Receptor
PDB id Resolution Class Description Source Keywords
3OQ5 2.5 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF THE 3-MBT DOMAIN FROM HUMAN L3MBTL1 IN WITH P53K382ME1 HOMO SAPIENS L(3)MBT-LIKE PROTEIN PROTEIN LYSINE METHYLTRANSFERASE; MALIBRAIN TUMOR CHROMATIN REGULATOR DNA-BINDING METAL-BINDINNUCLEUS REPRESSOR TRANSCRIPTION REGULATION ZINC-FINGER CHROMOSOMAL PROTEIN METHYLATION THREE-LEAVED BETA-PROPELLTRANSCRIPTION P53
Ref.: THE MBT REPEATS OF L3MBTL1 LINK SET8-MEDIATED P53 METHYLATION AT LYSINE 382 TO TARGET GENE REPRESSION J.BIOL.CHEM. V. 285 37725 2010
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
THR SER ARG HIS LYS MLZ LEU MET PHE LYS D:382;
E:382;
 Valid;
Valid;
 none;
none;
 submit data
146.234 n/a O=CC(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2RHI 1.66 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF THE 3-MBT DOMAIN FROM HUMAN L3MBTL1 IN COMPLEX WITH H1.5K27ME2 AT 1.66 ANGSTROM HOMO SAPIENS BETA BARREL PROTEIN-PEPTIDE COMPLEX DIMETHYL-LYSINE ALTERNATIVE SPLICING CHROMATIN REGULATOR DNA-BINDING METAL-BINDING NUCLEUS REPRESSOR TRANSCRIPTION TRANSCRIPTION REGULATION ZINC ZINC-FINGER TRANSCRIPTION/NUCLEAR PROTEIN COMPLEX
Ref.: STRUCTURAL BASIS FOR LOWER LYSINE METHYLATION STATE-SPECIFIC READOUT BY MBT REPEATS OF L3MBTL1 AND AN ENGINEERED PHD FINGER. MOL.CELL V. 28 677 2007
Members (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 2RHX - MLY C8 H18 N2 O2 CN(C)CCCC[....
2 2RHU - MLY C8 H18 N2 O2 CN(C)CCCC[....
3 3OQ5 - THR SER ARG HIS LYS MLZ LEU MET PHE LYS n/a n/a
4 2PQW - ARG HIS ARG MLY VAL LEU ARG ASP ASN n/a n/a
5 2RHY - MLZ C7 H16 N2 O2 CNCCCC[C@@....
6 2RHI - LYS ALA THR LYS MLY n/a n/a
70% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 2RHX - MLY C8 H18 N2 O2 CN(C)CCCC[....
2 2RHU - MLY C8 H18 N2 O2 CN(C)CCCC[....
3 3OQ5 - THR SER ARG HIS LYS MLZ LEU MET PHE LYS n/a n/a
4 2PQW - ARG HIS ARG MLY VAL LEU ARG ASP ASN n/a n/a
5 2RHY - MLZ C7 H16 N2 O2 CNCCCC[C@@....
6 2RHI - LYS ALA THR LYS MLY n/a n/a
50% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 2RHX - MLY C8 H18 N2 O2 CN(C)CCCC[....
2 2RHU - MLY C8 H18 N2 O2 CN(C)CCCC[....
3 3OQ5 - THR SER ARG HIS LYS MLZ LEU MET PHE LYS n/a n/a
4 2PQW - ARG HIS ARG MLY VAL LEU ARG ASP ASN n/a n/a
5 2RHY - MLZ C7 H16 N2 O2 CNCCCC[C@@....
6 2RHI - LYS ALA THR LYS MLY n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: THR SER ARG HIS LYS MLZ LEU MET PHE LYS; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 THR SER ARG HIS LYS MLZ LEU MET PHE LYS 1 1
2 SER SER HIS LEU MLY SER LYS LYS GLY GLN 0.459459 0.852941
3 LYS ALA ALA ARG ALY SER ALA PRO ALA 0.404762 0.735294
Similar Ligands (3D)
Ligand no: 1; Ligand: THR SER ARG HIS LYS MLZ LEU MET PHE LYS; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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