Receptor
PDB id Resolution Class Description Source Keywords
3TLJ 2.2 Å EC: 2.1.1.- CRYSTAL STRUCTURE OF TRM14 FROM PYROCOCCUS FURIOSUS IN COMPL ADENOSYL-L-HOMOCYSTEINE PYROCOCCUS FURIOSUS ROSSMANN FOLD METHYLTRANSFERASE THUMP DOMAIN TRNA METHYLTRANSFERASE TRANSFERASE
Ref.: CRYSTAL STRUCTURES OF THE TRNA:M2G6 METHYLTRANSFERA TRM14/TRMN FROM TWO DOMAINS OF LIFE. NUCLEIC ACIDS RES. V. 40 5149 2012
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ACT A:402;
Invalid;
none;
submit data
59.044 C2 H3 O2 CC(=O...
SAH A:401;
B:401;
Valid;
Valid;
none;
none;
submit data
384.411 C14 H20 N6 O5 S c1nc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3TLJ 2.2 Å EC: 2.1.1.- CRYSTAL STRUCTURE OF TRM14 FROM PYROCOCCUS FURIOSUS IN COMPL ADENOSYL-L-HOMOCYSTEINE PYROCOCCUS FURIOSUS ROSSMANN FOLD METHYLTRANSFERASE THUMP DOMAIN TRNA METHYLTRANSFERASE TRANSFERASE
Ref.: CRYSTAL STRUCTURES OF THE TRNA:M2G6 METHYLTRANSFERA TRM14/TRMN FROM TWO DOMAINS OF LIFE. NUCLEIC ACIDS RES. V. 40 5149 2012
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 57 families.
1 3TM5 - SFG C15 H23 N7 O5 c1nc(c2c(n....
2 3TLJ - SAH C14 H20 N6 O5 S c1nc(c2c(n....
3 3TM4 - SAM C15 H22 N6 O5 S C[S@@+](CC....
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 50 families.
1 3TM5 - SFG C15 H23 N7 O5 c1nc(c2c(n....
2 3TLJ - SAH C14 H20 N6 O5 S c1nc(c2c(n....
3 3TM4 - SAM C15 H22 N6 O5 S C[S@@+](CC....
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 44 families.
1 3TM5 - SFG C15 H23 N7 O5 c1nc(c2c(n....
2 3TLJ - SAH C14 H20 N6 O5 S c1nc(c2c(n....
3 3TM4 - SAM C15 H22 N6 O5 S C[S@@+](CC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAH; Similar ligands found: 197
No: Ligand ECFP6 Tc MDL keys Tc
1 SAH 1 1
2 5X8 0.759494 0.969697
3 A7D 0.734177 0.926471
4 TT8 0.709302 0.970588
5 SXZ 0.692308 0.916667
6 DSH 0.692308 0.914286
7 DTA 0.666667 0.857143
8 3DH 0.662338 0.869565
9 S8M 0.655556 0.901408
10 SFG 0.635294 0.954545
11 SA8 0.62069 0.915493
12 EEM 0.617977 0.890411
13 MTA 0.615385 0.869565
14 SAI 0.613636 0.955882
15 S7M 0.586957 0.916667
16 36A 0.586538 0.90411
17 K15 0.583333 0.878378
18 RAB 0.573333 0.84058
19 ADN 0.573333 0.84058
20 XYA 0.573333 0.84058
21 62X 0.572917 0.855263
22 5CD 0.571429 0.852941
23 0UM 0.5625 0.876712
24 5N5 0.558442 0.84058
25 A4D 0.551282 0.867647
26 SAM 0.537634 0.916667
27 SSA 0.536842 0.712644
28 SMM 0.536842 0.88
29 KB1 0.534653 0.902778
30 A5D 0.532609 0.857143
31 SIB 0.53125 0.928571
32 EP4 0.530864 0.819444
33 DSZ 0.530612 0.732558
34 GSU 0.53 0.752941
35 AMP 0.529412 0.763158
36 A 0.529412 0.763158
37 5CA 0.525773 0.712644
38 ME8 0.524752 0.8125
39 M2T 0.52439 0.821918
40 6RE 0.523256 0.824324
41 GJV 0.522727 0.813333
42 AAT 0.515789 0.863014
43 LSS 0.515152 0.696629
44 KAA 0.514852 0.727273
45 J7C 0.511364 0.835616
46 A5A 0.510417 0.697674
47 SON 0.505495 0.805195
48 SRP 0.505155 0.805195
49 5AL 0.5 0.779221
50 VMS 0.5 0.681818
51 KH3 0.5 0.866667
52 ADX 0.5 0.694118
53 CA0 0.5 0.769231
54 AMP MG 0.5 0.74359
55 AMO 0.5 0.805195
56 54H 0.5 0.681818
57 AHX 0.49505 0.753086
58 TSB 0.494949 0.689655
59 53H 0.494949 0.674157
60 G5A 0.494737 0.712644
61 A2D 0.494382 0.74359
62 ABM 0.494382 0.74359
63 ZAS 0.494253 0.808219
64 A6D 0.490196 0.759494
65 8QN 0.49 0.779221
66 GEK 0.49 0.956522
67 GAP 0.489583 0.769231
68 A3S 0.48913 0.884058
69 AN2 0.48913 0.734177
70 S4M 0.488889 0.831169
71 SRA 0.488636 0.746835
72 LAD 0.485437 0.810127
73 52H 0.484848 0.674157
74 A12 0.483516 0.759494
75 BA3 0.483516 0.74359
76 AP2 0.483516 0.759494
77 AOC 0.483146 0.842857
78 NEC 0.483146 0.788732
79 Y3J 0.481481 0.768116
80 NVA LMS 0.480392 0.696629
81 VRT 0.479167 0.861111
82 50T 0.478723 0.734177
83 5AS 0.478261 0.655556
84 B4P 0.478261 0.74359
85 ADP 0.478261 0.74359
86 AP5 0.478261 0.74359
87 A3N 0.477778 0.830986
88 YSA 0.476636 0.712644
89 XAH 0.476636 0.768293
90 0XU 0.473684 0.897059
91 WAQ 0.471154 0.807692
92 NSS 0.470588 0.712644
93 5AD 0.468354 0.791045
94 ADP MG 0.468085 0.734177
95 AU1 0.468085 0.725
96 M33 0.468085 0.734177
97 MAO 0.467391 0.797468
98 TXA 0.466667 0.759494
99 A3G 0.466667 0.871429
100 NB8 0.466667 0.775
101 3AM 0.465909 0.727273
102 DAL AMP 0.465347 0.779221
103 ATP 0.463158 0.74359
104 ADP BEF 0.463158 0.716049
105 A3T 0.463158 0.842857
106 BEF ADP 0.463158 0.716049
107 ACP 0.463158 0.746835
108 7D7 0.4625 0.785714
109 LEU LMS 0.461538 0.677778
110 APC 0.458333 0.759494
111 AQP 0.458333 0.74359
112 APR 0.458333 0.766234
113 PRX 0.458333 0.746835
114 AR6 0.458333 0.766234
115 5FA 0.458333 0.74359
116 IOT 0.456897 0.761905
117 4AD 0.456311 0.794872
118 PAJ 0.456311 0.722892
119 WSA 0.45614 0.72093
120 FA5 0.453704 0.805195
121 YAP 0.453704 0.794872
122 RBY 0.453608 0.782051
123 ADV 0.453608 0.782051
124 ADP PO3 0.453608 0.763158
125 AD9 0.453608 0.725
126 SAP 0.453608 0.728395
127 AGS 0.453608 0.728395
128 PTJ 0.45283 0.731707
129 MHZ 0.452632 0.797468
130 00A 0.451923 0.740741
131 A3P 0.451613 0.74026
132 YLP 0.451327 0.771084
133 7MD 0.45045 0.768293
134 ALF ADP 0.45 0.707317
135 ADP ALF 0.45 0.707317
136 ATP MG 0.44898 0.734177
137 2VA 0.447917 0.819444
138 OOB 0.446602 0.779221
139 ANP 0.444444 0.725
140 ACQ 0.444444 0.746835
141 TAT 0.444444 0.7375
142 P5A 0.443396 0.719101
143 7D5 0.443182 0.708861
144 ARG AMP 0.442478 0.759036
145 A1R 0.442308 0.7625
146 YLC 0.439655 0.790123
147 2AM 0.438202 0.717949
148 DLL 0.438095 0.779221
149 A22 0.436893 0.734177
150 D3Y 0.436893 0.859155
151 TYR AMP 0.436364 0.782051
152 ATF 0.435644 0.716049
153 MYR AMP 0.435185 0.746988
154 SO8 0.434343 0.808219
155 3UK 0.433962 0.769231
156 OAD 0.433962 0.769231
157 TAD 0.433628 0.765432
158 25A 0.432692 0.74359
159 ANP MG 0.431373 0.707317
160 VO4 ADP 0.431373 0.734177
161 ADP VO4 0.431373 0.734177
162 9SN 0.431193 0.731707
163 TYM 0.431034 0.805195
164 PR8 0.429907 0.8
165 ADQ 0.428571 0.746835
166 YLB 0.42735 0.771084
167 3OD 0.425926 0.769231
168 FYA 0.425926 0.779221
169 1ZZ 0.425926 0.746988
170 PPS 0.425743 0.674419
171 NVA 2AD 0.424242 0.808219
172 MAP 0.423077 0.707317
173 A2P 0.421053 0.727273
174 4YB 0.421053 0.735632
175 ADP BMA 0.420561 0.746835
176 5SV 0.419048 0.731707
177 3NZ 0.416667 0.824324
178 YLA 0.416667 0.771084
179 48N 0.413793 0.753086
180 LPA AMP 0.413793 0.768293
181 AYB 0.413223 0.761905
182 QQY 0.413043 0.696203
183 ACK 0.413043 0.710526
184 JB6 0.412844 0.7625
185 BIS 0.412844 0.719512
186 PAP 0.41 0.730769
187 OVE 0.408602 0.7125
188 4UV 0.40708 0.75
189 AMP DBH 0.40708 0.746835
190 3AD 0.406977 0.852941
191 AF3 ADP 3PG 0.40678 0.743902
192 OMR 0.40678 0.738095
193 LAQ 0.405172 0.768293
194 A A 0.40367 0.74359
195 7C5 0.403509 0.789474
196 7MC 0.403361 0.75
197 4UU 0.4 0.75
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3TLJ; Ligand: SAH; Similar sites found: 501
This union binding pocket(no: 1) in the query (biounit: 3tlj.bio1) has 25 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1WUW TSU 0.00509 0.45353 None
2 2B4Q NAP 0.003507 0.41602 1.08696
3 3D3W NAP 0.004567 0.41502 1.22951
4 1PR9 NAP 0.005349 0.41211 1.22951
5 4U8P FDA 0.01808 0.41405 1.34048
6 4U8P UDP 0.01913 0.41405 1.34048
7 2JAH NDP 0.007855 0.40262 1.34048
8 1JQ3 AAT 0.000101 0.42071 1.35135
9 2V6G NAP 0.006248 0.4068 1.37363
10 2AE2 PTO 0.005996 0.41759 1.53846
11 2AE2 NAP 0.005996 0.41759 1.53846
12 2EWM NAD 0.002823 0.42131 1.60643
13 5I39 FAD 0.004 0.42316 1.60858
14 3K7M FAD 0.008924 0.4202 1.60858
15 2V3A FAD 0.01082 0.40447 1.60858
16 2V3B FAD 0.01111 0.40295 1.60858
17 2IV2 MGD 0.01133 0.40155 1.60858
18 3AB1 FAD 0.006258 0.41678 1.66667
19 1WVG APR 0.005825 0.40119 1.67131
20 5XVK SAH 0.0007425 0.43439 1.76056
21 4NTD FAD 0.008308 0.40944 1.76471
22 3U4C NDP 0.001568 0.42921 1.77936
23 4TQG NDP 0.0007408 0.44276 1.85759
24 5JJR SAH 0.0000006533 0.52743 1.87668
25 4UCI SAM 0.000008722 0.49399 1.87668
26 3L9W AMP 0.00006361 0.49046 1.87668
27 3L9W GSH 0.0001634 0.47008 1.87668
28 5F8F SFG 0.0001963 0.42824 1.87668
29 4BJZ P3A 0.02769 0.40708 1.87668
30 4AT0 FAD 0.01844 0.40223 1.87668
31 2YY7 NAD 0.00207 0.42698 1.92308
32 4HA6 FAD 0.01205 0.40712 1.9685
33 4BV6 FAD 0.01143 0.40632 2.0284
34 1R6D NAD 0.0115 0.41523 2.07715
35 1R6D DAU 0.01352 0.41133 2.07715
36 4ZCC FAD 0.009668 0.41712 2.08333
37 4ZCC NAI 0.009668 0.41712 2.08333
38 4N49 SAM 0.000002857 0.52073 2.14477
39 2Z3Y F2N 0.001291 0.4497 2.14477
40 3C6K MTA 0.001553 0.43858 2.14477
41 3C6K SPD 0.001553 0.43858 2.14477
42 1GET FAD 0.01007 0.42522 2.14477
43 1GET NAP 0.01069 0.42522 2.14477
44 1KNR FAD 0.007368 0.41369 2.14477
45 5MZI FYK 0.01706 0.41155 2.14477
46 5MZI FAD 0.01652 0.41155 2.14477
47 1T9D P25 0.02907 0.41015 2.14477
48 3OZ2 FAD 0.00913 0.40963 2.14477
49 1T9D FAD 0.01095 0.40619 2.14477
50 1T9D PYD 0.03535 0.4061 2.14477
51 3GD4 NAD 0.0209 0.41442 2.15264
52 3GD4 FAD 0.01382 0.41442 2.15264
53 4ITU NAI 0.001568 0.4347 2.23048
54 4ITU 1HS 0.002697 0.4347 2.23048
55 1H5Q NAP 0.0007118 0.44644 2.26415
56 4C3Y FAD 0.003843 0.427 2.26415
57 4C3Y ANB 0.005345 0.42533 2.26415
58 2P41 SAH 0.000002446 0.50946 2.29508
59 1U7T TDT 0.003228 0.4303 2.29885
60 4Q9N NAI 0.008418 0.40135 2.34899
61 2WSB NAD 0.003529 0.4276 2.3622
62 1B74 DGN 0.04719 0.40144 2.3622
63 2Q46 NAP 0.00542 0.40677 2.37154
64 5MW4 5JU 0.000004093 0.55502 2.39521
65 3PT9 SAH 0.00000004892 0.57227 2.41287
66 2HQM FAD 0.005583 0.42087 2.41287
67 1RYI FAD 0.006357 0.41746 2.41287
68 3UOY FAD 0.0155 0.41716 2.41287
69 3UOY NAP 0.0155 0.41716 2.41287
70 1NAA 6FA 0.00776 0.41552 2.41287
71 1NAA ABL 0.01133 0.41552 2.41287
72 5WGR FAD 0.006745 0.41536 2.41287
73 1GPE FAD 0.008625 0.41527 2.41287
74 4MIG G3F 0.01051 0.41393 2.41287
75 5HSA FAS 0.009574 0.40968 2.41287
76 1FP1 SAH 0.00003077 0.45582 2.41935
77 5JGL SAM 0.00001273 0.47549 2.42215
78 1ZBQ NAD 0.008602 0.40217 2.44648
79 3GCZ SAM 0.0000009533 0.52244 2.48227
80 3EVG SAH 0.00000103 0.52148 2.54545
81 4A6D SAM 0.0002563 0.43934 2.54958
82 1N4W FAD 0.007673 0.41574 2.57937
83 3TKA SAM 0.00001083 0.49864 2.59366
84 5CUQ NSC 0.000003464 0.54533 2.62172
85 2O07 MTA 0.0009013 0.43769 2.63158
86 2O07 SPD 0.001064 0.43769 2.63158
87 5N5D SAM 0.00002415 0.47833 2.65487
88 3QOX SAH 0.0000006471 0.55845 2.68097
89 3VSE SAH 0.000003646 0.46719 2.68097
90 4RPL 3UC 0.004261 0.44309 2.68097
91 4RPL FAD 0.004207 0.44139 2.68097
92 3HDY FAD 0.005608 0.43433 2.68097
93 3HDY GDU 0.006094 0.43335 2.68097
94 3HDY FDA 0.005892 0.43335 2.68097
95 5FJN FAD 0.003933 0.42753 2.68097
96 5FJN BE2 0.004551 0.42753 2.68097
97 1H82 GZZ 0.009146 0.42461 2.68097
98 1H82 FAD 0.007682 0.42461 2.68097
99 4RVG TYD 0.01262 0.40622 2.68097
100 4RVG SAM 0.01204 0.40533 2.68097
101 2YVF NAD 0.03026 0.40071 2.68097
102 2YVF FAD 0.02935 0.40071 2.68097
103 3TKY SAH 0.00008223 0.45839 2.71739
104 5FA5 MTA 0.000007486 0.47757 2.7248
105 3H8V ATP 0.0002965 0.43386 2.73973
106 1XTP SAI 0.00007532 0.45282 2.75591
107 2OBF SAH 0.00266 0.43496 2.76817
108 2OBF F83 0.00266 0.43496 2.76817
109 1E1M FAD 0.01439 0.41084 2.82609
110 1E1M NAP 0.01439 0.41084 2.82609
111 1E6E FAD 0.009216 0.40541 2.82609
112 1XKQ NDP 0.004198 0.41658 2.85714
113 1UAY ADN 0.0002601 0.41501 2.89256
114 4GQB 0XU 0.000004955 0.52489 2.90698
115 2EJU SAH 0.000003952 0.50176 2.94906
116 4KRI SAH 0.0000287 0.47975 2.94906
117 2IVD FAD 0.001797 0.43587 2.94906
118 4FWE FAD 0.003141 0.43278 2.94906
119 4GUT FAD 0.003934 0.43122 2.94906
120 4HSU FAD 0.003801 0.43007 2.94906
121 4GUS FAD 0.004375 0.42738 2.94906
122 4JDR FAD 0.003977 0.42634 2.94906
123 4EUE NAI 0.003466 0.41886 2.94906
124 5EZ7 FAD 0.008434 0.41016 2.94906
125 2C7G ODP 0.01942 0.40564 2.94906
126 1DMR PGD 0.02766 0.40545 2.94906
127 3NTD FAD 0.0119 0.40268 2.94906
128 2C7G FAD 0.02353 0.40254 2.94906
129 4EMI FAD 0.01243 0.40186 2.94906
130 4EMI NAD 0.02772 0.40186 2.94906
131 1YKJ FAD 0.03002 0.40147 2.94906
132 1YKJ PHB 0.03002 0.40147 2.94906
133 3NTA FAD 0.01298 0.40104 2.94906
134 3FZG SAM 0.0001064 0.49764 3
135 3G2O SAM 0.0000001625 0.61074 3.01003
136 1ZGA SAH 0.0002011 0.42136 3.08123
137 3O03 NAP 0.003227 0.41326 3.09278
138 4R6W PC 0.001276 0.45734 3.10078
139 4R6W SAH 0.000428 0.45716 3.10078
140 1D1Q 4NP 0.02793 0.40733 3.10559
141 3A4V NAD 0.003807 0.4219 3.15457
142 3A4V PYR 0.003807 0.4219 3.15457
143 3ZV6 4HB 0.009035 0.41171 3.20285
144 3ZV6 NAD 0.008604 0.41171 3.20285
145 4X9M FAD 0.002136 0.43707 3.21716
146 1V59 FAD 0.00342 0.43301 3.21716
147 2WPF FAD 0.01883 0.42419 3.21716
148 2WPF WPF 0.02696 0.41791 3.21716
149 1LVL FAD 0.008289 0.41426 3.21716
150 1LVL NAD 0.002459 0.40559 3.21716
151 4YNU FAD 0.01379 0.40539 3.21716
152 4YNU LGC 0.01631 0.40539 3.21716
153 3MJE NDP 0.007515 0.40216 3.21716
154 2WA2 SAM 0.0000005702 0.5217 3.26087
155 4YUW S4M 0.001476 0.4796 3.28947
156 4YUW 4JU 0.00151 0.4796 3.28947
157 4USR FAD 0.008525 0.40352 3.3241
158 1IY8 NAD 0.004109 0.41446 3.37079
159 1OC2 NAD 0.02632 0.40032 3.44828
160 1OC2 TDX 0.02632 0.40032 3.44828
161 4YAG NAI 0.002427 0.4367 3.46021
162 1MO9 FAD 0.01301 0.4262 3.48525
163 1MO9 KPC 0.01419 0.42492 3.48525
164 1ZMD FAD 0.005875 0.42083 3.48525
165 1Q9I TEO 0.01054 0.41909 3.48525
166 1E5Q NDP 0.002753 0.41903 3.48525
167 1D4D FAD 0.006595 0.41863 3.48525
168 3LAD FAD 0.007411 0.41548 3.48525
169 3UCL CYH 0.01677 0.41438 3.48525
170 3UCL NAP 0.0183 0.41438 3.48525
171 3UCL FAD 0.01677 0.41438 3.48525
172 1YBH FAD 0.009116 0.40869 3.48525
173 1ZMD NAI 0.005056 0.40372 3.48525
174 1GEG NAD 0.007134 0.4031 3.51562
175 1UDB NAD 0.008999 0.41852 3.5503
176 5K7U SAM 0.0003321 0.43328 3.55556
177 4XUC 43G 0.00005589 0.4975 3.66972
178 4XUC SAM 0.00005589 0.4975 3.66972
179 2ZFU SAH 0.001261 0.41631 3.72093
180 3CGB FAD 0.002745 0.42912 3.75
181 1Y8Q ATP 0.0007972 0.43492 3.75335
182 1QO8 FAD 0.007424 0.41545 3.75335
183 3GDN HBX 0.01208 0.41278 3.75335
184 3GDN FAD 0.008541 0.41278 3.75335
185 2RAB NAD 0.01878 0.4127 3.75335
186 2RAB FAD 0.00942 0.4127 3.75335
187 5EB4 FAD 0.009178 0.40953 3.75335
188 5JCA FAD 0.01051 0.40883 3.75335
189 4KGD TDP 0.0318 0.40317 3.75335
190 5JCA NDP 0.02695 0.40304 3.75335
191 3LXD FAD 0.01003 0.40276 3.75335
192 4KGD FAD 0.03333 0.40276 3.75335
193 5IL1 SAM 0.00007666 0.45601 3.77358
194 1JNR FAD 0.03775 0.40229 4
195 3S1S SAH 0.0000005436 0.56152 4.02145
196 3NYC FAD 0.002489 0.44351 4.02145
197 3NYC IAR 0.002489 0.44351 4.02145
198 2FR1 NDP 0.002101 0.42803 4.02145
199 3AXB FAD 0.003567 0.42422 4.02145
200 3AXB PRO 0.004681 0.42422 4.02145
201 3S5W FAD 0.00255 0.42317 4.02145
202 3KLJ FAD 0.005462 0.41173 4.02145
203 2GVC FAD 0.006985 0.40719 4.02145
204 2GV8 FAD 0.007759 0.40641 4.02145
205 2BGM NAJ 0.004762 0.40628 4.02145
206 1VQW FAD 0.008231 0.40417 4.02145
207 5T2U NAP 0.003547 0.41968 4.03226
208 1ORR NAD 0.00515 0.41281 4.03458
209 2XG5 EC2 0.01949 0.41449 4.04624
210 2XG5 EC5 0.01949 0.41449 4.04624
211 3AY6 NAI 0.01011 0.40472 4.08922
212 3AY6 BGC 0.01981 0.40238 4.08922
213 2BD0 NAP 0.004509 0.41403 4.09836
214 1EFV AMP 0.007657 0.42539 4.12698
215 1EFV FAD 0.007657 0.42539 4.12698
216 3BXO SAM 0.000004149 0.47567 4.1841
217 3C3Y SAH 0.0001082 0.45616 4.21941
218 1BXK NAD 0.004906 0.40858 4.22535
219 2RGO FAD 0.001078 0.44657 4.28954
220 1ZK7 FAD 0.002567 0.43851 4.28954
221 4TM3 FAD 0.01656 0.4164 4.28954
222 1BZL FAD 0.02918 0.41542 4.28954
223 2Y6Q I7T 0.008988 0.41532 4.28954
224 2Y6Q FAD 0.004203 0.41532 4.28954
225 2RGH FAD 0.009636 0.40861 4.28954
226 4G74 FAD 0.01014 0.40363 4.28954
227 4G74 UQ5 0.01811 0.40259 4.28954
228 4PIO SAH 0.0005256 0.45615 4.33437
229 4PIO AVI 0.000528 0.45471 4.33437
230 3GMB FAD 0.003087 0.42346 4.33735
231 3ABI NAD 0.003678 0.41516 4.38356
232 3QWI CUE 0.01364 0.40295 4.44444
233 3QWI NAP 0.008243 0.40295 4.44444
234 1HDR NAD 0.02122 0.40028 4.5082
235 3HVJ 705 0.000142 0.48439 4.52489
236 1SB8 NAD 0.005366 0.42611 4.54545
237 1SB8 UD2 0.006343 0.42611 4.54545
238 2PZM NAD 0.01217 0.40692 4.54545
239 2PZM UDP 0.01217 0.40692 4.54545
240 4HXY NDP 0.000835 0.44353 4.55764
241 4RSL FAD 0.00202 0.43369 4.55764
242 2VVM FAD 0.002814 0.43187 4.55764
243 2VVL FAD 0.004729 0.42306 4.55764
244 4J1Q NDP 0.002824 0.41713 4.55764
245 3IHG FAD 0.005001 0.40823 4.55764
246 2NPX NAD 0.01909 0.40802 4.55764
247 2NPX FAD 0.00848 0.40802 4.55764
248 2WET FAD 0.01284 0.4041 4.55764
249 4CQM NAP 0.006135 0.40585 4.5977
250 1NW5 SAM 0.00000000861 0.60986 4.70219
251 3AYI FAD 0.02135 0.40237 4.71567
252 3AYI HCI 0.02213 0.40237 4.71567
253 5THY SAH 0.000006284 0.50711 4.82574
254 3GF4 FAD 0.004476 0.43446 4.82574
255 3SQP FAD 0.03322 0.42869 4.82574
256 2BRY FAD 0.003247 0.4213 4.82574
257 3GF4 UPG 0.01033 0.42019 4.82574
258 4IV9 FAD 0.005457 0.41937 4.82574
259 4TXI FAD 0.003399 0.41921 4.82574
260 4E70 N7I 0.0007558 0.40124 4.82574
261 3QVP FAD 0.01703 0.40048 4.82574
262 3VYW SAM 0.00002377 0.48543 4.87013
263 1EDO NAP 0.004913 0.41245 4.91803
264 2DTX BMA 0.004921 0.42031 4.92424
265 2PT9 S4M 0.0004388 0.44727 4.98442
266 2PT9 2MH 0.0008588 0.44708 4.98442
267 3CTY FAD 0.001743 0.44497 5.01567
268 2HNK SAH 0.0001096 0.45952 5.02092
269 5KOK SAH 0.00001504 0.48547 5.09383
270 5KOK S9T 0.0002344 0.47105 5.09383
271 5KOK R9T 0.0004994 0.45574 5.09383
272 5BVA FAD 0.003711 0.43053 5.09383
273 1FEC FAD 0.01037 0.41256 5.09383
274 4MOP 2H5 0.01653 0.4074 5.09383
275 2AG5 NAD 0.006448 0.40495 5.28455
276 1T57 FMN 0.002385 0.41043 5.33981
277 1GTE FAD 0.01197 0.4186 5.36193
278 1PN0 IPH 0.009655 0.41558 5.36193
279 1PN0 FAD 0.009259 0.41558 5.36193
280 3LZW FAD 0.00631 0.41461 5.36193
281 3LZW NAP 0.01369 0.41461 5.36193
282 3GWZ SAH 0.00004657 0.44048 5.42005
283 3GXO SAH 0.00007564 0.44047 5.42005
284 2AOT SAH 0.0002143 0.42824 5.47945
285 1REO FAD 0.003677 0.4258 5.55556
286 2PXX SAH 0.00002449 0.47725 5.5814
287 5DNK SAH 0.0003565 0.40065 5.59567
288 3RFV 15L 0.005256 0.40451 5.61798
289 3RFV NAI 0.006392 0.40242 5.61798
290 5J60 FAD 0.003162 0.42968 5.625
291 1UWK URO 0.0004507 0.47182 5.63003
292 1UWK NAD 0.0004507 0.47182 5.63003
293 3CGD NAD 0.01262 0.42631 5.63003
294 3CGD FAD 0.01262 0.42631 5.63003
295 3CGD COA 0.01262 0.42631 5.63003
296 2I7C AAT 0.0008129 0.44678 5.65371
297 3ELW GP3 0.00001054 0.53987 5.66667
298 3ELW SAM 0.000009828 0.53987 5.66667
299 1XHL NDP 0.001442 0.43493 5.72391
300 3EVF SAH 0.00002078 0.51879 5.77617
301 3EVF GTA 0.00002851 0.51711 5.77617
302 2R4J FAD 0.003251 0.43913 5.89812
303 2R4J 13P 0.003251 0.43913 5.89812
304 5G3U FDA 0.009891 0.40616 5.89812
305 3FPF MTA 0.00004162 0.51 6.04027
306 3FPF TNA 0.00004162 0.51 6.04027
307 3LCV SAM 0.00006241 0.478 6.04982
308 3WGT QSC 0.009708 0.41547 6.05187
309 3WGT FAD 0.009309 0.41547 6.05187
310 1QAN SAH 0.000002348 0.53058 6.14754
311 3A27 SAM 0.00001202 0.48347 6.16622
312 3E1T FAD 0.004419 0.42627 6.16622
313 5MBX SP5 0.006969 0.42579 6.16622
314 5MBX FAD 0.006969 0.42579 6.16622
315 1KYZ SAH 0.0004653 0.42428 6.16622
316 1KYZ FER 0.006717 0.40152 6.16622
317 2AQJ FAD 0.0292 0.40019 6.16622
318 2AQJ TRP 0.02829 0.40019 6.16622
319 2Q1W NAD 0.003818 0.41832 6.30631
320 1RP0 AHZ 0.005507 0.41036 6.33803
321 1XCL SAH 0.00128 0.43711 6.38298
322 1X87 NAD 0.0003297 0.44869 6.43432
323 3ML1 MGD 0.03463 0.40251 6.43432
324 2BZG SAH 0.000009309 0.48594 6.46552
325 1ZEM NAD 0.003675 0.41093 6.48855
326 4POO SAM 0.000001886 0.54199 6.5
327 1O97 AMP 0.0153 0.41105 6.5625
328 1O97 FAD 0.0153 0.41105 6.5625
329 4DMG SAM 0.00005182 0.52442 6.61578
330 5E1M SAH 0.001321 0.43913 6.639
331 5E1M PRO PRO LYS ARG ILE ALA 0.001321 0.43913 6.639
332 5BR7 FAD 0.006173 0.43242 6.70241
333 5BR7 FLC 0.007333 0.42901 6.70241
334 4CNK FAD 0.005424 0.41744 6.70241
335 5BUK FAD 0.01182 0.40836 6.70241
336 4XQC NAD 0.01277 0.406 6.70241
337 2NVK FAD 0.0122 0.40507 6.70241
338 1XSE NDP 0.01079 0.40647 6.77966
339 1I8T FAD 0.003548 0.42647 6.81199
340 3PFG TLO 0.00006349 0.50335 6.84411
341 3PFG SAM 0.003401 0.45734 6.84411
342 1E3W NAD 0.002642 0.42117 6.89655
343 2VDV SAM 0.00000006931 0.6528 6.91057
344 1G60 SAM 0.000000004771 0.61885 6.92308
345 5MPT SAH 0.00002611 0.47279 6.97051
346 2GN4 NDP 0.01107 0.43745 6.97051
347 2GN4 UD1 0.01875 0.42759 6.97051
348 2DKH 3HB 0.006495 0.41508 6.97051
349 2DKH FAD 0.004553 0.41508 6.97051
350 3NKS FAD 0.009931 0.40506 6.97051
351 3CH6 311 0.009661 0.42352 6.99301
352 3CH6 NAP 0.009661 0.42352 6.99301
353 1Z3C SA8 0.0001284 0.47608 7.04698
354 5THZ SAH 0.000007365 0.51563 7.23861
355 5X62 SAH 0.0000143 0.47424 7.23861
356 4M52 FAD 0.01211 0.40613 7.23861
357 1G55 SAH 0.00000004387 0.62774 7.28863
358 5XVQ SAH 0.000335 0.44841 7.39437
359 3RJ5 NAD 0.008498 0.40901 7.48031
360 1XDS SAM 0.000006976 0.55887 7.48663
361 4D7E FAD 0.002124 0.43276 7.5067
362 4USQ FAD 0.006451 0.40983 7.5067
363 2YG3 FAD 0.009382 0.40912 7.5067
364 4OPC FDA 0.04753 0.4055 7.5067
365 3V1U NAD 0.006184 0.40012 7.5067
366 1P1C SAH 0.0006954 0.43554 7.53769
367 1KPG SAH 0.0001551 0.46615 7.66551
368 1I2B NAD 0.009035 0.4207 7.67327
369 5THQ NDP 0.007682 0.40176 7.72059
370 2YX1 SFG 0.000004887 0.47533 7.7381
371 1QZZ SAM 0.000003375 0.47545 7.7748
372 4D04 FAD 0.02353 0.40637 7.7748
373 4D04 NAP 0.02353 0.40637 7.7748
374 1BC5 SAH 0.002282 0.4146 7.80669
375 5ULP KB1 0.000002034 0.54066 7.83582
376 5BW4 SAM 0.000006317 0.48745 7.86517
377 4J56 FAD 0.006349 0.42026 7.89474
378 1TPY SAH 0.0001412 0.45879 8.01394
379 2CDU FAD 0.003137 0.4255 8.0429
380 4REP FAD 0.009835 0.40726 8.0429
381 3LST SAH 0.00001104 0.54953 8.04598
382 3BGD SAH 0.00002525 0.49393 8.07692
383 3BGD PM6 0.00008257 0.48067 8.07692
384 1FP2 SAH 0.006483 0.41087 8.23864
385 3ICR FAD 0.003811 0.42298 8.31099
386 3ICS FAD 0.004696 0.42015 8.31099
387 3ICT FAD 0.005284 0.41688 8.31099
388 1KPH SAH 0.0001892 0.45399 8.36237
389 1NFQ NAI 0.007488 0.40472 8.46154
390 3GEG NAD 0.0009259 0.4372 8.50202
391 1YQZ FAD 0.00354 0.44204 8.57909
392 4AZW SAM 0.000234 0.44021 8.57909
393 4AZT SAM 0.0002119 0.43658 8.57909
394 5U8U FAD 0.01551 0.41595 8.57909
395 3WMX NAD 0.003432 0.41215 8.65922
396 4FN4 NAD 0.0009835 0.43912 8.66142
397 4MO2 FDA 0.003729 0.42339 8.69565
398 2A14 SAH 0.001586 0.417 8.74525
399 2QA1 FAD 0.005333 0.4145 8.84719
400 5E8J SAH 0.00003102 0.44794 8.97436
401 5E9W SAH 0.00003044 0.44288 8.97436
402 5FTW SAH 0.001275 0.4164 8.98438
403 2ZIF SAM 0.0000000002325 0.66796 9.09091
404 5MGZ SAH 0.0000005197 0.53855 9.11528
405 5KVA SAM 0.00006308 0.47398 9.11528
406 5TTJ FAD 0.005991 0.4166 9.11528
407 1OAA OAA 0.01141 0.40815 9.26641
408 3A25 SAM 0.000008893 0.48728 9.30233
409 4FC7 NAP 0.002936 0.43308 9.38628
410 4FC7 COA 0.002936 0.43308 9.38628
411 4LWP SAH 0.00002939 0.46883 9.51087
412 2Q7V FAD 0.005609 0.41983 9.53846
413 4YSX FAD 0.002866 0.43153 9.57447
414 4KRG SAH 0.000009984 0.47912 9.65147
415 3AFN NAP 0.005 0.41335 9.68992
416 1XHC FAD 0.002551 0.42935 9.80926
417 5LOG SAH 0.00006301 0.46333 9.87124
418 1U2Z SAH 0.00001848 0.49943 9.91957
419 3NUG NAD 0.0008413 0.4434 10.1215
420 1SQF SAM 0.00000003722 0.57596 10.1877
421 2DPM SAM 0.0000001321 0.57993 10.2113
422 5GWX SAR 0.0005714 0.44426 10.2113
423 5GWX SAM 0.0005714 0.44426 10.2113
424 3P9C SAH 0.0009875 0.44186 10.4396
425 5HJM MTA 0.000001977 0.55659 10.5114
426 1LSS NAD 0.0002747 0.44301 10.7143
427 1COY FAD 0.01057 0.4078 10.7239
428 2GDZ NAD 0.0018 0.42814 10.8614
429 1G0N PHH 0.01091 0.40719 10.9541
430 1ELI PYC 0.003134 0.42774 10.992
431 1JG3 ADN 0.00001136 0.48451 11.0638
432 4K5S FAD 0.005768 0.41072 11.194
433 4K5S PM0 0.0124 0.41072 11.194
434 4NBU NAI 0.003444 0.41768 11.2
435 4KIB SAH 0.0000004914 0.52695 11.2045
436 3LKZ SFG 0.000001838 0.5198 11.2601
437 2GAG FOA 0.006162 0.42172 11.2601
438 2GAG FAD 0.006646 0.42027 11.2601
439 2GAG NAD 0.004525 0.41978 11.2601
440 1I9G SAM 0.000001651 0.53109 11.4286
441 5K8V 6RE 0.00003301 0.53041 11.6343
442 4YMH SAH 0.00001449 0.49384 11.6667
443 4BLW AMP 0.00006939 0.49351 11.7647
444 4BLW SAH 0.00005932 0.48479 11.7647
445 5ITV NAI 0.0006255 0.4488 11.7647
446 2E5V FAD 0.008528 0.41372 11.7962
447 1F3L SAH 0.00002619 0.48782 11.838
448 3DXY SAM 0.00006479 0.43731 11.9266
449 5DX1 SFG 0.000008259 0.51799 12.0344
450 5DWQ SFG 0.00003905 0.48833 12.0344
451 5DX0 SFG 0.00004468 0.48794 12.0344
452 5DX8 SFG 0.00004272 0.48467 12.0344
453 5DXA SFG 0.00004675 0.48309 12.0344
454 5GM1 SAH 0.0000334 0.48901 12.1212
455 3H2B SAH 0.00007278 0.45784 12.3153
456 5KMS NAD 0.01921 0.40789 12.3324
457 5KMS FAD 0.008173 0.40765 12.3324
458 1AE1 NAP 0.008352 0.4039 12.4542
459 1YY5 FAD 0.002507 0.43802 12.6005
460 1RSG FAD 0.003006 0.43264 12.6005
461 5JCM NAD 0.02442 0.40682 12.8686
462 5JCM FAD 0.02372 0.40682 12.8686
463 5JCM ISD 0.02442 0.40682 12.8686
464 3Q87 SAM 0.0002331 0.45479 12.9412
465 2XVM SAH 0.000094 0.43123 13.0653
466 1L1E SAH 0.0001372 0.45465 13.2404
467 3MQ2 SAH 0.0000299 0.46177 13.3028
468 4NEC SAH 0.0000067 0.55272 13.4048
469 2HMT NAI 0.0001442 0.45825 13.8889
470 4OBW SAM 0.00003342 0.4647 14.0078
471 3AD8 NAD 0.00314 0.42314 14.7783
472 3AD8 PYC 0.01488 0.41739 14.7783
473 3AD8 FAD 0.01488 0.41739 14.7783
474 1I1N SAH 0.000000201 0.58887 15.0442
475 3LU1 NAD 0.004159 0.41292 15.3846
476 1VE3 SAM 0.000007572 0.48831 15.4185
477 3MB5 SAM 0.000003214 0.53023 15.6863
478 1EK6 NAI 0.02242 0.40212 15.8046
479 2PX8 SAH 0.00002768 0.46914 15.9851
480 4NTC FAD 0.009611 0.40961 16.1194
481 3P2E SAH 0.00001362 0.49363 16.4444
482 3OU2 SAH 0.00005291 0.46623 16.5138
483 3JWH SAH 0.000003364 0.46907 16.5899
484 3T7S SAM 0.000001465 0.51715 17.1642
485 2F5Z FAD 0.006566 0.41871 17.1875
486 4YRY FAD 0.006835 0.41702 17.3913
487 4YRY NAD 0.02155 0.4029 17.3913
488 1L3I SAH 0.000002041 0.54508 17.7083
489 1GY8 NAD 0.008663 0.40082 18.3879
490 4PNE SAH 0.00007495 0.47477 18.8742
491 1DL5 SAH 0.0000009475 0.55881 19.3029
492 5JE0 AZ8 0.00002966 0.50437 20.2429
493 5JE0 SAH 0.00002966 0.50437 20.2429
494 1R18 SAH 0.00000007553 0.58862 20.7048
495 1Q0S SAH 0.0000002976 0.57469 21.2355
496 5L95 AMP 0.0005941 0.42646 21.25
497 4DCM SAM 0.00003362 0.45464 21.9839
498 2PWY SAH 0.000001057 0.54981 22.4806
499 5FA8 SAM 0.0000007396 0.5561 23.6025
500 5E72 SAM 0.000000002694 0.64627 35.2601
501 3RNM FAD 0.007645 0.41581 39.6552
Pocket No.: 2; Query (leader) PDB : 3TLJ; Ligand: SAH; Similar sites found: 51
This union binding pocket(no: 2) in the query (biounit: 3tlj.bio2) has 24 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4DSG FAD 0.01822 0.41279 1.60858
2 4DSG UDP 0.01822 0.41279 1.60858
3 3RKR NAP 0.0006386 0.40185 1.60858
4 3F8D FAD 0.02591 0.41087 1.85759
5 5T67 JHZ 0.01073 0.41381 1.87668
6 5T67 SAH 0.008714 0.41333 1.87668
7 5GT9 NAP 0.008105 0.40488 1.90114
8 1A27 NAP 0.008363 0.40303 2.07612
9 1T9D 1MM 0.02486 0.41631 2.14477
10 2CFC NAD 0.005364 0.40993 2.4
11 4OHU NAD 0.02524 0.40359 2.42215
12 4OHU 2TK 0.02524 0.40359 2.42215
13 4O0L NDP 0.004831 0.41451 2.54545
14 2Q2V NAD 0.01119 0.40122 2.7451
15 1NJR XYL 0.007595 0.40216 3.16901
16 5JAQ NAI 0.01282 0.40492 3.21716
17 4EIP FAD 0.01924 0.40152 3.48525
18 2RH4 EMO 0.01651 0.40536 3.61011
19 4L2H AR6 AR6 0.008048 0.40623 3.77358
20 4ZRN NAD 0.007616 0.40961 4.16667
21 4ZRN UPG 0.01769 0.40639 4.16667
22 1Q1R FAD 0.01344 0.40204 4.55764
23 1RL4 BRR 0.02693 0.40377 4.78723
24 1MXH NAP 0.00937 0.40996 5.43478
25 1MXH DHF 0.009465 0.40976 5.43478
26 1HDO NAP 0.004413 0.41989 6.16622
27 2EXX NAP 0.01107 0.40254 6.20915
28 4O1M NAD 0.009178 0.4013 6.66667
29 4XQC 13D 0.0148 0.40666 6.70241
30 1V35 NAI 0.01241 0.40744 6.99088
31 2DKN NAI 0.008328 0.40181 7.05882
32 4D42 W0I 0.02523 0.40008 7.0922
33 4D42 NAP 0.02523 0.40008 7.0922
34 2A8X FAD 0.01845 0.4015 7.23861
35 4OPC PGT 0.03512 0.41698 7.5067
36 1JQD SAH 0.0006337 0.40537 7.53425
37 4J36 1HR 0.01911 0.40081 7.7748
38 4K26 NDP 0.006388 0.40931 7.97101
39 3QFA FAD 0.01156 0.40973 8.62069
40 4NBT NAD 0.009092 0.40019 8.75
41 2XVF FAD 0.0116 0.40486 9.65147
42 2XVE FAD 0.03031 0.40244 9.65147
43 1COY AND 0.02954 0.40107 10.7239
44 1G0N NDP 0.01107 0.40676 10.9541
45 1XG5 NAP 0.005187 0.41319 11.1111
46 4JNA FAD 0.01889 0.40018 12.0588
47 3TN7 NJP 0.005387 0.41249 13.2296
48 4EMJ FAD 0.0111 0.4077 14.0187
49 4II2 ATP 0.00298 0.4064 21.6867
50 1NNU TCT 0.03098 0.4112 38.3333
51 1NNU NAD 0.03028 0.4112 38.3333
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