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Receptor
PDB id Resolution Class Description Source Keywords
4BBX 2.5 Å EC: 3.1.4.17 DISCOVERY OF A POTENT, SELECTIVE AND ORALLY ACTIVE PDE10A INHIBITOR FOR THE TREATMENT OF SCHIZOPHRENIA HOMO SAPIENS PHOSPHODIESTERASE INHIBITOR INHIBITOR COMPLEX HYDROLASE ZBINDING MAGNESIUM BINDING
Ref.: DISCOVERY OF A POTENT, SELECTIVE AND ORALLY ACTIVE INHIBITOR FOR THE POTENTIAL TREATMENT OF SCHIZOPHRE J.MED.CHEM. V. 57 4196 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
LKF A:1760;
B:1760;
Valid;
Valid;
none;
none;
ic50 = 60 nM
356.422 C18 H24 N6 O2 Cc1c(...
ZN B:1761;
A:1761;
Part of Protein;
Part of Protein;
none;
none;
submit data
65.409 Zn [Zn+2...
MG B:1762;
A:1762;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5C2H 2.09 Å EC: 3.1.4.17 PDE10 COMPLEXED WITH 6-CHLORO-N-[(2,4-DIMETHYLTHIAZOL-5-YL)M METHYL-2-[3-(2-QUINOLYL)PROPOXY]PYRIMIDIN-4-AMINE HOMO SAPIENS PHOSPHODIESTERASE INHIBITOR COMPLEX HYDROLASE-HYDROLASE ICOMPLEX
Ref.: DISCOVERY AND OPTIMIZATION OF A SERIES OF PYRIMIDIN PHOSPHODIESTERASE 10A (PDE10A) INHIBITORS THROUGH F SCREENING, STRUCTURE-BASED DESIGN, AND PARALLEL SYN J.MED.CHEM. V. 58 7888 2015
Members (63)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 19 families.
1 5I2R ic50 = 0.019 uM 67A C20 H13 F3 N4 O2 c1ccc(cc1)....
2 4FCB ic50 = 2.9 nM 0T7 C25 H24 N4 O CCCc1nc(c2....
3 4LM3 Ki = 1200 uM 9ZE C10 H10 O3 CC(=O)c1cc....
4 5C29 Ki = 880 nM 4XY C11 H16 Cl N3 CCCNc1c(c(....
5 4MSC Ki = 1.1 uM 2ZT C19 H14 N2 O c1ccc2c(c1....
6 2OUQ - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
7 4MRW Ki = 500 uM MRW C9 H6 Cl N O c1cc2c(ccn....
8 5C2E Ki = 590 nM 4Y1 C18 H20 Cl N5 O S Cc1c(nc(nc....
9 4LKQ Ki = 450 uM 1XM C5 H5 N5 S c1c2c([nH]....
10 3LXG ic50 = 7.28 nM Z73 C15 H18 N4 O CCCc1nc(c2....
11 5AXP ic50 = 0.94 nM 4LK C23 H18 F N5 O4 COC1=CN(N=....
12 4ZO5 Ki = 0.15 nM 4Q0 C28 H25 N3 O5 CC(C)Oc1cc....
13 5C1W Ki = 8.7 uM 4XS C8 H8 Cl2 N2 Cc1c(nc(nc....
14 3UI7 Ki = 1 nM C1L C18 H22 N4 O2 Cc1cc(cc2c....
15 2OUY - CMP C10 H12 N5 O6 P c1nc(c2c(n....
16 3SNL ic50 = 0.7 nM 548 C19 H14 Cl F3 N4 Cc1cnccc1c....
17 4LM4 Ki = 910 uM JPZ C8 H6 N2 O c1ccc2c(c1....
18 2OUN - AMP C10 H14 N5 O7 P c1nc(c2c(n....
19 5EDI ic50 = 0.3 nM 5M9 C17 H22 Cl N7 Cc1cc(c(n2....
20 2OUR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
21 2Y0J ic50 = 12 nM AXC C18 H14 N6 S Cc1nc2c3cc....
22 4FCD ic50 = 0.28 nM 0T6 C18 H15 Cl N4 O2 Cc1c2nnc3c....
23 5B4L ic50 = 0.76 nM 6DW C28 H27 N7 O2 c1ccc(cc1)....
24 5C2H Ki = 0.0082 nM 4XU C23 H24 Cl N5 O S Cc1c(nc(nc....
25 4YS7 ic50 = 0.001 uM 4GK C20 H19 N7 Cc1cnc(c2n....
26 5EDH - 5MF C17 H24 N8 CCc1cnc(n2....
27 4PHW ic50 = 0.1 nM 2W1 C24 H21 N3 O3 c1ccc2c(c1....
28 4BBX ic50 = 60 nM LKF C18 H24 N6 O2 Cc1c(n2ccn....
29 5DH5 Ki = 0.23 nM 5AY C20 H21 N7 O Cn1cc(cn1)....
30 4P1R ic50 = 4.1 nM 2KR C19 H17 N5 O Cc1ccc(nc1....
31 4LLP Ki = 450 uM 4ZE C7 H9 N O Cc1cc(ccc1....
32 5UWF ic50 = 0.059 uM 8Q7 C22 H19 F2 N5 O3 S COc1ccc(cc....
33 4MSH Ki = 210 uM 2D0 C7 H5 Cl N2 S c1cc2c(c(c....
34 5AXQ ic50 = 0.08 uM 4LP C28 H26 F N5 O3 CC1(c2c(cc....
35 4LM2 Ki = 940 uM 8ZE C9 H10 O3 c1cc2c(cc1....
36 4YQH ic50 = 0.009 uM 4F7 C19 H16 N4 c1ccc(cc1)....
37 5C2A Ki = 4.8 nM 4Y2 C14 H17 Cl N4 S Cc1c(nc(nc....
38 4DDL ic50 = 4.9 nM 0JQ C24 H30 N4 O3 Cc1cc(cnc1....
39 4P0N ic50 = 3.4 nM 1IR C18 H17 N5 O S COc1nc2ccc....
40 5EDG - 5MG C20 H12 Cl F3 N4 O2 c1ccc(cc1)....
41 4LLX Ki = 1300 uM 5ZE C6 H9 N3 Cc1cc(nc(n....
42 5C28 Ki = 2.2 uM 4XV C8 H10 Cl N3 Cc1c(nc(nc....
43 2OUU - 35G C10 H12 N5 O7 P c1nc2c(n1[....
44 4MVH ic50 = 4.5 nM 2F5 C22 H19 N5 O3 c1ccc2c(c1....
45 4HEU ic50 = 0.097 nM 15J C24 H25 N5 O2 c1ccc2c(c1....
46 4LLJ Ki = 380 uM 1XN C8 H9 N3 c1ccc2c(c1....
47 3SNI ic50 = 11 nM 546 C18 H17 N5 O Cc1ccncc1c....
48 4HF4 ic50 = 2.4 nM 15H C24 H25 N5 O2 S C[C@@H](C1....
49 3SN7 ic50 = 0.7 nM 540 C19 H17 F N4 O Cc1cnccc1c....
50 4AEL ic50 = 12 nM 4HN C23 H17 N3 O2 CCOc1ccccc....
51 4LLK Ki = 990 uM MEW C9 H8 N2 O CC1=Nc2ccc....
52 4MSA Ki = 500 uM 2ZM C7 H5 N3 O2 c1cc2c(cc1....
53 4MS0 Ki = 410 uM 2ZX C4 H5 Cl N4 c1c(nc(nc1....
54 4LM0 Ki = 560 uM 5NI C7 H5 N3 O2 c1cc2c(cc1....
55 4DFF Ki = 35 nM 0JP C16 H15 N3 O2 S COc1cc2c(c....
56 3WI2 ic50 = 601 nM P98 C26 H23 N3 O CC(C)c1nc2....
57 4MRZ Ki = 300 uM 2ZV C6 H7 N3 O2 Cc1ccnc(c1....
58 4LM1 Ki = 590 uM 7ZE C9 H6 N2 O2 c1cc2c(ccc....
59 5DH4 Ki = 58 nM 5AV C12 H12 Cl N5 S Cc1c(sc(n1....
60 5XUJ - 8G6 C13 H10 Cl N3 Cc1cc2nccc....
61 3UUO Ki = 11 nM 0CV C17 H21 N5 O Cc1cc(cc2c....
62 4MSN Ki = 94 uM 2ZQ C9 H6 N2 O2 c1cc2cccnc....
63 4XY2 ic50 = 8 nM 490 C25 H23 N5 O2 Cn1cc(c(n1....
70% Homology Family (73)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 14 families.
1 5I2R ic50 = 0.019 uM 67A C20 H13 F3 N4 O2 c1ccc(cc1)....
2 4FCB ic50 = 2.9 nM 0T7 C25 H24 N4 O CCCc1nc(c2....
3 4LM3 Ki = 1200 uM 9ZE C10 H10 O3 CC(=O)c1cc....
4 5C29 Ki = 880 nM 4XY C11 H16 Cl N3 CCCNc1c(c(....
5 4MSC Ki = 1.1 uM 2ZT C19 H14 N2 O c1ccc2c(c1....
6 2OUQ - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
7 4MRW Ki = 500 uM MRW C9 H6 Cl N O c1cc2c(ccn....
8 5C2E Ki = 590 nM 4Y1 C18 H20 Cl N5 O S Cc1c(nc(nc....
9 4LKQ Ki = 450 uM 1XM C5 H5 N5 S c1c2c([nH]....
10 3LXG ic50 = 7.28 nM Z73 C15 H18 N4 O CCCc1nc(c2....
11 5AXP ic50 = 0.94 nM 4LK C23 H18 F N5 O4 COC1=CN(N=....
12 4ZO5 Ki = 0.15 nM 4Q0 C28 H25 N3 O5 CC(C)Oc1cc....
13 5C1W Ki = 8.7 uM 4XS C8 H8 Cl2 N2 Cc1c(nc(nc....
14 3UI7 Ki = 1 nM C1L C18 H22 N4 O2 Cc1cc(cc2c....
15 2OUY - CMP C10 H12 N5 O6 P c1nc(c2c(n....
16 3SNL ic50 = 0.7 nM 548 C19 H14 Cl F3 N4 Cc1cnccc1c....
17 4LM4 Ki = 910 uM JPZ C8 H6 N2 O c1ccc2c(c1....
18 2OUN - AMP C10 H14 N5 O7 P c1nc(c2c(n....
19 5EDI ic50 = 0.3 nM 5M9 C17 H22 Cl N7 Cc1cc(c(n2....
20 2OUR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
21 2Y0J ic50 = 12 nM AXC C18 H14 N6 S Cc1nc2c3cc....
22 4FCD ic50 = 0.28 nM 0T6 C18 H15 Cl N4 O2 Cc1c2nnc3c....
23 5B4L ic50 = 0.76 nM 6DW C28 H27 N7 O2 c1ccc(cc1)....
24 5C2H Ki = 0.0082 nM 4XU C23 H24 Cl N5 O S Cc1c(nc(nc....
25 4YS7 ic50 = 0.001 uM 4GK C20 H19 N7 Cc1cnc(c2n....
26 5EDH - 5MF C17 H24 N8 CCc1cnc(n2....
27 4PHW ic50 = 0.1 nM 2W1 C24 H21 N3 O3 c1ccc2c(c1....
28 4BBX ic50 = 60 nM LKF C18 H24 N6 O2 Cc1c(n2ccn....
29 5DH5 Ki = 0.23 nM 5AY C20 H21 N7 O Cn1cc(cn1)....
30 4P1R ic50 = 4.1 nM 2KR C19 H17 N5 O Cc1ccc(nc1....
31 4LLP Ki = 450 uM 4ZE C7 H9 N O Cc1cc(ccc1....
32 5UWF ic50 = 0.059 uM 8Q7 C22 H19 F2 N5 O3 S COc1ccc(cc....
33 4MSH Ki = 210 uM 2D0 C7 H5 Cl N2 S c1cc2c(c(c....
34 5AXQ ic50 = 0.08 uM 4LP C28 H26 F N5 O3 CC1(c2c(cc....
35 4LM2 Ki = 940 uM 8ZE C9 H10 O3 c1cc2c(cc1....
36 4YQH ic50 = 0.009 uM 4F7 C19 H16 N4 c1ccc(cc1)....
37 5C2A Ki = 4.8 nM 4Y2 C14 H17 Cl N4 S Cc1c(nc(nc....
38 4DDL ic50 = 4.9 nM 0JQ C24 H30 N4 O3 Cc1cc(cnc1....
39 4P0N ic50 = 3.4 nM 1IR C18 H17 N5 O S COc1nc2ccc....
40 5EDG - 5MG C20 H12 Cl F3 N4 O2 c1ccc(cc1)....
41 4LLX Ki = 1300 uM 5ZE C6 H9 N3 Cc1cc(nc(n....
42 5C28 Ki = 2.2 uM 4XV C8 H10 Cl N3 Cc1c(nc(nc....
43 2OUU - 35G C10 H12 N5 O7 P c1nc2c(n1[....
44 4MVH ic50 = 4.5 nM 2F5 C22 H19 N5 O3 c1ccc2c(c1....
45 4HEU ic50 = 0.097 nM 15J C24 H25 N5 O2 c1ccc2c(c1....
46 4LLJ Ki = 380 uM 1XN C8 H9 N3 c1ccc2c(c1....
47 3SNI ic50 = 11 nM 546 C18 H17 N5 O Cc1ccncc1c....
48 4HF4 ic50 = 2.4 nM 15H C24 H25 N5 O2 S C[C@@H](C1....
49 3SN7 ic50 = 0.7 nM 540 C19 H17 F N4 O Cc1cnccc1c....
50 4AEL ic50 = 12 nM 4HN C23 H17 N3 O2 CCOc1ccccc....
51 4LLK Ki = 990 uM MEW C9 H8 N2 O CC1=Nc2ccc....
52 4MSA Ki = 500 uM 2ZM C7 H5 N3 O2 c1cc2c(cc1....
53 4MS0 Ki = 410 uM 2ZX C4 H5 Cl N4 c1c(nc(nc1....
54 4LM0 Ki = 560 uM 5NI C7 H5 N3 O2 c1cc2c(cc1....
55 4DFF Ki = 35 nM 0JP C16 H15 N3 O2 S COc1cc2c(c....
56 3WI2 ic50 = 601 nM P98 C26 H23 N3 O CC(C)c1nc2....
57 4MRZ Ki = 300 uM 2ZV C6 H7 N3 O2 Cc1ccnc(c1....
58 4LM1 Ki = 590 uM 7ZE C9 H6 N2 O2 c1cc2c(ccc....
59 5DH4 Ki = 58 nM 5AV C12 H12 Cl N5 S Cc1c(sc(n1....
60 5XUJ - 8G6 C13 H10 Cl N3 Cc1cc2nccc....
61 3UUO Ki = 11 nM 0CV C17 H21 N5 O Cc1cc(cc2c....
62 4MSN Ki = 94 uM 2ZQ C9 H6 N2 O2 c1cc2cccnc....
63 4XY2 ic50 = 8 nM 490 C25 H23 N5 O2 Cn1cc(c(n1....
64 3HQW ic50 = 51 nM PF4 C21 H18 N2 O2 S COc1ccc(cc....
65 3QPO ic50 = 247 nM PFR C27 H28 N4 O2 COc1cc2c(c....
66 2OVV Kd = 12 nM PFH C24 H23 N3 O3 COc1cc2c(c....
67 3HR1 ic50 = 0.37 nM PF9 C25 H20 N4 O Cn1cc(c(n1....
68 3QPN ic50 = 17 nM PFK C20 H17 N3 O2 COc1cc2cnc....
69 3HQZ ic50 = 0.42 nM PF8 C24 H18 N4 O c1ccc2c(c1....
70 2O8H Ki = 25 nM 227 C24 H29 N5 O4 S CN1CCN(CC1....
71 3HQY ic50 = 11.5 nM PF6 C25 H20 N4 O c1ccc2c(c1....
72 2OVY Ki = 4 nM PFJ C22 H21 N5 O3 COc1cc2c(c....
73 3QPP ic50 = 12 nM PFW C31 H30 N4 O2 COc1cc2c(c....
50% Homology Family (205)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2CHM ic50 = 5.5 nM 3P4 C23 H29 N6 O3 CCc1c2c([n....
2 3TGG - 0H3 C23 H31 N5 O4 CCCOCCN1c2....
3 3HDZ ic50 = 51 nM PD6 C18 H19 N3 O CCCCN1C=CC....
4 3TGE ic50 = 0.07 nM TGE C24 H32 N6 O4 CCCOCCN1c2....
5 3B2R - VDN C23 H32 N6 O4 S CCCc1nc(c2....
6 2H44 ic50 = 1.7 uM 7CA C27 H32 O10 C[C@H]1[C@....
7 2H42 ic50 = 2.4 nM VIA C22 H30 N6 O4 S CCCc1c2c(n....
8 1T9S - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
9 4MD6 ic50 = 17 nM 24E C22 H15 N O3 S c1ccc2c(c1....
10 1UHO Kd ~ 0.6 nM VDN C23 H32 N6 O4 S CCCc1nc(c2....
11 1UDT Kd ~ 0.5 nM VIA C22 H30 N6 O4 S CCCc1c2c(n....
12 1RKP - IBM C10 H14 N4 O2 CC(C)CN1c2....
13 4IA0 ic50 = 77 nM 5BB C25 H37 Br N4 O4 S CCCCCCCCC1....
14 3SIE ic50 = 13.3 nM 5BO C20 H27 Br N4 O4 S CCCOc1ccc(....
15 3HC8 ic50 = 2.9 nM PD4 C24 H32 N6 O4 CCCOCCN1c2....
16 1XP0 ic50 = 0.001 uM VDN C23 H32 N6 O4 S CCCc1nc(c2....
17 1XOZ ic50 = 0.0012 uM CIA C22 H19 N3 O4 CN1CC(=O)N....
18 4I9Z ic50 = 18.2 nM 5BA C23 H31 Br N4 O3 CCCOc1ccc(....
19 1TBF - VIA C22 H30 N6 O4 S CCCc1c2c(n....
20 4OEX Kd = 0.00000145 M 5EO C20 H28 N4 O4 S CCCOc1ccc(....
21 4G2Y ic50 = 1.6 nM NI5 C21 H28 N4 O4 S CCCOc1ccc(....
22 4OEW Kd = 0.00000145 M 5IO C20 H27 I N4 O4 S CCCOc1ccc(....
23 1Y2B ic50 = 82 uM DEE C8 H12 N2 O2 CCOC(=O)c1....
24 1TBB - ROL C16 H21 N O3 COc1ccc(cc....
25 4W1O - 3GJ C19 H17 Cl2 N3 O4 CCc1cc(on1....
26 5LBO - 6M5 C33 H40 N6 O4 COc1ccc(cc....
27 1ZKN - IBM C10 H14 N4 O2 CC(C)CN1c2....
28 3SL4 ic50 = 0.027 uM JN4 C21 H21 N3 O4 S C=CNC(=O)N....
29 1XOQ ic50 = 0.68 nM ROF C17 H14 Cl2 F2 N2 O3 c1cc(c(cc1....
30 1Y2E ic50 = 0.16 uM 5DE C14 H17 N3 O2 CCOC(=O)c1....
31 1PTW - AMP C10 H14 N5 O7 P c1nc(c2c(n....
32 5WQA ic50 = 0.011 uM J20 C36 H26 O5 COc1ccc(cc....
33 1Y2D ic50 = 2 uM 4DE C15 H18 N2 O3 CCOC(=O)c1....
34 6F8W ic50 = 23 uM D0E C22 H29 N3 O4 COc1ccc(cc....
35 1XON ic50 = 0.021 nM PIL C18 H18 Cl2 N2 O3 COc1ccc(cc....
36 1TB7 - AMP C10 H14 N5 O7 P c1nc(c2c(n....
37 6FDC ic50 = 2.3 uM DD5 C22 H29 F2 N3 O4 c1cc(c(cc1....
38 1XOR ic50 = 0.39 uM ZAR C12 H10 F2 N2 O3 COc1cc(ccc....
39 3G4K ic50 = 288 nM ROL C16 H21 N O3 COc1ccc(cc....
40 1Y2C ic50 = 0.27 uM 3DE C14 H17 N2 O2 CCOC(=O)c1....
41 2FM0 ic50 = 0.4 nM M98 C23 H18 F8 N2 O4 S c1cc(c[n+]....
42 6F8T ic50 = 7 uM CZT C22 H34 N2 O5 C[C@@H]1CN....
43 1Y2K ic50 = 0.021 uM 7DE C14 H15 N3 O4 CCOC(=O)c1....
44 1XOM ic50 = 0.011 uM CIO C20 H25 N O4 COc1ccc(cc....
45 2PW3 - CMP C10 H12 N5 O6 P c1nc(c2c(n....
46 1Q9M ic50 = 0.33 uM ROL C16 H21 N O3 COc1ccc(cc....
47 4WCU ic50 = 3 nM 3KQ C24 H22 Cl2 N2 O5 COc1ccc(c(....
48 6F8U ic50 = 0.8 uM CZQ C21 H28 F2 N2 O5 C[C@@H]1CN....
49 2FM5 ic50 = 43 nM M99 C23 H18 F8 N2 O4 S c1cc(c[n+]....
50 3G4I - D71 C19 H13 N5 O4 c1cc(cc(c1....
51 6F6U ic50 = 16 uM CV8 C21 H30 N2 O5 C[C@@H]1CN....
52 6F8V ic50 = 16 uM D0B C24 H33 N3 O4 C[C@@H]1CN....
53 3G4L ic50 = 5.8 nM ROF C17 H14 Cl2 F2 N2 O3 c1cc(c(cc1....
54 4G2J ic50 = 14 nM 0WF C21 H25 N5 O2 C[C@H](C1=....
55 3K3H - BYE C15 H12 Cl F3 N4 O C[C@@H](CC....
56 3DY8 - IBM C10 H14 N4 O2 CC(C)CN1c2....
57 3DYN - PCG C10 H12 N5 O7 P c1nc2c(n1[....
58 3DYQ - PCG C10 H12 N5 O7 P c1nc2c(n1[....
59 3JSW ic50 = 66 nM JAR C20 H25 N5 O C[C@@H]1C[....
60 3DYS - IBM C10 H14 N4 O2 CC(C)CN1c2....
61 4E90 ic50 = 8 nM 7RG C20 H25 N7 O2 C[C@@H]1C[....
62 5U7K ic50 = 7.1 nM 7Y1 C20 H22 N6 O CCCOc1cncc....
63 6CYD ic50 = 2 nM FKG C16 H15 F3 N4 O2 CC1=Nc2c(c....
64 5TZA ic50 = 0.001 uM 7OG C22 H21 N5 O Cc1cc(n2c(....
65 6C7G ic50 = 0.00000001 M EOY C31 H34 Cl N5 O2 Cc1c2nnc(n....
66 5VP0 ic50 = 0.61 nM 9GJ C19 H18 F4 N4 O5 COC[C@H](c....
67 5U00 Kd = 0.002 uM 7OV C18 H15 F3 I N5 O Cc1cc(n2c(....
68 5U7I ic50 = 66.6 nM 7XS C20 H25 N5 O2 CC(C)Cc1c2....
69 5U7J ic50 = 389.6 nM 7XV C18 H22 N4 O2 CC(C)Cc1nn....
70 5XKM ic50 = 24 nM 87R C18 H17 F3 N4 O2 CC[C@H](c1....
71 6B98 Ki = 22.4 uM D07 C7 H8 Cl N5 CNc1c2cnn(....
72 6B96 Ki = 14.3 nM CZV C15 H11 Cl F3 N5 c1cc(ccc1C....
73 5U7D ic50 = 0.5 nM 19F C27 H32 N4 O4 Cc1c2n(c(n....
74 5TZX ic50 = 0.052 uM 7OY C18 H15 Cl F3 N5 O Cc1cc(n2c(....
75 6C7I ic50 = 0.00000001 M EP7 C22 H22 Cl N5 O2 Cc1c2nnc(n....
76 6CYB ic50 = 0.96 nM FKV C16 H12 F6 N4 O2 C[C@@H](c1....
77 6B97 Ki = 0.237 uM CZY C15 H13 Cl F3 N5 C[C@H](c1c....
78 5TZZ ic50 = 0.008 uM 7OJ C18 H15 Br F3 N5 O Cc1cc(n2c(....
79 5VP1 ic50 = 51 nM 9GA C22 H22 F3 N7 O3 Cc1cn2c(c(....
80 4HTX ic50 = 4.7 nM 19F C27 H32 N4 O4 Cc1c2n(c(n....
81 6EZF - C6Z C11 H8 Cl2 N2 S c1cc(c(cc1....
82 5TZ3 ic50 = 0.14 uM 7OM C22 H22 N6 O Cc1cc(n2c(....
83 5TZH ic50 = 0.679 uM 7OP C18 H16 F3 N5 O Cc1cc(n2c(....
84 5TZC ic50 = 0.008 uM 7OJ C18 H15 Br F3 N5 O Cc1cc(n2c(....
85 3ITU ic50 = 40 uM IBM C10 H14 N4 O2 CC(C)CN1c2....
86 6C7F ic50 = 0.00000001 M EOS C22 H22 Cl N5 O2 Cc1c2nnc(n....
87 6C7E ic50 = 0.00000001 M EOG C18 H14 Cl N5 O Cc1c2nnc(n....
88 6C7J ic50 = 0.00000001 M EPV C25 H28 Cl N5 O2 Cc1c2nnc(n....
89 4JIB ic50 = 45 nM 1L6 C23 H28 N6 O2 CCC(C)(C)c....
90 5U7L ic50 = 4.9 nM 7Y4 C24 H30 N8 CCc1ccc(cc....
91 4D09 ic50 = 1.7 nM 788 C24 H19 N5 O Cc1c2nnc(n....
92 6C7D ic50 = 0.00000001 M EOJ C27 H26 Cl N5 O Cc1c2nnc(n....
93 5TZW ic50 = 0.987 uM 7P4 C18 H15 F4 N5 O Cc1cc(n2c(....
94 6CYC ic50 = 14 nM FKJ C15 H13 F3 N4 O3 C[C@@H](c1....
95 4D08 ic50 = 10 nM Q2T C24 H28 N6 O2 CCCCOc1cc(....
96 5I2R ic50 = 0.019 uM 67A C20 H13 F3 N4 O2 c1ccc(cc1)....
97 4FCB ic50 = 2.9 nM 0T7 C25 H24 N4 O CCCc1nc(c2....
98 4LM3 Ki = 1200 uM 9ZE C10 H10 O3 CC(=O)c1cc....
99 5C29 Ki = 880 nM 4XY C11 H16 Cl N3 CCCNc1c(c(....
100 4MSC Ki = 1.1 uM 2ZT C19 H14 N2 O c1ccc2c(c1....
101 2OUQ - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
102 4MRW Ki = 500 uM MRW C9 H6 Cl N O c1cc2c(ccn....
103 5C2E Ki = 590 nM 4Y1 C18 H20 Cl N5 O S Cc1c(nc(nc....
104 4LKQ Ki = 450 uM 1XM C5 H5 N5 S c1c2c([nH]....
105 3LXG ic50 = 7.28 nM Z73 C15 H18 N4 O CCCc1nc(c2....
106 5AXP ic50 = 0.94 nM 4LK C23 H18 F N5 O4 COC1=CN(N=....
107 4ZO5 Ki = 0.15 nM 4Q0 C28 H25 N3 O5 CC(C)Oc1cc....
108 5C1W Ki = 8.7 uM 4XS C8 H8 Cl2 N2 Cc1c(nc(nc....
109 3UI7 Ki = 1 nM C1L C18 H22 N4 O2 Cc1cc(cc2c....
110 2OUY - CMP C10 H12 N5 O6 P c1nc(c2c(n....
111 3SNL ic50 = 0.7 nM 548 C19 H14 Cl F3 N4 Cc1cnccc1c....
112 4LM4 Ki = 910 uM JPZ C8 H6 N2 O c1ccc2c(c1....
113 2OUN - AMP C10 H14 N5 O7 P c1nc(c2c(n....
114 5EDI ic50 = 0.3 nM 5M9 C17 H22 Cl N7 Cc1cc(c(n2....
115 2OUR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
116 2Y0J ic50 = 12 nM AXC C18 H14 N6 S Cc1nc2c3cc....
117 4FCD ic50 = 0.28 nM 0T6 C18 H15 Cl N4 O2 Cc1c2nnc3c....
118 5B4L ic50 = 0.76 nM 6DW C28 H27 N7 O2 c1ccc(cc1)....
119 5C2H Ki = 0.0082 nM 4XU C23 H24 Cl N5 O S Cc1c(nc(nc....
120 4YS7 ic50 = 0.001 uM 4GK C20 H19 N7 Cc1cnc(c2n....
121 5EDH - 5MF C17 H24 N8 CCc1cnc(n2....
122 4PHW ic50 = 0.1 nM 2W1 C24 H21 N3 O3 c1ccc2c(c1....
123 4BBX ic50 = 60 nM LKF C18 H24 N6 O2 Cc1c(n2ccn....
124 5DH5 Ki = 0.23 nM 5AY C20 H21 N7 O Cn1cc(cn1)....
125 4P1R ic50 = 4.1 nM 2KR C19 H17 N5 O Cc1ccc(nc1....
126 4LLP Ki = 450 uM 4ZE C7 H9 N O Cc1cc(ccc1....
127 5UWF ic50 = 0.059 uM 8Q7 C22 H19 F2 N5 O3 S COc1ccc(cc....
128 4MSH Ki = 210 uM 2D0 C7 H5 Cl N2 S c1cc2c(c(c....
129 5AXQ ic50 = 0.08 uM 4LP C28 H26 F N5 O3 CC1(c2c(cc....
130 4LM2 Ki = 940 uM 8ZE C9 H10 O3 c1cc2c(cc1....
131 4YQH ic50 = 0.009 uM 4F7 C19 H16 N4 c1ccc(cc1)....
132 5C2A Ki = 4.8 nM 4Y2 C14 H17 Cl N4 S Cc1c(nc(nc....
133 4DDL ic50 = 4.9 nM 0JQ C24 H30 N4 O3 Cc1cc(cnc1....
134 4P0N ic50 = 3.4 nM 1IR C18 H17 N5 O S COc1nc2ccc....
135 5EDG - 5MG C20 H12 Cl F3 N4 O2 c1ccc(cc1)....
136 4LLX Ki = 1300 uM 5ZE C6 H9 N3 Cc1cc(nc(n....
137 5C28 Ki = 2.2 uM 4XV C8 H10 Cl N3 Cc1c(nc(nc....
138 2OUU - 35G C10 H12 N5 O7 P c1nc2c(n1[....
139 4MVH ic50 = 4.5 nM 2F5 C22 H19 N5 O3 c1ccc2c(c1....
140 4HEU ic50 = 0.097 nM 15J C24 H25 N5 O2 c1ccc2c(c1....
141 4LLJ Ki = 380 uM 1XN C8 H9 N3 c1ccc2c(c1....
142 3SNI ic50 = 11 nM 546 C18 H17 N5 O Cc1ccncc1c....
143 4HF4 ic50 = 2.4 nM 15H C24 H25 N5 O2 S C[C@@H](C1....
144 3SN7 ic50 = 0.7 nM 540 C19 H17 F N4 O Cc1cnccc1c....
145 4AEL ic50 = 12 nM 4HN C23 H17 N3 O2 CCOc1ccccc....
146 4LLK Ki = 990 uM MEW C9 H8 N2 O CC1=Nc2ccc....
147 4MSA Ki = 500 uM 2ZM C7 H5 N3 O2 c1cc2c(cc1....
148 4MS0 Ki = 410 uM 2ZX C4 H5 Cl N4 c1c(nc(nc1....
149 4LM0 Ki = 560 uM 5NI C7 H5 N3 O2 c1cc2c(cc1....
150 4DFF Ki = 35 nM 0JP C16 H15 N3 O2 S COc1cc2c(c....
151 3WI2 ic50 = 601 nM P98 C26 H23 N3 O CC(C)c1nc2....
152 4MRZ Ki = 300 uM 2ZV C6 H7 N3 O2 Cc1ccnc(c1....
153 4LM1 Ki = 590 uM 7ZE C9 H6 N2 O2 c1cc2c(ccc....
154 5DH4 Ki = 58 nM 5AV C12 H12 Cl N5 S Cc1c(sc(n1....
155 5XUJ - 8G6 C13 H10 Cl N3 Cc1cc2nccc....
156 3UUO Ki = 11 nM 0CV C17 H21 N5 O Cc1cc(cc2c....
157 4MSN Ki = 94 uM 2ZQ C9 H6 N2 O2 c1cc2cccnc....
158 4XY2 ic50 = 8 nM 490 C25 H23 N5 O2 Cn1cc(c(n1....
159 5LAQ Ki = 0.63 nM 6M5 C33 H40 N6 O4 COc1ccc(cc....
160 3SHZ ic50 = 35.9 nM 5CO C20 H27 Cl N4 O4 S CCCOc1ccc(....
161 4G2W ic50 > 1000 nM NI0 C22 H32 N4 O4 S CCCOc1ccc(....
162 3QI4 ic50 = 117.2 uM IBM C10 H14 N4 O2 CC(C)CN1c2....
163 4QGE ic50 = 0.6 nM 35O C20 H24 N6 O3 C[C@H](C(=....
164 3QI3 - PDB C15 H12 Cl F3 N4 O C[C@H](CC1....
165 4Y86 ic50 = 58 nM 49E C18 H20 Cl N5 O CC(c1ccc(c....
166 3ECN ic50 = 700 uM IBM C10 H14 N4 O2 CC(C)CN1c2....
167 3HQW ic50 = 51 nM PF4 C21 H18 N2 O2 S COc1ccc(cc....
168 3QPO ic50 = 247 nM PFR C27 H28 N4 O2 COc1cc2c(c....
169 2OVV Kd = 12 nM PFH C24 H23 N3 O3 COc1cc2c(c....
170 3HR1 ic50 = 0.37 nM PF9 C25 H20 N4 O Cn1cc(c(n1....
171 3QPN ic50 = 17 nM PFK C20 H17 N3 O2 COc1cc2cnc....
172 3HQZ ic50 = 0.42 nM PF8 C24 H18 N4 O c1ccc2c(c1....
173 2O8H Ki = 25 nM 227 C24 H29 N5 O4 S CN1CCN(CC1....
174 3HQY ic50 = 11.5 nM PF6 C25 H20 N4 O c1ccc2c(c1....
175 2OVY Ki = 4 nM PFJ C22 H21 N5 O3 COc1cc2c(c....
176 3QPP ic50 = 12 nM PFW C31 H30 N4 O2 COc1cc2c(c....
177 2QYK ic50 = 3.3 uM NPV C21 H13 N3 O4 c1cc(cc(c1....
178 3GWT ic50 = 7.94 pM 066 C27 H26 N4 O5 S Cc1cc(cc2c....
179 3WD9 ic50 = 8.3 nM QPC C24 H27 N5 O2 CC(C)(C)CN....
180 4KP6 ic50 = 0.87 nM 1S1 C12 H17 N9 CCC(CC)(C#....
181 4NW7 ic50 = 237 nM 2O5 C20 H17 Cl N4 O2 c1cc(cc(c1....
182 3FRG ic50 = 4 nM SK4 C18 H17 N3 O4 S COc1cccc(c....
183 1RO9 - 8BR C10 H13 Br N5 O7 P c1nc(c2c(n....
184 1XOT ic50 = 3.8 uM VDN C23 H32 N6 O4 S CCCc1nc(c2....
185 1XLX ic50 = 0.025 uM CIO C20 H25 N O4 COc1ccc(cc....
186 3O57 ic50 = 79.4 pM ZG2 C29 H34 N6 O3 CCn1c2c(cn....
187 3HMV - HBT C17 H17 N3 O4 S C[C@H]1CCc....
188 3O56 ic50 = 794 pM ZG1 C21 H27 N7 O3 CCn1c2c(cn....
189 1XLZ ic50 = 0.96 uM FIL C15 H20 N2 O4 C/C(=NOC(=....
190 1XN0 ic50 = 0.57 uM ROL C16 H21 N O3 COc1ccc(cc....
191 1TB5 - AMP C10 H14 N5 O7 P c1nc(c2c(n....
192 3D3P ic50 = 3.1 nM 20A C21 H25 N5 O2 CCn1c2c(cn....
193 3W5E ic50 = 11 nM NVW C25 H28 N4 O3 S CC(C)(C)NC....
194 4MYQ ic50 = 32 nM 19T C19 H18 Cl N3 O2 S CCc1c(nc(n....
195 2QYL ic50 = 0.65 uM NPV C21 H13 N3 O4 c1cc(cc(c1....
196 1XOS ic50 = 20 uM VIA C22 H30 N6 O4 S CCCc1c2c(n....
197 1XM6 ic50 = 0.42 uM 5RM C14 H19 N O4 CCCOc1cc(c....
198 1RO6 Ki ~ 375 nM ROL C16 H21 N O3 COc1ccc(cc....
199 1Y2H ic50 = 0.056 uM 6DE C14 H15 Cl N2 O2 CCOC(=O)c1....
200 1ROR - AMP C10 H14 N5 O7 P c1nc(c2c(n....
201 5UOY ic50 = 0.027 uM 8HM C24 H27 N5 O3 S COc1ccc(cc....
202 5W6E ic50 = 21 nM 0NY C17 H21 N5 O2 Cc1cc([nH]....
203 5B25 Kd = 0.058 nM 4QJ C29 H26 F N7 O CN1C(=O)c2....
204 5UP0 ic50 = 0.46 uM 8HP C18 H15 Cl N4 O S c1cc(ccc1C....
205 3G4G ic50 = 19 nM D71 C19 H13 N5 O4 c1cc(cc(c1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: LKF; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 LKF 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5C2H; Ligand: 4PX; Similar sites found with APoc: 178
This union binding pocket(no: 1) in the query (biounit: 5c2h.bio2) has 40 residues
No: Leader PDB Ligand Sequence Similarity
1 4F4S EFO None
2 3KPE TM3 None
3 5NNT DPV None
4 5IUY BOG 1.38122
5 5OPM DTP 1.65746
6 1CM0 COA 1.78571
7 4JZX 476 1.9337
8 6C1R EFD 1.9337
9 4NKW PLO 1.9337
10 3B6C SDN 2.13675
11 2BHW NEX 2.15517
12 5BU2 RIB 2.20994
13 5ZKC 3C0 2.20994
14 1TIQ COA 2.22222
15 4TO8 FLC 2.39726
16 1NF8 BOG 2.41546
17 3HYW DCQ 2.48619
18 2DW7 SRT 2.48619
19 5ICK FEZ 2.62009
20 4TQ3 GPP 2.64026
21 4GN8 ASO 2.67559
22 1I0B PEL 2.71084
23 5JOG 6LT 2.72374
24 6GBX S77 2.73556
25 1J78 VDY 2.76243
26 4AMW 5DI 2.76243
27 1R6N 434 2.8436
28 2WOR 2AN 3
29 5I8F ML1 3.0303
30 6FX0 E9T 3.03867
31 4TV1 36M 3.03867
32 3UUD EST 3.03867
33 4DE3 DN8 3.04183
34 3G2Y GF4 3.04183
35 5WGD EST 3.06513
36 5WGQ EST 3.06513
37 5DXE EST 3.06513
38 1TMX HGX 3.07167
39 1M2Z BOG 3.11284
40 2HJ3 FAD 3.2
41 2UW1 GVM 3.25444
42 5HV7 RBL 3.31492
43 5IKR ID8 3.31492
44 4V1F BQ1 3.48837
45 5V3Y 5V8 3.4965
46 4XCP PLM 3.52941
47 2WPW ACO 3.53982
48 2WPX ACO 3.53982
49 6CGN DA 3.59116
50 5UNJ RJW 3.59116
51 1ZED PNP 3.59116
52 3E70 GDP 3.65854
53 5AZC PGT 3.66667
54 5V4R MGT 3.7037
55 1DTL BEP 3.72671
56 1O4T OXL 3.7594
57 2GN2 C5P 3.80117
58 4RHP PEF 3.82979
59 4G8R 96P 3.8674
60 6BYM HC3 3.94089
61 4N6W FLC 3.94737
62 6HQD SRT 4.14365
63 1YC4 43P 4.16667
64 3QP8 HL0 4.34783
65 5C1M CLR 4.39189
66 5C1M OLC 4.39189
67 5OLK DTP 4.41989
68 3SQP 3J8 4.41989
69 5AHS COA 4.41989
70 3W54 RNB 4.55927
71 4J24 EST 4.58333
72 1ZPD CIT 4.69613
73 3B9Z CO2 4.69613
74 4MGA 27L 4.70588
75 4MG8 27J 4.70588
76 4TUZ 36J 4.70588
77 4MGD 27N 4.70588
78 4DW4 U5P 4.79042
79 5W7B MYR 4.96454
80 2HHP FLC 4.97238
81 5OM2 DXT 5
82 2GBB CIT 5.12821
83 5UGW GSH 5.14286
84 3O01 DXC 5.19481
85 4DR9 BB2 5.20833
86 5LX9 OLB 5.21173
87 5B4B LP5 5.24194
88 4WGF HX2 5.36585
89 2GWH PCI 5.36913
90 1NRL SRL 5.37975
91 1OW4 2AN 5.42636
92 5KAU RHQ 5.45455
93 1GEG GLC 5.46875
94 5XJ7 87O 5.47264
95 5LWY OLB 5.47945
96 5M37 9SZ 5.65217
97 3D04 SAK 5.66038
98 5M36 9SZ 5.67686
99 3B99 U51 5.80111
100 5CHR 4NC 5.83942
101 3RET SAL 5.94059
102 3TDC 0EU 6.07735
103 5IM3 DTP 6.35359
104 4U0S ADP 6.39535
105 2HFN FMN 6.53595
106 2JC9 ADN 6.62983
107 4UMJ BFQ 7.09459
108 3ET3 ET1 7.19178
109 3ET1 ET1 7.2165
110 1NU4 MLA 7.2165
111 3N7S 3N7 7.29167
112 5X3R 7Y3 7.31707
113 6FS0 E4W 7.33945
114 2E3N 6CM 7.45098
115 1TV5 N8E 7.67494
116 5OSW DIU 7.73481
117 4OGQ 7PH 7.80781
118 4OGQ 2WD 7.80781
119 4OGQ 1O2 7.80781
120 3BP1 GUN 7.93103
121 3F8C HT1 7.93651
122 5MTE BB2 8.0292
123 3E3U NVC 8.12183
124 3B1M KRC 8.12721
125 2HFP NSI 8.15603
126 2D5X L35 8.21918
127 3T64 DU3 8.28729
128 1NBU PH2 8.40336
129 2PRG BRL 8.48709
130 2RH1 CLR 8.56354
131 3B96 MYA 8.56354
132 5OCA 9QZ 8.73016
133 1XVB 3BR 8.82353
134 4ZGM 32M 9.01639
135 1YKD CMP 9.11602
136 5TDC NMM ILE PHE SER 9.21053
137 5Y02 HBX 9.34579
138 1Q1Y BB2 9.42408
139 4BTB PRO PRO PRO PRO PRO PRO PRO PRO PRO 9.62343
140 3NJQ NJQ 9.84456
141 4UCC ZKW 9.87124
142 5MWE TCE 9.87654
143 1MID LAP 9.89011
144 1BWO LPC 10
145 5C9J DAO 10.101
146 4DK7 0KS 10.1215
147 5N8V KZZ 10.1449
148 1N8V BDD 10.7143
149 6EVN PRO PRO GLY PRO ALA GLY PRO PRO GLY 10.7843
150 2ALG DAO 10.8696
151 2OZ5 7XY 11.1486
152 1HBK MYR 11.236
153 5UC4 83S 11.3636
154 6BR9 PGV 12.5348
155 6BR9 6OU 12.5348
156 3KO0 TFP 12.8713
157 5H9O GLC 13.6364
158 4ETZ C2E 14.4781
159 4RW3 TDA 14.9007
160 6BVM EBV 14.9701
161 6BVK EAV 14.9701
162 1XW6 GSH 15.1376
163 6BR8 PGV 16.6667
164 6BR8 6OU 16.6667
165 2CB8 MYA 17.2414
166 2BCG GER 18.932
167 2VWA PTY 20.7921
168 3KP6 SAL 23.8411
169 2Y69 CHD 25.3968
170 5Z84 CHD 30.5085
171 5ZCO CHD 30.5085
172 5W97 CHD 30.5085
173 5ZCO PEK 30.5085
174 1UO4 PIH 35.2941
175 5OHJ 9VE 38.3978
176 5G57 6M5 39.4444
177 4OAR 2S0 41.1765
178 3BJC WAN 47.5138
Pocket No.: 2; Query (leader) PDB : 5C2H; Ligand: 4XU; Similar sites found with APoc: 160
This union binding pocket(no: 2) in the query (biounit: 5c2h.bio1) has 33 residues
No: Leader PDB Ligand Sequence Similarity
1 3KPE TM3 None
2 4F4S EFO None
3 6CS9 PIO None
4 4WG0 CHD None
5 5IUY BOG 1.38122
6 6BMS POV 1.46628
7 5OPM DTP 1.65746
8 5OKL PAM 1.65746
9 3AJM 4IP 1.87793
10 4NKW PLO 1.9337
11 4JZX 476 1.9337
12 3B6C SDN 2.13675
13 2BHW XAT 2.15517
14 5VRH OLB 2.20994
15 1TIQ COA 2.22222
16 1NF8 BOG 2.41546
17 5ICK FEZ 2.62009
18 1I0B PEL 2.71084
19 1R6N 434 2.8436
20 2WOR 2AN 3
21 5I8F ML1 3.0303
22 4TV1 36M 3.03867
23 2HZL PYR 3.03867
24 4DE3 DN8 3.04183
25 3G2Y GF4 3.04183
26 1TMX HGX 3.07167
27 1M2Z BOG 3.11284
28 3P9T TCL 3.19635
29 2HJ3 FAD 3.2
30 2WQ4 SFU 3.20513
31 2UW1 GVM 3.25444
32 4M52 M52 3.31492
33 5V3Y 5V8 3.4965
34 4XCP PLM 3.52941
35 5UNJ RJW 3.59116
36 2W92 NGT 3.59116
37 3E70 GDP 3.65854
38 5AZC PGT 3.66667
39 5V4R MGT 3.7037
40 1DTL BEP 3.72671
41 2GN2 C5P 3.80117
42 4DOO DAO 3.90244
43 3L9R L9R 4.08163
44 6AP8 BNY 4.08922
45 6HQD SRT 4.14365
46 5DCH 1YO 4.16667
47 3QP8 HL0 4.34783
48 5C1M CLR 4.39189
49 5OLK DTP 4.41989
50 5AHS COA 4.41989
51 1QPR PHT 4.57746
52 2YJD YJD 4.58333
53 3B9Z CO2 4.69613
54 1ZPD CIT 4.69613
55 6B21 C9V 4.69613
56 4MGA 27L 4.70588
57 4MG9 27K 4.70588
58 4TUZ 36J 4.70588
59 4MG8 27J 4.70588
60 4DW4 U5P 4.79042
61 3GL0 HXX 4.87106
62 4XPL ACO 4.90798
63 5W7B MYR 4.96454
64 2HHP FLC 4.97238
65 2GBB CIT 5.12821
66 5UGW GSH 5.14286
67 3O01 DXC 5.19481
68 4DR9 BB2 5.20833
69 5LX9 OLB 5.21173
70 4WGF HX2 5.36585
71 2GWH PCI 5.36913
72 1NRL SRL 5.37975
73 1OW4 2AN 5.42636
74 5KAU RHQ 5.45455
75 5XJ7 87O 5.47264
76 5LWY OLB 5.47945
77 1X0P FAD 5.59441
78 5M36 9SZ 5.67686
79 3AI3 SOE 5.70342
80 3B99 U51 5.80111
81 5CHR 4NC 5.83942
82 5NM7 GLY 6.01504
83 3NB0 G6P 6.07735
84 2O1V ADP 6.07735
85 4D52 GIV 6.34921
86 4D52 GXL 6.34921
87 5IM3 DTP 6.35359
88 4DXJ 0M9 6.35359
89 6BT4 KPM 6.35359
90 4RYV ZEA 6.45161
91 1VJ7 GPX 6.62983
92 2JC9 ADN 6.62983
93 4UMJ BFQ 7.09459
94 3ET3 ET1 7.19178
95 1NU4 MLA 7.2165
96 3ET1 ET1 7.2165
97 5XQL C2E 7.2165
98 3N7S 3N7 7.29167
99 6FS0 E4W 7.33945
100 6CB2 OLC 7.50853
101 2ZFZ ARG 7.59494
102 1TV5 N8E 7.67494
103 1G27 BB1 7.7381
104 4OGQ 2WD 7.80781
105 4OGQ UMQ 7.80781
106 4OGQ 7PH 7.80781
107 4OGQ 1O2 7.80781
108 3F8C HT1 7.93651
109 5MTE BB2 8.0292
110 4G86 BNT 8.09859
111 3E3U NVC 8.12183
112 2HFK E4H 8.15047
113 4Q0A GLY HIS LYS ILE LEU HIS ARG LEU LEU GLN 8.27815
114 3T64 DU3 8.28729
115 1WS1 BB2 8.33333
116 2RH1 CLR 8.56354
117 3B96 MYA 8.56354
118 2RH1 CAU 8.56354
119 5TVI MYR 8.69565
120 5OCA 9QZ 8.73016
121 1XVB 3BR 8.82353
122 4ZGM 32M 9.01639
123 2IDO TMP 9.13978
124 5Y02 HBX 9.34579
125 1Q1Y BB2 9.42408
126 4BTB PRO PRO PRO PRO PRO PRO PRO PRO PRO 9.62343
127 3NJQ NJQ 9.84456
128 4UCC ZKW 9.87124
129 5MWE TCE 9.87654
130 5WL1 D3D 10.101
131 5WL1 CUY 10.101
132 5N8V KZZ 10.1449
133 1N8V BDD 10.7143
134 6EVN PRO PRO GLY PRO ALA GLY PRO PRO GLY 10.7843
135 1HBK MYR 11.236
136 5UC4 83S 11.3636
137 1T0S BML 11.6279
138 6BR9 PGV 12.5348
139 6BR9 6OU 12.5348
140 3KO0 TFP 12.8713
141 3RV5 DXC 14.6067
142 6BVK EAV 14.9701
143 6BVM EBV 14.9701
144 6BR8 PGV 16.6667
145 6BR8 6OU 16.6667
146 3L1N PLM 17.0103
147 2CB8 MYA 17.2414
148 2BCG GER 18.932
149 2VWA PTY 20.7921
150 5EY0 GTP 21.1679
151 1ZEI CRS 22.6415
152 3KP6 SAL 23.8411
153 2Y69 CHD 25.3968
154 5Z84 CHD 30.5085
155 5ZCO CHD 30.5085
156 5W97 CHD 30.5085
157 1UO4 PIH 35.2941
158 5OHJ 9VE 38.3978
159 5G57 6M5 39.4444
160 3BJC WAN 47.5138
APoc FAQ
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