTURALLY CONSERVED FRO PROKARYOTES TO HUMANS. NATURE V. 510 422 2014
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 13 families.
1 4CCK - OGA C4 H5 N O5 C(C(=O)O)N....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 11 families.
1 4CCK - OGA C4 H5 N O5 C(C(=O)O)N....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 4CCK - OGA C4 H5 N O5 C(C(=O)O)N....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: OGA; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 OGA 1 1
2 AAC 0.461538 0.827586
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4CCK; Ligand: OGA; Similar sites found: 83
This union binding pocket(no: 1) in the query (biounit: 4cck.bio1) has 12 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2QZT PLM 0.01648 0.42099 None
2 4IJP 1EH 0.01729 0.4077 1.39665
3 5UIU 8CG 0.0359 0.40389 1.85759
4 5LUN OGA 0.0004768 0.44586 1.98864
5 2ZI8 SDT 0.01464 0.40444 2
6 3NNF AKG 0.0001879 0.48623 2.03488
7 1GP6 QUE 0.00533 0.44227 2.24719
8 1GP6 SIN 0.004998 0.44227 2.24719
9 3AVS OGA 0.000008829 0.56374 2.78373
10 3AVR OGA 0.000008868 0.53463 2.78373
11 1OIK AKG 0.0001563 0.48803 2.99003
12 1OIJ AKG 0.0001072 0.4779 2.99003
13 1OIK C26 0.0003083 0.413 2.99003
14 5FWJ MMK 0.00002521 0.4875 2.99786
15 4UF0 MMK 0.000965 0.46509 2.99786
16 2JBM SRT 0.005033 0.41004 3.01003
17 5EPA AKG 0.001217 0.4274 3.22581
18 5UQD AKG 0.003307 0.41848 3.39367
19 4RFR RHN 0.000001911 0.45614 3.44828
20 2OG7 SIN 0.0002458 0.47344 3.64026
21 1NX4 AKG 0.0003935 0.46842 3.663
22 1GQG DCD 0.004541 0.44321 3.71429
23 3KRU FMN 0.01524 0.4267 3.79009
24 5C3R HMU 0.000604 0.40655 3.79009
25 5C3R AKG 0.000604 0.40655 3.79009
26 4XCB AKG 0.002256 0.41624 3.83142
27 1OS7 TAU 0.00001015 0.43176 3.88693
28 1OS7 AKG 0.00001015 0.43176 3.88693
29 2IXC TRH 0.0125 0.42397 3.9604
30 1R6W 164 0.003997 0.44008 4.03727
31 2C4I BTN 0.008787 0.42232 4.05904
32 1FEC FAD 0.01874 0.43738 4.06852
33 5HV0 AKG 0.00003333 0.54096 4.14747
34 4M26 AKG 0.0007672 0.44498 4.3956
35 4YRD 3IT 0.006552 0.40367 4.45682
36 5TFZ 7BC 0.00178 0.41151 4.66667
37 4J25 OGA 0.00003022 0.51091 4.80349
38 3H9A PPY 0.001151 0.45236 4.93827
39 4Q0L V14 0.01924 0.41329 5.32319
40 4ER2 IVA VAL VAL STA ALA STA 0.04401 0.40973 5.45455
41 5C5T AKG 0.000264 0.44711 5.70175
42 1J3R 6PG 0.004359 0.43156 5.78947
43 2IUW AKG 0.0000117 0.50238 5.88235
44 4XAC AKG 0.001352 0.43339 5.95238
45 3H7J PPY 0.0003449 0.41915 6.17284
46 2FCU AKG 0.0009566 0.44202 6.38978
47 4NPL AKG 0.000169 0.49034 6.4
48 2CWH NDP 0.02632 0.41404 6.41399
49 2OFV 242 0.04943 0.40461 6.4982
50 4P7X AKG 0.0003041 0.49466 6.50685
51 4P7X YCP 0.0003041 0.40907 6.50685
52 3SCH TB6 0.0009341 0.45001 6.56566
53 1ZZ7 S0H 0.004019 0.40493 6.56566
54 5FP3 3JI 0.00002492 0.40771 6.63812
55 2GOO NDG 0.006445 0.42764 7.01754
56 1QVJ RP5 0.00429 0.4118 7.19178
57 2ARC ARA 0.001576 0.41309 7.31707
58 2ET1 GLV 0.001565 0.43116 7.46269
59 3AMN CBK 0.0285 0.4064 7.54717
60 4IGQ OGA 0.0000004206 0.56644 8.05556
61 4IGQ THR M3L GLN 0.00001885 0.56644 8.05556
62 1SGJ OAA 0.01143 0.40198 9.50704
63 5KR7 6X9 0.0002065 0.43185 9.53679
64 3QRC SCR 0.01016 0.40511 9.55414
65 4LIT AKG 0.0000001008 0.65397 9.58231
66 5M0T AKG 0.00344 0.42486 9.86395
67 4OCT AKG 0.0002991 0.437 10.3604
68 2JIG PD2 0.00002185 0.54146 10.7143
69 5LY2 OGA 0.0001454 0.48996 11.5486
70 5FWE OGA 0.0002068 0.47974 11.5486
71 1DMY AZM 0.007887 0.41502 11.6935
72 3O94 NCA 0.008382 0.40555 11.8483
73 2Q8C AKG 0.0001712 0.48556 12.5
74 2Q8E OGA 0.0002361 0.4687 12.5
75 2P5B OGA 0.0005801 0.41832 12.5
76 1DRY AAG 0.001021 0.48236 14.5062
77 2Y0I AKG 0.00004097 0.50484 16.4773
78 1H2M OGA 0.00002052 0.53558 16.6189
79 1H2K OGA 0.00002341 0.53244 16.6189
80 2XUM OGA 0.00002622 0.52921 16.6189
81 3P3N AKG 0.00003145 0.52545 16.6189
82 4B7E OGA 0.00003892 0.50562 16.6189
83 2WA4 069 0.00001288 0.47455 16.6189
Pocket No.: 2; Query (leader) PDB : 4CCK; Ligand: OGA; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 4cck.bio1) has 11 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 4CCK; Ligand: OGA; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 4cck.bio1) has 11 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 4CCK; Ligand: OGA; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 4cck.bio1) has 11 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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