Receptor
PDB id Resolution Class Description Source Keywords
3PXZ 1.7 Å EC: 2.7.11.22 CDK2 TERNARY COMPLEX WITH JWS648 AND ANS HOMO SAPIENS PROTEIN KINASE CDK2 ALLOSTERIC LIGAND ANS TRANSFERASE-TRINHIBITOR COMPLEX
Ref.: DISCOVERY OF A POTENTIAL ALLOSTERIC LIGAND BINDING CDK2. ACS CHEM.BIOL. V. 6 492 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
2AN A:299;
A:300;
Valid;
Valid;
none;
none;
Kd = 37 uM
299.344 C16 H13 N O3 S c1ccc...
JWS A:301;
Valid;
none;
ic50 = 5.9 uM
233.227 C10 H11 N5 O2 COc1c...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2XMY 1.9 Å EC: 2.7.11.22 DISCOVERY AND CHARACTERISATION OF 2-ANILINO-4-(THIAZOL-5-YL) PYRIMIDINE TRANSCRIPTIONAL CDK INHIBITORS AS ANTICANCER A GENTS HOMO SAPIENS CELL CYCLE TRANSFERASE CDK9 INHIBITOR
Ref.: DISCOVERY AND CHARACTERISATION OF 2-ANILINO-4-( THIAZOL-5-YL)PYRIMIDINE TRANSCRIPTIONAL CDK INHIBIT ANTICANCER AGENTS CHEM.BIOL. V. 17 1111 2010
Members (169)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 17 families.
1 3PXQ Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
2 2R3N ic50 = 70 nM SCZ C21 H19 N5 c1ccc(cc1)....
3 1H0V - UN4 C10 H12 N6 O2 c1[nH]c2c(....
4 4NJ3 Kd = 0.3 uM 2KD C27 H21 Cl N2 O6 COC(=O)[C@....
5 1JSV - U55 C10 H11 N5 O2 S c1cc(ccc1N....
6 1OIQ ic50 = 2.9 uM HDU C14 H13 N5 O Cc1c(n2ccc....
7 2W17 ic50 = 0.002 uM I19 C24 H30 F N7 O Cc1ncc(n1C....
8 2VTP ic50 = 0.003 uM LZ9 C17 H11 F3 N4 O2 c1cc(c(c(c....
9 1JVP ic50 = 1.6 uM LIG C15 H11 N3 c1ccc-2c(c....
10 1FVT - 106 C14 H11 Br N4 O3 S c1cc(ccc1N....
11 4KD1 - 1QK C21 H29 N6 O2 CCc1cnn2c1....
12 3LE6 ic50 = 0.035 uM 2BZ C17 H10 Cl N5 O2 Cc1c-2nc(c....
13 2VTI ic50 = 0.66 uM LZ3 C14 H12 N4 O3 S c1ccc2c(c1....
14 3LFS Ki = 2.5 uM A07 C17 H16 Cl N3 O CCCC(=O)Nc....
15 1PXI - CK1 C8 H5 Cl2 N3 S c1cnc(nc1c....
16 4LYN - 1YG C20 H23 N3 O2 S2 C[C@@H](c1....
17 1YKR ic50 = 0.56 uM 628 C20 H14 Cl2 N4 O3 S c1cc(c(c(c....
18 1PXN Ki = 0.07 uM CK6 C15 H15 N5 O S Cc1c(sc(n1....
19 2R3J ic50 = 10 nM SCJ C18 H14 Br N5 c1ccc(cc1)....
20 6Q3F - HEW C5 H5 Br N2 c1cnc(cc1B....
21 3IG7 ic50 = 9 nM EFP C18 H22 N4 O3 CC(=O)NC1C....
22 2VTS ic50 = 0.03 uM LZC C16 H23 N7 CC(C)Nc1cc....
23 1P2A ic50 = 12 nM 5BN C17 H15 F N4 O c1cc([nH]c....
24 2BHE ic50 = 1 uM BRY C16 H9 Br N2 O2 c1ccc2c(c1....
25 3UNK ic50 = 15 uM 0BY C17 H13 Cl N4 O2 c1ccc(c(c1....
26 2VTQ ic50 = 0.14 uM LZA C16 H17 F2 N5 O2 c1cc(c(c(c....
27 2C68 ic50 = 1.8 uM CT6 C18 H15 Br N5 c1cc(cc(c1....
28 3TIZ - 3TI C17 H13 N O2 c1ccc2c(c1....
29 3PXY ic50 = 5.9 uM JWS C10 H11 N5 O2 COc1ccc(c(....
30 2R3M ic50 = 10 nM SCX C19 H17 F2 N7 CCc1cnn2c1....
31 5JQ5 Kd = 2341 nM I74 C22 H30 N6 O CC(C)c1cnn....
32 2C6O - 4SP C18 H22 N6 O3 S c1cc(ccc1N....
33 1V1K ic50 = 35 uM 3FP C22 H23 F4 N5 O2 CN(C)C[C@H....
34 2VTJ ic50 = 1.9 uM LZ4 C10 H9 Cl N4 O2 S c1cc(ccc1N....
35 3EZV - EZV C25 H25 N7 CN1CCN(CC1....
36 3PXZ Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
37 1W0X - OLO C15 H18 N6 O Cn1cnc2c1n....
38 2XMY Ki = 0.11 nM CDK C18 H21 N5 O4 S2 CC1=C(SC(=....
39 2UZO ic50 = 27 uM C62 C14 H10 N2 O5 S2 c1cc(ccc1c....
40 1KE7 ic50 = 8.9 nM LS3 C20 H15 N3 O4 S c1cc2c(cc1....
41 1DM2 - HMD C11 H10 Br N5 O2 C1CNC(=O)C....
42 1DI8 ic50 = 1 uM DTQ C16 H15 N3 O3 COc1cc2c(c....
43 5JQ8 - I73 C22 H30 N6 O CC(C)c1cnn....
44 6Q4H - HGH C13 H11 N5 O3 c1cc(cc(c1....
45 1GIJ - 2PU C19 H22 N6 O2 c1cc2c(c(c....
46 2R3P ic50 = 900 nM 3SC C19 H12 Cl2 N6 S c1cc(c(c(c....
47 1KE8 ic50 = 1000 nM LS4 C18 H14 N4 O3 S2 c1ccc2c(c1....
48 2C6I ic50 = 11 uM DT1 C18 H22 N6 O3 S c1cc(ccc1N....
49 1PXP Ki = 0.22 uM CK8 C17 H19 N5 S Cc1c(sc(n1....
50 6Q3C - BYZ C3 H3 Br N2 c1c(cn[nH]....
51 2UZN ic50 = 0.03 uM C96 C15 H13 N3 O4 S2 [H]/N=C/1N....
52 2B55 ic50 = 96 nM D31 C24 H31 N5 O2 c1cc-2c(c(....
53 5K4J - 6QB C21 H18 Cl F N6 O2 Cn1c(ccn1)....
54 3PJ8 - 404 C19 H26 N6 O CC[C@H](CO....
55 3LFQ - A28 C17 H15 F2 N3 O CCCC(=O)Nc....
56 2W05 ic50 = 0.001 uM FRT C20 H26 N6 O3 S Cc1ncc(n1C....
57 2XNB Ki = 149 nM Y8L C19 H22 N6 O S CC1=C(SC(=....
58 1HCK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
59 5IEX - 6AF C17 H21 Br N4 O3 S C[C@H]([C@....
60 2R3H ic50 = 20000 nM SCE C13 H13 N5 Cc1cnc2n1c....
61 3LFN ic50 = 3160 nM A27 C23 H21 N3 O2 CCCC(=O)Nc....
62 3PY1 Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
63 2A4L ic50 = 0.4 uM RRC C19 H26 N6 O CC[C@H](CO....
64 1Y8Y ic50 = 2 uM CT7 C13 H11 Cl N4 O2 S CS(=O)(=O)....
65 6GUH Kd = 26 nM FB8 C18 H21 N5 O2 S Cc1ncc(n1C....
66 1OIR ic50 = 0.032 uM HDY C23 H26 N6 O2 Cc1c(n2ccc....
67 1PXJ - CK2 C9 H10 N4 S Cc1c(sc(n1....
68 2VTO ic50 = 0.14 uM LZ8 C17 H13 F N4 O2 c1ccc(cc1)....
69 2BTR ic50 = 95 nM U73 C13 H15 N3 O S CC(C)C1=CN....
70 6Q4K - HHW C16 H12 Cl N O3 c1cc(cc(c1....
71 2VTA ic50 = 185 uM LZ1 C7 H6 N2 c1ccc2c(c1....
72 3EZR - EZR C26 H27 N7 O CN1CCN(CC1....
73 3ULI ic50 = 0.07 uM 1N3 C21 H25 Br N6 O2 COc1ccc(cc....
74 2DS1 ic50 = 3.4 nM 1CD C22 H21 N5 O3 C[C@@H]1C[....
75 5FP5 - 1Y6 C7 H5 F O2 c1cc(ccc1C....
76 2VTH ic50 = 120 uM LZ2 C10 H9 N O3 S c1cc2c(ccc....
77 1KE5 ic50 = 560 nM LS1 C16 H15 N3 O3 S CNS(=O)(=O....
78 3FZ1 - B98 C13 H15 N3 O2 S COc1ccc2c(....
79 1WCC ic50 = 350 uM CIG C4 H4 Cl N3 c1c(nc(cn1....
80 1PXO Ki = 2 nM CK7 C14 H12 N6 O2 S Cc1c(sc(n1....
81 1H00 ic50 = 38 uM FAP C21 H23 F2 N5 O2 CN(C)C[C@@....
82 2R3R - 6SC C18 H14 Br N5 c1ccc(cc1)....
83 1B39 Kd = 0.12 uM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
84 6Q4C - HH8 C8 H5 Br N2 c1cc2c(ccn....
85 3PXF Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
86 3TI1 - B49 C22 H27 F N4 O2 CCN(CC)CCN....
87 2R3G ic50 = 800 nM SC9 C18 H14 F N5 c1ccc(c(c1....
88 2C69 ic50 = 26 uM CT8 C17 H14 Br N6 c1cc(cc(c1....
89 2VTM ic50 ~ 1 mM LZM C7 H4 N4 c1cnc2c(cn....
90 4ERW - STU C28 H26 N4 O3 C[C@@]12[C....
91 1E1V Ki = 12 uM CMG C12 H17 N5 O c1[nH]c2c(....
92 2VV9 ic50 = 0.017 uM IM9 C23 H29 N7 O2 Cc1ncc(n1C....
93 5IEV - R0N C18 H23 F3 N4 O3 S C[C@H]([C@....
94 6Q48 - HHQ C5 H4 I N O C1C(=CC=NC....
95 4D1X - ESJ C11 H8 N2 O3 S2 c1cc2c(cc1....
96 5MHQ - 8QT C19 H27 N7 O CC[C@@H]([....
97 2BTS ic50 = 20 nM U32 C12 H15 N3 O2 S2 CC(C)c1cnc....
98 6Q4D - HHT C9 H9 Br O3 COc1cc(ccc....
99 1URW ic50 < 0.003 uM I1P C21 H24 N8 O2 S CN(C)CCCNS....
100 5FP6 - MFZ C11 H7 Cl2 N O c1cc(c2c(c....
101 1CKP - PVB C20 H25 Cl N6 O3 CC(C)[C@H]....
102 1KE6 ic50 = 5.7 nM LS2 C17 H15 N5 O3 S2 CNS(=O)(=O....
103 2C6K ic50 = 0.73 uM DT2 C17 H21 N7 O2 S c1cc(ccc1N....
104 6Q4F - 26D C5 H7 N3 c1cc(nc(c1....
105 2R3Q - 5SC C19 H16 Br N5 O Cc1ccccc1c....
106 1OIT ic50 < 0.003 uM HDT C17 H14 N6 O2 S c1ccn2c(c1....
107 3NS9 ic50 = 0.003 uM NS9 C20 H27 N5 O3 CC(C)c1cnn....
108 6Q4I - HGK C13 H11 N O4 c1cc(ccc1C....
109 1H01 ic50 = 22 uM FAL C21 H23 Cl2 N5 O2 CN(C)C[C@H....
110 2EXM - ZIP C10 H13 N5 CC(=CCNc1c....
111 4BGH ic50 = 4 nM 3I6 C13 H16 Br N5 O3 S C[C@H](CO)....
112 2R3F ic50 = 500 nM SC8 C18 H13 Cl2 N5 c1cc(c(c(c....
113 1GII - 1PU C17 H16 N4 O2 c1ccnc(c1)....
114 6Q4B - HHN C4 H3 Br N2 c1c(cncn1)....
115 2R64 ic50 = 0.03 uM 740 C23 H27 N5 O3 S c1cc(ccc1C....
116 5A14 - LQ5 C24 H26 F3 N7 O2 CN1CCN(CC1....
117 2C6L ic50 = 0.27 uM DT4 C17 H22 N8 O2 S c1cc(ccc1N....
118 2W06 - FRV C18 H20 N6 O2 S Cc1ncc(n1C....
119 4EZ7 - STU C28 H26 N4 O3 C[C@@]12[C....
120 6Q4J - HHB C12 H11 N3 O2 c1cc(cc(c1....
121 5D1J ic50 = 48 nM 56H C17 H24 N4 O2 S2 CC(C)(C)c1....
122 5IEY - 6AE C14 H19 N5 O3 S C[C@H]([C@....
123 2VTT ic50 = 0.044 uM LZD C16 H17 F2 N5 O2 c1cc(c(c(c....
124 2VU3 ic50 = 0.047 uM LZE C16 H17 Cl2 N5 O2 c1cc(c(c(c....
125 2B54 - D05 C20 H15 Cl3 N4 O3 CCc1c2c(n(....
126 1GZ8 - MBP C10 H13 N5 O2 CC(C)C(=O)....
127 3PY0 ic50 = 0.13 uM SU9 C13 H11 N3 O2 COc1ccc2c(....
128 2VTR ic50 = 1.5 uM LZB C10 H10 Cl N5 CC(C)Nc1cc....
129 1E1X Ki = 1.3 uM NW1 C11 H17 N5 O2 C1CCC(CC1)....
130 3UNJ ic50 = 11 uM 0BX C17 H14 N4 O2 c1ccc(cc1)....
131 2A0C - CK9 C19 H26 N6 O2 CC[C@H](CO....
132 3TIY - TIY C11 H8 O5 c1c2c(c(c(....
133 2R3I ic50 = 1000 nM SCF C18 H14 F N5 c1ccc(c(c1....
134 1VYZ ic50 = 290 nM N5B C13 H13 N3 O c1ccc(cc1)....
135 3WBL ic50 = 23 uM PDY C20 H26 N6 O CCOc1ccc(c....
136 4RJ3 ic50 = 93 nM 3QS C22 H28 N6 O COC1CCN(CC....
137 2VTN ic50 = 0.85 uM LZ7 C12 H11 F N4 O2 CC(=O)Nc1c....
138 1AQ1 - STU C28 H26 N4 O3 C[C@@]12[C....
139 2C6M ic50 = 0.35 uM DT5 C17 H20 N6 O3 S c1cc(ccc1N....
140 2R3L ic50 = 100 nM SCW C18 H14 Br N5 c1ccc(cc1)....
141 6Q4A - HGW C4 H3 I N2 c1c(cncn1)....
142 1H08 - BYP BWP n/a n/a
143 1B38 Kd = 0.254 uM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
144 2B52 ic50 = 8 nM D42 C21 H23 N7 O2 S Cc1c(sc(n1....
145 1PXL - CK4 C16 H13 F3 N4 S Cc1c(sc(n1....
146 3S2P ic50 = 0.068 uM PMU C17 H22 N4 O3 CC(C)c1cc(....
147 2R3O ic50 = 600 nM 2SC C19 H17 N5 O c1ccc(cc1)....
148 3IGG ic50 = 95 nM EFQ C16 H19 N3 O3 COc1ccc(cc....
149 1R78 ic50 = 3 nM FMD C20 H20 F N3 O4 C[C@H]([C@....
150 2FVD Ki = 0.003 uM LIA C18 H21 F2 N5 O4 S COc1ccc(c(....
151 2VTL ic50 = 97 uM LZ5 C10 H9 N3 O c1ccc(cc1)....
152 1KE9 ic50 = 660 nM LS5 C16 H15 N5 O3 S c1ccc2c(c1....
153 6Q3B - PYZ C3 H3 I N2 c1c(cn[nH]....
154 1PYE Ki = 386 nM PM1 C21 H13 F2 N3 O2 c1ccc(cc1)....
155 6Q49 - HGQ C5 H4 Br N O C1=CNC(=O)....
156 4EZ3 - 0S0 C11 H10 N4 O4 S c1cc(ccc1/....
157 1H07 ic50 = 3 uM MFP C24 H27 Br N6 O2 Cc1ccc(c(c....
158 2B53 ic50 = 0.6 uM D23 C19 H19 F3 N4 CC(C)(C)Nc....
159 6GUK Kd = 715 nM FC8 C19 H24 Cl N7 CCn1cnc2c1....
160 2DUV ic50 = 0.087 uM 371 C19 H17 N O7 S Cc1cc2c(c(....
161 4D1Z - WG8 C13 H10 N2 O3 S c1cc2ccc(n....
162 6Q4E Kd = 350 uM HH5 C5 H4 I N5 c1[nH]c2c(....
163 4ACM Ki = 210 nM 7YG C20 H23 N7 O3 S CN(C)CCNS(....
164 2C5Y ic50 = 0.25 uM MTW C19 H15 N7 O2 c1cc(cc(c1....
165 6Q4G Kd = 50 uM HJK C13 H11 N5 O2 c1cc(cc(c1....
166 2R3K ic50 = 100 nM SCQ C18 H14 Br N5 c1ccc(cc1)....
167 2V0D - C53 C9 H7 N3 O S [H]/N=C1/N....
168 2W1H ic50 = 0.052 uM L0F C17 H13 N5 O c1ccc(cc1)....
169 1Y91 ic50 = 0.059 uM CT9 C23 H33 N7 O2 S CC(C)c1cnn....
70% Homology Family (172)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 14 families.
1 3PXQ Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
2 2R3N ic50 = 70 nM SCZ C21 H19 N5 c1ccc(cc1)....
3 1H0V - UN4 C10 H12 N6 O2 c1[nH]c2c(....
4 4NJ3 Kd = 0.3 uM 2KD C27 H21 Cl N2 O6 COC(=O)[C@....
5 1JSV - U55 C10 H11 N5 O2 S c1cc(ccc1N....
6 1OIQ ic50 = 2.9 uM HDU C14 H13 N5 O Cc1c(n2ccc....
7 2W17 ic50 = 0.002 uM I19 C24 H30 F N7 O Cc1ncc(n1C....
8 2VTP ic50 = 0.003 uM LZ9 C17 H11 F3 N4 O2 c1cc(c(c(c....
9 1JVP ic50 = 1.6 uM LIG C15 H11 N3 c1ccc-2c(c....
10 1FVT - 106 C14 H11 Br N4 O3 S c1cc(ccc1N....
11 4KD1 - 1QK C21 H29 N6 O2 CCc1cnn2c1....
12 3LE6 ic50 = 0.035 uM 2BZ C17 H10 Cl N5 O2 Cc1c-2nc(c....
13 2VTI ic50 = 0.66 uM LZ3 C14 H12 N4 O3 S c1ccc2c(c1....
14 3LFS Ki = 2.5 uM A07 C17 H16 Cl N3 O CCCC(=O)Nc....
15 1PXI - CK1 C8 H5 Cl2 N3 S c1cnc(nc1c....
16 4LYN - 1YG C20 H23 N3 O2 S2 C[C@@H](c1....
17 1YKR ic50 = 0.56 uM 628 C20 H14 Cl2 N4 O3 S c1cc(c(c(c....
18 1PXN Ki = 0.07 uM CK6 C15 H15 N5 O S Cc1c(sc(n1....
19 2R3J ic50 = 10 nM SCJ C18 H14 Br N5 c1ccc(cc1)....
20 6Q3F - HEW C5 H5 Br N2 c1cnc(cc1B....
21 3IG7 ic50 = 9 nM EFP C18 H22 N4 O3 CC(=O)NC1C....
22 2VTS ic50 = 0.03 uM LZC C16 H23 N7 CC(C)Nc1cc....
23 1P2A ic50 = 12 nM 5BN C17 H15 F N4 O c1cc([nH]c....
24 2BHE ic50 = 1 uM BRY C16 H9 Br N2 O2 c1ccc2c(c1....
25 3UNK ic50 = 15 uM 0BY C17 H13 Cl N4 O2 c1ccc(c(c1....
26 2VTQ ic50 = 0.14 uM LZA C16 H17 F2 N5 O2 c1cc(c(c(c....
27 2C68 ic50 = 1.8 uM CT6 C18 H15 Br N5 c1cc(cc(c1....
28 3TIZ - 3TI C17 H13 N O2 c1ccc2c(c1....
29 3PXY ic50 = 5.9 uM JWS C10 H11 N5 O2 COc1ccc(c(....
30 2R3M ic50 = 10 nM SCX C19 H17 F2 N7 CCc1cnn2c1....
31 5JQ5 Kd = 2341 nM I74 C22 H30 N6 O CC(C)c1cnn....
32 2C6O - 4SP C18 H22 N6 O3 S c1cc(ccc1N....
33 1V1K ic50 = 35 uM 3FP C22 H23 F4 N5 O2 CN(C)C[C@H....
34 2VTJ ic50 = 1.9 uM LZ4 C10 H9 Cl N4 O2 S c1cc(ccc1N....
35 3EZV - EZV C25 H25 N7 CN1CCN(CC1....
36 3PXZ Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
37 1W0X - OLO C15 H18 N6 O Cn1cnc2c1n....
38 2XMY Ki = 0.11 nM CDK C18 H21 N5 O4 S2 CC1=C(SC(=....
39 2UZO ic50 = 27 uM C62 C14 H10 N2 O5 S2 c1cc(ccc1c....
40 1KE7 ic50 = 8.9 nM LS3 C20 H15 N3 O4 S c1cc2c(cc1....
41 1DM2 - HMD C11 H10 Br N5 O2 C1CNC(=O)C....
42 1DI8 ic50 = 1 uM DTQ C16 H15 N3 O3 COc1cc2c(c....
43 5JQ8 - I73 C22 H30 N6 O CC(C)c1cnn....
44 6Q4H - HGH C13 H11 N5 O3 c1cc(cc(c1....
45 1GIJ - 2PU C19 H22 N6 O2 c1cc2c(c(c....
46 2R3P ic50 = 900 nM 3SC C19 H12 Cl2 N6 S c1cc(c(c(c....
47 1KE8 ic50 = 1000 nM LS4 C18 H14 N4 O3 S2 c1ccc2c(c1....
48 2C6I ic50 = 11 uM DT1 C18 H22 N6 O3 S c1cc(ccc1N....
49 1PXP Ki = 0.22 uM CK8 C17 H19 N5 S Cc1c(sc(n1....
50 6Q3C - BYZ C3 H3 Br N2 c1c(cn[nH]....
51 2UZN ic50 = 0.03 uM C96 C15 H13 N3 O4 S2 [H]/N=C/1N....
52 2B55 ic50 = 96 nM D31 C24 H31 N5 O2 c1cc-2c(c(....
53 5K4J - 6QB C21 H18 Cl F N6 O2 Cn1c(ccn1)....
54 3PJ8 - 404 C19 H26 N6 O CC[C@H](CO....
55 3LFQ - A28 C17 H15 F2 N3 O CCCC(=O)Nc....
56 2W05 ic50 = 0.001 uM FRT C20 H26 N6 O3 S Cc1ncc(n1C....
57 2XNB Ki = 149 nM Y8L C19 H22 N6 O S CC1=C(SC(=....
58 1HCK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
59 5IEX - 6AF C17 H21 Br N4 O3 S C[C@H]([C@....
60 2R3H ic50 = 20000 nM SCE C13 H13 N5 Cc1cnc2n1c....
61 3LFN ic50 = 3160 nM A27 C23 H21 N3 O2 CCCC(=O)Nc....
62 3PY1 Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
63 2A4L ic50 = 0.4 uM RRC C19 H26 N6 O CC[C@H](CO....
64 1Y8Y ic50 = 2 uM CT7 C13 H11 Cl N4 O2 S CS(=O)(=O)....
65 6GUH Kd = 26 nM FB8 C18 H21 N5 O2 S Cc1ncc(n1C....
66 1OIR ic50 = 0.032 uM HDY C23 H26 N6 O2 Cc1c(n2ccc....
67 1PXJ - CK2 C9 H10 N4 S Cc1c(sc(n1....
68 2VTO ic50 = 0.14 uM LZ8 C17 H13 F N4 O2 c1ccc(cc1)....
69 2BTR ic50 = 95 nM U73 C13 H15 N3 O S CC(C)C1=CN....
70 6Q4K - HHW C16 H12 Cl N O3 c1cc(cc(c1....
71 2VTA ic50 = 185 uM LZ1 C7 H6 N2 c1ccc2c(c1....
72 3EZR - EZR C26 H27 N7 O CN1CCN(CC1....
73 3ULI ic50 = 0.07 uM 1N3 C21 H25 Br N6 O2 COc1ccc(cc....
74 2DS1 ic50 = 3.4 nM 1CD C22 H21 N5 O3 C[C@@H]1C[....
75 5FP5 - 1Y6 C7 H5 F O2 c1cc(ccc1C....
76 2VTH ic50 = 120 uM LZ2 C10 H9 N O3 S c1cc2c(ccc....
77 1KE5 ic50 = 560 nM LS1 C16 H15 N3 O3 S CNS(=O)(=O....
78 3FZ1 - B98 C13 H15 N3 O2 S COc1ccc2c(....
79 1WCC ic50 = 350 uM CIG C4 H4 Cl N3 c1c(nc(cn1....
80 1PXO Ki = 2 nM CK7 C14 H12 N6 O2 S Cc1c(sc(n1....
81 1H00 ic50 = 38 uM FAP C21 H23 F2 N5 O2 CN(C)C[C@@....
82 2R3R - 6SC C18 H14 Br N5 c1ccc(cc1)....
83 1B39 Kd = 0.12 uM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
84 6Q4C - HH8 C8 H5 Br N2 c1cc2c(ccn....
85 3PXF Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
86 3TI1 - B49 C22 H27 F N4 O2 CCN(CC)CCN....
87 2R3G ic50 = 800 nM SC9 C18 H14 F N5 c1ccc(c(c1....
88 2C69 ic50 = 26 uM CT8 C17 H14 Br N6 c1cc(cc(c1....
89 2VTM ic50 ~ 1 mM LZM C7 H4 N4 c1cnc2c(cn....
90 4ERW - STU C28 H26 N4 O3 C[C@@]12[C....
91 1E1V Ki = 12 uM CMG C12 H17 N5 O c1[nH]c2c(....
92 2VV9 ic50 = 0.017 uM IM9 C23 H29 N7 O2 Cc1ncc(n1C....
93 5IEV - R0N C18 H23 F3 N4 O3 S C[C@H]([C@....
94 6Q48 - HHQ C5 H4 I N O C1C(=CC=NC....
95 4D1X - ESJ C11 H8 N2 O3 S2 c1cc2c(cc1....
96 5MHQ - 8QT C19 H27 N7 O CC[C@@H]([....
97 2BTS ic50 = 20 nM U32 C12 H15 N3 O2 S2 CC(C)c1cnc....
98 6Q4D - HHT C9 H9 Br O3 COc1cc(ccc....
99 1URW ic50 < 0.003 uM I1P C21 H24 N8 O2 S CN(C)CCCNS....
100 5FP6 - MFZ C11 H7 Cl2 N O c1cc(c2c(c....
101 1CKP - PVB C20 H25 Cl N6 O3 CC(C)[C@H]....
102 1KE6 ic50 = 5.7 nM LS2 C17 H15 N5 O3 S2 CNS(=O)(=O....
103 2C6K ic50 = 0.73 uM DT2 C17 H21 N7 O2 S c1cc(ccc1N....
104 6Q4F - 26D C5 H7 N3 c1cc(nc(c1....
105 2R3Q - 5SC C19 H16 Br N5 O Cc1ccccc1c....
106 1OIT ic50 < 0.003 uM HDT C17 H14 N6 O2 S c1ccn2c(c1....
107 3NS9 ic50 = 0.003 uM NS9 C20 H27 N5 O3 CC(C)c1cnn....
108 6Q4I - HGK C13 H11 N O4 c1cc(ccc1C....
109 1H01 ic50 = 22 uM FAL C21 H23 Cl2 N5 O2 CN(C)C[C@H....
110 2EXM - ZIP C10 H13 N5 CC(=CCNc1c....
111 4BGH ic50 = 4 nM 3I6 C13 H16 Br N5 O3 S C[C@H](CO)....
112 2R3F ic50 = 500 nM SC8 C18 H13 Cl2 N5 c1cc(c(c(c....
113 1GII - 1PU C17 H16 N4 O2 c1ccnc(c1)....
114 6Q4B - HHN C4 H3 Br N2 c1c(cncn1)....
115 2R64 ic50 = 0.03 uM 740 C23 H27 N5 O3 S c1cc(ccc1C....
116 5A14 - LQ5 C24 H26 F3 N7 O2 CN1CCN(CC1....
117 2C6L ic50 = 0.27 uM DT4 C17 H22 N8 O2 S c1cc(ccc1N....
118 2W06 - FRV C18 H20 N6 O2 S Cc1ncc(n1C....
119 4EZ7 - STU C28 H26 N4 O3 C[C@@]12[C....
120 6Q4J - HHB C12 H11 N3 O2 c1cc(cc(c1....
121 5D1J ic50 = 48 nM 56H C17 H24 N4 O2 S2 CC(C)(C)c1....
122 5IEY - 6AE C14 H19 N5 O3 S C[C@H]([C@....
123 2VTT ic50 = 0.044 uM LZD C16 H17 F2 N5 O2 c1cc(c(c(c....
124 2VU3 ic50 = 0.047 uM LZE C16 H17 Cl2 N5 O2 c1cc(c(c(c....
125 2B54 - D05 C20 H15 Cl3 N4 O3 CCc1c2c(n(....
126 1GZ8 - MBP C10 H13 N5 O2 CC(C)C(=O)....
127 3PY0 ic50 = 0.13 uM SU9 C13 H11 N3 O2 COc1ccc2c(....
128 2VTR ic50 = 1.5 uM LZB C10 H10 Cl N5 CC(C)Nc1cc....
129 1E1X Ki = 1.3 uM NW1 C11 H17 N5 O2 C1CCC(CC1)....
130 3UNJ ic50 = 11 uM 0BX C17 H14 N4 O2 c1ccc(cc1)....
131 2A0C - CK9 C19 H26 N6 O2 CC[C@H](CO....
132 3TIY - TIY C11 H8 O5 c1c2c(c(c(....
133 2R3I ic50 = 1000 nM SCF C18 H14 F N5 c1ccc(c(c1....
134 1VYZ ic50 = 290 nM N5B C13 H13 N3 O c1ccc(cc1)....
135 3WBL ic50 = 23 uM PDY C20 H26 N6 O CCOc1ccc(c....
136 4RJ3 ic50 = 93 nM 3QS C22 H28 N6 O COC1CCN(CC....
137 2VTN ic50 = 0.85 uM LZ7 C12 H11 F N4 O2 CC(=O)Nc1c....
138 1AQ1 - STU C28 H26 N4 O3 C[C@@]12[C....
139 2C6M ic50 = 0.35 uM DT5 C17 H20 N6 O3 S c1cc(ccc1N....
140 2R3L ic50 = 100 nM SCW C18 H14 Br N5 c1ccc(cc1)....
141 6Q4A - HGW C4 H3 I N2 c1c(cncn1)....
142 1H08 - BYP BWP n/a n/a
143 1B38 Kd = 0.254 uM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
144 2B52 ic50 = 8 nM D42 C21 H23 N7 O2 S Cc1c(sc(n1....
145 1PXL - CK4 C16 H13 F3 N4 S Cc1c(sc(n1....
146 3S2P ic50 = 0.068 uM PMU C17 H22 N4 O3 CC(C)c1cc(....
147 2R3O ic50 = 600 nM 2SC C19 H17 N5 O c1ccc(cc1)....
148 3IGG ic50 = 95 nM EFQ C16 H19 N3 O3 COc1ccc(cc....
149 1R78 ic50 = 3 nM FMD C20 H20 F N3 O4 C[C@H]([C@....
150 2FVD Ki = 0.003 uM LIA C18 H21 F2 N5 O4 S COc1ccc(c(....
151 2VTL ic50 = 97 uM LZ5 C10 H9 N3 O c1ccc(cc1)....
152 1KE9 ic50 = 660 nM LS5 C16 H15 N5 O3 S c1ccc2c(c1....
153 6Q3B - PYZ C3 H3 I N2 c1c(cn[nH]....
154 1PYE Ki = 386 nM PM1 C21 H13 F2 N3 O2 c1ccc(cc1)....
155 6Q49 - HGQ C5 H4 Br N O C1=CNC(=O)....
156 4EZ3 - 0S0 C11 H10 N4 O4 S c1cc(ccc1/....
157 1H07 ic50 = 3 uM MFP C24 H27 Br N6 O2 Cc1ccc(c(c....
158 2B53 ic50 = 0.6 uM D23 C19 H19 F3 N4 CC(C)(C)Nc....
159 6GUK Kd = 715 nM FC8 C19 H24 Cl N7 CCn1cnc2c1....
160 2DUV ic50 = 0.087 uM 371 C19 H17 N O7 S Cc1cc2c(c(....
161 4D1Z - WG8 C13 H10 N2 O3 S c1cc2ccc(n....
162 6Q4E Kd = 350 uM HH5 C5 H4 I N5 c1[nH]c2c(....
163 4ACM Ki = 210 nM 7YG C20 H23 N7 O3 S CN(C)CCNS(....
164 2C5Y ic50 = 0.25 uM MTW C19 H15 N7 O2 c1cc(cc(c1....
165 6Q4G Kd = 50 uM HJK C13 H11 N5 O2 c1cc(cc(c1....
166 2R3K ic50 = 100 nM SCQ C18 H14 Br N5 c1ccc(cc1)....
167 2V0D - C53 C9 H7 N3 O S [H]/N=C1/N....
168 2W1H ic50 = 0.052 uM L0F C17 H13 N5 O c1ccc(cc1)....
169 1Y91 ic50 = 0.059 uM CT9 C23 H33 N7 O2 S CC(C)c1cnn....
170 4AU8 ic50 = 551 nM Z3R C11 H8 N2 O2 S3 c1ccc2c(c1....
171 1V0P ic50 = 0.13 uM PVB C20 H25 Cl N6 O3 CC(C)[C@H]....
172 1V0O ic50 = 5.5 uM INR C16 H10 N2 O5 S c1ccc2c(c1....
50% Homology Family (195)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 70 families.
1 2YM8 ic50 = 0.013 uM YM8 C19 H19 Cl N6 O C[C@H](CN(....
2 5OPU Ki = 0.053 uM A3K C15 H12 N4 Cc1cccc(c1....
3 5OP4 Ki = 0.194 uM A0T C19 H21 F4 N5 O3 CCNc1c(cnc....
4 2CGW ic50 = 17.3 uM 3C3 C9 H15 N9 O2 CCCn1c(nc(....
5 3F9N ic50 = 1.3 uM 38M C29 H35 Cl N4 O2 S CCCC[C@@H]....
6 4JIK ic50 = 0.018 uM 1KO C18 H19 Cl N6 O c1cc(ccc1c....
7 4QYH ic50 = 0.0013 uM 3DX C22 H20 N6 CN1CCN(CC1....
8 2BRB Ki = 13.7 uM PFQ C20 H17 N3 O2 c1ccc(cc1)....
9 3PA3 ic50 = 1 nM C70 C18 H18 Cl N5 O S c1cc(ccc1c....
10 5OQ6 Ki = 0.0277 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
11 6FCF ic50 = 0.006 uM D58 C20 H22 N4 O S C[C@@H]1[C....
12 2YER ic50 = 0.02 uM TQ1 C15 H12 N4 O2 c1cc([nH]c....
13 2E9O ic50 = 20 nM A58 C25 H27 N3 O2 CC1CCC(CC1....
14 5OPB Ki = 0.0241 uM A1N C21 H25 N5 O2 C[C@@H]1CN....
15 2WMQ - ZYQ C9 H11 N3 O2 S CC(=O)Nc1n....
16 2BRO ic50 = 1.4 uM DF2 C21 H20 N4 O2 c1ccc(cc1)....
17 2QHN ic50 = 980 nM 582 C13 H13 N3 O CCN1c2cccc....
18 4RVM ic50 = 1 nM 3X7 C23 H21 N5 c1cc(ccc1C....
19 5DLS ic50 = 4.4 nM 5CV C31 H34 N6 O3 CC(C)(CN(C....
20 3TKI ic50 = 0.05 nM S25 C20 H23 N7 O2 S c1cnc(cc1N....
21 2YM5 ic50 = 0.43 uM YM5 C18 H21 N5 O2 c1cc(cc(c1....
22 4HYH ic50 = 1 nM 1AM C22 H22 N6 O3 S COc1ccc2c(....
23 5OPV Ki = 0.0515 uM A3H C19 H16 N6 Cc1cccc(c1....
24 5OOT Ki = 0.0285 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
25 1NVS Ki = 15 nM UCM C24 H15 N3 O3 c1ccc2c(c1....
26 2YDK ic50 = 0.007 uM YDK C17 H20 N4 O2 S c1ccc(cc1)....
27 3OT3 ic50 = 0.005 uM 22K C16 H20 Br N7 Cn1cc(cn1)....
28 2HXQ ic50 = 144 nM 373 C24 H26 N4 O c1ccc2c(c1....
29 2QHM ic50 = 660 nM 7CS C16 H19 N3 O2 CN1[C@H]2C....
30 2BRH ic50 = 22.9 uM DFW C20 H15 N3 O3 c1ccc(cc1)....
31 2R0U ic50 = 1 nM M54 C25 H22 N4 O2 c1cc(cc(c1....
32 1NVR Ki = 7.8 nM STU C28 H26 N4 O3 C[C@@]12[C....
33 3OT8 ic50 = 0.009 uM MI5 C19 H22 N8 S Cc1cc(sn1)....
34 2YM4 ic50 = 1.5 uM 4YM C21 H22 N6 O3 CCOC(=O)c1....
35 4HYI ic50 = 3 nM 1AO C21 H20 N6 O S c1ccc2c(c1....
36 4RVL ic50 = 41.7 nM 3XL C17 H10 N4 O c1ccc(c(c1....
37 5JQ5 Kd = 2341 nM I74 C22 H30 N6 O CC(C)c1cnn....
38 2C6O - 4SP C18 H22 N6 O3 S c1cc(ccc1N....
39 1V1K ic50 = 35 uM 3FP C22 H23 F4 N5 O2 CN(C)C[C@H....
40 2VTJ ic50 = 1.9 uM LZ4 C10 H9 Cl N4 O2 S c1cc(ccc1N....
41 3EZV - EZV C25 H25 N7 CN1CCN(CC1....
42 3PXZ Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
43 1W0X - OLO C15 H18 N6 O Cn1cnc2c1n....
44 2XMY Ki = 0.11 nM CDK C18 H21 N5 O4 S2 CC1=C(SC(=....
45 2UZO ic50 = 27 uM C62 C14 H10 N2 O5 S2 c1cc(ccc1c....
46 1KE7 ic50 = 8.9 nM LS3 C20 H15 N3 O4 S c1cc2c(cc1....
47 1DM2 - HMD C11 H10 Br N5 O2 C1CNC(=O)C....
48 1DI8 ic50 = 1 uM DTQ C16 H15 N3 O3 COc1cc2c(c....
49 5JQ8 - I73 C22 H30 N6 O CC(C)c1cnn....
50 6Q4H - HGH C13 H11 N5 O3 c1cc(cc(c1....
51 1GIJ - 2PU C19 H22 N6 O2 c1cc2c(c(c....
52 2R3P ic50 = 900 nM 3SC C19 H12 Cl2 N6 S c1cc(c(c(c....
53 1KE8 ic50 = 1000 nM LS4 C18 H14 N4 O3 S2 c1ccc2c(c1....
54 2C6I ic50 = 11 uM DT1 C18 H22 N6 O3 S c1cc(ccc1N....
55 1PXP Ki = 0.22 uM CK8 C17 H19 N5 S Cc1c(sc(n1....
56 6Q3C - BYZ C3 H3 Br N2 c1c(cn[nH]....
57 2UZN ic50 = 0.03 uM C96 C15 H13 N3 O4 S2 [H]/N=C/1N....
58 2B55 ic50 = 96 nM D31 C24 H31 N5 O2 c1cc-2c(c(....
59 5K4J - 6QB C21 H18 Cl F N6 O2 Cn1c(ccn1)....
60 3PJ8 - 404 C19 H26 N6 O CC[C@H](CO....
61 3LFQ - A28 C17 H15 F2 N3 O CCCC(=O)Nc....
62 2W05 ic50 = 0.001 uM FRT C20 H26 N6 O3 S Cc1ncc(n1C....
63 2XNB Ki = 149 nM Y8L C19 H22 N6 O S CC1=C(SC(=....
64 1HCK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
65 5IEX - 6AF C17 H21 Br N4 O3 S C[C@H]([C@....
66 2R3H ic50 = 20000 nM SCE C13 H13 N5 Cc1cnc2n1c....
67 5LI9 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
68 3A8W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
69 3OWL ic50 = 0.67 uM 19E C16 H11 Cl N2 O Cc1cnc(c2c....
70 5OYF - B4Q C25 H27 N3 CCc1ccccc1....
71 5H8G Kd = 48.2 pM 5Y4 C23 H29 N9 O CC(=O)Nc1c....
72 5OS7 - A8Q C16 H19 Cl N CC(C)c1ccc....
73 6YPJ - P5W C16 H12 N2 O2 S c1ccc(cc1)....
74 5OTZ Kd = 6.5 uM AUT C15 H15 Cl2 N CCc1ccccc1....
75 6HOQ - FER C10 H10 O4 COc1cc(ccc....
76 5OUM - AVK C18 H18 Cl N3 c1ccc(cc1)....
77 5B0X ic50 = 0.02 uM HCK C18 H14 N2 O4 S COc1ccc(cc....
78 5MO8 Kd = 1.64 uM C98 C26 H26 Cl N3 O4 c1ccc(cc1)....
79 6RCB ic50 = 0.33 uM JYZ C17 H14 N2 O4 COc1cc(ccc....
80 3R1N - 05B C22 H21 N5 O3 c1cc2c(cc1....
81 3BWJ Kd = 0.319 uM ARX C28 H47 N15 O7 [H]/N=C(N)....
82 6SPS - LR5 C8 H6 F3 N O c1cc(ccc1C....
83 6SPM - 3AE C8 H5 F3 O2 c1cc(ccc1C....
84 3AGL Ki = 16 nM A03 C37 H63 N17 O9 [H]/N=C(N)....
85 6SNX - UNU C7 H7 N O c1ccc(cc1)....
86 6ZN0 - NTN C6 H7 N3 c1cnccc1C(....
87 6SNN - BEZ C7 H6 O2 c1ccc(cc1)....
88 1RE8 Ki = 0.3 nM BD2 C27 H26 N2 O6 c1ccc(c(c1....
89 1SZM ic50 = 2.94 uM BI4 C27 H26 N4 O2 C[N@]1CCC[....
90 1REJ Ki = 5 nM B1L C20 H22 N2 O5 c1cc(ccc1C....
91 6SPY - LR8 C10 H13 N3 O2 c1cc(ncc1C....
92 6Z08 - NPO C6 H5 N O3 c1cc(ccc1[....
93 2Z7Q - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
94 1MQ4 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
95 6C2R Ki = 0.8 nM EG7 C24 H26 Cl F2 N5 O2 Cc1cc(n[nH....
96 5EW9 Ki < 0.01 nM 5VC C22 H21 Cl F N3 O3 S c1cc(nc(c1....
97 5ORY Kd = 357 uM AY4 C9 H6 F2 N2 O c1c[nH]nc1....
98 4CEG - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
99 6VPH - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
100 5ORV Kd = 1297 uM A65 C6 H9 N O S3 CSc1c(c(sn....
101 5OS6 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
102 3DJ6 - AK6 C25 H24 N4 O3 S COc1ccc(cc....
103 5OSF - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
104 2WQE - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
105 6CPF - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
106 6R4C - JRQ C16 H22 N2 O3 CCOC(=O)C[....
107 3FDN ic50 = 0.033 uM MMH C21 H22 N6 O3 Cc1c(c([nH....
108 5OOI - 9YE C23 H25 N O3 CC(C)n1c2c....
109 7A1Z ic50 = 3.38 uM QWN C5 H2 Br Cl N4 c1c2c(nc(c....
110 3KXH - K66 C11 H9 Br4 N3 O2 CN(C)c1nc2....
111 4DGM ic50 = 1.2 uM AGI C15 H10 O5 c1cc(ccc1C....
112 3PVG - K68 C9 H4 Br4 N2 O2 c1nc2c(n1C....
113 1ZOG Ki = 0.07 uM K37 C8 H4 Br4 N2 S CSc1[nH]c2....
114 2PVJ Ki = 0.005 uM P44 C19 H21 N7 c1ccc(cc1)....
115 1P4F - DRG C12 H11 N3 c1ccc-2c(c....
116 4TXC Kd = 0.24 uM 38G C24 H27 N5 O3 CN(C)CCN[C....
117 2YAK ic50 = 2 nM OSV C27 H31 F N4 O3 Ru S4 CC(C)Oc1cc....
118 5AUY ic50 = 1.6 uM MRI C15 H10 O7 c1cc(c(cc1....
119 2HY0 ic50 = 0.65 nM 306 C26 H25 N5 O c1cc2c(cc1....
120 5LVO - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
121 4XX9 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
122 2XCK ic50 = 713 nM MH4 C29 H33 N9 O Cc1cc(ccn1....
123 3QD4 ic50 = 6.31 nM 3Q6 C22 H30 N8 O2 C[C@@H]1C[....
124 3RCJ ic50 = 0.8 uM 3RC C16 H13 N5 c1ccc(cc1)....
125 2PE0 - 39Z C14 H12 N2 O2 CC(c1ccc[n....
126 4CT2 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
127 5ACK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
128 3HRC - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
129 5LVM - ADE C5 H5 N5 c1[nH]c2c(....
130 5MRD ic50 = 36.4 uM S26 C18 H13 Cl N2 O4 S2 CCOC(=O)C1....
131 3ION ic50 = 8 nM 8H1 C28 H27 N5 O3 COc1cc2c3c....
132 1UU7 ic50 = 14 uM BI2 C27 H26 N4 O2 C[N@@]1CCC....
133 3HRF Kd = 10.3 uM P47 C17 H15 Cl O2 c1ccc(cc1)....
134 3QCS ic50 = 0.316 uM 3Q1 C15 H17 N7 O c1cc2c(cc1....
135 1H1W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
136 4AW1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
137 2PE2 - 464 C28 H30 N6 O3 c1cc(cc(c1....
138 3H9O ic50 = 70 nM 9BD C19 H19 N5 O3 COCCOc1cc2....
139 3QD3 ic50 = 0.00000001 M 3Q5 C22 H30 N8 O2 C[C@H]1CC[....
140 1OKY ic50 = 6.5 nM STU C28 H26 N4 O3 C[C@@]12[C....
141 3IOP ic50 = 17 nM 8I1 C28 H27 N5 O3 COc1cc2c3c....
142 2PE1 ic50 = 6 nM 517 C15 H14 N4 O2 CC(c1ccc[n....
143 3RWP Ki = 0.6 nM ABQ C24 H24 F N7 O2 CC(C)n1cc(....
144 3NAX - MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
145 3QCQ ic50 = 0.158 uM 3Q0 C13 H15 N7 CCNc1cc(nc....
146 4A06 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
147 2R5T - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
148 2JDO ic50 = 0.23 uM I5S C20 H22 Cl N3 O3 S c1cc2cnccc....
149 1O6K - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
150 3E88 Ki = 2 nM G96 C24 H27 N7 O3 CCn1c2cc(n....
151 2UW9 - GVP C20 H20 Cl N3 c1cc(ccc1c....
152 2JDR ic50 = 0.5 nM L20 C24 H23 N5 O Cc1c2cc(cc....
153 3D0E ic50 = 13 nM G93 C21 H27 N7 O3 CCn1c2c(cn....
154 3UBD Kd = 2.9 uM SL0 C25 H24 O12 CC1C(C(C(C....
155 4GUE Kd = 5.8 uM QCT C21 H20 O11 C[C@H]1[C@....
156 3G51 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
157 4NUS ic50 = 0.005 uM 2NK C22 H21 F2 N3 O CN1CCN(CC1....
158 4NW6 ic50 = 0.004 uM 2NS C23 H20 N4 O4 COc1cc(cc(....
159 4NW5 ic50 = 0.02 uM 2NR C23 H21 F N2 O5 COc1cccc(c....
160 2W7X ic50 = 24 nM D1A C18 H17 N7 O3 [H]/N=C(N)....
161 4A9U - A9U C27 H28 N4 O2 c1ccc(cc1)....
162 2YCF ic50 = 0.03 nM YCF C19 H24 N10 O3 [H]/N=C(N/....
163 4BDI ic50 = 227.7 uM HAU C14 H19 N3 O2 Cc1ccc(nc1....
164 2YCR ic50 = 69.6 nM HCW C23 H28 N10 O C/C(=NNC1=....
165 2WTJ ic50 = 0.7 uM WTJ C16 H20 N4 O3 S CN(C)CCNC(....
166 4BDB ic50 = 85.6 uM ODO C8 H9 N O3 C/C(=NO)/c....
167 2YIT ic50 = 0.29 nM YIT C21 H24 N6 O2 CCC/C(=NNC....
168 2W0J ic50 = 240 nM ZAT C19 H24 N10 O [H]/N=C(N)....
169 6CCY ic50 = 0.003 uM EX4 C29 H33 F4 N7 O C[C@@H]1CC....
170 3QKK - SMH C28 H38 N2 O7 S CCOCCN(C[C....
171 6NPZ - GLY ARG PRO ARG THR THR ZXW PHE ALA GLU n/a n/a
172 4EKL ic50 = 5 nM 0RF C24 H32 Cl N5 O2 C[C@@H]1C[....
173 3CQW ic50 = 42 nM CQW C12 H11 Cl N6 c1c(c2c([n....
174 4GV1 ic50 = 3 nM 0XZ C21 H25 Cl N6 O2 c1cc(ccc1[....
175 3MVH ic50 = 0.5 nM WFE C20 H22 F2 N6 O CCc1c[nH]c....
176 3MV5 ic50 = 180 nM XFE C11 H15 N5 Cc1c[nH]c2....
177 3QKL - SMR C29 H40 N4 O5 S CCOCC[N@@]....
178 5OTF - AQ5 C20 H24 N6 c1cnc2c(c1....
179 3TKU ic50 = 1.92 uM M77 C14 H17 N3 O2 S c1cc2cnccc....
180 3V8S ic50 = 0.65 uM 0HD C16 H16 N4 O c1ccc(cc1)....
181 4OTH ic50 = 9 nM DRN C25 H23 N5 O2 S [H]/N=C(/N....
182 3A62 - STU C28 H26 N4 O3 C[C@@]12[C....
183 3WF9 ic50 = 567 nM FS7 C24 H25 N3 O5 S C[C@H]1CCc....
184 3WF8 ic50 = 232 nM F76 C23 H23 N3 O5 S c1ccc2c(c1....
185 4L3L - 5FI C19 H21 F3 N6 CCc1cncnc1....
186 3WE4 ic50 = 15 nM 5FI C19 H21 F3 N6 CCc1cncnc1....
187 3WF5 ic50 = 81 nM FZ8 C17 H17 N7 c1ccc2c(c1....
188 2F2U - M77 C14 H17 N3 O2 S c1cc2cnccc....
189 6C0T ic50 = 43.1 nM EE4 C30 H30 F N5 O5 CCCOc1ccc(....
190 6BXI - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
191 5F9E ic50 = 0.46 nM 5VS C23 H21 N5 O2 CC1(NC(=O)....
192 1XJD Ki = 0.33 nM STU C28 H26 N4 O3 C[C@@]12[C....
193 3TXO ic50 = 9 nM 07U C17 H19 N5 CC(C)(CNc1....
194 1V0P ic50 = 0.13 uM PVB C20 H25 Cl N6 O3 CC(C)[C@H]....
195 1V0O ic50 = 5.5 uM INR C16 H10 N2 O5 S c1ccc2c(c1....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 2AN; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 2AN 1 1
Ligand no: 2; Ligand: JWS; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 JWS 1 1
2 X11 0.404255 0.909091
Similar Ligands (3D)
Ligand no: 1; Ligand: 2AN; Similar ligands found: 302
No: Ligand Similarity coefficient
1 NYJ 0.9350
2 8SK 0.9331
3 5NN 0.9315
4 3GX 0.9239
5 96U 0.9212
6 E2Q 0.9207
7 CU5 0.9203
8 MFR 0.9200
9 M3W 0.9153
10 3WN 0.9132
11 3WO 0.9132
12 1EL 0.9120
13 FYJ 0.9111
14 UXH 0.9102
15 3WK 0.9088
16 DY5 0.9064
17 W8L 0.9057
18 BJ4 0.9050
19 VT3 0.9050
20 VAR 0.9049
21 34L 0.9047
22 8CA 0.9044
23 3WJ 0.9043
24 TXQ 0.9040
25 E9L 0.9033
26 SGW 0.9027
27 IDD 0.9023
28 H2W 0.9021
29 5V7 0.9014
30 5DN 0.9012
31 CDJ 0.9011
32 9TF 0.9007
33 MHR 0.9002
34 96R 0.9001
35 YJX 0.9000
36 3WL 0.8998
37 M3F 0.8990
38 YEX 0.8988
39 GI1 0.8985
40 C93 0.8983
41 3JN 0.8978
42 3JL 0.8978
43 CHQ 0.8978
44 9OF 0.8978
45 DBQ 0.8978
46 DX2 0.8976
47 B2L 0.8960
48 CGW 0.8953
49 KOM 0.8953
50 UX0 0.8951
51 PVK 0.8951
52 57D 0.8943
53 537 0.8943
54 PVQ 0.8941
55 EPK 0.8938
56 ER7 0.8935
57 5BN 0.8930
58 PK3 0.8929
59 TQ3 0.8920
60 11G 0.8920
61 GI3 0.8919
62 7M2 0.8914
63 X8E 0.8908
64 BIE 0.8907
65 PD6 0.8905
66 465 0.8904
67 RHN 0.8902
68 AFT 0.8902
69 2NJ 0.8901
70 CPW 0.8900
71 KN1 0.8899
72 HNA 0.8892
73 Q0K 0.8888
74 1V4 0.8883
75 KWG 0.8883
76 1V3 0.8879
77 OA4 0.8879
78 AP6 0.8878
79 5O4 0.8874
80 REF 0.8872
81 BHF 0.8872
82 XP0 0.8868
83 CG8 0.8865
84 L3L 0.8865
85 JVE 0.8863
86 UQ1 0.8862
87 ZSP 0.8856
88 2MQ 0.8855
89 X0T 0.8853
90 9E3 0.8850
91 1Q4 0.8849
92 KZ9 0.8844
93 DXK 0.8843
94 B52 0.8840
95 H52 0.8839
96 IQZ 0.8838
97 E1K 0.8835
98 2LX 0.8831
99 F40 0.8826
100 YK9 0.8823
101 7L4 0.8821
102 DYZ 0.8821
103 2GQ 0.8820
104 4WF 0.8817
105 OPA 0.8816
106 AN1 0.8815
107 7Z9 0.8811
108 ZJB 0.8810
109 LY2 0.8808
110 2N0 0.8808
111 7NU 0.8805
112 Q9P 0.8804
113 UI2 0.8802
114 KMP 0.8801
115 32V 0.8801
116 9Y5 0.8801
117 T02 0.8799
118 3JC 0.8799
119 P4L 0.8795
120 0Q2 0.8794
121 DY9 0.8792
122 56N 0.8790
123 JJ3 0.8788
124 GHT 0.8788
125 C8Z 0.8787
126 4KR 0.8785
127 OTA 0.8784
128 HMD 0.8783
129 9CE 0.8782
130 F5C 0.8781
131 MW5 0.8780
132 JAK 0.8778
133 7A9 0.8778
134 COL 0.8777
135 IBC 0.8777
136 7KB 0.8775
137 B2E 0.8774
138 GEN 0.8773
139 8HG 0.8772
140 3UG 0.8767
141 EMO 0.8766
142 QUE 0.8763
143 A73 0.8763
144 3KC 0.8759
145 U19 0.8758
146 7M5 0.8758
147 TQ1 0.8757
148 3AK 0.8756
149 TGW 0.8756
150 B2X 0.8755
151 B61 0.8754
152 AQN 0.8750
153 L5S 0.8749
154 1V1 0.8746
155 BC3 0.8745
156 JSN 0.8742
157 M4B 0.8742
158 340 0.8741
159 6DQ 0.8738
160 IMK 0.8737
161 25F 0.8736
162 EVO 0.8736
163 6BK 0.8734
164 P9I 0.8733
165 NPL 0.8731
166 3N4 0.8731
167 9Y8 0.8728
168 19E 0.8725
169 ALH 0.8723
170 H4B 0.8723
171 20D 0.8722
172 NRA 0.8722
173 BA5 0.8722
174 8P6 0.8717
175 S0I 0.8713
176 5WW 0.8711
177 5XL 0.8709
178 2T4 0.8708
179 22L 0.8707
180 64F 0.8706
181 NKI 0.8704
182 PZB 0.8704
183 1YL 0.8703
184 DFL 0.8702
185 RGK 0.8702
186 DX7 0.8699
187 RDL 0.8697
188 AGI 0.8694
189 6CD 0.8692
190 CZ0 0.8689
191 VGF 0.8688
192 ABJ 0.8686
193 FVV 0.8685
194 1GR 0.8681
195 5E2 0.8680
196 4E2 0.8679
197 A4V 0.8679
198 5WT 0.8678
199 CC6 0.8678
200 2QU 0.8678
201 JUO 0.8677
202 Y70 0.8670
203 NOM 0.8670
204 DLZ 0.8668
205 CX6 0.8668
206 O9Q 0.8667
207 JRO 0.8667
208 PQQ 0.8667
209 5E1 0.8665
210 9KQ 0.8664
211 3F4 0.8659
212 4E3 0.8658
213 GAT 0.8657
214 M77 0.8656
215 VUP 0.8656
216 BIO 0.8656
217 AJD 0.8656
218 UAY 0.8655
219 LU2 0.8654
220 SQM 0.8654
221 SZ5 0.8654
222 LFN 0.8654
223 36I 0.8654
224 IZA 0.8653
225 2QV 0.8653
226 AO6 0.8653
227 372 0.8650
228 AXX 0.8649
229 ST1 0.8644
230 3RQ 0.8642
231 IFM BGC 0.8640
232 T28 0.8640
233 B1V 0.8639
234 WLH 0.8636
235 1DR 0.8634
236 PIQ 0.8633
237 KY3 0.8632
238 Z21 0.8629
239 8DA 0.8628
240 C9B 0.8628
241 MQ1 0.8627
242 O9Z 0.8627
243 FNA 0.8625
244 74Z 0.8625
245 IBM 0.8625
246 29Q 0.8623
247 BRY 0.8622
248 EI1 0.8622
249 QNM 0.8621
250 CP6 0.8620
251 NAR 0.8618
252 GI4 0.8613
253 IXM 0.8612
254 AHQ 0.8612
255 3Y7 0.8610
256 AV6 0.8609
257 QZ8 0.8608
258 X04 0.8605
259 LP8 0.8605
260 SY9 0.8603
261 IQW 0.8601
262 5P3 0.8601
263 1QV 0.8601
264 5E4 0.8601
265 4KL 0.8598
266 HFT 0.8593
267 EQU 0.8592
268 8MO 0.8592
269 1D1 0.8590
270 NPZ 0.8585
271 64E 0.8585
272 1U7 0.8584
273 39Z 0.8583
274 3RR 0.8583
275 GWD 0.8582
276 XTS 0.8579
277 8HH 0.8576
278 62V 0.8575
279 1YE 0.8572
280 PLP 0.8572
281 E3U 0.8571
282 AB3 0.8569
283 A3Q 0.8569
284 K68 0.8569
285 E6Q 0.8567
286 ONZ 0.8566
287 2SK 0.8564
288 FC3 0.8563
289 K25 0.8562
290 KP2 0.8559
291 A0O 0.8558
292 3FE 0.8556
293 774 0.8552
294 MZC 0.8551
295 M9N 0.8551
296 5AD 0.8540
297 AZN 0.8540
298 54X 0.8540
299 EST 0.8537
300 HBI 0.8536
301 T6Z 0.8536
302 A1Y 0.8536
Ligand no: 2; Ligand: JWS; Similar ligands found: 315
No: Ligand Similarity coefficient
1 3RP 0.9611
2 IQQ 0.9542
3 L5D 0.9500
4 II4 0.9499
5 X2M 0.9407
6 Q4G 0.9400
7 JY4 0.9370
8 KCH 0.9366
9 28A 0.9352
10 H7S 0.9304
11 CK1 0.9268
12 UKV 0.9254
13 5F8 0.9253
14 HRM 0.9231
15 QKU 0.9227
16 30G 0.9226
17 CK2 0.9216
18 AUV 0.9216
19 0LO 0.9194
20 THM 0.9179
21 VAO 0.9165
22 XEV 0.9162
23 FQX 0.9161
24 3J8 0.9155
25 5C1 0.9150
26 LFN 0.9148
27 LUM 0.9143
28 TCR 0.9139
29 B2T 0.9137
30 L22 0.9136
31 AVA 0.9114
32 8G6 0.9110
33 BIK 0.9098
34 19E 0.9092
35 H70 0.9092
36 6ZW 0.9081
37 FC2 0.9078
38 27M 0.9078
39 LL1 0.9076
40 18E 0.9076
41 5TZ 0.9074
42 1XS 0.9070
43 IA2 0.9066
44 9UL 0.9066
45 ITE 0.9065
46 BZE 0.9065
47 CNI 0.9064
48 DPT 0.9062
49 N0Z 0.9059
50 XDK 0.9053
51 ANC 0.9051
52 MNX 0.9051
53 BIO 0.9051
54 6QF 0.9043
55 CZ0 0.9038
56 7G2 0.9034
57 WUB 0.9030
58 HBI 0.9025
59 6FB 0.9020
60 LFQ 0.9019
61 2JK 0.9018
62 64E 0.9017
63 0XT 0.9015
64 S98 0.9011
65 DBF 0.9009
66 NRA 0.9006
67 795 0.9004
68 L1T 0.9004
69 NIR 0.9003
70 AMR 0.8998
71 4GU 0.8996
72 DX2 0.8994
73 4G2 0.8990
74 XI7 0.8985
75 9CE 0.8979
76 5FL 0.8979
77 BPY 0.8976
78 7MX 0.8969
79 78Y 0.8969
80 VM1 0.8965
81 0UL 0.8963
82 4V2 0.8957
83 DT7 0.8956
84 D3G 0.8954
85 DXK 0.8952
86 6MW 0.8952
87 ZSP 0.8950
88 V2Z 0.8949
89 U14 0.8949
90 4AU 0.8947
91 IQZ 0.8945
92 3QV 0.8940
93 DK1 0.8938
94 PRL 0.8934
95 B21 0.8929
96 MR6 0.8924
97 ZME 0.8923
98 344 0.8922
99 5E5 0.8919
100 JG8 0.8918
101 DCZ 0.8917
102 B56 0.8916
103 34L 0.8913
104 H4B 0.8912
105 PUE 0.8908
106 2WU 0.8904
107 AJY 0.8904
108 TIY 0.8902
109 AA 0.8901
110 2J1 0.8900
111 KMY 0.8899
112 THA 0.8899
113 P1J 0.8898
114 S60 0.8896
115 F2W 0.8893
116 ONR 0.8893
117 3D1 0.8892
118 JP2 0.8886
119 49P 0.8885
120 E1K 0.8884
121 NFL 0.8883
122 5AD 0.8882
123 TIA 0.8879
124 XM5 0.8878
125 EAE 0.8876
126 JF8 0.8875
127 4HG 0.8874
128 FCD 0.8874
129 ANF 0.8873
130 DNQ 0.8871
131 5F5 0.8870
132 JRO 0.8869
133 5WT 0.8868
134 PIQ 0.8867
135 774 0.8867
136 TT4 0.8867
137 CKA 0.8865
138 DRG 0.8860
139 YE7 0.8859
140 2GQ 0.8859
141 64F 0.8855
142 EV2 0.8854
143 6L6 0.8850
144 V1T 0.8850
145 M3E 0.8848
146 4FF 0.8844
147 LLT 0.8842
148 9RM 0.8840
149 28B 0.8839
150 BGU 0.8828
151 272 0.8828
152 60L 0.8827
153 GNV 0.8825
154 M83 0.8825
155 2QU 0.8824
156 M3F 0.8823
157 M5H 0.8821
158 0NX 0.8821
159 HMD 0.8819
160 CB1 0.8815
161 JTA 0.8814
162 EWG 0.8813
163 3DT 0.8813
164 3VQ 0.8812
165 DX7 0.8809
166 EN1 0.8805
167 OCZ 0.8805
168 537 0.8803
169 P4L 0.8802
170 3C5 0.8802
171 X48 0.8801
172 5GT 0.8799
173 0SY 0.8799
174 GNM 0.8795
175 ZZA 0.8794
176 2UD 0.8794
177 FLF 0.8792
178 F40 0.8791
179 HH6 0.8790
180 PE2 0.8790
181 PEY 0.8789
182 DX1 0.8787
183 1X8 0.8786
184 39Z 0.8784
185 1DR 0.8783
186 AN3 0.8778
187 F16 0.8776
188 2D2 0.8774
189 3D8 0.8770
190 SU9 0.8770
191 1EL 0.8769
192 15E 0.8765
193 1A7 0.8763
194 5TY 0.8763
195 DDU 0.8761
196 MUR 0.8757
197 B98 0.8757
198 IDZ 0.8757
199 DUR 0.8756
200 5NN 0.8755
201 A9B 0.8754
202 TRP 0.8754
203 R20 0.8754
204 ZRK 0.8751
205 K8W 0.8751
206 7L4 0.8749
207 TXQ 0.8743
208 ODK 0.8742
209 YZ9 0.8737
210 LEL 0.8737
211 A73 0.8737
212 LDR 0.8737
213 RHN 0.8732
214 QR2 0.8730
215 68A 0.8729
216 1AJ 0.8728
217 ZEA 0.8726
218 MXD 0.8725
219 6JM 0.8725
220 9AP 0.8723
221 Z21 0.8721
222 GNJ 0.8721
223 GRI 0.8720
224 MR4 0.8718
225 581 0.8717
226 AH3 0.8709
227 P9I 0.8709
228 U98 0.8706
229 7ZL 0.8705
230 KMP 0.8705
231 YE6 0.8704
232 U7E 0.8703
233 0FR 0.8702
234 GNG 0.8701
235 HNA 0.8698
236 1V1 0.8695
237 833 0.8695
238 79W 0.8692
239 2LW 0.8691
240 363 0.8691
241 NOM 0.8690
242 ID2 0.8689
243 3WL 0.8686
244 XDL XYP 0.8683
245 HWB 0.8683
246 CUE 0.8680
247 801 0.8679
248 AH9 0.8676
249 LZ5 0.8676
250 RFZ 0.8675
251 0RY 0.8672
252 C4E 0.8670
253 38E 0.8670
254 JMG 0.8668
255 S0D 0.8665
256 1ZC 0.8664
257 AH6 0.8664
258 N91 0.8663
259 MD6 0.8658
260 22T 0.8656
261 CC6 0.8654
262 Y3L 0.8654
263 VUP 0.8650
264 FX5 0.8646
265 LIG 0.8645
266 HDU 0.8644
267 5VU 0.8642
268 5BX 0.8642
269 XYP XIF 0.8642
270 D2G 0.8641
271 8CC 0.8640
272 JGB 0.8639
273 BZJ 0.8639
274 9TF 0.8630
275 CX6 0.8630
276 ADL 0.8629
277 1YL 0.8628
278 3L1 0.8625
279 KWV 0.8624
280 GA2 0.8623
281 3SU 0.8622
282 20D 0.8620
283 ZRL 0.8617
284 PK3 0.8614
285 6JO 0.8612
286 FSE 0.8610
287 IQ5 0.8610
288 1V4 0.8607
289 HC8 0.8607
290 SQM 0.8606
291 8Y7 0.8605
292 Q9T 0.8603
293 BVD 0.8601
294 DFL 0.8600
295 WLH 0.8599
296 25F 0.8597
297 EMO 0.8595
298 47V 0.8593
299 U13 0.8588
300 9XZ 0.8588
301 U19 0.8587
302 BHF 0.8584
303 L03 0.8581
304 3GX 0.8580
305 XIF XYP 0.8579
306 LI7 0.8570
307 1V3 0.8570
308 HRD 0.8560
309 GNY 0.8556
310 AC2 0.8551
311 8SK 0.8551
312 0FS 0.8550
313 OAQ 0.8533
314 1FE 0.8518
315 8NX 0.8518
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2XMY; Ligand: CDK; Similar sites found with APoc: 45
This union binding pocket(no: 1) in the query (biounit: 2xmy.bio1) has 81 residues
No: Leader PDB Ligand Sequence Similarity
1 4OUC 5ID 4.69799
2 6JKM ADP 24.8322
3 3UIM ANP 32.8859
4 1U59 STU 33.101
5 4Y8D 49J 33.557
6 4U44 3D9 33.8926
7 4U44 3D9 33.8926
8 6F3G CJN 34.2373
9 5Y80 IRE 34.5638
10 3LXN MI1 34.5638
11 5AX9 4KT 34.8993
12 5AX9 4KT 34.8993
13 5WNL STU 34.8993
14 5WNL STU 34.8993
15 5AX9 4KT 34.8993
16 6OVA N9G 34.8993
17 4E1Z 0MX 35.7388
18 1BYG STU 36.3309
19 2H8H H8H 37.9195
20 3SRV S19 38.9892
21 2Z7R STU 39.9329
22 4G31 0WH 39.9329
23 4WNP 3RJ 40.4181
24 4WNP 3RJ 40.4181
25 3HMO STU 42.953
26 3HMO STU 42.953
27 3VRY B43 42.953
28 4JR7 GNP 44.6309
29 2V7O DRN 44.6309
30 2VZ6 FEF 44.9664
31 2VZ6 FEF 44.9664
32 6PJX SGV 45.302
33 2VN9 GVD 45.302
34 2VN9 GVD 45.302
35 4DC2 ADE 45.302
36 3GGF GVD 46.9799
37 3GGF GVD 46.9799
38 3GGF GVD 46.9799
39 3GGF GVD 46.9799
40 6QF4 ADP 46.9799
41 6YA6 0SX 47.3154
42 2ZV2 609 47.9866
43 6N3O KA7 48.3221
44 3C0G 3AM 48.6577
45 3IGO ANP 49.3289
46 6QAV HVH 50
47 6QAV HVH 50
48 6QAV HVH 50
49 6QAV HVH 50
50 3HZT J60 50
APoc FAQ
Feedback