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Receptor
PDB id Resolution Class Description Source Keywords
3P7G 1.5 Å NON-ENZYME: BINDING STRUCTURE OF THE HUMAN LANGERIN CARBOHYDRATE RECOGNITION DOM COMPLEX WITH MANNOSE HOMO SAPIENS C-TYPE LECTIN MEMBRANE PROTEIN GLYCOPROTEIN LANGERIN DC-CARBOHYDRATE BINDING PROTEIN CALCIUM BINDING SUGAR BINDINSYSTEM LANGERHANS CELLS CD207
Ref.: THE CARBOHYDRATE RECOGNITION DOMAIN OF LANGERIN REV STRUCTURAL SIMILARITY WITH THE ONE OF DC-SIGN BUT A ADDITIONAL, CALCIUM-INDEPENDENT SUGAR-BINDING SITE. MOL.IMMUNOL. V. 45 1981 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CA A:1;
B:1;
C:1;
D:1;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
submit data
40.078 Ca [Ca+2...
MAN A:339;
B:339;
C:339;
D:339;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
180.156 C6 H12 O6 C([C@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3P7G 1.5 Å NON-ENZYME: BINDING STRUCTURE OF THE HUMAN LANGERIN CARBOHYDRATE RECOGNITION DOM COMPLEX WITH MANNOSE HOMO SAPIENS C-TYPE LECTIN MEMBRANE PROTEIN GLYCOPROTEIN LANGERIN DC-CARBOHYDRATE BINDING PROTEIN CALCIUM BINDING SUGAR BINDINSYSTEM LANGERHANS CELLS CD207
Ref.: THE CARBOHYDRATE RECOGNITION DOMAIN OF LANGERIN REV STRUCTURAL SIMILARITY WITH THE ONE OF DC-SIGN BUT A ADDITIONAL, CALCIUM-INDEPENDENT SUGAR-BINDING SITE. MOL.IMMUNOL. V. 45 1981 2008
Members (15)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 510 families.
1 3P7G - MAN C6 H12 O6 C([C@@H]1[....
2 4N36 - 2F8 C9 H17 N O6 CC(=O)N[C@....
3 4N33 - NAG GAL BGC n/a n/a
4 3P5I - G6S NAG n/a n/a
5 3P5H - BGC BGC n/a n/a
6 4N37 - MMA C7 H14 O6 CO[C@@H]1[....
7 4N34 - 2F8 C9 H17 N O6 CC(=O)N[C@....
8 3P5E - MAN C6 H12 O6 C([C@@H]1[....
9 3P5D - MAN C6 H12 O6 C([C@@H]1[....
10 3P5G - FUC C6 H12 O5 C[C@H]1[C@....
11 4N32 - 2F8 C9 H17 N O6 CC(=O)N[C@....
12 3P7H - MAL C12 H22 O11 C([C@@H]1[....
13 4N38 - NAG GAL n/a n/a
14 4N35 - NAG GAL BGC n/a n/a
15 3P5F - MAN C6 H12 O6 C([C@@H]1[....
70% Homology Family (16)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 391 families.
1 3P7G - MAN C6 H12 O6 C([C@@H]1[....
2 4N36 - 2F8 C9 H17 N O6 CC(=O)N[C@....
3 4N33 - NAG GAL BGC n/a n/a
4 3P5I - G6S NAG n/a n/a
5 3P5H - BGC BGC n/a n/a
6 4N37 - MMA C7 H14 O6 CO[C@@H]1[....
7 4N34 - 2F8 C9 H17 N O6 CC(=O)N[C@....
8 3P5E - MAN C6 H12 O6 C([C@@H]1[....
9 3P5D - MAN C6 H12 O6 C([C@@H]1[....
10 3P5G - FUC C6 H12 O5 C[C@H]1[C@....
11 4N32 - 2F8 C9 H17 N O6 CC(=O)N[C@....
12 3P7H - MAL C12 H22 O11 C([C@@H]1[....
13 4N38 - NAG GAL n/a n/a
14 4N35 - NAG GAL BGC n/a n/a
15 3P5F - MAN C6 H12 O6 C([C@@H]1[....
16 5M62 - BGC C6 H12 O6 C([C@@H]1[....
50% Homology Family (10)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 298 families.
1 3P7G - MAN C6 H12 O6 C([C@@H]1[....
2 4N36 - 2F8 C9 H17 N O6 CC(=O)N[C@....
3 4N33 - NAG GAL BGC n/a n/a
4 3P5G - FUC C6 H12 O5 C[C@H]1[C@....
5 4N32 - 2F8 C9 H17 N O6 CC(=O)N[C@....
6 3P7H - MAL C12 H22 O11 C([C@@H]1[....
7 4N38 - NAG GAL n/a n/a
8 4N35 - NAG GAL BGC n/a n/a
9 3P5F - MAN C6 H12 O6 C([C@@H]1[....
10 5M62 - BGC C6 H12 O6 C([C@@H]1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: MAN; Similar ligands found: 142
No: Ligand ECFP6 Tc MDL keys Tc
1 WOO 1 1
2 GLC 1 1
3 BGC 1 1
4 ALL 1 1
5 BMA 1 1
6 GXL 1 1
7 GIV 1 1
8 GAL 1 1
9 MAN 1 1
10 GLA 1 1
11 Z6J 0.653846 0.866667
12 32O 0.653846 0.866667
13 RIB 0.653846 0.866667
14 FUB 0.653846 0.866667
15 AHR 0.653846 0.866667
16 MLB 0.511628 0.848485
17 GLC GLC 0.511628 0.848485
18 BGC GLC 0.511628 0.848485
19 BGC GLA 0.511628 0.848485
20 GLA BMA 0.511628 0.848485
21 MAN BMA 0.511628 0.848485
22 BMA GLA 0.511628 0.848485
23 GLA BGC 0.511628 0.848485
24 MAN MAN 0.511628 0.848485
25 GLA GLC 0.511628 0.848485
26 BMA MAN 0.511628 0.848485
27 GAL GLC 0.511628 0.848485
28 GAL GAL 0.511628 0.848485
29 LAK 0.511628 0.848485
30 GLC BGC 0.511628 0.848485
31 YDR 0.5 0.8
32 GLC GLC GLC GLC BGC 0.488889 0.848485
33 GLC GLC GLC 0.488889 0.848485
34 MAN MAN MAN 0.488889 0.848485
35 BMA MAN MAN 0.488889 0.848485
36 GLC GLC GLC GLC GLC BGC 0.488889 0.848485
37 EMZ 0.472222 0.794118
38 BG6 0.461538 0.675
39 BGP 0.461538 0.675
40 G6P 0.461538 0.675
41 M6P 0.461538 0.675
42 M6D 0.461538 0.675
43 A6P 0.461538 0.675
44 GAF 0.457143 0.875
45 SHG 0.457143 0.875
46 2FG 0.457143 0.875
47 G2F 0.457143 0.875
48 2H5 0.457143 0.875
49 GCS 0.457143 0.777778
50 1GN 0.457143 0.777778
51 X6X 0.457143 0.777778
52 PA1 0.457143 0.777778
53 95Z 0.457143 0.777778
54 G3F 0.457143 0.875
55 NGR 0.454545 0.848485
56 MAL 0.454545 0.848485
57 MAN GLC 0.454545 0.848485
58 GAL BGC 0.454545 0.848485
59 GLA GLA 0.454545 0.848485
60 BGC BMA 0.454545 0.848485
61 M3M 0.454545 0.848485
62 GLA GAL 0.454545 0.848485
63 MAB 0.454545 0.848485
64 GLC GAL 0.454545 0.848485
65 B2G 0.454545 0.848485
66 LBT 0.454545 0.848485
67 BMA GAL 0.454545 0.848485
68 LAT 0.454545 0.848485
69 BGC GAL 0.454545 0.848485
70 CBI 0.454545 0.848485
71 CBK 0.454545 0.848485
72 N9S 0.454545 0.848485
73 LB2 0.454545 0.848485
74 3MG 0.444444 0.875
75 TCB 0.444444 0.8
76 GLC SGC 0.444444 0.8
77 YIO 0.441176 0.870968
78 2GS 0.432432 0.875
79 2M4 0.431818 0.848485
80 AHR AHR 0.428571 0.764706
81 GLF 0.428571 0.84375
82 FUB AHR 0.428571 0.764706
83 MAN BMA BMA 0.416667 0.848485
84 BMA MAN BMA 0.416667 0.848485
85 CTR 0.416667 0.848485
86 BGC BGC BGC BGC BGC BGC BGC BGC BGC 0.416667 0.848485
87 GLA GAL BGC 0.416667 0.848485
88 CE5 0.416667 0.848485
89 MLR 0.416667 0.848485
90 CE6 0.416667 0.848485
91 MT7 0.416667 0.848485
92 BMA BMA BMA 0.416667 0.848485
93 GLC BGC BGC BGC BGC 0.416667 0.848485
94 MAN MAN BMA BMA BMA BMA 0.416667 0.848485
95 BGC BGC BGC BGC BGC 0.416667 0.848485
96 BGC GLC GLC GLC GLC GLC GLC 0.416667 0.848485
97 BGC GLC GLC 0.416667 0.848485
98 BMA BMA BMA BMA BMA 0.416667 0.848485
99 MAN BMA BMA BMA BMA 0.416667 0.848485
100 GLC GLC GLC GLC GLC GLC GLC GLC GLC 0.416667 0.848485
101 GLC BGC BGC BGC BGC BGC 0.416667 0.848485
102 MAN BMA BMA BMA BMA BMA 0.416667 0.848485
103 BGC BGC BGC BGC BGC BGC 0.416667 0.848485
104 BGC GLC GLC GLC 0.416667 0.848485
105 BGC BGC BGC GLC 0.416667 0.848485
106 CTT 0.416667 0.848485
107 GLA GAL GLC 0.416667 0.848485
108 MTT 0.416667 0.848485
109 GLC BGC BGC BGC 0.416667 0.848485
110 GLC GLC BGC 0.416667 0.848485
111 CEY 0.416667 0.848485
112 B4G 0.416667 0.848485
113 CE8 0.416667 0.848485
114 BMA BMA BMA BMA BMA BMA 0.416667 0.848485
115 GAL FUC 0.416667 0.848485
116 DXI 0.416667 0.848485
117 GLC BGC GLC 0.416667 0.848485
118 CT3 0.416667 0.848485
119 GAL GAL GAL 0.416667 0.848485
120 GLC GLC GLC GLC GLC 0.416667 0.848485
121 BGC BGC BGC BGC 0.416667 0.848485
122 BGC BGC BGC 0.416667 0.848485
123 BGC BGC GLC 0.416667 0.848485
124 CEX 0.416667 0.848485
125 GLC GAL GAL 0.416667 0.848485
126 BGC GLC GLC GLC GLC 0.416667 0.848485
127 GLC BGC BGC 0.416667 0.848485
128 GS1 GLC GS1 0.408163 0.8
129 SGC SGC BGC 0.408163 0.8
130 BGC BGC BGC GLC BGC BGC 0.408163 0.848485
131 GLC BGC BGC BGC BGC BGC BGC 0.408163 0.848485
132 1LL 0.405405 0.771429
133 TDG 0.405405 0.771429
134 TRE 0.405405 0.848485
135 NDG 0.404762 0.7
136 NGA 0.404762 0.7
137 NAG 0.404762 0.7
138 HSQ 0.404762 0.7
139 A2G 0.404762 0.7
140 BM3 0.404762 0.7
141 FUB AHR AHR 0.4 0.764706
142 AHR AHR AHR AHR AHR AHR 0.4 0.764706
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3P7G; Ligand: MAN; Similar sites found with APoc: 91
This union binding pocket(no: 1) in the query (biounit: 3p7g.bio2) has 10 residues
No: Leader PDB Ligand Sequence Similarity
1 2QX0 APC None
2 4MN3 ACE PHE ALA TYR M3L SER NH2 None
3 4UYE 9F9 None
4 3S2Y FMN None
5 5O2D 9HH 1.36986
6 2FZH DH1 2.05479
7 1I0S FMN 2.05479
8 1I0S NAP 2.05479
9 1TMM HHR 2.05479
10 1TMM APC 2.05479
11 2WOJ ADP ALF 2.05479
12 2ZV2 609 2.05479
13 5J1J ANP 2.05479
14 4QVB F42 2.73973
15 5BVA FAD 2.73973
16 3ZQ6 ADP ALF 2.73973
17 5N0F 7K2 2.73973
18 3E1T FAD 3.42466
19 1YOA FAD 3.42466
20 1DUV PSQ 3.42466
21 1FFU FAD 3.42466
22 1J71 THR ILE THR SER 3.42466
23 3E3U NVC 3.42466
24 1TKK ALA GLU 3.42466
25 4M38 SAH 4.10959
26 5XNC N4P 4.10959
27 4M37 SAH 4.10959
28 1USF FMN 4.10959
29 1USF NAP 4.10959
30 1XVB BHL 4.10959
31 4XTR ATP 4.10959
32 4XVU ATP 4.10959
33 1LSZ NDG NAG NAG NAG 4.10959
34 4XTR ADP 4.10959
35 1R9J TPP 4.79452
36 5LPA ATP 4.79452
37 5LPA 71R 4.79452
38 4KBA 1QM 4.79452
39 1KRH FAD 4.79452
40 5B6D C5P 4.79452
41 3UR0 SVR 5.47945
42 2IFW ACE PHE LYS PHE PSA LEU AAR 5.47945
43 6HT0 GQ8 5.47945
44 6DA9 FMN 5.47945
45 4DP3 MMV 5.47945
46 2OAT PFM 5.47945
47 1PVC ILE SER GLU VAL 5.47945
48 4YHB FAD 5.47945
49 5ETR APC 6.16438
50 5ETR 5RW 6.16438
51 3APT FAD 6.16438
52 5TCI 79V 6.16438
53 5BUK FAD 6.16438
54 3MJY IJZ 6.16438
55 3MJY FMN 6.16438
56 2VDH CAP 6.16438
57 1IR2 CAP 6.16438
58 3R5Z F42 6.2069
59 6CEP OXM 6.84932
60 6CEP NAD 6.84932
61 1M4I COA 6.84932
62 1M4I KAN 6.84932
63 3HCH RSM 6.84932
64 4FZV SAM 7.53425
65 5NVX 4YY 7.69231
66 4W9H 3JF 7.69231
67 4W9F 3JU 7.69231
68 4B9K TG0 7.69231
69 5WXH ALA ARG THR M3L GLN THR ALA 7.93651
70 5ND5 TPP 8.21918
71 1T0I FMN 8.21918
72 4WB7 ATP 8.21918
73 2D0N PRO SER ILE ASP ARG SER THR LYS PRO 8.47458
74 4BKS X6C 8.65385
75 6GWR FEW 8.90411
76 6FCX FAD 8.90411
77 5HI5 63Q 9.09091
78 4QLX FMN 10.9589
79 4QLX KTC 10.9589
80 2J83 BAT 12.3288
81 1PZM 5GP 13.0137
82 1BB6 UMG 13.1783
83 3PAK MAN 21.9178
84 1FKB RAP 25.2336
85 2GGX NPJ 35.6164
86 1G1T SIA GAL MAG FUC 36.3014
87 1PWB GLC GLC 36.9863
88 1PWB GLC 36.9863
89 4DN8 BMA 40.411
90 5JQ1 ZPF 40.6897
91 5KTI TRE 6X6 46.5753
Pocket No.: 2; Query (leader) PDB : 3P7G; Ligand: MAN; Similar sites found with APoc: 89
This union binding pocket(no: 2) in the query (biounit: 3p7g.bio4) has 13 residues
No: Leader PDB Ligand Sequence Similarity
1 4ITU NAI None
2 4ITU 1HS None
3 6ASZ GLN THR ALA ARG M3L SER None
4 2CYE COA None
5 2V1O COA None
6 6CDZ UMC None
7 6CDZ UMP None
8 4ISK UMP None
9 3DER ALA LYS 2.05479
10 5C79 PBU 2.05479
11 2Z7R STU 2.05479
12 4QIJ 1HA 2.73973
13 6APV 3L4 2.73973
14 6FNU FAD 3.42466
15 2MAS PIR 3.42466
16 1HGX 5GP 3.42466
17 2FXV 5GP 3.42466
18 1HDR NAD 3.42466
19 4L9Z COA 3.42466
20 4CNG SAH 3.42466
21 4JAW NGT GAL 3.42466
22 4N02 FNR 4.10959
23 3BZ3 YAM 4.10959
24 5EIB GTP 4.10959
25 2EV9 SKM 4.10959
26 2EV9 NAP 4.10959
27 1RX0 FAD 4.10959
28 3KRL KRL 4.10959
29 4WNP 3RJ 4.10959
30 1ICP FMN 4.10959
31 4HKP TKW 4.10959
32 5C5H 4YB 4.10959
33 2AAZ UMP 4.10959
34 4P86 5GP 4.10959
35 4H6Q TFB 4.10959
36 3NRR D16 4.10959
37 3NRR UMP 4.10959
38 4H6Q FAD 4.10959
39 3E5A VX6 4.54545
40 4I4Z 2NE 4.79452
41 5ODT ADP 4.79452
42 4YZC STU 4.79452
43 5CKW ANP 4.79452
44 4EJN 0R4 4.79452
45 2YIC TPP 5.47945
46 3AAQ ARU 5.47945
47 1QM5 GLC GLC GLC PO4 SGC GLC 5.47945
48 1QM5 PLP 5.47945
49 4LO2 GAL BGC 5.47945
50 1CJW COT 5.47945
51 1LBF 137 5.47945
52 1HV9 COA 5.47945
53 4X7Q 3YR 5.47945
54 2Q3O FMN 6.16438
55 5D2R 56W 6.16438
56 2GJ5 VD3 6.16438
57 4O67 1SY 6.16438
58 4TMC HBA 6.84932
59 4OUJ LBT 6.84932
60 4EHU ANP 6.84932
61 4OTH DRN 6.84932
62 1F28 UMP 6.84932
63 5JBE GLC GLC GLC GLC GLC 6.84932
64 4EIL UMP 6.84932
65 3AI7 TPP 6.84932
66 1QMG APX 6.84932
67 3MKN DNB 7.53425
68 4IJP 1EH 7.53425
69 4GJ3 0XP 7.53425
70 4UMJ BFQ 7.53425
71 5LXM ADP 7.89474
72 5G1X ADP 7.93651
73 5L8L ADP 8.21918
74 4FFG 0U8 8.21918
75 2PWY SAH 8.21918
76 2X2M X2M 8.90411
77 1D01 ACE MET LEU SER VAL GLU GLU GLU GLY 8.90411
78 1VYP TNF 8.90411
79 1RC0 KT5 9.58904
80 1J3I UMP 9.58904
81 1OLT SAM 10.274
82 1QSC ACE TYR PRO ILE GLN GLU THR 10.9589
83 5NC1 NAG 12.3288
84 1OYB HBA 14.3836
85 5EYK 5U5 16.9492
86 3B2Q ATP 17.1233
87 4C2V YJA 18.1818
88 4C2W ANP 19.2308
89 2HY0 306 19.863
Pocket No.: 3; Query (leader) PDB : 3P7G; Ligand: MAN; Similar sites found with APoc: 52
This union binding pocket(no: 3) in the query (biounit: 3p7g.bio1) has 9 residues
No: Leader PDB Ligand Sequence Similarity
1 3GFS FMN None
2 5HGZ ACO 2.05479
3 3AR5 TM1 2.73973
4 1YKF NAP 2.73973
5 2VH6 GSV 2.73973
6 3LM9 ADP 2.73973
7 3VBK COA 3.42466
8 2X3J ATP 3.42466
9 2X3J X3J 3.42466
10 1NFU RRP 3.42466
11 3VBK 0FX 3.42466
12 1LC3 NAD 3.42466
13 1PQ7 ARG 3.42466
14 2OQ5 BEN 3.42466
15 5WB6 9ZM 3.42466
16 5Q0F 9FA 3.42466
17 4JAW GAL NGT 3.42466
18 1QL9 ZEN 4.10959
19 2A5F NAD 4.10959
20 2P3T 993 4.10959
21 2BDG PBZ 4.10959
22 1RTF BEN 4.79452
23 4OM8 NAD 4.79452
24 3NJ4 NAD 4.79452
25 1DQN IMU 4.79452
26 4MIG G3F 4.79452
27 4EDK GTP 4.79452
28 5YAK FMN 4.79452
29 3RET SAL 4.9505
30 1O5E 132 5.26316
31 2ANM CDO 5.47945
32 2ANK N12 5.47945
33 1TMT DPN PRO ARG 5.47945
34 1EB1 ZAL PRO MMO 5.47945
35 2A2X NA9 5.47945
36 1D9I 00P 5.47945
37 5U97 PIT 5.47945
38 6AIX A3P 6.16438
39 4O97 NTX 6.16438
40 4AK7 47N 6.16438
41 2YFT DQR 6.16438
42 5HPZ 68G 6.84932
43 2C29 NAP 6.84932
44 2PKA BEN 7.5
45 4YDD MGD 8.90411
46 4YDD MD1 8.90411
47 1Y60 H4M 10.274
48 1RLJ FMN 10.7914
49 5O98 NAP 12.3288
50 4MTI 2DX 13.0137
51 3W6G FLC 13.6986
52 1FIW PBZ 31.8182
Pocket No.: 4; Query (leader) PDB : 3P7G; Ligand: MAN; Similar sites found with APoc: 12
This union binding pocket(no: 4) in the query (biounit: 3p7g.bio3) has 10 residues
No: Leader PDB Ligand Sequence Similarity
1 5D9J 0N8 None
2 5VXC COA None
3 1GJC 130 2.05479
4 3GD4 FAD 3.42466
5 1NLU IVA PHI TYB 4.10959
6 5O0J 8BR 4.79452
7 1EWY FAD 4.79452
8 3H4L ANP 6.16438
9 5UAO FAD 7.53425
10 2CER PGI 10.274
11 4W8B GLC BGC BGC XYS BGC XYS XYS GAL 11.6438
12 3VZS NAP 12.3288
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