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Receptor
PDB id Resolution Class Description Source Keywords
3TZM 1.7 Å EC: 2.7.11.30 TGF-BETA RECEPTOR TYPE 1 IN COMPLEX WITH SB431542 HOMO SAPIENS ALK5 SB431542 KINASE DOMAIN TRANSFERASE-TRANSFERASE INHIBCOMPLEX
Ref.: STRUCTURAL BASIS FOR SPECIFICITY OF TGFBETA FAMILY SMALL MOLECULE INHIBITORS CELL SIGNAL V. 24 476 2012
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
085 A:1;
Valid;
none;
submit data
384.387 C22 H16 N4 O3 c1ccn...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1VJY 2 Å EC: 2.7.11.30 CRYSTAL STRUCTURE OF A NAPHTHYRIDINE INHIBITOR OF HUMAN TGF- BETA TYPE I RECEPTOR HOMO SAPIENS TRANSFERASE PROTEIN KINASE INHIBITOR COMPLEX
Ref.: IDENTIFICATION OF 1,5-NAPHTHYRIDINE DERIVATIVES AS A NOVEL SERIES OF POTENT AND SELECTIVE TGF-BETA TYPE I RECEPTOR INHIBITORS. J.MED.CHEM. V. 47 4494 2004
Members (17)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 4X2F - 3WJ C13 H11 N5 O c1cc(ccc1N....
2 4X0M - 3WA C7 H6 N4 O c1nc(c2c(n....
3 1RW8 ic50 = 0.175 uM 580 C18 H16 F N3 Cc1cccc(n1....
4 3GXL ic50 = 0.025 uM QIG C21 H16 N6 Cc1cccc(n1....
5 5QIM - J2Y C20 H17 N5 O2 CC(=O)Nc1c....
6 2WOT ic50 = 44 nM ZZG C26 H26 N4 O4 Cc1cc(c(nc....
7 1VJY Ki = 0.023 uM 460 C17 H15 N5 Cc1cccc(n1....
8 4X2K - 3WO C13 H11 N5 O c1cc(cc(c1....
9 4X2G - 3WK C13 H11 N5 O c1cc(ccc1N....
10 5QIK - J2M C19 H16 F N5 O2 CC(=O)Nc1c....
11 5QIL - J2V C20 H17 N5 O2 CC(=O)Nc1c....
12 4X2J - 3WN C13 H11 N5 O c1cc(cc(c1....
13 2WOU ic50 = 72 nM ZZF C18 H18 N4 O3 S Cc1ccc(c(n....
14 3HMM ic50 = 0.025 uM 855 C19 H15 N5 Cc1cccc(n1....
15 3TZM - 085 C22 H16 N4 O3 c1ccnc(c1)....
16 1PY5 ic50 = 51 nM PY1 C17 H12 N4 c1ccc2c(c1....
17 6B8Y - D0A C17 H10 F4 N6 c1cc(nc(c1....
70% Homology Family (20)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 4X2F - 3WJ C13 H11 N5 O c1cc(ccc1N....
2 4X0M - 3WA C7 H6 N4 O c1nc(c2c(n....
3 1RW8 ic50 = 0.175 uM 580 C18 H16 F N3 Cc1cccc(n1....
4 3GXL ic50 = 0.025 uM QIG C21 H16 N6 Cc1cccc(n1....
5 5QIM - J2Y C20 H17 N5 O2 CC(=O)Nc1c....
6 2WOT ic50 = 44 nM ZZG C26 H26 N4 O4 Cc1cc(c(nc....
7 1VJY Ki = 0.023 uM 460 C17 H15 N5 Cc1cccc(n1....
8 4X2K - 3WO C13 H11 N5 O c1cc(cc(c1....
9 4X2G - 3WK C13 H11 N5 O c1cc(ccc1N....
10 5QIK - J2M C19 H16 F N5 O2 CC(=O)Nc1c....
11 5QIL - J2V C20 H17 N5 O2 CC(=O)Nc1c....
12 4X2J - 3WN C13 H11 N5 O c1cc(cc(c1....
13 2WOU ic50 = 72 nM ZZF C18 H18 N4 O3 S Cc1ccc(c(n....
14 3HMM ic50 = 0.025 uM 855 C19 H15 N5 Cc1cccc(n1....
15 3TZM - 085 C22 H16 N4 O3 c1ccnc(c1)....
16 1PY5 ic50 = 51 nM PY1 C17 H12 N4 c1ccc2c(c1....
17 6B8Y - D0A C17 H10 F4 N6 c1cc(nc(c1....
18 6GI6 Kd = 0.194 uM EZB C18 H13 N3 O Cc1c(ccc2c....
19 6GIP ic50 = 0.042 uM EUN C19 H15 N3 O Cc1c(ccc2c....
20 6GIN ic50 = 0.032 uM IR2 C27 H22 N4 O2 c1ccc2c(c1....
50% Homology Family (22)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 4X2F - 3WJ C13 H11 N5 O c1cc(ccc1N....
2 4X0M - 3WA C7 H6 N4 O c1nc(c2c(n....
3 1RW8 ic50 = 0.175 uM 580 C18 H16 F N3 Cc1cccc(n1....
4 3GXL ic50 = 0.025 uM QIG C21 H16 N6 Cc1cccc(n1....
5 5QIM - J2Y C20 H17 N5 O2 CC(=O)Nc1c....
6 2WOT ic50 = 44 nM ZZG C26 H26 N4 O4 Cc1cc(c(nc....
7 1VJY Ki = 0.023 uM 460 C17 H15 N5 Cc1cccc(n1....
8 4X2K - 3WO C13 H11 N5 O c1cc(cc(c1....
9 4X2G - 3WK C13 H11 N5 O c1cc(ccc1N....
10 5QIK - J2M C19 H16 F N5 O2 CC(=O)Nc1c....
11 5QIL - J2V C20 H17 N5 O2 CC(=O)Nc1c....
12 4X2J - 3WN C13 H11 N5 O c1cc(cc(c1....
13 2WOU ic50 = 72 nM ZZF C18 H18 N4 O3 S Cc1ccc(c(n....
14 3HMM ic50 = 0.025 uM 855 C19 H15 N5 Cc1cccc(n1....
15 3TZM - 085 C22 H16 N4 O3 c1ccnc(c1)....
16 1PY5 ic50 = 51 nM PY1 C17 H12 N4 c1ccc2c(c1....
17 6B8Y - D0A C17 H10 F4 N6 c1cc(nc(c1....
18 6GI6 Kd = 0.194 uM EZB C18 H13 N3 O Cc1c(ccc2c....
19 6GIP ic50 = 0.042 uM EUN C19 H15 N3 O Cc1c(ccc2c....
20 6GIN ic50 = 0.032 uM IR2 C27 H22 N4 O2 c1ccc2c(c1....
21 2QLU - ADE C5 H5 N5 c1[nH]c2c(....
22 5QIN - J2V C20 H17 N5 O2 CC(=O)Nc1c....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 085; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 085 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1VJY; Ligand: 460; Similar sites found with APoc: 681
This union binding pocket(no: 1) in the query (biounit: 1vjy.bio1) has 33 residues
No: Leader PDB Ligand Sequence Similarity
1 3SAO DBH None
2 4MUV PCG None
3 1FUT 2GP None
4 5NLD LBT None
5 2Z6C FMN None
6 1ZNY GDP 0.966184
7 3ORQ ADP 0.990099
8 1JCM 137 1.1583
9 1I7L ATP 1.32013
10 2V58 LZJ 1.32013
11 1M0W ANP 1.32013
12 3ACL 3F1 1.35135
13 1H65 GDP 1.48148
14 3LE7 ADE 1.53257
15 2Z3U CRR 1.65016
16 3JQ3 ADP 1.65016
17 2OS2 OGA 1.65016
18 2Q8E OGA 1.65016
19 2YBP 2HG 1.65016
20 4CC6 L5Y 1.65016
21 2P5B OGA 1.65016
22 5WS9 OXL 1.65016
23 3ETH ATP 1.65016
24 5WS9 ATP 1.65016
25 1QY1 PRZ 1.72414
26 2AQX ATP 1.7301
27 3GD8 GOL 1.79372
28 6GG9 FMN 1.85185
29 5CPR 539 1.86567
30 2PNC CLU 1.9802
31 3TY5 ATP 1.9802
32 1CKM GTP 1.9802
33 3QSB 743 1.9802
34 1YKD CMP 1.9802
35 1CKN GTP 1.9802
36 2H7C SIA 1.9802
37 2W92 NGT 1.9802
38 1EHI ADP 1.9802
39 3SCH TB6 2.0202
40 2QHS OCA 2.1097
41 6CC0 EWM 2.1097
42 5DEQ ARA 2.19298
43 5XLY C2E 2.25564
44 4ZDM GLY 2.29885
45 2Z6D FMN 2.30769
46 5ZCT ANP 2.31023
47 3AKK ADP 2.31023
48 4OCJ NDG 2.31023
49 5C1P ADP 2.31023
50 1ELI PYC 2.31023
51 5OLK DTP 2.31023
52 3S6X SIA GAL BGC 2.31023
53 2YW2 ATP 2.31023
54 4FE2 ADP 2.35294
55 4FE2 AIR 2.35294
56 2VDF OCT 2.37154
57 2QHV OC9 2.38095
58 4N9I PCG 2.38095
59 5L9V OGA 2.38095
60 3FIU AMP 2.40964
61 2WKQ FMN 2.40964
62 4B1L FRU 2.42424
63 5OCQ CIT 2.45614
64 5GLT BGC GAL NAG GAL 2.46479
65 2Z9I GLY ALA THR VAL 2.46914
66 2YY8 MTA 2.48756
67 4C5N ACP 2.53623
68 3Q60 ATP 2.64026
69 5YJS SAL 2.64026
70 4OCV ANP 2.64026
71 3OPT AKG 2.64026
72 3UN3 G16 2.64026
73 4PAB THG 2.64026
74 2GVJ DGB 2.64026
75 4ZH7 FUC GAL NAG GAL FUC 2.64026
76 1V8B ADN 2.64026
77 1ULE GLA GAL NAG 2.66667
78 1WEI ADE 2.66667
79 4RT1 C2E 2.67857
80 2V0U FMN 2.73973
81 4O4F ATP 2.82258
82 4O4F IHP 2.82258
83 3A76 SPD 2.84091
84 4YRI 4JH 2.85088
85 6FA4 D1W 2.89017
86 5TV6 PML 2.91667
87 5H9I XAN 2.91667
88 3RK1 ATP 2.95359
89 5KJW 53C 2.9703
90 1GSA ADP 2.9703
91 2VPQ ANP 2.9703
92 5I35 ANP 2.9703
93 5DZT AMP 2.9703
94 1GPM AMP 2.9703
95 1K0E TRP 2.9703
96 5XLS URA 2.98851
97 5MOB A8S 3.01724
98 1P0Z FLC 3.05344
99 5HWV MBN 3.07692
100 3P7N FMN 3.10078
101 2CDO GAL AAL GAL AAL GAL AAL 3.125
102 3T50 FMN 3.125
103 2QX0 PH2 3.14465
104 3EXS 5RP 3.16742
105 5OCG 9R5 3.1746
106 1NE6 SP1 3.18021
107 2RDE C2E 3.18725
108 5A96 GTP 3.21285
109 3PDT ADP 3.27273
110 1SDW IYT 3.30033
111 5MW8 ATP 3.30033
112 3CBC DBS 3.30033
113 4LIT AKG 3.30033
114 4UWH JXM 3.30033
115 2IO8 ADP 3.30033
116 5KY9 GDP 3.30033
117 4L77 CNL 3.30033
118 6C1S EFV 3.30033
119 1OFL NGK GCD 3.30033
120 3BEO UDP 3.30033
121 4WOE ADP 3.30033
122 4A1O JLN 3.30033
123 4QDC ASD 3.30033
124 4RW3 IPD 3.31126
125 1GZF NIR 3.31754
126 3T4L ZEA 3.33333
127 5OF1 SAL 3.33333
128 1GU3 BGC BGC BGC BGC BGC 3.3557
129 1NBU PH2 3.36134
130 1F5F DHT 3.41463
131 1UWC FER 3.44828
132 3VKX T3 3.44828
133 4EES FMN 3.47826
134 2ET1 GLV 3.48259
135 3OQJ 3CX 3.50195
136 2PYY GLU 3.50877
137 3VPC ADP 3.5461
138 3VPB ADP 3.5461
139 3QPB URA 3.5461
140 5G48 1FL 3.63036
141 3DNT ATP 3.63036
142 3HQP OXL 3.63036
143 3TTM PUT 3.63036
144 3K5I ADP 3.63036
145 5UY8 AMZ 3.63036
146 3ZGJ RMN 3.63036
147 1I1Q TRP 3.64583
148 1N9L FMN 3.66972
149 4LO6 SIA GAL 3.68421
150 2YKL NLD 3.7037
151 6DZN AE3 3.75587
152 3KIF GDL 3.77358
153 1TQP ATP 3.90071
154 6CDO ALA VAL GLY ILE GLY ALA VAL PHE 3.91304
155 1F9V ADP 3.9604
156 4CYI ATP 3.9604
157 3ZJX BOG 3.9604
158 4MOB ADP 3.9604
159 4NOS ITU 3.9604
160 6EZ6 C5Z 3.9604
161 5AE9 OKO 3.9604
162 1CT9 AMP 3.9604
163 4IAW LIZ 4.25532
164 5YK1 ANP 4.29043
165 3I0O ADP 4.29043
166 3JU6 ANP 4.29043
167 4AZW ATP 4.29043
168 2VQD AP2 4.29043
169 5T8U LPA 4.29043
170 1LSH PLD 4.29043
171 6HSP COA 4.29043
172 2GKS ADP 4.29043
173 3HAV ATP 4.34783
174 3WUC GLC GAL 4.37956
175 3AHW 2AM 4.38596
176 6GNO XDI 4.44444
177 5TKJ ALA VAL GLY ILE GLY ALA VAL PHE 4.52489
178 4Y24 TD2 4.54545
179 4RD0 GDP 4.62046
180 1VRP ADP 4.62046
181 4PU5 ANP 4.62046
182 1C1X HFA 4.62046
183 3FXU TSU 4.62046
184 1BW9 PPY 4.62046
185 3SUC ATP 4.62046
186 1J3R 6PG 4.73684
187 3THR C2F 4.77816
188 2GC0 PAN 4.78723
189 5Y4R C2E 4.82759
190 5EJL C2E 4.83871
191 3VOT ADP 4.9505
192 3VSS FRU 4.9505
193 3W0O HY0 4.9505
194 3W0O ADP 4.9505
195 5EXK 5AD 4.9505
196 3QH2 3NM 4.97738
197 2D6M LBT 5.03145
198 1ZTH ADP 5.03876
199 1ZP9 ATP 5.03876
200 2XG5 EC2 5.04587
201 2XG5 EC5 5.04587
202 2GQS ADP 5.06329
203 2GQS C2R 5.06329
204 2GQR ADP 5.06329
205 4JH6 FCN 5.07246
206 5W10 CMP 5.12821
207 3OYW TDG 5.22388
208 4ZSI 4R1 5.26316
209 1I1E DM2 5.28053
210 5VZ0 ADP 5.28053
211 4OAV ACP 5.28053
212 3B6R ADP 5.28053
213 1MJT ITU 5.28053
214 3W5N RAM 5.28053
215 2IS6 ADP 5.28053
216 1W2D ADP 5.28302
217 1W2D 4IP 5.28302
218 3VPD ANP 5.33808
219 6CZI 38E 5.35714
220 1IA9 ANP 5.35714
221 3BXD INS 5.53633
222 2AGC DAO 5.55556
223 5EHS 5OY 5.59701
224 5EHS 2JJ 5.59701
225 4OUC 5ID 5.61056
226 6AC9 ANP 5.61056
227 3UDZ ADP 5.61056
228 6G34 5ID 5.61056
229 4RDL FUC GAL NDG FUC 5.61056
230 1S5O 152 5.61056
231 6FL8 TIY 5.61056
232 6FL8 ADP 5.61056
233 5TDF ADP 5.61056
234 2G50 PYR 5.61056
235 1NJJ GET 5.61056
236 5KBF CMP 5.64784
237 3M2W L8I 5.68562
238 3TM0 B31 5.70342
239 3TM0 ANP 5.70342
240 4R38 RBF 5.71429
241 5F6U 5VK 5.73248
242 3BRN SRO 5.73248
243 3KPB SAM 5.7377
244 3NV3 GAL NAG MAN 5.7971
245 4RYV ZEA 5.80645
246 3RE4 TO1 5.81395
247 2WBV SIA 5.82011
248 4LI4 AMP 5.88235
249 2BOS GLA GAL 5.88235
250 2BOS GLA GAL GLC 5.88235
251 6EWZ APC 5.90717
252 4RF7 ARG 5.94059
253 5OES ADP 5.94059
254 3E7S AT2 5.94059
255 6CGD AKN 5.94059
256 6CGD GNP 5.94059
257 1RYD GLC 5.94059
258 5L2R MLA 5.94059
259 4CU1 71S 5.94059
260 1XNG ATP 5.97015
261 1VBO MAN MAN MAN 6.04027
262 3VX3 ADP 6.04839
263 1S9D AFB 6.09756
264 3OF1 CMP 6.09756
265 4OFG PCG 6.25
266 4BQS K2Q 6.25
267 5MY8 RXZ 6.27063
268 1AUX AGS 6.27063
269 4BG4 ADP 6.27063
270 1PK8 ATP 6.27063
271 3TDV GDP 6.27063
272 5IM3 DTP 6.27063
273 1RE0 AFB 6.33484
274 2W58 ADP 6.43564
275 4ZGP ADP 6.48464
276 1U6R ADP 6.60066
277 5FI4 5XV 6.60066
278 4DFU QUE 6.60066
279 5DXT 5H5 6.60066
280 2PUL ACP 6.60066
281 2Q7D ANP 6.60066
282 5C4L 4XR 6.60066
283 4UCF GLA 6.60066
284 4LUS TCE 6.60066
285 4RGA 3PV 6.60066
286 5C4L SIS 6.60066
287 1BKC INN 6.64062
288 6BMN PAP 6.77966
289 6GBV FMN 6.84932
290 1OGX EQU 6.87023
291 5NC9 8SZ 6.88259
292 3KYF 5GP 5GP 6.92641
293 3TII ANP 6.93069
294 5VLQ ANP 6.93069
295 4J25 OGA 6.9869
296 5DYO FLU 7.07547
297 5H9Q TD2 7.09677
298 6E8I PTR 7.10059
299 2EB5 OXL 7.11611
300 3QXV MTX 7.14286
301 4RDN 6MD 7.18563
302 3DGY 2GP 7.2165
303 2GTF P1R 7.22222
304 4K55 H6P 7.25806
305 2IF8 ADP 7.26073
306 5MRH Q9Z 7.26073
307 5COU ATP 7.26073
308 1PVC ILE SER GLU VAL 7.35294
309 4IEN GDP 7.36196
310 4O9S 2RY 7.44186
311 5K2M ADP 7.54717
312 2PTM CMP 7.57576
313 3TTZ 07N 7.57576
314 2PR5 FMN 7.57576
315 4XMF HSM 7.6087
316 5VNF VAL THR SER VAL VAL 7.64331
317 4P86 5GP 7.65027
318 5C8W PCG 7.69231
319 4LRJ ANP 7.69231
320 4S1D 41M 7.72727
321 4XYM A12 7.82609
322 1KGI T4A 7.87402
323 3OCP CMP 7.91367
324 2I6A 5I5 7.92079
325 3I8T LBT 7.92683
326 2ZMF CMP 7.93651
327 4CS9 AMP 7.93651
328 5SVV FMN 8.0292
329 1GT4 UNA 8.1761
330 5O1I 9GH 8.21918
331 5EQY 5RA 8.25082
332 5N1P 8GK 8.25243
333 5KEW 6SB 8.33333
334 1TZD ADP 8.36364
335 5ZZO FLC 8.45771
336 5D9G GLU ASN LEU TYR PHE GLN 8.53659
337 4U98 ACP 8.58086
338 4XZ3 ACP 8.58086
339 4LHD GLY 8.58086
340 1G51 AMP 8.58086
341 5VM6 9EG 8.75912
342 1Q6O LG6 8.7963
343 2VT3 ATP 8.83721
344 4WUJ FMN 8.84354
345 4GCZ FMN 8.91089
346 1BC5 ACE ASN TRP GLU THR PHE 8.92193
347 1I7M CG 8.95522
348 3NZ1 3NY 9.1954
349 5KR7 6X9 9.24092
350 2QK4 ATP 9.24092
351 5Z5I XYP 9.24092
352 5F7Y GLC GAL NAG GAL FUC A2G 9.24092
353 1GG6 APL 9.27835
354 1CBK ROI 9.375
355 5TBM 79A 9.40171
356 1RDS GPC 9.52381
357 5MST FUM 9.57096
358 5DKK FMN 9.65517
359 2UV4 AMP 9.86842
360 1Q8Y ADP 9.90099
361 3WVR AMP 9.90099
362 1Q8Y ADE 9.90099
363 1SU2 ATP 10.0629
364 5N0L ILE 10.0629
365 4Q5H ANP 10.3448
366 4JR7 GNP 10.5611
367 2PYW ADP 10.5611
368 4ZS4 ATP 10.5611
369 3TTN SPD 10.5611
370 1T36 ADP 10.5611
371 1T36 U 10.5611
372 3H0L ADP 10.6383
373 3WG3 A2G GAL NAG FUC 10.6742
374 4WW7 AMP 10.6952
375 4M26 AKG 10.7143
376 2PZI AXX 10.8911
377 4Y0X ADP 10.8911
378 4R78 AMP 11.2211
379 2G30 ALA ALA PHE 11.2403
380 5DJT FMN 11.4754
381 5EFW FMN 11.6667
382 5AIG VPR 12
383 2P7Q GG6 12.0301
384 4YSX E23 12.0567
385 1SQL GUN 13.0137
386 3FHR P4O 13.2013
387 3CY2 MB9 13.5314
388 4N70 2HX 13.5314
389 4GYI ADP 13.8614
390 3LQV ADE 13.913
391 3X01 AMP 13.9949
392 3HMO STU 14.0351
393 1RGE 2GP 14.5833
394 5N87 N66 15.016
395 1A99 PUT 15.1815
396 2TPI ILE VAL 15.5172
397 5VCV 1N1 15.8416
398 5LI1 ANP 16.1716
399 5LI9 ACP 16.1716
400 1LNM DTX 16.3043
401 4ARU TLA 16.5016
402 4DC2 ADE 16.5016
403 5EH0 5NW 16.6667
404 4PNI KQQ 16.8317
405 4D1J DGJ 16.8317
406 3KYG 5GP 5GP 17.1806
407 5LXT ACP 17.4825
408 4UX9 ANP 17.8218
409 3TTI KBI 18.1518
410 3E7O 35F 18.1518
411 4WHZ 3NL 18.1518
412 3PTG 932 18.1518
413 1MFI FHC 18.4211
414 4L9I 8PR 18.4524
415 6C0T EE4 19.4719
416 4IZY 1J2 19.7832
417 5OMY 9YE 20.2046
418 3KIV ACA 20.2532
419 6BXI ANP 20.462
420 5DMZ ADP 21.1221
421 4FL3 ANP 21.4521
422 5Y86 HRM 21.7822
423 4O1P ANP 22.1122
424 6BFN DL1 22.4422
425 5YF9 NIO 22.7139
426 3PE2 E1B 22.8487
427 5C03 AGS 23.1023
428 2Z7R STU 23.1023
429 5M06 ADP 24.2754
430 4WOV 3SM 24.2902
431 3E8N ATP 24.7525
432 3E8N VRA 24.7525
433 4XH0 ADP 24.7525
434 3SLS ANP 24.7525
435 5ZTN CUR 24.7525
436 3SLS 77D 24.7525
437 6FYV 3NG 25.0825
438 3V8S 0HD 25.0825
439 2PVN P63 25.2841
440 5X8I SQZ 25.4125
441 6G33 5ID 25.4125
442 2BKK ADP 26.0355
443 4IDT T28 26.0726
444 4FG8 ATP 26.0726
445 5EFQ ADP 26.4026
446 4A4X JUP 26.5233
447 4IJP 1EH 26.7327
448 3DLS ADP 26.7327
449 5T8O 76Z 26.7327
450 4NST ADP 27.0627
451 4NST AF3 27.0627
452 6A1G 9OL 27.0627
453 4IX4 ADP 27.1429
454 4I94 ANP 27.3333
455 4CRL C1I 27.3927
456 2ZV2 609 27.5168
457 2F2U M77 27.7228
458 4UAL 3FV 27.7228
459 3TXO 07U 28.3828
460 3KN5 ANP 28.3828
461 1Y57 MPZ 28.3828
462 4X7Q 3YR 28.3828
463 2CSN CKI 28.6195
464 2H8H H8H 28.7129
465 6GZD LCI 28.7129
466 4Y85 499 28.7129
467 5IH9 6BF 29.0429
468 4WB6 ATP 29.0429
469 5CKW ANP 29.0429
470 5HCY 60D 29.3729
471 2GU8 796 29.3729
472 3FHI ANP 29.3729
473 1RE8 BD2 29.3729
474 5GZ9 ANP 29.3729
475 2QCS ANP 29.3729
476 3IDB ANP 29.3729
477 4WB7 ATP 29.3729
478 4BFM ANP 29.3729
479 4NFN 2KC 29.703
480 4BTK DTQ 29.703
481 2VN9 GVD 29.9003
482 1O9U ADZ 30.033
483 3HZT J60 30.033
484 2XK9 XK9 30.033
485 4WNK 453 30.033
486 4G17 0VN 30.033
487 3G5D 1N1 30.0699
488 4KBA 1QM 30.363
489 5W4W 9WG 30.363
490 5OKT 9XK 30.363
491 4F9C 0SX 30.363
492 4AUA 4AU 30.363
493 2VZ6 FEF 30.363
494 2WEL K88 30.6931
495 3FC2 IBI 30.6931
496 6FYL 3NG 30.6931
497 5TA6 79D 30.6931
498 2V7O DRN 30.6931
499 4I6H 1C8 31.0231
500 4AU8 Z3R 31.0811
501 5KO1 6UY 31.0954
502 4G31 0WH 31.1037
503 5HQ0 LZ9 31.1258
504 6GU6 1QK 31.1258
505 3PP0 03Q 31.3531
506 5CEO 50D 31.3531
507 4YZC STU 31.3531
508 2JLD AG1 31.3531
509 2WU6 DKI 31.3531
510 5UKL SIX 31.3531
511 3F7Z 34O 31.3531
512 4NM5 ADP 31.3531
513 3ZRM ZRM 31.3531
514 5USZ SKE 31.4879
515 1UNH IXM 31.5068
516 3O0G 3O0 31.5068
517 5LVP ATP 31.5113
518 1CM8 ANP 31.6832
519 3VHE 42Q 31.7549
520 2YAB AMP 32.0132
521 4E93 GUI 32.0132
522 1XJD STU 32.0132
523 2R5T ANP 32.0132
524 5EKO N17 32.0132
525 2J7T 274 32.1192
526 5VC5 96M 32.1799
527 4E1Z 0MX 32.3024
528 5JZJ AN2 32.3232
529 3RWP ABQ 32.3432
530 3LXN MI1 32.3432
531 3UIM ANP 32.3432
532 3PVW QRX 32.3432
533 3GC0 AMP 32.3432
534 4EWH T77 32.3636
535 5DRB 5FJ 32.646
536 4OH4 ANP 32.6733
537 3MVH WFE 32.6733
538 1U5R ATP 32.6733
539 2JDR L20 32.6733
540 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 32.6733
541 4GJ3 0XP 32.7815
542 1PHK ATP 32.8859
543 4C2V YJA 32.9825
544 4CFU 2WC 33.0033
545 2B9H ADP 33.0033
546 3IGO ANP 33.0033
547 2B9F ADP 33.0033
548 2B9I ADP 33.0033
549 2B9J ADP 33.0033
550 6GUE FB8 33.1126
551 4BCQ TJF 33.2226
552 4BCM T7Z 33.2226
553 3C0G 3AM 33.3333
554 5DEY 59T 33.3333
555 2YAK OSV 33.3333
556 4EUU BX7 33.3333
557 3ALN ANP 33.3333
558 3KRL KRL 33.3333
559 4BCN T9N 33.3333
560 1JBU BEN 33.3333
561 5LPB ADP 33.4459
562 4H3Q ANP 33.6634
563 2BPM 529 33.6634
564 6CMJ F6J 33.6634
565 5DBX ANP 33.6634
566 4C2W ANP 33.6918
567 4NW6 2NS 33.9934
568 5LPZ ADP 33.9934
569 5EYK 5U5 34.058
570 4WNP 3RJ 34.1463
571 3GGF GVD 34.2193
572 2XMY CDK 34.2282
573 5AX9 4KT 34.3234
574 4H3P ANP 34.3234
575 5BVE 4VG 34.3234
576 4QMN DB8 34.3234
577 4Y8D 49J 34.3234
578 4U44 3D9 34.3234
579 5AWM ANP 34.3234
580 4YMJ 4EJ 34.3234
581 1ZY5 ANP 34.3234
582 5LMK 6ZK 34.3434
583 5A6N U7E 34.629
584 5JGA 6KC 34.6535
585 3LXK MI1 34.6535
586 3GNI ATP 34.6535
587 5Y80 IRE 34.6535
588 2WEI VGG 34.8432
589 1OUK 084 34.9835
590 4ONA UW1 34.9835
591 4QTB 38Z 34.9835
592 4LOO SB4 34.9835
593 2RIO ADP 34.9835
594 3ORK AGS 34.9835
595 3VRY B43 35.3135
596 5JFS 6K0 35.3135
597 6GWR FEW 35.3135
598 3SRV S19 35.7401
599 4AT3 LTI 35.786
600 3DAK ANP 35.8621
601 5G1X ADP 36.1404
602 5L8L ADP 36.1404
603 3AQV TAK 36.2319
604 4F4P 0SB 36.2637
605 5HVJ ANP 36.3036
606 5LXM ADP 36.3958
607 5ODT ADP 36.3958
608 3GC8 B45 36.6337
609 4OTH DRN 36.6337
610 6CQF F97 37.037
611 1EB1 ASP TYR GLU PRO ILE PRO GLU GLU ALA PHE 37.037
612 4RFM 3P6 37.594
613 5EW9 5VC 38.3764
614 3E5A VX6 38.4328
615 1V0O INR 38.5417
616 5UIU 8CG 39.0093
617 6ES0 BW8 39.2739
618 2OFV 242 39.3502
619 2A19 ANP 39.4366
620 4CLI 5P8 39.604
621 5DH3 5BS 39.604
622 2HK5 1BM 39.6296
623 2F57 23D 39.934
624 4BHN BH9 39.934
625 4ITH RCM 40.1361
626 6CZ3 FLJ 40.1515
627 5EOB 5QQ 40.264
628 5U6C 7YS 40.3175
629 3PLS ANP 40.604
630 5TO8 7FM 40.7801
631 4USF 6UI 40.9241
632 3C1X CKK 40.9241
633 6E2O S0L 41.0169
634 4M69 ANP 41.5842
635 4L3L 5FI 41.5842
636 4KS7 X4Z 41.7808
637 1U59 STU 41.8118
638 4UXL 5P8 41.9142
639 5UPK ANP 41.9142
640 2Y6O 1N1 41.9244
641 5WO4 B7V 42.3841
642 3TKI S25 42.5743
643 2HY0 306 42.5743
644 4FF8 14S 42.5743
645 5WNL STU 42.9043
646 3BU5 ATP 42.9043
647 1IR3 ANP 42.9043
648 2WQN ADP 42.9043
649 6F3G CJN 43.0508
650 1JPA ANP 43.2343
651 3EKK GS2 43.2343
652 4U0I 0LI 43.2343
653 5XVG 8FX 43.3447
654 2XVD AS6 43.3775
655 5NKB 8ZT 43.5644
656 4AG8 AXI 43.5644
657 4ASE AV9 43.5644
658 4Y93 746 43.5644
659 3NW7 LGV 43.8944
660 2X2M X2M 43.8944
661 1K3A ACP 44.1472
662 4P5Z Q7M 44.2244
663 6C7Y ADP 44.4056
664 6GQM F8H 44.5545
665 1OPK P16 44.5545
666 4YZN 4K5 44.5993
667 3KMW ATP 45.7565
668 2OO8 RAJ 45.8746
669 5HES 032 46.2046
670 5JKG 6LF 46.2046
671 5MJA 7O3 46.5347
672 4K33 ACP 47.5248
673 3BZ3 YAM 48.1884
674 5FBN 5WF 48.3395
675 3RI1 3RH 48.5149
676 5UR1 YY9 48.5149
677 2PVF ACP 48.5149
678 4XV1 904 48.9726
679 4TWP AXI 49.0775
680 3GQI ACP 49.505
681 4CSV STI 49.8182
682 1BYG STU 50
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