Receptor
PDB id Resolution Class Description Source Keywords
3QPB 1.82 Å EC: 2.4.2.3 CRYSTAL STRUCTURE OF STREPTOCOCCUS PYOGENES URIDINE PHOSPHOR REVEALS A SUBCLASS OF THE NP-I SUPERFAMILY STREPTOCOCCUS PYOGENES SEROTYPE M6 HEXAMER NP-I SUPERFAMILY PYRIMIDINE SALVAGE PATHWAY URIDIPHOSPHORYLASE TRANSITION STATE TRANSFERASE
Ref.: THE CRYSTAL STRUCTURE OF STREPTOCOCCUS PYOGENES URI PHOSPHORYLASE REVEALS A DISTINCT SUBFAMILY OF NUCLE PHOSPHORYLASES. BIOCHEMISTRY V. 50 6549 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
R1P A:1254;
B:1254;
C:1254;
D:1254;
E:1254;
F:1254;
G:1254;
H:1254;
I:1254;
J:1254;
K:1254;
L:1254;
M:1254;
N:1254;
O:1254;
P:1254;
Q:1254;
R:1254;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
230.11 C5 H11 O8 P C([C@...
URA A:1255;
B:1255;
C:1255;
D:1255;
E:1255;
F:1255;
G:1255;
H:1255;
I:1255;
J:1255;
K:1255;
L:1255;
M:1255;
N:1255;
O:1255;
P:1255;
Q:1255;
R:1255;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
112.087 C4 H4 N2 O2 C1=CN...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3QPB 1.82 Å EC: 2.4.2.3 CRYSTAL STRUCTURE OF STREPTOCOCCUS PYOGENES URIDINE PHOSPHOR REVEALS A SUBCLASS OF THE NP-I SUPERFAMILY STREPTOCOCCUS PYOGENES SEROTYPE M6 HEXAMER NP-I SUPERFAMILY PYRIMIDINE SALVAGE PATHWAY URIDIPHOSPHORYLASE TRANSITION STATE TRANSFERASE
Ref.: THE CRYSTAL STRUCTURE OF STREPTOCOCCUS PYOGENES URI PHOSPHORYLASE REVEALS A DISTINCT SUBFAMILY OF NUCLE PHOSPHORYLASES. BIOCHEMISTRY V. 50 6549 2011
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 3QPB - URA C4 H4 N2 O2 C1=CNC(=O)....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 3QPB - URA C4 H4 N2 O2 C1=CNC(=O)....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 3QPB - URA C4 H4 N2 O2 C1=CNC(=O)....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: R1P; Similar ligands found: 25
No: Ligand ECFP6 Tc MDL keys Tc
1 R1P 1 1
2 M1P 0.852941 0.904762
3 XGP 0.852941 0.904762
4 G1P 0.852941 0.904762
5 GL1 0.852941 0.904762
6 RI2 0.609756 0.926829
7 GFP 0.571429 0.826087
8 GP1 0.571429 0.76
9 NG1 0.48 0.690909
10 GN1 0.48 0.690909
11 ALX 0.465116 0.904762
12 BNX 0.465116 0.904762
13 TRE 0.45 0.622222
14 T6P 0.44 0.844444
15 AMG 0.439024 0.6
16 GYP 0.439024 0.6
17 MBG 0.439024 0.6
18 MMA 0.439024 0.6
19 G16 0.4375 0.840909
20 YO5 0.418605 0.8
21 GPM 0.418605 0.8
22 MVP 0.418182 0.808511
23 PRP 0.411765 0.951219
24 PPC 0.411765 0.886364
25 GMB 0.403846 0.840909
Ligand no: 2; Ligand: URA; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 URA 1 1
2 TUL 0.5 0.725
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: 1
This union binding pocket(no: 1) in the query (biounit: 3qpb.bio1) has 11 residues
No: Leader PDB Ligand Sequence Similarity
1 1JE1 GMP 45.7627
Pocket No.: 2; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: 1
This union binding pocket(no: 2) in the query (biounit: 3qpb.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
1 3BJE R1P 22.3404
Pocket No.: 3; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 3qpb.bio1) has 11 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 3qpb.bio1) has 11 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 3qpb.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 3qpb.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 7; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 7) in the query (biounit: 3qpb.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 8; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 8) in the query (biounit: 3qpb.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 9; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 9) in the query (biounit: 3qpb.bio1) has 11 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 10; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 10) in the query (biounit: 3qpb.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 11; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 11) in the query (biounit: 3qpb.bio1) has 12 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 12; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 12) in the query (biounit: 3qpb.bio1) has 11 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 13; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 13) in the query (biounit: 3qpb.bio3) has 10 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 14; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 14) in the query (biounit: 3qpb.bio3) has 15 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 15; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 15) in the query (biounit: 3qpb.bio3) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 16; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 16) in the query (biounit: 3qpb.bio3) has 11 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 17; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 17) in the query (biounit: 3qpb.bio3) has 11 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 18; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 18) in the query (biounit: 3qpb.bio3) has 11 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 19; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 19) in the query (biounit: 3qpb.bio3) has 11 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 20; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 20) in the query (biounit: 3qpb.bio3) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 21; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 21) in the query (biounit: 3qpb.bio3) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 22; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 22) in the query (biounit: 3qpb.bio3) has 15 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 23; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 23) in the query (biounit: 3qpb.bio3) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 24; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 24) in the query (biounit: 3qpb.bio3) has 11 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 25; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 25) in the query (biounit: 3qpb.bio2) has 11 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 26; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 26) in the query (biounit: 3qpb.bio2) has 11 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 27; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 27) in the query (biounit: 3qpb.bio2) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 28; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 28) in the query (biounit: 3qpb.bio2) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 29; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 29) in the query (biounit: 3qpb.bio2) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 30; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 30) in the query (biounit: 3qpb.bio2) has 11 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 31; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 31) in the query (biounit: 3qpb.bio2) has 11 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 32; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 32) in the query (biounit: 3qpb.bio2) has 11 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 33; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 33) in the query (biounit: 3qpb.bio2) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 34; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 34) in the query (biounit: 3qpb.bio2) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 35; Query (leader) PDB : 3QPB; Ligand: R1P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 35) in the query (biounit: 3qpb.bio2) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 36; Query (leader) PDB : 3QPB; Ligand: URA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 36) in the query (biounit: 3qpb.bio2) has 11 residues
No: Leader PDB Ligand Sequence Similarity
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