Receptor
PDB id Resolution Class Description Source Keywords
3fu5 2.3 Å EC: 3.3.2.6 LEUKOTRIENE A4 HYDROLASE IN COMPLEX WITH (5-THIOPHEN-2-YLTHI YL)METHYLAMINE HOMO SAPIENS LEUKOTRIENE A4 HYDROLASE LTA4H FRAGMENT CRYSTALLOGRAPHY FOF LIFE FOL ALTERNATIVE SPLICING CYTOPLASM HYDROLASE LEUKOTRIENE BIOSYNTHESIS METAL-BINDING METALLOPROTEASE MULTIFUNCTIONAL ENZYME POLYMORPHISM PROTEASE ZINC
Ref.: DISCOVERY OF LEUKOTRIENE A4 HYDROLASE INHIBITORS US METABOLOMICS BIASED FRAGMENT CRYSTALLOGRAPHY. J.MED.CHEM. V. 52 4694 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
492 A:710;
 Valid;
 none;
 ic50 = 75.2 uM
195.304 C9 H9 N S2 c1cc(...
ACT A:801;
 Invalid;
 none;
 submit data
59.044 C2 H3 O2 CC(=O...
IMD A:802;
A:803;
 Invalid;
Invalid;
 none;
none;
 submit data
69.085 C3 H5 N2 c1c[n...
YB A:702;
 Invalid;
 none;
 submit data
173.04 Yb [Yb+3...
ZN A:701;
 Part of Protein;
 none;
 submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2VJ8 1.8 Å EC: 3.3.2.6 COMPLEX OF HUMAN LEUKOTRIENE A4 HYDROLASE WITH A HYDROXAMIC INHIBITOR HOMO SAPIENS HYDROXAMIC ACID LEUKOTRIENE HYDROLASE ZINC PROTEASE HYDRMETALLOPROTEASE
Ref.: CRYSTAL STRUCTURES OF LEUKOTRIENE A4 HYDROLASE IN C WITH CAPTOPRIL AND TWO COMPETITIVE TIGHT-BINDING IN FASEB J. V. 16 1648 2002
Members (48)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 3FTW - 11X C12 H12 N2 c1ccc(cc1)....
2 3FUK ic50 = 966 uM 58Z C16 H20 N2 O3 c1cc2c(cc[....
3 3FU6 ic50 = 106 uM 80G C11 H11 N S c1cc(sc1)c....
4 6END ic50 = 0.133 uM BGK C13 H8 N2 O2 S c1cc2c(nc1....
5 3FUI ic50 = 0.157 uM 812 C18 H22 N2 O c1ccc(cc1)....
6 3FU5 ic50 = 75.2 uM 492 C9 H9 N S2 c1cc(sc1)c....
7 2R59 Ki = 6.5 nM PH0 C27 H31 N2 O5 P c1ccc(cc1)....
8 5N3W ic50 = 0.5 uM 8KW C15 H16 O3 COc1cc(cc(....
9 3CHP ic50 = 5400 nM 4BO C17 H18 N2 O4 c1ccc(cc1)....
10 4L2L Ki = 2.3 uM 1V6 C16 H14 N2 S c1ccc(cc1)....
11 1HS6 - BES C16 H24 N2 O4 CC(C)C[C@@....
12 6ENB - PRO GLY PRO n/a n/a
13 3B7T - ARG ALA ARG n/a n/a
14 3B7R Ki = 20 nM BIR C21 H27 N2 O5 P C[C@@H](C(....
15 3FUN ic50 = 0.189 uM 798 C22 H21 N O2 S c1cc(ccc1c....
16 3FTX - BES C16 H24 N2 O4 CC(C)C[C@@....
17 5NI4 - DJ3 C20 H30 O3 CCCCC/C=CC....
18 3CHR ic50 = 61 nM 4BS C17 H20 N2 O2 c1ccc(cc1)....
19 3B7S - ARG SER ARG n/a n/a
20 2VJ8 Ki = 0.002 uM HA2 C22 H28 N2 O5 c1ccc(cc1)....
21 3FUH - BES C16 H24 N2 O4 CC(C)C[C@@....
22 5AEN ic50 = 0.06 uM DP8 C16 H19 N O2 CN(C)CCOc1....
23 4MS6 - 28T C13 H20 N2 O4 C1C[C@H](N....
24 3FUE ic50 = 1510 uM 11S C8 H6 Cl N c1cc2c(cc[....
25 3FH8 ic50 = 180 nM 27P C19 H23 N O c1ccc(cc1)....
26 5BPP ic50 = 15.86 uM A4Z C12 H17 N O3 CCCCOc1ccc....
27 3FTZ - 848 C12 H12 N2 O c1ccc(c(c1....
28 5NI6 - DJ3 C20 H30 O3 CCCCC/C=CC....
29 3FTV ic50 = 1667 uM 11X C12 H12 N2 c1ccc(cc1)....
30 3CHQ ic50 = 20 nM 4BQ C18 H20 N2 O4 c1ccc(cc1)....
31 3FUL ic50 = 199 uM 52D C18 H20 N2 O2 c1cc(ccc1C....
32 3FTS ic50 = 212 uM STL C14 H12 O3 c1cc(ccc1C....
33 3FHE - 28P C20 H25 N O3 C[N@@](CCC....
34 6ENC ic50 = 0.019 uM BGW C20 H20 N2 O3 S c1ccc2c(c1....
35 3FUM ic50 = 170 uM 80A C18 H22 N2 O2 c1cc(ccc1[....
36 3B7U - KEL C14 H18 N2 O5 C[C@@H](C(....
37 3FTY ic50 = 619 uM 3IP C12 H12 N2 O c1ccc(cc1)....
38 3FTU ic50 = 247 uM RE2 C14 H14 O3 c1cc(ccc1C....
39 3FH7 Kd = 25 nM 25P C21 H23 Cl N O4 c1cc(ccc1O....
40 3FUJ ic50 = 234 uM 00G C14 H14 N2 O c1ccn(c1)C....
41 3FU0 ic50 = 5308 uM 22F C12 H8 F N O c1cc(ccc1C....
42 3FH5 ic50 = 87 nM 24P C18 H21 N O c1ccc(cc1)....
43 3CHO ic50 = 280 nM 4BG C15 H16 N2 O2 c1ccc(cc1)....
44 3FUD ic50 > 2000 uM 692 C12 H13 N S CNCc1ccccc....
45 3FU3 ic50 = 1443 uM 92G C9 H8 N2 O S c1cc(ccc1c....
46 4MKT Ki = 2.3 uM 1V6 C16 H14 N2 S c1ccc(cc1)....
47 5NI2 - DJ3 C20 H30 O3 CCCCC/C=CC....
48 1GW6 - BES C16 H24 N2 O4 CC(C)C[C@@....
70% Homology Family (49)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 3FTW - 11X C12 H12 N2 c1ccc(cc1)....
2 3FUK ic50 = 966 uM 58Z C16 H20 N2 O3 c1cc2c(cc[....
3 3FU6 ic50 = 106 uM 80G C11 H11 N S c1cc(sc1)c....
4 6END ic50 = 0.133 uM BGK C13 H8 N2 O2 S c1cc2c(nc1....
5 3FUI ic50 = 0.157 uM 812 C18 H22 N2 O c1ccc(cc1)....
6 3FU5 ic50 = 75.2 uM 492 C9 H9 N S2 c1cc(sc1)c....
7 2R59 Ki = 6.5 nM PH0 C27 H31 N2 O5 P c1ccc(cc1)....
8 5N3W ic50 = 0.5 uM 8KW C15 H16 O3 COc1cc(cc(....
9 3CHP ic50 = 5400 nM 4BO C17 H18 N2 O4 c1ccc(cc1)....
10 4L2L Ki = 2.3 uM 1V6 C16 H14 N2 S c1ccc(cc1)....
11 1HS6 - BES C16 H24 N2 O4 CC(C)C[C@@....
12 6ENB - PRO GLY PRO n/a n/a
13 3B7T - ARG ALA ARG n/a n/a
14 3B7R Ki = 20 nM BIR C21 H27 N2 O5 P C[C@@H](C(....
15 3FUN ic50 = 0.189 uM 798 C22 H21 N O2 S c1cc(ccc1c....
16 3FTX - BES C16 H24 N2 O4 CC(C)C[C@@....
17 5NI4 - DJ3 C20 H30 O3 CCCCC/C=CC....
18 3CHR ic50 = 61 nM 4BS C17 H20 N2 O2 c1ccc(cc1)....
19 3B7S - ARG SER ARG n/a n/a
20 2VJ8 Ki = 0.002 uM HA2 C22 H28 N2 O5 c1ccc(cc1)....
21 3FUH - BES C16 H24 N2 O4 CC(C)C[C@@....
22 5AEN ic50 = 0.06 uM DP8 C16 H19 N O2 CN(C)CCOc1....
23 4MS6 - 28T C13 H20 N2 O4 C1C[C@H](N....
24 3FUE ic50 = 1510 uM 11S C8 H6 Cl N c1cc2c(cc[....
25 3FH8 ic50 = 180 nM 27P C19 H23 N O c1ccc(cc1)....
26 5BPP ic50 = 15.86 uM A4Z C12 H17 N O3 CCCCOc1ccc....
27 3FTZ - 848 C12 H12 N2 O c1ccc(c(c1....
28 5NI6 - DJ3 C20 H30 O3 CCCCC/C=CC....
29 3FTV ic50 = 1667 uM 11X C12 H12 N2 c1ccc(cc1)....
30 3CHQ ic50 = 20 nM 4BQ C18 H20 N2 O4 c1ccc(cc1)....
31 3FUL ic50 = 199 uM 52D C18 H20 N2 O2 c1cc(ccc1C....
32 3FTS ic50 = 212 uM STL C14 H12 O3 c1cc(ccc1C....
33 3FHE - 28P C20 H25 N O3 C[N@@](CCC....
34 6ENC ic50 = 0.019 uM BGW C20 H20 N2 O3 S c1ccc2c(c1....
35 3FUM ic50 = 170 uM 80A C18 H22 N2 O2 c1cc(ccc1[....
36 3B7U - KEL C14 H18 N2 O5 C[C@@H](C(....
37 3FTY ic50 = 619 uM 3IP C12 H12 N2 O c1ccc(cc1)....
38 3FTU ic50 = 247 uM RE2 C14 H14 O3 c1cc(ccc1C....
39 3FH7 Kd = 25 nM 25P C21 H23 Cl N O4 c1cc(ccc1O....
40 3FUJ ic50 = 234 uM 00G C14 H14 N2 O c1ccn(c1)C....
41 3FU0 ic50 = 5308 uM 22F C12 H8 F N O c1cc(ccc1C....
42 3FH5 ic50 = 87 nM 24P C18 H21 N O c1ccc(cc1)....
43 3CHO ic50 = 280 nM 4BG C15 H16 N2 O2 c1ccc(cc1)....
44 3FUD ic50 > 2000 uM 692 C12 H13 N S CNCc1ccccc....
45 3FU3 ic50 = 1443 uM 92G C9 H8 N2 O S c1cc(ccc1c....
46 4MKT Ki = 2.3 uM 1V6 C16 H14 N2 S c1ccc(cc1)....
47 5NI2 - DJ3 C20 H30 O3 CCCCC/C=CC....
48 1GW6 - BES C16 H24 N2 O4 CC(C)C[C@@....
49 4GAA - BES C16 H24 N2 O4 CC(C)C[C@@....
50% Homology Family (50)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 3FTW - 11X C12 H12 N2 c1ccc(cc1)....
2 3FUK ic50 = 966 uM 58Z C16 H20 N2 O3 c1cc2c(cc[....
3 3FU6 ic50 = 106 uM 80G C11 H11 N S c1cc(sc1)c....
4 6END ic50 = 0.133 uM BGK C13 H8 N2 O2 S c1cc2c(nc1....
5 3FUI ic50 = 0.157 uM 812 C18 H22 N2 O c1ccc(cc1)....
6 3FU5 ic50 = 75.2 uM 492 C9 H9 N S2 c1cc(sc1)c....
7 2R59 Ki = 6.5 nM PH0 C27 H31 N2 O5 P c1ccc(cc1)....
8 5N3W ic50 = 0.5 uM 8KW C15 H16 O3 COc1cc(cc(....
9 3CHP ic50 = 5400 nM 4BO C17 H18 N2 O4 c1ccc(cc1)....
10 4L2L Ki = 2.3 uM 1V6 C16 H14 N2 S c1ccc(cc1)....
11 1HS6 - BES C16 H24 N2 O4 CC(C)C[C@@....
12 6ENB - PRO GLY PRO n/a n/a
13 3B7T - ARG ALA ARG n/a n/a
14 3B7R Ki = 20 nM BIR C21 H27 N2 O5 P C[C@@H](C(....
15 3FUN ic50 = 0.189 uM 798 C22 H21 N O2 S c1cc(ccc1c....
16 3FTX - BES C16 H24 N2 O4 CC(C)C[C@@....
17 5NI4 - DJ3 C20 H30 O3 CCCCC/C=CC....
18 3CHR ic50 = 61 nM 4BS C17 H20 N2 O2 c1ccc(cc1)....
19 3B7S - ARG SER ARG n/a n/a
20 2VJ8 Ki = 0.002 uM HA2 C22 H28 N2 O5 c1ccc(cc1)....
21 3FUH - BES C16 H24 N2 O4 CC(C)C[C@@....
22 5AEN ic50 = 0.06 uM DP8 C16 H19 N O2 CN(C)CCOc1....
23 4MS6 - 28T C13 H20 N2 O4 C1C[C@H](N....
24 3FUE ic50 = 1510 uM 11S C8 H6 Cl N c1cc2c(cc[....
25 3FH8 ic50 = 180 nM 27P C19 H23 N O c1ccc(cc1)....
26 5BPP ic50 = 15.86 uM A4Z C12 H17 N O3 CCCCOc1ccc....
27 3FTZ - 848 C12 H12 N2 O c1ccc(c(c1....
28 5NI6 - DJ3 C20 H30 O3 CCCCC/C=CC....
29 3FTV ic50 = 1667 uM 11X C12 H12 N2 c1ccc(cc1)....
30 3CHQ ic50 = 20 nM 4BQ C18 H20 N2 O4 c1ccc(cc1)....
31 3FUL ic50 = 199 uM 52D C18 H20 N2 O2 c1cc(ccc1C....
32 3FTS ic50 = 212 uM STL C14 H12 O3 c1cc(ccc1C....
33 3FHE - 28P C20 H25 N O3 C[N@@](CCC....
34 6ENC ic50 = 0.019 uM BGW C20 H20 N2 O3 S c1ccc2c(c1....
35 3FUM ic50 = 170 uM 80A C18 H22 N2 O2 c1cc(ccc1[....
36 3B7U - KEL C14 H18 N2 O5 C[C@@H](C(....
37 3FTY ic50 = 619 uM 3IP C12 H12 N2 O c1ccc(cc1)....
38 3FTU ic50 = 247 uM RE2 C14 H14 O3 c1cc(ccc1C....
39 3FH7 Kd = 25 nM 25P C21 H23 Cl N O4 c1cc(ccc1O....
40 3FUJ ic50 = 234 uM 00G C14 H14 N2 O c1ccn(c1)C....
41 3FU0 ic50 = 5308 uM 22F C12 H8 F N O c1cc(ccc1C....
42 3FH5 ic50 = 87 nM 24P C18 H21 N O c1ccc(cc1)....
43 3CHO ic50 = 280 nM 4BG C15 H16 N2 O2 c1ccc(cc1)....
44 3FUD ic50 > 2000 uM 692 C12 H13 N S CNCc1ccccc....
45 3FU3 ic50 = 1443 uM 92G C9 H8 N2 O S c1cc(ccc1c....
46 4MKT Ki = 2.3 uM 1V6 C16 H14 N2 S c1ccc(cc1)....
47 5NI2 - DJ3 C20 H30 O3 CCCCC/C=CC....
48 1GW6 - BES C16 H24 N2 O4 CC(C)C[C@@....
49 4GAA - BES C16 H24 N2 O4 CC(C)C[C@@....
50 2XQ0 - BES C16 H24 N2 O4 CC(C)C[C@@....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 492; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 492 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: 492; Similar ligands found: 616
No: Ligand Similarity coefficient
1 0NX 0.9738
2 RA7 0.9717
3 D3G 0.9653
4 IWT 0.9611
5 J9N 0.9579
6 G14 0.9574
7 F4K 0.9570
8 7O4 0.9511
9 R20 0.9502
10 795 0.9501
11 7VP 0.9462
12 PUE 0.9454
13 JMG 0.9413
14 LEL 0.9405
15 3VQ 0.9400
16 ZZA 0.9400
17 6MW 0.9392
18 HX4 0.9371
19 80G 0.9370
20 N4E 0.9364
21 CPZ 0.9351
22 2QC 0.9334
23 363 0.9329
24 C82 0.9323
25 VM1 0.9313
26 TYL 0.9313
27 MSR 0.9310
28 SNU 0.9308
29 36Y 0.9307
30 HQJ 0.9289
31 L22 0.9286
32 L5V 0.9286
33 KLE 0.9279
34 YZM 0.9277
35 ENO 0.9273
36 FMQ 0.9272
37 A5E 0.9269
38 ODK 0.9267
39 P80 0.9264
40 HNL 0.9261
41 L1T 0.9253
42 2D2 0.9248
43 8NB 0.9247
44 SWX 0.9245
45 60L 0.9242
46 RKV 0.9238
47 X6W 0.9237
48 GVY 0.9229
49 TYR 0.9228
50 RNO 0.9227
51 78Y 0.9223
52 3ZB 0.9221
53 MPV 0.9218
54 NF3 0.9218
55 2FX 0.9202
56 PNZ 0.9200
57 L03 0.9199
58 TZF 0.9197
59 6KT 0.9193
60 5F5 0.9191
61 TT4 0.9186
62 D2G 0.9185
63 PH3 0.9182
64 SNO 0.9182
65 K4V 0.9181
66 GF4 0.9181
67 BNL 0.9177
68 XI7 0.9176
69 TMG 0.9174
70 92G 0.9164
71 4BY 0.9163
72 L15 0.9161
73 PPY 0.9159
74 0LO 0.9150
75 94W 0.9145
76 HC4 0.9144
77 J6W 0.9142
78 C53 0.9141
79 XDK 0.9127
80 CWJ 0.9126
81 HNH 0.9126
82 3C5 0.9125
83 36M 0.9124
84 5TZ 0.9122
85 9FH 0.9119
86 LL1 0.9118
87 ANN 0.9117
88 F4E 0.9112
89 XCG 0.9110
90 NAG 0.9109
91 OQC 0.9109
92 UNJ 0.9108
93 CK2 0.9108
94 S7S 0.9104
95 4BZ 0.9101
96 4FF 0.9100
97 A29 0.9095
98 GT4 0.9093
99 3H2 0.9090
100 EWG 0.9090
101 MMJ 0.9086
102 HL4 0.9085
103 2BX 0.9083
104 5H6 0.9078
105 HDH 0.9077
106 PO6 0.9076
107 P81 0.9076
108 E5X 0.9073
109 AZM 0.9073
110 6FG 0.9070
111 OTR 0.9069
112 K97 0.9068
113 6FB 0.9068
114 JCZ 0.9066
115 SSC 0.9066
116 PBN 0.9065
117 GZ2 0.9064
118 CH9 0.9062
119 4NM 0.9062
120 OHJ 0.9061
121 GO2 0.9059
122 4XF 0.9054
123 DHC 0.9054
124 M1T 0.9049
125 LO1 0.9049
126 EQW 0.9047
127 PFF 0.9046
128 5LA 0.9045
129 JBZ 0.9044
130 0K7 0.9043
131 I3E 0.9041
132 4BL 0.9040
133 N9J 0.9038
134 BZJ 0.9037
135 3VS 0.9037
136 FCD 0.9037
137 SQV 0.9034
138 2F6 0.9034
139 HXY 0.9031
140 1A7 0.9031
141 XIZ 0.9025
142 DVQ 0.9023
143 5XC 0.9020
144 FZM 0.9018
145 8D6 0.9015
146 TCA 0.9014
147 4YO 0.9014
148 428 0.9013
149 ES2 0.9011
150 BPY 0.9010
151 RD4 0.9010
152 BVA 0.9009
153 5F8 0.9007
154 A5H 0.9007
155 7MU 0.9005
156 4I8 0.9002
157 NK5 0.9000
158 8CC 0.9000
159 PCS 0.8999
160 6SD 0.8998
161 Y3L 0.8996
162 FHC 0.8996
163 ALE 0.8993
164 SOJ 0.8993
165 PHE 0.8991
166 AMH 0.8990
167 1F1 0.8990
168 0BP 0.8990
169 LSQ 0.8990
170 LZ5 0.8986
171 5FL 0.8981
172 A98 0.8981
173 EN1 0.8980
174 B1J 0.8979
175 DZA 0.8977
176 A7H 0.8977
177 BVS 0.8976
178 4V2 0.8974
179 KLS 0.8974
180 4AU 0.8974
181 DTY 0.8972
182 AVA 0.8971
183 KMY 0.8969
184 M5H 0.8966
185 EYJ 0.8966
186 259 0.8965
187 M3H 0.8962
188 5OO 0.8960
189 7UC 0.8960
190 14W 0.8959
191 ARG 0.8958
192 DE5 0.8957
193 PIM 0.8956
194 J9T 0.8954
195 0UL 0.8954
196 AOT 0.8951
197 GOJ 0.8950
198 6ZX 0.8950
199 PJW 0.8948
200 OOG 0.8948
201 FTV 0.8948
202 0F9 0.8946
203 0HO 0.8945
204 9R5 0.8945
205 HIC 0.8944
206 4FA 0.8943
207 D8Q 0.8942
208 NFA 0.8941
209 8WO 0.8940
210 TB8 0.8940
211 4Z3 0.8940
212 3A9 0.8937
213 VFG 0.8937
214 3YP 0.8935
215 TYE 0.8934
216 ESX 0.8934
217 6P3 0.8931
218 BZ2 0.8931
219 0HN 0.8930
220 HHH 0.8929
221 6NT 0.8929
222 7OD 0.8929
223 HPP 0.8928
224 AKG 0.8928
225 PQS 0.8927
226 AES 0.8927
227 BP7 0.8927
228 X48 0.8926
229 6C8 0.8925
230 6XA 0.8925
231 X0U 0.8925
232 I2E 0.8920
233 YE6 0.8919
234 EE8 0.8919
235 A7Q 0.8918
236 PKU 0.8918
237 JRB 0.8918
238 T2D 0.8916
239 1P8 0.8916
240 M4N 0.8915
241 VC3 0.8915
242 5GU 0.8914
243 011 0.8913
244 C1M 0.8913
245 6TZ 0.8912
246 ACA 0.8912
247 DIR 0.8911
248 A6W 0.8910
249 GVG 0.8909
250 IOP 0.8909
251 OGA 0.8906
252 NCT 0.8906
253 ONR 0.8906
254 7BC 0.8905
255 1L5 0.8903
256 CIR 0.8902
257 SB7 0.8902
258 QIV 0.8901
259 HIS 0.8901
260 HJ7 0.8899
261 KDG 0.8897
262 OCA 0.8894
263 E7S 0.8893
264 LFQ 0.8892
265 HJH 0.8892
266 E79 0.8891
267 JAH 0.8890
268 2HC 0.8890
269 AG2 0.8889
270 B40 0.8889
271 49P 0.8888
272 TJM 0.8888
273 SSB 0.8888
274 A7N 0.8887
275 BQ2 0.8885
276 MS9 0.8882
277 M45 0.8881
278 N3W 0.8879
279 A9B 0.8878
280 K82 0.8878
281 EOU 0.8877
282 2BG 0.8875
283 4LW 0.8875
284 TIH 0.8873
285 K80 0.8872
286 BZQ 0.8872
287 4LV 0.8871
288 XOG 0.8871
289 TEG 0.8870
290 P7Y 0.8869
291 549 0.8868
292 MD6 0.8868
293 61M 0.8868
294 6C4 0.8868
295 LQ2 0.8867
296 D1G 0.8864
297 X1R 0.8862
298 ESP 0.8861
299 AJG 0.8860
300 J9Q 0.8859
301 64Z 0.8858
302 TCR 0.8858
303 7MW 0.8857
304 2O8 0.8857
305 QUS 0.8855
306 HNK 0.8855
307 PRL 0.8854
308 9NB 0.8854
309 EYV 0.8854
310 LLH 0.8854
311 15E 0.8853
312 4JQ 0.8852
313 6FZ 0.8852
314 TRP 0.8852
315 3QV 0.8850
316 27K 0.8849
317 5RP 0.8849
318 FF2 0.8847
319 HNE 0.8847
320 GNW 0.8847
321 PPT 0.8846
322 GRQ 0.8844
323 6C9 0.8844
324 4WL 0.8844
325 PIY 0.8843
326 2ZM 0.8842
327 S0E 0.8842
328 ERZ 0.8842
329 4NB 0.8839
330 EUE 0.8837
331 3VW 0.8837
332 GGB 0.8836
333 5C1 0.8835
334 E4P 0.8833
335 M5E 0.8832
336 U7E 0.8831
337 JA8 0.8830
338 069 0.8826
339 4NP 0.8826
340 FUD 0.8826
341 Q06 0.8826
342 9UL 0.8825
343 YRL 0.8824
344 TYC 0.8822
345 P93 0.8822
346 S0W 0.8821
347 KJU 0.8821
348 HRM 0.8820
349 YPN 0.8819
350 AHN 0.8819
351 NFM 0.8818
352 N2I 0.8818
353 2HG 0.8815
354 CK1 0.8815
355 L14 0.8812
356 88L 0.8811
357 833 0.8811
358 GVA 0.8811
359 9ZE 0.8810
360 0JD 0.8808
361 12T 0.8807
362 ABI 0.8807
363 H4E 0.8804
364 N2Z 0.8804
365 5TO 0.8803
366 D9Z 0.8801
367 HSO 0.8801
368 1XS 0.8800
369 4TB 0.8800
370 3R4 0.8800
371 HCI 0.8799
372 4G2 0.8798
373 2PV 0.8797
374 6HO 0.8797
375 650 0.8797
376 GLU 0.8796
377 11C 0.8794
378 HHI 0.8793
379 1PS 0.8792
380 ENW 0.8791
381 BSA 0.8790
382 4BX 0.8787
383 37E 0.8787
384 EQA 0.8786
385 SQ7 0.8786
386 1VK 0.8785
387 CFA 0.8785
388 YTX 0.8784
389 SOR 0.8784
390 LNR 0.8783
391 PRO GLY 0.8783
392 JB8 0.8782
393 MHN 0.8781
394 6N4 0.8781
395 M4S 0.8781
396 KDV 0.8780
397 K48 0.8779
398 BL0 0.8778
399 M1Z 0.8778
400 AJ1 0.8776
401 P7V 0.8776
402 NGA 0.8776
403 FER 0.8774
404 CXH 0.8773
405 8SZ 0.8773
406 FDR 0.8770
407 28A 0.8765
408 GWM 0.8765
409 4MB 0.8764
410 0SY 0.8763
411 AUV 0.8762
412 2PK 0.8761
413 8NX 0.8761
414 SPD 0.8760
415 5E5 0.8758
416 LDP 0.8757
417 4BF 0.8757
418 92P 0.8757
419 TOH 0.8757
420 V2Z 0.8757
421 JDN 0.8756
422 ZEC 0.8756
423 6C5 0.8755
424 VFM 0.8755
425 9FL 0.8753
426 1A5 0.8753
427 S2G 0.8752
428 6NI 0.8752
429 SLS 0.8751
430 15N 0.8751
431 C4E 0.8749
432 A5P 0.8749
433 SSY 0.8748
434 IOS 0.8748
435 GLO 0.8747
436 4NS 0.8743
437 0W1 0.8743
438 DHI 0.8741
439 B21 0.8741
440 3OM 0.8740
441 344 0.8740
442 1Z6 0.8740
443 Q4G 0.8739
444 LGT 0.8738
445 0L1 0.8737
446 URO 0.8737
447 5O6 0.8737
448 5NI 0.8737
449 OW7 0.8736
450 8YH 0.8734
451 6L6 0.8733
452 N1E 0.8732
453 P4L 0.8730
454 1X4 0.8730
455 EGV 0.8727
456 M4E 0.8726
457 TIA 0.8725
458 PQM 0.8725
459 5TT 0.8725
460 1FD 0.8724
461 UN1 0.8720
462 KYN 0.8718
463 L99 0.8716
464 ICB 0.8715
465 5DL 0.8714
466 5B2 0.8714
467 CS2 0.8714
468 OC9 0.8713
469 3W8 0.8712
470 KMH 0.8712
471 M3P 0.8711
472 AMR 0.8710
473 6Q3 0.8709
474 3NY 0.8707
475 HNT 0.8706
476 S2P 0.8706
477 E3X 0.8705
478 CSN 0.8704
479 L5D 0.8703
480 BGU 0.8703
481 DAH 0.8701
482 BIK 0.8698
483 1OS 0.8697
484 VBC 0.8696
485 S0D 0.8695
486 JSX 0.8695
487 GB5 0.8695
488 S1D 0.8695
489 9BF 0.8695
490 KW8 0.8693
491 R52 0.8693
492 MZM 0.8690
493 5TY 0.8690
494 VGD 0.8690
495 AN3 0.8690
496 0ON 0.8690
497 AEG 0.8689
498 MTL 0.8686
499 LYS 0.8686
500 MAJ 0.8686
501 3VX 0.8685
502 OA1 0.8684
503 RCV 0.8684
504 DER 0.8683
505 Q04 0.8683
506 DXK 0.8681
507 GLN 0.8680
508 4HB 0.8680
509 A6Z 0.8680
510 N91 0.8679
511 Z70 0.8679
512 IQ5 0.8677
513 F63 0.8677
514 8ZE 0.8675
515 NMM 0.8673
516 68B 0.8673
517 C0H 0.8673
518 5GT 0.8673
519 2GQ 0.8673
520 5VL 0.8673
521 R5P 0.8672
522 ST3 0.8669
523 268 0.8669
524 7UZ 0.8664
525 ENV 0.8663
526 E1T 0.8663
527 3XH 0.8662
528 BZE 0.8662
529 JP2 0.8661
530 3W6 0.8660
531 3W3 0.8660
532 HL6 0.8660
533 N7I 0.8659
534 MVH 0.8659
535 2UZ 0.8656
536 O45 0.8655
537 OW4 0.8652
538 FBB 0.8651
539 K2T 0.8650
540 ATX 0.8648
541 DEW 0.8646
542 4FP 0.8646
543 TAG 0.8643
544 QME 0.8643
545 VGS 0.8641
546 NFZ 0.8640
547 1IT 0.8640
548 MQN 0.8640
549 II4 0.8640
550 PHI 0.8637
551 4FE 0.8635
552 0F3 0.8635
553 N6C 0.8634
554 ONH 0.8632
555 IPO 0.8632
556 NDG 0.8632
557 9CA 0.8631
558 IAC 0.8631
559 OVM 0.8631
560 E0O 0.8629
561 3D8 0.8626
562 J1K 0.8625
563 3OL 0.8624
564 SZ7 0.8623
565 TU0 0.8622
566 HH6 0.8621
567 LR2 0.8621
568 FQX 0.8620
569 C2Y 0.8619
570 36R 0.8610
571 CLW 0.8610
572 FCW 0.8610
573 PML 0.8608
574 8XL 0.8606
575 SQ4 0.8606
576 1ZC 0.8603
577 HWD 0.8603
578 54X 0.8598
579 SKF 0.8596
580 K3D 0.8593
581 S8V 0.8593
582 DEZ 0.8593
583 API 0.8592
584 HBO 0.8592
585 DGL 0.8591
586 DHR 0.8590
587 DRG 0.8590
588 9GB 0.8590
589 LJ3 0.8590
590 0FR 0.8588
591 NWH 0.8586
592 2HU 0.8583
593 S60 0.8581
594 F40 0.8580
595 0TU 0.8580
596 OVP 0.8574
597 3SU 0.8570
598 TID 0.8568
599 4VY 0.8567
600 DJN 0.8564
601 58X 0.8563
602 STT 0.8561
603 PNP 0.8560
604 ANC 0.8560
605 11X 0.8557
606 JF5 0.8557
607 PD2 0.8555
608 MXD 0.8551
609 W81 0.8550
610 DXP 0.8546
611 2UD 0.8545
612 THA 0.8544
613 GJK 0.8532
614 5VM 0.8530
615 5DS 0.8523
616 657 0.8519
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2VJ8; Ligand: HA2; Similar sites found with APoc: 1
This union binding pocket(no: 1) in the query (biounit: 2vj8.bio1) has 40 residues
No: Leader PDB Ligand Sequence Similarity
1 6Q4R HJ5 24.5499
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