Receptor
PDB id Resolution Class Description Source Keywords
3zrl 2.48 Å EC: 2.7.11.26 IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK-3BET INHIBITORS HOMO SAPIENS TRANSFERASE-PEPTIDE COMPLEX KINASE
Ref.: IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK-3BETA INHIBITORS. BIOORG.MED.CHEM.LETT. V. 21 4823 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GOL A:1389;
B:1388;
B:1389;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
SO4 A:1386;
A:1387;
A:1388;
B:1385;
B:1386;
B:1387;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
ZRL A:1390;
B:1390;
Valid;
Valid;
none;
none;
ic50 = 0.16 uM
307.166 C12 H7 Br N2 O S c1cnc...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3ZRM 2.49 Å EC: 2.7.11.26 IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK- 3BETA INHIBITORS HOMO SAPIENS TRANSFERASE-PEPTIDE COMPLEX KINASE
Ref.: IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK-3BETA INHIBITORS. BIOORG.MED.CHEM.LETT. V. 21 4823 2011
Members (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 3ZRL ic50 = 0.16 uM ZRL C12 H7 Br N2 O S c1cnccc1c2....
2 3ZRM ic50 = 0.13 uM ZRM C18 H12 N2 O2 S c1cc(ccc1C....
3 4AFJ ic50 = 0.4 uM SJJ C17 H15 N3 O3 COc1ccc(cc....
4 3ZRK ic50 = 0.13 uM ZRK C12 H8 N2 O2 c1cnccc1c2....
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 3ZRL ic50 = 0.16 uM ZRL C12 H7 Br N2 O S c1cnccc1c2....
2 3ZRM ic50 = 0.13 uM ZRM C18 H12 N2 O2 S c1cc(ccc1C....
3 4AFJ ic50 = 0.4 uM SJJ C17 H15 N3 O3 COc1ccc(cc....
4 3ZRK ic50 = 0.13 uM ZRK C12 H8 N2 O2 c1cnccc1c2....
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 3ZRL ic50 = 0.16 uM ZRL C12 H7 Br N2 O S c1cnccc1c2....
2 3ZRM ic50 = 0.13 uM ZRM C18 H12 N2 O2 S c1cc(ccc1C....
3 4AFJ ic50 = 0.4 uM SJJ C17 H15 N3 O3 COc1ccc(cc....
4 3ZRK ic50 = 0.13 uM ZRK C12 H8 N2 O2 c1cnccc1c2....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ZRL; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 ZRL 1 1
2 ZRM 0.530303 0.76087
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3ZRM; Ligand: ZRM; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 3zrm.bio1) has 19 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc)
Pocket No.: 2; Query (leader) PDB : 3ZRM; Ligand: ZRM; Similar sites found: 620
This union binding pocket(no: 2) in the query (biounit: 3zrm.bio1) has 20 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc)
1 1O9U ADZ 0.0000000000278 0.92876
2 3OWL 19E 0.000000004965 0.75117
3 3OWK 18E 0.00000001336 0.72342
4 4KWP EXX 0.0000000143 0.72235
5 4F1T H52 0.00000005616 0.71303
6 3BRB ADP 0.00000001346 0.70293
7 4GRB 0XG 0.000000009296 0.69894
8 4X0M 3WA 0.00000005422 0.69739
9 4BCQ TJF 0.00000001878 0.69582
10 3BRB ADP 0.00000002263 0.69185
11 4CFU 2WC 0.000000011 0.68435
12 4BCN T9N 0.00000001103 0.68428
13 4BCN T9N 0.000000006767 0.68351
14 4GW8 3RA 0.00000001966 0.68336
15 3TKI S25 0.000000006194 0.68221
16 4MQ1 2C3 0.000000005436 0.67513
17 4CFU 2WC 0.00000001107 0.67377
18 4AU8 Z3R 0.00000003453 0.67164
19 4MXO DB8 0.0000001698 0.67027
20 4RLL E91 0.0000001483 0.66993
21 4AU8 Z3R 0.0000000381 0.6696
22 4AU8 Z3R 0.0000000381 0.6696
23 3LQ8 88Z 0.00000009962 0.66956
24 4AUA 4AU 0.0000001139 0.66862
25 4MXO DB8 0.0000001585 0.66538
26 4BCM T7Z 0.000000003818 0.66289
27 3RWP ABQ 0.0000006777 0.66184
28 3RWP ABQ 0.0000006777 0.66184
29 3O0G 3O0 0.00000000426 0.66089
30 4BCQ TJF 0.00000006157 0.65961
31 4MQ1 2C3 0.00000001564 0.65811
32 4MQ1 2C3 0.00000001432 0.65656
33 2XNM WGZ 0.00000004866 0.65477
34 3JPV 1DR 0.0000002285 0.65336
35 4N70 2HX 0.0000000522 0.65275
36 4MQ1 2C3 0.00000001507 0.65221
37 4F4P 0SB 0.0000001996 0.64893
38 4F1O ACP 0.00000006347 0.64879
39 3HMO STU 0.00000002525 0.64792
40 3HZT J60 0.0000001083 0.64787
41 2YEX YEX 0.0000001807 0.64775
42 3BI6 396 0.00000002844 0.64658
43 2XB7 GUI 0.0000001937 0.64631
44 2XMY CDK 0.0000004399 0.64499
45 2A19 ANP 0.0000001272 0.64452
46 4K1B 1OC 0.0000000107 0.64434
47 4OAC ADP 0.00000002052 0.64282
48 4L3L 5FI 0.00000009125 0.64224
49 3VBQ 0F5 0.0000003253 0.64181
50 3E7O 35F 0.0000001215 0.64089
51 2F2U M77 0.0000001561 0.64027
52 4F1M ACP 0.00000006278 0.63939
53 1V0O INR 0.00000002711 0.63755
54 3E7O 35F 0.0000001436 0.6354
55 4EUU BX7 0.00000009916 0.63342
56 4IZY 1J2 0.000000006497 0.63314
57 4ASE AV9 0.0000001275 0.63092
58 2ZV2 609 0.0000002609 0.62958
59 3THB 3TA 0.0000002965 0.62881
60 3THB 3TA 0.0000002965 0.62881
61 3SRV S19 0.00000002488 0.62776
62 3SRV S19 0.00000001222 0.62767
63 1UNH IXM 0.00000001533 0.62537
64 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.000001338 0.62485
65 2JDR L20 0.000001338 0.62485
66 4X2J 3WN 0.0000001343 0.62432
67 4X2K 3WO 0.0000001343 0.62432
68 3R0T FU9 0.00000003111 0.62371
69 1MQB ANP 0.00000006826 0.62343
70 1UNH IXM 0.000000009311 0.62219
71 4N6Z 2HW 0.0000002419 0.62163
72 2J7T 274 0.0000002617 0.62123
73 2X4Z X4Z 0.000000402 0.62075
74 4CCU AWF 0.0000001029 0.62072
75 4BKY 82B 0.0000001155 0.61956
76 2J51 DKI 0.0000001124 0.61901
77 1U59 STU 0.00000007333 0.61871
78 4NWM 2P5 0.000001069 0.61835
79 3V8T 477 0.0000001926 0.61784
80 4OH4 ANP 0.00000007954 0.61718
81 4GJ3 0XP 0.0000003728 0.6163
82 2P2H 994 0.0000002073 0.61572
83 3V8T 477 0.0000009943 0.61556
84 3V8T 477 0.0000009943 0.61556
85 3CY2 MB9 0.000000005963 0.61487
86 2XVD AS6 0.0000003232 0.61482
87 2OIC STU 0.0000002201 0.61454
88 3V8S 0HD 0.00000005125 0.61447
89 4F9A ADP 0.0000001433 0.61431
90 3KF4 B90 0.0000008569 0.61401
91 4F9A ADP 0.0000001462 0.61393
92 1RE8 BD2 0.000001165 0.61373
93 3V8S 0HD 0.00000005389 0.61334
94 4C58 824 0.0000001513 0.61326
95 4CTC J99 0.00000005594 0.61292
96 3A7H ATP 0.000001819 0.61252
97 4QTC 38Z 0.0000002539 0.61244
98 2CSN CKI 0.0000002919 0.61217
99 2OFV 242 0.000000675 0.61208
100 3KF4 B90 0.000001268 0.61196
101 3GC0 AMP 0.00000001492 0.61114
102 4F99 ADP 0.0000001752 0.61042
103 4CMO YPW 0.00000006744 0.60979
104 4OA2 ADP 0.00000005386 0.60976
105 4CCB OFG 0.0000001268 0.60835
106 2WTV ZZL 0.00001018 0.60768
107 4MBI 26K 0.0000007778 0.60686
108 2WQN ADP 0.000000503 0.60678
109 4CMT GWH 0.0000001944 0.60659
110 4CTB KVC 0.0000001707 0.60597
111 2F57 23D 0.00000005148 0.60566
112 2F2U M77 0.000000845 0.60514
113 2YAK OSV 0.0000006042 0.60455
114 2QCS ANP 0.0000004313 0.60449
115 4K77 1Q4 0.000001362 0.60441
116 4JQE ANP 0.0000001564 0.60438
117 3CXW 7CP 0.00000009065 0.60417
118 1ZY5 ANP 0.00000009749 0.60253
119 3GGF GVD 0.0000006285 0.60226
120 2OIC STU 0.0000006308 0.60219
121 1V0O INR 0.00000008645 0.60162
122 1U5R ATP 0.0000002767 0.60157
123 1U5R ATP 0.0000002767 0.60157
124 3PE2 E1B 0.00000001601 0.60092
125 2WU6 DKI 0.00000001088 0.60058
126 3FHI ANP 0.0000005389 0.60011
127 3EYH IZA 0.0000001999 0.59973
128 4UAL 3FV 0.0000002002 0.59971
129 3PE1 3NG 0.00000003425 0.59963
130 4F65 0S9 0.000001726 0.59959
131 2X2M X2M 0.000000326 0.59957
132 3BU5 ATP 0.0000002037 0.59938
133 3A8W ATP 0.0000002059 0.59918
134 3BQC EMO 0.00000002414 0.5991
135 2VN9 GVD 0.000000009398 0.59811
136 4CLI 5P8 0.0000001292 0.59792
137 4CNH 3U9 0.0000002266 0.59737
138 2VAG V25 0.0000002415 0.59616
139 3RE4 TO1 0.000001303 0.59612
140 2QLU ADE 0.000005532 0.59609
141 4U44 3D9 0.0000002435 0.596
142 4U44 3D9 0.0000002435 0.596
143 2OIC STU 0.0000008769 0.59551
144 1XJD STU 0.0000002637 0.59449
145 3MB6 01I 0.000000001206 0.59389
146 3TXO 07U 0.00000009768 0.59359
147 3TXO 07U 0.00000009768 0.59359
148 3A8W ATP 0.00000034 0.58969
149 3A8W ATP 0.00000034 0.58969
150 4CNH 3U9 0.000001827 0.5891
151 4CLJ 5P8 0.0000005499 0.58828
152 2WTV ZZL 0.000000595 0.58797
153 2Y6O 1N1 0.00000004298 0.58754
154 2NRY STU 0.000000586 0.58705
155 2PZI AXX 0.000001334 0.58699
156 4BFM ANP 0.0000001042 0.5854
157 3RE4 TO1 0.0000006456 0.58518
158 2OIC STU 0.000001463 0.58512
159 2V7O DRN 0.00000001685 0.5851
160 2NRY STU 0.0000006501 0.58504
161 4EHZ JAK 0.000001473 0.58498
162 4NST ADP 0.0000004373 0.58492
163 4BBF O19 0.0000002759 0.58411
164 4BCM T7Z 0.000000007382 0.58348
165 4O1P ANP 0.0000004724 0.58346
166 2PUL ACP 0.0000007095 0.58335
167 2PUL ACP 0.0000007095 0.58335
168 4BBF O19 0.0000005685 0.58306
169 3GGF GVD 0.000001087 0.58289
170 3GGF GVD 0.000001087 0.58289
171 4O1P ANP 0.0000003008 0.58282
172 4K77 1Q4 0.000002481 0.58274
173 3DAK ANP 0.000001122 0.58226
174 4E4N 0NL 0.0000005066 0.58214
175 4KS7 X4Z 0.00000003314 0.58188
176 4BBE 3O4 0.00000002643 0.5818
177 4AT3 LTI 0.0000007772 0.58158
178 1Q8Y ADE 0.00000002509 0.58131
179 2B9H ADP 0.0000006308 0.58108
180 4BHN BH9 0.000001127 0.58083
181 4BHN BH9 0.0000008705 0.58064
182 4NST ADP 0.0000005522 0.58051
183 4IJP 1EH 0.0000007652 0.58033
184 4BBE 3O4 0.00000003093 0.58027
185 4OTH DRN 0.0000003431 0.58016
186 2Z7R STU 0.00000006735 0.57989
187 4EHZ JAK 0.000001986 0.57892
188 1ZP9 ATP 0.000001341 0.57873
189 4BBF O19 0.00000037 0.57866
190 1K3A ACP 0.0000001167 0.5784
191 1ZP9 ATP 0.000001367 0.57835
192 4NFN 2KC 0.0000009238 0.57824
193 2NRY STU 0.000001388 0.57806
194 4F0F ACP 0.0000002036 0.57749
195 2WTV ZZL 0.000001201 0.57706
196 1U5R ATP 0.0000006653 0.57698
197 4BBF O19 0.0000006695 0.57686
198 4H3Q ANP 0.000001214 0.57686
199 4G16 0VM 0.0000002272 0.57686
200 2NRU T12 0.0000007955 0.57666
201 2WTV ZZL 0.000001087 0.57635
202 2NRU T12 0.0000004494 0.5759
203 4EHZ JAK 0.000002314 0.57582
204 3EQR T74 0.000001861 0.57572
205 3EQR T74 0.000001861 0.57572
206 3PTG 932 0.00000003685 0.57561
207 4IVB 1J5 0.00000163 0.57487
208 4C2V YJA 0.000002679 0.57486
209 3ALN ANP 0.000003673 0.57457
210 3AT4 CCK 0.00000005916 0.57379
211 2PZI AXX 0.000002575 0.57365
212 4I5C C5I 0.0000009487 0.57331
213 3UIM ANP 0.0000008105 0.57324
214 3ZOS 0LI 0.000002411 0.57282
215 4I5C C5I 0.000001019 0.57194
216 4EHZ JAK 0.000002812 0.57186
217 3M2W L8I 0.0000001803 0.57184
218 3SXF BK5 0.00000452 0.57174
219 2HK5 1BM 0.000001248 0.57096
220 3QUP LUN 0.0000005483 0.57093
221 2O2U 738 0.000001992 0.5709
222 1ZP9 ATP 0.000001353 0.57085
223 4I6H 1C8 0.0000009235 0.57077
224 4BBE 3O4 0.0000001637 0.57068
225 4G17 0VN 0.0000003385 0.57017
226 4CMU IV7 0.000000344 0.5698
227 3KN5 ANP 0.0000005981 0.5696
228 4KNB 1RU 0.0000003822 0.56949
229 4MKC 4MK 0.000001409 0.56862
230 3EQR T74 0.000002384 0.56858
231 3TZM 085 0.000001637 0.56846
232 2B9J ADP 0.000001536 0.5684
233 2VN9 GVD 0.00000003086 0.56823
234 4E6Q 0NV 0.0000005436 0.56821
235 3A7H ATP 0.000001605 0.56755
236 3A7H ATP 0.000001605 0.56755
237 3PLS ANP 0.0000006986 0.56746
238 4IDT T28 0.000001682 0.56664
239 4E4N 0NL 0.0000006134 0.56612
240 4JX7 1N6 0.000003775 0.56589
241 2H8H H8H 0.000001213 0.56561
242 4KNB 1RU 0.0000004761 0.56507
243 2B9F ADP 0.000001263 0.56485
244 4FOC 0UU 0.000001878 0.5645
245 1XR1 ANP 0.0000006508 0.56436
246 4JDI ANP 0.0000003686 0.56401
247 3ZBF VGH 0.0000004808 0.56358
248 2ZM3 575 0.0000003256 0.56323
249 4IVC 1J6 0.000000722 0.56301
250 1ZP9 ATP 0.00000203 0.563
251 2B9I ADP 0.000001395 0.56297
252 2XK9 XK9 0.000007651 0.56274
253 4OAV ACP 0.0000009098 0.56241
254 4IVC 1J6 0.0000007507 0.56225
255 4IVB 1J5 0.000002153 0.56187
256 4NWM 2P5 0.000002769 0.56088
257 4CD0 AWJ 0.0000002213 0.5608
258 3ALN ANP 0.000002324 0.56038
259 4MWH ATP 0.0000004252 0.56011
260 4MWH ATP 0.0000004252 0.56011
261 2NRY STU 0.000002383 0.5599
262 4C4F 7CE 0.0000004663 0.55901
263 4F9C 0SX 0.000002503 0.55895
264 4PMP 31W 0.000002031 0.55881
265 2PVF ACP 0.000002557 0.55853
266 4U0I 0LI 0.000006714 0.55842
267 3BE2 RAJ 0.000003674 0.5578
268 2NRU T12 0.000002537 0.55736
269 1CM8 ANP 0.000002752 0.55711
270 1CM8 ANP 0.000002835 0.55654
271 4E6Q 0NV 0.000000531 0.55649
272 4IVD 15T 0.0000005434 0.55635
273 3TTI KBI 0.00000115 0.55523
274 4JR7 GNP 0.000004419 0.55511
275 4IVD 15T 0.0000005938 0.55492
276 3DAK ANP 0.000002244 0.55397
277 3DAK ANP 0.000002244 0.55397
278 1BYG STU 0.0000008719 0.55388
279 2VZ6 FEF 0.000006955 0.55349
280 4KNB 1RU 0.0000006134 0.55329
281 3LXN MI1 0.0000006567 0.55262
282 3SXS PP2 0.0000007336 0.5518
283 3EYG MI1 0.000001309 0.55178
284 1Q8Y ADP 0.000003407 0.55171
285 4IJP 1EH 0.000003472 0.55134
286 2ZM3 575 0.0000003016 0.5511
287 4IX4 ADP 0.000003569 0.55082
288 2OID ANP 0.000003869 0.55052
289 4E6D 0NU 0.000001415 0.55037
290 3NW7 LGV 0.00002307 0.55022
291 4DEH 0JK 0.000008438 0.54957
292 2J90 IZA 0.000002837 0.54953
293 2NRU T12 0.000002845 0.54948
294 4OTI MI1 0.000002916 0.54901
295 4KNB 1RU 0.000001196 0.54852
296 4WHZ 3NL 0.00002084 0.54829
297 4PMT 31Y 0.000001656 0.54795
298 4FOB 0US 0.0000002901 0.54775
299 4C2V YJA 0.00001166 0.54737
300 4TWC 37J 0.000004581 0.54725
301 4DCE 0JF 0.0000005197 0.5468
302 4PNI KQQ 0.0000000115 0.5466
303 1ZTH ADP 0.0000006951 0.54646
304 3DLS ADP 0.000001269 0.54644
305 4BBE 3O4 0.0000001255 0.54644
306 4DCE 0JF 0.000001006 0.54638
307 4OH4 ANP 0.000001764 0.54632
308 4H3P ANP 0.000003421 0.54599
309 3UDZ ADP 0.00000407 0.54557
310 3EKK GS2 0.0000003031 0.5451
311 3DLS ADP 0.00000145 0.5441
312 3DLS ADP 0.00000145 0.5441
313 2WEL K88 0.00000004612 0.54409
314 3DLS ADP 0.000001465 0.54388
315 4H3P ANP 0.000003834 0.54383
316 4H1M 0YJ 0.00002103 0.54373
317 4OUC 5ID 0.000001591 0.54354
318 4G31 0WH 0.000003998 0.54304
319 4EQC XR1 0.000000001262 0.54287
320 2YAB AMP 0.000004701 0.54282
321 2ZM3 575 0.000001022 0.54233
322 2OO8 RAJ 0.000006363 0.5423
323 3DLS ADP 0.0000008815 0.54228
324 3DLS ADP 0.0000009699 0.54188
325 1Y57 MPZ 0.0000003288 0.5418
326 3C0I 3AM 0.0000006559 0.54158
327 3UDZ ADP 0.000005098 0.54128
328 3UDZ ADP 0.000005098 0.54128
329 4E4L 0NH 0.000002926 0.54087
330 4E5W 0NT 0.000004499 0.5408
331 4FVQ ATP 0.000006049 0.54071
332 2ZM3 575 0.0000006933 0.54058
333 3C0H AMP 0.0000001781 0.53942
334 3KMW ATP 0.000006992 0.53906
335 4M69 ANP 0.000006646 0.5389
336 2VZ6 FEF 0.00002067 0.53864
337 4EI4 0Q2 0.000001247 0.53825
338 4FK6 0UJ 0.000003352 0.53824
339 1MQB ANP 0.0000003332 0.53797
340 3AQV TAK 0.000005282 0.53777
341 4FK6 0UJ 0.000003552 0.53718
342 2IF8 ADP 0.00004587 0.53713
343 2OID ANP 0.000005634 0.53655
344 3FC2 IBI 0.0000007067 0.5364
345 4C2W ANP 0.00000102 0.53638
346 4LFI GNP 0.000006642 0.53624
347 4UXQ 0LI 0.0000189 0.5359
348 4EI4 0Q2 0.000001474 0.53579
349 1ZTH ADP 0.0000007509 0.5339
350 3C0G 3AM 0.0000008501 0.53372
351 4AZT LY2 0.00002673 0.53329
352 4Q5H ANP 0.000006853 0.53284
353 4QPM ADP 0.000008578 0.53137
354 1ZTH ADP 0.000000891 0.53109
355 3KRL KRL 0.000001236 0.53106
356 1OPK P16 0.000001232 0.53062
357 4E4L 0NH 0.000003226 0.53043
358 2PYW ADP 0.000002522 0.53031
359 3DLS ADP 0.000002043 0.53028
360 1ZTH ADP 0.0000009806 0.53021
361 4DC2 ADE 0.00000002366 0.52922
362 4E4L 0NH 0.000003501 0.52891
363 3KN5 ANP 0.000002128 0.52882
364 4FL3 ANP 0.000001527 0.52875
365 3RI1 3RH 0.0000001637 0.52787
366 3FI3 JK2 0.000005472 0.52691
367 1PHK ATP 0.00001098 0.52667
368 3IGO ANP 0.000001837 0.52658
369 2RFN AM7 0.00001632 0.5265
370 4TWC 37J 0.000005412 0.52639
371 2RIO ADP 0.00001357 0.52623
372 4AT5 MUJ 0.00001563 0.52497
373 3OFM 4B0 0.00000003615 0.52489
374 2PVN P63 0.00000006844 0.5243
375 4AOI 4K0 0.000021 0.52423
376 2RFN AM7 0.00001697 0.52339
377 4K33 ACP 0.00001352 0.52271
378 3IDB ANP 0.000001035 0.52267
379 4CQE CQE 0.000001938 0.52244
380 2WEI VGG 0.000005036 0.52243
381 3EFK MT4 0.00002259 0.52242
382 3EFK MT4 0.00002259 0.52242
383 3GC8 B45 0.000001098 0.52187
384 4LRJ ANP 0.00001735 0.52148
385 2CFM AMP 0.00004754 0.52131
386 3UZP 0CK 0.000007226 0.52065
387 3UZP 0CK 0.000007226 0.52065
388 4E1Z 0MX 0.000001404 0.52016
389 4QTB 38Z 0.000000132 0.51981
390 4CQE CQE 0.000001289 0.51973
391 3UZP 0CK 0.00001393 0.51942
392 3GC8 B45 0.000002547 0.51823
393 3GQI ACP 0.00001492 0.51811
394 3EFK MT4 0.00002548 0.51786
395 3C0G 3AM 0.000000516 0.51749
396 3C0H AMP 0.0000002889 0.51747
397 4QPM ADP 0.00001567 0.51718
398 4GYI ADP 0.00004386 0.51612
399 4TW9 386 0.00002308 0.51595
400 3ZOS 0LI 0.000003821 0.51539
401 4CYI ATP 0.00002017 0.51509
402 4CYI ATP 0.00002712 0.51435
403 4CYI ATP 0.00002431 0.51405
404 1AUX AGS 0.00001856 0.51399
405 4QTB 38Z 0.0000002197 0.51376
406 4LH7 1X8 0.000161 0.51312
407 4CYI ATP 0.00002364 0.51205
408 3FHR P4O 0.00001219 0.51137
409 2QU6 857 0.000001996 0.51061
410 1GSA ADP 0.00003846 0.50988
411 1GSA ADP 0.00003846 0.50988
412 3UYT 0CK 0.00001369 0.50985
413 3UYT 0CK 0.00001401 0.50981
414 2OID ANP 0.00004375 0.5097
415 3UYT 0CK 0.00001369 0.50926
416 3C1X CKK 0.000004631 0.50871
417 4I94 ANP 0.00001202 0.50766
418 3RI1 3RH 0.0000006594 0.5075
419 2VPQ ANP 0.00004752 0.50578
420 1W2D ADP 0.0001012 0.50559
421 2R5T ANP 0.000005785 0.50515
422 2R5T ANP 0.000005785 0.50515
423 1W2D ADP 0.0001151 0.50293
424 1VJY 460 0.0000009182 0.50291
425 4I94 ANP 0.00002289 0.50289
426 2QU6 857 0.000001087 0.50245
427 3E5A VX6 0.000001805 0.50233
428 4OCJ NDG 0.0001737 0.50202
429 4DFU QUE 0.0001657 0.50193
430 3SLS ANP 0.000007312 0.5019
431 3RGF BAX 0.00000221 0.50178
432 2P2I 608 0.000001977 0.49985
433 4PMM 31V 0.000007734 0.49964
434 3PP0 03Q 0.000004954 0.49896
435 2P2I 608 0.00000221 0.49883
436 3ALN ANP 0.00001506 0.49828
437 3SLS ANP 0.000009065 0.49718
438 4DFU QUE 0.000292 0.49656
439 4F9B 0SY 0.000001085 0.49642
440 4LRJ ANP 0.00006339 0.49639
441 2EVA ADN 0.000000251 0.49601
442 3VRY B43 0.000001591 0.49556
443 4MK0 29X 0.00009042 0.49539
444 2R5T ANP 0.000006217 0.49508
445 3H9R TAK 0.000005642 0.49491
446 1IA9 ANP 0.00003069 0.49472
447 2OID ANP 0.00003274 0.49409
448 3UYT 0CK 0.00003517 0.49322
449 3LXK MI1 0.000000934 0.49303
450 4ORK GDP 0.0000603 0.49168
451 3I0O ADP 0.0001989 0.49155
452 3I0O ADP 0.0001989 0.49155
453 3LKM AMP 0.00003971 0.49084
454 4AT4 T6E 0.00002182 0.4907
455 1TQP ATP 0.000004608 0.49035
456 4OCV ANP 0.00004121 0.49017
457 4BKJ STI 0.00001559 0.48893
458 4F9B 0SY 0.000002079 0.48812
459 4FG8 ATP 0.00003328 0.48521
460 4P5Z Q7M 0.00000002598 0.48425
461 3VHE 42Q 0.0000007853 0.4836
462 4ANW O92 0.0003064 0.48345
463 4ORK GDP 0.0000461 0.48259
464 3AKK ADP 0.0001173 0.48154
465 1WBP ADP 0.00001534 0.48062
466 3T7A ADP 0.0006445 0.47991
467 4BKJ STI 0.00001061 0.47924
468 4AG8 AXI 0.0000003331 0.4792
469 3VRY B43 0.000002443 0.47821
470 4CKR DI1 0.000003489 0.4767
471 4E93 GUI 0.0000003835 0.47639
472 3PVW QRX 0.0000056 0.47628
473 4FG8 ATP 0.00003393 0.47569
474 4EYM 0RX 0.0001802 0.47566
475 4ORK GDP 0.0001134 0.47363
476 3PDT ADP 0.0002931 0.47201
477 3ORK AGS 0.00001286 0.47072
478 3VPB ADP 0.00001091 0.47068
479 3WVR AMP 0.00008016 0.47045
480 3WVR AMP 0.00008016 0.47045
481 3HAV ATP 0.0004003 0.47004
482 3VPC ADP 0.00004863 0.46932
483 1IOW ADP 0.0007117 0.46928
484 1IOW PHY 0.0007117 0.46928
485 3WVR AMP 0.0001078 0.46888
486 2BKK ADP 0.000145 0.46885
487 3Q60 ATP 0.0001483 0.46871
488 3GNI ATP 0.00008127 0.4687
489 3ETH ATP 0.000326 0.46642
490 3WVR AMP 0.0001254 0.46583
491 3WVR AMP 0.0001254 0.46583
492 3AKK ADP 0.0001872 0.46496
493 4ME6 ADP 0.001382 0.46434
494 2VQD AP2 0.0001164 0.46398
495 4NW6 2NS 0.000001095 0.46309
496 1PK8 ATP 0.00002336 0.4624
497 4O4F ATP 0.0005057 0.46185
498 3VPD ANP 0.0004136 0.46183
499 3TY5 ATP 0.0008622 0.46103
500 4LOO SB4 0.0003206 0.46006
501 1PK8 ATP 0.00002624 0.45925
502 2BKK ADP 0.0001308 0.45868
503 4O4F IHP 0.0006556 0.45859
504 3PP0 03Q 0.00001626 0.45851
505 3HAV ATP 0.00066 0.45846
506 2WXG ZZN 0.0009193 0.45691
507 4ORK GDP 0.00014 0.45672
508 3VOT ADP 0.0001348 0.4557
509 3TDV GDP 0.0004103 0.45539
510 3MVH WFE 0.0000003237 0.45494
511 4IWD 1JC 0.000001231 0.45351
512 2OXY K17 0.0000005787 0.45306
513 4UWH JXM 0.0008089 0.4519
514 1OBD ATP 0.001172 0.44945
515 3LQV ADE 0.00352 0.44903
516 3TDV GDP 0.0005779 0.44891
517 1I7L ATP 0.00009063 0.44888
518 1I7L ATP 0.00009063 0.44888
519 1XKK FMM 0.0000004256 0.44871
520 3VOT ADP 0.0002257 0.44799
521 2HGS ADP 0.0009498 0.44772
522 2OXY K17 0.0000009653 0.44687
523 1JPA ANP 0.0000001309 0.44654
524 1EHI ADP 0.0004778 0.44536
525 4AZW ATP 0.001088 0.44119
526 1M0W ANP 0.0005143 0.44053
527 2R7K AMZ 0.002163 0.43991
528 2R7K ACP 0.002163 0.43991
529 3HAV ATP 0.00006169 0.43932
530 1JPA ANP 0.00000003175 0.4392
531 2YW2 ATP 0.0004806 0.43897
532 3QBC B55 0.003611 0.43894
533 3AB4 THR 0.003173 0.4389
534 2BPM 529 0.000000002054 0.43861
535 3QBC B55 0.003679 0.43807
536 2BPM 529 0.000000006441 0.43787
537 3DNT ATP 0.001763 0.43751
538 3PN1 IVH 0.0001393 0.43714
539 4GLW 0XT 0.00351 0.43673
540 2YW2 ATP 0.0005893 0.43547
541 3WAR NIO 0.0000003554 0.43534
542 3SG8 TOY 0.00002423 0.43503
543 3SG8 TOY 0.00002423 0.43503
544 3TY5 ADP 0.001962 0.43433
545 3TII ANP 0.0003342 0.43433
546 3ORQ ADP 0.0006354 0.43337
547 2IO8 ADP 0.0001991 0.43293
548 4CC5 L5V 0.0002928 0.4324
549 1CKM GTP 0.00442 0.43181
550 1CKM GTP 0.00442 0.43181
551 2Z49 AMG 0.006576 0.43028
552 2QK4 ATP 0.0003615 0.43011
553 2C5U APC 0.000721 0.42954
554 4C2W ANP 0.000162 0.42936
555 3PFF ADP 0.002037 0.42921
556 3PFF ADP 0.002037 0.42921
557 1CKN GTP 0.005189 0.42838
558 1CKN GTP 0.005189 0.42838
559 1CKN GTP 0.005189 0.42838
560 1S68 AMP 0.0001852 0.42823
561 4FCH GLC GLC GLC GLC GLC GLC GLC 0.005316 0.42796
562 2C5U APC 0.001191 0.42748
563 4FE2 ADP 0.003523 0.42709
564 3LQV ADE 0.006747 0.42552
565 2DTJ THR 0.004852 0.42505
566 2DTJ THR 0.004852 0.42505
567 3AB4 THR 0.005216 0.42355
568 3AB4 THR 0.005254 0.42339
569 4JPS 1LT 0.003116 0.42097
570 2GQS ADP 0.00198 0.42089
571 2R85 AMP 0.006898 0.41951
572 2AQX ATP 0.0009994 0.41887
573 4O2B ACP 0.001995 0.41861
574 1RZ1 NAD 0.01149 0.41756
575 2GQR ADP 0.002402 0.41722
576 1TZD ADP 0.00005023 0.41698
577 2WTX VDO 0.01108 0.41687
578 3BP1 GUN 0.01571 0.41645
579 3BP1 GUN 0.01571 0.41645
580 2XEG CI9 0.02378 0.41645
581 2WTX UDP 0.01076 0.4164
582 1Q8A HCS 0.01198 0.41579
583 3R4S SIA 0.009636 0.4154
584 3BOF HCS 0.013 0.41393
585 2Z48 A2G 0.01208 0.41348
586 3K5I ADP 0.002116 0.41329
587 3V4S ATP 0.001569 0.41328
588 2Q7D ANP 0.0007542 0.41323
589 4MA7 P2Z 0.02096 0.41286
590 2R85 AMP 0.00962 0.41282
591 1E4E ADP 0.004373 0.41259
592 1RZ1 NAD 0.01404 0.41254
593 1U6R IOM 0.0122 0.41149
594 4PZ6 GMP 0.0001951 0.4105
595 4AXD ANP 0.00001511 0.4103
596 3QBC B55 0.01622 0.41
597 2Z48 A2G 0.01417 0.4093
598 2FP4 GTP 0.003781 0.40908
599 3PDQ KC6 0.01755 0.4084
600 3VSV XYS 0.01826 0.40825
601 2GCG DGY 0.009358 0.40821
602 2QF7 AGS 0.009985 0.40808
603 3SJK LYS PRO VAL LEU ARG THR ALA 0.01778 0.40727
604 3R4S SIA 0.01278 0.40717
605 2I0D MUT 0.04217 0.40697
606 1RZ1 NAD 0.01789 0.40643
607 1C1L GAL BGC 0.018 0.40559
608 1GPM AMP 0.02862 0.40531
609 3B6R CRN 0.007038 0.40529
610 2QK4 ATP 0.001524 0.40514
611 1RZ1 NAD 0.01904 0.40494
612 2GCG DGY 0.01021 0.40464
613 2B4B B33 0.02439 0.40347
614 2Q7D ANP 0.0007158 0.40317
615 2Q7D ANP 0.0007158 0.40317
616 4CS9 AMP 0.009006 0.40251
617 4PU5 ANP 0.002065 0.40216
618 3W0O ADP 0.0004482 0.40149
619 3U6H 03X 0.00003196 0.40135
620 2Z48 NGA 0.01429 0.40062
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