Receptor
PDB id Resolution Class Description Source Keywords
3MX2 1.98 Å NON-ENZYME: OTHER LASSA FEVER VIRUS NUCLEOPROTEIN COMPLEXED WITH DTTP LASSA VIRUS NUCLEOPROTEIN LASSA FEVER VIRUS STRUCTURAL GENOMICS SCOTTSTRUCTURAL PROTEOMICS FACILITY SSPF NUCLEAR PROTEIN
Ref.: CAP BINDING AND IMMUNE EVASION REVEALED BY LASSA NUCLEOPROTEIN STRUCTURE. NATURE V. 468 779 2010
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
TTP A:800;
B:800;
C:800;
Valid;
Valid;
Valid;
none;
none;
none;
submit data
482.168 C10 H17 N2 O14 P3 CC1=C...
ZN A:570;
B:570;
C:570;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3MX2 1.98 Å NON-ENZYME: OTHER LASSA FEVER VIRUS NUCLEOPROTEIN COMPLEXED WITH DTTP LASSA VIRUS NUCLEOPROTEIN LASSA FEVER VIRUS STRUCTURAL GENOMICS SCOTTSTRUCTURAL PROTEOMICS FACILITY SSPF NUCLEAR PROTEIN
Ref.: CAP BINDING AND IMMUNE EVASION REVEALED BY LASSA NUCLEOPROTEIN STRUCTURE. NATURE V. 468 779 2010
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 3MX2 - TTP C10 H17 N2 O14 P3 CC1=CN(C(=....
2 3MX5 - UTP C9 H15 N2 O15 P3 C1=CN(C(=O....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 3MX2 - TTP C10 H17 N2 O14 P3 CC1=CN(C(=....
2 3MX5 - UTP C9 H15 N2 O15 P3 C1=CN(C(=O....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 3MX2 - TTP C10 H17 N2 O14 P3 CC1=CN(C(=....
2 3MX5 - UTP C9 H15 N2 O15 P3 C1=CN(C(=O....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: TTP; Similar ligands found: 84
No: Ligand ECFP6 Tc MDL keys Tc
1 TTP 1 1
2 TYD 0.884058 1
3 TMP 0.760563 0.985714
4 TLO 0.722892 0.945205
5 DAU 0.701149 0.932432
6 TRH 0.689655 0.932432
7 1JB 0.689655 0.932432
8 TDX 0.689655 0.945205
9 3R2 0.689655 0.92
10 18T 0.689655 0.932432
11 T3Q 0.674157 0.907895
12 3YN 0.674157 0.932432
13 DWN 0.674157 0.907895
14 T3F 0.674157 0.907895
15 0N2 0.666667 0.896104
16 T46 0.666667 0.932432
17 0FX 0.659341 0.907895
18 MMF 0.659341 0.907895
19 TTP MG 0.646341 0.943662
20 QDM 0.645161 0.896104
21 FNF 0.638298 0.92
22 JHZ 0.638298 0.884615
23 1YF 0.638298 0.92
24 AKM 0.638298 0.886076
25 9RC 0.636364 0.829268
26 4TG 0.631579 0.92
27 DUT 0.62963 0.957143
28 TBD 0.62963 0.958904
29 D3T 0.62963 0.971831
30 T5A 0.61165 0.841463
31 LLT 0.605634 0.873239
32 THM 0.605634 0.873239
33 ATY 0.6 0.945205
34 FUH 0.588235 0.907895
35 QUH 0.588235 0.907895
36 AZD 0.586207 0.907895
37 UFP 0.56962 0.905405
38 0DN 0.567568 0.833333
39 DCP 0.55814 0.891892
40 BRU 0.54321 0.905405
41 5HU 0.54321 0.971831
42 DUD 0.542169 0.957143
43 NYM 0.536585 0.958333
44 FDM 0.536585 0.918919
45 5IU 0.536585 0.905405
46 F6G 0.534091 0.855263
47 ABT 0.531915 0.884615
48 T3P 0.531646 0.943662
49 THP 0.53012 0.971429
50 D4T 0.528736 0.928571
51 6U4 0.521277 0.848101
52 ATM 0.517241 0.894737
53 TQP 0.512605 0.864198
54 7SG 0.512605 0.864198
55 TXS 0.512195 0.789474
56 TPE 0.510204 0.894737
57 T4K 0.508333 0.853659
58 T5K 0.508333 0.853659
59 3DR DT DT DT DT DT 0.504854 0.905405
60 BVP 0.5 0.944444
61 T3S 0.5 0.789474
62 8DG 0.489583 0.829268
63 BUP 0.477778 0.842105
64 YYY 0.477273 0.891892
65 2DT 0.47561 0.957747
66 4TA 0.469565 0.807229
67 DT ME6 DT 0.468468 0.87013
68 D4D 0.449438 0.928571
69 DU 0.447059 0.942857
70 UMP 0.447059 0.942857
71 AZZ 0.447059 0.779221
72 523 0.442105 0.921053
73 5CM 0.438202 0.918919
74 DUP 0.430108 0.930556
75 ADS THS THS THS 0.429752 0.758621
76 UTP 0.428571 0.875
77 8DD 0.424242 0.8125
78 U5F 0.423913 0.875
79 WMJ 0.42 0.761905
80 DDN 0.418605 0.942857
81 8GD 0.418367 0.829268
82 DGT 0.415842 0.759036
83 UC5 0.406593 0.943662
84 ID2 0.402439 0.8
Similar Ligands (3D)
Ligand no: 1; Ligand: TTP; Similar ligands found: 28
No: Ligand Similarity coefficient
1 DTP 0.9873
2 DZ4 0.9766
3 MG TTP 0.9753
4 HF7 0.9630
5 HEJ 0.9540
6 HDV 0.9485
7 HF4 0.9432
8 DUT MG 0.9338
9 HFD 0.9332
10 JSQ 0.9100
11 GTF 0.9093
12 ACP 0.9066
13 ANP 0.9060
14 CTP 0.8971
15 AGS 0.8934
16 ATP 0.8917
17 3AT 0.8877
18 GTP 0.8866
19 2KH 0.8825
20 0RC 0.8807
21 DCT 0.8752
22 APC 0.8740
23 MGT 0.8701
24 SAM 0.8585
25 UDP 0.8581
26 ADP BEF 0.8567
27 GNP 0.8526
28 ADP ALF 0.8523
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3MX2; Ligand: TTP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 3mx2.bio4) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 3MX2; Ligand: TTP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 3mx2.bio1) has 20 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 3MX2; Ligand: TTP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 3mx2.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 3MX2; Ligand: TTP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 3mx2.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 3MX2; Ligand: TTP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 3mx2.bio2) has 20 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 3MX2; Ligand: TTP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 3mx2.bio3) has 19 residues
No: Leader PDB Ligand Sequence Similarity
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