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Receptor
PDB id Resolution Class Description Source Keywords
3QOX 2.3 Å EC: 2.1.1.43 DOT1L STRUCTURE IN COMPLEX WITH SAH HOMO SAPIENS H3K79 METHYLATION TRANSFERASE
Ref.: CHEMOGENETIC ANALYSIS OF HUMAN PROTEIN METHYLTRANSF CHEM.BIOL.DRUG DES. V. 78 199 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SAH A:417;
Valid;
none;
Ki = 0.27 uM
384.411 C14 H20 N6 O5 S c1nc(...
SO4 A:418;
A:419;
A:420;
A:421;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3QOX 2.3 Å EC: 2.1.1.43 DOT1L STRUCTURE IN COMPLEX WITH SAH HOMO SAPIENS H3K79 METHYLATION TRANSFERASE
Ref.: CHEMOGENETIC ANALYSIS OF HUMAN PROTEIN METHYLTRANSF CHEM.BIOL.DRUG DES. V. 78 199 2011
Members (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 39 families.
1 3QOW - SAM C15 H22 N6 O5 S C[S@@+](CC....
2 3QOX Ki = 0.27 uM SAH C14 H20 N6 O5 S c1nc(c2c(n....
3 1NW3 - SAM C15 H22 N6 O5 S C[S@@+](CC....
4 4EK9 Ki = 38000 nM EP4 C12 H18 N6 O3 CN(C)C[C@@....
70% Homology Family (14)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 28 families.
1 5MVS ic50 = 190 nM 5JJ C20 H17 Cl2 N3 CCC#CCN(c1....
2 5DTR ic50 = 39 uM 5F7 C17 H14 Cl2 N2 O CN(c1ccc2c....
3 5DT2 ic50 = 150 nM 5EV C26 H23 N5 O Cc1cc2ccc(....
4 5DRY ic50 = 20 nM 5EK C24 H18 Cl2 N8 O2 c1ccc(c(c1....
5 3SR4 Ki = 0.29 uM TT8 C15 H22 N6 O5 S CNc1c2c(nc....
6 5DSX ic50 = 10 nM 5EW C26 H24 Cl N7 O Cc1cc2ccc(....
7 5MW3 ic50 = 190 nM 5JJ C20 H17 Cl2 N3 CCC#CCN(c1....
8 5MW4 Ki = 0.002 nM 5JU C32 H36 Cl N9 O2 S Cc1c(cccn1....
9 5DTM ic50 = 320 uM 5F4 C13 H10 Cl2 N2 O2 CNC(=O)c1c....
10 4WVL - 3US C33 H51 N9 O5 CC(C)N(CCC....
11 3QOW - SAM C15 H22 N6 O5 S C[S@@+](CC....
12 3QOX Ki = 0.27 uM SAH C14 H20 N6 O5 S c1nc(c2c(n....
13 1NW3 - SAM C15 H22 N6 O5 S C[S@@+](CC....
14 4EK9 Ki = 38000 nM EP4 C12 H18 N6 O3 CN(C)C[C@@....
50% Homology Family (14)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 22 families.
1 5MVS ic50 = 190 nM 5JJ C20 H17 Cl2 N3 CCC#CCN(c1....
2 5DTR ic50 = 39 uM 5F7 C17 H14 Cl2 N2 O CN(c1ccc2c....
3 5DT2 ic50 = 150 nM 5EV C26 H23 N5 O Cc1cc2ccc(....
4 5DRY ic50 = 20 nM 5EK C24 H18 Cl2 N8 O2 c1ccc(c(c1....
5 3SR4 Ki = 0.29 uM TT8 C15 H22 N6 O5 S CNc1c2c(nc....
6 5DSX ic50 = 10 nM 5EW C26 H24 Cl N7 O Cc1cc2ccc(....
7 5MW3 ic50 = 190 nM 5JJ C20 H17 Cl2 N3 CCC#CCN(c1....
8 5MW4 Ki = 0.002 nM 5JU C32 H36 Cl N9 O2 S Cc1c(cccn1....
9 5DTM ic50 = 320 uM 5F4 C13 H10 Cl2 N2 O2 CNC(=O)c1c....
10 4WVL - 3US C33 H51 N9 O5 CC(C)N(CCC....
11 3QOW - SAM C15 H22 N6 O5 S C[S@@+](CC....
12 3QOX Ki = 0.27 uM SAH C14 H20 N6 O5 S c1nc(c2c(n....
13 1NW3 - SAM C15 H22 N6 O5 S C[S@@+](CC....
14 4EK9 Ki = 38000 nM EP4 C12 H18 N6 O3 CN(C)C[C@@....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAH; Similar ligands found: 211
No: Ligand ECFP6 Tc MDL keys Tc
1 SAH 1 1
2 5X8 0.759494 0.969697
3 A7D 0.734177 0.926471
4 TT8 0.709302 0.970588
5 DSH 0.692308 0.914286
6 SXZ 0.692308 0.916667
7 DTA 0.666667 0.857143
8 3DH 0.662338 0.869565
9 S8M 0.655556 0.901408
10 SFG 0.635294 0.954545
11 SA8 0.62069 0.915493
12 EEM 0.617977 0.890411
13 MTA 0.615385 0.869565
14 SAI 0.613636 0.955882
15 S7M 0.586957 0.916667
16 36A 0.586538 0.90411
17 K15 0.583333 0.878378
18 ADN 0.573333 0.84058
19 RAB 0.573333 0.84058
20 XYA 0.573333 0.84058
21 62X 0.572917 0.855263
22 5CD 0.571429 0.852941
23 0UM 0.5625 0.876712
24 5N5 0.558442 0.84058
25 A4D 0.551282 0.867647
26 SAM 0.537634 0.916667
27 SMM 0.536842 0.88
28 SSA 0.536842 0.712644
29 KB1 0.534653 0.902778
30 A5D 0.532609 0.857143
31 SIB 0.53125 0.928571
32 EP4 0.530864 0.819444
33 DSZ 0.530612 0.732558
34 GSU 0.53 0.752941
35 A 0.529412 0.763158
36 LMS 0.529412 0.694118
37 AMP 0.529412 0.763158
38 5CA 0.525773 0.712644
39 ME8 0.524752 0.8125
40 M2T 0.52439 0.821918
41 6RE 0.523256 0.824324
42 GJV 0.522727 0.813333
43 AAT 0.515789 0.863014
44 LSS 0.515152 0.696629
45 KAA 0.514852 0.727273
46 J7C 0.511364 0.835616
47 A5A 0.510417 0.697674
48 SON 0.505495 0.805195
49 SRP 0.505155 0.805195
50 F0P 0.504505 0.915493
51 54H 0.5 0.681818
52 VMS 0.5 0.681818
53 ADX 0.5 0.694118
54 CA0 0.5 0.769231
55 AMO 0.5 0.805195
56 5AL 0.5 0.779221
57 KH3 0.5 0.866667
58 NVA LMS 0.49505 0.707865
59 AHX 0.49505 0.753086
60 TSB 0.494949 0.689655
61 53H 0.494949 0.674157
62 G5A 0.494737 0.712644
63 ABM 0.494382 0.74359
64 A2D 0.494382 0.74359
65 ZAS 0.494253 0.808219
66 A6D 0.490196 0.759494
67 8QN 0.49 0.779221
68 GEK 0.49 0.956522
69 GAP 0.489583 0.769231
70 AN2 0.48913 0.734177
71 A3S 0.48913 0.884058
72 S4M 0.488889 0.831169
73 SRA 0.488636 0.746835
74 LAD 0.485437 0.810127
75 52H 0.484848 0.674157
76 A12 0.483516 0.759494
77 BA3 0.483516 0.74359
78 AP2 0.483516 0.759494
79 NEC 0.483146 0.788732
80 AOC 0.483146 0.842857
81 Y3J 0.481481 0.768116
82 VRT 0.479167 0.861111
83 50T 0.478723 0.734177
84 B4P 0.478261 0.74359
85 ADP 0.478261 0.74359
86 5AS 0.478261 0.655556
87 AP5 0.478261 0.74359
88 A3N 0.477778 0.830986
89 YSA 0.476636 0.712644
90 XAH 0.476636 0.768293
91 0XU 0.473684 0.897059
92 AT4 0.473118 0.7375
93 WAQ 0.471154 0.807692
94 NSS 0.470588 0.712644
95 5AD 0.468354 0.791045
96 AU1 0.468085 0.725
97 M33 0.468085 0.734177
98 MAO 0.467391 0.797468
99 TXA 0.466667 0.759494
100 NB8 0.466667 0.775
101 A3G 0.466667 0.871429
102 3AM 0.465909 0.727273
103 DAL AMP 0.465347 0.779221
104 8X1 0.465347 0.707865
105 A3T 0.463158 0.842857
106 ATP 0.463158 0.74359
107 HEJ 0.463158 0.74359
108 ACP 0.463158 0.746835
109 7D7 0.4625 0.785714
110 LEU LMS 0.461538 0.688889
111 9ZA 0.460784 0.740741
112 9ZD 0.460784 0.740741
113 5FA 0.458333 0.74359
114 AQP 0.458333 0.74359
115 AR6 0.458333 0.766234
116 APC 0.458333 0.759494
117 APR 0.458333 0.766234
118 PRX 0.458333 0.746835
119 F2R 0.457627 0.75
120 IOT 0.456897 0.761905
121 4AD 0.456311 0.794872
122 PAJ 0.456311 0.722892
123 WSA 0.45614 0.72093
124 YAP 0.453704 0.794872
125 8PZ 0.453704 0.712644
126 FA5 0.453704 0.805195
127 ADP PO3 0.453608 0.763158
128 ADV 0.453608 0.782051
129 NVA 2AD 0.453608 0.849315
130 SAP 0.453608 0.728395
131 AGS 0.453608 0.728395
132 RBY 0.453608 0.782051
133 AD9 0.453608 0.725
134 PTJ 0.45283 0.731707
135 MHZ 0.452632 0.797468
136 00A 0.451923 0.740741
137 A3P 0.451613 0.74026
138 YLP 0.451327 0.771084
139 7MD 0.45045 0.768293
140 ALF ADP 0.45 0.707317
141 ADP ALF 0.45 0.707317
142 2VA 0.447917 0.819444
143 OOB 0.446602 0.779221
144 ANP 0.444444 0.725
145 T99 0.444444 0.7375
146 ACQ 0.444444 0.746835
147 TAT 0.444444 0.7375
148 P5A 0.443396 0.719101
149 7D5 0.443182 0.708861
150 A1R 0.442308 0.7625
151 YLC 0.439655 0.790123
152 2AM 0.438202 0.717949
153 DLL 0.438095 0.779221
154 ARG AMP 0.4375 0.759036
155 A22 0.436893 0.734177
156 D3Y 0.436893 0.859155
157 ATF 0.435644 0.716049
158 MYR AMP 0.435185 0.746988
159 80F 0.434426 0.75
160 SO8 0.434343 0.808219
161 OAD 0.433962 0.769231
162 3UK 0.433962 0.769231
163 TAD 0.433628 0.765432
164 25A 0.432692 0.74359
165 6YZ 0.431373 0.746835
166 VO4 ADP 0.431373 0.734177
167 ADP VO4 0.431373 0.734177
168 9SN 0.431193 0.731707
169 TYM 0.431034 0.805195
170 B5V 0.429907 0.759494
171 PR8 0.429907 0.8
172 ADQ 0.428571 0.746835
173 YLB 0.42735 0.771084
174 9K8 0.425926 0.67033
175 1ZZ 0.425926 0.746988
176 FYA 0.425926 0.779221
177 3OD 0.425926 0.769231
178 PPS 0.425743 0.674419
179 MAP 0.423077 0.707317
180 A2P 0.421053 0.727273
181 4YB 0.421053 0.735632
182 9X8 0.420561 0.75
183 ADP BMA 0.420561 0.746835
184 TYR AMP 0.419643 0.794872
185 5SV 0.419048 0.731707
186 3NZ 0.416667 0.824324
187 YLA 0.416667 0.771084
188 8Q2 0.415254 0.688889
189 A3R 0.415094 0.7625
190 B5Y 0.414414 0.75
191 B5M 0.414414 0.75
192 48N 0.413793 0.753086
193 LPA AMP 0.413793 0.768293
194 AYB 0.413223 0.761905
195 ACK 0.413043 0.710526
196 QQY 0.413043 0.696203
197 BIS 0.412844 0.719512
198 JB6 0.412844 0.7625
199 PAP 0.41 0.730769
200 DQV 0.408696 0.75641
201 OVE 0.408602 0.7125
202 AMP DBH 0.40708 0.746835
203 4UV 0.40708 0.75
204 3AD 0.406977 0.852941
205 AF3 ADP 3PG 0.40678 0.743902
206 OMR 0.40678 0.738095
207 LAQ 0.405172 0.768293
208 A A 0.40367 0.74359
209 7C5 0.403509 0.789474
210 7MC 0.403361 0.75
211 4UU 0.4 0.75
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3QOX; Ligand: SAH; Similar sites found with APoc: 747
This union binding pocket(no: 1) in the query (biounit: 3qox.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 5FJN BE2 0.938967
2 5FJN FAD 0.938967
3 4G5H NAP 1.10193
4 4G5H UD7 1.10193
5 5U8U FAD 1.17371
6 4KGD TDP 1.17371
7 4KGD FAD 1.17371
8 1E1M NAP 1.17371
9 1E1M FAD 1.17371
10 1BZL GCG 1.17371
11 4BJZ FAD 1.17925
12 4BJZ P3A 1.17925
13 3VSE SAH 1.25628
14 1XHC FAD 1.3624
15 3WMX NAD 1.39665
16 4N49 SAM 1.40845
17 3E1T FAD 1.40845
18 2RAB NAD 1.40845
19 2RAB FAD 1.40845
20 5ZYN FAD 1.40845
21 1LVL NAD 1.40845
22 1YQZ FAD 1.40845
23 2C7G FAD 1.40845
24 2C7G ODP 1.40845
25 1LVL FAD 1.40845
26 6ER9 FAD 1.40845
27 3SSO SAH 1.43198
28 5MPT SAH 1.44928
29 5MIT NAP 1.52905
30 5MIT FAD 1.52905
31 1ZBQ NAD 1.52905
32 5J60 FAD 1.5625
33 1GZ6 NAI 1.5674
34 3C6K SPD 1.5748
35 3C6K MTA 1.5748
36 2EG5 SAH 1.6129
37 5W7R SAH 1.64319
38 1X87 NAD 1.64319
39 3S5W FAD 1.64319
40 2BRY FAD 1.64319
41 5W7R 9Z7 1.64319
42 4TXI FAD 1.64319
43 6FP4 FAD 1.64319
44 6FP4 E1T 1.64319
45 1CZA GLC 1.64319
46 5NMX FAD 1.64706
47 5NMX NAP 1.64706
48 5YF1 SFG 1.65746
49 5YF1 8V0 1.65746
50 4USQ FAD 1.66205
51 3AB1 FAD 1.66667
52 3L9W AMP 1.69492
53 3L9W GSH 1.69492
54 5GWX SAM 1.76056
55 5GWX SAR 1.76056
56 1R18 SAH 1.76211
57 3OU2 SAH 1.83486
58 1BC5 SAH 1.85874
59 2PT9 2MH 1.86916
60 2PT9 S4M 1.86916
61 2ZWA SAH 1.87793
62 4C2C ALA ALA ALA 1.87793
63 1GTE FAD 1.87793
64 6B3A SAM 1.87793
65 4OEV OXL 1.87793
66 1COY FAD 1.87793
67 6CI9 NAP 1.9305
68 5FTW SAH 1.95312
69 1BXK NAD 1.97183
70 2XTZ GSP 1.9774
71 1I2B USQ 1.9802
72 1I2B NAD 1.9802
73 1I2B UPG 1.9802
74 5HJM MTA 1.98864
75 3ZFD ANP 1.9943
76 3ELW SAM 2
77 3ELW GP3 2
78 4URF NAD 2.01613
79 4YAC NAI 2.0202
80 3NUG NAD 2.02429
81 3GF4 FAD 2.05128
82 3GF4 UPG 2.05128
83 4HXY NDP 2.05479
84 1PJS NAD 2.11268
85 1E5Q NDP 2.11268
86 1NJR XYL 2.11268
87 3CGD COA 2.11268
88 3CGD FAD 2.11268
89 4TM3 FAD 2.11268
90 1YY5 FAD 2.11268
91 1RSG FAD 2.11268
92 6F97 FAD 2.11268
93 4D5G TPP 2.11268
94 3CGB FAD 2.11268
95 4D5G FAD 2.11268
96 3CGD NAD 2.11268
97 2E5V FAD 2.11268
98 2AQJ TRP 2.11268
99 2AQJ FAD 2.11268
100 2I7C AAT 2.12014
101 3SJU NDP 2.15054
102 5GWT NAD 2.15827
103 5GWT SIN 2.15827
104 4FC7 NAP 2.16606
105 4FC7 COA 2.16606
106 5DF1 58X 2.17391
107 5DF1 NAP 2.17391
108 1KYZ SAH 2.19178
109 1KYZ FER 2.19178
110 4ONQ SFG 2.2409
111 5CUQ NSC 2.24719
112 2UYQ SAM 2.25806
113 2ATJ BHO 2.27273
114 5GT9 NAP 2.28137
115 1OC2 NAD 2.29885
116 1OC2 TDX 2.29885
117 5OJI ISN 2.30769
118 5OJI NAP 2.30769
119 3OFK SAH 2.31481
120 3G2O SAM 2.34114
121 4B63 NAP 2.34742
122 4B63 ORN 2.34742
123 4B63 FAD 2.34742
124 5JAQ NAI 2.34742
125 6H3O FAD 2.34742
126 2R4J FAD 2.34742
127 2R4J 13P 2.34742
128 2EJU SAH 2.38095
129 1PVN MZP 2.39362
130 6BWL NAD 2.43902
131 3TKY SAH 2.44565
132 1I8T FAD 2.45232
133 3FPZ AHZ 2.45399
134 1PR9 NAP 2.45902
135 3D3W NAP 2.45902
136 2DPM SAM 2.46479
137 3ABI NAD 2.46575
138 4PIO SAH 2.47678
139 4PIO AVI 2.47678
140 3ZV6 NAD 2.4911
141 3ZV6 4HB 2.4911
142 1NW5 SAM 2.50784
143 3CTY FAD 2.50784
144 1XG5 NAP 2.50896
145 5KVA SAM 2.51799
146 1GY8 NAD 2.51889
147 2B4Q NAP 2.53623
148 1V59 NAD 2.58216
149 1V59 FAD 2.58216
150 4D42 NAP 2.58216
151 4D42 W0I 2.58216
152 2ZXI FAD 2.58216
153 5WXU FLC 2.58216
154 1VL8 NAP 2.62172
155 6EL3 NAP 2.62467
156 1ZEM NAD 2.67176
157 3TLJ SAH 2.68097
158 5XNC MTA 2.69542
159 1Q0S SAH 2.7027
160 4MO2 FDA 2.71739
161 4MO2 FAD 2.71739
162 6BQ6 TER 2.71903
163 3O03 NAP 2.74914
164 4XUC 43G 2.75229
165 4XUC SAM 2.75229
166 4FN4 NAD 2.75591
167 3FRH SAH 2.7668
168 1KPH SAH 2.78746
169 1KPG SAH 2.78746
170 2ZFU SAH 2.7907
171 3G89 SAM 2.81124
172 5WP4 SAH 2.8169
173 3M6W SAM 2.8169
174 3O7W SAM 2.8169
175 4D04 NAP 2.8169
176 4D04 FAD 2.8169
177 5J5Z FAD 2.8169
178 1RP0 AHZ 2.8169
179 3UOY NAP 2.8169
180 3UOY FAD 2.8169
181 4AP3 FAD 2.8169
182 4AP3 NAP 2.8169
183 2JJQ SAH 2.82353
184 1SVK ALF GDP 2.83286
185 3DMH SAM 2.88714
186 3DMH GMP 2.88714
187 3EVF GTA 2.88809
188 3EVF SAH 2.88809
189 1WY7 SAH 2.89855
190 4YMH SAH 2.91667
191 3BXO SAM 2.92887
192 4NTD FAD 2.94118
193 5UFN SAH 2.94118
194 1XCL SAH 2.97872
195 1IY8 NAD 2.99625
196 1SQF SAM 3.05164
197 5DNK SAH 3.05164
198 1ZK7 FAD 3.05164
199 1ZGA SAH 3.05164
200 4JDR FAD 3.05164
201 1H82 FAD 3.05164
202 1H82 GZZ 3.05164
203 3RKR NAP 3.05344
204 5EPO NAP 3.05344
205 5Z75 NAD 3.0581
206 4EUE NAI 3.11005
207 4BLW SAH 3.11419
208 4YAG NAI 3.11419
209 4BLW AMP 3.11419
210 5K4W THR 3.11526
211 5K4W NAI 3.11526
212 1GEG NAD 3.125
213 4HA6 FAD 3.14961
214 6GAR FAD 3.15186
215 1BH2 GSP 3.1746
216 5I39 FAD 3.18627
217 5TWB FAD 3.19767
218 5THY SAH 3.20988
219 5THZ SAH 3.20988
220 1I9G SAM 3.21429
221 1BDB NAD 3.2491
222 2RH4 EMO 3.2491
223 5KOK SAH 3.27456
224 5KOK R9T 3.27456
225 5KOK S9T 3.27456
226 1IM8 SAI 3.27869
227 3E7W AMP 3.28639
228 2Z3Y F2N 3.28639
229 5VN0 FAD 3.28639
230 5VN0 NAI 3.28639
231 4Z24 FAD 3.28639
232 4YNU FAD 3.28639
233 4YNU LGC 3.28639
234 2O07 SPD 3.28947
235 2O07 MTA 3.28947
236 1AE1 NAP 3.2967
237 4USR FAD 3.3241
238 5K0A FAD 3.33333
239 4X9M FAD 3.34928
240 5GM1 SAH 3.367
241 1JQ3 AAT 3.37838
242 5DLY SAH 3.38346
243 5DLY 5D7 3.38346
244 4NEC SAH 3.40909
245 3LST SAH 3.44828
246 6ECU SAH 3.48101
247 1TPY SAH 3.48432
248 6ECW SAH 3.49206
249 1P1C SAH 3.51759
250 5U19 827 3.51906
251 5U19 SAH 3.51906
252 4C4A SAH 3.52113
253 4REP FAD 3.52113
254 4RSL FAD 3.52113
255 5YRM BGC GLC 3.52113
256 4LHD GLY 3.52113
257 3GDN FAD 3.52113
258 3GDN HBX 3.52113
259 4AT0 FAD 3.52113
260 5TTJ FAD 3.52113
261 2YG3 FAD 3.53201
262 1XTP SAI 3.54331
263 3U4C NDP 3.55872
264 2V6G NAP 3.57143
265 1RJD SAM 3.59281
266 5ME4 HP4 3.64964
267 1B4P GPS 3.68664
268 4TQG NDP 3.71517
269 3GDH SAH 3.73444
270 5E1M SAH 3.73444
271 5E1M PRO PRO LYS ARG ILE ALA 3.73444
272 4KRG SAH 3.75587
273 5JJR SAH 3.75587
274 3LAD FAD 3.75587
275 4X7Y SAH 3.75587
276 2FR1 NDP 3.75587
277 5WKC FAD 3.75587
278 1T9D P25 3.75587
279 1T9D 1MM 3.75587
280 1T9D PYD 3.75587
281 1T9D FAD 3.75587
282 1H5Q NAP 3.77358
283 1G55 SAH 3.79009
284 3C3Y SAH 3.79747
285 5W7M SAH 3.84615
286 5LOG SAH 3.86266
287 4E70 N7I 3.86598
288 2PWY SAH 3.87597
289 1KEW NAD 3.87812
290 3GCZ SAM 3.90071
291 6GAS FAD 3.92749
292 6C8R SAH 3.95778
293 6C8R EQV 3.95778
294 1I1N SAH 3.9823
295 2WA2 SAM 3.98551
296 4D79 ATP 3.98551
297 3PT9 SAH 3.99061
298 2HQM FAD 3.99061
299 3HDY FDA 4.03023
300 3HDY GDU 4.03023
301 3HDY FAD 4.03023
302 4CQM NAP 4.09836
303 6C5B SAH 4.10557
304 2D3Y DU 4.10959
305 1ELI PYC 4.11311
306 1UAY ADN 4.13223
307 2XYQ SAH 4.13793
308 2YX1 SFG 4.16667
309 2DTX BMA 4.16667
310 4KVG GTP 4.16667
311 5X62 SAH 4.18719
312 1GUA GNP 4.19162
313 4HDO GNP 4.19162
314 5KMS NAD 4.19753
315 3WYF GTP 4.20168
316 1UWK NAD 4.22535
317 1UWK URO 4.22535
318 4D7E FAD 4.22535
319 3SQP FAD 4.22535
320 1WA5 GTP 4.22535
321 2NVK FAD 4.22535
322 4DSG FAD 4.22535
323 4DSG UDP 4.22535
324 1G0N PHH 4.24028
325 1G0N NDP 4.24028
326 3LCC SAH 4.25532
327 2WK1 SAH 4.25532
328 1FP2 SAH 4.26136
329 1FP2 HMO 4.26136
330 1YXM ADE 4.29043
331 2JK0 ASP 4.30769
332 6ECT SAM 4.36137
333 4O0L NDP 4.36364
334 4M38 SAH 4.37318
335 4M37 SAH 4.37318
336 1KYQ NAD 4.37956
337 4J56 FAD 4.38596
338 5BVA FAD 4.40098
339 3FIU POP 4.41767
340 5N5D SAM 4.42478
341 1EJ0 SAM 4.44444
342 5WGR FAD 4.46009
343 5T2U NAP 4.46009
344 2RGO FAD 4.46009
345 1VQW FAD 4.46009
346 2GV8 FAD 4.46009
347 2GVC FAD 4.46009
348 3AXB FAD 4.46009
349 3AXB PRO 4.46009
350 3T7S SAM 4.47761
351 2GDZ NAD 4.49438
352 4POO SAM 4.5
353 6DUB SAH 4.5045
354 6GKV SAH 4.5584
355 3E3U NVC 4.56853
356 2P41 SAH 4.59016
357 5N53 8NB 4.61538
358 4OBW SAM 4.66926
359 1JG3 ADN 4.68085
360 5WP5 SAH 4.69484
361 1G60 SAM 4.69484
362 1Y8Q ATP 4.69484
363 5HSA FAS 4.69484
364 6DEN G8A 4.69484
365 6DEN FAD 4.69484
366 6DEN TP9 4.69484
367 2ZIF SAM 4.7138
368 1XHL NDP 4.7138
369 3KIF GDL 4.71698
370 2WSB NAD 4.72441
371 3SJK LYS PRO VAL LEU ARG THR ALA 4.73684
372 5EEH SAH 4.78723
373 5EEH P9P 4.78723
374 2Q1W NAD 4.8048
375 3I53 SAH 4.81928
376 4UCI SAM 4.81928
377 4Y30 SAH 4.8433
378 4Y30 49L 4.8433
379 3GEG NAD 4.8583
380 3VYW SAM 4.87013
381 3GU3 SAH 4.92958
382 1NV8 SAM 4.92958
383 1NV8 MEQ 4.92958
384 4AZW SAM 4.92958
385 1Q9I FAD 4.92958
386 1Q9I TEO 4.92958
387 1IBR GNP 4.92958
388 5KOX RFP 4.92958
389 5KOX FAD 4.92958
390 5OC1 FAD 4.92958
391 3CW9 AMP 4.92958
392 1ZCB GDP 4.97238
393 3HVJ 705 4.97738
394 1N2X SAM 4.98339
395 3A25 SAM 4.98339
396 3NYC IAR 4.98688
397 3NYC FAD 4.98688
398 2AE2 PTO 5
399 2AE2 NAP 5
400 4DCM SAM 5.06667
401 1J71 THR ILE THR SER 5.08982
402 1FP1 SAH 5.10753
403 5GVR LMR 5.12821
404 3ICT FAD 5.16432
405 4MIG G3F 5.16432
406 2A8X FAD 5.16432
407 4BV6 FAD 5.16432
408 3ICS FAD 5.16432
409 4M52 FAD 5.16432
410 3ICR FAD 5.16432
411 3ICT ADP 5.16432
412 2QPU QPU 5.18518
413 3P9C SAH 5.21978
414 2EWM NAD 5.22088
415 1L1E SAH 5.22648
416 3M1I GTP 5.2356
417 5BW4 SAM 5.24345
418 5YEC ATP 5.29412
419 2PK3 A2R 5.29595
420 4KIB SAH 5.32213
421 3EGI ADP 5.33981
422 3DUW SAH 5.38117
423 6FDF SAH 5.38922
424 4RVG TYD 5.39906
425 4RVG SAM 5.39906
426 2JHP SAH 5.39906
427 4RPL FAD 5.39906
428 4RPL 3UC 5.39906
429 3GD4 NAD 5.39906
430 3GD4 FAD 5.39906
431 5EB4 FAD 5.39906
432 5GSN FAD 5.39906
433 5GSN NAP 5.39906
434 3CX8 GSP 5.41872
435 4FZV SAM 5.43933
436 1ORR NAD 5.4755
437 1SQL GUN 5.47945
438 5JGL SAM 5.53633
439 4RDH AMP 5.55556
440 4RDI ATP 5.55556
441 2HMT NAI 5.55556
442 4YUW 4JU 5.59211
443 4YUW S4M 5.59211
444 3Q87 SAM 5.6
445 2GN4 UD1 5.6338
446 2GN4 NDP 5.6338
447 5T67 JHZ 5.6338
448 5T67 SAH 5.6338
449 2XVE FAD 5.6338
450 1GPE FAD 5.6338
451 2XVF FAD 5.6338
452 2QA1 FAD 5.6338
453 1YBH FAD 5.6338
454 3GJX GTP 5.6338
455 2Q28 ADP 5.6338
456 4M73 SAH 5.63798
457 4M73 M72 5.63798
458 2ODE ALF GDP 5.67376
459 2VDV SAM 5.69106
460 3FPF TNA 5.7047
461 3FPF MTA 5.7047
462 5F2K SAH 5.70652
463 5F2K OCA 5.70652
464 2EFJ SAH 5.72917
465 2BD0 NAP 5.7377
466 5E9W SAH 5.76923
467 5E8J SAH 5.76923
468 6B92 SAH 5.78231
469 4CS9 AMP 5.82011
470 6AU6 GDP 5.83554
471 2Q7V FAD 5.84615
472 4KRI SAH 5.86854
473 1D4D FAD 5.86854
474 1QO8 FAD 5.86854
475 5TS5 FAD 5.86854
476 2WET FAD 5.86854
477 3RAB GNP 5.91716
478 1F3L SAH 5.919
479 3GWZ SAH 5.96206
480 3GXO SAH 5.96206
481 1RPN NDP 5.97015
482 5N0J FAD 5.98291
483 5BSZ SAH 6
484 1G8K MGD 6.01504
485 3X0D SAH 6.10329
486 1REO FAD 6.10329
487 2IVD FAD 6.10329
488 5O42 NAD 6.20438
489 5O42 BGC 6.20438
490 5O42 9JW 6.20438
491 4LWP SAH 6.25
492 3FUU ADN 6.27306
493 3HNB 768 6.28931
494 3QWI CUE 6.2963
495 3QWI NAP 6.2963
496 2NXE SAM 6.29921
497 3FSY SCA 6.3253
498 5E72 SAM 6.33803
499 3AYI FAD 6.33803
500 3AYI HCI 6.33803
501 5OCG GNP 6.34921
502 4DMG SAM 6.36132
503 1QZZ SAM 6.41711
504 3SBD GNP 6.41711
505 3JWH SAH 6.45161
506 1QAN SAH 6.55738
507 3NDJ JHZ 6.57277
508 3NDJ SAH 6.57277
509 3OID NDP 6.58915
510 6ARJ BW4 6.59026
511 5DX8 SFG 6.59026
512 6ARJ SAH 6.59026
513 5DXA SFG 6.59026
514 5DX1 SFG 6.59026
515 5DX0 SFG 6.59026
516 5DWQ SFG 6.59026
517 2FK8 SAM 6.60377
518 5LFV SIA GAL NAG 6.62461
519 1ZQ9 SAM 6.66667
520 1XDS SAM 6.68449
521 2PX8 SAH 6.69145
522 6GFK SAH 6.77291
523 4NBU NAI 6.8
524 1OIX GDP 6.80628
525 2JB2 FAD 6.80751
526 2JB2 PHE 6.80751
527 4J1Q NDP 6.80751
528 5FUB SAH 6.82493
529 5JE0 SAH 6.88259
530 5JE0 AZ8 6.88259
531 4Y9D NAI 6.88525
532 3CBG SAH 6.89655
533 5F8F SFG 6.89655
534 6FA4 GNP 6.93642
535 4IWN GEK 6.9869
536 5UWJ GNP 6.99301
537 5DIF GNP 6.99301
538 5UWI GNP 6.99301
539 5DI9 GNP 6.99301
540 6CIT GNP 6.99301
541 5UWP GNP 6.99301
542 5UWR GNP 6.99301
543 5UWW GNP 6.99301
544 5UWU GNP 6.99301
545 5DHF GNP 6.99301
546 5UWQ GNP 6.99301
547 5UWO GNP 6.99301
548 5UWS GNP 6.99301
549 5UWH GNP 6.99301
550 5UWT GNP 6.99301
551 5WDR GNP 7.01754
552 4XQC NAD 7.04225
553 1NAA ABL 7.04225
554 1NAA 6FA 7.04225
555 5W7K SAH 7.05128
556 4ITU 1HS 7.0632
557 4ITU NAI 7.0632
558 5O2T GSP 7.10059
559 4HAT GNP 7.14286
560 5SZH GNP 7.18954
561 3A27 SAM 7.35294
562 1UDB UFG 7.39645
563 1UDB NAD 7.39645
564 4C3Y FAD 7.51174
565 4C3Y ANB 7.51174
566 2HNK SAH 7.53138
567 2WPB ZZI 7.56579
568 4BWL MN9 7.56579
569 1O97 FAD 7.57576
570 1O97 AMP 7.57576
571 6CA4 MLI 7.6
572 4K81 GTP 7.60234
573 4JNA FAD 7.64706
574 1YZQ GNP 7.64706
575 1R6D NAD 7.71513
576 1R6D DAU 7.71513
577 6D5H GNP 7.78443
578 6D5M GNP 7.78443
579 6D5E GNP 7.78443
580 6D5V GNP 7.78443
581 6D59 GNP 7.78443
582 6D5G GNP 7.78443
583 6BVJ GNP 7.78443
584 6D56 GNP 7.78443
585 6BVL GNP 7.78443
586 6BVM GNP 7.78443
587 6D5L GNP 7.78443
588 6BVI GNP 7.78443
589 6D55 GNP 7.78443
590 6BVK GNP 7.78443
591 6D5J GNP 7.78443
592 5YW5 ADE 7.82123
593 1NVV GNP 7.83133
594 2UZI GTP 7.83133
595 1IK4 PGH 7.89474
596 5FEU NAP 7.90378
597 1JBU BEN 7.93651
598 1ZC3 GNP 7.9646
599 2IID FAD 7.98122
600 2IID PHE 7.98122
601 3EVG SAH 8
602 3NKV GNP 8
603 4ZRN NAD 8.01282
604 4ZRN UPG 8.01282
605 2GAG NAD 8.09524
606 3GRU AMP 8.13559
607 5ERG SAM 8.19672
608 5BJX NAD 8.19672
609 5BJX UDP 8.19672
610 3MQ2 SAH 8.25688
611 1TZJ A3B 8.28402
612 1VE3 SAM 8.37004
613 2PXX SAH 8.37209
614 4FGC PQ0 8.48485
615 2A14 SAH 8.74525
616 3MAG SAH 8.79479
617 5FWA J7C 8.92019
618 3CH6 NAP 8.92019
619 3CH6 311 8.92019
620 2VVM FAD 8.92019
621 2VVL FAD 8.92019
622 2CDU FAD 8.92019
623 3TKA SAM 8.93372
624 5FFF NAP 8.94942
625 5FFF 5XC 8.94942
626 1WS5 MMA 9.02256
627 1UGY GLA BGC 9.02256
628 1WS4 AMG 9.02256
629 1UGW GAL 9.02256
630 1WS4 GYP 9.02256
631 1UGY GLA GLC 9.02256
632 1JAC AMG 9.02256
633 1Z3C SA8 9.0604
634 3MCT SAH 9.09091
635 4YJK URA 9.12698
636 5YJI SAH 9.15493
637 5YJI 8WO 9.15493
638 5YJF SAH 9.15493
639 5YJF 8WO 9.15493
640 5YRG BGC GLC 9.15493
641 5YRJ BGC GLC 9.15493
642 4CNK FAD 9.20716
643 2XVM SAH 9.54774
644 1U7T TDT 9.57854
645 1E3W NAD 9.57854
646 4PNE SAH 9.60265
647 3LCV SAM 9.60854
648 2YY7 NAD 9.61539
649 1E6W NAD 9.61539
650 3LZW FAD 9.63855
651 3LZW NAP 9.63855
652 1XKQ NDP 9.64286
653 1VG8 GNP 9.66184
654 2PZM NAD 9.69697
655 2PZM UDP 9.69697
656 5K7U SAM 9.77778
657 1DL5 SAH 9.77918
658 2GNK ATP 9.82143
659 1WG8 SAM 9.82456
660 3H2B SAH 9.85222
661 6IS0 SAH 9.85915
662 1CS4 GSP 9.90566
663 5ICE 2H4 9.94318
664 5ICE SAH 9.94318
665 1LSS NAD 10
666 3FZG SAM 10
667 4EAX S12 10
668 3DXY SAM 10.0917
669 3AD8 NAD 10.101
670 3A4T SFG 10.219
671 5ZW3 SAH 10.2222
672 2HRL SIA GAL SIA BGC NGA CEQ 10.2362
673 1YZN GNP 10.2703
674 3TNF GNP 10.3448
675 3RNM FAD 10.3448
676 4LHW GNP 10.3448
677 5IL1 SAM 10.3774
678 3S1S SAH 10.5634
679 4L2I FAD 10.6464
680 1O5I NAD 10.8434
681 4R6W PC 10.8527
682 4R6W SAH 10.8527
683 1E6E FAD 10.9375
684 1NME 159 10.9589
685 3P2E SAH 11.1111
686 1EFV FAD 11.1111
687 1EFV AMP 11.1111
688 5FA5 MTA 11.2676
689 4GQB 0XU 11.2676
690 4X60 SFG 11.2676
691 4X60 3XV 11.2676
692 5Z2M GTP 11.3636
693 3VC1 SAH 11.5385
694 3VC1 GST 11.5385
695 2C5L GTP 11.9658
696 1GET FAD 11.9718
697 1GET NAP 11.9718
698 3QFA FAD 12.069
699 4A6D SAM 12.1813
700 4II2 ATP 12.2699
701 6D6Y SAH 12.9108
702 5XLX SAH 13.1206
703 2OBF SAH 13.1488
704 2OBF F83 13.1488
705 1FQK GDP 13.2308
706 1TAD GDP 13.2716
707 1TAD ALF 13.2716
708 2Y8E GNP 13.4078
709 3LU1 NAD 13.4615
710 1EDO NAP 13.5246
711 2AOT SAH 13.6986
712 1JQD SAH 13.6986
713 1JQD HSM 13.6986
714 1UAD GNP 13.7143
715 1SB8 UD2 13.9205
716 1SB8 NAD 13.9205
717 3LKZ SFG 14.3302
718 5C2N NAG 14.5833
719 5DM1 SAH 14.6067
720 5DM1 5D7 14.6067
721 5LWY OLB 14.9533
722 5LEF GTP 15.1515
723 2F5Z FAD 15.625
724 5ULP KB1 16.0448
725 4YSX FAD 16.6667
726 3BC1 GNP 16.9492
727 3WYG GTP 17.1053
728 3H8V ATP 17.4658
729 2BZG SAH 17.6724
730 3VPB GLU 17.8571
731 5L95 AMP 18.2796
732 4QTU SAM 18.5185
733 3MB5 SAM 18.8235
734 5M58 SAH 19.1304
735 6F5Z SAH 19.6721
736 3PFG TLO 20.5323
737 3PFG SAM 20.5323
738 3BGD SAH 20.7692
739 3BGD PM6 20.7692
740 5MGZ SAH 22.8814
741 1GRN AF3 26.178
742 2NGR AF3 26.178
743 2FFQ GSP 28.0702
744 3DDC GNP 29.5181
745 1NBU PH2 30.2521
746 1L3I SAH 36.4583
747 5FA8 SAM 37.8882
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