Receptor
PDB id Resolution Class Description Source Keywords
4BXF 2.05 Å EC: 1.14.11.- 60S RIBOSOMAL PROTEIN L27A HISTIDINE HYDROXYLASE (MINA53 Y20 COMPLEX WITH MN(II), 2-OXOGLUTARATE (2OG) AND 60S RIBOSOMALL 27A (RPL27A G37C) PEPTIDE FRAGMENT HOMO SAPIENS OXIDOREDUCTASE-TRANSLATION COMPLEX OXIDOREDUCTASE NON-HEMEIRON-BINDING DSBH DIOXYGENASE JMJC DOMAIN RIBOSOME BIOGNUCLEAR PROTEIN BETA-HYDROXYLATION TRANSCRIPTION AND EPIGREGULATION SIGNALING
Ref.: RIBOSOMAL OXYGENASES ARE STRUCTURALLY CONSERVED FRO PROKARYOTES TO HUMANS. NATURE V. 510 422 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
AKG B:901;
A:901;
Valid;
Valid;
none;
none;
submit data
146.098 C5 H6 O5 C(CC(...
MN A:601;
B:601;
Part of Protein;
Part of Protein;
none;
none;
submit data
54.938 Mn [Mn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4BXF 2.05 Å EC: 1.14.11.- 60S RIBOSOMAL PROTEIN L27A HISTIDINE HYDROXYLASE (MINA53 Y20 COMPLEX WITH MN(II), 2-OXOGLUTARATE (2OG) AND 60S RIBOSOMALL 27A (RPL27A G37C) PEPTIDE FRAGMENT HOMO SAPIENS OXIDOREDUCTASE-TRANSLATION COMPLEX OXIDOREDUCTASE NON-HEMEIRON-BINDING DSBH DIOXYGENASE JMJC DOMAIN RIBOSOME BIOGNUCLEAR PROTEIN BETA-HYDROXYLATION TRANSCRIPTION AND EPIGREGULATION SIGNALING
Ref.: RIBOSOMAL OXYGENASES ARE STRUCTURALLY CONSERVED FRO PROKARYOTES TO HUMANS. NATURE V. 510 422 2014
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 26 families.
1 4BXF - AKG C5 H6 O5 C(CC(=O)O)....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 18 families.
1 4BXF - AKG C5 H6 O5 C(CC(=O)O)....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 17 families.
1 4BXF - AKG C5 H6 O5 C(CC(=O)O)....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: AKG; Similar ligands found: 6
No: Ligand ECFP6 Tc MDL keys Tc
1 AKG 1 1
2 OOG 0.5 0.947368
3 69O 0.458333 0.714286
4 2IT 0.423077 0.615385
5 SHF 0.416667 0.666667
6 3PY 0.409091 0.652174
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4BXF; Ligand: AKG; Similar sites found: 106
This union binding pocket(no: 1) in the query (biounit: 4bxf.bio1) has 13 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4B2G V1N 0.0192 0.41211 1.13122
2 5C3R HMU 0.0001678 0.42793 1.45773
3 5C3R AKG 0.0001678 0.42793 1.45773
4 3EW2 BTN 0.01131 0.40794 1.48148
5 3W21 AKG 0.000765 0.43194 1.8315
6 3Q60 ATP 0.01087 0.41726 1.88679
7 2ET1 GLV 0.0002773 0.48025 1.99005
8 1OIK AKG 0.00003747 0.52651 1.99336
9 1OIJ AKG 0.00003218 0.49117 1.99336
10 1OIK C26 0.0001406 0.43221 1.99336
11 2OS2 OGA 0.0009655 0.45191 2.09974
12 2YBP 2HG 0.00105 0.45023 2.09974
13 5F3I 5UJ 0.001116 0.51084 2.22222
14 1GP6 SIN 0.0002095 0.52022 2.24719
15 1GP6 QUE 0.0002268 0.52022 2.24719
16 1GP6 DH2 0.0002095 0.52022 2.24719
17 3QRC SCR 0.007428 0.41736 2.54777
18 5FBN 5WF 0.03192 0.41395 2.58303
19 3NNF AKG 0.0002003 0.47251 2.61628
20 5C5T AKG 0.00003272 0.49802 2.63158
21 5FPX GLY SER SER HIS HIS HIS HIS HIS 0.0003336 0.40176 2.65487
22 4Q0L V14 0.03284 0.40286 2.6616
23 3OPT AKG 0.0002606 0.48105 2.68097
24 1U3D FAD 0.02111 0.4171 2.71493
25 1R6W 164 0.009802 0.41927 2.79503
26 4M26 SIN 0.004788 0.44812 3.02198
27 4M26 AKG 0.004697 0.41845 3.02198
28 1Z4O GL1 0.02792 0.40359 3.16742
29 2C4I BTN 0.008169 0.42409 3.32103
30 5L9V OGA 0.0002721 0.4501 3.57143
31 2JBM SRT 0.002593 0.43183 3.67893
32 5UQD AKG 0.002766 0.41867 3.84615
33 2OG7 SIN 0.001006 0.42575 3.92157
34 3FW4 CAQ 0.02681 0.40958 3.93258
35 5L9B AKG 0.0002885 0.44832 3.96825
36 4QM9 CYS 0.009768 0.40387 4.04624
37 3PUA OGA 0.002951 0.42793 4.59184
38 3KRU FMN 0.04752 0.40191 4.66472
39 3SCH TB6 0.0005696 0.45173 5.05051
40 2A4W BLM 0.03517 0.40552 5.07246
41 5JNN 6LM 0.01165 0.42647 5.26316
42 1YKD CMP 0.008095 0.4243 5.27638
43 5EPA AKG 0.0003714 0.47742 5.37634
44 2X4Z X4Z 0.009206 0.44375 5.40541
45 2QZT PLM 0.02346 0.41403 5.40541
46 1GQG DCD 0.006889 0.4357 5.42857
47 4IGQ THR M3L GLN 0.00006851 0.53544 5.55556
48 4IGQ OGA 0.0000008759 0.53544 5.55556
49 4J25 OGA 0.00001745 0.53914 5.67686
50 5HA0 LTD 0.02864 0.40727 5.76923
51 1NX4 AKG 0.001154 0.44804 5.86081
52 2IXC TRH 0.01707 0.41447 5.94059
53 3PUR 2HG 0.004992 0.41722 6.33484
54 3N9Q OGA 0.007067 0.40044 6.33484
55 5FLJ QUE 0.02358 0.40691 6.45161
56 5LUN OGA 0.00005117 0.51934 6.53409
57 5LUN ARG 0.0002804 0.51355 6.53409
58 1J3R 6PG 0.01293 0.40743 6.84211
59 3H9A PPY 0.000842 0.45959 6.99588
60 1ZN7 PRP 0.02459 0.40237 7.22222
61 3H7J PPY 0.0002428 0.43723 7.40741
62 5KOD AMP 0.01841 0.40265 7.69231
63 1DRY AAG 0.004552 0.45056 8.02469
64 1DRY AKG 0.004552 0.45056 8.02469
65 2JIG PD2 0.00002204 0.54136 8.03571
66 5TFZ 7BC 0.005349 0.4238 8.66667
67 1OS7 AKG 0.00002678 0.43167 8.83392
68 1OS7 TAU 0.00002678 0.43167 8.83392
69 1ZZ7 S0H 0.004678 0.41203 9.09091
70 1FEC FAD 0.04573 0.4161 9.72851
71 4XCB HY0 0.001265 0.47973 10.3448
72 4XCB AKG 0.0003919 0.47591 10.3448
73 3U2U UDP 0.03814 0.40791 10.6464
74 2XUM OGA 0.0000872 0.50548 11.7479
75 2Y0I AKG 0.0002422 0.48295 11.9318
76 1H2M OGA 0.00005477 0.51625 12.0344
77 1H2K OGA 0.00006086 0.51366 12.0344
78 3P3N AKG 0.00009128 0.50434 12.0344
79 4B7E OGA 0.0001618 0.49201 12.0344
80 2WA4 069 0.00008891 0.45891 12.0344
81 5M0T AKG 0.006111 0.41428 13.2653
82 4PSB GA3 0.04776 0.40456 13.5484
83 5HV0 AKG 0.00002152 0.55181 14.2857
84 4TW7 37K 0.03634 0.4022 15.625
85 4GJY OGA 0.000002605 0.58489 17.0213
86 4BKS X6C 0.01152 0.40227 19.5876
87 2FCU AKG 0.0002029 0.48799 21.0526
88 5VZ0 ADP 0.01081 0.4171 21.0526
89 5IXH OTP 0.04007 0.41537 25.4658
90 5IVE 6E8 0.0002459 0.52466 26.3158
91 4QXB OGA 0.0004147 0.4774 26.6667
92 4XAC AKG 0.0007082 0.45882 31.5789
93 5I0U DCY 0.002409 0.44245 31.5789
94 1RBL CAP 0.01582 0.41678 31.5789
95 2WYA HMG 0.02824 0.41302 31.5789
96 1WDD CAP 0.01905 0.40983 31.5789
97 1ND2 MYR 0.01437 0.40724 31.5789
98 5DQ8 FLF 0.02925 0.40402 31.5789
99 2V6A CAP 0.02438 0.40401 31.5789
100 5V1B 8UY 0.007528 0.41172 36.8421
101 3PQB VGP 0.02194 0.40912 36.8421
102 3OIX FMN 0.02796 0.40499 36.8421
103 3BU5 ATP 0.02027 0.40382 40
104 3KV5 OGA 0.004998 0.41432 42.1053
105 4MNS 2AX 0.02194 0.43504 47.3684
106 4WXG 2BO 0.02677 0.40782 47.3684
Pocket No.: 2; Query (leader) PDB : 4BXF; Ligand: AKG; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 4bxf.bio1) has 13 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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