Receptor
PDB id Resolution Class Description Source Keywords
3WUD 1.68 Å NON-ENZYME: BINDING X-RAY CRYSTAL STRUCTURE OF XENOPUS LAEVIS GALECTIN-IB XENOPUS LAEVIS BETA-SANDWICH LECTIN CARBOHYDRATE/SUGAR BINDING SUGAR BINPROTEIN
Ref.: CRYSTAL STRUCTURE OF A XENOPUS LAEVIS SKIN PROTO-TY GALECTIN, CLOSE TO BUT DISTINCT FROM GALECTIN-1 GLYCOBIOLOGY 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SO4 A:203;
Invalid;
none;
submit data
96.063 O4 S [O-]S...
GLC GAL B:1;
Valid;
none;
Kd = 41 uM
n/a n/a
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3WUD 1.68 Å NON-ENZYME: BINDING X-RAY CRYSTAL STRUCTURE OF XENOPUS LAEVIS GALECTIN-IB XENOPUS LAEVIS BETA-SANDWICH LECTIN CARBOHYDRATE/SUGAR BINDING SUGAR BINPROTEIN
Ref.: CRYSTAL STRUCTURE OF A XENOPUS LAEVIS SKIN PROTO-TY GALECTIN, CLOSE TO BUT DISTINCT FROM GALECTIN-1 GLYCOBIOLOGY 2015
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 552 families.
1 3WUD Kd = 41 uM GLC GAL n/a n/a
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 426 families.
1 3WUD Kd = 41 uM GLC GAL n/a n/a
2 1GAN - NDG GAL n/a n/a
3 1A78 - YIO GAL n/a n/a
50% Homology Family (141)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 322 families.
1 5NF9 Kd = 4.7 uM 8VW C22 H32 N2 O12 CC(=O)N[C@....
2 6Y78 - BGC GAL n/a n/a
3 5E8A Kd = 0.034 uM 5KS C28 H30 F2 N6 O8 S c1cc(ccc1c....
4 6QLQ Kd = 31 uM J4E C21 H22 F N3 O4 S Cc1ccc(cc1....
5 1A3K - NAG GAL n/a n/a
6 3T1M Kd = 0.91 mM DQT C23 H27 N O7 Cc1ccc(cc1....
7 6RHM - J1E C25 H26 F2 N6 O5 S c1cc(cc(c1....
8 6Q0Q Kd = 535 mM P8G C25 H40 N6 O16 CO[C@H]1[C....
9 4LBL Kd = 11 uM BGC GAL SIA n/a n/a
10 6I77 Kd = 11 uM H5Q C21 H20 F4 N4 O4 S Cc1ccc(cc1....
11 6Y4C - BGC GAL n/a n/a
12 2NMN Kd = 260 uM BGC GAL n/a n/a
13 4R9B - BGC GAL n/a n/a
14 6RHL - J0T C25 H26 F2 N6 O5 S c1cc(cc(c1....
15 2NN8 Kd = 260 uM BGC GAL n/a n/a
16 6QLP Kd = 22 uM J3Q C21 H20 F3 N3 O4 S Cc1ccc(cc1....
17 4JC1 Kd = 50 uM YIO GAL n/a n/a
18 4R9A - BGC GAL n/a n/a
19 6QLS Kd = 15 uM HRK C20 H27 N3 O9 S c1ccc(cc1)....
20 5EXO - 5SY C19 H22 O9 CC(=O)O[C@....
21 5ODY Kd = 4 nM 9SK C30 H28 F5 N3 O11 S c1cc(c(c2c....
22 5E88 Kd = 0.065 uM 5KT C24 H28 N6 O8 S3 c1cscc1c2c....
23 4R9D - BGC GAL n/a n/a
24 6QLR Kd = 8.8 uM J4N C21 H21 F2 N3 O4 S Cc1ccc(cc1....
25 1KJL Kd = 67 uM NAG GAL n/a n/a
26 6QLU Kd = 5.2 uM J62 C22 H24 F N3 O4 S Cc1ccc(cc1....
27 3T1L Kd = 0.55 mM MQT C17 H22 O8 Cc1ccc(cc1....
28 2XG3 Kd = 18.2 uM NAG GAL UNU n/a n/a
29 4LBJ Kd = 0.39 uM BGC GAL NAG GAL n/a n/a
30 6QLN Kd = 88 uM J5Q C21 H22 F N3 O4 S Cc1ccc(cc1....
31 4R9C - BGC GAL n/a n/a
32 6I74 Kd = 3.4 uM H5Z C21 H18 F5 N3 O4 S Cc1ccc(cc1....
33 3ZSJ Kd = 231 uM BGC GAL n/a n/a
34 4LBM Kd = 0.97 uM BGC GAL NAG GAL n/a n/a
35 1KJR Kd = 0.88 uM NAG GAL BEK n/a n/a
36 6EOL Kd = 0.037 uM BKH C20 H16 Cl2 F3 N3 O4 S c1cc(c(cc1....
37 6KXB Kd ~ 1300 uM GTR ADA ADA n/a n/a
38 6I78 Kd = 18 uM H5H C22 H22 F4 N4 O4 S Cc1ccc(cc1....
39 6Q17 Kd = 972 mM P8J C16 H27 N3 O11 CO[C@H]1[C....
40 6QGE Kd = 0.000000064 M J1E C25 H26 F2 N6 O5 S c1cc(cc(c1....
41 6G0V Kd = 166 uM EGZ C18 H25 N O13 S C1[C@H](NC....
42 3AYE - BGC GAL n/a n/a
43 6QLT Kd = 23 uM J5W C21 H22 F N3 O4 S Cc1ccc(cc1....
44 6EOG Kd = 1.6 uM BKK C20 H17 Cl F3 N3 O4 S c1cc(cc(c1....
45 6KXA Kd ~ 1700 uM GTR ADA n/a n/a
46 5E89 Kd = 0.014 uM TD2 C28 H30 F2 N6 O8 S c1cc(cc(c1....
47 4LBO Kd = 1.7 uM BGC GAL SIA n/a n/a
48 6QGF Kd = 0.000000064 M J0T C25 H26 F2 N6 O5 S c1cc(cc(c1....
49 6I76 Kd = 8.5 uM H5N C21 H18 F4 N6 O4 S Cc1ccc(cc1....
50 2NMO Kd = 260 uM BGC GAL n/a n/a
51 3AYC Kd = 57 uM BGC GAL SIA NGA GAL n/a n/a
52 4JCK Kd = 4.3 mM TWJ SDY n/a n/a
53 5NFA Kd = 5.6 uM TVD TVM n/a n/a
54 4LBK Kd = 0.32 uM BGC GAL NAG GAL n/a n/a
55 5OAX Kd = 27 nM 9Q5 C30 H30 F3 N3 O11 S c1cc(cc(c1....
56 4RL7 - BGC GAL n/a n/a
57 6QLO Kd = 92 uM J5E C21 H21 F2 N3 O4 S Cc1ccc(cc1....
58 3AYD Kd = 65 uM A2G NPO GAL n/a n/a
59 4LBN Kd = 0.65 uM GLC GAL NAG GAL n/a n/a
60 6I75 Kd = 23 uM H5T C21 H19 F4 N3 O5 S Cc1ccc(cc1....
61 6L68 - ALL C6 H12 O6 C([C@@H]1[....
62 1G86 - NEQ C6 H7 N O2 CCN1C(=O)C....
63 6L6C - 64K C5 H10 O5 C1[C@H]([C....
64 6L6B - FUL C6 H12 O5 C[C@H]1[C@....
65 1QKQ - MAN C6 H12 O6 C([C@@H]1[....
66 1HDK - PMB C6 H5 Hg O3 S c1cc(ccc1S....
67 6QRN - RIP C5 H10 O5 C1[C@H]([C....
68 6L64 - BGC C6 H12 O6 C([C@@H]1[....
69 6L6D - NGA C8 H15 N O6 CC(=O)N[C@....
70 2D6N - NAG GAL n/a n/a
71 2D6M - GLC GAL n/a n/a
72 2D6O - NAG GAL NAG GAL n/a n/a
73 4XBN Kd = 93 uM NAG GAL n/a n/a
74 5H9R Kd = 0.84 uM TGZ C20 H26 F N3 O9 S c1cc(cc(c1....
75 5H9P Kd = 0.068 uM TD2 C28 H30 F2 N6 O8 S c1cc(cc(c1....
76 5DG2 - GLC GAL n/a n/a
77 5EWS - BGC GAL n/a n/a
78 5NM1 - GLC GAL n/a n/a
79 5NLD - GLC GAL n/a n/a
80 5NMJ - GLC GAL n/a n/a
81 5NLH - GLC GAL n/a n/a
82 5NLE - GLC GAL n/a n/a
83 4XBL Kd = 340 uM NAG GAL n/a n/a
84 4Y24 Kd = 0.22 uM TD2 C28 H30 F2 N6 O8 S c1cc(cc(c1....
85 3T2T - MQT C17 H22 O8 Cc1ccc(cc1....
86 3OY8 Kd = 220 uM GCO GAL n/a n/a
87 2EAL - GAL NGA A2G n/a n/a
88 2ZHL Kd = 3 uM NAG GAL NAG GAL n/a n/a
89 2ZHK Kd = 3 uM NAG GAL NAG GAL n/a n/a
90 2ZHN - NAG GAL NAG GAL NAG GAL n/a n/a
91 2ZHM - NAG GAL NAG GAL n/a n/a
92 2EAK - GLC GAL n/a n/a
93 3WLU - LSE C18 H36 O10 Se Si C[Si](C)(C....
94 5H9S Kd = 87 uM TGZ C20 H26 F N3 O9 S c1cc(cc(c1....
95 5H9Q Kd = 38 uM TD2 C28 H30 F2 N6 O8 S c1cc(cc(c1....
96 4XBQ Kd = 270 uM NAG GAL n/a n/a
97 6A62 - BGC GAL n/a n/a
98 6A64 - BGC GAL n/a n/a
99 6A63 - BGC GAL n/a n/a
100 5T7S Kd = 3.1 uM GLC GAL n/a n/a
101 4BMB Ka = 13000 M^-1 BGC GAL n/a n/a
102 5T7I Kd = 0.33 uM BGC GAL NAG GAL n/a n/a
103 3VKO - NAG GAL SIA n/a n/a
104 4BME Ka = 13000 M^-1 GLC GAL n/a n/a
105 6W4Z Kd = 9.17 uM SZS C17 H22 O9 CO[C@H]1[C....
106 5T7T Kd = 2.1 uM NAG GAL n/a n/a
107 6N3R - GAL C6 H12 O6 C([C@@H]1[....
108 3I8T Kd = 600 uM GLC GAL n/a n/a
109 3WV6 - BGC GAL n/a n/a
110 3NV2 - NDG GAL n/a n/a
111 3NV4 - BGC GAL SIA n/a n/a
112 3NV3 - MAN NAG GAL n/a n/a
113 6LJQ - BGC GAL n/a n/a
114 3WUD Kd = 41 uM GLC GAL n/a n/a
115 3GAL - 1GN C6 H13 N O5 C([C@@H]1[....
116 4UW6 - VV7 C69 H77 N20 O39 c1c(cc(cc1....
117 2GAL - GAL C6 H12 O6 C([C@@H]1[....
118 4GAL - BGC GAL n/a n/a
119 4UW3 - 50G C31 H50 N10 O18 c1c(nnn1[C....
120 4UW4 - 4S0 C49 H80 N10 O33 c1c(nnn1[C....
121 3ZXE Kd = 450 uM PGZ C22 H28 N O8 P S Cc1ccc(cc1....
122 5GAL - NAG GAL n/a n/a
123 4UW5 - 4S0 C49 H80 N10 O33 c1c(nnn1[C....
124 1A78 - YIO GAL n/a n/a
125 5DUW Kd = 510 uM BGC SGA n/a n/a
126 5DUV Kd = 1300 uM BGC GAL n/a n/a
127 5DUX Kd = 380 uM BGC GAL FUC n/a n/a
128 4WVV - GLC GAL n/a n/a
129 4WVW - GLC GAL SIA n/a n/a
130 4YLZ Kd = 270 uM BGC GAL NAG GAL n/a n/a
131 5CBL - BGC GAL n/a n/a
132 4YM0 Kd = 510 uM BGC GAL NAG GAL n/a n/a
133 4YM2 Kd = 1400 uM BGC GAL n/a n/a
134 4YM3 Kd = 1900 uM BGC GAL n/a n/a
135 4YM1 Kd = 580 uM BGC GAL FUC n/a n/a
136 1IS4 - BGC GAL n/a n/a
137 1WLD - BGC GAL n/a n/a
138 6FOF - BGC GAL n/a n/a
139 5NFB Kd = 0.77 uM 8VT C30 H40 N2 O13 CC(=O)N[C@....
140 5NF7 Kd = 37.5 uM TVD GAL n/a n/a
141 1SLA - NAG BMA MAN MAN NAG GAL NAG GAL n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: GLC GAL; Similar ligands found: 0
No: Ligand ECFP6 Tc MDL keys Tc
Similar Ligands (3D)
Ligand no: 1; Ligand: GLC GAL; Similar ligands found: 153
No: Ligand Similarity coefficient
1 GLC GAL 1.0000
2 BGC GAL 0.9939
3 GLC BGC 0.9708
4 MGL GAL 0.9644
5 PA1 GCS 0.9638
6 BMA GAL 0.9621
7 BGC BGC 0.9620
8 BGC Z9D 0.9601
9 ABL 0.9534
10 SHG BGC 0.9495
11 FRU GAL 0.9492
12 NOY BGC 0.9473
13 GLC GLC 0.9449
14 GCS GCS 0.9448
15 BGC OXZ 0.9401
16 GCU BGC 0.9395
17 9MR 0.9371
18 IFM BGC 0.9339
19 SGC BGC 0.9325
20 MGL SGC 0.9323
21 GAL NOK 0.9310
22 NOK GAL 0.9310
23 GAL NGT 0.9309
24 NGT GAL 0.9309
25 BMA BGC 0.9303
26 YIO GAL 0.9301
27 145 0.9284
28 NDG GAL 0.9259
29 FUC GAL 0.9248
30 NAG GAL 0.9240
31 GAL GC2 0.9214
32 MAN BMA 0.9167
33 IDC 0.9114
34 GAL GAL 0.9109
35 BMA BMA 0.9105
36 LOG GAL 0.9094
37 ISX 0.9080
38 43S 0.9071
39 GAL GLA 0.9062
40 IFM BMA 0.9056
41 BGC GLC 0.9028
42 4WS GAL 0.9010
43 MHD GAL 0.9006
44 JRO 0.8990
45 MAV BEM 0.8980
46 BEM LGU 0.8965
47 A2G GAL 0.8955
48 MBG GAL 0.8920
49 NGA GAL 0.8910
50 MA1 GLC 0.8908
51 LAM 0.8904
52 64I 0.8886
53 NAG GCD 0.8880
54 NAG GAD 0.8880
55 6GR 0.8879
56 IXM 0.8874
57 NAG GC4 0.8870
58 GAL FUC 0.8851
59 ZT2 0.8848
60 GRI 0.8844
61 BQZ 0.8840
62 636 0.8840
63 BEM BEM 0.8834
64 CZ0 0.8829
65 LG7 0.8823
66 683 0.8822
67 DTK 0.8806
68 GWD 0.8804
69 9CE 0.8804
70 TXQ 0.8803
71 BGC SGA 0.8792
72 MYG 0.8786
73 SGC GLC 0.8781
74 19E 0.8774
75 6EN 0.8773
76 EZB 0.8771
77 MNY 0.8764
78 MGC GAL 0.8761
79 7D0 0.8752
80 DSQ 0.8745
81 GCO GAL 0.8744
82 NXB 0.8741
83 BNY 0.8738
84 HFZ 0.8738
85 CC6 0.8737
86 38E 0.8728
87 HO4 0.8727
88 XYS XYP 0.8724
89 HDU 0.8722
90 NDG GAD 0.8710
91 9RM 0.8706
92 MMA XYP 0.8705
93 JMS 0.8705
94 2HN 0.8704
95 581 0.8703
96 XYP XYP 0.8698
97 K3Q 7CV 0.8695
98 JY4 0.8693
99 TGW 0.8693
100 MNX 0.8689
101 NOM 0.8689
102 GLO BGC 0.8686
103 LM7 0.8683
104 AFX 0.8680
105 GAL NPO 0.8676
106 147 0.8676
107 8SK 0.8669
108 DS8 0.8667
109 5I5 0.8667
110 E3Y 0.8667
111 43U 0.8667
112 E44 0.8663
113 553 0.8661
114 CB1 0.8654
115 XYP XIM 0.8651
116 MVL BMA 0.8651
117 56N 0.8651
118 DNQ 0.8650
119 CJZ 0.8648
120 LUM 0.8646
121 HNA 0.8645
122 17C 0.8645
123 EUN 0.8642
124 U19 0.8638
125 LFN 0.8636
126 1YE 0.8634
127 DY9 0.8632
128 XYS XYS 0.8625
129 GMP 0.8625
130 113 0.8625
131 47N 0.8619
132 MQS 0.8605
133 GAT 0.8604
134 B2X 0.8603
135 041 0.8596
136 TLF 0.8594
137 MTA 0.8590
138 6J3 0.8588
139 ID8 0.8585
140 RPP 0.8584
141 XIF XYP 0.8579
142 XYP XYS 0.8575
143 XDL XYP 0.8574
144 1FL 0.8564
145 BZC 0.8559
146 B2L 0.8554
147 LOX XYP 0.8551
148 WS6 0.8541
149 8WB 0.8538
150 FHI 0.8535
151 GN6 0.8535
152 ZJB 0.8531
153 ADN 0.8528
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3WUD; Ligand: GLC GAL; Similar sites found with APoc: 2
This union binding pocket(no: 1) in the query (biounit: 3wud.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
1 3VV1 FUC GAL 36.0294
2 3VV1 FUC GAL 36.0294
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