Receptor
PDB id Resolution Class Description Source Keywords
4BDS 2.1 Å EC: 3.1.1.8 HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH TACRINE HOMO SAPIENS HYDROLASE NERVE TRANSMISSION INHIBITIOR ALPHA-BETA HYDROL
Ref.: CRYSTAL STRUCTURES OF HUMAN CHOLINESTERASES IN COMP HUPRINE W AND TACRINE: ELEMENTS OF SPECIFICITY FOR ANTI-ALZHEIMER'S DRUGS TARGETING ACETYL- AND BUTYRYLCHOLINESTERASE. BIOCHEM.J. V. 453 393 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
NAG NAG FUL C:1;
B:1;
 Invalid;
Invalid;
 none;
none;
 submit data
n/a n/a
NAG A:601;
A:611;
A:651;
A:631;
 Invalid;
Invalid;
Invalid;
Invalid;
 none;
none;
none;
none;
 submit data
221.208 C8 H15 N O6 CC(=O...
SO4 A:703;
A:704;
 Invalid;
Invalid;
 none;
none;
 submit data
96.063 O4 S [O-]S...
UNX UNX UNX UNX UNX UNX UNX A:711;
 Invalid;
 none;
 submit data
n/a n/a
FPK A:710;
 Valid;
 none;
 submit data
143.141 C6 H9 N O3 C1C[C...
GOL A:702;
 Invalid;
 none;
 submit data
92.094 C3 H8 O3 C(C(C...
CL A:706;
A:705;
 Invalid;
Invalid;
 none;
none;
 submit data
35.453 Cl [Cl-]
THA A:701;
 Valid;
 none;
 Ki = 25 nM
198.264 C13 H14 N2 c1ccc...
FUC A:612;
 Invalid;
 none;
 submit data
164.156 C6 H12 O5 C[C@H...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5NN0 2.1 Å EC: 3.1.1.8 CRYSTAL STRUCTURE OF HUBCHE WITH N-((1-(2,3-DIHYDRO-1H-INDEN PIPERIDIN-3-YL)METHYL)-N-(2-(DIMETHYLAMINO)ETHYL)-2-NAPHTHA HOMO SAPIENS BUTYRYLCHOLINESTERASE AD ALZHEIMER DISEASE INHIBITOR HYDROL
Ref.: THE MAGIC OF CRYSTAL STRUCTURE-BASED INHIBITOR OPTI DEVELOPMENT OF A BUTYRYLCHOLINESTERASE INHIBITOR WI PICOMOLAR AFFINITY AND IN VIVO ACTIVITY. J. MED. CHEM. V. 61 119 2018
Members (20)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 6QAD ic50 = 14 nM HUZ C25 H40 N4 O CCCCN[C@@H....
2 4B0O Ki = 7.3 uM 15F C15 H14 Cl3 N2 O [H]/N=C(/C....
3 6XTA ic50 = 2.8 nM O0Z C30 H42 N4 O CCCCN[C@@H....
4 4B0P Ki = 44 uM MF5 C14 H10 F5 N2 O C[n+]1cccc....
5 6SAM ic50 = 0.0645 uM L3H C21 H25 N2 O2 c1ccc(cc1)....
6 6QAB ic50 = 6.2 nM HUQ C26 H42 N3 O CCCC[N+](C....
7 5NN0 Kd = 11.1 pM 92H C30 H37 N3 O CN(C)CCN(C....
8 6QAE ic50 = 3 nM HUK C26 H45 N3 CCCC[NH+](....
9 6I0B ic50 = 9.1 nM 9A5 C30 H36 Cl N5 O c1ccc2c(c1....
10 6EQQ - H19 C18 H21 Cl N3 c1cc2c(cc1....
11 6R6W Ki = 18 nM JUB C35 H42 N7 O5 S c1ccc(cc1)....
12 6EQP Kd = 1.1 uM BUW C19 H24 N2 S CCN(CC)[C@....
13 5DYW ic50 = 4.9 nM 5HF C26 H32 N2 O3 S COCCN(C[C@....
14 1P0P - BCH C9 H20 N O S CCCC(=O)SC....
15 6R6V Ki = 88 nM JU5 C38 H45 N5 O3 S CCN(CC)c1c....
16 1P0M - CHT C5 H14 N O C[N+](C)(C....
17 6EP4 Ki = 4.5 uM DME C16 H38 N2 C[N+](C)(C....
18 4AQD - GLY C2 H5 N O2 C(C(=O)O)N
19 4BDS Ki = 25 nM THA C13 H14 N2 c1ccc2c(c1....
20 6QAA ic50 = 22 nM HUN C24 H38 N3 O CCCC[NH2+]....
70% Homology Family (118)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 6QAD ic50 = 14 nM HUZ C25 H40 N4 O CCCCN[C@@H....
2 4B0O Ki = 7.3 uM 15F C15 H14 Cl3 N2 O [H]/N=C(/C....
3 6XTA ic50 = 2.8 nM O0Z C30 H42 N4 O CCCCN[C@@H....
4 4B0P Ki = 44 uM MF5 C14 H10 F5 N2 O C[n+]1cccc....
5 6SAM ic50 = 0.0645 uM L3H C21 H25 N2 O2 c1ccc(cc1)....
6 6QAB ic50 = 6.2 nM HUQ C26 H42 N3 O CCCC[N+](C....
7 5NN0 Kd = 11.1 pM 92H C30 H37 N3 O CN(C)CCN(C....
8 6QAE ic50 = 3 nM HUK C26 H45 N3 CCCC[NH+](....
9 6I0B ic50 = 9.1 nM 9A5 C30 H36 Cl N5 O c1ccc2c(c1....
10 6EQQ - H19 C18 H21 Cl N3 c1cc2c(cc1....
11 6R6W Ki = 18 nM JUB C35 H42 N7 O5 S c1ccc(cc1)....
12 6EQP Kd = 1.1 uM BUW C19 H24 N2 S CCN(CC)[C@....
13 5DYW ic50 = 4.9 nM 5HF C26 H32 N2 O3 S COCCN(C[C@....
14 1P0P - BCH C9 H20 N O S CCCC(=O)SC....
15 6R6V Ki = 88 nM JU5 C38 H45 N5 O3 S CCN(CC)c1c....
16 1P0M - CHT C5 H14 N O C[N+](C)(C....
17 6EP4 Ki = 4.5 uM DME C16 H38 N2 C[N+](C)(C....
18 4AQD - GLY C2 H5 N O2 C(C(=O)O)N
19 4BDS Ki = 25 nM THA C13 H14 N2 c1ccc2c(c1....
20 6QAA ic50 = 22 nM HUN C24 H38 N3 O CCCC[NH2+]....
21 1Q84 Ki = 8900 fM TZ4 C42 H45 N8 c1ccc(cc1)....
22 4ARB Kd = 1.3 uM C57 C17 H26 N4 O4 CCN1CCC[C@....
23 4ARA Kd = 0.9 uM C56 C17 H26 N4 O4 CCN1CCC[C@....
24 4B80 ic50 = 40 uM A36 C13 H21 F N2 O2 S CCN(CC)CCN....
25 1N5R Ki = 2.2 uM PRM C27 H34 N4 CC[N+](C)(....
26 5EHZ Ki = 2.3 pM 5NZ C41 H43 N8 c1ccc(cc1)....
27 2HA6 - SCK C14 H30 N2 O4 C[N+](C)(C....
28 2JF0 - HBP C19 H26 N4 O2 c1cc[n+](c....
29 4B82 ic50 = 41 uM B3Z C12 H19 F N2 O2 S CCN(CC)CCN....
30 2GYU - HI6 C14 H16 N4 O3 c1cc[n+](c....
31 4B7Z ic50 = 49 uM Q4Q C14 H24 N2 O2 S CCN(CC)CCN....
32 2WHQ - HI6 C14 H16 N4 O3 c1cc[n+](c....
33 1J07 Ki = 0.021 uM DCU C32 H44 N4 C[N+](C)(C....
34 1N5M - GMN C30 H60 N3 O3 CC[N+](CC)....
35 3ZLV - HI6 C14 H16 N4 O3 c1cc[n+](c....
36 5FOQ - GC8 C20 H22 Cl2 N2 O2 c1cc(ccc1C....
37 2GYW - OBI C14 H16 N4 O3 c1c[n+](cc....
38 5FUM - SOF C25 H33 N3 O2 CCN1CCN(CC....
39 2HA0 Kd = 0.037 mM CHH C8 H18 N O CC(=O)CCC[....
40 5EIE Ki = 23000 pM TZ2 C15 H17 N5 c1ccc2c(c1....
41 4BTL ic50 = 2.5 uM 5GZ C18 H22 Cl N3 O5 S CCN(CC)CCN....
42 4B85 ic50 = 88 uM B3W C12 H19 Cl N2 O2 S CCN(CC)CCN....
43 5FPP Kd = 100 uM HI6 C14 H16 N4 O3 c1cc[n+](c....
44 2HA5 - AT3 C7 H16 N O S CC(=O)SCC[....
45 2GYV - HBP C19 H26 N4 O2 c1cc[n+](c....
46 5OV9 ic50 = 2.2 uM CVI C25 H30 N3 CN(C)c1ccc....
47 2HA2 Kd = 0.022 mM SCK C14 H30 N2 O4 C[N+](C)(C....
48 4B83 - B3V C13 H22 N2 O3 S CCN(CC)CCN....
49 4A23 ic50 = 1.3 uM C56 C17 H26 N4 O4 CCN1CCC[C@....
50 2HA3 Kd = 0.93 mM CHT C5 H14 N O C[N+](C)(C....
51 2WU4 - HBP C19 H26 N4 O2 c1cc[n+](c....
52 1ODC - A8B C30 H36 N4 c1ccc2c(c1....
53 1UT6 - A8N C21 H33 N3 c1ccc2c(c1....
54 6H14 - FW8 C35 H35 N9 O2 c1ccc2c(c1....
55 1EVE ic50 = 5.7 nM E20 C24 H29 N O3 COc1cc2c(c....
56 1H23 Ki = 4.5 nM E12 C30 H46 N4 O2 C1C[C@@H](....
57 1QTI - GNT C17 H21 N O3 C[N@@]1CC[....
58 2C4H - AT3 C7 H16 N O S CC(=O)SCC[....
59 2CEK - N8T C34 H41 N3 S c1ccc2c(c1....
60 2CMF - F11 C31 H36 N4 c1ccc2c(c1....
61 6EZG - C6K C24 H27 Cl N2 O2 COc1c2cc[n....
62 2V97 Ki ~ 20 nM CFQ C13 H19 As F3 N O3 C[As+](C)(....
63 1VOT Ki = 250 nM HUP C15 H18 N2 O C/C=C/1[C@....
64 1GPK Ki = 4.3 uM HUP C15 H18 N2 O C/C=C/1[C@....
65 6H12 - FJK C37 H41 N9 O3 c1cc2c(c(c....
66 2WG1 - FP1 C7 H10 N2 O CN1C=CC=C/....
67 4TVK - TJH C25 H22 Cl N3 O3 c1cc2c(c(c....
68 2VJB - CCD C8 H20 N O C[C@H](CCC....
69 3I6Z - G6X C29 H34 N2 O6 S COc1ccc2c3....
70 2ACK - EDR C10 H16 N O CC[N+](C)(....
71 2XI4 - AFT C17 H12 O6 COc1cc2c(c....
72 5E4T Ki = 40 nM MBT C16 H18 N3 S CN(C)c1ccc....
73 2C58 - ETM C5 H14 N S C[N+](C)(C....
74 2VJC - CHH C8 H18 N O CC(=O)CCC[....
75 6G1W - E0Z C27 H25 Cl N6 O3 COc1cc(ccc....
76 5NAP Ki = 11.12 nM DZ7 C24 H27 N O3 COc1cc2c(c....
77 1H22 Ki = 0.8 nM E10 C28 H42 N4 O2 C1C[C@@H](....
78 5BWC Ki = 0.061 uM HBP C19 H26 N4 O2 c1cc[n+](c....
79 1GQR - SAF C10 H15 N O C[C@@H](c1....
80 1DX6 ic50 = 652 nM GNT C17 H21 N O3 C[N@@]1CC[....
81 2VJD - CCD C8 H20 N O C[C@H](CCC....
82 2V96 Ki = 29 uM CFQ C13 H19 As F3 N O3 C[As+](C)(....
83 5NAU Ki = 29.86 nM DZ0 C23 H25 N O2 COc1ccc2c(....
84 2VJA - CCD C8 H20 N O C[C@H](CCC....
85 1GPN Ki = 0.334 uM HUB C16 H20 N2 O CC1=C[C@H]....
86 6G1U - E1K C14 H16 Cl N2 C[n+]1c2cc....
87 1JJB - PE7 C14 H30 O7 S C(COCCOCCO....
88 6FQN - E2W C23 H27 Cl N4 O2 c1cc2c(cc1....
89 1E66 Ki = 0.13 nM HUX C18 H19 Cl N2 CCC1=C[C@@....
90 1ZGC ic50 = 38.8 nM A2E C32 H44 N4 O c1ccc2c(c1....
91 3I6M - G3X C24 H34 N2 O3 COc1ccc2c3....
92 6FLD - NAG C8 H15 N O6 CC(=O)N[C@....
93 6G1V - E1N C19 H22 Cl N2 CCC1=C[C@@....
94 1ZGB ic50 = 8.8 nM A1E C32 H44 N4 O c1ccc2c(c1....
95 1W4L ic50 = 4 nM GL8 C32 H37 N2 O5 COc1ccc2c3....
96 2C5G - ETM C5 H14 N S C[N+](C)(C....
97 3ZV7 - NHG C11 H14 N2 O C[C@@]12CC....
98 2CKM Kd = 77 fM AA7 C33 H40 N4 c1ccc2c(c1....
99 1W76 ic50 = 702 nM GNT C17 H21 N O3 C[N@@]1CC[....
100 1W6R ic50 = 702 nM GNT C17 H21 N O3 C[N@@]1CC[....
101 4EY5 - HUP C15 H18 N2 O C/C=C/1[C@....
102 6O4X - AA C13 H11 N2 c1ccc2c(c1....
103 4EY7 - E20 C24 H29 N O3 COc1cc2c(c....
104 4M0E Ki = 0.7 uM 1YL C18 H14 O3 Cc1cccc2c1....
105 6O66 - LND C13 H16 N5 O2 c1c[n+](cc....
106 6O50 - EBW C27 H38 N2 O C[N+](C)(C....
107 5HF9 - HI6 C14 H16 N4 O3 c1cc[n+](c....
108 6U34 Ki = 157 uM PQV C10 H19 N3 O2 C1CCCN(CC1....
109 5HFA - FP1 C7 H10 N2 O CN1C=CC=C/....
110 6O5V - LND C13 H16 N5 O2 c1c[n+](cc....
111 4EY6 - GNT C17 H21 N O3 C[N@@]1CC[....
112 6CQY - VX C3 H9 O3 P CCO[P@](=O....
113 6NEA - HLO C15 H17 N5 O4 c1c[n+](cc....
114 4M0F Ki = 1.7 nM 1YK C29 H34 O9 C[C@@]12CC....
115 6CQW Kd = 0.000000064 M HI6 C14 H16 N4 O3 c1cc[n+](c....
116 6O4W - E20 C24 H29 N O3 COc1cc2c(c....
117 6CQU - HI6 C14 H16 N4 O3 c1cc[n+](c....
118 6U37 - PQV C10 H19 N3 O2 C1CCCN(CC1....
50% Homology Family (124)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 6QAD ic50 = 14 nM HUZ C25 H40 N4 O CCCCN[C@@H....
2 4B0O Ki = 7.3 uM 15F C15 H14 Cl3 N2 O [H]/N=C(/C....
3 6XTA ic50 = 2.8 nM O0Z C30 H42 N4 O CCCCN[C@@H....
4 4B0P Ki = 44 uM MF5 C14 H10 F5 N2 O C[n+]1cccc....
5 6SAM ic50 = 0.0645 uM L3H C21 H25 N2 O2 c1ccc(cc1)....
6 6QAB ic50 = 6.2 nM HUQ C26 H42 N3 O CCCC[N+](C....
7 5NN0 Kd = 11.1 pM 92H C30 H37 N3 O CN(C)CCN(C....
8 6QAE ic50 = 3 nM HUK C26 H45 N3 CCCC[NH+](....
9 6I0B ic50 = 9.1 nM 9A5 C30 H36 Cl N5 O c1ccc2c(c1....
10 6EQQ - H19 C18 H21 Cl N3 c1cc2c(cc1....
11 6R6W Ki = 18 nM JUB C35 H42 N7 O5 S c1ccc(cc1)....
12 6EQP Kd = 1.1 uM BUW C19 H24 N2 S CCN(CC)[C@....
13 5DYW ic50 = 4.9 nM 5HF C26 H32 N2 O3 S COCCN(C[C@....
14 1P0P - BCH C9 H20 N O S CCCC(=O)SC....
15 6R6V Ki = 88 nM JU5 C38 H45 N5 O3 S CCN(CC)c1c....
16 1P0M - CHT C5 H14 N O C[N+](C)(C....
17 6EP4 Ki = 4.5 uM DME C16 H38 N2 C[N+](C)(C....
18 4AQD - GLY C2 H5 N O2 C(C(=O)O)N
19 4BDS Ki = 25 nM THA C13 H14 N2 c1ccc2c(c1....
20 6QAA ic50 = 22 nM HUN C24 H38 N3 O CCCC[NH2+]....
21 5EHQ Ki = 33 pM 5O2 C41 H43 N8 c1ccc(cc1)....
22 1Q84 Ki = 8900 fM TZ4 C42 H45 N8 c1ccc(cc1)....
23 4ARB Kd = 1.3 uM C57 C17 H26 N4 O4 CCN1CCC[C@....
24 4ARA Kd = 0.9 uM C56 C17 H26 N4 O4 CCN1CCC[C@....
25 4B80 ic50 = 40 uM A36 C13 H21 F N2 O2 S CCN(CC)CCN....
26 1N5R Ki = 2.2 uM PRM C27 H34 N4 CC[N+](C)(....
27 5EHZ Ki = 2.3 pM 5NZ C41 H43 N8 c1ccc(cc1)....
28 2HA6 - SCK C14 H30 N2 O4 C[N+](C)(C....
29 2JF0 - HBP C19 H26 N4 O2 c1cc[n+](c....
30 4B82 ic50 = 41 uM B3Z C12 H19 F N2 O2 S CCN(CC)CCN....
31 2GYU - HI6 C14 H16 N4 O3 c1cc[n+](c....
32 4B7Z ic50 = 49 uM Q4Q C14 H24 N2 O2 S CCN(CC)CCN....
33 2WHQ - HI6 C14 H16 N4 O3 c1cc[n+](c....
34 1J07 Ki = 0.021 uM DCU C32 H44 N4 C[N+](C)(C....
35 1N5M - GMN C30 H60 N3 O3 CC[N+](CC)....
36 3ZLV - HI6 C14 H16 N4 O3 c1cc[n+](c....
37 5FOQ - GC8 C20 H22 Cl2 N2 O2 c1cc(ccc1C....
38 2GYW - OBI C14 H16 N4 O3 c1c[n+](cc....
39 5FUM - SOF C25 H33 N3 O2 CCN1CCN(CC....
40 2HA0 Kd = 0.037 mM CHH C8 H18 N O CC(=O)CCC[....
41 5EIE Ki = 23000 pM TZ2 C15 H17 N5 c1ccc2c(c1....
42 4BTL ic50 = 2.5 uM 5GZ C18 H22 Cl N3 O5 S CCN(CC)CCN....
43 4B85 ic50 = 88 uM B3W C12 H19 Cl N2 O2 S CCN(CC)CCN....
44 5FPP Kd = 100 uM HI6 C14 H16 N4 O3 c1cc[n+](c....
45 2HA5 - AT3 C7 H16 N O S CC(=O)SCC[....
46 2GYV - HBP C19 H26 N4 O2 c1cc[n+](c....
47 5OV9 ic50 = 2.2 uM CVI C25 H30 N3 CN(C)c1ccc....
48 2HA2 Kd = 0.022 mM SCK C14 H30 N2 O4 C[N+](C)(C....
49 4B83 - B3V C13 H22 N2 O3 S CCN(CC)CCN....
50 4A23 ic50 = 1.3 uM C56 C17 H26 N4 O4 CCN1CCC[C@....
51 2HA3 Kd = 0.93 mM CHT C5 H14 N O C[N+](C)(C....
52 2WU4 - HBP C19 H26 N4 O2 c1cc[n+](c....
53 1ODC - A8B C30 H36 N4 c1ccc2c(c1....
54 1UT6 - A8N C21 H33 N3 c1ccc2c(c1....
55 6H14 - FW8 C35 H35 N9 O2 c1ccc2c(c1....
56 1EVE ic50 = 5.7 nM E20 C24 H29 N O3 COc1cc2c(c....
57 1H23 Ki = 4.5 nM E12 C30 H46 N4 O2 C1C[C@@H](....
58 1QTI - GNT C17 H21 N O3 C[N@@]1CC[....
59 2C4H - AT3 C7 H16 N O S CC(=O)SCC[....
60 2CEK - N8T C34 H41 N3 S c1ccc2c(c1....
61 2CMF - F11 C31 H36 N4 c1ccc2c(c1....
62 6EZG - C6K C24 H27 Cl N2 O2 COc1c2cc[n....
63 2V97 Ki ~ 20 nM CFQ C13 H19 As F3 N O3 C[As+](C)(....
64 1VOT Ki = 250 nM HUP C15 H18 N2 O C/C=C/1[C@....
65 1GPK Ki = 4.3 uM HUP C15 H18 N2 O C/C=C/1[C@....
66 6H12 - FJK C37 H41 N9 O3 c1cc2c(c(c....
67 2WG1 - FP1 C7 H10 N2 O CN1C=CC=C/....
68 4TVK - TJH C25 H22 Cl N3 O3 c1cc2c(c(c....
69 2VJB - CCD C8 H20 N O C[C@H](CCC....
70 3I6Z - G6X C29 H34 N2 O6 S COc1ccc2c3....
71 2ACK - EDR C10 H16 N O CC[N+](C)(....
72 2XI4 - AFT C17 H12 O6 COc1cc2c(c....
73 5E4T Ki = 40 nM MBT C16 H18 N3 S CN(C)c1ccc....
74 2C58 - ETM C5 H14 N S C[N+](C)(C....
75 2VJC - CHH C8 H18 N O CC(=O)CCC[....
76 6G1W - E0Z C27 H25 Cl N6 O3 COc1cc(ccc....
77 5NAP Ki = 11.12 nM DZ7 C24 H27 N O3 COc1cc2c(c....
78 1H22 Ki = 0.8 nM E10 C28 H42 N4 O2 C1C[C@@H](....
79 5BWC Ki = 0.061 uM HBP C19 H26 N4 O2 c1cc[n+](c....
80 1GQR - SAF C10 H15 N O C[C@@H](c1....
81 1DX6 ic50 = 652 nM GNT C17 H21 N O3 C[N@@]1CC[....
82 2VJD - CCD C8 H20 N O C[C@H](CCC....
83 2V96 Ki = 29 uM CFQ C13 H19 As F3 N O3 C[As+](C)(....
84 5NAU Ki = 29.86 nM DZ0 C23 H25 N O2 COc1ccc2c(....
85 2VJA - CCD C8 H20 N O C[C@H](CCC....
86 1GPN Ki = 0.334 uM HUB C16 H20 N2 O CC1=C[C@H]....
87 6G1U - E1K C14 H16 Cl N2 C[n+]1c2cc....
88 1JJB - PE7 C14 H30 O7 S C(COCCOCCO....
89 6FQN - E2W C23 H27 Cl N4 O2 c1cc2c(cc1....
90 1E66 Ki = 0.13 nM HUX C18 H19 Cl N2 CCC1=C[C@@....
91 1ZGC ic50 = 38.8 nM A2E C32 H44 N4 O c1ccc2c(c1....
92 3I6M - G3X C24 H34 N2 O3 COc1ccc2c3....
93 6FLD - NAG C8 H15 N O6 CC(=O)N[C@....
94 6G1V - E1N C19 H22 Cl N2 CCC1=C[C@@....
95 1ZGB ic50 = 8.8 nM A1E C32 H44 N4 O c1ccc2c(c1....
96 1W4L ic50 = 4 nM GL8 C32 H37 N2 O5 COc1ccc2c3....
97 2C5G - ETM C5 H14 N S C[N+](C)(C....
98 3ZV7 - NHG C11 H14 N2 O C[C@@]12CC....
99 2CKM Kd = 77 fM AA7 C33 H40 N4 c1ccc2c(c1....
100 1W76 ic50 = 702 nM GNT C17 H21 N O3 C[N@@]1CC[....
101 1W6R ic50 = 702 nM GNT C17 H21 N O3 C[N@@]1CC[....
102 1MX1 - THA C13 H14 N2 c1ccc2c(c1....
103 2H7C - SIA C11 H19 N O9 CC(=O)N[C@....
104 1K4Y - 4PN C10 H20 N2 C1CCN(CC1)....
105 4EY5 - HUP C15 H18 N2 O C/C=C/1[C@....
106 6O4X - AA C13 H11 N2 c1ccc2c(c1....
107 4EY7 - E20 C24 H29 N O3 COc1cc2c(c....
108 4M0E Ki = 0.7 uM 1YL C18 H14 O3 Cc1cccc2c1....
109 6O66 - LND C13 H16 N5 O2 c1c[n+](cc....
110 6O50 - EBW C27 H38 N2 O C[N+](C)(C....
111 5HF9 - HI6 C14 H16 N4 O3 c1cc[n+](c....
112 6U34 Ki = 157 uM PQV C10 H19 N3 O2 C1CCCN(CC1....
113 5HFA - FP1 C7 H10 N2 O CN1C=CC=C/....
114 6O5V - LND C13 H16 N5 O2 c1c[n+](cc....
115 4EY6 - GNT C17 H21 N O3 C[N@@]1CC[....
116 6CQY - VX C3 H9 O3 P CCO[P@](=O....
117 6NEA - HLO C15 H17 N5 O4 c1c[n+](cc....
118 4M0F Ki = 1.7 nM 1YK C29 H34 O9 C[C@@]12CC....
119 6CQW Kd = 0.000000064 M HI6 C14 H16 N4 O3 c1cc[n+](c....
120 6O4W - E20 C24 H29 N O3 COc1cc2c(c....
121 6CQU - HI6 C14 H16 N4 O3 c1cc[n+](c....
122 6U37 - PQV C10 H19 N3 O2 C1CCCN(CC1....
123 6ARX - FLC C6 H5 O7 C(C(=O)[O-....
124 6ARY - FLC C6 H5 O7 C(C(=O)[O-....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: FPK; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 FPK 1 1
2 N8P 0.4 0.9
3 N7P 0.4 0.9
Ligand no: 2; Ligand: THA; Similar ligands found: 4
No: Ligand ECFP6 Tc MDL keys Tc
1 THA 1 1
2 F11 0.484375 0.763158
3 AA7 0.476923 0.763158
4 TZ2 0.416667 0.644444
Similar Ligands (3D)
Ligand no: 1; Ligand: FPK; Similar ligands found: 761
No: Ligand Similarity coefficient
1 8EZ 0.9636
2 3SK 0.9590
3 FP1 0.9568
4 VNJ 0.9541
5 RSF 0.9513
6 JKE 0.9506
7 TMH 0.9503
8 3U4 0.9479
9 7HP 0.9465
10 BE2 0.9463
11 SAL 0.9460
12 OEM 0.9432
13 1WD 0.9401
14 ADE 0.9386
15 HPA 0.9366
16 6UA 0.9337
17 7WV 0.9335
18 ASP 0.9330
19 12M 0.9326
20 286 0.9319
21 4SV 0.9319
22 NTM 0.9316
23 2DR 0.9297
24 PRY 0.9295
25 IP0 0.9289
26 ES6 0.9283
27 GUN 0.9283
28 JZ3 0.9280
29 FUL 0.9279
30 CIZ 0.9276
31 XAN 0.9274
32 JZ4 0.9274
33 FCB 0.9271
34 IPZ 0.9267
35 261 0.9265
36 LSA 0.9263
37 ARB 0.9255
38 BSX 0.9254
39 1LN 0.9251
40 60P 0.9247
41 XYP 0.9242
42 KLW 0.9238
43 AHR 0.9231
44 RM4 0.9230
45 KYD 0.9229
46 51F 0.9228
47 5AC 0.9227
48 BDR 0.9225
49 BTE 0.9220
50 PHT 0.9219
51 PRZ 0.9218
52 JZ1 0.9217
53 7WA 0.9217
54 9DG 0.9211
55 4PW 0.9211
56 2TQ 0.9210
57 RNS 0.9208
58 TZE 0.9205
59 NEQ 0.9201
60 6JN 0.9197
61 RIP 0.9194
62 RAM 0.9189
63 MFB 0.9187
64 R8A 0.9186
65 AUD 0.9186
66 RIB 0.9178
67 NK 0.9176
68 40O 0.9175
69 2XX 0.9174
70 URA 0.9173
71 O7U 0.9171
72 MEV 0.9167
73 GIF 0.9167
74 Z6J 0.9166
75 278 0.9164
76 FPY 0.9164
77 DOR 0.9160
78 GLY PRO 0.9159
79 10L 0.9159
80 9HX 0.9156
81 FUB 0.9153
82 XYS 0.9152
83 URF 0.9152
84 1P3 0.9152
85 6M1 0.9151
86 6F0 0.9148
87 9DA 0.9147
88 64K 0.9145
89 GAG 0.9142
90 FB1 0.9139
91 GBD 0.9139
92 FBV 0.9139
93 PM6 0.9137
94 OXQ 0.9132
95 26D 0.9132
96 BP1 0.9131
97 GRE 0.9131
98 280 0.9129
99 0TR 0.9127
100 ARA 0.9126
101 AZA 0.9124
102 2LP 0.9124
103 NFQ 0.9124
104 MLT 0.9122
105 TLA 0.9121
106 URQ 0.9121
107 GLC 0.9120
108 6MP 0.9120
109 0R0 0.9118
110 FUC 0.9116
111 HDA 0.9115
112 ASN 0.9113
113 0MK 0.9110
114 TAR 0.9109
115 2ZV 0.9108
116 FYU 0.9108
117 I3A 0.9108
118 9TZ 0.9107
119 TDR 0.9105
120 DBJ 0.9105
121 CAQ 0.9102
122 HY3 0.9101
123 WDL 0.9100
124 HH5 0.9097
125 WBU 0.9097
126 MAN 0.9097
127 GYE 0.9096
128 BMA 0.9095
129 IDH 0.9095
130 CRS 0.9094
131 G5V 0.9093
132 GIV 0.9090
133 DFU 0.9089
134 5RG 0.9088
135 GIO 0.9088
136 3AY 0.9088
137 HGQ 0.9088
138 141 0.9087
139 329 0.9087
140 AX2 0.9084
141 IGA 0.9083
142 BR8 0.9083
143 GLU 0.9083
144 AZG 0.9082
145 FUF 0.9081
146 47J 0.9078
147 LMR 0.9078
148 DFB 0.9076
149 LXC 0.9076
150 DUC 0.9073
151 13X 0.9073
152 HXX 0.9072
153 5M0 0.9071
154 A2F 0.9069
155 6M4 0.9068
156 GTQ 0.9066
157 SYG 0.9064
158 XXR 0.9064
159 JBE 0.9063
160 YAN 0.9063
161 284 0.9061
162 6AP 0.9059
163 ICP 0.9059
164 NOJ 0.9058
165 GAL 0.9057
166 290 0.9054
167 8EW 0.9053
168 1LQ 0.9052
169 XUL 0.9051
170 NMJ 0.9051
171 BEW 0.9050
172 RBL 0.9049
173 YHO 0.9049
174 VAH 0.9049
175 54G 0.9049
176 PBE 0.9048
177 H76 0.9047
178 SC2 0.9045
179 LER 0.9045
180 YTB 0.9044
181 2AF 0.9044
182 AGK 0.9042
183 93Q 0.9035
184 938 0.9034
185 3ZQ 0.9034
186 5AN 0.9030
187 24B 0.9030
188 OXE 0.9030
189 32O 0.9028
190 PYG 0.9028
191 DAB 0.9027
192 ENL 0.9027
193 HQY 0.9025
194 DZX 0.9025
195 5MK 0.9024
196 JZ0 0.9023
197 ILE 0.9022
198 HSE 0.9021
199 6LW 0.9021
200 5UC 0.9020
201 GOO 0.9020
202 5ZE 0.9018
203 2CH 0.9017
204 ASC 0.9017
205 CRN 0.9016
206 Q6T 0.9016
207 N5J 0.9016
208 5WX 0.9015
209 CFP 0.9015
210 SWA 0.9015
211 5IQ 0.9014
212 OAA 0.9013
213 XQG 0.9011
214 7HQ 0.9011
215 GLA 0.9010
216 PAF 0.9009
217 9TY 0.9009
218 G2H 0.9009
219 HTS 0.9009
220 76X 0.9009
221 5Q0 0.9008
222 1AN 0.9006
223 92Z 0.9005
224 1NP 0.9005
225 L89 0.9004
226 FBT 0.9002
227 SWD 0.9001
228 HPY 0.9001
229 NSP 0.9000
230 ES4 0.8998
231 FP2 0.8998
232 1XM 0.8998
233 ALO 0.8998
234 7CZ 0.8995
235 G4D 0.8995
236 5SG 0.8995
237 2PG 0.8994
238 G3F 0.8993
239 DX4 0.8993
240 4YS 0.8993
241 8LG 0.8993
242 TRA 0.8992
243 VAL 0.8992
244 SHA 0.8990
245 6CS 0.8989
246 THR 0.8988
247 JZ9 0.8988
248 1XN 0.8988
249 YH7 0.8986
250 2FG 0.8985
251 SF9 0.8983
252 ERH 0.8983
253 SX1 0.8982
254 G8M 0.8982
255 AH8 0.8982
256 ES1 0.8981
257 285 0.8981
258 6KX 0.8981
259 YQA 0.8980
260 2MN 0.8979
261 BGC 0.8978
262 3XX 0.8977
263 BOA 0.8977
264 IDM 0.8973
265 3NT 0.8973
266 CTL 0.8972
267 2MP 0.8972
268 DIG 0.8971
269 3MA 0.8971
270 ADK 0.8971
271 1XX 0.8970
272 SVN 0.8970
273 43M 0.8970
274 JPZ 0.8970
275 JBH 0.8970
276 ZZT 0.8969
277 1PT 0.8969
278 ZZ3 0.8969
279 3DO 0.8968
280 S76 0.8967
281 149 0.8967
282 M0W 0.8967
283 GOG 0.8966
284 ITN 0.8966
285 ROR 0.8966
286 6GU 0.8965
287 IFM 0.8964
288 2ZX 0.8964
289 3Z7 0.8963
290 G2F 0.8963
291 T9G 0.8961
292 QOS 0.8960
293 A1U 0.8960
294 PYD 0.8957
295 TH7 0.8956
296 NVA 0.8955
297 98J 0.8955
298 YIO 0.8954
299 4ZE 0.8954
300 4CS 0.8953
301 0CT 0.8952
302 EXO 0.8952
303 FCA 0.8951
304 TM7 0.8951
305 1MC 0.8950
306 HZP 0.8949
307 THE 0.8945
308 IOM 0.8945
309 F81 0.8945
310 42C 0.8944
311 1LM 0.8943
312 HLZ 0.8940
313 1GN 0.8940
314 34A 0.8939
315 O72 0.8939
316 9EW 0.8936
317 DBX 0.8936
318 7VS 0.8935
319 BZX 0.8935
320 1WG 0.8934
321 HJP 0.8934
322 24W 0.8933
323 EDG 0.8932
324 ORO 0.8931
325 SXS 0.8931
326 ARW 0.8931
327 8S0 0.8931
328 L3Q 0.8931
329 JIF 0.8929
330 3HA 0.8929
331 PA1 0.8927
332 SEJ 0.8927
333 B53 0.8926
334 EYK 0.8926
335 XYD 0.8925
336 H3M 0.8924
337 2A7 0.8924
338 5DI 0.8923
339 9X7 0.8923
340 1DW 0.8922
341 23A 0.8921
342 2YU 0.8921
343 25W 0.8921
344 CNL 0.8921
345 XBZ 0.8920
346 MRZ 0.8919
347 CDV 0.8919
348 IND 0.8918
349 6HQ 0.8918
350 1SQ 0.8915
351 F05 0.8913
352 MWM 0.8913
353 TH0 0.8913
354 NDH 0.8912
355 0W8 0.8911
356 260 0.8910
357 M2H 0.8909
358 6X8 0.8909
359 AC5 0.8908
360 3RK 0.8907
361 DXX 0.8907
362 MNM 0.8907
363 HMU 0.8906
364 LRH 0.8906
365 G6D 0.8906
366 9MG 0.8903
367 OXZ 0.8900
368 7B4 0.8900
369 Q88 0.8899
370 AIN 0.8898
371 HT4 0.8898
372 150 0.8896
373 GAF 0.8895
374 AZF 0.8894
375 RP7 0.8891
376 2CQ 0.8890
377 BCP 0.8890
378 3MC 0.8889
379 FLM 0.8889
380 INS 0.8888
381 ZWZ 0.8887
382 CWM 0.8886
383 MPI 0.8885
384 LDU 0.8885
385 GAB 0.8885
386 6M9 0.8884
387 6AI 0.8884
388 LEU 0.8883
389 3FA 0.8883
390 KIV 0.8881
391 AKH 0.8881
392 HCS 0.8880
393 BZI 0.8880
394 MCT 0.8878
395 PSV 0.8876
396 DBH 0.8875
397 DEN 0.8874
398 HMH 0.8873
399 PRO 0.8873
400 5MH 0.8872
401 ES0 0.8872
402 HLR 0.8871
403 GM7 0.8871
404 3F0 0.8871
405 R1X 0.8870
406 R2B 0.8870
407 45C 0.8870
408 M1H 0.8869
409 P3K 0.8869
410 3DM 0.8868
411 FRU 0.8868
412 QAT 0.8868
413 GT0 0.8868
414 MSN 0.8867
415 ADZ 0.8866
416 23W 0.8866
417 V55 0.8861
418 4XH 0.8861
419 NPY 0.8860
420 KPL 0.8860
421 4XR 0.8859
422 2H5 0.8858
423 PE0 0.8858
424 2AC 0.8858
425 4JJ 0.8856
426 XLS 0.8855
427 HA7 0.8855
428 GMN 0.8855
429 RM1 0.8854
430 2CK 0.8854
431 AKB 0.8853
432 WTZ 0.8853
433 3HB 0.8853
434 YSO 0.8852
435 ISD 0.8852
436 4JP 0.8852
437 KBB 0.8852
438 VPR 0.8851
439 MMZ 0.8851
440 FA0 0.8850
441 SRT 0.8850
442 QAS 0.8850
443 XSP 0.8849
444 PXL 0.8849
445 MBD 0.8849
446 GXL 0.8849
447 GVH 0.8848
448 IUR 0.8848
449 BZF 0.8848
450 4ZC 0.8846
451 4HO 0.8846
452 BAM 0.8846
453 7MH 0.8845
454 LGC 0.8845
455 0R1 0.8844
456 MFU 0.8844
457 C2A 0.8843
458 T6C 0.8843
459 BFM 0.8843
460 GZ8 0.8843
461 LNO 0.8842
462 HHA 0.8842
463 5JC 0.8841
464 IMR 0.8840
465 2C9 0.8840
466 TLD 0.8840
467 4JO 0.8839
468 SS2 0.8839
469 RCO 0.8839
470 PEZ 0.8838
471 LZ1 0.8838
472 KBG 0.8835
473 8H8 0.8835
474 DMJ 0.8835
475 5NU 0.8832
476 5RN 0.8832
477 4RW 0.8831
478 JZ2 0.8830
479 ZXD 0.8830
480 IPM 0.8829
481 NIO 0.8829
482 BDF 0.8828
483 QUZ 0.8827
484 MWJ 0.8827
485 0CU 0.8826
486 27Y 0.8826
487 B0D 0.8826
488 DTL 0.8825
489 8TX 0.8824
490 53C 0.8824
491 PEP 0.8824
492 BHA 0.8823
493 MBG 0.8822
494 3M0 0.8822
495 VGL 0.8820
496 LG3 0.8820
497 GJS 0.8820
498 OXC 0.8819
499 IFL 0.8818
500 DAS 0.8816
501 TFB 0.8814
502 NCD 0.8813
503 OVV 0.8812
504 KSW 0.8812
505 PXM 0.8812
506 TEO 0.8812
507 JFD 0.8812
508 2MY 0.8812
509 CYT 0.8810
510 ABE 0.8810
511 UEG 0.8810
512 2ZQ 0.8808
513 PAV 0.8807
514 0RW 0.8807
515 HH8 0.8805
516 IPB 0.8803
517 MAK 0.8803
518 SHG 0.8801
519 V6F 0.8801
520 5MB 0.8801
521 5CU 0.8799
522 MMA 0.8798
523 NCA 0.8797
524 DOB 0.8797
525 BR9 0.8797
526 14O 0.8796
527 4DX 0.8796
528 LG5 0.8795
529 FLC 0.8794
530 NOY 0.8791
531 AZ8 0.8790
532 QDK 0.8789
533 DGJ 0.8789
534 6PC 0.8789
535 CGB 0.8787
536 MLE 0.8786
537 7NI 0.8786
538 URC 0.8785
539 EUG 0.8783
540 DPF 0.8783
541 F60 0.8781
542 DIE 0.8780
543 GLF 0.8779
544 6MH 0.8778
545 TC7 0.8776
546 AMC 0.8775
547 RHU 0.8775
548 Y8I 0.8775
549 SOE 0.8774
550 67N 0.8774
551 5H1 0.8774
552 WOO 0.8774
553 MB3 0.8774
554 SRO 0.8773
555 1AL 0.8773
556 2K4 0.8772
557 4CL 0.8771
558 FLA 0.8771
559 MET 0.8770
560 IJZ 0.8770
561 DMD 0.8768
562 FFP 0.8768
563 SFU 0.8768
564 2CM 0.8767
565 X09 0.8766
566 34V 0.8766
567 4M0 0.8766
568 PZI 0.8764
569 NXA 0.8763
570 GCS 0.8762
571 FPI 0.8761
572 8GF 0.8761
573 KKN 0.8761
574 7N0 0.8760
575 MZG 0.8760
576 F4Z 0.8760
577 CIT 0.8759
578 DUB 0.8759
579 ASO 0.8758
580 5MI 0.8757
581 K6H 0.8757
582 RUU 0.8757
583 F5B 0.8756
584 ISN 0.8756
585 MWP 0.8756
586 X6X 0.8756
587 M1E 0.8755
588 BEZ 0.8755
589 3MH 0.8754
590 NTN 0.8753
591 ECE 0.8753
592 3CE 0.8752
593 AQO 0.8752
594 Q24 0.8751
595 192 0.8751
596 SYN 0.8750
597 IQ0 0.8750
598 ICC 0.8749
599 7W4 0.8747
600 D1X 0.8747
601 IHG 0.8746
602 282 0.8746
603 TCZ 0.8745
604 ISE 0.8745
605 HIO 0.8744
606 BEN 0.8743
607 4HC 0.8741
608 7D2 0.8741
609 MEW 0.8741
610 ES9 0.8739
611 5OB 0.8739
612 J9W 0.8737
613 YCP 0.8736
614 DCD 0.8735
615 1AB 0.8735
616 FOT 0.8734
617 B3R 0.8733
618 BVF 0.8733
619 23B 0.8733
620 3WA 0.8733
621 3CH 0.8732
622 QFH 0.8730
623 TM4 0.8728
624 R9S 0.8728
625 H4N 0.8728
626 42A 0.8726
627 IF7 0.8723
628 R8S 0.8723
629 VNL 0.8723
630 FDB 0.8722
631 LZM 0.8721
632 HEW 0.8720
633 11S 0.8718
634 LCN 0.8717
635 B55 0.8717
636 82I 0.8716
637 DPR 0.8715
638 3BZ 0.8714
639 BHO 0.8714
640 8IG 0.8714
641 ALL 0.8713
642 DTI 0.8713
643 NK2 0.8712
644 32X 0.8712
645 SKG 0.8711
646 M1A 0.8709
647 AMG 0.8707
648 UNC 0.8707
649 M5K 0.8707
650 CIG 0.8704
651 3AB 0.8704
652 FK1 0.8703
653 495 0.8702
654 GLT 0.8701
655 II6 0.8701
656 I2M 0.8701
657 HZQ 0.8700
658 KIB 0.8700
659 KIA 0.8700
660 3IT 0.8699
661 ABN 0.8698
662 8GC 0.8698
663 RPQ 0.8697
664 ICF 0.8695
665 TFU 0.8695
666 I1N 0.8694
667 CYS 0.8693
668 RB0 0.8691
669 COI 0.8690
670 4TE 0.8688
671 BTY 0.8687
672 SF6 0.8687
673 AW5 0.8686
674 2D0 0.8684
675 AJ2 0.8683
676 M1Q 0.8680
677 CAE 0.8680
678 XM0 0.8676
679 HSL 0.8673
680 4XX 0.8673
681 ZZ8 0.8672
682 F0J 0.8672
683 M3T 0.8672
684 WCE 0.8671
685 SIF 0.8671
686 270 0.8670
687 IT9 0.8670
688 KJY 0.8670
689 0P6 0.8668
690 HIU 0.8668
691 KOJ 0.8668
692 APY 0.8668
693 3ID 0.8666
694 5HN 0.8666
695 BNS 0.8665
696 8NY 0.8664
697 SKM 0.8663
698 39A 0.8663
699 9RW 0.8662
700 R8V 0.8658
701 PZA 0.8658
702 M0Q 0.8654
703 4AX 0.8654
704 7VJ 0.8652
705 DHQ 0.8651
706 CTS 0.8651
707 LFR 0.8649
708 MO8 0.8647
709 94B 0.8646
710 3FH 0.8645
711 MRY 0.8644
712 J1Z 0.8643
713 MT0 0.8641
714 34D 0.8641
715 4H2 0.8640
716 GTR 0.8640
717 AFR 0.8639
718 2MI 0.8638
719 EV0 0.8638
720 4JT 0.8637
721 DHK 0.8633
722 GLY CYS 0.8632
723 2CL 0.8631
724 3Z8 0.8625
725 SER 0.8625
726 F12 0.8625
727 OHP 0.8624
728 A7W 0.8623
729 1U1 0.8623
730 COU 0.8621
731 NBZ 0.8617
732 4NC 0.8617
733 AX7 0.8616
734 CCB 0.8615
735 75K 0.8605
736 PRS 0.8605
737 SVJ 0.8605
738 GYP 0.8604
739 1DJ 0.8598
740 MZB 0.8596
741 5JL 0.8595
742 SPV 0.8593
743 C2U 0.8590
744 FDK 0.8584
745 PYJ 0.8584
746 273 0.8583
747 FH2 0.8582
748 KDF 0.8582
749 OMD 0.8577
750 0LH 0.8572
751 EA1 0.8570
752 MED 0.8567
753 CXF 0.8561
754 8OZ 0.8557
755 AS3 0.8556
756 MD0 0.8545
757 2BN 0.8536
758 UNU 0.8533
759 D3M 0.8529
760 LKA 0.8521
761 MRW 0.8520
Ligand no: 2; Ligand: THA; Similar ligands found: 837
No: Ligand Similarity coefficient
1 ANF 0.9989
2 AA 0.9983
3 3J8 0.9790
4 DNA 0.9718
5 AN3 0.9704
6 ANC 0.9698
7 1HN 0.9669
8 PEY 0.9663
9 DRG 0.9661
10 8MO 0.9646
11 GJP 0.9644
12 6QF 0.9642
13 E1K 0.9629
14 6FB 0.9619
15 4RU 0.9613
16 KYA 0.9599
17 H5B 0.9591
18 BZJ 0.9580
19 X0U 0.9569
20 9FL 0.9554
21 DPT 0.9552
22 30G 0.9541
23 ST2 0.9518
24 9CA 0.9500
25 PJW 0.9498
26 1IT 0.9494
27 CH9 0.9482
28 27B 0.9482
29 FDR 0.9482
30 MD6 0.9474
31 537 0.9471
32 9AP 0.9466
33 LDR 0.9460
34 15N 0.9452
35 E1T 0.9451
36 ZYR 0.9446
37 0JD 0.9444
38 PRL 0.9437
39 54X 0.9437
40 FQX 0.9426
41 SLS 0.9417
42 N1E 0.9414
43 8XL 0.9414
44 4KL 0.9402
45 BPY 0.9395
46 2FQ 0.9395
47 GNM 0.9389
48 5TY 0.9381
49 KMY 0.9379
50 BIK 0.9375
51 3R4 0.9375
52 CKA 0.9369
53 9ZE 0.9358
54 9UL 0.9350
55 B56 0.9348
56 2GQ 0.9347
57 HQD 0.9337
58 5VL 0.9326
59 6KT 0.9322
60 2K8 0.9321
61 68A 0.9317
62 344 0.9309
63 1F1 0.9309
64 2JK 0.9308
65 0N7 0.9305
66 HA5 0.9303
67 IQZ 0.9300
68 JG8 0.9300
69 BA5 0.9298
70 OQC 0.9296
71 92P 0.9290
72 N0Z 0.9284
73 GO2 0.9277
74 1VK 0.9275
75 12T 0.9272
76 8HC 0.9271
77 0HO 0.9268
78 DK1 0.9268
79 SKF 0.9267
80 0FK 0.9267
81 363 0.9263
82 M4E 0.9261
83 0FR 0.9259
84 2LY 0.9258
85 M5H 0.9257
86 44V 0.9254
87 C2Y 0.9251
88 PH2 0.9248
89 2KA 0.9245
90 QX4 0.9244
91 6VD 0.9243
92 3VX 0.9243
93 LL1 0.9242
94 9TF 0.9239
95 KF5 0.9238
96 ESX 0.9238
97 TIY 0.9237
98 6NI 0.9236
99 V1T 0.9232
100 X11 0.9231
101 JTA 0.9227
102 0HN 0.9226
103 4TU 0.9224
104 JAW 0.9223
105 2ZM 0.9222
106 TXW 0.9221
107 ESP 0.9221
108 6NT 0.9220
109 8ZE 0.9219
110 3QV 0.9217
111 HRM 0.9216
112 4I8 0.9216
113 N91 0.9212
114 LFN 0.9212
115 9R5 0.9210
116 JB8 0.9209
117 5VJ 0.9209
118 AJY 0.9208
119 GNV 0.9207
120 JDN 0.9207
121 CLZ 0.9204
122 0F9 0.9202
123 97T 0.9201
124 HHS 0.9198
125 3A9 0.9197
126 3NY 0.9195
127 1A7 0.9193
128 XCG 0.9193
129 VUP 0.9190
130 N2M 0.9189
131 DQU 0.9187
132 2HU 0.9186
133 NAG 0.9183
134 IAC 0.9183
135 1KP 0.9182
136 BQ2 0.9179
137 6ME 0.9177
138 5NI 0.9175
139 HHR 0.9175
140 ABI 0.9173
141 NRA 0.9173
142 Z21 0.9172
143 HBO 0.9171
144 AZ9 0.9168
145 ZHA 0.9168
146 FCD 0.9167
147 G12 0.9166
148 TMG 0.9165
149 VK3 0.9163
150 OTW 0.9161
151 S0E 0.9158
152 JP2 0.9156
153 4BY 0.9154
154 Z5P 0.9153
155 GF4 0.9152
156 XHP 0.9151
157 CK2 0.9150
158 B62 0.9147
159 X48 0.9146
160 KTW 0.9146
161 BGU 0.9145
162 7FF 0.9140
163 2FY 0.9137
164 S60 0.9137
165 ZSP 0.9136
166 5V7 0.9131
167 BGC 0.9128
168 44W 0.9127
169 BZ2 0.9126
170 TOF 0.9126
171 II4 0.9119
172 TCR 0.9118
173 MS9 0.9116
174 N2I 0.9114
175 5GT 0.9113
176 BIO 0.9106
177 N8Y 0.9104
178 MVN 0.9102
179 94W 0.9099
180 15E 0.9097
181 BP7 0.9095
182 KDV 0.9094
183 AP4 0.9094
184 LI6 0.9094
185 LQ2 0.9092
186 9KZ 0.9091
187 ODO 0.9090
188 4NB 0.9089
189 APS 0.9088
190 3ZB 0.9088
191 9KT 0.9086
192 PRF 0.9086
193 BPU 0.9084
194 X8D 0.9084
195 2FX 0.9083
196 4BL 0.9081
197 4AB 0.9081
198 EUE 0.9081
199 0FN 0.9081
200 TT4 0.9079
201 ITE 0.9079
202 J9Q 0.9079
203 EN1 0.9077
204 28N 0.9077
205 CNI 0.9076
206 HBI 0.9076
207 K44 0.9075
208 P9E 0.9073
209 BNX 0.9072
210 5E5 0.9071
211 XDK 0.9070
212 ARP 0.9069
213 ICO 0.9069
214 CWJ 0.9068
215 D48 0.9067
216 ESI 0.9062
217 1QP 0.9062
218 H4B 0.9061
219 A7H 0.9059
220 TXQ 0.9059
221 49O 0.9059
222 SNO 0.9059
223 4JQ 0.9058
224 ICB 0.9058
225 M6Z 0.9058
226 8NX 0.9057
227 6BL 0.9057
228 5RO 0.9056
229 3VS 0.9055
230 0FO 0.9054
231 HNT 0.9053
232 2HC 0.9053
233 BK9 0.9049
234 0BP 0.9049
235 209 0.9047
236 AMR 0.9041
237 FF2 0.9041
238 5QY 0.9038
239 DNC 0.9038
240 3PF 0.9032
241 EMO 0.9032
242 QMS 0.9031
243 2O6 0.9031
244 7MX 0.9031
245 J5I 0.9031
246 EVF 0.9030
247 AJV 0.9030
248 8WO 0.9029
249 NDG 0.9026
250 NID 0.9026
251 9FE 0.9026
252 XAZ 0.9024
253 QIV 0.9023
254 MQN 0.9020
255 M1Q 0.9020
256 LUM 0.9019
257 3AE 0.9019
258 DNF 0.9017
259 5NS 0.9017
260 PMP 0.9017
261 LEL 0.9015
262 BNL 0.9015
263 INE 0.9014
264 G3E 0.9014
265 ONR 0.9014
266 EV2 0.9013
267 4HB 0.9012
268 CX6 0.9011
269 SE2 0.9008
270 2QC 0.9006
271 LZ2 0.9006
272 M78 0.9006
273 UNJ 0.9005
274 WS7 0.9005
275 1DR 0.9002
276 ZEC 0.9001
277 M2K 0.9001
278 PLP 0.9001
279 52C 0.8999
280 I6G 0.8997
281 4AA 0.8996
282 AY4 0.8993
283 DX3 0.8992
284 S8A 0.8991
285 582 0.8991
286 ST1 0.8991
287 RXA 0.8989
288 IOS 0.8989
289 535 0.8988
290 E3X 0.8987
291 M6N 0.8986
292 MAJ 0.8985
293 BZE 0.8985
294 GLC 0.8984
295 A5E 0.8984
296 39O 0.8982
297 3VQ 0.8980
298 DNQ 0.8980
299 5GV 0.8980
300 PNZ 0.8979
301 NQ 0.8979
302 2J1 0.8978
303 4HC 0.8977
304 5RN 0.8976
305 B21 0.8976
306 A5H 0.8975
307 5F5 0.8975
308 K7H 0.8975
309 BEA 0.8975
310 0TU 0.8975
311 CSN 0.8971
312 4MU 0.8969
313 MSR 0.8969
314 0XT 0.8968
315 SNU 0.8965
316 J9W 0.8965
317 UFO 0.8964
318 TTY 0.8963
319 4YO 0.8963
320 6FZ 0.8961
321 FLV 0.8959
322 MEW 0.8956
323 GNJ 0.8955
324 RNO 0.8955
325 61M 0.8954
326 Y3L 0.8952
327 ROI 0.8951
328 J6W 0.8951
329 78Y 0.8951
330 AQO 0.8949
331 PRZ 0.8948
332 URC 0.8945
333 BZQ 0.8944
334 5LA 0.8944
335 SYA 0.8944
336 8W9 0.8944
337 E7S 0.8943
338 OW7 0.8942
339 TZF 0.8942
340 L22 0.8942
341 FBF 0.8940
342 RD4 0.8939
343 F2W 0.8939
344 AJ2 0.8939
345 OA1 0.8937
346 7O4 0.8935
347 VM1 0.8935
348 NLA 0.8934
349 IQ5 0.8934
350 DX7 0.8933
351 3Y7 0.8931
352 428 0.8931
353 LR5 0.8931
354 XI7 0.8930
355 F4E 0.8930
356 GDL 0.8928
357 Q24 0.8928
358 ANN 0.8927
359 PHH 0.8926
360 TTL 0.8926
361 BBK 0.8924
362 JCZ 0.8923
363 GNY 0.8922
364 TGX 0.8921
365 5JQ 0.8921
366 1FE 0.8920
367 H33 0.8920
368 QPR 0.8920
369 DDU 0.8920
370 4NZ 0.8920
371 QQQ 0.8917
372 22L 0.8916
373 M5K 0.8915
374 JF1 0.8914
375 XM5 0.8910
376 EA1 0.8910
377 226 0.8910
378 6RQ 0.8909
379 QBK 0.8909
380 7W1 0.8909
381 8D6 0.8908
382 2AK 0.8908
383 KW8 0.8907
384 657 0.8905
385 WS6 0.8904
386 KJU 0.8904
387 PUE 0.8904
388 MNY 0.8903
389 WV7 0.8903
390 PD2 0.8902
391 CTS 0.8902
392 4BZ 0.8900
393 A2G 0.8900
394 IV2 0.8899
395 JWS 0.8899
396 0SY 0.8899
397 F4K 0.8898
398 7B3 0.8898
399 K32 0.8897
400 2P3 0.8897
401 PE0 0.8896
402 A29 0.8895
403 SKA 0.8895
404 PPY 0.8893
405 2PK 0.8893
406 2PV 0.8893
407 SG2 0.8892
408 PDC 0.8892
409 KTJ 0.8890
410 E5X 0.8890
411 5GU 0.8888
412 TWO 0.8887
413 CPZ 0.8887
414 75K 0.8886
415 5NE 0.8886
416 Q0K 0.8886
417 VC3 0.8885
418 JY4 0.8885
419 ZYQ 0.8885
420 MPV 0.8884
421 GVY 0.8884
422 JBZ 0.8884
423 IBM 0.8882
424 NGA 0.8882
425 ODK 0.8882
426 37T 0.8881
427 BZ3 0.8880
428 MXD 0.8879
429 BHQ 0.8878
430 G14 0.8877
431 F31 0.8877
432 HX4 0.8877
433 AM4 0.8877
434 FZM 0.8876
435 RSV 0.8875
436 PQ0 0.8874
437 F40 0.8872
438 MPK 0.8871
439 LFQ 0.8871
440 4LW 0.8871
441 UAN 0.8870
442 EWG 0.8869
443 92K 0.8868
444 GZL 0.8866
445 0GZ 0.8866
446 HQT 0.8865
447 AZ8 0.8865
448 5WY 0.8865
449 EAE 0.8865
450 JU2 0.8864
451 7I2 0.8862
452 GZ2 0.8862
453 0UL 0.8862
454 3VW 0.8861
455 ZRK 0.8860
456 8G0 0.8860
457 PQK 0.8858
458 6ZW 0.8858
459 39Z 0.8858
460 PYQ 0.8856
461 ES5 0.8855
462 DXK 0.8855
463 YZ9 0.8852
464 4ME 0.8852
465 5F8 0.8851
466 YE6 0.8851
467 S7J 0.8851
468 KJH 0.8850
469 5OB 0.8850
470 SJK 0.8849
471 ENO 0.8849
472 2BG 0.8848
473 7ME 0.8846
474 S98 0.8845
475 HLD 0.8844
476 1Z6 0.8844
477 F5C 0.8843
478 ALE 0.8843
479 X0W 0.8842
480 MUR 0.8842
481 2WU 0.8841
482 EXD 0.8841
483 WSD 0.8841
484 N3W 0.8841
485 36E 0.8840
486 5QX 0.8840
487 IOP 0.8839
488 4CM 0.8835
489 795 0.8834
490 7ZE 0.8833
491 9CE 0.8832
492 BTY 0.8831
493 5XC 0.8831
494 JTH 0.8830
495 OTA 0.8829
496 K22 0.8827
497 12Q 0.8827
498 4V2 0.8827
499 6TZ 0.8826
500 JRO 0.8825
501 03V 0.8824
502 YE7 0.8823
503 OCH 0.8822
504 8TX 0.8821
505 OCZ 0.8820
506 K25 0.8820
507 SRO 0.8820
508 27M 0.8819
509 67X 0.8818
510 KYN 0.8817
511 4Z4 0.8817
512 SYV 0.8817
513 BDP 0.8816
514 2AQ 0.8815
515 FHC 0.8814
516 HQJ 0.8814
517 TSS 0.8814
518 64C 0.8813
519 4FS 0.8812
520 2JX 0.8812
521 VNL 0.8812
522 P4L 0.8811
523 4WL 0.8810
524 KP2 0.8810
525 P0P 0.8809
526 DRL 0.8808
527 MOK 0.8808
528 2F6 0.8807
529 JF2 0.8806
530 Q71 0.8806
531 9BF 0.8806
532 J38 0.8806
533 GAL 0.8805
534 K3Q 0.8804
535 2ZQ 0.8803
536 L46 0.8801
537 QBP 0.8801
538 GHM 0.8799
539 C53 0.8799
540 FUD 0.8796
541 XIY 0.8796
542 DOB 0.8796
543 5AD 0.8796
544 L1T 0.8796
545 2HQ 0.8794
546 FA0 0.8794
547 MUA 0.8793
548 ZME 0.8793
549 549 0.8792
550 5JL 0.8792
551 6X9 0.8791
552 L07 0.8791
553 NDH 0.8791
554 OA3 0.8790
555 PIQ 0.8789
556 IWT 0.8789
557 CFF 0.8787
558 CHQ 0.8787
559 CTL 0.8787
560 AJ1 0.8786
561 K68 0.8786
562 5CU 0.8785
563 R9Y 0.8785
564 M3E 0.8785
565 4NP 0.8784
566 ES2 0.8781
567 7FU 0.8780
568 NDD 0.8780
569 R20 0.8780
570 7WR 0.8778
571 QX2 0.8777
572 MS0 0.8776
573 2D2 0.8775
574 CLW 0.8775
575 KGK 0.8775
576 MHK 0.8774
577 OPA 0.8774
578 H42 0.8773
579 B57 0.8773
580 D3G 0.8772
581 E3D 0.8772
582 APZ 0.8772
583 4MB 0.8771
584 36Y 0.8771
585 B55 0.8770
586 XFE 0.8770
587 4M0 0.8769
588 8NB 0.8769
589 K2T 0.8769
590 B52 0.8768
591 DPZ 0.8768
592 N2Z 0.8767
593 MRW 0.8766
594 VXX 0.8764
595 BHA 0.8764
596 QWW 0.8764
597 4AN 0.8763