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Receptor
PDB id Resolution Class Description Source Keywords
3UEC 2.18 Å NON-ENZYME: TOXIN_VIRAL CRYSTAL STRUCTURE OF HUMAN SURVIVIN BOUND TO HISTONE H3 PHOS ON THREONINE-3. HOMO SAPIENS ZINC FINGER PHOSPHORYLATED THREONINE CELL CYCLE BIR DOMAICHROMOSOMAL PASSENGER COMPLEX CELL DIVISION MITOSIS
Ref.: MOLECULAR BASIS FOR PHOSPHOSPECIFIC RECOGNITION OF H3 TAILS BY SURVIVIN PARALOGUES AT INNER CENTROMERE MOL.BIOL.CELL V. 23 1457 2012
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
1PE A:146;
Invalid;
none;
submit data
238.278 C10 H22 O6 C(COC...
ACT A:148;
Invalid;
none;
submit data
59.044 C2 H3 O2 CC(=O...
ALA ARG TPO LYS B:1;
Valid;
none;
Kd = 60.6 uM n/a n/a n/a n/a
EDO A:144;
A:147;
Invalid;
Invalid;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
PEG A:149;
Invalid;
none;
submit data
106.12 C4 H10 O3 C(COC...
PG4 A:145;
Invalid;
none;
submit data
194.226 C8 H18 O5 C(COC...
ZN A:143;
Part of Protein;
none;
submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3UEC 2.18 Å NON-ENZYME: TOXIN_VIRAL CRYSTAL STRUCTURE OF HUMAN SURVIVIN BOUND TO HISTONE H3 PHOS ON THREONINE-3. HOMO SAPIENS ZINC FINGER PHOSPHORYLATED THREONINE CELL CYCLE BIR DOMAICHROMOSOMAL PASSENGER COMPLEX CELL DIVISION MITOSIS
Ref.: MOLECULAR BASIS FOR PHOSPHOSPECIFIC RECOGNITION OF H3 TAILS BY SURVIVIN PARALOGUES AT INNER CENTROMERE MOL.BIOL.CELL V. 23 1457 2012
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 62 families.
1 3UEC Kd = 60.6 uM ALA ARG TPO LYS n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 43 families.
1 3UEC Kd = 60.6 uM ALA ARG TPO LYS n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 35 families.
1 3UEC Kd = 60.6 uM ALA ARG TPO LYS n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ALA ARG TPO LYS; Similar ligands found: 0
No: Ligand ECFP6 Tc MDL keys Tc
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3UEC; Ligand: ALA ARG TPO LYS; Similar sites found with APoc: 295
This union binding pocket(no: 1) in the query (biounit: 3uec.bio1) has 11 residues
No: Leader PDB Ligand Sequence Similarity
1 1KQB FMN None
2 1ICV FMN None
3 4FJU NAI None
4 4FJU GLV None
5 1QSM ACO None
6 4DS0 A2G GAL NAG FUC None
7 1JYQ MAZ PTR PTM ASN None
8 2QTR NXX None
9 1L6O SER LEU LYS LEU MET THR THR VAL None
10 6FX2 FUC C4W NAG BMA MAN NAG GAL None
11 2UZH CDP None
12 1KQB BEZ None
13 1S17 GNR None
14 6FIV 3TL None
15 1NE7 16G 1.36986
16 1G79 FMN 1.36986
17 1G79 PLP 1.36986
18 2FXU BID 1.36986
19 3R5Z F42 1.37931
20 3WYJ H78 2.05479
21 2VNI FAD 2.05479
22 2VNI A2P 2.05479
23 2PHN GDP 2.05479
24 2QTZ FAD 2.05479
25 4UTW RFW 2.05479
26 4F07 FAD 2.73973
27 4YRY FAD 2.73973
28 4YRY NAD 2.73973
29 3ZJ0 ACO 2.73973
30 1J0D 5PA 2.73973
31 3GD8 GOL 2.73973
32 4G0P U5P 2.73973
33 2FT0 ACO 2.73973
34 5NQR 958 2.73973
35 6GEH FAD 2.73973
36 4ONC 40B 2.73973
37 3R5Y F42 2.73973
38 3WR7 COA 2.73973
39 4KQR VPP 2.73973
40 6DA9 FMN 2.73973
41 4QLX KTC 3.42466
42 3HY8 PLP 3.42466
43 3HY8 FMN 3.42466
44 4DDY DN6 3.42466
45 4DE2 DN3 3.42466
46 4DDS 0J7 3.42466
47 6BU3 3GK 3.42466
48 4UA7 3GK 3.42466
49 4UAA 3GK 3.42466
50 4QLX FMN 3.42466
51 6BT6 3GK 3.42466
52 4R57 ACO 3.42466
53 1LCK GLU GLY GLN PTR GLN PRO GLN PRO ALA 3.42466
54 5UBG PRT 3.42466
55 3G2Y GF4 3.42466
56 4B74 1LH 3.42466
57 2BTO GTP 3.42466
58 4MAF ADX 3.42466
59 4U03 TLL 3.42466
60 4U03 GTP 3.42466
61 4D57 ARG AMP 3.42466
62 1RJW ETF 3.42466
63 4YBN FAD 3.42466
64 4DE1 0J6 3.42466
65 3HUN ZZ7 3.42466
66 4DE3 DN8 3.42466
67 6C6O ENG 3.42466
68 4DE0 0JB 3.42466
69 6ACS CIT 3.42466
70 2CWH PYC 3.42466
71 2CWH NDP 3.42466
72 3BNK FMN 3.42466
73 4BXK 1IU 3.42466
74 1F20 FAD 3.42466
75 5FAL SKT 3.42466
76 5FAL COA 3.42466
77 1ZCH FMN 3.42466
78 2Y91 98J 3.42466
79 5IE3 OXD 3.42466
80 5IE3 AMP 3.42466
81 4CS4 ANP 3.42466
82 3QH2 3NM 3.42466
83 4EZW ASN ARG LEU LEU LEU THR GLY 3.42466
84 4WQM FAD 3.42466
85 4EO3 FMN 3.42466
86 3UG4 AHR 3.42466
87 4G6I RS3 3.42466
88 4G1V FAD 3.42466
89 4P5E N6P 3.94737
90 5SWB NAG BMA MAN MAN MAN MAN 4.10959
91 4QVB F42 4.10959
92 3DLG GWE 4.10959
93 2J07 FAD 4.10959
94 2J07 HDF 4.10959
95 5AE2 FYC 4.10959
96 5AE2 FAD 4.10959
97 5YLY FAD 4.10959
98 4OYA 1VE 4.10959
99 1PI5 SM2 4.10959
100 2ZBA COA 4.10959
101 6BA2 7KM 4.10959
102 1DNP FAD 4.10959
103 2EIX FAD 4.10959
104 3OJF NDP 4.10959
105 4NBI D3Y 4.10959
106 2OJW ADP 4.10959
107 1E7S NAP 4.10959
108 2CNE DFJ 4.10959
109 5VKM GAL SIA 4.10959
110 2Y4O DLL 4.10959
111 5UJ3 CE4 4.13793
112 3EM0 CHD 4.34783
113 2D37 FMN 4.54545
114 2D37 NAD 4.54545
115 6DWD GTP 4.79452
116 6DWD HDV 4.79452
117 2II3 CAO 4.79452
118 5JCA FAD 4.79452
119 4ZEI LAO 4.79452
120 3OZV ECN 4.79452
121 5JBE GLC GLC GLC GLC GLC 4.79452
122 3HXU A5A 4.79452
123 3OZV FAD 4.79452
124 1QX4 FAD 4.79452
125 4HVA 4HV 4.79452
126 4U9U FAD 4.79452
127 2VZZ SCA 4.79452
128 1PVS 7HP 4.79452
129 4YSX FAD 4.79452
130 5N81 8Q2 4.79452
131 1KRH FAD 4.79452
132 2ED4 FAD 4.79452
133 3E9I XAH 4.79452
134 2XQ0 BES 4.79452
135 3UWV 2PG 4.79452
136 4ZH7 FUC GAL NAG GAL FUC 4.79452
137 1QNF FAD 4.79452
138 1VBJ NAP 4.79452
139 1F5V FMN 5
140 2AZC 3TL 5.05051
141 2P3C 3TL 5.05051
142 3ZOD FMN 5.47945
143 3ZOD HQE 5.47945
144 5F1R 42O 5.47945
145 4P86 5GP 5.47945
146 3N2S FMN 5.47945
147 4PO2 ASN ARG LEU LEU LEU THR GLY 5.47945
148 2MBR FAD 5.47945
149 2MBR EPU 5.47945
150 3S6X SIA GAL BGC 5.47945
151 4DV8 0LX 5.47945
152 4ONT SIA GAL BGC 5.47945
153 5M90 JIF 5.47945
154 1V25 ANP 5.47945
155 5H5J FAD 5.47945
156 5O0X FAD 5.47945
157 4TQK NAG 5.47945
158 1JIL 485 5.47945
159 2P3B 3TL 6.06061
160 6C8X BVR 6.06061
161 3M6P BB2 6.16438
162 4PYW ACE THR THR ALA ILE NH2 6.16438
163 2PID YSA 6.16438
164 1P7T ACO 6.16438
165 4UP4 NDG 6.16438
166 5OE4 3UK 6.16438
167 3QT6 2P0 6.16438
168 3R6K FUC GAL GLA 6.84932
169 5D9J 0N8 6.84932
170 3W2E NAD 6.84932
171 3W2E FAD 6.84932
172 2IVF MGD 6.84932
173 1F0X FAD 6.84932
174 5HDJ FMN 6.84932
175 1YOA FAD 6.84932
176 1VA6 ADP 6.84932
177 2EW5 Y12 7.53425
178 3PE2 E1B 7.53425
179 4KOT CE3 7.53425
180 2V58 LZJ 7.53425
181 1EP2 FAD 7.53425
182 4WHZ 3NL 7.53425
183 4ZTE 4RL 7.53425
184 2ZXG S23 7.53425
185 1HSK FAD 7.53425
186 2XNJ NAP 7.53425
187 2XNJ FAD 7.53425
188 4EOX 0S5 7.53425
189 1QKQ MAN 7.74648
190 3A5Y KAA 8.21918
191 4GAA BES 8.21918
192 3A5Z KAA 8.21918
193 2PIA FMN 8.21918
194 3O9L LPN 8.21918
195 5MRH Q9Z 8.21918
196 1T3Q FAD 8.21918
197 1KUV CA5 8.21918
198 1A8P FAD 8.21918
199 2H29 DND 8.21918
200 2CND FAD 8.21918
201 4B4D FAD 8.21918
202 1O44 852 8.33333
203 1PZO CBT 8.36502
204 4XIZ LPP 8.57143
205 5HI5 63Q 8.90411
206 4JB1 FAD 8.90411
207 4JB1 NAP 8.90411
208 1E8G FAD 8.90411
209 1E8G FCR 8.90411
210 2UUU PL3 8.90411
211 2UUU FAD 8.90411
212 4P8K 38C 8.90411
213 4P8K FAD 8.90411
214 3AB4 LYS 8.90411
215 3OZ2 FAD 8.90411
216 5HC8 61G 8.90411
217 5HC8 PIS 8.90411
218 5HC8 ISY 8.90411
219 1EXB NDP 8.90411
220 2GOU FMN 8.90411
221 4GU5 FAD 8.90411
222 4MN3 ACE PHE ALA TYR M3L SER NH2 8.92857
223 1I0S FMN 9.58904
224 1I0S NAP 9.58904
225 3TAY MN0 9.58904
226 2BSA NAP 9.58904
227 2BSA FAD 9.58904
228 1U1F 183 9.58904
229 3JQQ A2P 9.58904
230 3JQQ FAD 9.58904
231 1EWY FAD 9.58904
232 4AUT FAD 9.58904
233 4JTA NAP 9.58904
234 1FIQ FAD 9.58904
235 2BTM PGA 9.58904
236 1AMU AMP 9.58904
237 1JOC ITP 9.6
238 1SM4 FAD 10.1351
239 3QX9 ATP 10.1449
240 3K87 FAD 10.274
241 1NLU IVA PHI TYB 10.274
242 5OGX FAD 10.274
243 1GAW FAD 10.274
244 3MHP FAD 10.274
245 1QFY FAD 10.274
246 1QFY NAP 10.274
247 1RM6 FAD 10.274
248 3HRD FAD 10.274
249 2NLI LAC 10.274
250 2NLI FMN 10.274
251 3IAL PR8 10.274
252 3HRD NIO 10.274
253 1V5Y 4HC 11.6438
254 1V5Y FMN 11.6438
255 4FOU C2E 11.6438
256 3VO1 FAD 11.6438
257 1EYN 2AN 11.6438
258 1BKJ FMN 11.6438
259 4G17 0VN 11.6438
260 3RYC GTP 11.8881
261 1FND FAD 12.3288
262 1FND A2P 12.3288
263 4HI0 GDP 12.3288
264 5WA0 MSS 12.3288
265 4X3H ARG ILE PRO SER TYR ARG TYR ARG TYR 12.6582
266 2RKV COA 13.0137
267 2RKV ZBA 13.0137
268 4Z3X 4KX 13.0137
269 4Z3X MTE 13.0137
270 5LYH 7B8 13.0137
271 3SWG EPZ 13.0137
272 3VCY UD1 14.3836
273 5MY8 RXZ 14.3836
274 4YHB FAD 15.0685
275 2RL1 UD1 16.4384
276 1TLL FAD 16.4384
277 2YNC YNC 16.4384
278 1USF FMN 17.1233
279 1USF NAP 17.1233
280 2RFZ CTR 17.8082
281 2RG0 CBI 17.8082
282 2VNF ALA ARG THR M3L GLN THR ALA ARG LYS SER 18.3333
283 4LOO SB4 18.4932
284 1H3F TYE 18.4932
285 5V59 8X1 21.2329
286 1YQS BSA 21.9178
287 2WBV SIA 21.9178
288 5ZA2 NXL 23.2877
289 4MTI 2DX 27.8261
290 3CM2 X23 33.0769
291 5OQW A4E 33.8583
292 1X7D ORN 37.6712
293 5C83 4YN 39.0909
294 2VSL MAA LYS PRO PHE 44.7917
295 4KJU 1RH 45.3488
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